宇宙からひも解く新たな生命制御機構の統合的理解

• Project Area: "LIVING IN SPACE" - Integral Understanding of life-regulation mechanism from "SPACE"
• Project/Area Number: 15H05935
• Research Category: Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)
• Allocation Type: Single-year Grants
• Review Section: Complex systems
• Research Institution: Japan Aerospace EXploration Agency
• Principal Investigator: 古川 聡 国立研究開発法人宇宙航空研究開発機構, 有人宇宙技術部門, 上席研究開発員 (20726260)
• Co-Investigator(Kenkyū-buntansha): 根井 充 国立研究開発法人量子科学技術研究開発機構, 放射線医学総合研究所 人材育成センター, センター長(定常) (10164659) ; 松崎 一葉 筑波大学, 医学医療系, 教授 (10229453) ; 日出間 純 東北大学, 生命科学研究科, 准教授 (20250855) ; 東端 晃 国立研究開発法人宇宙航空研究開発機構, 有人宇宙技術部門, 主任研究開発員 (30360720) ; 東谷 篤志 東北大学, 生命科学研究科, 教授 (40212162) ; 成瀬 恵治 岡山大学, 医歯薬学総合研究科, 教授 (40252233) ; 瀬原 淳子 京都大学, ウイルス・再生医科学研究所, 教授 (60209038) ; 高橋 昭久 群馬大学, 重粒子線医学推進機構, 教授 (60275336) ; 井上 夏彦 国立研究開発法人宇宙航空研究開発機構, 有人宇宙技術部門, 主任研究開発員 (60277811) ; 長瀬 博 筑波大学, 国際統合睡眠医科学研究機構, 教授 (70383651) ; 森田 啓之 岐阜大学, 大学院医学系研究科, 教授 (80145044) ; 岩崎 賢一 日本大学, 医学部, 教授 (80287630) ; 那須 正夫 大阪大谷大学, 薬学部, 客員教授 (90218040) ; 村井 正 国立研究開発法人宇宙航空研究開発機構, 有人宇宙技術部門, 参事 (10748958) ; 嶋津 徹 国立研究開発法人宇宙航空研究開発機構, 有人宇宙技術部門, 主幹研究開発員 (20639158) ; 村上 敬司 国立研究開発法人宇宙航空研究開発機構, 有人宇宙技術部門, 主幹研究開発員 (40421870)
• Project Period (FY): 2015-06-29 – 2020-03-31
• Project Status: Granted (Fiscal Year 2019)
• Budget Amount: ¥72,410,000 (Direct Cost: ¥55,700,000、Indirect Cost: ¥16,710,000); Fiscal Year 2019: ¥14,820,000 (Direct Cost: ¥11,400,000、Indirect Cost: ¥3,420,000); Fiscal Year 2018: ¥18,200,000 (Direct Cost: ¥14,000,000、Indirect Cost: ¥4,200,000); Fiscal Year 2017: ¥15,340,000 (Direct Cost: ¥11,800,000、Indirect Cost: ¥3,540,000); Fiscal Year 2016: ¥16,770,000 (Direct Cost: ¥12,900,000、Indirect Cost: ¥3,870,000); Fiscal Year 2015: ¥7,280,000 (Direct Cost: ¥5,600,000、Indirect Cost: ¥1,680,000)
• Keywords: 特殊環境 / 社会医学 / ストレス / 微小重力 / 放射線 / 宇宙 / 無重力 / 微生物

Outline of Annual Research Achievements

長期宇宙滞在時、無重力の物理ストレスは筋萎縮や骨密度低下を、閉鎖環境の精神的ストレスは体内リズム不調を、放射線被ばく等の環境リスクはDNA 変異等をきたす。有人宇宙探査での超長期宇宙滞在に挑戦する時代にあって、これらは今解決すべき課題である。同時にこれら課題への深い理解は、地上の高齢化・ストレス社会における生命維持・恒常性の担保に貢献し、健康長寿社会につながる。
本領域では[A01～03]ならびに横断・補完的研究[B01]を加えた11の計画研究と28の公募研究の相乗的展開により、上記目的達成を目指している。
これまで、[A01]宇宙からひも解かれる生命分子基盤の理解では、細胞の重力応答をリアルタイム観察できる遠心蛍光顕微鏡システム開発(成瀬)、微小重力下で線虫TGF-β/DBL-1の発現が低下(東谷)、神経筋接合部の維持因子活性化の検出プローブを開発(瀬原)、骨代謝における重力応答機構の発見(茶谷)、視床下部摂食中枢活動のライブイメージ化(川上)等、[A02]生命体個体の高次恒常性・適応機構と生命医学への展開では、重力負荷による脳血流量の低下(岩崎)、宇宙飛行により前庭系を介した血圧調節機能低下(森田)、オレキシン1型受容体特異的拮抗薬リード化合物の発見、睡眠覚醒制御遺伝子sleepy の同定(長瀬)、閉鎖環境によるストレスマーカー候補の検出(古川)、宇宙長期飼育マウスの破骨細胞による骨破壊が亢進(篠原)等、[A03]宇宙環境によるリスク因子研究では、疑似無重力装置に各種放射線同期照射システムを構築 (高橋)、国際宇宙ステーションにおける微生物モニタリング(那須)等、[B01]では、クマムシの放射線耐性メカニズム解明(國枝)、放射線被ばくによる細胞ダメージの可視化(沢野)等があり、宇宙滞在はじめ極限的環境での生体維持機構やその基盤的研究が進んでいる。

Current Status of Research Progress

2: Research has progressed on the whole more than it was originally planned.

Reason

各班とも、ほぼ予定通り研究が進捗している。また、例えば以下のような、単独の研究チームではできないようなサイエンスを行うクリエイティブは研究領域ができてきている。
・A01-1班開発の、3Dクリノスタットや遠心装置に搭載可能な高性能・コンパクトな蛍光顕微鏡システム、あるいはA03-2班開発の放射線照射用クリノスタットを使用した上に、バイオイメージングも導入し、模擬微小重力と放射線両者の相互作用を調べる。
・横断的なオミックス解析
・統合閉鎖試験
さらに、外国への研究者派遣や、外国からの研究者招聘により、国際共同研究が始まっている。かつ、若手研究者合宿実施は、若手研究者交流促進や人材育成に貢献している。
以上の理由により、現状おおむね順調に進展していると考える。

Strategy for Future Research Activity

[A01][A02][A03]という研究の縦串に加え、横串として、H28年度から公募班として領域課題の横断・補完的研究[B01]が加わった。H30年度から新たな公募班30班が参画して本領域は41班となり、さらに有機的にオーバーラップする横串の階層性、「睡眠―リズム」、「メンタルストレス」、「脳―循環系」、「骨―運動」、「免疫系―微生物」、「生命維持―物質生産」、「重力―メカノ応答」、「代謝変化」、「筋―萎縮」、「宇宙放射線―損傷」を導入し、総花的になることなく、実質的な連携・共同研究ができる組織とし、研究を推進する。

Research Products

• [Int'l Joint Research] スタンフォード大学/ハーバード大学/バージニア大学(アメリカ合衆国)
• [Int'l Joint Research] ドイツ航空宇宙センター/マールブルグ大学/Institute of Aerospace Medicine(ドイツ)
• [Int'l Joint Research] パスツール研究所(フランス)
• [Int'l Joint Research] Institute of Science and Technology(オーストリア)
• [Int'l Joint Research] スウェーデン農業科学大学(スウェーデン)
• [Int'l Joint Research] スタンフォード大学/フロリダ州立大学/バージニア大学(アメリカ合衆国)
• [Int'l Joint Research] German Aerospace Center/マールブルグ大学/Institute of Aerospace Medicine(ドイツ)
• [Int'l Joint Research] パスツール研究所(フランス)
• [Int'l Joint Research] Institute of Science and Technology(オーストリア)
• [Journal Article] The choroid plexus is an important circadian clock component. (2018)
  • Author(s): Myung Jihwan、Schmal Christoph、Hong Sungho、Tsukizawa Yoshiaki、Rose Pia、Zhang Yong、Holtzman Michael J.、De Schutter Erik、Herzel Hanspeter、Bordyugov Grigory、Takumi Toru
  • Journal Title: Nature communications Volume: 9 Pages: 1062-1062
  • DOI: 10.1038/s41467-018-03507-2
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] HIF-1 maintains a functional relationship between pancreatic cancer cells and stromal fibroblasts by upregulating expression and secretion of Sonic hedgehog (2018)
  • Author(s): Katagiri Tomohiro、Kobayashi Minoru、Yoshimura Michio、Morinibu Akiyo、Itasaka Satoshi、Hiraoka Masahiro、Harada Hiroshi
  • Journal Title: Oncotarget Volume: 9 Pages: 10525-10535
  • DOI: 10.18632/oncotarget.24156
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Sleep/Wake Behaviors in Mice During Pregnancy and Pregnancy-Associated Hypertensive Mice (2018)
  • Author(s): Haruna Komiya, Chika Miyoshi, Kanako Iwasaki, Noriko Hotta-Hirashima, Aya Ikkyu, Satomi Kanno, Takato Honda, Masahiro Gosho, Hiromi Hamada, Toyomi Satoh, Akiyoshi Fukamizu, Hiromasa Funato, Masashi Yanagisawa
  • Journal Title: Sleep Volume: 41 Issue: 3 Pages: 1-1
  • DOI: 10.1093/sleep/zsx209
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Role of follistatin in muscle and bone alterations induced by gravity change in mice (2018)
  • Author(s): Kawao N, Morita H, Obata K, Tatsumi K, Kaji H.
  • Journal Title: J Cell Physiol Volume: 233 Pages: 1191-1201
  • DOI: 10.1002/jcp.25986
  • Peer Reviewed
• [Journal Article] Regulatory mechanisms of hypoxia-inducible factor 1 activity: Two decades of knowledge (2018)
  • Author(s): Koyasu Sho、Kobayashi Minoru、Goto Yoko、Hiraoka Masahiro、Harada Hiroshi
  • Journal Title: Cancer Science Volume: 109 Pages: 560-571
  • DOI: 10.1111/cas.13483
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Clinical features of otolith organ-specific vestibular dysfunction. (2018)
  • Author(s): Fujimoto Chisato、Suzuki Sayaka、Kinoshita Makoto、Egami Naoya、Sugasawa Keiko、Iwasaki Shinichi
  • Journal Title: Clin Neurophysiol Volume: 129 Pages: 238-245
  • DOI: 10.1016/j.clinph.2017.11.006
  • Peer Reviewed
• [Journal Article] Reactive oxygen species up-regulate expression of muscle atrophy-associated ubiquitin ligase Cbl-b in rat L6 skeletal muscle cells. (2018)
  • Author(s): Uchida, T., Sakashita, Y., Kitahata, K., Yamashita, Y., Tomida, C., Kimori, Y., Komatsu, A., Hirasaka, K., Ohno, A., Nakao, R., Higashitani, A., Higashibata, A., Ishioka, N., Shimazu, T., Kobayashi, T., Okumura, Y., Choi, I., Oarada, M., Mills, E. M., Teshima-Kondo, S., Takeda, S., Tanaka, E., Tanaka, K., Sokabe, M., and Nikawa, T.
