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Promotion of oxygen biology on the basis of international networks

International Activities Supporting Group

Project AreaOxygen biology: a new criterion for integrated understanding of life
Project/Area Number 15K21759
Research Category

Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)

Allocation TypeMulti-year Fund
Review Section Biological Sciences
Research InstitutionKyoto University

Principal Investigator

Mori Yasuo  京都大学, 工学研究科, 教授 (80212265)

Co-Investigator(Kenkyū-buntansha) 山本 雅之  東北大学, 医学系研究科, 教授 (50166823)
南学 正臣  東京大学, 医学部附属病院, 教授 (90311620)
武田 憲彦  東京大学, 医学部附属病院, 助教 (40422307)
井上 正宏  地方独立行政法人大阪府立病院機構大阪国際がんセンター(研究所), その他部局等, 特別研究員 (10342990)
赤池 孝章  東北大学, 医学系研究科, 教授 (20231798)
西田 基宏  大学共同利用機関法人自然科学研究機構(新分野創成センター、アストロバイオロジーセンター、生命創成探究, 生命創成探究センター, 教授 (90342641)
浦野 泰照  東京大学, 大学院薬学系研究科(薬学部), 教授 (20292956)
飛田 成史  群馬大学, 大学院理工学府, 教授 (30164007)
中川 秀彦  名古屋市立大学, 大学院薬学研究科, 教授 (80281674)
Research Collaborator MIKI hiroaki  
MIURA kyoko  
SUMIMOTO hideki  
ITOH ken  
UCHIDA kouji  
Project Period (FY) 2015-11-06 – 2019-03-31
Project Status Completed (Fiscal Year 2018)
Budget Amount *help
¥58,110,000 (Direct Cost: ¥44,700,000、Indirect Cost: ¥13,410,000)
Fiscal Year 2018: ¥16,380,000 (Direct Cost: ¥12,600,000、Indirect Cost: ¥3,780,000)
Fiscal Year 2017: ¥16,380,000 (Direct Cost: ¥12,600,000、Indirect Cost: ¥3,780,000)
Fiscal Year 2016: ¥16,380,000 (Direct Cost: ¥12,600,000、Indirect Cost: ¥3,780,000)
Fiscal Year 2015: ¥8,970,000 (Direct Cost: ¥6,900,000、Indirect Cost: ¥2,070,000)
Keywords酸素 / 活性酸素種 / 細胞シグナル / イメージング / センサー / 酸素生物学
Outline of Final Research Achievements

Our innovative area "Oxygen Biology" was able to make significant accomplishments in two different aspects. The first is to establish international networks, which form bases to enhance the recognition of our research accomplishments. More specifically, we edited a special issue "Oxygen Physiology: sensors and ion channels" (January issue of 2015), in which leaders of the field including members of our innovative area "Oxygen Biology" contributed reviews, for Pflugers Archiv. - European Journal of Physiology, the internationally recognized journal in the field of physiology. The second is the support to individual international collaborations, which were carried out among members of the innovative area together and the laboratories in universities and research institutes in Europe, north America, and Asia. Obtained data were summarized and published as papers in international journals.

Academic Significance and Societal Importance of the Research Achievements

当該領域は大きく変化、拡大しており、組織を有機的に編成しなければ、相互連携が取りにくい分散的状況にあった。しかし、本領域の活動により、この解決に向けた大きな一歩を踏み出すことができた。また、国際活動支援班を介した本領域での異分野の世界的な統合・再構築は、世界における学術レベルと日本のプレゼンスを格段に向上・強化する。本領域は基礎生物学、医科学、薬学、農学を含めた幅広い分野に関係し、臨床医学、医工学、食品・発酵化、環境科学やケミカルバイオロジーといった学際・応用分野の発展にも結び付く。さらに、共通のプラットフォームである酸素生物学に多様な世代が世界中から集結することは、人材育成に結実する。

Report

(5 results)
  • 2018 Annual Research Report   Final Research Report ( PDF )
  • 2017 Research-status Report
  • 2016 Research-status Report
  • 2015 Research-status Report
  • Research Products

    (49 results)

All 2019 2018 2017 2016 2015 Other

All Int'l Joint Research (24 results) Journal Article (22 results) (of which Int'l Joint Research: 21 results,  Peer Reviewed: 22 results,  Open Access: 17 results,  Acknowledgement Compliant: 5 results) Remarks (2 results) Funded Workshop (1 results)

  • [Int'l Joint Research] Harvard大学/Michigan大学/Sonoma州立大学(米国)

    • Related Report
      2018 Annual Research Report
  • [Int'l Joint Research] London大学Kings College(英国)

    • Related Report
      2018 Annual Research Report
  • [Int'l Joint Research] Sevilla大学(スペイン)

