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Establishing a new paradigm of pathogenesis of the diseases through the understanding of stem cell aging

International Activities Supporting Group

Project AreaEstablishing a new paradigm of the pathogenesis of diseases through the understanding of stem cell aging
Project/Area Number 15K21751
Research Category

Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)

Allocation TypeMulti-year Fund
Review Section Biological Sciences
Research InstitutionThe University of Tokyo (2018)
Chiba University (2015-2017)

Principal Investigator

Iwama Atsushi  東京大学, 医科学研究所, 教授 (70244126)

Co-Investigator(Kenkyū-buntansha) 田久保 圭誉  国立研究開発法人国立国際医療研究センター, その他部局等, 生体恒常性プロジェクト長 (50502788)
波江野 洋  国立研究開発法人国立がん研究センター, 先端医療開発センター, 特任研究員 (70706754)
Research Collaborator Nishimura Emi  
Sato Toshiro  
Minamino Toru  
Nabeshima Yoichi  
Sanada Masashi  
Project Period (FY) 2015-11-06 – 2019-03-31
Project Status Completed (Fiscal Year 2018)
Budget Amount *help
¥52,910,000 (Direct Cost: ¥40,700,000、Indirect Cost: ¥12,210,000)
Fiscal Year 2018: ¥14,430,000 (Direct Cost: ¥11,100,000、Indirect Cost: ¥3,330,000)
Fiscal Year 2017: ¥14,430,000 (Direct Cost: ¥11,100,000、Indirect Cost: ¥3,330,000)
Fiscal Year 2016: ¥14,430,000 (Direct Cost: ¥11,100,000、Indirect Cost: ¥3,330,000)
Fiscal Year 2015: ¥9,620,000 (Direct Cost: ¥7,400,000、Indirect Cost: ¥2,220,000)
Keywordsステムセルエイジング / 幹細胞 / 老化 / 疾患 / エイジング
Outline of Final Research Achievements

We initiated and promoted exchanges with EU aging research project "SyStemAge", Lund Stem Cell Center,University of Singapore, French National Science Research Center, and European Research Institute for the Biology of Ageing. We supported young PIs and post-doctors to perform collaborative research projects at Harvard University, Lund Stem Cell Center, Duke University, Colombia University, and Max-Plank Institute for a long term, and also encouraged short visits to their collaboration partners. We also invited young researchers from University of Singapore, French National Science Research Center,and Stanford University to do collaborative studies.

Academic Significance and Societal Importance of the Research Achievements

本学術領域研究は、我が国において老化や幹細胞、疾患研究などの領域において個別に行われていたエイジング研究を統合し、老化を「組織幹細胞の加齢に伴う変化(ステムセルエイジング)」の観点から観察し、加齢に伴う組織・臓器機能の劣化や疾患を体系的に理解するために新たに立ち上げたものであった。このような中、本国際活動支援により、多くの国際連携機関と情報交換・共同研究を行うことが可能となり、様々な海外の動向を見極めながら、高いレベルのサイエンスを実践することができたものと考えている。また、多くの若手研究者を海外の研究機関に派遣し、次世代の研究を担う人材の育成にも成果を得ることができたことも重要な点である。

Report

(5 results)
  • 2018 Annual Research Report   Final Research Report ( PDF )
  • 2017 Research-status Report
  • 2016 Research-status Report
  • 2015 Research-status Report
  • Research Products

    (35 results)

All 2019 2018 2017 Other

All Int'l Joint Research (19 results) Journal Article (8 results) (of which Int'l Joint Research: 7 results,  Peer Reviewed: 7 results,  Open Access: 3 results) Presentation (5 results) (of which Int'l Joint Research: 4 results,  Invited: 5 results) Remarks (3 results)

  • [Int'l Joint Research] ルンド大学(スウェーデン)

    • Related Report
      2018 Annual Research Report
  • [Int'l Joint Research] メルボルン大学(オーストラリア)

    • Related Report
      2018 Annual Research Report
  • [Int'l Joint Research] Baylor大学(米国)

    • Related Report
      2018 Annual Research Report
  • [Int'l Joint Research] シンガポール大学(シンガポール)

    • Related Report
      2018 Annual Research Report
  • [Int'l Joint Research] ハイデルベルグ大学(ドイツ)

    • Related Report
      2018 Annual Research Report
  • [Int'l Joint Research] スタンフォード大学/コーネル大学/コロンビア大学(米国)