  • Journal Title: Am J Physiol Cell Physiol. Volume: 印刷中
  • DOI: 10.1152/ajpcell.00184.2017
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Subclinical maternal depressive symptoms modulate right inferior frontal response to inferring affective mental states of adults but not of infants. (2018)
  • Author(s): Shimada K, Kasaba R, Fujisawa TX, Sakakibara N, Takiguchi S, Tomoda A
  • Journal Title: Journal of Affective Disorders Volume: 229 Pages: 32-40
  • DOI: 10.1016/j.jad.2017.12.031
  • Peer Reviewed / Open Access
• [Journal Article] Roles of irisin in the linkage from muscle to bone during mechanical unloading in mice. (2018)
  • Author(s): Kawao N, Moritake A, Tatsumi K, Kaji H.
  • Journal Title: Calcified Tissue International Volume: －
  • DOI: 10.1007/s00223-018-0387-3
  • Peer Reviewed / Open Access
• [Journal Article] Comparison among ultrasonic, electrical apparatus, and toxic chemicals for vestibular lesion in mice (2018)
  • Author(s): Yamaoka Yusuke、Abe Chikara、Morita Hironobu
  • Journal Title: Journal of Neuroscience Methods Volume: 295 Pages: 58-67
  • DOI: 10.1016/j.jneumeth.2017.11.021
  • Peer Reviewed / Open Access
• [Journal Article] Effects of hypergravity on gene levels in anti-gravity muscle and bone through the vestibular system in mice (2018)
  • Author(s): Kawao N, Morita H, Nishida K, Obata K, Tatsumi K, Kaji H
  • Journal Title: The Journal of Physiological Sciences Volume: -
  • DOI: 10.1007/s12576-017-0566-4
  • Peer Reviewed
• [Journal Article] Increased oxytocin-monomeric red fluorescent protein 1 fluorescent intensity with urocortin-like immunoreactivity in the hypothalamo-neurohypophysial system of aged transgenic rats (2018)
  • Author(s): Ohno S, Hashimoto H, Fujihara H, Fujiki N, Yoshimura M, Maruyama T, Motojima Y, Saito R, Ueno H, Sonoda S, Ohno M, Umezu Y, Hamamura A, Saeki S, Ueta Y.
  • Journal Title: Neurosci Res Volume: 128 Pages: 40-49
  • DOI: 10.1016/j.neures.2017.08.001
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Promoting Stem Sap Flow of Sweetpotatoes under Low Gravity with Forced Air Movements (2018)
  • Author(s): Tokuda, A., Kitaya, Y., Hirai, H., Yano, S.
  • Journal Title: Trans. JSASS Aerospace Tech. Japan Volume: 18 Issue: 1 Pages: 53-56
  • DOI: 10.2322/tastj.16.53
  • Peer Reviewed
• [Journal Article] Genetically Encoded Tools for Optical Dissection of the Mammalian Cell Cycle (2017)
  • Author(s): Sakaue-Sawano Asako、Yo Masahiro、Komatsu Naoki、Hiratsuka Toru、Kogure Takako、Hoshida Tetsushi、Goshima Naoki、Matsuda Michiyuki、Miyoshi Hiroyuki、Miyawaki Atsushi
  • Journal Title: Mol. Cell Volume: 68 Pages: 626-640
  • DOI: 10.1016/j.molcel.2017.10.001
  • Peer Reviewed
• [Journal Article] Activation of the hypothalamic feeding centre upon visual prey detection (2017)
  • Author(s): Muto Akira、Lal Pradeep、Ailani Deepak、Abe Gembu、Itoh Mari、Kawakami Koichi
  • Journal Title: Nature Communications Volume: 8 Pages: 15029-15029
  • DOI: 10.1038/ncomms15029
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Slow-wave sleep is controlled by a subset of nucleus accumbens core neurons in mice. (2017)
  • Author(s): Oishi Yo、Xu Qi、Wang Lu、Zhang Bin-Jia、Takahashi Koji、Takata Yohko、Luo Yan-Jia、Cherasse Yoan、Schiffmann Serge N.、de Kerchove d’Exaerde Alban、Urade Yoshihiro、Qu Wei-Min、Huang Zhi-Li、Lazarus Michael
  • Journal Title: Nat Commun Volume: 8 Pages: 1-12
  • DOI: 10.1038/s41467-017-00781-4
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Comparative genomics of the tardigrades Hypsibius dujardini and Ramazzottius varieornatus (2017)
  • Author(s): Yoshida Yuki、Koutsovoulos Georgios、Laetsch Dominik R.、Stevens Lewis、Kumar Sujai、Horikawa Daiki D.、Ishino Kyoko、Komine Shiori、Kunieda Takekazu、Tomita Masaru、Blaxter Mark、Arakawa Kazuharu
  • Journal Title: PLOS Biology Volume: 15
  • DOI: 10.1371/journal.pbio.2002266
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] A novel perivascular cell population in the zebrafish brain (2017)
  • Author(s): Galanternik Marina Venero、Castranova Daniel、Gore Aniket V、Blewett Nathan H、Jung Hyun Min、Stratman Amber N、Kirby Martha R、Iben James、Miller Mayumi F、Kawakami Koichi、Maraia Richard J、Weinstein Brant M
  • Journal Title: eLife Volume: 6
  • DOI: 10.7554/elife.24369
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Moran’s I quantifies spatio-temporal pattern formation in neural imaging data (2017)
  • Author(s): Schmal Christoph、Myung Jihwan、Herzel Hanspeter、Bordyugov Grigory
  • Journal Title: Bioinformatics Volume: 33 Pages: 3072-3079
  • DOI: 10.1093/bioinformatics/btx351
  • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
• [Journal Article] Arsenic-mediated hyperpigmented skin via NF-kappa B/Endothelin1 signaling in an originally developed hairless mouse model (2017)
  • Author(s): Yajima I, Kumasaka MY, Iida M, Osino R, Tanihata H, Al Hossain A MM, Ohgami N, Kato M.
  • Journal Title: Archives of Toxicology Volume: 91 Pages: 3507-16
  • DOI: 10.1007/s00204-017-1975-0
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] The emerging roles of the ubiquitination/deubiquitination system in tumor radioresistance regarding DNA damage responses, cell cycle regulation, hypoxic responses, and antioxidant properties: Insight into the development of novel radiosensitizing strategies (2017)
  • Author(s): Goto Yoko、Koyasu Sho、Kobayashi Minoru、Harada Hiroshi
  • Journal Title: Mutation Research Volume: 803-805 Pages: 76-81
  • DOI: 10.1016/j.mrfmmm.2017.07.007
  • Peer Reviewed
• [Journal Article] Neurotransmitters and neuropeptides in gonadal steroid receptor-expressing cells in medial preoptic area subregions of the male mouse (2017)
  • Author(s): Tsuneoka Yousuke、Yoshida Sachine、Takase Kenkichi、Oda Satoko、Kuroda Masaru、Funato Hiromasa
  • Journal Title: Scientific Reports Volume: 7 Pages: 1-13
  • DOI: 10.1038/s41598-017-10213-4
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Nuclear factor (erythroid derived 2)-like 2 activation increases exercise endurance capacity via redox modulation in skeletal muscles. (2017)
  • Author(s): Oh S, Komine S, Warabi E, Akiyama K, Ishii A, Ishige K, Mizokami Y, Kuga K, Horie M, Miwa Y, Iwawaki T, Yamamoto M, Shoda J
  • Journal Title: Sci Rep. Volume: 7 Pages: 12902-12902
  • DOI: 10.1038/s41598-017-12926-y
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Activation of endogenous arginine vasopressin neurons inhibit food intake: by using a novel transgenic rat line with DREADDs system. (2017)
  • Author(s): Yoshimura Mitsuhiro、Nishimura Kazuaki、Nishimura Haruki、Sonoda Satomi、Ueno Hiromichi、Motojima Yasuhito、Saito Reiko、Maruyama Takashi、Nonaka Yuki、Ueta Yoichi
  • Journal Title: Sci Rep. Volume: 7 Pages: 1-10
  • DOI: 10.1038/s41598-017-16049-2
  • Peer Reviewed / Open Access
• [Journal Article] Oral exposure to arsenic causes hearing loss in young people aged 12-29 years and in young mice (2017)
  • Author(s): Li X, Ohgami N, Omata Y, Yajima I, Iida M, Oshino R, Ohnuma S, Ahsan N, Akhand AA, Kato M.
  • Journal Title: Scientific Reports Volume: 7 Pages: 6844-6844
  • DOI: 10.1038/s41598-017-06096-0
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] UCHL1-HIF-1 axis-mediated antioxidant property of cancer cells as a therapeutic target for radiosensitization (2017)
  • Author(s): Nakashima Ryota、Goto Yoko、Koyasu Sho、Kobayashi Minoru、Morinibu Akiyo、Yoshimura Michio、Hiraoka Masahiro、Hammond Ester M.、Harada Hiroshi
  • Journal Title: Scientific Reports Volume: 7 Pages: 6879-6879
  • DOI: 10.1038/s41598-017-06605-1
  • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
• [Journal Article] Heat-Induced Calcium Leakage Causes Mitochondrial Damage inCaenorhabditis elegansBody-Wall Muscles (2017)
  • Author(s): Momma Kenta、Homma Takashi、Isaka Ruri、Sudevan Surabhi、Higashitani Atsushi
  • Journal Title: Genetics Volume: 206 Pages: 1985-1994
  • DOI: 10.1534/genetics.117.202747
  • Peer Reviewed / Open Access
• [Journal Article] Cryptoendolithic Antarctic Black Fungus Cryomyces antarcticus Irradiated with Accelerated Helium Ions: Survival and Metabolic Activity, DNA and Ultrastructural Damage (2017)
  • Author(s): Claudia Pacelli, Ralf Moeller, Akira Fujimori et al.
  • Journal Title: Frontiers in Microbiology Volume: 8 Pages: 2002-2002
  • DOI: 10.3389/fmicb.2017.02002
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] A circadian clock gene, PER2, activates HIF-1 as an effector molecule for recruitment of HIF-1α to promoter regions of its downstream genes (2017)
  • Author(s): Kobayashi Minoru、Morinibu Akiyo、Koyasu Sho、Goto Yoko、Hiraoka Masahiro、Harada Hiroshi
  • Journal Title: The FEBS Journal Volume: 284 Pages: 3804-3816
  • DOI: 10.1111/febs.14280
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Growth responses of wasabi plantlets under different temperature regimes during photoautotrophic micropropagation (2017)
  • Author(s): Hoang NN, Kitaya Y, Endo R et al.
