Establishment of international research community on cell death

• Project Area: Homeostatic Regulation by Various Types of Cell Death
• Project/Area Number: 15K21753
• Research Category: Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)
• Allocation Type: Multi-year Fund
• Review Section: Biological Sciences
• Research Institution: Tokyo University of Pharmacy and Life Science
• Principal Investigator: Tanaka Masato 東京薬科大学, 生命科学部, 教授 (00294059)
• Co-Investigator(Kenkyū-buntansha): 中野 裕康 東邦大学, 医学部, 教授 (70276476) ; 田中 稔 国立研究開発法人国立国際医療研究センター, その他部局等, 細胞療法開発研究室長 (80321909) ; 須田 貴司 金沢大学, がん進展制御研究所, 教授 (70250090) ; 安友 康二 徳島大学, 大学院医歯薬学研究部(医学域), 教授 (30333511) ; 山崎 晶 大阪大学, 微生物病研究所, 教授 (40312946) ; 山口 良文 北海道大学, 低温科学研究所, 教授 (10447443) ; 袖岡 幹子 国立研究開発法人理化学研究所, 開拓研究本部, 主任研究員 (60192142)
• Project Period (FY): 2015-11-06 – 2019-03-31
• Project Status: Completed (Fiscal Year 2018)
• Budget Amount: ¥52,780,000 (Direct Cost: ¥40,600,000、Indirect Cost: ¥12,180,000); Fiscal Year 2018: ¥13,650,000 (Direct Cost: ¥10,500,000、Indirect Cost: ¥3,150,000); Fiscal Year 2017: ¥13,650,000 (Direct Cost: ¥10,500,000、Indirect Cost: ¥3,150,000); Fiscal Year 2016: ¥13,650,000 (Direct Cost: ¥10,500,000、Indirect Cost: ¥3,150,000); Fiscal Year 2015: ¥11,830,000 (Direct Cost: ¥9,100,000、Indirect Cost: ¥2,730,000)
• Keywords: 細胞死 / 免疫 / 炎症 / 再生

Outline of Final Research Achievements

This project aimed to establish the international research community on cell death. For this purpose, we performed following activities. 1. we held a closed meeting with Australian cell death researchers in Tokyo. We also held a closed international meeting for young investigators simultaneously. 2. We supported international personnel exchange to promote collaborative research. 3. We supported international collaborative research and published 8 papers in international scientific journals.

Academic Significance and Societal Importance of the Research Achievements

日豪国際細胞死共同研究協議会ならびに若手協議会の開催、人的交流を行うことで、オーストラリアを中心とした細胞死関連研究者グループとの緊密な国際連携体制を構築することができた。この国際連携体制を基に、オーストラリア以外の国々へのネットワーク拡大と持続的な国際共同研究の足がかりを築くことができた。また、国際学会等で主導的な立場で活躍できる研究者や、将来の日本の細胞死研究を担う若手研究者の育成を行うことができた。

Research Products

• [Int'l Joint Research] WEHI/University of Melbourne(オーストラリア)
• [Int'l Joint Research] Michigan University/Harvard University(米国)
• [Int'l Joint Research] Hanover University/University of Cologne(ドイツ)
• [Int'l Joint Research] Tronto University(カナダ)
• [Int'l Joint Research] Shandong University(中国)
• [Int'l Joint Research]
• [Int'l Joint Research] WEHI(オーストラリア)
• [Int'l Joint Research] Michigan University/Mayo clinic college of medicine(米国)
• [Int'l Joint Research] Victoria University(ニュージーランド)
• [Int'l Joint Research] INSERM(フランス)
• [Int'l Joint Research] University Bonn/University Cologne(ドイツ)
• [Int'l Joint Research]
• [Int'l Joint Research] WEHI/Melbourne University/Victoria University(オーストラリア)
• [Int'l Joint Research] Michigan University(米国)
• [Int'l Joint Research] Victoria University(ニュージーランド)
• [Int'l Joint Research] INSERM/Institut Curie(フランス)
• [Int'l Joint Research] Aberdeen University(英国)
• [Int'l Joint Research] The Walter and Eliza Hall Institute/メルボルン大学/La Trobe University(オーストラリア)
• [Int'l Joint Research] ビクトリア大学(ニュージーランド)
• [Journal Article] Mycobacterium tuberculosis β-gentiobiosyl diacylglycerides signal through the pattern recognition receptor Mincle: total synthesis and structure activity relationships. (2015)
  • Author(s): Richardson MB, Torigoe S, Yamasaki S, Williams SJ.
  • Journal Title: Chemical Communications Volume: 51 Issue: 81 Pages: 15027-15030
  • DOI: 10.1039/c5cc04773k
  • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
• [Funded Workshop] 日豪国際細胞死共同研究協議会 (2018)
• [Funded Workshop] 日豪国際細胞死共同研究若手協議会 (2018)