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International netoworking on cell competition for the next generation

International Activities Supporting Group

Project AreaCell competition: a mechanism for survival of the fittest in the multi-cellular community
Project/Area Number 15K21757
Research Category

Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)

Allocation TypeMulti-year Fund
Review Section Biological Sciences
Research InstitutionHokkaido University

Principal Investigator

Fujita Yasuyuki  北海道大学, 遺伝子病制御研究所, 教授 (50580974)

Co-Investigator(Kenkyū-buntansha) 井垣 達吏  京都大学, 生命科学研究科, 教授 (00467648)
倉永 英里奈  東北大学, 生命科学研究科, 教授 (90376591)
鈴木 聡  神戸大学, 医学研究科, 教授 (10311565)
一條 秀憲  東京大学, 大学院薬学系研究科(薬学部), 教授 (00242206)
石谷 太  群馬大学, 生体調節研究所, 教授 (40448428)
Research Collaborator Tada Masazumi  
Levayer Romain  Institut Pasteur
Dahmann Christian  ドレスデン工科大学
Toyama Yusuke  National University of Singapore
Hyman Anthony  Max Plank Institute
Yan Yan  香港科技大学
Bach Erika  ニューヨーク大学
Vittelo Elisa  グルノーブル大学
Elleni Bali  EPFL
Project Period (FY) 2015-11-06 – 2019-03-31
Project Status Completed (Fiscal Year 2018)
Budget Amount *help
¥65,520,000 (Direct Cost: ¥50,400,000、Indirect Cost: ¥15,120,000)
Fiscal Year 2018: ¥16,380,000 (Direct Cost: ¥12,600,000、Indirect Cost: ¥3,780,000)
Fiscal Year 2017: ¥16,380,000 (Direct Cost: ¥12,600,000、Indirect Cost: ¥3,780,000)
Fiscal Year 2016: ¥16,380,000 (Direct Cost: ¥12,600,000、Indirect Cost: ¥3,780,000)
Fiscal Year 2015: ¥16,380,000 (Direct Cost: ¥12,600,000、Indirect Cost: ¥3,780,000)
Keywords細胞競合
Outline of Final Research Achievements

We organized 2nd (Madrid) and 3rd (Sapporo) Cell Competition International Symposium, and UK-Japan symposium on cell competition (London) to present our research achievement to foreign scientists and to provoke international collaboration with the attendees. In addition, to facilitate international collaborations on cell competition, a number of young Japanese scientists have sent to several research institutes in forein countries. Moreover, several outstanding cell competition experts or young scientists have been invited to come over to Japan.

Academic Significance and Societal Importance of the Research Achievements

細胞競合現象の重要性が明らかになりつつある今、世界初の細胞競合の融合研究体制を構築し、これを組織的・戦略的に推進することで、この新たな研究領域で世界をリードできる絶好の時期にきている。現在、世界的にも発展途上である細胞競合研究をさらに持続的に強く推進し、我が国の細胞競合研究の国際競争力を強化していくには以下の課題を解決する必要があり、国際共同研究加速基金によってそれらに非常にポジティブな効果をもたらすことが大いに期待できた。

Report

(5 results)
  • 2018 Annual Research Report   Final Research Report ( PDF )
  • 2017 Research-status Report
  • 2016 Research-status Report
  • 2015 Research-status Report
  • Research Products

    (61 results)

All 2018 2017 2016 2015 Other

All Int'l Joint Research (17 results) Journal Article (18 results) (of which Int'l Joint Research: 11 results,  Peer Reviewed: 18 results,  Open Access: 18 results,  Acknowledgement Compliant: 3 results) Presentation (23 results) (of which Int'l Joint Research: 18 results,  Invited: 23 results) Remarks (2 results) Patent(Industrial Property Rights) (1 results)

  • [Int'l Joint Research] Oxford University/London Centre for Nanotechnology/University College London(英国)

    • Related Report
      2018 Annual Research Report
  • [Int'l Joint Research] 香港科技大学(中国)

    • Related Report
      2018 Annual Research Report
  • [Int'l Joint Research] IMBA(オーストリア)

    • Related Report
      2018 Annual Research Report
  • [Int'l Joint Research] トロント大学(カナダ)

    • Related Report
      2018 Annual Research Report
  • [Int'l Joint Research] ドレスデン工科大学/Max Planck Institute(ドイツ)

    • Related Report
      2018 Annual Research Report
  • [Int'l Joint Research]

    • Related Report
      2018 Annual Research Report
  • [Int'l Joint Research] University College London(英国)