  • Journal Title: Eco-Engineering Volume: 29(4) Pages: 125-129
  • Peer Reviewed
• [Journal Article] Running training experience attenuates disuse atrophy in fast-twitch skeletal muscles of rats (2017)
  • Author(s): Nakamura Keisuke、Ohsawa Ikumi、Masuzawa Ryo、Konno Ryotaro、Watanabe Atsuya、Kawano Fuminori
  • Journal Title: Journal of Applied Physiology Volume: 123 Pages: 902-913
  • DOI: 10.1152/japplphysiol.00289.2017
  • Peer Reviewed / Open Access
• [Journal Article] Exposure to diphtheria toxin during the juvenile period impairs both inner and outer hair cells in C57BL/6 mice. (2017)
  • Author(s): Konishi H, Ohgami N, Matsushita A, Kondo Y, Aoyama Y, Kobayashi M, Nagai T, Ugawa S, Yamada K, Kato M, Kiyama H
  • Journal Title: Neuroscience. Volume: 印刷中 Pages: 15-23
  • DOI: 10.1016/j.neuroscience.2017.03.028
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] Upregulation of matrix metalloproteinase triggers transdifferentiation of retinal pigmented epithelial cells in Xenopus laevis: A Link between inflammatory response and regeneration (2017)
  • Author(s): Naitoh Hanako、Suganuma Yukari、Ueda Yoko、Sato Takahiko、Hiramuki Yosuke、Fujisawa-Sehara Atsuko、Taketani Shigeru、Araki Masasuke
  • Journal Title: Developmental Neurobiology Volume: 77 Pages: 1086-1100
  • DOI: 10.1002/dneu.22497
  • Peer Reviewed / Open Access
• [Journal Article] Manganese-Mediated Decrease in Levels of c-RET and Tyrosine Hydroxylase Expression In Vitro (2017)
  • Author(s): Kumasaka MY, Yajima I, Ohgami N, Ninomiya H, Iida M, Li X, Oshino R, Tanihata H, Yoshinaga M, Kato M.
  • Journal Title: Neurotoxicity Research Volume: 32 Pages: 661-670
  • DOI: 10.1007/s12640-017-9783-0
  • Peer Reviewed
• [Journal Article] Encoding seasonal information in a two‐oscillator model of the multi‐oscillator circadian clock (2017)
  • Author(s): Myung Jihwan、Pauls Scott D.
  • Journal Title: European Journal of Neuroscience Volume: ? Pages: 1-10
  • DOI: 10.1111/ejn.13697
  • Peer Reviewed / Int'l Joint Research / Acknowledgement Compliant
• [Journal Article] Essential structure of orexin 1 receptor antagonist YNT-707, Part I: Role of the 4,5-epoxy ring for binding with orexin 1 receptor (2017)
  • Author(s): Yamamoto Naoshi、Ohrui Sayaka、Okada Takahiro、Yata Masahiro、Saitoh Tsuyoshi、Kutsumura Noriki、Nagumo Yasuyuki、Irukayama-Tomobe Yoko、Ogawa Yasuhiro、Ishikawa Yukiko、Watanabe Yurie、Hayakawa Daichi、Gouda Hiroaki、Yanagisawa Masashi、Nagase Hiroshi
  • Journal Title: Bioorg. Med. Chem. Lett Volume: 27 Pages: 4176-4179
  • DOI: 10.1016/j.bmcl.2017.07.011
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Low and High LET Ionizing Radiation-Induced Delayed Homologous Recombination Persists for Two Weeks Before Resolving. (2017)
  • Author(s): Allen Christopher P.、Hirakawa Hirokazu、Nakajima Nakako Izumi、Moore Sophia、Nie Jingyi、Sharma Neelam、Sugiura Mayumi、Hoki Yuko、Araki Ryoko、Abe Masumi、Okayasu Ryuichi、Fujimori Akira、Nickoloff Jac A.
  • Journal Title: Radiation Research Volume: 188 Pages: 82-93
  • DOI: 10.1667/rr14748.1
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Radiation exposure enhances hepatocyte proliferation in neonatal mice but not in adult mice (2017)
  • Author(s): Shang Yi、Sawa Yurika、Blyth Benjamin J.、Tsuruoka Chizuru、Nogawa Hiroyuki、Shimada Yoshiya、Kakinuma Shizuko
  • Journal Title: Radiation Research Volume: 188 Pages: 235-241
  • DOI: 10.1667/rr14563.1
  • Peer Reviewed
• [Journal Article] Antiangiogenic agent sunitinib induces epithelial to mesenchymal transition and accelerates motility of colorectal cancer cells (2017)
  • Author(s): Chisato Tomida, Naoko Yamagishi, Hikaru Nagano, Takayuki Uchida, Ayako Ohno, Katsuya Hirasaka, Takeshi Nikawa, Shigetada Teshima-Kondo
  • Journal Title: THE JOUNAL OF MEDICAL INVESTIGATION Volume: 64 Issue: 3.4 Pages: 250-254
  • DOI: 10.2152/jmi.64.250
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Regorafenib induces adaptive resistance of colorectal cancer cells via inhibition of vascular endothelial growth factor receptor (2017)
  • Author(s): Tomida Chisato、Nagano Hikaru、Yamagishi Naoko、Uchida Takayuki、Ohno Ayako、Hirasaka Katsuya、Nikawa Takeshi、Teshima-Kondo Shigetada
  • Journal Title: THE JOUNAL OF MEDICAL INVESTIGATION Volume: 64 Issue: 3.4 Pages: 262-265
  • DOI: 10.2152/jmi.64.262
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Oxygen Enhancement Ratio in Radiation-Induced Initial DSBs by an Optimized Flow Cytometry-based Gamma-H2AX Analysis in A549 Human Cancer Cells. (2017)
  • Author(s): Sunada Shigeaki、Hirakawa Hirokazu、Fujimori Akira、Uesaka Mitsuru、Okayasu Ryuichi
  • Journal Title: Radiation Research Volume: 188 Pages: 591-594
  • DOI: 10.1667/rr14824.1
  • Peer Reviewed
• [Journal Article] Investigation of the relative biological effectiveness and uniform isobiological killing effects of irradiation with a clinical carbon SOBP beam on DNA repair deficient CHO cells. (2017)
  • Author(s): Sunada Shigeaki、Cartwright Ian M.、Hirakawa Hirokazu、Fujimori Akira、Uesaka Mitsuru、Kato Takamitsu A.
  • Journal Title: Oncology Letters Volume: 13 Pages: 4911-4916
  • DOI: 10.3892/ol.2017.6072
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Simple generation of hairless mice for in vivo imaging. (2017)
  • Author(s): Hoshino Y, Mizuno S, Kato K, Mizuno-Iijima S, Tanimoto Y, Ishida M, Kajiwara N, Sakasai T, Miwa Y, Takahashi S, Yagami KI, Sugiyama F
  • Journal Title: Exp Anim Volume: 66(4) Issue: 4 Pages: 437-445
  • DOI: 10.1538/expanim.17-0049
  • Peer Reviewed / Open Access
• [Journal Article] Research and development of radioprotective agents: A mini-review (2017)
  • Author(s): Fazliana Mohd Saaya, Takanori Katsube, Yi Xie, Kaoru Tanaka, Kazuko Fujita, Bing Wang
  • Journal Title: International Journal of Radiology Volume: 4 (2-3) Pages: 128-138
  • Peer Reviewed
• [Journal Article] Forward genetic analysis of sleep in randomly mutagenized mice. (2017)
  • Author(s): Funato H, et al.
  • Journal Title: Nature. Volume: 539 Issue: 46 Pages: 378-383
  • DOI: 10.1038/nature20142
  • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
• [Journal Article] Extremotolerant tardigrade genome and improved radiotolerance of human cultured cells by tardigrade-unique protein. (2017)
  • Author(s): Kunieda T et al.
  • Journal Title: Nat Commun. Volume: 7 Pages: 12808-12808
  • DOI: 10.1038/ncomms12808
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Entire photodamaged chloroplasts are transported to the central vacuole by autophagy. (2017)
  • Author(s): Izumi M, Ishida H, Nakamura S and Hidema J
  • Journal Title: The Plant Cell Volume: 29(2) Pages: 377-394
  • DOI: 10.1105/tpc.16.00637
  • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
• [Journal Article] Moxd1 is a marker for sexual dimorphism in the medial preoptic area, bed nucleus of the stria terminalis and medial amygdala. (2017)
  • Author(s): Tsuneoka Y and Funato H et al.
  • Journal Title: Frontiers in Ｎeuroanatomy Volume: 11 Pages: 1-13
  • DOI: 10.3389/fnana.2017.00026
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Secretome analysis to elucidate metalloprotease-dependent ectodomain shedding of glycoproteins during neuronal differentiation. (2017)
  • Author(s): Tsumagari K, Shirakabe K, Ogura M, Sato F, Ishihama Y and Sehara-Fujisawa A
  • Journal Title: Genes to Cells Volume: 22(2) Pages: 237-244
  • DOI: 10.1111/gtc.12466
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Impact of a simulated gravity load for atmospheric reentry-10 g for 2 minutes-on conscious mouse (2017)
  • Author(s): Morita H, Yamaguchi A, Shiba D, Shirakawa M and Takahashi S
  • Journal Title: J Physiol Sci Volume: Epub ahead of print Pages: 531-537
  • DOI: 10.1007/s12576-017-0526-z
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] Design and Synthesis of Potent and Highly Selective Orexin 1 Receptor Antagonists with a Morphinan Skeleton and their Pharmacologies (2017)
  • Author(s): Nagase H and Yanagisawa M et al.
  • Journal Title: Journal of Medicinal Chemistry Volume: 60 Pages: 1018-1040
  • DOI: 10.1021/acs.jmedchem.6b01418
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] Development and performance evaluation of a three-dimensional clinostat synchronized heavy-ion irradiation system. (2017)
  • Author(s): Ikeda H, Hidema J and Takahashi A et al.
  • Journal Title: Life Sci Space Res (Amst). Volume: 12 Pages: 51-60
  • DOI: 10.1016/j.lssr.2017.01.003
  • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
• [Journal Article] Risk assessment of neonatal exposure to low frequency noise based on balance in mice. (2017)
  • Author(s): Ohgami N et al.
  • Journal Title: Front Behav Neurosci Volume: 11 Pages: 30-30
  • DOI: 10.3389/fnbeh.2017.00030
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] A New System for Three-dimensional Clinostat Synchronized X-irradiation with a High-speed Shutter for Space Radiation Research (2017)
  • Author(s): Ikeda H, Hidema J and Takahashi A et al.
  • Journal Title: Biol Sci Space Volume: 30 Issue: 0 Pages: 8-16
  • DOI: 10.2187/bss.30.8
  • Year and Date: 2017-01-31
  • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
• [Journal Article] denti cation of mutations through dominant screening for obesity using C57BL/6 substrains (2016)
  • Author(s): Hossain MS., Funato H, and Yanagisawa M et al.
  • Journal Title: Scientific Report Volume: 6 Pages: 1-15
  • DOI: 10.1038/srep32453
  • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
• [Journal Article] Long-term exposure to microgravity impairs vestibulo-cardiovascular reflex (2016)
  • Author(s): Morita H, Abe C and Tanaka K
  • Journal Title: Scientific Reports Volume: 6 Pages: 33405-33405
  • DOI: 10.1038/srep33405
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Acute transcriptional up-regulation specific to osteoblasts/osteoclasts in medaka fish immediately after exposure to microgravity. (2016)
  • Author(s): Chatani M et al.
  • Journal Title: Scientific Reports Volume: 6 Pages: 1-14
  • DOI: 10.1038/srep39545
  • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
• [Journal Article] Manganese-mediated acceleration of age-related hearing loss in mice (2016)
  • Author(s): Ohgami N et al.