    • Related Report
      2017 Research-status Report
  • [Int'l Joint Research] シンガポール大学(シンガポール)

    • Related Report
      2017 Research-status Report
  • [Int'l Joint Research] ルンド大学(スウェーデン)

    • Related Report
      2017 Research-status Report
  • [Int'l Joint Research] ハイデルベルグ大学(ドイツ)

    • Related Report
      2017 Research-status Report
  • [Int'l Joint Research] フローニンゲン大学(オランダ)

    • Related Report
      2017 Research-status Report
  • [Int'l Joint Research] Cornell University/Stanford University(米国)

    • Related Report
      2016 Research-status Report
  • [Int'l Joint Research] Singapore University(Singapore)

    • Related Report
      2016 Research-status Report
  • [Int'l Joint Research] Lund University(Sweden)

    • Related Report
      2016 Research-status Report
  • [Int'l Joint Research] Heidelberg University(Germany)

    • Related Report
      2016 Research-status Report
  • [Int'l Joint Research] Froningen University(オランダ)

    • Related Report
      2016 Research-status Report
  • [Int'l Joint Research] ハイデルベルク大学/Max Plank研究所(ドイツ)

    • Related Report
      2015 Research-status Report
  • [Int'l Joint Research] がん研究所(シンガポール)

    • Related Report
      2015 Research-status Report
  • [Int'l Joint Research] ルンド大学(スウェーデン)

    • Related Report
      2015 Research-status Report
  • [Int'l Joint Research] ハーバード大学/スタンフォード大学(米国)

    • Related Report
      2015 Research-status Report
  • [Journal Article] Divergent Routes toward Wnt and R-spondin Niche Independency during Human Gastric Carcinogenesis2018

    • Author(s)
      Nanki Kosaku、Toshimitsu Kohta、Takano Ai、Fujii Masayuki、Takahashi Sirirat、Sukawa Yasutaka、Ishida Hiroki、Sugimoto Shinya、Kawakubo Hirofumi、Kim Jihoon、Kitagawa Yuko、Sekine Shigeki、Koo Bon-Kyoung、Kanai Takanori、Sato Toshiro
    • Journal Title

      Cell

      Volume: 174 Issue: 4 Pages: 856-869

    • DOI

      10.1016/j.cell.2018.07.027

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Bcor insufficiency promotes initiation and progression of myelodysplastic syndrome.2018

    • Author(s)
      Tara S, Isshiki Y, Nakajima-Takagi Y, Oshima M, Aoyama K, Tanaka T, Shinoda D, Koide S, Saraya A, Miyagi S, Manabe I, Matsui H, Koseki H, Bardwell VJ, Iwama A.
    • Journal Title

      Blood

      Volume: 132(23) Issue: 23 Pages: 2470-2483

    • DOI

      10.1182/blood-2018-01-827964

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Human Pancreatic Tumor Organoids Reveal Loss of Stem Cell Niche Factor Dependence during Disease Progression.2018

    • Author(s)
      Seino T, Kawasaki S, Shimokawa M, Tamagawa H, Toshimitsu K, Fujii M, Ohta Y, Matano M, Nanki K, Kawasaki K, Takahashi S, Sugimoto S, Iwasaki E, Takagi J, Itoi T, Kitago M, Kitagawa Y, Kanai T, Sato T.
    • Journal Title

      Cell Stem Cell.

      Volume: 22 Issue: 3 Pages: 454-467

    • DOI

      10.1016/j.stem.2017.12.009

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Spred1 Safeguards Hematopoietic Homeostasis against Diet-Induced Systemic Stress2018

    • Author(s)
      Tadokoro Yuko、Hoshii Takayuki、Yamazaki Satoshi、Eto Koji、Ema Hideo、Kobayashi Masahiko、Ueno Masaya、Ohta Kumiko、Arai Yuriko、Hara Eiji、Harada Kenichi、Oshima Masanobu、Oshima Hiroko、Arai Fumio、Yoshimura Akihiko、Nakauchi Hiromitsu、Hirao Atsushi
    • Journal Title

      Cell Stem Cell

      Volume: 22 Issue: 5 Pages: 713-725

    • DOI

      10.1016/j.stem.2018.04.002

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Expression of mutant Asxl1 perturbs hematopoiesis and promotes susceptibility to leukemic transformation2018