    • Related Report
      2017 Research-status Report
  • [Int'l Joint Research] Swiss Institute of Technology Lausanne(スイス)

    • Related Report
      2017 Research-status Report
  • [Int'l Joint Research] University College London/Cardiff University/University of Exeter(英国)

    • Related Report
      2016 Research-status Report
  • [Int'l Joint Research] University of Bern/ETH Zurich(スイス)

    • Related Report
      2016 Research-status Report
  • [Int'l Joint Research] dkfz/Hubrecht Institute(ドイツ)

    • Related Report
      2016 Research-status Report
  • [Int'l Joint Research] University of Tronto/Cambell Family Institute(カナダ)

    • Related Report
      2016 Research-status Report
  • [Int'l Joint Research] Technical University Dresden(ドイツ)

    • Related Report
      2015 Research-status Report
  • [Int'l Joint Research] UC Davis/クリーブランドクリニック(米国)

    • Related Report
      2015 Research-status Report
  • [Int'l Joint Research] トロント大学(カナダ)

    • Related Report
      2015 Research-status Report
  • [Int'l Joint Research] University College London(英国)

    • Related Report
      2015 Research-status Report
  • [Int'l Joint Research] University of Bern(スイス)

    • Related Report
      2015 Research-status Report
  • [Journal Article] Obesity Suppresses Cell-Competition-Mediated Apical Elimination of RasV12-Transformed Cells from Epithelial Tissues2018

    • Author(s)
      Sasaki Ayana、Nagatake Takahiro、Egami Riku、Gu Guoqiang、Takigawa Ichigaku、Ikeda Wataru、Nakatani Tomoya、Kunisawa Jun、Fujita Yasuyuki
    • Journal Title

      Cell Reports

      Volume: 23 Issue: 4 Pages: 974-982

    • DOI

      10.1016/j.celrep.2018.03.104

    • NAID

      120006489805

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Mutant p53-Expressing Cells Undergo Necroptosis via Cell Competition with the Neighboring Normal Epithelial Cells2018

    • Author(s)
      Watanabe Hirotaka、Ishibashi Kojiro、Mano Hiroki、Kitamoto Sho、Sato Nanami、Hoshiba Kazuya、Kato Mugihiko、Matsuzawa Fumihiko、Takeuchi Yasuto、Shirai Takanobu、Ishikawa Susumu、Morioka Yuka、Imagawa Toshiaki、Sakaguchi Kazuyasu、Yonezawa Suguru、Kon Shunsuke、Fujita Yasuyuki
    • Journal Title

      Cell Reports

      Volume: 23 Issue: 13 Pages: 3721-3729

    • DOI

      10.1016/j.celrep.2018.05.081

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] ADAM-like Decysin-1 (ADAMDEC1) is a positive regulator of Epithelial Defense Against Cancer (EDAC) that promotes apical extrusion of RasV12-transformed cells2018

    • Author(s)
      Yako Yuta、Hayashi Takashi、Takeuchi Yasuto、Ishibashi Kojiro、Kasai Nobuhiro、Sato Nanami、Kuromiya Keisuke、Ishikawa Susumu、Fujita Yasuyuki
    • Journal Title

      Scientific Reports

      Volume: 8 Issue: 1 Pages: 9639-9639

    • DOI

      10.1038/s41598-018-27469-z

    • NAID

      120006502509

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Accumulation of the myosin-II-spectrin complex plays a positive role in apical extrusion of Src-transformed epithelial cells2018

    • Author(s)
      Mikio Takagi, Masaya Ikegawa, Takashi Shimada, Susumu Ishikawa, Mihoko Kajita, Takeshi Maruyama, Tomoko Kamasaki, Yasuyuki Fujita
    • Journal Title

      Genes to Cells

      Volume: 23 (11) Issue: 11 Pages: 974-981

    • DOI

      10.1111/gtc.12643

    • NAID

      120006734160

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] The paxillin-plectin-EPLIN complex promotes apical elimination of RasV12-transformed cells by modulating HDAC6-regulated tubulin acetylation2018

    • Author(s)
      Kasai Nobuhiro、Kadeer Ailijiang、Kajita Mihoko、Saitoh Sayaka、Ishikawa Susumu、Maruyama Takeshi、Fujita Yasuyuki
    • Journal Title

      Scientific Reports

      Volume: 8 Issue: 1 Pages: 2097-2097

    • DOI

      10.1038/s41598-018-20146-1

    • NAID

      120006456414

    • Related Report
      2017 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Cell Extrusion: A Stress-Responsive Force for Good or Evil in Epithelial Homeostasis2018