  • Journal Title: Sci Rep Volume: 6 Pages: 36306-36306
  • DOI: 10.1038/srep36306
  • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
• [Journal Article] The vestibular system is critical for the changes in muscle and bone induced by hypergravity in mice. (2016)
  • Author(s): Kawao N, Morita H, Obata K, Tamura Y, Okumoto K and Kaji H
  • Journal Title: Physiol Rep. Volume: 4(19) Pages: 12979-12979
  • DOI: 10.14814/phy2.12979
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Identification of embryonic precursor cells that differentiate into thymic epithelial cells expressing autoimmune regulator. (2016)
  • Author(s): Akiyama N, Takizawa N, Miyauchi M, Yanai H, Tateishi R, Shinzawa M, Yoshinaga R, Kurihara M, Demizu Y, Yasuda H, Yagi S, Wu G, Matsumoto M, Sakamoto R, Yoshida N, Penninger JM, Kobayashi Y, Inoue J, Akiyama T.
  • Journal Title: J Exp Med Volume: 213 Pages: 1441-1458
  • DOI: 10.1084/jem.20151780
  • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
• [Journal Article] LY6E: a conductor of malignant tumor growth through modulation of the PTEN/PI3K/Akt/HIF-1 axis. (2016)
  • Author(s): Harada H et al.
  • Journal Title: Oncotargets Volume: 7(40) Pages: 11670-11670
  • DOI: 10.18632/oncotarget.11670
  • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
• [Journal Article] ADAM12-deficient zebrafish exhibit retardation in body growth at the juvenile stage without developmental defects (2016)
  • Author(s): Tokumasu Y, Iida A, Wang Z, Ansai S, Kinoshita M, and Sehara-Fujisawa A
  • Journal Title: Development, Growth & Differentiation Volume: 58(4) Pages: 409-421
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] Novel roles of FKBP5 in muscle alteration induced by gravity change in mice. (2016)
  • Author(s): Shimode T, Kawao N, Tamura Y, Morita H and Kaji H
  • Journal Title: Biochem Biophys Res Commun. Volume: 479 Pages: 602-606
  • DOI: 10.1016/j.bbrc.2016.09.126
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] Characterization of Fungi Isolated from the Equipment Used in the International Space Station or Space Shuttle (2016)
  • Author(s): Satoh K, Yamazaki T and Makimura K et al.
  • Journal Title: Microbiology and Immunology Volume: 60(5) Pages: 295-302
  • DOI: 10.1111/1348-0421.12375
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Fluorescence-activated cell sorting and gene expression profiling of GFP-positive cells from transgenic zebrafish lines (2016)
  • Author(s): Tanabe H and Kawakami K et al.
  • Journal Title: Methods in Molecular Biology Volume: 1451 Pages: 93-106
  • DOI: 10.1007/978-1-4939-3771-4_7
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] Microgravity elicits reproducible alterations in cytoskeletal and metabolic gene and protein expression in space-flown Caenorhabditis elegans. (2016)
  • Author(s): Higashibata A., Hashizume T., Nemoto K., Higashitani N., Etheridge T., Mori C., Harada S., Sugimoto T., Szewczyk NJ., Baba SA., Mogami Y., Fukui K., Higashitani A.
  • Journal Title: npj Microgravity Volume: 2 Pages: 15022-15022
  • DOI: 10.1038/npjmgrav.2015.22
  • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
• [Journal Article] Fluid dynamics alter Caenorhabditis elegans body length via TGF-β/DBL-1 neuromuscular signaling. (2016)
  • Author(s): Harada S., Hashizume T., Nemoto K., Shao Z., Higashitani N., Etheridge T., Szewczyk NJ., Fukui K., Higashibata A., Higashitani A.
  • Journal Title: npj Microgravity Volume: 2 Pages: 16006-16006
  • DOI: 10.1038/npjmgrav.2016.6
  • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
• [Journal Article] The relationship between widespread changes in gravity and cerebral blood flow. (2016)
  • Author(s): Ogawa Y, Yanagida R, Ueda K, Aoki K, Iwasaki K
  • Journal Title: Environmental Health and Preventive Medicine Volume: in press
  • DOI: 10.1007/s12199-016-0513-7
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] Intrathecal morphine-3-glucuronide-induced nociceptive behavior via Delta-2 opioid receptors in the spinal cord (2016)
  • Author(s): Takaaki Komatsu, Soh Katsuyama, Hiroshi Nagase, Hirokazu Mizoguchi, Chikai Sakurada, Minoru Tsuzuki, Shinobu Sakurada, Tsukasa Sakurada
  • Journal Title: Pharmacol. Biochem. Be. Volume: 140 Pages: 68-74
  • DOI: 10.1016/j.pbb.2015.10.010
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Opioid System in the Lateral Hypothalamus Regulate Feeding Behavior Through Orexin and GABA Neurons (2016)
  • Author(s): Ardianto C, Yonemochi N, Yamamoto S, Yang L, Takenoya F, Shioda S, Nagase H, Ikeda H, Kamei J.
  • Journal Title: NeuroScience Volume: 320 Pages: 183-193
  • DOI: 10.1016/j.neuroscience.2016.02.002
  • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
• [Journal Article] High-fat diet feeding alters olfactory-, social- and reward-related behaviors of mice independent of obesity (2016)
  • Author(s): Takase K, Tsuneoka Y, Oda S, Kuroda M, Funato H
  • Journal Title: Obesity (Silver Spring, Md.) Volume: 4 Pages: 886-894
  • DOI: 10.1002/oby.21441
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] Sleep as a biological problem: an overview of frontiers in sleep research. (2016)
  • Author(s): Kanda T, Tsujino N, Kuramoto E, Koyama Y, Susaki EA, Chikahisa S, Funato H
  • Journal Title: The journal of physiological sciences : JPS Volume: 66 Pages: 1-13
  • DOI: 10.1007/s12576-015-0414-3
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Nighttime Administration of Nicotine Improves Hepatic Glucose Metabolism via the Hypothalamic Orexin System in Mice (2016)
  • Author(s): Tsuneki H, Nagata T, Fujita M, Kon K, Wu N, Takatsuki M, Yamaguchi K, Wada T, Nishijo H, Yanagisawa M, Sakurai T, Sasaoka T.
  • Journal Title: Endocrinology Volume: 157 Pages: 195-206
  • DOI: 10.1210/en.2015-1488
  • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
• [Journal Article] Plant nuclei move to escape ultraviolet-induced DNA damage and cell death (2016)
  • Author(s): Iwabuchi K., Hidema J., Tamura K., Takagi S., and Hara-Nishimura I.
  • Journal Title: Plant Physiol. Volume: 170 Issue: 2 Pages: 678-685
  • DOI: 10.1104/pp.15.01400
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] A critical role of Dectin-1 in hypersensitivity pneumonitis (2016)
  • Author(s): Higashino-Kameda M, Yabe-Wada T, Matsuba S, Takeda K, Anzawa K, Mochizuki T, Makimura K, Saijo S, Iwakura Y, Toga H, Nakamura A.
  • Journal Title: Inflamm Res. Volume: 65 Pages: 235-244
  • DOI: 10.1007/s00011-015-0910-1
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Comprehensive analysis of the skin fungal microbiota of astronauts during a half-year stay at the International Space Station (2016)
  • Author(s): Sugita T, Yamazaki T, Makimura K, Cho O, Yamada S, Ohshima H, Mukai C
  • Journal Title: Medical Mycology Volume: published online Pages: 232-239
  • DOI: 10.1093/mmy/myv121
  • Peer Reviewed / Open Access
• [Journal Article] Phylogenetic analysis of dermatophyte species using DNA sequence polymorphism in calmodulin gene (2016)
  • Author(s): Ahmadi B, Mirhendi H, Makimura K, de Hoog GS, Shidfar MR, Nouripour-Sisakht S, Jalalizand N
  • Journal Title: Med Mycol Volume: published online
  • DOI: 10.1093/mmy/myw004
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Fatal Cyberlindnera fabianii fungemia in a patient with mixed phenotype acute leukemia after umbilical cord blood transplantation (2016)
  • Author(s): Katagiri S, Gotoh M, Tone K, Akahane D, Ito Y, Ohyashiki K, Makimura K
  • Journal Title: Int J Hematol Volume: published online
  • DOI: 10.1007/s12185-016-1953-y
  • Peer Reviewed
• [Journal Article] Epidemiological aspects of Dermatophytosis in Khusestan, southwestern Iran, an update (2016)
  • Author(s): Razaei-Matehkolaei A, Rafiei A, Makimura K, Graser Y, Gharghani M, Sadeghi-Nejad B
  • Journal Title: Mycopathologia Volume: published online
  • DOI: 10.1007/s11046-016-9990-x
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Mest but not miR-335 affects skeletal muscle growth and regeneration (2015)
  • Author(s): Hiramuki Y, Sato T, Furuta Y, Surani A, Sehara-Fujisawa A
  • Journal Title: PLoS One Volume: 10
  • DOI: 10.1371/journal.pone.0130436
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] High-resolution live imaging reveals axon-glia interactions during peripheral nerve injury and repair (2015)
  • Author(s): Xiao Y, Faucherre A, Pola-Morell L, Heddleston J, Liu T, Chew T, Sato F, Sehara-Fujisawa A, Kawakami K, Lopez-Schier H
  • Journal Title: Disease Models & Mechanisms Volume: 8 Pages: 553-564
  • DOI: 10.1242/dmm.018184
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Early pathogenesis of Duchenne muscular dystrophy modelled in patient-derived human induced pluripotent stem cells. (2015)
  • Author(s): Shoji E, Sakurai H, Nishino T, Nakahata T, Heike T, Awaya T, Fujii N, Manabe Y, Matsuo M, Sehara-Fujisawa A
  • Journal Title: Scientific Reports. Volume: 5 Pages: 12831-12831
  • DOI: 10.1038/srep12831
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Molecular dynamics study on protein–water interplay in the mechanogating of the bacterial mechanosensitive channel MscL (2015)
  • Author(s): Sawada Y, Sokabe M
  • Journal Title: Eur J Biophys Volume: 44 Pages: 531-43
  • DOI: 10.1007/s00249-015-1065-2
  • Peer Reviewed / Open Access
• [Journal Article] Unidirectional incorporation of a bacterial mechanosensitive channel into liposomal membranes (2015)
  • Author(s): Nomura T, Cox CD, Bavi N, Sokabe M and Martinac B
  • Journal Title: FASEB J Volume: 29 Pages: 4334-4345
  • DOI: 10.1096/fj.15-275198
  • Peer Reviewed / Int'l Joint Research / Acknowledgement Compliant
• [Journal Article] Ion Channels Activated by Mechanical Forces in Bacterial and Eukaryotic Cells (2015)
  • Author(s): Sokabe M, Sawada M, Kobayashi T
  • Journal Title: Subcell Biochem: high Pressure Bioscience-Basic Concepts, Applications and Frontiers Volume: 72 Pages: 613-26
  • DOI: 10.1007/978-94-017-9918-8_28
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] Hypergravity Provokes a Temporary Reduction in CD4+CD8+ Thymocyte Number and a Persistent Decrease in Medullary Thymic Epithelial Cell Frequency in Mice. (2015)
  • Author(s): Tateishi R, Akiyama N, Miyauchi M, Yoshinaga R, Sasanuma H, Kudo T, Shimbo M, Shinohara M, Obata K, Inoue J, Shirakawa M, Shiba D, Asahara H, Yoshida N, Takahashi S, Morita H, Akiyama T
  • Journal Title: PLoS One Volume: 10 Pages: 1-17
  • DOI: 10.1371/journal.pone.0141650
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Feasibility of a Short-Arm Centrifuge for Mouse Hypergravity Experiments. (2015)
  • Author(s): Morita H, et al.