    • Related Report
      2018 Annual Research Report
  • [Int'l Joint Research] Monash大学(オーストラリア)

    • Related Report
      2018 Annual Research Report
  • [Int'l Joint Research] Achen大学(ドイツ)

    • Related Report
      2018 Annual Research Report
  • [Int'l Joint Research]

    • Related Report
      2018 Annual Research Report
  • [Int'l Joint Research] Harvard大学/Texas大学/Michigan大学(米国)

    • Related Report
      2017 Research-status Report
  • [Int'l Joint Research] Instituto de Biomedicina de Sevilla(スペイン)

    • Related Report
      2017 Research-status Report
  • [Int'l Joint Research] Zurich大学(スイス)

    • Related Report
      2017 Research-status Report
  • [Int'l Joint Research] Malaysia Sabah大学(マレーシア)

    • Related Report
      2017 Research-status Report
  • [Int'l Joint Research] London大学/Dundee大学/Southampton大学(英国)

    • Related Report
      2017 Research-status Report
  • [Int'l Joint Research]

    • Related Report
      2017 Research-status Report
  • [Int'l Joint Research] Karolinska Institute(スウェーデン)

    • Related Report
      2016 Research-status Report
  • [Int'l Joint Research] University of Pittsburgh/University of Michigan/The Scripps Research Institute(米国)

    • Related Report
      2016 Research-status Report
  • [Int'l Joint Research] サバ大学/マレーシア大学(マレーシア)

    • Related Report
      2016 Research-status Report
  • [Int'l Joint Research] University of Southampton/University of Birmingham/Queen Mary University of London(英国)

    • Related Report
      2016 Research-status Report
  • [Int'l Joint Research] Uppsala大学/Karolinska Institute(スウェーデン)

    • Related Report
      2016 Research-status Report
  • [Int'l Joint Research]

    • Related Report
      2016 Research-status Report
  • [Int'l Joint Research] University Joseph Fourier(France)

    • Related Report
      2015 Research-status Report
  • [Int'l Joint Research] Harvard University/University of Pittsburgh/University of Michigan(米国)

    • Related Report
      2015 Research-status Report
  • [Int'l Joint Research] Amrita University(India)

    • Related Report
      2015 Research-status Report
  • [Int'l Joint Research] Tronto Western Hospital(Canada)

    • Related Report
      2015 Research-status Report
  • [Int'l Joint Research] University of Sevilla(Spain)

    • Related Report
      2015 Research-status Report
  • [Int'l Joint Research]

    • Related Report
      2015 Research-status Report
  • [Journal Article] Polysulfide stabilization by tyrosine and hydroxyphenyl-containing derivatives that is important for a reactive sulfur metabolomics analysis.2019

    • Author(s)
      Hamid HA, Tanaka A, Ida T, Nishimura A, Matsunaga T, Fujii S, Morita M, Sawa T, Fukuto JM, Nagy P, Tsutsumi R, Motohashi H, Ihara H, Akaike T.
    • Journal Title

      Redox Biol

      Volume: 21 Pages: 101096-101096

    • DOI

      10.1016/j.redox.2019.101096

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Cancer cells co-opt the neuronal redox-sensing channel TRPA1 to promote oxidative-stress tolerance.2018

    • Author(s)
      Takahashi N, Chen HY, Harris IS, Stover DG, Selfors LM, Bronson RT, Deraedt T, Cichowski K, Welm AL, Mori Y, Mills GB, Brugge JS
    • Journal Title

      Cancer Cell

      Volume: 33 Issue: 6 Pages: 985-1003

    • DOI

      10.1016/j.ccell.2018.05.001

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Prolonged stimulation of β2-adrenergic receptor with β2-agonists impairs insulin actions in H9c2 cells2018

    • Author(s)
      Parichatikanond Warisara、Nishimura Akiyuki、Nishida Motohiro、Mangmool Supachoke
    • Journal Title

      Journal of Pharmacological Sciences

      Volume: 138 Issue: 3 Pages: 184-191

    • DOI

      10.1016/j.jphs.2018.09.007

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] TRPC5-eNOS Axis Negatively Regulates ATP-Induced Cardiomyocyte Hypertrophy.2018

    • Author(s)
      Sunggip C, Shimoda K, Oda S, Tanaka T, Nishiyama K, Mangmool S, Nishimura A, Numaga-Tomita T and Nishida M
    • Journal Title

      Front. Pharmacol.

