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Integrative understanding of biological signaling networks based on mathematical science

International Activities Supporting Group

Project AreaIntegrative understanding of biological signaling networks based on mathematical science
Project/Area Number 16K21739
Research Category

Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)

Allocation TypeMulti-year Fund
Review Section Complex systems
Research InstitutionThe University of Tokyo

Principal Investigator

Takekawa Mutsuhiro  東京大学, 医科学研究所, 教授 (30322332)

Co-Investigator(Kenkyū-buntansha) 鈴木 貴  大阪大学, 数理・データ科学教育研究センター, 特任教授(常勤) (40114516)
井上 純一郎  東京大学, 医科学研究所, 特任研究員 (70176428)
Project Period (FY) 2016-06-30 – 2023-03-31
Project Status Completed (Fiscal Year 2022)
Budget Amount *help
¥13,650,000 (Direct Cost: ¥10,500,000、Indirect Cost: ¥3,150,000)
Fiscal Year 2020: ¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2019: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2018: ¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2017: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2016: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Keywordsシグナル伝達 / 数理科学 / 情報科学 / シミュレーション / オミクス / 数理モデル / 数理解析 / 生体分子 / ネットワーク
Outline of Final Research Achievements

The International Activities Support Group has promoted international research and personnel exchanges mainly through four-country exchanges with internationally renowned research institutions that specialize in mathematical biology and medicine: Vanderbilt University (USA), St. Andrews University (UK), and the INRIA Southwest Research Center in Bordeaux (France). Collaborations have been conducted on mathematical models and simulations of biological signaling, their applications in life and medical sciences, and statistical experimental validation. Furthermore, academic exchanges were expanded to include other Asian countries such as China and Korea. We organized international academic conferences (both on-site and online), accepted international students, hired post-doctoral researchers, and facilitated short- and mid-term international assignments for young researchers.

Academic Significance and Societal Importance of the Research Achievements

国際活動支援班の活動により、日米英仏の4カ国を中心に本領域の研究者(若手を含む)と海外の第一線の研究者との学術的交流および人材交流が積極的に行われ、各国の先進的研究機関との共同研究が発展・深化した。この連携は当該分野で世界最高レベルのものであり、長期的な国際協働体制を構築して国内外で成果を発信しており、研究者コミュニティを先導するものとなっている。

Report

(8 results)
  • 2022 Annual Research Report   Final Research Report ( PDF )
  • 2021 Research-status Report
  • 2020 Research-status Report
  • 2019 Research-status Report
  • 2018 Research-status Report
  • 2017 Research-status Report
  • 2016 Research-status Report
  • Research Products

    (243 results)

All 2023 2022 2021 2020 2019 2018 2017 2016 Other

All Int'l Joint Research (29 results) Journal Article (36 results) (of which Int'l Joint Research: 7 results,  Peer Reviewed: 35 results,  Open Access: 26 results,  Acknowledgement Compliant: 2 results) Presentation (170 results) (of which Int'l Joint Research: 22 results,  Invited: 41 results) Remarks (5 results) Funded Workshop (3 results)

  • [Int'l Joint Research] MD Anderson Cancer Center/Vanderbilt University/Johns Hopkins School of Medicine(米国)

    • Related Report
      2022 Annual Research Report
  • [Int'l Joint Research] セントアンドリューズ大学(英国)

    • Related Report
      2022 Annual Research Report
  • [Int'l Joint Research] INRIAボルドー南西研究センター(フランス)

    • Related Report
      2022 Annual Research Report
  • [Int'l Joint Research] German Cancer Research Center(ドイツ)

    • Related Report
      2022 Annual Research Report
  • [Int'l Joint Research] セントアンドリューズ大学(英国)

    • Related Report
      2021 Research-status Report
  • [Int'l Joint Research] Johns Hopkins School of Medicine/Vanderbilt University/MD Anderson Cancer Center(米国)

    • Related Report
      2021 Research-status Report
  • [Int'l Joint Research] INRIAボルドー南西研究センター(フランス)

    • Related Report
      2021 Research-status Report
  • [Int'l Joint Research] German Cancer Research Center(ドイツ)

    • Related Report
      2021 Research-status Report
  • [Int'l Joint Research] Johns Hopkins School of Medicine/MD Anderson Cancer Center/Vanderbilt University(米国)

    • Related Report
      2020 Research-status Report
  • [Int'l Joint Research] セントアンドリューズ大学(英国)

    • Related Report
      2020 Research-status Report
  • [Int'l Joint Research] INRIAボルドー南西研究センター(フランス)

    • Related Report
      2020 Research-status Report
  • [Int'l Joint Research] German Cancer Research Center(ドイツ)

    • Related Report
      2020 Research-status Report
  • [Int'l Joint Research] German Cancer Research Center(ドイツ)

    • Related Report
      2019 Research-status Report
  • [Int'l Joint Research] Johns Hopkins School of Medicine/MD Anderson Cancer Center/Vanderbilt University(米国)

    • Related Report
      2019 Research-status Report
  • [Int'l Joint Research] セントアンドリューズ大学(英国)

    • Related Report
      2019 Research-status Report
  • [Int'l Joint Research] INRIAボルドー南西研究セン ター(フランス)

    • Related Report
      2019 Research-status Report
  • [Int'l Joint Research] German Cancer Research Center(ドイツ)

    • Related Report
      2018 Research-status Report
  • [Int'l Joint Research] Johns Hopkins School of Medicine/MD Anderson Cancer Center/Vanderbilt University(米国)

    • Related Report
      2018 Research-status Report
  • [Int'l Joint Research] セントアンドリューズ大学(英国)

    • Related Report
      2018 Research-status Report
  • [Int'l Joint Research] INRIAボルドー南西研究センター(フランス)

    • Related Report
      2018 Research-status Report
  • [Int'l Joint Research] University Clinic Munster(Germany)

    • Related Report
      2017 Research-status Report
  • [Int'l Joint Research] ヴァンダービルト大学/M.D. Anderson Cancer Center/Johns Hopkins University(米国)

    • Related Report
      2017 Research-status Report
  • [Int'l Joint Research] セントアンドリューズ大学(英国)

    • Related Report
      2017 Research-status Report
  • [Int'l Joint Research] INRIAボルドー南西研究セン ター(フランス)

    • Related Report
      2017 Research-status Report
  • [Int'l Joint Research] 中国科学院、微生物研究所・生物物理研究所(中国)

    • Related Report
      2017 Research-status Report
  • [Int'l Joint Research] ヴァンダービルト大学/Cincinnati Children's Hospital/National Cancer Institute, NIH(米国)

    • Related Report
      2016 Research-status Report
  • [Int'l Joint Research] セントアンドリューズ大学(英国)

    • Related Report
      2016 Research-status Report
  • [Int'l Joint Research] INRIAボルドー南西研究センター(フランス)

    • Related Report
      2016 Research-status Report
  • [Int'l Joint Research] 中国科学院、微生物研究所・生物物理研究所(中国)

    • Related Report
      2016 Research-status Report
  • [Journal Article] Caspase 3‐specific cleavage of MEK1 suppresses ERK signaling and sensitizes cells to stress‐induced apoptosis2023

    • Author(s)
      Moriizumi Hisashi、Kubota Yuji、Tsuchiya Tomoyuki、Naka Ryosuke、Takekawa Mutsuhiro
    • Journal Title

      FEBS Open Bio

      Volume: 13 Issue: 4 Pages: 684-700

    • DOI

      10.1002/2211-5463.13574

    • Related Report
      2022 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Involvement of clusterin expression in the refractory response of pancreatic cancer cells to a MEK inhibitor.2023

    • Author(s)
      Amada K, Hijiya N, Ikarimoto S, Yanagihara K, Hanada T, Hidano S, Kurogi S, Tsukamoto Y, Nakada C, Kinoshita K, Hirashita Y, Uchida T, Shin T, Yada K, Hirashita T, Kobayashi T, Murakami K, Inomata M, Shirao K, Aoki M, Takekawa M, Moriyama M.
    • Journal Title

      Cancer Sci.

      Volume: 114 Issue: 5 Pages: 2189-2202

    • DOI

      10.1111/cas.15735

    • Related Report
      2022 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Stress granule formation inhibits stress-induced apoptosis by selectively sequestering executioner caspases.2023

    • Author(s)
      Fujikawa D, Nakamura T, Yoshioka D, Li Z, Moriizumi H, Taguchi M, Tokai-Nishizumi N, Kozuka-Hata H, Oyama M, and Takekawa M
    • Journal Title

      Current Biology

      Volume: -

    • Related Report
      2022 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Enhanced phosphorylation of c-Jun by cisplatin treatment as a potential predictive biomarker for cisplatin response in combination with patient-derived tumor organoids.2022

    • Author(s)
      Tsukamoto Y, Kurogi S, Shibata T, Suzuki K, Hirashita Y, Fumoto S, Yano S, Yanagihara K, Nakada C, Mieno F, Kinoshita K, Fuchino T, Mizukami K, Ueda Y, Etoh T, Uchida T, Hanada T, Takekawa M, Daa T, Shirao K, Hironaka S, Murakami K, Inomata M, Hijiya N, Moriyama M.
    • Journal Title

      Lab Invest.