  • Journal Title: PLoS One Volume: 10(7): e133981 Pages: 1-14
  • DOI: 10.1371/journal.pone.0133981
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Role of osteoclasis in the heterotopic ossification enhanced by fobrodysplasia ossificans progressiva-related activin-like kinase 2 mutation in mice (2015)
  • Author(s): Kawao N, Yano M, Tamura Y, Okumoto K, Okada K, Kaji H
  • Journal Title: J Bone Miner Metab Volume: epub
  • Peer Reviewed
• [Journal Article] Clinical charasteristics of patients with abnornal ocular/cervical vestibular evoked myogenic potentials in the presence of normal caloric responses (2015)
  • Author(s): Iwasaki S, Fujimoto C, Kinoshita M, Kamogashira T, Egami N, Yamasoba T
  • Journal Title: Ann Otol Rhinol Laryngol Volume: 124 Pages: 458-65
  • Peer Reviewed
• [Journal Article] The effect of aging on the center-of-pressure power spectrum in foam posturography (2015)
  • Author(s): Fujimoto C, Egami N, Demura S, Yamasoba T, Iwasaki S.
  • Journal Title: Neuroscience letters Volume: 585 Pages: 92-7
  • DOI: 10.1016/j.neulet.2014.11.033
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] Transformation of naltrexone into mesembrane and investigation of the binding properties of its intermediate derivatives to opioid receptors (2015)
  • Author(s): Konoura K, Fujii H, Imaide S, Gouda H, Hirayama S, Hirono S, Nagase H
  • Journal Title: Bioorg. Med. Chem. Volume: 23 Pages: 439-448
  • DOI: 10.1016/j.bmc.2014.12.032
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Peripheral opioid antagonist enhances the effect of anti-tumor drug by blocking a cell growth-suppressive pathway in vivo. (2015)
  • Author(s): Masami Suzuki, Fumiko Chiwaki, Yumi Sawada, Maho Ashikawa, Kazuhiko Aoyagi, Takeshi Fujita, Kazuyoshi Yanagihara, Masayuki Komatsu, Minoru Narita, Tsutomu Suzuki, Hiroshi Nagase, Ryoji Kushima, Hiromi Sakamoto, Takeo Fukagawa, Hitoshi Katai, Hitoshi Nakagama, Teruhiko Yoshida, Yasuhito Uezono, Hiroki Sasaki
  • Journal Title: PLoS One. Volume: 10(4) Pages: 1-18
  • DOI: 10.1371/journal.pone.0123407
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Naltrindole derivatives with fluorinated ethyl substituents on 17-nitrogen as delta opioid receptor inverse agonist (2015)
  • Author(s): Nemoto T, Iihara Y, Hirayama S, Iwai T, Higashi E, Fujii H, Nagase H
  • Journal Title: Bioorg Med Chem Lett Volume: 25 Pages: 2927-30
  • DOI: 10.1016/j.bmcl.2015.05.038
  • Peer Reviewed
• [Journal Article] Naltrindole derivatives with fluorinated ethyl substituents on 17-nitrogen as δ opioid receptor inverse agonist (2015)
  • Author(s): Kutsumura, N.; Nakajima, R.; Koyama, Y.; Miyata, Y.; Saitoh, T.; Yamamoto, N.; Iwata, S.; Fujii, H.; Nagase, H.
  • Journal Title: Bioorg. Med. Chem. Lett Volume: 25 Pages: 4890-2
  • DOI: 10.1016/j.bmcl.2015.06.002
  • Peer Reviewed / Int'l Joint Research / Acknowledgement Compliant
• [Journal Article] Inhibition of opioid systems in the hypothalamus as well as the mesolimbic area suppresses feeding behavior of mice (2015)
  • Author(s): Ikeda H, Ardianto C, Yonemochi N, Yang L, Ohashi T, Ikegami M, Nagase H, Kamei J
  • Journal Title: NeuroScience Volume: 311 Pages: 9-21
  • DOI: 10.1016/j.neuroscience.2015.10.002
  • Peer Reviewed / Int'l Joint Research / Acknowledgement Compliant
• [Journal Article] Design and synthesis of non-peptide, selective orexin receptor 2 agonists (2015)
  • Author(s): Nagahara T, Saitoh T, Kutsumura N, Irukayama-Tomobe Y, Ogawa Y, Kuroda D, Gouda H, Kumagai H, Fujii H, Yanagisawa M, Nagase H
  • Journal Title: J Med Chem. Volume: 58 Pages: 7931-37
  • DOI: 10.1021/acs.jmedchem.5b00988
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] Synthesis of new opioid derivatives with a propellane skeleton and their pharmacologies: Part 5, novel pentacyclic propellane derivatives with a 6-amide side chain (2015)
  • Author(s): Nakajima R, Yamamoto N, Hirayama S, Iwai T, Saitoh A, Nagumo Y, Fujii H, Nagase H.
  • Journal Title: Bioorg. Med. Chem. Volume: 23 Pages: 6271-6279
  • DOI: 10.1016/j.bmc.2015.08.036
  • Peer Reviewed / Int'l Joint Research / Acknowledgement Compliant
• [Journal Article] Endothelin-1 as a master regulator of whole-body Na+ homeostasis (2015)
  • Author(s): Speed JS, Heimlich JB, Hyndman KA, Fox BM, Patel V, Yanagisawa M, Pollock JS, Titze JM, Pollock DM
  • Journal Title: FASEB J Volume: 29 Pages: 4937-44
  • DOI: 10.1096/fj.15-276584
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Functional ETA-ETB receptor cross-talk in basilar artery in situ from ETB receptor deficient rats (2015)
  • Author(s): Yoon S, Gariepy CE, Yanagisawa M, Zuccarello M, Rapoport RM
  • Journal Title: J Cardiovasc Pharmacol Volume: epub
  • Peer Reviewed
• [Journal Article] 長期宇宙滞在時に解決すべき医学的課題～循環制御関連を中心に～ (2015)
  • Author(s): 古川聡
  • Journal Title: 循環制御 Volume: 36 Pages: 66-8
  • Open Access
• [Journal Article] UV-B-Induced CPD Photolyase Gene Expression is Regulated by UVR8-Dependent and -Independent Pathways in Arabidopsis (2015)
  • Author(s): Li N, Teranishi M, Yamaguchi Ｈ, Matsushita T, Watahiki MK, Tsuge T, Li SS, Hidema J
  • Journal Title: Plant Cell Physiol. Volume: 56 Pages: 2014-2023
  • DOI: 10.1093/pcp/pcv121
  • Peer Reviewed / Int'l Joint Research / Acknowledgement Compliant
• [Journal Article] From Arabidopsis to cereal crops: Conservation of chloroplast protein degradation by autophagy indicates its fundamental role in plant productivity (2015)
  • Author(s): Izumi M, Hidema J, Ishida H
  • Journal Title: Plant Signal Behav. Volume: 10
  • DOI: 10.1080/15592324.2015.1101199
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Combining carbon ion irradiation and non-homologous end-joining repair inhibitor NU7026 efficiently kills cancer cells (2015)
  • Author(s): Ma H, Takahashi A, Yoshida Y, Adachi A, Kanai T, Ohno T, Nakano T.
  • Journal Title: Radiat Oncol Volume: 10 Pages: 225-225
  • DOI: 10.1186/s13014-015-0536-z
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Targeting of Carbon Ion-Induced G2 Checkpoint Activation in Lung Cancer Cells Using Wee-1 Inhibitor MK-1775 (2015)
  • Author(s): Ma H, Takahashi A, Sejimo Y, Adachi A, Kubo N, Isono M, Yoshida Y, Kanai T, Ohno T, Nakano T.