    • Author(s)
      Ohsawa Shizue、Vaughen John、Igaki Tatsushi
    • Journal Title

      Developmental Cell

      Volume: 44 Issue: 3 Pages: 284-296

    • DOI

      10.1016/j.devcel.2018.01.009

    • Related Report
      2017 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Cell competition with normal epithelial cells promotes apical extrusion of transformed cells through metabolic changes.2017

    • Author(s)
      Shunsuke Kon, et al.
    • Journal Title

      Nature Cell Biology

      Volume: 印刷中 Issue: 5 Pages: 530-541

    • DOI

      10.1038/ncb3509

    • Related Report
      2017 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Cell competition in mammals; novel homeostatic machinery for embryonic development and cancer prevention2017

    • Author(s)
      Maruyama Takeshi、Fujita Yasuyuki
    • Journal Title

      Current Opinion in Cell Biology

      Volume: 48 Pages: 106-112

    • DOI

      10.1016/j.ceb.2017.06.007

    • NAID

      120006523718

    • Related Report
      2017 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Local cellular neighborhood controls proliferation in cell competition.2017

    • Author(s)
      Bove A、Gradeci D、Fujita Y、Banerjee S、Charras G、Lowe AR
    • Journal Title

      Molecular Biology of the Cell

      Volume: 28 Pages: 3215-3228

    • Related Report
      2017 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] YAP determines the cell fate of injured mouse hepatocytes in vivo2017

    • Author(s)
      Miyamura N, Hata S, Itoh T, Tanaka M, Nishio M, Itoh M, Ogawa Y, Terai S, Sakaida I, Suzuki A, Miyajima A, Nishina H.
    • Journal Title

      Nat Commun

      Volume: 8 Issue: 1 Pages: 16017-16017

    • DOI

      10.1038/ncomms16017

    • NAID

      120006373756

    • Related Report
      2017 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Planar polarized contractile actomyosin networks in dynamic tissue morphogenesis2017

    • Author(s)
      Umetsu Daiki、Kuranaga Erina
    • Journal Title

      Current Opinion in Genetics & Development

      Volume: 45 Pages: 90-96

    • DOI

      10.1016/j.gde.2017.03.012

    • Related Report
      2017 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Plectin is a novel regulator for apical extrusion of RasV12-transformed cells.2017

    • Author(s)
      Kadeer, A., Maruyama, T., Kajita, M., Morita T., Sasaki, A., Ohoka, A., Ishikawa, S., Ikegawa, M., Shimada, T., and Fujita, Y.
    • Journal Title

      Scientific Reports

      Volume: 7 Issue: 1 Pages: 44328-44328

    • DOI

      10.1038/srep44328

    • NAID

      120006219881

    • Related Report
      2016 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] Rab5-regulated endocytosis plays a crucial role in apical extrusion of transformed cells.2017

    • Author(s)
      S. Saitoh, T. Maruyama, Y. Yako, M. Kajita, Y. Fujioka, Y. Ohba, N. Kasai, N. Sugama, S. Kon, S. Ishikawa, T. Hayashi, T. Yamazaki, M. Tada and Y. Fujita.
    • Journal Title

      Proc. Natl. Acad. Sci. U.S.A.

      Volume: 114 Issue: 12

    • DOI

      10.1073/pnas.1602349114

    • NAID

      120006346108

    • Related Report
      2016 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] MDCK cells expressing constitutively active Yes-associated protein (YAP) undergo apical extrusion depending on neighboring cell status.2016

    • Author(s)
      Chiba, T., Ishihara, E., Miyamura, N., Narumi, R., Kajita, M., Fujita, Y., Suzuki, A., Ogawa, Y. and *Nishina, H.
    • Journal Title

      Scientific Reports

      Volume: 10 Issue: 1 Pages: 28383-28383

    • DOI

      10.1038/srep28383

    • Related Report
      2016 Research-status Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] EphA2 Drives the Segregation of Ras-Transformed Epithelial Cells from Normal Neighbors.2016

    • Author(s)
      Porazinski,S., Navascues, J., Yako, Y., Hill, W., Jones, M.R., Maddison, R., Fujita, Y., and Hogan, C.
    • Journal Title

      Current Biology

      Volume: 5 Issue: 23 Pages: 3220-3229

    • DOI

      10.1016/j.cub.2016.09.037

    • Related Report
      2016 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] A role of the sphingosine-1-phosphate (S1P)- S1P receptor 2 pathway in Epithelial Defense Against Cancer (EDAC)2015