      Volume: 102 (12) Issue: 12 Pages: 1355-1366

    • DOI

      10.1038/s41374-022-00827-2

    • Related Report
      2022 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Qualitative differences in disease-associated MEK mutants reveal molecular signatures and aberrant signaling-crosstalk in cancer2022

    • Author(s)
      Kubota Yuji、Fujioka Yuko、Patil Ashwini、Takagi Yusuke、Matsubara Daisuke、Iijima Masatomi、Momose Isao、Naka Ryosuke、Nakai Kenta、Noda Nobuo N.、Takekawa Mutsuhiro
    • Journal Title

      Nature Communications

      Volume: 13 Issue: 1 Pages: 4063-4063

    • DOI

      10.1038/s41467-022-31690-w

    • Related Report
      2022 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] ERK-mediated NELF-A phosphorylation promotes transcription elongation of immediate-early genes by releasing promoter-proximal pausing of RNA polymerase II2022

    • Author(s)
      Ohe Seina、Kubota Yuji、Yamaguchi Kiyoshi、Takagi Yusuke、Nashimoto Junichiro、Kozuka-Hata Hiroko、Oyama Masaaki、Furukawa Yoichi、Takekawa Mutsuhiro
    • Journal Title

      Nature Communications

      Volume: 13 Issue: 1 Pages: 7476-7476

    • DOI

      10.1038/s41467-022-35230-4

    • Related Report
      2022 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Multicellular model of angiogenesis2022

    • Author(s)
      Nakazawa Takashi、Tasaki Sohei、Nakai Kiyohiko、Suzuki Takashi
    • Journal Title

      AIMS Bioengineering

      Volume: 9 Issue: 1 Pages: 44-60

    • DOI

      10.3934/bioeng.2022004

    • Related Report
      2021 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] ストレス顆粒形成による生命機能制御と疾患2021

    • Author(s)
      吉岡 大介、中村 貴紀、武川 睦寛
    • Journal Title

      実験医学増刊 相分離 メカニズムと疾患

      Volume: 39 Pages: 93-101

    • Related Report
      2021 Research-status Report
    • Peer Reviewed
  • [Journal Article] Level set method for free boundary of invasive cancer cell using different functions of matrix metalloproteinases2021

    • Author(s)
      Yaacob Noorehan、Shafie Sharidan、Suzuki Takashi、Admon Mohd Ariff
    • Journal Title

      Journal of Physics: Conference Series

      Volume: 1988 Issue: 1 Pages: 012020-012020

    • DOI

      10.1088/1742-6596/1988/1/012020

    • Related Report
      2021 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Expression of Cancer Stem Cell Markers EpCAM and CD90 Is Correlated with Anti- and Pro-Oncogenic EphA2 Signaling in Hepatocellular Carcinoma2021

    • Author(s)
      Asakura Nobuhiko、Nakamura Naotoshi、Muroi Atsushi、Nojima Yosui、Yamashita Taro、Kaneko Shuichi、Ikeda Kazuki、Koshikawa Naohiko、Suzuki Takashi
    • Journal Title

      International Journal of Molecular Sciences

      Volume: 22 Issue: 16 Pages: 8652-8652

    • DOI

      10.3390/ijms22168652

    • Related Report
      2021 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] NFAT indicates nucleocytoplasmic damped oscillation via its feedback modulator2021

    • Author(s)
      Muramatsu Masashi、Ito Takeshi、Shimoji Hokuto、Komiya Miko、Miyamura Yuri、Nishiyama Koichi、Suzuki Takashi、Minami Takashi
    • Journal Title

      Biochemical and Biophysical Research Communications

      Volume: 571 Pages: 201-209

    • DOI

      10.1016/j.bbrc.2021.07.072

    • Related Report
      2021 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Quasilinear reaction diffusion systems with mass dissipation2021

    • Author(s)
      Latos Evangelos、Suzuki Takashi
    • Journal Title

      Mathematics in Engineering

      Volume: 4 Issue: 5 Pages: 1-13

    • DOI

      10.3934/mine.2022042

    • Related Report
      2021 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Prohibitin-1 Contributes to Cell-to-Cell Transmission of Herpes Simplex Virus 1 via the MAPK/ERK Signaling Pathway2020

    • Author(s)
      Watanabe Mizuki、Arii Jun、Takeshima Kosuke、Fukui Ayano、Shimojima Masayuki、Kozuka-Hata Hiroko、Oyama Masaaki、Minamitani Takeharu、Yasui Teruhito、Kubota Yuji、Takekawa Mutsuhiro、Kosugi Isao、Maruzuru Yuhei、Koyanagi Naoto、Kato Akihisa、Mori Yasuko、Kawaguchi Yasushi
    • Journal Title

      Journal of Virology

      Volume: 95 Issue: 3

    • DOI

      10.1128/jvi.01413-20

    • Related Report
      2021 Research-status Report 2020 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Stress-responsive MTK1 SAPKKK serves as a redox sensor that mediates delayed and sustained activation of SAPKs by oxidative stress2020

    • Author(s)
      Matsushita Moe、Nakamura Takanori、Moriizumi Hisashi、Miki Hiroaki、Takekawa Mutsuhiro
    • Journal Title

      Science Advances

      Volume: 6 Issue: 26 Pages: 1-1

    • DOI

      10.1126/sciadv.aay9778

    • Related Report
      2020 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] The Anticoagulant Nafamostat Potently Inhibits SARS-CoV-2 S Protein-Mediated Fusion in a Cell Fusion Assay System and Viral Infection In Vitro in a Cell-Type-Dependent Manner2020

    • Author(s)
      Yamamoto Mizuki、Kiso Maki、Sakai-Tagawa Yuko、Iwatsuki-Horimoto Kiyoko、Imai Masaki、Takeda Makoto、Kinoshita Noriko、Ohmagari Norio、Gohda Jin、Semba Kentaro、Matsuda Zene、Kawaguchi Yasushi、Kawaoka Yoshihiro、Inoue Jun-ichiro
    • Journal Title

      Viruses

      Volume: 12 Issue: 6 Pages: 629-629

    • DOI

      10.3390/v12060629

    • Related Report
      2020 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] EXOSC9 depletion attenuates P-body formation, stress resistance, and tumorigenicity of cancer cells.2020

    • Author(s)
      Yoshino S, Matsui Y, Fukui Y, Seki M, Yamaguchi K, Kanamori A, Saitoh Y, Shimamura T, Suzuki Y, Furukawa Y, Kaneko S, Seiki M, Murakami Y, Inoue JI, Sakamoto T.
    • Journal Title

      Sci Rep

      Volume: 10 Issue: 1 Pages: 9275-9275

    • DOI

      10.1038/s41598-020-66455-2

    • Related Report
      2020 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] TIFAB Regulates USP15-Mediated p53 Signaling during Stressed and Malignant Hematopoiesis2020

    • Author(s)
      Niederkorn Madeline、Hueneman Kathleen、Choi Kwangmin、Varney Melinda E.、Romano Laurel、Pujato Mario A.、Greis Kenneth D.、Inoue Jun-ichiro、Meetei Ruhikanta、Starczynowski Daniel T.
    • Journal Title

      Cell Reports

      Volume: 30 Issue: 8 Pages: 2776-2790.e6

    • DOI

      10.1016/j.celrep.2020.01.093

    • Related Report
      2020 Research-status Report 2019 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] System-Wide Analysis of Protein Acetylation and Ubiquitination Reveals a Diversified Regulation in Human Cancer Cells2020

    • Author(s)
      Kozuka-Hata Hiroko、Kitamura Aya、Hiroki Tomoko、Aizawa Aiko、Tsumoto Kouhei、Inoue Jun-ichiro、Oyama Masaaki
    • Journal Title

      Biomolecules

      Volume: 10 Issue: 3 Pages: 411-411

    • DOI

      10.3390/biom10030411

    • Related Report
      2020 Research-status Report 2019 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Structural analysis of TIFA: Insight into TIFA-dependent signal transduction in innate immunity2020

    • Author(s)
      Nakamura Teruya、Hashikawa Chie、Okabe Kohtaro、Yokote Yuya、Chirifu Mami、Toma-Fukai Sachiko、Nakamura Narushi、Matsuo Mihoko、Kamikariya Miho、Okamoto Yoshinari、Gohda Jin、Akiyama Taishin、Semba Kentaro、Ikemizu Shinji、Otsuka Masami、Inoue Jun-ichiro、Yamagata Yuriko
    • Journal Title

      Scientific Reports

      Volume: 10 Issue: 1 Pages: 5152-5152

    • DOI

      10.1038/s41598-020-61972-6

    • Related Report
      2020 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Stress-responsive MTK1 SAPKKK serves as a redox sensor that mediates delayed and sustained activation of SAPKs by oxidative stress.2020

    • Author(s)
      Matsushita M, Nakamura T, Moriizumi H, Miki H, and Takekawa M.
    • Journal Title

      Science Advances

      Volume: in press

    • Related Report
      2019 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] MCRIP1 promotes the expression of lung-surfactant proteins in mice by disrupting CtBP-mediated epigenetic gene silencing2019

    • Author(s)
      Weng Jane S.、Nakamura Takanori、Moriizumi Hisashi、Takano Hiroshi、Yao Ryoji、Takekawa Mutsuhiro
    • Journal Title

      Communications Biology

      Volume: 2 Issue: 1 Pages: 227-227

    • DOI

      10.1038/s42003-019-0478-3

    • Related Report
      2019 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] -GlcNAc化蛋白質の検出と定量的解析を可能にするレクチン親和性ゲル電気泳動法の開発と応用2019

    • Author(s)
      久保田裕二、藤岡興、武川睦寛
    • Journal Title

      生物物理化学-電気泳動-

      Volume: 63 Pages: 41-45

    • Related Report
      2019 Research-status Report
    • Peer Reviewed
  • [Journal Article] Impact of spaceflight on the murine thymus and mitigation by exposure to artificial gravity during spaceflight2019

    • Author(s)
      Horie Kenta、Kato Tamotsu、Kudo Takashi、Sasanuma Hiroki、Miyauchi Maki、Akiyama Nobuko、Miyao Takahisa、Seki Takao、Ishikawa Tatsuya、Takakura Yuki、Shirakawa Masaki、Shiba Dai、Hamada Michito、Jeon Hyojung、Yoshida Nobuaki、Inoue Jun-ichiro、Muratani Masafumi、Takahashi Satoru、Ohno Hiroshi、Akiyama Taishin
    • Journal Title

      Scientific Reports

      Volume: 9 Issue: 1 Pages: 19866-19866

    • DOI

      10.1038/s41598-019-56432-9

    • NAID

      120007132915

    • Related Report
      2019 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] TRAF6 maintains mammary stem cells and promotes pregnancy-induced mammary epithelial cell expansion2019

    • Author(s)
      Yamamoto Mizuki、Abe Chiho、Wakinaga Sakura、Sakane Kota、Yumiketa Yo、Taguchi Yuu、Matsumura Takayuki、Ishikawa Kosuke、Fujimoto Jiro、Semba Kentaro、Miyauchi Maki、Akiyama Taishin、Inoue Jun-ichiro
    • Journal Title

      Communications Biology

      Volume: 2 Issue: 1 Pages: 292-292

    • DOI

      10.1038/s42003-019-0547-7

    • Related Report
      2019 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Minimum structural requirements for inhibitors of the zinc finger protein TRAF62019