  • Journal Title: Radiat Res Volume: 184 Pages: 660-669
  • DOI: 10.1667/rr14171.1
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Genetic and phenotypic analyses of Calcineurin A subunit in Arthroderma vanbreuseghemii (2015)
  • Author(s): Alshahni MM, Shimizu K, Yoshimoto M, Yamada T, Nishiyama Y, Arai T, Makimura K
  • Journal Title: Med Mycol Volume: 54 Pages: 207-18
  • DOI: 10.1093/mmy/myv088
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Dermatophytosis due to Microsporum incurvatum: notification and identification of a neglected pathogenic species (2015)
  • Author(s): Rezaei-Matehkolaei A, Makimura K, Graser Y, Seyedmousavi S, Abastabar M, Rafiei A, Zhan P, Ronagh A, Jafarpour S
  • Journal Title: Mycopathologia Volume: 181 Pages: 107-13
  • DOI: 10.1007/s11046-015-9946-6
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Microbes and crewed space habitat (2015)
  • Author(s): Yamaguchi N, Nasu M
  • Journal Title: J Dis Res Volume: 10 Pages: 1022-4
• [Journal Article] Microbial observatory research in the International Space Station and Japanese Experiment Module "Kibo" (2015)
  • Author(s): Shirakawa M, Tanigaki F, Yamazaki T
  • Journal Title: J Dis Res Volume: 10 Pages: 1025-30
• [Journal Article] Significance of changes in the skin fungal microbiomes of astronauts staying on the International Space Station (2015)
  • Author(s): Sugita T, Cho O
  • Journal Title: J Dis Res Volume: 10 Pages: 1031-4
• [Journal Article] Bacterial Monitoring in the International Space Station (2015)
  • Author(s): Ichijo T, Yamaguchi N, nasu M
  • Journal Title: J Dis Res Volume: 10 Pages: 1035-9
• [Presentation] Molecular physiology in C. elegans body-wall muscles (2018)
  • Author(s): Higashitani A
  • Organizer: INDO-JAPAN Conference: Epigenetics, Human Microbiomes and Disease
  • Int'l Joint Research / Invited
• [Presentation] Development of 3D clinostat synchronized irradiation system for simulating space conditions (2018)
  • Author(s): Ikeda H, Souda H, Puspitasari A, Held KD, Hidema J, Yoshida Y, Kanai T, Hada M, Saganti P, Takahashi A
  • Organizer: 2018 NASA Human Research Program Investigators' Workshop
  • Int'l Joint Research
• [Presentation] Effects of air velocities on photosynthesis, transpiration, and water use efficiencies of a plant canopy and single leaves (2018)
  • Author(s): Kitaya Y, Shibuya T, Tsuruyama J
  • Organizer: International Symposium on Agricultural Meteorology (ISAM2018)
  • Int'l Joint Research
• [Presentation] Decoding the Molecular Strategy of Radiotolerance in Extremotolerant Animal Model, Tardigrades (2018)
  • Author(s): Kunieda T
  • Organizer: The Endocrine Society’s 100th Annual Meeting
  • Int'l Joint Research / Invited
• [Presentation] ディープラーニングによる脳波/筋電データを用いたマウスの睡眠ステージ判定 (2018)
  • Author(s): 山部 剛士、堀江 和正、塩川 浩昭、柳沢 正史、北川 博之
  • Organizer: 第10回データ工学と情報マネジメントに関するフォーラム(DEIM2018)
• [Presentation] 宇宙環境に対する植物反応解析のための模擬太陽光人工光源ユニットの開発 (2018)
  • Author(s): 日出間純, 北宅善昭, 髙橋昭久
  • Organizer: 第32回宇宙環境利用シンポジウム
• [Presentation] 宇宙居住と宇宙放射線研究 (2018)
  • Author(s): 髙橋昭久
  • Organizer: 第32回宇宙環境利用シンポジウム
  • Invited
• [Presentation] Studies on skeletal muscle regeneration and atrophy; what zebrafish experienced in a space tour (2017)
  • Author(s): Sehara-Fujisawa A
  • Organizer: 第12回東京大学医科学研究所ネットワーク国際シンポジウム
  • Int'l Joint Research / Invited
• [Presentation] Muscle molecular physiology in spaceflown C. elegan (2017)
  • Author(s): Higashitani A
  • Organizer: 14th Japan-Korea Joint Seminar on Space Environment Utilization Research
  • Int'l Joint Research
• [Presentation] A heatstroke model in C. elegans (2017)
  • Author(s): Momma K, Homma T, Isaka R, Sudevan S, Higashitani A
  • Organizer: The 21th International C. elegans Meeting
  • Int'l Joint Research
• [Presentation] Mitochondrial dysfunction mediated ECM degradation in C. elegans (2017)
  • Author(s): Sudevan S, Takiura M, Kubota Y, Higashitani N, Higashitani A
  • Organizer: The 21th International C. elegans Meeting
  • Int'l Joint Research
• [Presentation] Forward genetic analysis of sleep in mice (2017)
  • Author(s): Hiromasa Funato, Masashi Yanagisawa
  • Organizer: Keystone symposia "State of the Brain"
  • Int'l Joint Research
• [Presentation] Hypothalamic Ptf1a is required for sexual differentiation of the brain and behavior (2017)
  • Author(s): Tomoyuki Fujiyama, Satoshi Miyashita, Yousuke Tsuneoka, Mai Nagaoka, Miyo Kakizaki, Satomi Kanno, Yukiko Ishikawa, Yoshiya Kawaguchi, Yuchio Yanagawa, Mark A. Magnuson, Yo-ichi Nabeshima, Masashi Yanagisawa, Hiromasa Funato, Mikio Hoshino
  • Organizer: Neuroscience 2017
  • Int'l Joint Research
• [Presentation] Incidence of circadian misalignment during stay in low-level light environments (2017)
  • Author(s): Shingo Kitamura, Akiko Hida, Michitaka Yoshimura, Kazuo Mishima
  • Organizer: 2017 Symposium of the Society for the Study of Human Biology & International Association of Physiological Anthropology
  • Int'l Joint Research
• [Presentation] Design and synthesis of orexin receptor selective ligands (2017)
  • Author(s): Nagase H
  • Organizer: 26th French-Japanese Symposium on Medicinal and Fine Chemistry
  • Int'l Joint Research / Invited
• [Presentation] Long term effects of noisy galvanic vestibular stimulation on postural stability in elderly adult (2017)
  • Author(s): Iwasaki S
  • Organizer: IFOS ENT World Congress
  • Int'l Joint Research
• [Presentation] Novel transgenic rat lines regulating the neuronal activity in rat vasopressin neuron by using Optogenetics and DREADDs technology (2017)
  • Author(s): Yoshimura M
  • Organizer: International Society for Autonomic Neuroscience (ISAN)
  • Int'l Joint Research
• [Presentation] C1 neurons mediate a stress-induced protection of renal ischemia/reperfusion injury (2017)
  • Author(s): Abe C
  • Organizer: International Society for Autonomic Neuroscience (ISAN)
  • Int'l Joint Research
• [Presentation] Comprehensive gene expression analysis of human fibroblasts after combined exposure to microgravity and heavy-ions for simulating space conditions (2017)
  • Author(s): Ikeda I, Muratani M, Puspitasari A, Held KD, Hidema J, Yoshida Y, Takahashi A
  • Organizer: The 7th International Society of Radiation Neurobiology Conference
  • Int'l Joint Research
• [Presentation] Effects of the combination of CO2 and cephalad fluid shift on dynamic cerebral autoregulation (2017)
  • Author(s): Kurazumi T, Iwasaki K, Ogawa Y, Yanagida R, Aoki K
  • Organizer: 16th International Symposium on Intracranial Pressure and Neuromonitoring in conjunction with the 6th Annual Meeting of the Cerebral Autoregulation Research Network
  • Int'l Joint Research
• [Presentation] Role of mechanosensitive channel in gravity sensing and responses against environmental stresses in ISS (2017)
  • Author(s): Furuichi T, Nakano M and Tatsumi H
  • Organizer: Plant Signaling and Behavior 2017 (PSB2017)
  • Int'l Joint Research
• [Presentation] Effects of long term running training on the responsiveness of genes to unloading in hindlimb muscles of rats (2017)
  • Author(s): Kawano F., Nakamura K., Ohsawa I., Masuzawa R., Konno R., Watanabe A., and Nakata K
  • Organizer: Cell Symposia: Exercise Metabolism
  • Int'l Joint Research
• [Presentation] Response of Pol II distribution to acute running in fast- and slow-twitch muscles of adult rats (2017)
  • Author(s): Masuzawa R., Tagawa D., Takemoto K., Ohsawa I., Watanabe A., and Kawano F
  • Organizer: Cell Symposia: Exercise Metabolism
  • Int'l Joint Research
• [Presentation] Workshop: Skin fungal microbiome of patients with Malassezia-related skin disease (2017)
  • Author(s): Sugita T, Cho O
  • Organizer: 15th International Congress of Mycology and Eukaryotic Microbiology
  • Int'l Joint Research
• [Presentation] Gene expression profile changes of human fibroblasts using device to synchronize carbon-ion irradiation and simulated microgravity (2017)
  • Author(s): Ikeda H, Muratani M, Puspitasari A, Held KD, Hidema J, Yoshida Y, Takahashi A
  • Organizer: ISSRPRT2017
  • Int'l Joint Research
• [Presentation] RNAseq profiling to analyze the combined effects on radiation under simulated microgravity for space biosciences (2017)
  • Author(s): Takahashi A, Ikeda H, Muratani M, Puspitasari A, Held KD, Hidema J, Yoshida Y
  • Organizer: 63rd Annual RRS Meeting
  • Int'l Joint Research
• [Presentation] Biological significance of CPD photolyase in rice grown under natural sunlight: UVB sensitivity and gene expression and subcellular localization of CPD photolyase (2017)
  • Author(s): Hidema J
  • Organizer: Symposium entitled DNA repair since the Nobel Prize, European Society of Photobiology Congress
  • Int'l Joint Research / Invited
• [Presentation] Effects of simulated microgravity on UV resistance of plants (2017)
  • Author(s): Hidema J
  • Organizer: 14th Japan-Korea Joint Seminar on Space Environment Utilization Research
  • Int'l Joint Research / Invited
• [Presentation] Acute effects of low-LET and high-LET radiation on fear memory formation and its underlying mechanisms (2017)
  • Author(s): Puspitasari A, Koganezawa N, Shirao T, Kojima N, Held KD, Takahashi A, Nakano T
  • Organizer: ISSRPRT2017