      Volume: 9 Pages: 523-523

    • DOI

      10.3389/fphar.2018.00523

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Biological hydropersulfides and related polysulfides - a new concept and perspective in redox biology2018

    • Author(s)
      Fukuto Jon M.、Ignarro Louis J.、Nagy Peter、Wink David A.、Kevil Christopher G.、Feelisch Martin、Cortese-Krott Miriam M.、Bianco Christopher L.、Kumagai Yoshito、Hobbs Adrian J.、Lin Joseph、Ida Tomoaki、Akaike Takaaki
    • Journal Title

      FEBS Letters

      Volume: 592 Issue: 12 Pages: 2140-2152

    • DOI

      10.1002/1873-3468.13090

    • NAID

      120007133961

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] The reaction of hydrogen sulfide with disulfides: formation of a stable trisulfide and implications for biological systems2018

    • Author(s)
      Bianco Christopher L、Akaike Takaaki、Ida Tomoaki、Nagy Peter、Bogdandi Virag、Toscano John P、Kumagai Yoshito、Henderson Catherine F、Goddu Robert N、Lin Joseph、Fukuto Jon M
    • Journal Title

      British Journal of Pharmacology

      Volume: 176 Issue: 4 Pages: 671-683

    • DOI

      10.1111/bph.14372

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] HIF-dependent and reversible nucleosome disassembly in hypoxia-inducible gene promoters.2018

    • Author(s)
      Suzuki N, Vojnovic N, Lee KL, Yang H, Gradin K, Poellinger L
    • Journal Title

      Exp. Cell Res.

      Volume: 366 Pages: 181-191

    • Related Report
      2017 Research-status Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Cysteine perthiosulfenic acid (Cys-SSOH): A novel intermediate in thiol-based redox signaling?2018

    • Author(s)
      Heppner DE, Hristova M, Ida T, Mijuskovic A, Dustin CM, Bogdandi V, Fukuto JM, Dick TP, Nagy P, Li J, Akaike T, van der Vliet A.
    • Journal Title

      Redox Biol.

      Volume: 14 Pages: 379-385

    • DOI

      10.1016/j.redox.2017.10.006

    • Related Report
      2017 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] N-Acetyl Cysteine Functions as a Fast-Acting Antioxidant by Triggering Intracellular H2S and Sulfane Sulfur Production2018

    • Author(s)
      Ezerina D, Takano Y, Hanaoka K, Urano Y, Dick TP
    • Journal Title

      Cell Chem Biol.

      Volume: 25 Issue: 4 Pages: 447-459

    • DOI

      10.1016/j.chembiol.2018.01.011

    • Related Report
      2017 Research-status Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] The distinct metabolic phenotype of lung squamous cell carcinoma defines selective vulnerability to glycolytic inhibition.2017

    • Author(s)
      Goodwin J, Neugent ML, Lee SY, Choe JH, Choi H, Jenkins DMR, Ruthenborg RJ, Robinson MW, Jeong JY, Wake M, Abe H, Takeda N, Endo H, Inoue M, Xuan Z, Yoo H, Chen M, Ahn JM, Minna JD, Helke KL, Singh PK, Shackelford DB, Kim JW.
    • Journal Title

      Nature Communications

      Volume: 8 Issue: 1 Pages: 15503-15503

    • DOI

      10.1038/ncomms15503

    • Related Report
      2017 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Loss of HIF-1α in natural killer cells inhibits tumour growth by stimulating non-productive angiogenesis.2017

    • Author(s)
      Krzywinska E, Kantari-Mimoun C, Kerdiles Y, Sobecki M, Isagawa T, Gotthardt D, Castells M, Haubold J, Millien C, Viel T, Tavitian B, Takeda N, Fandrey J, Vivier E, Sexl V, Stockmann C.
    • Journal Title

      Nat Commun

      Volume: 8 Issue: 1 Pages: 1597-1597

    • DOI

      10.1038/s41467-017-01599-w

    • Related Report
      2017 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Stimulation of Adenosine A2B Receptor Inhibits Endothelin-1-Induced Cardiac Fibroblast Proliferation and α-Smooth Muscle Actin Synthesis Through the cAMP/Epac/PI3K/Akt-Signaling Pathway2017

    • Author(s)
      Phosri Sarawuth、Arieyawong Ajaree、Bunrukchai Kwanchai、Parichatikanond Warisara、Nishimura Akiyuki、Nishida Motohiro、Mangmool Supachoke
    • Journal Title

      Frontiers in Pharmacology

      Volume: 8 Pages: 428-428

    • DOI

      10.3389/fphar.2017.00428

    • Related Report
      2017 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Purinergic P2Y6 receptors: a new therapeutic target of age-dependent hypertension2017

    • Author(s)
      Sunggip C, Nishimura A, Shimoda K, Numaga-Tomita T, Tsuda M, and Nishida M. M
    • Journal Title

      Pharmacological Research

      Volume: 120 Pages: 51-59

    • DOI

      10.1016/j.phrs.2017.03.013

    • Related Report
      2017 Research-status Report 2016 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Regulation of hypoxia-inducible gene expression after HIF activation.2017

    • Author(s)
      Suzuki N, Gradin K, Poellinger L, Yamamoto M.
    • Journal Title

      Exp. Cell Res.