    • Author(s)
      Radwan Mohamed O.、Koga Ryoko、Hida Tomohiro、Ejima Tomohiko、Kanemaru Yosuke、Tateishi Hiroshi、Okamoto Yoshinari、Inoue Jun-ichiro、Fujita Mikako、Otsuka Masami
    • Journal Title

      Bioorganic & Medicinal Chemistry Letters

      Volume: 29 Issue: 16 Pages: 2162-2167

    • DOI

      10.1016/j.bmcl.2019.06.050

    • Related Report
      2019 Research-status Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Critical roles of IκBα and RelA phosphorylation in transitional oscillation in NF-κB signaling module2019

    • Author(s)
      Hatanaka Naoya、Seki Takao、Inoue Jun-ichiro、Tero Atsushi、Suzuki Takashi
    • Journal Title

      Journal of Theoretical Biology

      Volume: 462 Pages: 479-489

    • DOI

      10.1016/j.jtbi.2018.11.023

    • Related Report
      2018 Research-status Report
    • Peer Reviewed
  • [Journal Article] Wheat Germ Agglutinin (WGA)-SDS-PAGE: A Novel Method for the Detection of O-GlcNAc-modified Proteins by Lectin Affinity Gel Electrophoresis2018

    • Author(s)
      Fujioka Ko、Kubota Yuji、Takekawa Mutsuhiro
    • Journal Title

      BIO-PROTOCOL

      Volume: 8 Issue: 23

    • DOI

      10.21769/bioprotoc.3098

    • Related Report
      2018 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] A guanine derivative as a new MEK inhibitor produced by Streptomyces sp. MK63-43F2.2018

    • Author(s)
      M. Iijima, Yuji Kubota, R. Sawa, Yumiko Kubota, M. Hatano, M. Igarashi, M. Kawada, I. Momose, M. Takekawa, M. Shibasaki.
    • Journal Title

      J. Antibiot.

      Volume: 71 Issue: 1 Pages: 135-138

    • DOI

      10.1038/ja.2017.100

    • Related Report
      2017 Research-status Report
    • Peer Reviewed
  • [Journal Article] Downregulation of dual-specificity phosphatase 4 enhances cell proliferation and invasiveness in colorectal carcinomas2017

    • Author(s)
      Ichimanda Michihiro、Hijiya Naoki、Tsukamoto Yoshiyuki、Uchida Tomohisa、Nakada Chisato、Akagi Tomonori、Etoh Tsuyoshi、Iha Hidekatsu、Inomata Masafumi、Takekawa Mutsuhiro、Moriyama Masatsugu
    • Journal Title

      Cancer Sci

      Volume: 109 Issue: 1 Pages: 250-258

    • DOI

      10.1111/cas.13444

    • Related Report
      2018 Research-status Report 2017 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] WGA-based lectin affinity gel electrophoresis: A novel method for the detection of O-GlcNAc-modified proteins2017

    • Author(s)
      Kubota Yuji、Fujioka Ko、Takekawa Mutsuhiro
    • Journal Title

      PLOS ONE

      Volume: 12 Issue: 7 Pages: e0180714-e0180714

    • DOI

      10.1371/journal.pone.0180714

    • Related Report
      2017 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] TIA1 oxidation inhibits stress granule assembly and sensitizes cells to stress-induced apoptosis.2016

    • Author(s)
      Arimoto-Matsuzaki K, Saito H and Takekawa M.
    • Journal Title

      Nature Commun.

      Volume: 7 Issue: 1

    • DOI

      10.1038/ncomms10252

    • Related Report
      2016 Research-status Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Genomic loss of DUSP4 contributes to the progression of intraepithelial neoplasm of pancreas to invasive carcinoma.2016

    • Author(s)
      Hijiya N, Tsukamoto Y, Nakada C, Tung NL, Kai T, Matsuura K, Shibata K, Inomata M, Uchida T, Tokunaga A, Amada K, Shirao K, Yamada Y, Mori H, Takeuchi I, Seto M, Aoki M, Takekawa M, Moriyama M.
    • Journal Title

      Cancer Res.

      Volume: 76 Issue: 9 Pages: 2612-2625

    • DOI

      10.1158/0008-5472.can-15-1846

    • Related Report
      2016 Research-status Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] A Phos-tag SDS-PAGE method that effectively uses phosphoproteomic data for profiling the phosphorylation dynamics of MEK1.2016

    • Author(s)
      Kinoshita E, Kinoshita-Kikuta E, Kubota Y, Takekawa M and Koike T.
    • Journal Title

      Proteomics

      Volume: 16 Issue: 13 Pages: 1825-1836

    • DOI

      10.1002/pmic.201500494

    • Related Report
      2016 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Detection and functional analysis of SUMO-modified MEK.2016

    • Author(s)
      Kubota Y and Takekawa M.
    • Journal Title

      Methods in Molecular Biology

      Volume: 1487 Pages: 99-111

    • DOI

      10.1007/978-1-4939-6424-6_7

    • ISBN
      9781493964222, 9781493964246
    • Related Report
      2016 Research-status Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] MAPキナーゼ情報伝達経路の活性制御機構と疾患発症機構の解明2016

    • Author(s)
      武川睦寛
    • Journal Title

      生物物理化学 電気泳動

      Volume: 60 Pages: 7-10

    • NAID

      130005249511

    • Related Report
      2016 Research-status Report
    • Peer Reviewed
  • [Journal Article] ストレス顆粒形成によるストレス誘導アポトーシスの制御と活性酸素によるその破綻2016

    • Author(s)
      武川睦寛
    • Journal Title

      生物物理化学 電気泳動

      Volume: 60

    • Related Report
      2016 Research-status Report
  • [Presentation] 1細胞内分子振動と多細胞間相互作用によるストレス応答機構の解明2023

    • Author(s)
      武川睦寛
    • Organizer
      多細胞領域会議
    • Related Report
      2022 Annual Research Report
  • [Presentation] Transcriptional regulation of immediate-early genes by a novel ERK substrate protein and its failure in cancer2023

    • Author(s)
      Mutsuhiro Takekawa
    • Organizer
      OIST seminar
    • Related Report
      2022 Annual Research Report
    • Invited
  • [Presentation] 中心小体輸送の分子基盤と発育不全疾患におけるその破綻2023

    • Author(s)
      中村 貴紀, 西住 紀子, 河西 通, 中澤 崇, 森 竜樹, 武田 洋幸, 鈴木 貴, 武川 睦寛
    • Organizer
      多細胞領域会議
    • Related Report
      2022 Annual Research Report
  • [Presentation] 疾患関連MEK変異体の解析から明らかとなったERK-AKT経路間の癌特異的クロストーク2022

    • Author(s)
      武川睦寛
    • Organizer
      第95回日本生化学会大会
    • Related Report
      2022 Annual Research Report
    • Invited
  • [Presentation] Transcriptional regulation of immediate-early genes by a novel ERK substrate protein and its failure in cancer2022

    • Author(s)
      Mutsuhiro Takekawa
    • Organizer
      MBSJ2022 第45回日本分子生物学会年会
    • Related Report
      2022 Annual Research Report
    • Invited
  • [Presentation] Functional crosstalk between ERK pathway and PP2A phosphatase in the regulation of immediate-early gene expression and its failure in cancer2022

    • Author(s)
      Mutsuhiro Takekawa
    • Organizer
      FASEB Science Research conference "The Protein Phosphatase Conference"
    • Related Report
      2022 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] 中心体複製開始における分子制御機構とがんにおけるその破綻2022

    • Author(s)
      中村 貴紀, 渡海 紀子, 中澤 崇, 森 竜樹, 鈴木 貴, 武川 睦寛
    • Organizer
      第81回 日本癌学会学術総会
    • Related Report
      2022 Annual Research Report
  • [Presentation] 非膜型オルガネラを介した生体内恒常性の制御:その破綻に伴う癌および発育不全疾患の発症機構2022

    • Author(s)
      中村 貴紀, 武川 睦寛
    • Organizer
      愛媛大学プロテオサイエンスセンターPROSセミナー
    • Related Report
      2022 Annual Research Report
    • Invited
  • [Presentation] 酵母を利用したスクリーニング法によるSAPK変異体の単離2022

    • Author(s)
      久保田 裕二, 中 亮介, 武川 睦寛
    • Organizer
      第16回 日本臨床ストレス応答学会大会
    • Related Report
      2022 Annual Research Report
  • [Presentation] Analysis of the expression mechanism and molecular function of an oncogenic ERK-inducible tetraspanin protein in cancer2022

    • Author(s)
      梨本 淳一郎、久保田 裕二、武川 睦寛
    • Organizer
      G2 plus Retreat
    • Related Report
      2022 Annual Research Report
  • [Presentation] Elucidation of the activation mechanism of the p38/JNK pathways induced by oncogenic stress2022

    • Author(s)
      川瀧 紗英子、久保田 裕二、武川 睦寛
    • Organizer
      医科学研究所 研究成果発表会
    • Related Report
      2022 Annual Research Report
  • [Presentation] Mutual regulation between MAPK phosphatases and the ERK pathway2022

    • Author(s)
      齊藤 まりこ、久保田 裕二、武川 睦寛
    • Organizer
      第22回 東京大学 生命科学シンポジウム (BIO-UT)
    • Related Report
      2022 Annual Research Report
  • [Presentation] 新規ERK誘導性遺伝子EIG1による発癌抑制機構の解明2022

    • Author(s)
      高木 祐輔、久保田 裕二、武川 睦寛
    • Organizer
      第81回日本癌学会学術総会
    • Related Report
      2022 Annual Research Report
  • [Presentation] Elucidation of molecular mechanisms of ERK hyper-activation and drug-resistance in cancers with MEK1 mutations2022

    • Author(s)
      久保田 裕二、藤岡 優子、高木 祐介、松原 大祐、飯島 正富、百瀬 功、中井 謙太、野田 展生、武川 睦寛
    • Organizer
      第81回 日本癌学会学術総会
    • Related Report
      2022 Annual Research Report
  • [Presentation] Mutual regulation between MAPK phosphatases and the ERK pathway2022

    • Author(s)
      齊藤 まりこ、久保田 裕二、武川 睦寛
    • Organizer
      第81回 日本癌学会学術総会
    • Related Report
      2022 Annual Research Report
  • [Presentation] p38/JNKにより発現制御されるmiRNA-Xは大腸癌においてアポトーシスを抑制する2022