  • Int'l Joint Research
• [Presentation] How can we overcome tumor radioresistance; lessons from hypoxia biology (2017)
  • Author(s): Harada H
  • Organizer: 1st International Symposium on Radiation Therapeutics and Biology (isRTB-2017)
  • Int'l Joint Research / Invited
• [Presentation] The Causal Relationship between DNA Damage Induction in Bovine Lymphocytes and the Fukushima Nuclear Power Plant Accident (2017)
  • Author(s): Nakamura AJ, Suzuki M, Redon CE, Kuwahara Y, Yamashiro H, Abe Y, Takahashi S, Fukuda T, Isogai E, Bonner WM, Fukumoto M
  • Organizer: 2nd International Symposium of Quantum Beam Science at Ibaraki University
  • Int'l Joint Research
• [Presentation] Relative Effectiveness of Heavy Ion Irradiations from Accelerated Iron-56 Particles for Induction of Genotoxicity in the Hematopoietic System in Mice: Hematological Abnormality in the Peripheral Blood and Residual Damage in the Bone Marrow Erythrocytes (Part II) (2017)
  • Author(s): B.Wang, K.Tanaka, T.Katsube, Y.Ninomiya, H.Hirakawa, C.Liu, K.Maruyama, G.Vares, T.Nakajima, A.Nagamatsu, A.Fujimori, M.Nenoi
  • Organizer: The 63rd Annual International Meeting, Radiation Research Society
  • Int'l Joint Research
• [Presentation] FISH analysis of chromosomal aberrations in mouse splenocytes following total body irradiation with heavy ions (iron-56 ions) and X-rays (2017)
  • Author(s): T.Katsube, B.Wang, K.Tanaka, Y.Ninomiya, H.Hirakawa, C.Liu, K.Maruyama, G.Vares, T.Nakajima, A.Nagamatsu, A.Fujimori, M.Nenoi
  • Organizer: The 63rd Annual International Meeting, Radiation Research Society
  • Int'l Joint Research
• [Presentation] Evaluation of novel radiaoprotective drug and development of DNA damage monitoring micro-nano device for triage of radiation exposure (2017)
  • Author(s): Nakamura AJ, Tetsuka R, Takahashi K, Tamura T, Suzuki T and Hirayama R
  • Organizer: The 63rd Annual International Meeting, Radiation Research Society
  • Int'l Joint Research
• [Presentation] Hypoxia and radioresistance (2017)
  • Author(s): Harada H
  • Organizer: The 3rd Bordeaux Symposium
  • Int'l Joint Research
• [Presentation] Comparative exploration of biomarkers in mice exposed to X-ray or Fe-ion radiation (2017)
  • Author(s): T. Nakajima, G. Vares, Y. Ninomiya, B. Wang, T. Katsube, K. Tanaka, C. Liu, H.Hirakawa, K. Maruyama, A. Fujimori
  • Organizer: The 56th Annual Conference of the particle thrapy co-operative group
  • Int'l Joint Research
• [Presentation] Visualization of In Vivo DNA damage responses to galactic cosmic radiation (2017)
  • Author(s): A.Fujimori, H.Hirakawa, and L.Cuihua
  • Organizer: The 5th International Symposium on Space Radiation and Particle Radiotherapy
  • Int'l Joint Research
• [Presentation] Radiation-induced DNA-protein cross-links: mechanisms and significance (2017)
  • Author(s): Ide H
  • Organizer: US-Japan DNA Repair Meeting
  • Int'l Joint Research / Invited
• [Presentation] Closed plant factory in controlled ecological life support system in space (2017)
  • Author(s): Kitaya Y, Hirai H, Endo R, Shibuya T
  • Organizer: 2017 World Workshop of International Commission of Agricultural and Biosystems Engineering
  • Int'l Joint Research
• [Presentation] Decoding of unique strategy for extreme tolerance in tardigrades (2017)
  • Author(s): Kunieda T
  • Organizer: Vienna Biocenter Seminar
  • Int'l Joint Research / Invited
• [Presentation] 筋維持・萎縮機構の研究：宇宙から学ぶこと (2017)
  • Author(s): 瀬原淳子
  • Organizer: 第6回実験動物科学シンポジウム-宇宙における動物実験-
  • Invited
• [Presentation] 宇宙滞在が骨格筋に及ぼす影響―重力負荷減少だけではなさそう？ (2017)
  • Author(s): 佐藤文規、Choi Minyong、王梓，岩瀬海里、今村聖実、堀内映美、内田智子、小林純也、高橋昭久、菅野純夫、鈴木穣、川上浩一、瀬原淳子
  • Organizer: 日本宇宙生物科学会第３１回大会
• [Presentation] 筋タイプ特有のエピゲノムと遺伝子転写応答 (2017)
  • Author(s): 河野史倫
  • Organizer: Consortium of Biological Sciences 2017
• [Presentation] 14日間の閉鎖環境が循環調節機能に与える影響 (2017)
  • Author(s): 加藤智一、柳田亮、田子智晴、倉住拓弥、井上夏彦、鈴木豪、小川洋二郎、古川聡、岩崎賢一
  • Organizer: 第63回日本宇宙航空環境医学会大会
• [Presentation] 宇宙での身体の変化と宇宙医学（シンポジウム：宇宙環境における生体影響） (2017)
  • Author(s): 古川聡
  • Organizer: 第65回日本職業・災害医学会学術大会
  • Invited
• [Presentation] 宇宙環境における循環調節の変化（シンポジウム：宇宙環境における生体影響） (2017)
  • Author(s): 岩崎賢一
  • Organizer: 第65回日本職業・災害医学会学術大会
  • Invited
• [Presentation] ラット足底筋のヒストン修飾を変化させる運動条件の検討 (2017)
  • Author(s): 大沢育未、河野史倫
  • Organizer: 第72回日本体力医学会大会
• [Presentation] PGC-1遺伝子座における遅筋・速筋のエピゲノム相違と急性走運動に対する特異的転写制御 (2017)
  • Author(s): 増澤諒、大沢育未、田川大智、竹元玖乙、山田達也、河野史倫
  • Organizer: 第72回日本体力医学会大会
• [Presentation] 走運動歴を持つラットの後肢筋における廃用性萎縮応答の変化 (2017)
  • Author(s): 河野史倫、中村圭介、大沢育未、金野遼太朗、増澤諒
  • Organizer: 第72回日本体力医学会大会
• [Presentation] 経皮的ノイズ前庭電気刺激が歩行に及ぼす影響：両側前庭障害症例の検討 (2017)
  • Author(s): 岩﨑真一，藤本千里，木下淳，江上直也，鴨頭輝，牛尾宗貴，菅澤恵子，山岨達也
  • Organizer: 第117回日本耳鼻咽喉科学会総会
• [Presentation] 低周波騒音曝露が誘発する平衡感覚障害の解析 (2017)
  • Author(s): 大神信孝
  • Organizer: 第86回日本衛生学会学術総会
• [Presentation] ヒトの糖尿病においてβ細胞脱分化はβ細胞不全に関連する (2017)
  • Author(s): 椎木幾久子、田部勝也、幡中雅行、近藤 学、西村 渉、木村徳広、池田栄二、水上浩哉、佐藤吉彦、駒津光久、谷澤幸生
  • Organizer: 第60回日本糖尿病学会年次学術集
• [Presentation] シンポジウム：大気と宇宙微生物生態学の幕開け、国際宇宙ステーション与圧部の微生物モニタリングと群集構造 ---宇宙居住と地上応用--- (2017)
  • Author(s): 那須正夫、一條知昭、杉田隆
  • Organizer: 環境微生物系学会合同大会2017
• [Presentation] 新学術領域研究「宇宙に生きる」 (2017)
  • Author(s): 古川聡
  • Organizer: ConBio2017
  • Invited
• [Presentation] 植物の太陽粒子線障害に微小重力環境が及ぼす影響解析 (2017)
  • Author(s): 日出間純
  • Organizer: ConBio2017
  • Invited
• [Presentation] 搭載凍結受精卵から発生するマウスを用いた宇宙放射線の影響解析 (2017)
  • Author(s): 柿沼志津子、鶴岡千鶴、塚本智史、鬼頭靖司、小久保年章、和田彩子、島田義也、矢野幸子、鈴木智美、東端晃、多田基紀、鈴木ひろみ、嶋津徹
  • Organizer: 日本放射線影響学会第60回大会
  • Invited
• [Presentation] ISS搭載凍結受精卵から発生するマウスの宇宙放射線影響の解析Ⅱ (2017)
  • Author(s): 鶴岡千鶴、柿沼志津子、塚本智史、鬼頭靖司、小久保年章、和田彩子、島田義也、矢野幸子、鈴木智美、東端晃、多田紀、鈴木ひろみ、嶋津徹
  • Organizer: 日本宇宙生物科学会第31回大会
• [Presentation] 宇宙環境における宿主-病原体の相互作用の解析に向けた感染モデルの構築 (2017)
  • Author(s): 浅岡 洋一, 荻野 英賢, 白井 睦訓
  • Organizer: 第70回日本細菌学会中国・四国支部総会
• [Presentation] ヒト細胞の高LET放射線に対する応答におけるArtemisとXRCC4の機能 (2017)
  • Author(s): 勝部孝則、 劉 強、 謝 、王 冰
  • Organizer: 第40回日本分子生物学会年会・第90回日本生化学会大会
• [Presentation] 放射線が誘発するDNA-タンパク質クロスリンク損傷の解析 (2017)
  • Author(s): 松坂智幸，西村夕紀，徐徐，中野敏彰，平山亮一，鵜澤玲子，井出博
  • Organizer: 第40回日本分子生物学会年会
• [Presentation] DNA-タンパク質クロスリンク：検出と生物影響 (2017)
  • Author(s): 井出博
  • Organizer: 日本環境変異原学会第46回大会
• [Presentation] 酸化剤が誘発するDNA-タンパク質クロスリンク損傷の検出 (2017)
  • Author(s): 瀬畑敬文，久保山政弥，徐徐，Amir Salem，Mahmoud Shoulkamy，井出博，中野敏彰
  • Organizer: 第39回日本分子生物学会年会
• [Presentation] 放射線が誘発するクラスターDNA損傷の性状解析 (2017)
  • Author(s): 徐徐，金本僚太，松坂智幸，中野敏彰，平山亮一，鵜澤玲子，井出博
  • Organizer: 日本放射線影響学会第60回大会
• [Presentation] 宇宙滞在における放射線防護のためのバイオマーカーと防護剤の探索 (2017)
  • Author(s): 中島徹夫
  • Organizer: 日本放射線影響学会第60回大会
• [Presentation] X線照射後の生体応答に対する低酸素環境の役割に関する研究 (2017)
  • Author(s): 劉 翠華, 平川博一, 藤森 亮, 平山亮一
  • Organizer: 日本放射線影響学会第60回大会
• [Presentation] Piceatannolによる放射線防護効果の検討 (2017)
  • Author(s): 手塚諒哉、平山亮一、下川卓志、中村麻子
  • Organizer: 日本放射線影響学会第60回大会
• [Presentation] PDMSチップを用いたDNA損傷モニタリングシステムの開発 (2017)
  • Author(s): 高橋健太、田村隆大、鈴木孝明、中村麻子
  • Organizer: 日本放射線影響学会第60回大会
• [Presentation] 抗酸化剤による高LET放射線に対するDNA損傷防護効果の検討 (2017)
  • Author(s): 中村麻子、手塚諒哉、笹谷めぐみ、志村勉、神谷研二
  • Organizer: 日本宇宙生物科学会第31回大会
• [Presentation] 航空機放物飛行実験による微小重力下での植物栽培システム水循環 (2017)
  • Author(s): 北宅善昭、遠藤良輔、髙橋昭久、日出間純、橋本博文、稲富裕光
  • Organizer: 第32回宇宙環境利用シンポジウム
• [Presentation] 疑似宇宙環境における基本的生命現象の可視化 (2017)
  • Author(s): 沢野朝子
  • Organizer: 日本宇宙生物科学会第31回大会
• [Presentation] ベールを脱ぎ始めたクマムシの極限環境耐性メカニズム (2017)
  • Author(s): 國枝武和、橋本拓磨、堀川大樹、近藤小雪、田中冴、柴原礼良、桑原宏和、秦裕子、尾山大明、榎本敦、宮川清、原雄一郎、横堀伸一、小原雄治、藤山秋佐夫、久保健雄、荒川和晴、片山俊明
  • Organizer: ConBio2017
  • Invited
• [Presentation] 動物の極限環境耐性から生命の本質を探 (2017)
  • Author(s): 國枝武和
  • Organizer: 未来へのバイオ技術勉強会-超絶生物イノベーション
  • Invited
• [Presentation] 養育者の対乳幼児発話に関与する神経基盤の検討 (2017)
  • Author(s): 笠羽涼子, 島田浩二, 友田明美
  • Organizer: 第118回日本小児精神神経学会
• [Presentation] 養育者の抑うつ気分が社会的認知とその脳機能に及ぼす影響に関する実験的研究: 養育者支援によって子育て困難を低減するシステムの構築に向けた取り組み (2017)
  • Author(s): 島田浩二, 笠羽涼子, 藤澤隆史, 榊原信子, 滝口慎一郎, 友田明美
  • Organizer: 第118回日本小児精神神経学会
• [Presentation] Roles of Meltrin β/ADAM19 in development of the heart (2016)
  • Author(s): Atsuko Sehara-Fujisawa
  • Organizer: Swiss-Kyoto Joint Symposium of Life Science 2016
  • Place of Presentation: Kyoto, Japan
  • Int'l Joint Research / Invited
• [Presentation] Introduction of a project study entitled “Modification Effect from Chronic Restraint-Induced Stress on Mouse Radiosusceptibility (2016)
  • Author(s): Wang B and Nenoi M et al.
  • Organizer: Workshop of Radiation Medicine and Protection
  • Place of Presentation: Tianjin, P.R. China
  • Int'l Joint Research / Invited
• [Presentation] The potential of medaka fish to uncover mechanisms of osteoclastogenesis (2016)
  • Author(s): Chatani M
  • Organizer: 13th Meeting of Bone Biology Forum
  • Place of Presentation: Chiba, Japan
  • Int'l Joint Research / Invited
• [Presentation] Effects of chronic restraint-induced stress on radiation-induced chromosomal aberrations in mouse splenocytes (2016)
  • Author(s): Katsube T and Nenoi M et al.
  • Organizer: Workshop of Radiation Medicine and Protection
  • Place of Presentation: Tianjin, P.R. China.
  • Int'l Joint Research
• [Presentation] Effect of noisy galvanic vestibular stimulation on locomotion in patients with bilateral vestibular dysfunction (2016)
  • Author(s): Iwasaki S and Morita H et al.