    • Author(s)
      Nagase R, Inoue D, Pastore A, Fujino T, Hou HA, Yamasaki N, Goyama S, Saika M, Kanai A, Sera Y, Horikawa S, Ota Y, Asada S, Hayashi Y, Kawabata KC, Takeda R, Tien HF, Honda H, Abdel-Wahab O, Kitamura T.
    • Journal Title

      The Journal of Experimental Medicine

      Volume: 印刷中 Issue: 6 Pages: 1729-1747

    • DOI

      10.1084/jem.20171151

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Pathogen-Induced TLR4-TRIF Innate Immune Signaling in Hematopoietic Stem Cells Promotes Proliferation but Reduces Competitive Fitness.2017

    • Author(s)
      Takizawa H, Fritsch K, Kovtonyuk LV, Saito Y, Yakkala C, Jacobs K, Ahuja AK, Lopes M, Hausmann A, Hardt WD, Gomariz A, Nombela-Arrieta C, Manz MG.
    • Journal Title

      Cell Stem Cell

      Volume: 21 Issue: 2 Pages: 225-240

    • DOI

      10.1016/j.stem.2017.06.013

    • Related Report
      2017 Research-status Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Dual inhibition of EZH2 and EZH1 sensitizes PRC2-dependent tumors to proteasome inhibition.2017

    • Author(s)
      Ola Rizq, Naoya Mimura, Motohiko Oshima, Atsunori Saraya, Shuhei Koide, Yuko Kato, Kazumasa Aoyama, Yaeko Nakajima-Takagi, Changshan Wang, Tetsuhiro Chiba, Anqi Ma, Jian Jin, Tohru Iseki, Chiaki Nakaseko, and Atsushi Iwama
    • Journal Title

      Clinical Cancer Research

      Volume: 23(16) Issue: 16 Pages: 4817-4830

    • DOI

      10.1158/1078-0432.ccr-16-2735

    • Related Report
      2017 Research-status Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Targeted BMI1 inhibition impairs tumor growth in lung adenocarcinomas with low CEBPα expression.2017

    • Author(s)
      Yong KJ, et al., Iwama A, Lim B, Halmos B, Neuberg D, Tenen DG, Levantini E.
    • Journal Title

      Sci Transl Med

      Volume: 8 Issue: 350

    • DOI

      10.1126/scitranslmed.aad6066

    • Related Report
      2017 Research-status Report
  • [Presentation] UTX insufficiency in the pathogenesis of multiple myeloma2019

    • Author(s)
      Atsushi Iwama
    • Organizer
      2019 US-Japan Symposium on Normal/Malignant Hematopoiesis and Novel Therapies for Hematologic Malignancies
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] PRC1.1, a variant polycomb repressive complex 1 in normal and malignant hematopoiesis2019

    • Author(s)
      Atsushi Iwama
    • Organizer
      9th Biennial Workshop on the Clinical Translation of Epigenetics in Cancer Therapy
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] 造血幹細胞の加齢変化を規定するエピゲノム特性2018

    • Author(s)
      岩間厚志
    • Organizer
      第65回日本実験動物学会総会
    • Related Report
      2018 Annual Research Report
    • Invited
  • [Presentation] 造血幹細胞のエイジングと加齢関連腫瘍2018

    • Author(s)
      岩間厚志
    • Organizer
      帝京大学アジア国際感染制御研究所創設5周年記念国際シンポジウム
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] PRC1.1, a variant polycomb repressive complex 1 in normal and malignant hematopoiesis2018

    • Author(s)
      Atsushi Iwama
    • Organizer
      McCulloch & Till Lecture Award, The 47th Annual Scientific Meeting, International Society for Experimental Hematology
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research / Invited
  • [Remarks] ステムセルエイジング領域HP

    • URL

      http://www.ims.u-tokyo.ac.jp/molmed/stemcellaging/index.html

    • Related Report
      2018 Annual Research Report
  • [Remarks] 新学術領域「ステムセルエイジングと疾患」国際活動支援班

    • URL

      http://www.m.chiba-u.ac.jp/class/molmed/stemcellaging/international/index.html

    • Related Report
      2017 Research-status Report 2016 Research-status Report
  • [Remarks] ステムセルエイジングから解明する疾患原理

    • URL

      http://www.m.chiba-u.ac.jp/class/molmed/stemcellaging/results/index.html

    • Related Report
      2015 Research-status Report

URL: 

Published: 2015-11-10   Modified: 2023-03-16  

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