    • Author(s)
      渡海 紀子、中村 貴紀、武川 睦寛
    • Organizer
      第45回日本分子生物学会年会
    • Related Report
      2022 Annual Research Report
  • [Presentation] Analysis of gene expression profiles conferred by different Ras mutations derived from cancer or congenital diseases2022

    • Author(s)
      王 かく、久保田 裕二、武川 睦寛
    • Organizer
      G2 plus Retreat
    • Related Report
      2022 Annual Research Report
  • [Presentation] Physiological significance of cytoplasmic retention of SAPKK at high-density conditions2022

    • Author(s)
      三上 夏実、渡海 紀子、森泉 寿士、武川 睦寛
    • Organizer
      G2 plus Retreat
    • Related Report
      2022 Annual Research Report
  • [Presentation] 環境ストレスに応答する細胞内情報伝達機構の解明2022

    • Author(s)
      福田 峻介、久保田 裕二、武川 睦寛
    • Organizer
      G2 plus Retreat
    • Related Report
      2022 Annual Research Report
  • [Presentation] 数理解析を活用したストレス応答シグナル伝達機構の解明2021

    • Author(s)
      武川睦寛
    • Organizer
      網羅的蛋白質合成システムと数理科学が拓く細胞内シグナル経路解明の新展開
    • Related Report
      2021 Research-status Report
    • Invited
  • [Presentation] Formation of stress granules regulates cell fate decisions under stress conditions2021

    • Author(s)
      Mutsuhiro Takekawa
    • Organizer
      第94回日本生化学会大会 シンポジウム
    • Related Report
      2021 Research-status Report
    • Invited
  • [Presentation] Regulation of cellular stress responses by stress granule formation2021

    • Author(s)
      Mutsuhiro Takekawa
    • Organizer
      第44回 日本分子生物学会年会 シンポジウム
    • Related Report
      2021 Research-status Report
    • Invited
  • [Presentation] Regulation of genotoxic stress-induced apoptosis by signaling crosstalk between NF-kB and SAPK pathways2021

    • Author(s)
      Yukari Shiozaki, Yuji Kubota and Mutsuhiro Takekawa
    • Organizer
      48th IMSUT Founding Commemorative Symposium
    • Related Report
      2021 Research-status Report
  • [Presentation] 細胞の生き死にを決定するアナログ-デジタル変換システムの解明2021

    • Author(s)
      森泉寿士、中村貴紀、曺永旻、河西通、武田洋幸、鈴木貴、武川睦寛
    • Organizer
      第73回日本細胞生物学会大会
    • Related Report
      2021 Research-status Report
  • [Presentation] ERK誘導性の発癌を阻害する新規癌抑制因子の同定2021

    • Author(s)
      髙木祐輔、久保田裕二、武川睦寛
    • Organizer
      2021年度AdAMS若手支援技術講習会
    • Related Report
      2021 Research-status Report
  • [Presentation] 数理解析手法を駆使した「中心体複製開始機構とその破綻によって惹起される発癌機構」の解明2021

    • Author(s)
      中村 貴紀, 渡海 紀子, 中澤 崇, 森 竜樹, 鈴木 貴, 武川 睦寛
    • Organizer
      第80回 日本癌学会学術総会
    • Related Report
      2021 Research-status Report
  • [Presentation] Elucidation of the activation and drug-resistance mechanisms of diseases-associated MEK1 mutants2021

    • Author(s)
      Yuji Kubota, Yuko Fujioka, Nobuo N. Noda, and Mutsuhiro Takekawa
    • Organizer
      第80回日本癌学会学術総会
    • Related Report
      2021 Research-status Report
  • [Presentation] ERK誘導性の発癌を阻害する新規癌抑制遺伝子の同定2021

    • Author(s)
      Yusuke Takagi, Yuji Kubota, Hirotaka Takahashi, Tatsuya Sawasaki, Hidetaka Kosako, Mutsuhiro Takekawa
    • Organizer
      第80回日本癌学会学術総会
    • Related Report
      2021 Research-status Report
  • [Presentation] SAPKにより制御されているmiRNA-Xは大腸癌のアポトーシスを抑制する2021

    • Author(s)
      渡海 紀子, 中村 貴紀, 武川 睦寛
    • Organizer
      第80回 日本癌学会学術総会
    • Related Report
      2021 Research-status Report
  • [Presentation] Mutual regulation between MAPK phosphatases and the ERK pathway2021

    • Author(s)
      Mariko Saitoh, Yuji Kubota, Mutsuhiro Takekawa
    • Organizer
      G2 plus retreat
    • Related Report
      2021 Research-status Report
  • [Presentation] DNA損傷ストレスにより活性化するシグナル伝達経路と細胞運命決定機構の解析2021

    • Author(s)
      久保田裕二、塩崎ゆかり、武川睦寛
    • Organizer
      第15回日本臨床ストレス応答学会大会
    • Related Report
      2021 Research-status Report
  • [Presentation] DNA損傷ストレスに応答する細胞内シグナル伝達機構の解析2021

    • Author(s)
      塩崎ゆかり、久保田裕二、武川睦寛
    • Organizer
      CREST多細胞第三回領域会議
    • Related Report
      2021 Research-status Report
  • [Presentation] Identification of a novel tumor suppressive gene that prevents ERK-induced tumorigenesis2021

    • Author(s)
      Yusuke Takagi, Yuji Kubota, Mutsuhiro Takekawa
    • Organizer
      CREST多細胞領域 第11回 Rising Star Webinar
    • Related Report
      2021 Research-status Report
  • [Presentation] Phos-tag 電気泳動法を活用したMAPK phosphatase (MKP) とMAPK経路の相互調節機構の解明2021

    • Author(s)
      齊藤 まりこ、久保田 裕二、武川 睦寛
    • Organizer
      第72回日本電気泳動学会
    • Related Report
      2021 Research-status Report
  • [Presentation] APEX2を用いた近位ビオチン標識法と質量分析を活用した熱刺激誘導性液-液相分離顆粒コアタンパク質の探索2021

    • Author(s)
      松田 碧, 中村 貴紀, 小迫 英尊, 武川 睦寛
    • Organizer
      第72回日本電気泳動学会年会
    • Related Report
      2021 Research-status Report
  • [Presentation] Analysis of DNA damage-induced activation of the SAPK signaling pathways2021

    • Author(s)
      塩崎ゆかり、久保田裕二、武川睦寛
    • Organizer
      第80回日本癌学会学術総会
    • Related Report
      2021 Research-status Report
  • [Presentation] Elucidation of the molecular mechanism and physiological function of the SAPK activation induced by oncogenic ERK signaling2021

    • Author(s)
      Saeko Kawataki, Yuji Kubota, Mutsuhiro Takekawa
    • Organizer
      G2 plus Retreat
    • Related Report
      2021 Research-status Report
  • [Presentation] Identification of viral RNA sensor proteins as novel components of stress granules2021

    • Author(s)
      Daisuke Yoshioka, Takanori Nakamura, Mutsuhiro Takekawa
    • Organizer
      G2 plus Retreat
    • Related Report
      2021 Research-status Report
  • [Presentation] Analysis of novel carcinogenic mechanisms driven by K-RAS mutation2021

    • Author(s)
      梨本 淳一郎、久保田 裕二、武川 睦寛
    • Organizer
      G2 plus Retreat
    • Related Report
      2021 Research-status Report
  • [Presentation] Functional analysis of a mitochondrial protein whose expression is suppressed by activation of the ERK pathway2021

    • Author(s)
      Ayaka Sakurai, Yusuke Takagi, Yuji Kubota, Mutsuhiro Takekawa
    • Organizer
      G2 plus Retreat
    • Related Report
      2021 Research-status Report
  • [Presentation] Analysis of the expression mechanism and molecular function of oncogenic ERK-inducible tetraspanin proteins in cancer2021

    • Author(s)
      Shiho Sameshima, Yuji Kubota, Mutsuhiro Takekawa
    • Organizer
      G2 plus Retreat
    • Related Report
      2021 Research-status Report
  • [Presentation] Identification of a novel core protein essential for stress granule formation under heat shock conditions2021

    • Author(s)
      Aoi Matsuda, Takanori Nakamura, Mutsuhiro Takekawa
    • Organizer
      G2 plus Retreat
    • Related Report
      2021 Research-status Report
  • [Presentation] 発癌ストレスによって誘導されるSAPK経路活性化の分子機構と生理的意義の解析2021

    • Author(s)
      川瀧 紗英子, 久保田 裕二, 武川 睦寛
    • Organizer
      第44回 日本分子生物学会年会
    • Related Report
      2021 Research-status Report
  • [Presentation] ERK活性依存的に発現抑制されるミトコンドリア局在タンパク質の解析2021

    • Author(s)
      櫻井 文香, 高木 祐輔, 久保田 裕二, 武川 睦寛
    • Organizer
      第44回 日本分子生物学会年会
    • Related Report
      2021 Research-status Report
  • [Presentation] 熱ショック誘導性ストレス顆粒形成を担う新規コアタンパク質の同定2021

    • Author(s)
      松田 碧, 中村 貴紀, 小迫 英尊, 武川 睦寛
    • Organizer
      第44回日本分子生物学会年会
    • Related Report
      2021 Research-status Report
  • [Presentation] Regulation of stress-induced apoptotic cell death by stress granule formation2021

    • Author(s)
      Mutsuhiro Takekawa
    • Organizer
      OIST seminar
    • Related Report
      2020 Research-status Report
    • Invited
  • [Presentation] Spatio-temporal dynamics of SAPKK regulates cell fate decisions under stress conditions2020

    • Author(s)
      Mutsuhiro Takekawa
    • Organizer
      Fusion of Mathematics and Biology
    • Related Report
      2020 Research-status Report
    • Int'l Joint Research / Invited
  • [Presentation] Mathematical modeling of the recruitment of centriole biogenesis regulators to mother centrioles in the S-phase2020

    • Author(s)
      Takanori Nakamura, Noriko Nishizumi-Tokai, Takashi Nakazawa, Tatsuki Mori, Takashi Suzuki, Mutsuhiro Takekawa
    • Organizer
      Fusion of Mathematics and Biology
    • Related Report
      2020 Research-status Report
    • Int'l Joint Research / Invited
  • [Presentation] ERKシグナル誘導遺伝子による細胞機能制御と発癌2020

