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Middle molecular strategy: Creation of higher bio-functional molecules by integrated synthesis

Administrative Group

Project AreaMiddle molecular strategy: Creation of higher bio-functional molecules by integrated synthesis.
Project/Area Number 15H05835
Research Category

Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)

Allocation TypeSingle-year Grants
Review Section Science and Engineering
Research InstitutionOsaka University

Principal Investigator

Fukase Koichi  大阪大学, 理学研究科, 教授 (80192722)

Co-Investigator(Kenkyū-buntansha) 安田 誠  大阪大学, 工学研究科, 教授 (40273601)
中田 雅久  早稲田大学, 理工学術院, 教授 (50198131)
松原 誠二郎  京都大学, 工学研究科, 教授 (90190496)
土井 隆行  東北大学, 薬学研究科, 教授 (90212076)
Project Period (FY) 2015-06-29 – 2020-03-31
Project Status Completed (Fiscal Year 2019)
Budget Amount *help
¥202,150,000 (Direct Cost: ¥155,500,000、Indirect Cost: ¥46,650,000)
Fiscal Year 2019: ¥18,460,000 (Direct Cost: ¥14,200,000、Indirect Cost: ¥4,260,000)
Fiscal Year 2018: ¥18,590,000 (Direct Cost: ¥14,300,000、Indirect Cost: ¥4,290,000)
Fiscal Year 2017: ¥18,590,000 (Direct Cost: ¥14,300,000、Indirect Cost: ¥4,290,000)
Fiscal Year 2016: ¥18,590,000 (Direct Cost: ¥14,300,000、Indirect Cost: ¥4,290,000)
Fiscal Year 2015: ¥127,920,000 (Direct Cost: ¥98,400,000、Indirect Cost: ¥29,520,000)
Keywords中分子 / 反応集積 / 生物機能制御 / 反応集積化 / 機能集積 / 複合化 / マイクロフロー
Outline of Final Research Achievements

The purpose of this study was to development of efficient synthetic method and creation of highly functional middle molecule. For this purpose, we improved synthetic process using "reaction integration". In this project, we organized 9 symposium, 5 international symposium, and 7 symposium for young researchers for promoting the development of this field through active exchange of information among researchers. We also co-organized many international symposiums. In addition, we actively provided information to the media and conducted outreach activities. We strongly promoted collaborations.

Academic Significance and Societal Importance of the Research Achievements

近年、中分子領域の化合物が、高次生物機能分子として注目を集めている。しかし、生物活性天然物など、中分子の多くは構造が複雑であるため、一般に合成に多大な労力と時間が必要であり、機能分子としての実用化が困難である。新学術領域研究「反応集積化の合成化学、平成21~25年度」では、複数の化学反応を時間的・空間的に結合させる「反応集積化」により様々な効率的分子変換を実現した。本領域研究では、「反応集積化」を進展させ、革新的骨格構築法と合成戦略を開発することで、複雑な生物機能中分子の実用的な合成法を開発でき、中分子を実用的な生物機能分子として創製・利用が可能となり、社会に大きなインパクトを与えた。

Report

(6 results)
  • 2019 Annual Research Report   Final Research Report ( PDF )
  • 2018 Annual Research Report
  • 2017 Annual Research Report
  • 2016 Annual Research Report
  • 2015 Annual Research Report
  • Research Products

    (24 results)

All 2019 2018 2017 2016 Other

All Int'l Joint Research (7 results) Remarks (1 results) Funded Workshop (16 results)

  • [Int'l Joint Research] Academia Sinica/精華大学(中国)

    • Related Report
      2018 Annual Research Report
  • [Int'l Joint Research] University of Napoli Federico II(イタリア)

    • Related Report
      2018 Annual Research Report
  • [Int'l Joint Research] University of Napoli Federico II(イタリア)

    • Related Report
      2017 Annual Research Report
  • [Int'l Joint Research] Academia Sinica/精華大学(台湾)

    • Related Report
      2017 Annual Research Report
  • [Int'l Joint Research] University of Napoli Federico II(イタリア)

    • Related Report
      2016 Annual Research Report
  • [Int'l Joint Research] Academia Sinica(台湾)

    • Related Report
      2016 Annual Research Report
  • [Int'l Joint Research] 精華大学(台湾)

    • Related Report
      2016 Annual Research Report
  • [Remarks] 反応集積化が導く中分子戦略:高次生物機能分子の創製

    • URL

      http://www.middle-molecule.jp/

    • Related Report
      2015 Annual Research Report
  • [Funded Workshop] The 18th International Symposium on Novel Aromatic Compounds (ISNA-18)2019

    • Related Report
      2019 Annual Research Report
  • [Funded Workshop] The 27th International Society of Heterocyclic Chemistry Congress2019

    • Related Report
      2019 Annual Research Report
  • [Funded Workshop] 第14回アジア最先端有機化学国際会議ICCEOCA-142019

    • Related Report
      2019 Annual Research Report
  • [Funded Workshop] International Joint Symposium on Synthetic Organic Chemistry2019

    • Related Report
      2019 Annual Research Report
  • [Funded Workshop] The 4th International Symposium on Middle Molecular Strategy(ISMMS-4)2018

    • Related Report
      2018 Annual Research Report
  • [Funded Workshop] The 1st International Symposium on Middle Molecular Strategy for Young Scientists (ISMMSys-1)2018

    • Related Report
      2018 Annual Research Report
  • [Funded Workshop] International Symposium on Main Group Chemistry Directed towards Organic Synthesis(MACOS)2018

    • Related Report
      2018 Annual Research Report
  • [Funded Workshop] The 10th International Peptide Symposium2018

    • Related Report
      2018 Annual Research Report
  • [Funded Workshop] The 3rd International Symposium on Middle Molecular Strategy(ISMMS-3)2017

    • Related Report
      2017 Annual Research Report
  • [Funded Workshop] The 11th International Symposium on Integrated Synthesis(ISONIS-11)2017

    • Related Report
      2017 Annual Research Report
  • [Funded Workshop] 7thCCS-CSJ Young Chemists Forum 2017;Frontier in Organic Synthesis toward Middle Molecular Strategy-2017

    • Place of Presentation
      横浜
    • Related Report
      2016 Annual Research Report
  • [Funded Workshop] The 10th International Symposium on Integrated Synthesis(ISONIS-10)2016

    • Place of Presentation
      淡路
    • Year and Date
      2016-11-18
    • Related Report
      2016 Annual Research Report
  • [Funded Workshop] The 12th International Symposium on Organic Reactions (ISOR-12)2016

    • Place of Presentation
      京都
    • Year and Date
      2016-04-22
    • Related Report
      2016 Annual Research Report
  • [Funded Workshop] The 1st International Symposium on Middle Molecular Strategy (ISMMS-1)2016

    • Place of Presentation
      Osaka
    • Year and Date
      2016-02-06
    • Related Report
      2015 Annual Research Report
  • [Funded Workshop] The 2nd International Symposium on Middle Molecular Strategy(ISMMS-2)2016

    • Place of Presentation
      豊中
    • Related Report
      2016 Annual Research Report
  • [Funded Workshop] Satellite International Mini Symposium on Middle Molecular Strategy in Sendai2016

    • Place of Presentation
      仙台
    • Related Report
      2016 Annual Research Report

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Published: 2015-07-02   Modified: 2022-11-04  

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