    • Author(s)
      Yamamoto, S., Yako, Y., Fujioka, Y., Kajita, M., Kameyama, T., Kon, S., Ishikawa, S., Ohba, Y., Ohno, Y., Kihara, A., and Fujita, Y.
    • Journal Title

      Molecular Biology of the Cell

      Volume: 27(3) Issue: 3 Pages: 491-499

    • DOI

      10.1091/mbc.e15-03-0161

    • NAID

      120005740332

    • Related Report
      2015 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] The cell competition-based high-throughput screening identifies small compounds that promote the elimination of RasV12-transformed cells from epithelia.2015

    • Author(s)
      Yamauchi, H., Matsumaru, T., Morita, T., Ishikawa, S., Maenaka, K., Takigawa, I., Semba, K., Kon, S. and Fujita, Y.
    • Journal Title

      Scientific Reports

      Volume: 5 Issue: 1 Pages: 15336-15336

    • DOI

      10.1038/srep15336

    • NAID

      120005674073

    • Related Report
      2015 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] EDAC: Epithelial defence against cancer- cell competition between normal and transformed epithelial cells in mammals.2015

    • Author(s)
      Kajita, M. and Fujita, Y.
    • Journal Title

      Journal of Biochemistry

      Volume: 158(1) Issue: 1 Pages: 15-23

    • DOI

      10.1093/jb/mvv050

    • NAID

      40020522502

    • Related Report
      2015 Research-status Report
    • Peer Reviewed / Open Access
  • [Presentation] Calcium wave triggers cell extrusion2018

    • Author(s)
      Yasuyuki Fujita
    • Organizer
      Gordon Research Conferences, Cell Polarity Signaling
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] 細胞間コミュニケーションの究極の理解を目指して~Cell Competition and Beyond2018

    • Author(s)
      藤田 恭之
    • Organizer
      第91回日本生化学会
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] 正常上皮細胞と変異細胞に生じる細胞競合2018

    • Author(s)
      藤田 恭之
    • Organizer
      第77回日本癌学会学術総会
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Sequential Oncogene Mutations Profoundly Influence the Outcome of Cell Competition2018

    • Author(s)
      Yasuyuki Fujita
    • Organizer
      Cell Competition in Development and Disease
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] 正常上皮細胞と変異細胞に生じる細胞競合2018

    • Author(s)
      藤田 恭之
    • Organizer
      第18回日本再生医療学会総会
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Mechanisms and roles of tumor-suppressive cell competition2018

    • Author(s)
      井垣達吏
    • Organizer
      Symposium “Cell Competition in Development and Cancer” 2018
    • Related Report
      2017 Research-status Report
    • Int'l Joint Research / Invited
  • [Presentation] 正常上皮細胞と変異細胞間に生じる細胞競合2017

    • Author(s)
      藤田 恭之
    • Organizer
      第16回日本再生医療学会総会
    • Place of Presentation
      仙台国際センター(仙台市)
    • Year and Date
      2017-03-07
    • Related Report
      2016 Research-status Report
    • Int'l Joint Research / Invited
  • [Presentation] Cell competition between normal and transformed epithelial cells2017

    • Author(s)
      藤田 恭之
    • Organizer
      The 15th Stem Cell Research Symposium
    • Related Report
      2017 Research-status Report
    • Invited
  • [Presentation] 細胞競合を利用した新規がん予防的治療薬の開発2017

    • Author(s)
      藤田 恭之
    • Organizer
      日本ケミカルバイオロジー学会第12回年会
    • Related Report
      2017 Research-status Report
    • Invited
  • [Presentation] Cell competition between Normal and Transformed Epithelial Cells2017

    • Author(s)
      藤田 恭之
    • Organizer
      24th Asia Pacific Cancer Conference (APCC2017)
    • Related Report
      2017 Research-status Report
    • Int'l Joint Research / Invited
  • [Presentation] 細胞競合とWarburg effect2017

    • Author(s)
      藤田 恭之
    • Organizer
      第6回がんと代謝研究会
    • Related Report
      2017 Research-status Report
    • Invited
  • [Presentation] 細胞競合とワールブルグ効果2017

    • Author(s)
      藤田 恭之
    • Organizer
      第42回 日本医用マススペクトル学会年会
    • Related Report
      2017 Research-status Report
    • Invited
  • [Presentation] Cell competition: Cancer-host network in carcinogenesis 細胞競合:発がんにおけるがんー宿主ネットワーク2017