    • Author(s)
      武川睦寛
    • Organizer
      第93回日本生化学会大会シンポジウム
    • Related Report
      2020 Research-status Report
    • Invited
  • [Presentation] 新規酸化ストレスセンサー分子によるp38/JNKシグナルとサイトカイン産生の制御2020

    • Author(s)
      武川睦寛
    • Organizer
      MBSJ2020、第43回日本分子生物学会年会ワークショップ
    • Related Report
      2020 Research-status Report
    • Invited
  • [Presentation] 数理解析に基づくMAPKシグナルと生命機能制御機構の解明2020

    • Author(s)
      武川睦寛
    • Organizer
      令和2年度新学術領域研究数理シグナル領域推進会議
    • Related Report
      2020 Research-status Report
  • [Presentation] DNA損傷に応答するSAPKシグナル伝達機構の解析2020

    • Author(s)
      塩崎ゆかり、久保田裕二、武川睦寛
    • Organizer
      第79回日本癌学会学術総会
    • Related Report
      2020 Research-status Report
  • [Presentation] カスパーゼ依存的蛋白質切断によるERKシグナル抑制機構2020

    • Author(s)
      久保田裕二、武川睦寛
    • Organizer
      第79回日本癌学会学術総会
    • Related Report
      2020 Research-status Report
  • [Presentation] 癌遺伝子によるストレス応答シグナル伝達経路の活性化機構の解析2020

    • Author(s)
      川瀧紗英子、久保田裕二、武川睦寛
    • Organizer
      第20回東京大学生命科学シンポジウム
    • Related Report
      2020 Research-status Report
  • [Presentation] カスパーゼ依存的な蛋白質切断を介したERKシグナルの新規活性制御機構2020

    • Author(s)
      久保田裕二、武川睦寛
    • Organizer
      第71回日本電気泳動学会総会
    • Related Report
      2020 Research-status Report
  • [Presentation] ERK経路の異常活性化により発現誘導される新規遺伝子の同定および機能解析2020

    • Author(s)
      高木祐輔、久保田裕二、武川睦寛
    • Organizer
      第71回日本電気泳動学会総会
    • Related Report
      2020 Research-status Report
  • [Presentation] 発癌シグナルによる p38/JNK 経路活性化の分子機構の解明2020

    • Author(s)
      川瀧紗英子、久保田裕二、武川睦寛
    • Organizer
      第71回日本電気泳動学会総会
    • Related Report
      2020 Research-status Report
  • [Presentation] ストレス顆粒の新規構成因子およびその生理機能の解析2020

    • Author(s)
      吉岡 大介、中村 貴紀、武川 睦寛
    • Organizer
      第43回日本分子生物学会年会
    • Related Report
      2020 Research-status Report
  • [Presentation] Elucidation of the molecular mechanism underlying oncogene-induced activation of the p38 and JNK pathways.2020

    • Author(s)
      Saeko Kawataki, Yuji Kubota, Mutsuhiro Takekawa
    • Organizer
      G2 plus Retreat
    • Related Report
      2020 Research-status Report
  • [Presentation] Regulation of stress-activated p38/JNK MAPK signaling pathways under oxidative stress conditions.2019

    • Author(s)
      Mutsuhiro Takekawa
    • Organizer
      Cold Spring Harbor Asia Conference “Kinase and Phosphatase Signaling”
    • Related Report
      2019 Research-status Report
    • Int'l Joint Research / Invited
  • [Presentation] Spatio-temporal regulation of stress-activated MAPK signaling and its role in cytokine production.2019

    • Author(s)
      Mutsuhiro Takekawa
    • Organizer
      Symposium for “Interface between Immunology & Quantitative Biology”
    • Related Report
      2019 Research-status Report
    • Int'l Joint Research / Invited
  • [Presentation] 数理科学を活用したJNKシグナルと細胞運命制御機構の解明2019

    • Author(s)
      武川睦寛
    • Organizer
      第92回日本生化学会大会シンポジウム
    • Related Report
      2019 Research-status Report
    • Invited
  • [Presentation] 新規ストレス・センサーによるストレス応答シグナルと炎症性サイトカイン産生の制御2019

    • Author(s)
      武川睦寛
    • Organizer
      第14回日本臨床ストレス応答学会シンポジウム
    • Related Report
      2019 Research-status Report
    • Invited
  • [Presentation] ストレス顆粒形成によるストレス誘導神経細胞死の制御と活性酸素によるその破綻2019

    • Author(s)
      武川睦寛
    • Organizer
      第38 回日本認知症学会学術集会シンポジウム
    • Related Report
      2019 Research-status Report
    • Invited
  • [Presentation] Regulation of stress-induced apoptotic cell death by stress granule formation2019

    • Author(s)
      Mutsuhiro Takekawa
    • Organizer
      第42回日本分子生物学会年会ワークショップ
    • Related Report
      2019 Research-status Report
    • Invited
  • [Presentation] レクチンアフィニティーゲル電気泳動法を利用したO-GlcNAc化タンパク質の解析2019

    • Author(s)
      久保田 裕二、武川 睦寛
    • Organizer
      本プロテオーム学会2019年大会/第70日本電気泳動学会総会・合同大会シンポジウム
    • Related Report
      2019 Research-status Report
    • Invited
  • [Presentation] 数理解析を活用した中心体複製開始を制御する分子機構の解明2019

    • Author(s)
      中村 貴紀、渡海 紀子、中澤 嵩、森 竜樹、鈴木 貴、武川 睦寛
    • Organizer
      第78回日本癌学会総会
    • Related Report
      2019 Research-status Report
  • [Presentation] 中心体複製初期に起こるPLK4の中心体輸送機構2019

    • Author(s)
      中村 貴紀、西住(渡海) 紀子、中澤 嵩、森 竜樹、鈴木 貴、武川 睦寛
    • Organizer
      第19回日本蛋白質科学年会・第71回日本細胞生物学会 合同年次大会
    • Related Report
      2019 Research-status Report
  • [Presentation] O-GlcNAc化蛋白質の網羅的探索技術の開発と細胞内シグナル伝達解析への応用2019

    • Author(s)
      久保田 裕二、武川 睦寛
    • Organizer
      新学術領域研究「数理シグナル」第3回若手ワークショップ
    • Related Report
      2019 Research-status Report
  • [Presentation] ERK経路の異常活性化により発現誘導される新規遺伝子の同定および機能解析2019

    • Author(s)
      高木 祐輔、久保田 裕二、高橋 宏隆、澤崎 達也、武川 睦寛
    • Organizer
      新学術領域研究「数理シグナル」 第3回若手ワークショップ
    • Related Report
      2019 Research-status Report
  • [Presentation] ストレス顆粒形成を制御する分子機構の解析2019

    • Author(s)
      橋本 夏葉、中村 貴紀、武川 睦寛
    • Organizer
      第42回日本分子生物学会年会
    • Related Report
      2019 Research-status Report
  • [Presentation] ERK経路とストレス応答MAPK経路のクロストーク機構の解明2019

    • Author(s)
      川瀧 紗英子、久保田 裕二、武川 睦寛
    • Organizer
      第42回日本分子生物学会年会
    • Related Report
      2019 Research-status Report
  • [Presentation] DNA損傷によるストレス応答MAPK経路活性化機構の解析2019

    • Author(s)
      塩崎 ゆかり、久保田 裕二、武川 睦寛
    • Organizer
      第42回日本分子生物学会年会
    • Related Report
      2019 Research-status Report
  • [Presentation] ERK経路の異常活性化により発現誘導される新規遺伝子の同定および機能解析2019

    • Author(s)
      高木 祐輔、久保田 裕二、高橋 宏隆、澤崎 達也、武川 睦寛
    • Organizer
      第42回日本分子生物学会年会
    • Related Report
      2019 Research-status Report
  • [Presentation] ストレス応答MAPキナーゼによるmiRNAの発現調節とアポトーシス誘導機構の解明2019

    • Author(s)
      渡海 紀子、中村 貴紀、武川 睦寛
    • Organizer
      第78回日本癌学会総会
    • Related Report
      2019 Research-status Report
  • [Presentation] タンパク質O-GlcNAc化異常による増殖シグナルの活性化2019

    • Author(s)
      久保田 裕二、藤岡 興、武川 睦寛
    • Organizer
      第78回日本癌学会総会
    • Related Report
      2019 Research-status Report
  • [Presentation] Elucidation of the regulatory mechanism for transcription elongation by a novel ERK substrate2019

    • Author(s)
      大江 星菜、久保田 裕二、武川 睦寛
    • Organizer
      第92回日本生化学会大会
    • Related Report
      2019 Research-status Report
  • [Presentation] ERK経路の異常活性化により発現誘導される新規遺伝子の同定および機能解析2019

    • Author(s)
      高木 祐輔、久保田 裕二、武川 睦寛
    • Organizer
      新学術領域研究「数理シグナル」 領域推進会議
    • Related Report
      2019 Research-status Report
  • [Presentation] Warburg効果による糖鎖修飾異常と癌増殖シグナルの活性化2019

    • Author(s)
      久保田 裕二、藤岡 興、武川 睦寛
    • Organizer
      第56回日本臨床分子医学会学術集会
    • Related Report
      2019 Research-status Report
  • [Presentation] Oncogenic activation of the ERK pathway alters the expression profiles of exosomal microRNAs in cancer cells.2019

    • Author(s)
      Shiho Hirose, Yuji Kubota, Mutsuhiro Takekawa
    • Organizer
      第19回東京大学生命科学シンポジウム
    • Related Report
      2019 Research-status Report
  • [Presentation] Spatio-temporal regulation of JNK signaling during cell fate decisions.2019

    • Author(s)
      Takekawa M
    • Organizer
      1st International symposium on Interdisciplinary Approaches to Integrative Understanding of Biological Signaling Networks.
    • Related Report
      2018 Research-status Report
    • Int'l Joint Research / Invited
  • [Presentation] Spatio-temporal dynamics of SAPKK regulates cell fate decisions under stress conditions2019