      Volume: 356 Pages: 182-186

    • Related Report
      2017 Research-status Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Cysteinyl-tRNA synthetase governs cysteine polysulfidation and mitochondrial bioenergetics2017

    • Author(s)
      Akaike Takaaki、、、Nishida Motohiro(4)、、、、、、Fujii Shigemoto(20)、、、Motohashi Hozumi(26)
    • Journal Title

      Nature Communications

      Volume: 8 Issue: 1 Pages: 1177-1177

    • DOI

      10.1038/s41467-017-01311-y

    • NAID

      120007134656

    • Related Report
      2017 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Derepression of the DNA Methylation Machinery of the <i>Gata1</i> Gene Triggers the Differentiation Cue for Erythropoiesis2017

    • Author(s)
      Yu L, Takai J, Otsuki A, Katsuoka F, Suzuki M, Katayama S, Nezu M, Engel JD, Moriguchi T, Yamamoto M.
    • Journal Title

      Mol Cell Biol

      Volume: 37 Issue: 8 Pages: 592-616

    • DOI

      10.1128/mcb.00592-16

    • Related Report
      2016 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] Generation of a new model rat: Nrf2 knockout rats are sensitive to aflatoxin B1 toxicity.2016

    • Author(s)
      Taguchi K, Takaku M, Egner PA, Morita M, Kaneko T, Mashimo T, Kensler TW, Yamamoto M.
    • Journal Title

      Toxicol Sci

      Volume: in press Issue: 1 Pages: 40-52

    • DOI

      10.1093/toxsci/kfw065

    • Related Report
      2016 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] The chemicall biology of protein hydropersulfides: Studies of a possible protective function of biological hydropersulfide generateon.2016

    • Author(s)
      Millikin R, Bianco CL, White C, Saund SS, Henriquez S, Sosa V, Akaike T, Kumagai Y, Soeda S, Toscano JP, Lin J, Fukuto JM.
    • Journal Title

      Free Radical Biology and Medicine

      Volume: 97 Pages: 136-147

    • DOI

      10.1016/j.freeradbiomed.2016.05.013

    • Related Report
      2016 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Redox-sensitive transient receptor potential channels in oxygen sensing and adaptation.2016

    • Author(s)
      Mori Y, Takahashi N, Polat OK, Kuroakwa T, Takeda N, Inoue M
    • Journal Title

      Pflugers Arch. Eur. J. Physiol.

      Volume: 468 Issue: 1 Pages: 85-97

    • DOI

      10.1007/s00424-015-1716-2

    • NAID

      120005980858

    • Related Report
      2015 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] Roles of renal erythropoietin-producing (REP) cells in the maintenance of systemic oxygen homeostasis.2016

    • Author(s)
      Suzuki N, Yamamoto M
    • Journal Title

      Pflugers Arch. Eur. J. Physiol.

      Volume: 468 Issue: 1 Pages: 3-12

    • DOI

      10.1007/s00424-015-1740-2

    • Related Report
      2015 Research-status Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Oxygen physiology: sensors and ion channels2016

    • Author(s)
      Mori Y, Takahashi N, Ogawa N, Gudermann T
    • Journal Title

      Pflugers Arch.Eur. J. Physiol.

      Volume: 468 Issue: 1 Pages: 1-2

    • DOI

      10.1007/s00424-015-1762-9

    • Related Report
      2015 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] Thiosulfate mediates cytoprotective effects of hydrogen sulfide against neuronal ischemia2015

    • Author(s)
      Marutani E, Yamada M, Ida T, Tokuda K, Ikeda K, Kai S, Shirozu K, Hayashida K, Kosugi S, Hanaoka K, Kaneki M, Akaike T, Ichinose F
    • Journal Title

      J Am Heart Assoc

      Volume: 4 Issue: 11

    • DOI

      10.1161/jaha.115.002125

    • Related Report
      2015 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Remarks]

    • Related Report
      2018 Annual Research Report
  • [Remarks] 新学術領域研究「酸素生物学」

    • URL

      http://www.oxygenbiology.net/

    • Related Report
      2016 Research-status Report 2015 Research-status Report
  • [Funded Workshop] WCP2018 KYOTO satellite symposium: Regulating cell homeostasis: from small molecules (drugs, O2, ROS, and NO) to ion channels, receptors, and systems.2018

    • Related Report
      2018 Annual Research Report

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Published: 2015-11-10   Modified: 2022-10-18  

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