  • Organizer: 2016 Annual CORLAS Meeting
  • Place of Presentation: Bordeaux, France
  • Int'l Joint Research
• [Presentation] VEMP (Basic)-The neural basis of vestibular evoked myogenic potentials. Characteristics of oVEMPs in response to air-conducted sound and bone-conducted vibration (2016)
  • Author(s): Iwasaki S
  • Organizer: 29th Barany Society Meeting
  • Place of Presentation: Seoul, Korea
  • Int'l Joint Research
• [Presentation] 年をとると筋肉が衰えるのは何故？-再生医学から宇宙生物学まで- (2016)
  • Author(s): 瀬原淳子
  • Organizer: 京都大学再生医科学研究所 第11回公開講演会
  • Place of Presentation: 京都
  • Invited
• [Presentation] 幹細胞の増殖・分化制御機構のプロテアーゼ制御 (2016)
  • Author(s): 瀬原淳子
  • Organizer: 第21回 日本病態プロテアーゼ学会
  • Place of Presentation: 大阪
  • Invited
• [Presentation] 遺伝子改変メダカから考える骨代謝 (2016)
  • Author(s): 茶谷昌宏
  • Organizer: 第15回松本ボーンフォーラム
  • Place of Presentation: 松本
  • Invited
• [Presentation] 低周波騒音曝露が誘発する平衡感覚障害の解析 (2016)
  • Author(s): 大神信孝
  • Organizer: 第86回日本衛生学会学術総会
  • Place of Presentation: 旭川
  • Invited
• [Presentation] オレキシン受容体作動薬：創薬への展望 (2016)
  • Author(s): 長瀬博
  • Organizer: 日本睡眠学会第41回定期学術集会
  • Place of Presentation: 東京
• [Presentation] 宇宙での脳循環変化の研究 (2016)
  • Author(s): 岩崎賢一
  • Organizer: 第29回宇宙生物科学会大会
  • Place of Presentation: 東京
• [Presentation] エピジェネティクスと骨格筋の適応性変化 (2016)
  • Author(s): 河野史倫 他
  • Organizer: 第24回日本運動生理学会大会
  • Place of Presentation: 熊本
• [Presentation] 遺伝子改変メダカを用いた骨研究 (2016)
  • Author(s): 茶谷昌宏 他
  • Organizer: 第330回昭和大学学士会例会
  • Place of Presentation: 東京
• [Presentation] 経皮的ノイズ前庭電気刺激が歩行に及ぼす影響：両側前庭障害症例の検討 (2016)
  • Author(s): 岩﨑真一 他
  • Organizer: 第117回日本耳鼻咽喉科学会総会
  • Place of Presentation: 名古屋
• [Presentation] 閉鎖環境ストレス下におけるNIRS（光トポグラフィー）測定の試み (2016)
  • Author(s): 笹原信一朗
  • Organizer: 第26 回体力・栄養・免疫学会大会
  • Place of Presentation: 長崎
• [Presentation] 擬似微小重力環境における高精度重粒子線同期照射システムの開発 (2016)
  • Author(s): 高橋昭久 他
  • Organizer: 第62回日本宇宙航空環境医学会大会・日本宇宙生物科学会第30回大会
  • Place of Presentation: 名古屋
  • Year and Date: 2016-10-13
• [Presentation] 植物の重力感知・適応におけるカルシウムシグナルの役割 (2016)
  • Author(s): 古市卓也 他
  • Organizer: 第62回日本宇宙航空環境医学会大会・日本宇宙生物科学会第30回大会
  • Place of Presentation: 名古屋
  • Year and Date: 2016-10-13
• [Presentation] ISSを利用した植物の太陽粒子線による障害とその修復機構に微小重力環境が及ぼす影響解析 (2016)
  • Author(s): 日出間純 他
  • Organizer: 第62回日本宇宙航空環境医学会大会・日本宇宙生物科学会第30回大会
  • Place of Presentation: 名古屋
  • Year and Date: 2016-10-13
• [Presentation] 閉鎖環境ストレス下におけるストレス対処力の指標としてのSOC(Sence of Coherence)連続測定の試み (2016)
  • Author(s): 笹原信一朗
  • Organizer: 第62回日本宇宙航空環境医学会大会・日本宇宙生物科学会第30回大会
  • Place of Presentation: 名古屋
  • Year and Date: 2016-10-13
• [Presentation] c-fmsトランスジェニックメダカとc-fmsノックアウトメダカの駆使により明らかになった生体内破骨前駆細胞の動態 (2016)
  • Author(s): 茶谷昌宏 他
  • Organizer: 第34回日本骨代謝学会学術集会
  • Place of Presentation: 大阪
  • Year and Date: 2016-07-20
• [Presentation] Space Flight Experiment: Temporal Changes in the Skin Fungal Microbiomes of Astronauts in the International Space Station (2016)
  • Author(s): Sugita T et al.
  • Organizer: 30th International Symposium on Space Technology and Science
  • Place of Presentation: Kobe, Japan
  • Year and Date: 2016-07-04
  • Int'l Joint Research
• [Presentation] Effects of the combination of CO2 and cephalad fluid shift on dynamic cerebral autoregulation (2016)
  • Author(s): Kurazumi T and Iwasaki K et al.
  • Organizer: 16th International Symposium on Intracranial Pressure and Neuromonitoring in conjunction with the 6th Annual Meeting of the Cerebral Autoregulation Research Network
  • Place of Presentation: Cambridge, MA, USA
  • Year and Date: 2016-06-28
  • Int'l Joint Research
• [Presentation] 宇宙微生物学への招待～国際宇宙ステーションにおけるgene ecology～ (2016)
  • Author(s): 那須正夫
  • Organizer: 第14回日本予防医学会学術総会
  • Place of Presentation: 東京
  • Year and Date: 2016-06-18
  • Invited
• [Presentation] 宇宙で過ごした魚の骨格筋はやせるのか？ -宇宙実験の結果より- (2016)
  • Author(s): 佐藤文規
  • Organizer: 第14回日本予防医学会学術総会
  • Place of Presentation: 東京
  • Year and Date: 2016-06-18
• [Presentation] 国際宇宙ステーション「きぼう」における細菌モニタリング (2016)
  • Author(s): 一條知昭
  • Organizer: 第14回日本予防医学会学術総会
  • Place of Presentation: 東京
  • Year and Date: 2016-06-18
• [Presentation] 有人閉鎖環境滞在研究におけるNIRS活用の試み (2016)
  • Author(s): 村井正
  • Organizer: 第14回日本予防医学会学術総会
  • Place of Presentation: 東京
  • Year and Date: 2016-06-18
• [Presentation] Symposium Bone I Biomarker in skeletomusucular system: Muscle-derived factor affecting bone metabolism (2016)
  • Author(s): Kaji H
  • Organizer: The 4th Seoul International Congress of Endocrinology and Metabolism (SICEM 2016)
  • Place of Presentation: Seoul, Korea
  • Year and Date: 2016-04-28
  • Int'l Joint Research
• [Presentation] 新たな視点で環境中の微生物をとらえる ―家庭から宇宙居住まで― (2016)
  • Author(s): 那須正夫
  • Organizer: 第33回空気清浄とコンタミネーションコントロール研究大会
  • Place of Presentation: 東京
  • Year and Date: 2016-04-19
• [Presentation] Design and synthesis of novel ligands of opioid receptors (2015)
  • Author(s): Nagase H
  • Organizer: Pacifichem
  • Place of Presentation: Honolulu, HI, USA
  • Year and Date: 2015-12-17
  • Int'l Joint Research / Invited
• [Presentation] "Hope" from the International Space Station (2015)
  • Author(s): Furukawa S
  • Organizer: First International Symposium on Space Science of High Quality Protein Crystallization Technology
  • Place of Presentation: Tokyo, JAPAN
  • Year and Date: 2015-10-26
  • Int'l Joint Research / Invited
• [Presentation] 長期宇宙滞在時に解決すべき医学的課題 (2015)
  • Author(s): 古川聡
  • Organizer: 第29回宇宙生物科学会大会
  • Place of Presentation: 東京
  • Year and Date: 2015-09-27
  • Invited
• [Presentation] Roles of ADAM8 in elimination of injured muscle fibers prior to skeletal muscle regeneration (2015)
  • Author(s): Sehara-Fujisawa A
  • Organizer: 44th European Muscle Conference
  • Place of Presentation: Warsaw, POLAND
  • Year and Date: 2015-09-21
  • Int'l Joint Research / Invited
• [Presentation] Design and synthesis of novel delta opioid agonists and their pharmacologies (2015)
  • Author(s): Nagase H
  • Organizer: Drug Discovery & Therapy World Congress
  • Place of Presentation: Boston, MA, USA
  • Year and Date: 2015-07-23
  • Int'l Joint Research / Invited
• [Book] The Lipid, vol.27「Ⅲ.サルコぺニアの予防と治療、1.筋衛星細胞活性化による骨格筋再生」 (2016)
  • Author(s): 瀬原淳子
  • Total Pages: 6
  • Publisher: メディカルレビュー社
• [Book] Arch Pharm Chem Life Sci「Synthesis of novel triplets with a 1,3,5-trioxazatriquinane skeleton and their pharmacologies for opioid receptors」 (2015)
  • Author(s): Nagase H, Katsunuma N
  • Total Pages: 15
  • Publisher: Wiley
• [Book] Orexin and Sleep: Molecular, Functional and Clinical Aspects「Orexin and Metabolism」 (2015)
  • Author(s): Funato H
  • Total Pages: 18
  • Publisher: Springer
• [Book] 平成27年度日本薬学会医薬化学部会賞を受賞し、Med Chem Newsに掲載「低分子オレキシン受容体アゴニストの創製」 (2015)
  • Author(s): 斉藤毅、長瀬博
  • Total Pages: 7
  • Publisher: 日本薬学会
• [Book] メカノバイオロジー：細胞が力を感じ応答する仕組み (2015)
  • Author(s): 曽我部正博（編集）
  • Total Pages: 332
  • Publisher: 化学同人
• [Book] 日本薬学会誌ファルマシア「オピニオン：メカノバイオロジーの可能性」 (2015)
  • Author(s): 曽我部正博
  • Total Pages: 3
  • Publisher: 日本薬学会
• [Book] 日本生物物理学会誌生物物理「アクチン線維は張力を感じ、コフィリンとの相互作用を介して細胞骨格の動態を制御するメカノセンサーである」 (2015)
  • Author(s): 辰巳仁史、早川公英、曽我部正博
  • Total Pages: 5
  • Publisher: 日本生物物理学会
• [Book] 血管医学「発展するメカノセンシング研究」 (2015)
  • Author(s): 曽我部正博
  • Total Pages: 13
  • Publisher: メディカルレビュー社
• [Book] JOHNS「起立性調節障害に自律神経はどう関与するか？」 (2015)
  • Author(s): 森田啓之
  • Total Pages: 4
  • Publisher: 東京医学社
• [Book] PROGRESS IN MEDICINE「フレイルと骨粗鬆症の関連」 (2015)
  • Author(s): 梶博史
  • Total Pages: 4
  • Publisher: ライフサイエンス
• [Book] 循環制御「長期宇宙滞在時に解決すべき医学的課題～循環制御関連を中心に～」 (2015)
  • Author(s): 古川聡
  • Total Pages: 3
  • Publisher: 日本循環制御医学会
• [Remarks] 宇宙に生きるHP
  • URL: http://living-in-space.jp/
• [Remarks] 宇宙に生きるHP 英語版
  • URL: http://living-in-space.jp/en/
• [Remarks] 宇宙に生きる 宇宙からひも解く新たな生命制御機構の統合的理解
  • URL: http://living-in-space.jp/
• [Funded Workshop] International Symposium on LIVING IN SPACE (2017)
  • Place of Presentation: Tokyo