    • Author(s)
      Takekawa M
    • Organizer
      OIST seminar
    • Related Report
      2018 Research-status Report
    • Invited
  • [Presentation] Mathematical modeling of the recruitment of centriole biogenesis regulators to mother centrioles in centriole duplication phase2019

    • Author(s)
      Nakamura T, Nishizumi-Tokai N, Nakazawa T, Mori T, Suzuki T and Takekawa M.
    • Organizer
      Core-to-core meeting
    • Related Report
      2018 Research-status Report
    • Int'l Joint Research
  • [Presentation] Mathematical analysis of the spatio-temporal regulation of SAPK pathway2019

    • Author(s)
      Moriizumi H, Nakamura T, Youngmin C, Suzuki T and Takekawa M.
    • Organizer
      Core-to-core meeting
    • Related Report
      2018 Research-status Report
    • Int'l Joint Research
  • [Presentation] Quantitative gene expression analysis in cells that express cancer- or congential Ras/MAPK syndrome-derived MEK mutants.2019

    • Author(s)
      Kubota Y, Takagi Y and Takekawa M
    • Organizer
      1st International symposium on Interdisciplinary Approaches to Integrative Understanding of Biological Signaling Networks.
    • Related Report
      2018 Research-status Report
    • Int'l Joint Research
  • [Presentation] The molecular mechanism that recruits centriole biogenesis regulators to mother centrioles in centriole duplication phase.2019

    • Author(s)
      Nakamura T, Nishizumi-Tokai N, Nakazawa T, Mori T, Suzuki T and Takekawa M
    • Organizer
      1st International symposium on Interdisciplinary Approaches to Integrative Understanding of Biological Signaling Networks.
    • Related Report
      2018 Research-status Report
    • Int'l Joint Research
  • [Presentation] 数理解析を活用したSAPKシグナル時空間制御機構の解明2019

    • Author(s)
      森泉 寿士、中村 貴紀、曺 永旻、鈴木 貴、武川 睦寛
    • Organizer
      応用数理学会2019年研究部会連合発表会
    • Related Report
      2018 Research-status Report
  • [Presentation] Regulation of cell-fate decisions by stress-responsive p38/JNK MAPK signaling pathways2018

    • Author(s)
      Takekawa M
    • Organizer
      OIST seminar
    • Related Report
      2018 Research-status Report
    • Invited
  • [Presentation] 新規ストレス・センサーによるストレス応答MAPKシグナルとサイトカイン産生の制御2018

    • Author(s)
      武川 睦寛
    • Organizer
      第91回日本生化学会シンポジウム
    • Related Report
      2018 Research-status Report
    • Invited
  • [Presentation] 数理解析を用いた中心体複製の開始制御機構の解明2018

    • Author(s)
      中村 貴紀、西住 紀子、中澤 嵩、森 竜樹、鈴木 貴、武川 睦寛
    • Organizer
      日本応用数理学会
    • Related Report
      2018 Research-status Report
    • Invited
  • [Presentation] O-GlcNAc化蛋白質の検出と定量解析を可能にするレクチン親和性ゲル電気泳動法の開発と応用2018

    • Author(s)
      久保田 裕二、藤岡 興、武川 睦寛
    • Organizer
      第69回日本電気泳動学会総会シンポジウム
    • Related Report
      2018 Research-status Report
    • Invited
  • [Presentation] 数理解析を活用したSAPKシグナル時空間制御機構の解明2018

    • Author(s)
      森泉 寿士、中村 貴紀、曺 永旻、鈴木 貴、武川 睦寛
    • Organizer
      新学術領域「数理シグナル」第2回若手ワークショップ
    • Related Report
      2018 Research-status Report
  • [Presentation] 数理解析を用いた中心体複製の開始制御機構の解明2018

    • Author(s)
      中村 貴紀、西住 紀子、中澤 嵩、森 竜樹、鈴木 貴、武川 睦寛
    • Organizer
      新学術領域「数理シグナル」第2回若手ワークショップ
    • Related Report
      2018 Research-status Report
  • [Presentation] Identification of exosomal microRNAs induced by oncogenic activation of the ERK pathway2018

    • Author(s)
      Shiho Hirose、Yuji Kubota, Zhang Yao-zhong, Seiya Imoto, Mutsuhiro Takekawa
    • Organizer
      G2 plusリトリート
    • Related Report
      2018 Research-status Report
  • [Presentation] Formation of stress granules suppresses apoptosis by sequestering proapoptotic proteins2018

    • Author(s)
      Daichi Fujikawa、Takanori Nakamura, Mutsuhiro Takekawa
    • Organizer
      G2 plusリトリート
    • Related Report
      2018 Research-status Report
  • [Presentation] Oncogenic activation of the ERK pathway alters miRNA expression profiles in exosomes2018

    • Author(s)
      Shiho Hirose, Yuji Kubota, Zhang Yao-zhong, Seiya Imoto, Mutsuhiro Takekawa
    • Organizer
      東京大学医科学研究所 研究成果発表会
    • Related Report
      2018 Research-status Report
  • [Presentation] Formation of stress granules suppresses apoptosis by sequestering proapoptotic proteins2018

    • Author(s)
      Daichi Fujikawa, Takanori Nakamura, Mutsuhiro Takekawa
    • Organizer
      東京大学医科学研究所 研究成果発表会
    • Related Report
      2018 Research-status Report
  • [Presentation] 数理解析を活用したSAPKシグナル時空間制御機構の解明2018

    • Author(s)
      森泉 寿士、中村 貴紀、武川 睦寛
    • Organizer
      第18回東京大学 生命科学シンポジウム
    • Related Report
      2018 Research-status Report
  • [Presentation] O-GlcNAc化蛋白質の検出と定量解析を可能にするレクチン親和性ゲル電気泳動法の開発と応用2018

    • Author(s)
      久保田 裕二、藤岡 興、武川 睦寛
    • Organizer
      第91回日本生化学会大会
    • Related Report
      2018 Research-status Report
  • [Presentation] ストレス応答MAPキナーゼp38, JNKによるアポトーシス関連miRNAの発現抑制2018

    • Author(s)
      渡海 紀子、中村 貴紀、武川 睦寛
    • Organizer
      第77回日本癌学会学術総会
    • Related Report
      2018 Research-status Report
  • [Presentation] 癌および先天性Ras/MAPK症候群で見出されるMEK突然変異体の解析2018

    • Author(s)
      久保田 裕二、高木 祐輔、松原 大祐、Ashwini Patil、木下 英司、中井 謙太、武川 睦寛
    • Organizer
      第77回日本癌学会学術総会
    • Related Report
      2018 Research-status Report
  • [Presentation] ERK経路の異常活性化により発現誘導される遺伝子の同定と機能解析2018

    • Author(s)
      高木 祐輔、久保田 裕二、武川 睦寛
    • Organizer
      第77回日本癌学会学術総会
    • Related Report
      2018 Research-status Report
  • [Presentation] ERK経路の異常活性化に伴いエクソソームに蓄積するmiRNAの解析、および早期がん診断マーカーへの応用2018

    • Author(s)
      広瀬 思帆、久保田 裕二、武川 睦寛
    • Organizer
      第77回日本癌学会学術総会
    • Related Report
      2018 Research-status Report
  • [Presentation] 数理解析を活用したSAPKシグナル時空間制御機構の解明2018

    • Author(s)
      森泉 寿士、中村 貴紀、曺 永旻、鈴木 貴、武川 睦寛
    • Organizer
      第41回日本分子生物学会年会
    • Related Report
      2018 Research-status Report
  • [Presentation] ERK新規基質分子による転写伸長反応制御機構の解明2018

    • Author(s)
      大江 星菜、久保田 裕二、武川 睦寛
    • Organizer
      第41回日本分子生物学会年会
    • Related Report
      2018 Research-status Report
  • [Presentation] ERK経路の異常活性化により発現が亢進する新規遺伝子の同定と機能解析2018

    • Author(s)
      高木 祐輔、久保田 裕二、高橋 宏隆、澤崎 達也、武川 睦寛
    • Organizer
      第41回日本分子生物学会年会
    • Related Report
      2018 Research-status Report
  • [Presentation] ストレス応答MAPキナーゼによるアポトーシス抑制性miRNAの発現制御2018

    • Author(s)
      渡海 紀子、中村 貴紀、武川 睦寛
    • Organizer
      第41回日本分子生物学会年会
    • Related Report
      2018 Research-status Report
  • [Presentation] 数理解析を駆使した中心体複製開始を制御する分子機構の解明2018

    • Author(s)
      中村 貴紀、西住 紀子、中澤 嵩、森 竜樹、鈴木 貴、武川 睦寛
    • Organizer
      第41回日本分子生物学会年会
    • Related Report
      2018 Research-status Report
  • [Presentation] ストレス顆粒形成によるアポトーシス抑制機構の解明2018

    • Author(s)
      藤川 大地、中村 貴紀、武川 睦寛
    • Organizer
      第41回日本分子生物学会年会
    • Related Report
      2018 Research-status Report
  • [Presentation] ERK経路の活性化依存的にエクソソームに蓄積する癌関連miRNAの網羅的探2018

    • Author(s)
      広瀬 思帆、久保田 裕二、武川 睦寛
    • Organizer
      第41回日本分子生物学会年会
    • Related Report
      2018 Research-status Report
  • [Presentation] 炎症性サイトカインによるMTK1活性化機構の解析2018

    • Author(s)
      小森 満美子、久保田 裕二、武川 睦寛
    • Organizer
      第41回日本分子生物学会年会
    • Related Report
      2018 Research-status Report
  • [Presentation] ストレス顆粒を構成する新規因子の同定とその機能解析2018

    • Author(s)
      田口 真梨、中村 貴紀、武川 睦寛
    • Organizer
      第41回日本分子生物学会年会
    • Related Report
      2018 Research-status Report
  • [Presentation] ERK経路の異常活性化により誘発される新規癌増殖シグナル機構の解明2018

    • Author(s)
      久保田 裕二、武川 睦寛
    • Organizer
      第41回日本分子生物学会年会
    • Related Report
      2018 Research-status Report
  • [Presentation] 数理解析を活用した中心体複製制御機構の解明2018

    • Author(s)
      武川睦寛
    • Organizer
      第1回MMDS/IMSUT/CBM合同ワークショップ
    • Related Report
      2017 Research-status Report
    • Invited
  • [Presentation] ERKシグナルによる癌抑制遺伝子のエピゲノム・サイレンシングと発がん2018