    • Author(s)
      藤田 恭之
    • Organizer
      第76回日本癌学会学術総会
    • Related Report
      2017 Research-status Report
    • Int'l Joint Research / Invited
  • [Presentation] Cell competition between normal and transformed epithelial cells in mammals2017

    • Author(s)
      藤田 恭之
    • Organizer
      CHAMPALIMAUD RESEARCH SYMPOSIUM 2017
    • Related Report
      2017 Research-status Report
    • Int'l Joint Research / Invited
  • [Presentation] Cell Cimpetition between normal and trandformed epithelial cells2017

    • Author(s)
      藤田 恭之
    • Organizer
      12th International Symposium of the Institute Network
    • Related Report
      2017 Research-status Report
    • Invited
  • [Presentation] 細胞競合の分子機構と生理的意義:どこまでわかって何がわからないのか2017

    • Author(s)
      藤田 恭之
    • Organizer
      2017年度 生命科学系学会合同年次大会
    • Related Report
      2017 Research-status Report
    • Int'l Joint Research / Invited
  • [Presentation] Collective cell movement during epithelial morphogenesis2017

    • Author(s)
      倉永英里奈
    • Organizer
      Asia-Pacific Drosophila Research Conference 4
    • Related Report
      2017 Research-status Report
    • Int'l Joint Research / Invited
  • [Presentation] Mechanical perspective of collective cell movement in looping morphogenesis2017

    • Author(s)
      倉永英里奈
    • Organizer
      EMBO workshop"Dynamics of living systems”
    • Related Report
      2017 Research-status Report
    • Int'l Joint Research / Invited
  • [Presentation] Cell competition and Warburg effect2016

    • Author(s)
      藤田 恭之
    • Organizer
      第39回日本分子生物学会年会
    • Place of Presentation
      パシフィコ横浜(横浜市)
    • Year and Date
      2016-11-30
    • Related Report
      2016 Research-status Report
    • Int'l Joint Research / Invited
  • [Presentation] Cell competition and Warburg effect2016

    • Author(s)
      藤田 恭之
    • Organizer
      Cell Competition, Apoptosis and Cancer
    • Place of Presentation
      Fundacion Ramon Areces, Spain
    • Year and Date
      2016-10-25
    • Related Report
      2016 Research-status Report
    • Int'l Joint Research / Invited
  • [Presentation] 細胞競合がもたらすワーブルグ効果様の代謝変化2016

    • Author(s)
      藤田 恭之
    • Organizer
      第75回日本癌学会学術総会
    • Place of Presentation
      パシフィコ横浜(横浜市)
    • Year and Date
      2016-10-06
    • Related Report
      2016 Research-status Report
    • Int'l Joint Research / Invited
  • [Presentation] EDAC(Epitherial Defence Against Cancer)2016

    • Author(s)
      藤田 恭之
    • Organizer
      第25回日本Cell Death 学会学術集会
    • Place of Presentation
      きゅりあん(品川区立総合区民会館)(東京都品川区)
    • Year and Date
      2016-09-10
    • Related Report
      2016 Research-status Report
    • Int'l Joint Research / Invited
  • [Presentation] Cell competition in mammalian carcinogenesis2016

    • Author(s)
      藤田 恭之
    • Organizer
      CELL COMPETITION IN FLIES AND MICE in The Allied Genetics Conference 2016
    • Place of Presentation
      Orlando World Center Marriott, USA
    • Year and Date
      2016-07-13
    • Related Report
      2016 Research-status Report
    • Int'l Joint Research / Invited
  • [Remarks] 北海道大学 遺伝子病制御研究所 分子腫瘍分野

    • URL

      http://www.igm.hokudai.ac.jp/oncology/index.html

    • Related Report
      2018 Annual Research Report
  • [Remarks] 北海道大学 遺伝子病制御研究所 分子腫瘍分野のホームページ

    • URL

      http://www.igm.hokudai.ac.jp/oncology/

    • Related Report
      2015 Research-status Report
  • [Patent(Industrial Property Rights)] トランスジェニック非ヒト哺乳動物及び該動物を用いたがん治療薬のスクリーニング方法2016

    • Inventor(s)
      藤田 恭之
    • Industrial Property Rights Holder
      藤田 恭之
    • Industrial Property Rights Type
      特許
    • Industrial Property Number
      2016-054719
    • Filing Date
      2016-03-18
    • Related Report
      2015 Research-status Report

URL: 

Published: 2015-11-10   Modified: 2022-10-18  

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