    • Author(s)
      武川睦寛
    • Organizer
      東京生化学研究会2017年度研究報告会
    • Related Report
      2017 Research-status Report
    • Invited
  • [Presentation] 癌抑制遺伝子MKK4のフィードバック・リン酸化の機能解析2018

    • Author(s)
      森泉寿士, 中村貴紀, 武川睦寛
    • Organizer
      第1回MMDS、医科学研究所、新領域創成科学研究科合同ワークショップ
    • Related Report
      2017 Research-status Report
  • [Presentation] フィードバック・リン酸化によるERKシグナル制御機構の数理シミュレーション解析2018

    • Author(s)
      久保田裕二、武川睦寛
    • Organizer
      第1回MMDS、医科学研究所、新領域創成科学研究科合同ワークショップ
    • Related Report
      2017 Research-status Report
  • [Presentation] 癌抑制遺伝子MKK4のフィードバック・リン酸化の機能解析2018

    • Author(s)
      森泉寿士, 中村貴紀, 武川睦寛
    • Organizer
      新学術領域 数理シグナル 第二回 公開シンポジウム
    • Related Report
      2017 Research-status Report
  • [Presentation] Aberrant post-translational modifications of the MEK MAPKK in cancer.2017

    • Author(s)
      Mutsuhiro Takekawa
    • Organizer
      OIST seminar
    • Place of Presentation
      OIST(沖縄)
    • Year and Date
      2017-02-22
    • Related Report
      2016 Research-status Report
    • Int'l Joint Research / Invited
  • [Presentation] MAPKシグナルおよびストレス顆粒形成による細胞機能の制御と疾患2017

    • Author(s)
      武川睦寛
    • Organizer
      新学術領域「数理シグナル」第一回公開シンポジウム「数理シグナル」学術領域の創出
    • Place of Presentation
      東京大学(東京)
    • Year and Date
      2017-02-11
    • Related Report
      2016 Research-status Report
    • Invited
  • [Presentation] Aberrant regulation of MAPK signaling pathways in cancer.2017

    • Author(s)
      Takekawa M
    • Organizer
      The 48th international symposium of the Princess Takamatsu cancer research fund
    • Related Report
      2017 Research-status Report
    • Int'l Joint Research / Invited
  • [Presentation] 数理科学を活用した生命・医科学研究2017

    • Author(s)
      武川睦寛
    • Organizer
      数学教育学会2017夏季研究会
    • Related Report
      2017 Research-status Report
    • Invited
  • [Presentation] 数理解析を活用した中心体複製制御機構の解明2017

    • Author(s)
      武川睦寛
    • Organizer
      2017年度生命科学系学会合同年次大会(ConBio2017)ワークショップ
    • Related Report
      2017 Research-status Report
    • Invited
  • [Presentation] A novel method for the detection of O-GlcNAc-modified proteins: WGA-based lectin affinity gel electrophoresis (WGA-SDS-PAGE)2017

    • Author(s)
      Yuji Kubota, Ko Fujioka and Mutsuhiro Takekawa
    • Organizer
      プロテイン・アイランド松山
    • Related Report
      2017 Research-status Report
    • Int'l Joint Research
  • [Presentation] Comprehensive analysis of stress granule components2017

    • Author(s)
      Daichi Fujikawa, Takanori Nakamura and Mutsuhiro Takekawa
    • Organizer
      CIMR(Cambridge Institute for Medical Research)-University of Tokyo Symposium 2017
    • Related Report
      2017 Research-status Report
    • Int'l Joint Research
  • [Presentation] Comprehensive analysis of stress granule components2017

    • Author(s)
      Daichi Fujikawa, Takanori Nakamura and Mutsuhiro Takekawa
    • Organizer
      Dundee-Tokyo Symposium 2017
    • Related Report
      2017 Research-status Report
    • Int'l Joint Research
  • [Presentation] Functional analysis of feedback-phosphorylation of MKK4 by MAPKs2017

    • Author(s)
      Hisashi Moriizumi, Takanori Nakamura and Mutsuhiro Takekawa
    • Organizer
      AACR Annual Meeting 2017
    • Related Report
      2017 Research-status Report
    • Int'l Joint Research
  • [Presentation] The molecular mechanisms that maintain the numerical integrity of centrosomes under stress2017

    • Author(s)
      Takanori Nakamura and Mutsuhiro Takekawa
    • Organizer
      EMBO Conference “Centrosomes and Spindle Pole Bodies”
    • Related Report
      2017 Research-status Report
    • Int'l Joint Research
  • [Presentation] Functional analysis of a novel ERK substrate, MCRIP12017

    • Author(s)
      Jane Weng, Takanori Nakamura and Mutsuhiro Takekawa
    • Organizer
      24th East Asia Joint Symposium on Biomedical Research
    • Related Report
      2017 Research-status Report
    • Int'l Joint Research
  • [Presentation] Functional analysis of a novel ERK substrate, MCRIP12017

    • Author(s)
      Jane Weng, Takanori Nakamura and Mutsuhiro Takekawa
    • Organizer
      12th International Symposium of the institute Network
    • Related Report
      2017 Research-status Report
    • Int'l Joint Research
  • [Presentation] 数理解析に基づくMAPKシグナルと生命機能制御機構の解明2017

    • Author(s)
      武川睦寛
    • Organizer
      新学術領域「数理シグナル」領域推進会議
    • Related Report
      2017 Research-status Report
    • Invited
  • [Presentation] 中心体複製開始を司るPLK4中心体局在機構の解明2017

    • Author(s)
      中村貴紀、西住(渡海)紀子、中澤嵩、鈴木貴、武川睦寛
    • Organizer
      2017年度生命科学系学会合同年次大会(ConBio2017)
    • Related Report
      2017 Research-status Report
  • [Presentation] Identification of a novel redox-sensor that mediates delayed activation of stress-responsive MAPKs by oxidative stress2017

    • Author(s)
      Moe Matsushita, Takanori Nakamura and Mutsuhiro Takekawa
    • Organizer
      IMSUT G2リトリート
    • Related Report
      2017 Research-status Report
  • [Presentation] Identification and phosphorylation analysis of a novel MAPK substrate2017

    • Author(s)
      Sae Uchida, Yuji Kubota, Mutsuhiro Takekawa
    • Organizer
      IMSUT G2リトリート
    • Related Report
      2017 Research-status Report
  • [Presentation] ストレス顆粒の形成機構および生理機能の解明2017

    • Author(s)
      藤川大地、中村貴紀、武川睦寛
    • Organizer
      新学術領域研究 数理シグナル 第1回若手ワークショップ
    • Related Report
      2017 Research-status Report
  • [Presentation] 癌抑制遺伝子MKK4のフィードバック・リン酸化の機能解析2017

    • Author(s)
      森泉寿士、中村貴紀、武川睦寛
    • Organizer
      新学術領域研究 数理シグナル 第1回若手ワークショップ
    • Related Report
      2017 Research-status Report
  • [Presentation] 癌および先天性Ras/MAPK 症候群におけるMEK 変異体の異常活性化機構の解明と特異的阻害剤の同定2017

    • Author(s)
      久保田裕二、武川睦寛
    • Organizer
      新学術領域研究 数理シグナル 第1回若手ワークショップ
    • Related Report
      2017 Research-status Report
  • [Presentation] エクソソーム中に蓄積するがん特異的miRNAの同定およびその早期診断マーカーとして2017

    • Author(s)
      広瀬思帆、久保田裕二、武川睦寛
    • Organizer
      GLAFS研究進捗状況報告会
    • Related Report
      2017 Research-status Report
  • [Presentation] 蛋白質O-GlcNAc化によるMAPK経路の新たな制御メカニズムの解明2017

    • Author(s)
      藤岡興、久保田裕二、武川睦寛
    • Organizer
      第54回日本臨床分子医学会学術集会
    • Related Report
      2017 Research-status Report
  • [Presentation] シグナル伝達異常によって発現誘導される長鎖非コードRNAの同定2017

    • Author(s)
      中野雄太、久保田裕二、武川睦寛
    • Organizer
      第54回日本臨床分子医学会学術集会
    • Related Report
      2017 Research-status Report
  • [Presentation] Identification of novel ERK substrates by yeast three hybrid screening2017

    • Author(s)
      Seina Ohe, Yuji Kubota and Mutsuhiro Takekawa
    • Organizer
      東京大学生命科学シンポジウム
    • Related Report
      2017 Research-status Report
  • [Presentation] Functional analysis of feedback-phosphorylation of MKK4 by MAPKs2017

    • Author(s)
      Hisashi Moriizumi, Takanori Nakamura and Mutsuhiro Takekawa
    • Organizer
      第76回日本癌学会学術総会
    • Related Report
      2017 Research-status Report
  • [Presentation] Identification of a novel protein that is induced by hyperactiveation of the ERK pathway2017

    • Author(s)
      Yusuke Takagi, Yuji Kubota and Mutsuhiro Takekawa
    • Organizer
      第76回日本癌学会学術総会
    • Related Report
      2017 Research-status Report
  • [Presentation] Analysis of a novel O-GlcNAc protein involved in the MAPK pathway2017

    • Author(s)
      Ko Fujioka, Yuji Kubota and Mutsuhiro Takekawa
    • Organizer
      第76回日本癌学会学術総会
    • Related Report
      2017 Research-status Report
  • [Presentation] Negative regulation of the ERK pathway by caspase-mediated cleavage of MEK1 during apoptosis.2017

    • Author(s)
      Yuji Kubota, Tomoyuki Tsuchiya and Mutsuhiro Takekawa
    • Organizer
      第76回日本癌学会学術総会
    • Related Report
      2017 Research-status Report
  • [Presentation] ストレス応答キナーゼMTK1による新たなストレス感知・応答機構2017

    • Author(s)
      松下萌恵、中村貴紀、武川睦寛
    • Organizer
      2017年度生命科学系学会合同年次大会(ConBio2017)
    • Related Report
      2017 Research-status Report
  • [Presentation] ERK経路の異常活性化により発現が亢進する新規遺伝子の同定と機能解析2017

    • Author(s)
      高木祐輔、久保田裕二、武川睦寛
    • Organizer
      2017年度生命科学系学会合同年次大会(ConBio2017)
    • Related Report
      2017 Research-status Report
  • [Presentation] ERK経路の異常活性化によって発現誘導される長鎖非コードRNAの同定と機能解析2017

    • Author(s)
      中野雄太、久保田裕二、武川睦寛
    • Organizer
      2017年度生命科学系学会合同年次大会(ConBio2017)
    • Related Report
      2017 Research-status Report
  • [Presentation] 蛋白質O-GlcNAc化を定量的かつ簡便に検出する新たな解析方法の開発2017

    • Author(s)
      久保田裕二、藤岡興、武川睦寛
    • Organizer
      2017年度生命科学系学会合同年次大会(ConBio2017)
    • Related Report
      2017 Research-status Report
  • [Presentation] ストレス応答MAPK経路によって制御されるmiRNAの機能解析2017

    • Author(s)
      渡海紀子、中村貴紀、武川睦寛
    • Organizer
      2017年度生命科学系学会合同年次大会(ConBio2017)
    • Related Report
      2017 Research-status Report
  • [Presentation] 新規ERK基質分子MCRIP1の生理機能解析2017

    • Author(s)
      Jane Weng、中村貴紀、武川睦寛
    • Organizer
      2017年度生命科学系学会合同年次大会(ConBio2017)
    • Related Report
      2017 Research-status Report
  • [Presentation] ストレス顆粒形成によるストレス応答の制御と疾患2016

    • Author(s)
      武川睦寛
    • Organizer
      Science Medical Frontier Forum
    • Place of Presentation
      TKPガーデンシティー品川(東京)
    • Year and Date
      2016-12-08
    • Related Report
      2016 Research-status Report
    • Invited
  • [Presentation] The molecular mechanisms that maintain the numerical integrity of centrosomes2016

    • Author(s)
      Takanori Nakamura and Mutsuhiro Takekawa
    • Organizer
      American Society of Cell Biology (ASCB) annual meeting
    • Place of Presentation
      San Francisco (USA)
    • Year and Date
      2016-12-03
    • Related Report
      2016 Research-status Report
    • Int'l Joint Research
  • [Presentation] フィードバック・リン酸化によるERKシグナルと発癌の制御2016

    • Author(s)
      武川睦寛
    • Organizer
      第39回日本分子生物学会年会シンポジウム
    • Place of Presentation
      パシフィコ横浜(横浜)
    • Year and Date
      2016-11-30
    • Related Report
      2016 Research-status Report
    • Invited
  • [Presentation] ストレス応答MAPK経路依存的に発現調節されるmiRNAの同定2016

    • Author(s)
      西住(渡海)紀子、中村貴紀、武川睦寛
    • Organizer
      第39回日本分子生物学会年会
    • Place of Presentation
      パシフィコ横浜(横浜)
    • Year and Date
      2016-11-30
    • Related Report
      2016 Research-status Report
  • [Presentation] 酵母Three Hybrid法による新規ERK基質分子の同定と生理機能の解明2016

    • Author(s)
      大江星菜, 久保田裕二、武川睦寛
    • Organizer
      第39回日本分子生物学会年会
    • Place of Presentation
      パシフィコ横浜(横浜)
    • Year and Date
      2016-11-30
    • Related Report
      2016 Research-status Report
  • [Presentation] フォスタグ技術とプロテオミクス情報を活用した細胞内MEK1リン酸化ダイナミクスのプロファイリング2016

    • Author(s)
      木下英司、木下恵美子、久保田裕二、武川睦寛、小池透
    • Organizer
      第39回日本分子生物学会年会
    • Place of Presentation
      パシフィコ横浜(横浜)
    • Year and Date
      2016-11-30
    • Related Report
      2016 Research-status Report
  • [Presentation] Comprehensive analysis of stress granule components2016

    • Author(s)
      Zizheng Li and Mutsuhiro Takekawa
    • Organizer
      IMSUT G2 retreat
    • Place of Presentation
      検見川セミナーハウス(千葉)
    • Year and Date
      2016-11-14
    • Related Report
      2016 Research-status Report
  • [Presentation] Identification of ERK-inducible long non-coding RNAs that are highly expressed in cancer2016

    • Author(s)
      Yuta Nakano and Mutshiro Takekawa
    • Organizer
      IMSUT G2 retreat
    • Place of Presentation
      検見川セミナーハウス(千葉)
    • Year and Date
      2016-11-14
    • Related Report
      2016 Research-status Report
  • [Presentation] Dysregulation of cell signaling pathways in cancer2016

    • Author(s)
      武川睦寛
    • Organizer
      第75回日本癌学会学術総会「がん研究入門コース1」
    • Place of Presentation
      パシフィコ横浜(横浜)
    • Year and Date
      2016-10-06
    • Related Report
      2016 Research-status Report
    • Invited
  • [Presentation] Functional analysis of feedback-phosphorylation of MKK4 by MAPKs2016

    • Author(s)
      Moriizumi Hisashi, Takanori Nakamura and Mutsuhiro Takekawa
    • Organizer
      第75回日本癌学会学術総会
    • Place of Presentation
      パシフィコ横浜(横浜)
    • Year and Date
      2016-10-06
    • Related Report
      2016 Research-status Report
  • [Presentation] DUSP4の発現低下は膵上皮内癌から浸潤癌への進展に関与する2016

    • Author(s)
      Naoki Hijiya, Yoshiyuki Tsukamoto, Chisato Nakata, Tomoki Kai, Keiko Matsuura, Masafumi Inomata, Kuniaki Shirao, Hiromu Mori, Masao Seto, Masahiro Aoki, Mutsuhiro Takekawa, Masatsugu Moriyama
    • Organizer
      第75回日本癌学会学術総会
    • Place of Presentation
      パシフィコ横浜(横浜)
    • Year and Date
      2016-10-06
    • Related Report
      2016 Research-status Report
  • [Presentation] MCRIP1, a novel ERK substrate, mediates ERK-induced epigenetic gene silencing during epithelial-to-mesenchymal transition2016

    • Author(s)
      Mutsuhiro Takekawa
    • Organizer
      15th Karolinska Institute Cancer Retreat
    • Place of Presentation
      Stockholm (Sweden)
    • Year and Date
      2016-09-26
    • Related Report
      2016 Research-status Report
    • Int'l Joint Research / Invited
  • [Presentation] Functional analysis of feedback-phosphorylation of MKK4 by MAPKs2016

    • Author(s)
      Moriizumi Hisashi, Takanori Nakamura and Mutsuhito Takekawa
    • Organizer
      IARU International Symposium on Aging, Longevity and Health
    • Place of Presentation
      東京大学(東京)
    • Year and Date
      2016-09-26
    • Related Report
      2016 Research-status Report
    • Int'l Joint Research
  • [Presentation] 膵上皮内癌が浸潤癌へ進展するメカニズムの解明2016

    • Author(s)
      守山正胤、泥谷直樹、塚本善之、柴田浩平、猪股雅史、森宣、白尾國昭、竹内一郎、瀬戸加大、青木正博、武川睦寛
    • Organizer
      第27回日本消化器癌発生学会総会
    • Place of Presentation
      城山観光ホテル(鹿児島)
    • Year and Date
      2016-09-15
    • Related Report
      2016 Research-status Report
  • [Presentation] ストレス顆粒形成によるストレス誘導アポトーシスの制御と活性酸素によるその破綻2016

    • Author(s)
      武川睦寛
    • Organizer
      第67回日本電気泳動学会総会特別講演
    • Place of Presentation
      釧路市観光国際交流センター(釧路)
    • Year and Date
      2016-08-27
    • Related Report
      2016 Research-status Report
    • Invited
  • [Presentation] 数理解析に基づくMAPKシグナルと生命機能制御機構の解明2016

    • Author(s)
      武川睦寛
    • Organizer
      新学術領域「数理シグナル」計画班合同会議
    • Place of Presentation
      東京大学(東京)
    • Year and Date
      2016-08-17
    • Related Report
      2016 Research-status Report
    • Invited
  • [Presentation] Comprehensive analysis of stress granule components2016

    • Author(s)
      李 子政、武川睦寛
    • Organizer
      第9回CBMS発表会
    • Place of Presentation
      東京大学(東京)
    • Year and Date
      2016-07-25
    • Related Report
      2016 Research-status Report
  • [Presentation] Molecular mechanism by which PLK4 is recruited to centrosomes2016

    • Author(s)
      杉崎 麻友、武川睦寛
    • Organizer
      第9回CBMS発表会
    • Place of Presentation
      東京大学(東京)
    • Year and Date
      2016-07-25
    • Related Report
      2016 Research-status Report
  • [Presentation] TIA1 oxidation inhibits stress granule assembly and sensitizes cells to stress-induced apoptosis2016

    • Author(s)
      武川睦寛
    • Organizer
      第一回RNA顆粒/RNAタンパク質複合体研究会
    • Place of Presentation
      岡崎コンファレンスセンター(岡崎)
    • Year and Date
      2016-07-16
    • Related Report
      2016 Research-status Report
    • Invited
  • [Remarks] 数理シグナルwebサイト

    • URL

      http://math-signal.umin.jp/

    • Related Report
      2022 Annual Research Report 2021 Research-status Report
  • [Remarks] 新学術領域研究「数理シグナル」ホームページ

    • URL

      http://math-signal.umin.jp/

    • Related Report
      2020 Research-status Report
  • [Remarks] 新学術領域「数理シグナル」ホームページ

    • URL

      http://math-signal.umin.jp/

    • Related Report
      2019 Research-status Report 2018 Research-status Report
  • [Remarks] http://math-signal.umin.jp/index.html

    • Related Report
      2017 Research-status Report
  • [Remarks] 新学術領域研究「数理シグナル」領域ホームページ

    • URL

      http://math-signal.umin.jp/

    • Related Report
      2016 Research-status Report
  • [Funded Workshop] Fusion of Mathematics and Biology2020

    • Related Report
      2020 Research-status Report
  • [Funded Workshop] 1st International symposium on Interdisciplinary Approaches to Integrative Understanding of Biological Signaling Networks.2019

    • Related Report
      2018 Research-status Report
  • [Funded Workshop] CAS-IMSUT Workshop on Infectious Diseases2017

    • Related Report
      2017 Research-status Report

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Published: 2016-07-04   Modified: 2024-01-30  

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