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Creation and Promotion of Willdynamics

Administrative Group

Project AreaCreation and Promotion of the Will-Dynamics
Project/Area Number 16H06400
Research Category

Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)

Allocation TypeSingle-year Grants
Review Section Complex systems
Research InstitutionUniversity of Tsukuba

Principal Investigator

Sakurai Takeshi  筑波大学, 医学医療系, 教授 (60251055)

Co-Investigator(Kenkyū-buntansha) 田中 あゆみ  同志社大学, 心理学部, 教授 (00373085)
浅川 明弘  鹿児島大学, 医歯学域医学系, 教授 (10452947)
藤原 広臨  京都大学, 医学研究科, 講師 (10599608)
尾内 康臣  浜松医科大学, 光尖端医学教育研究センター, 教授 (40436978)
征矢 英昭  筑波大学, 体育系, 教授 (50221346)
加藤 隆弘  九州大学, 大学病院, 講師 (70546465)
佐久間 英輔  名古屋市立大学, 医薬学総合研究院(医学), 講師 (90295585)
杉原 玄一  京都大学, 医学研究科, 助教 (70402261)
井上 浩一  名古屋市立大学, 大学院医学研究科, 准教授 (80345818)
鈴木 高志  高知工科大学, 共通教育教室, 准教授 (90725938)
乾 明夫  鹿児島大学, 医歯学域医学系, 教授 (80168418)
須藤 信行  九州大学, 医学(系)研究科(研究院), 准教授 (60304812)
榊 美知子  高知工科大学, 総合研究所, 客員准教授 (50748671)
植木 美乃  名古屋市立大学, 大学院医学研究科, 講師 (40467478)
入鹿山 容子  筑波大学, 人間総合科学研究科, 講師 (90312834)
犬束 歩  自治医科大学, 医学部, 助教 (30584776)
杉山 陽子 (矢崎陽子)  沖縄科学技術大学院大学, 臨界期の神経メカニズム研究ユニット, 准教授 (00317512)
牧之段 学  奈良県立医科大学, 医学部, 講師 (00510182)
Project Period (FY) 2016-06-30 – 2021-03-31
Project Status Completed (Fiscal Year 2020)
Budget Amount *help
¥353,080,000 (Direct Cost: ¥271,600,000、Indirect Cost: ¥81,480,000)
Fiscal Year 2020: ¥43,680,000 (Direct Cost: ¥33,600,000、Indirect Cost: ¥10,080,000)
Fiscal Year 2019: ¥43,680,000 (Direct Cost: ¥33,600,000、Indirect Cost: ¥10,080,000)
Fiscal Year 2018: ¥43,680,000 (Direct Cost: ¥33,600,000、Indirect Cost: ¥10,080,000)
Fiscal Year 2017: ¥43,680,000 (Direct Cost: ¥33,600,000、Indirect Cost: ¥10,080,000)
Fiscal Year 2016: ¥178,360,000 (Direct Cost: ¥137,200,000、Indirect Cost: ¥41,160,000)
Keywords意志力 / やる気 / 前頭前野 / 報酬系 / 覚醒 / ひきこもり / 教育心理 / スポーツ科学 / ドーパミン / 脳機能 / 内発的動機付け / 実行機能 / 実行系 / モチベーション / 環境 / 現代うつ / 脳・神経 / 精神医学 / 心理学 / 教育学
Outline of Final Research Achievements

The aim of this project is to elucidate the effects of social and internal environments on function of willpower, to search for environmental factors and brain molecules that serve as parameters of the dynamic equilibrium, and to establish measures to support the development of willpower by controlling these factors. This team provided comprehensive support for the promotion of such interdisciplinary and fusion research. In addition to research support activities, the group provided technical support for functional brain imaging and ultrastructural analysis. In addition, we provided support for young and female researchers, promoted joint research within the area, provided support for young researchers, and supported the promotion of research by each research group through exchanges and information exchange within and outside the area by holding presentations of results and symposia.

Academic Significance and Societal Importance of the Research Achievements

意志力を支える神経科学的メカニズムの解明、社会環境の変化や体内環境が意志力に与える影響の検討、意志力に問題を抱える青少年の社会教育学的および精神神経学的治療標的の探索、そして、運動、睡眠・食生活の是正などの生活指導によるそれら問題の解決を目的として活動してきた。人文、社会学的に定義づけられる『意志力(ウィルパワー)』を神経科学で解き明かすという、異分野融合とその社会還元に資する活動であり社会的意義は高いと考えられる。

Report

(6 results)
  • 2020 Annual Research Report   Final Research Report ( PDF )
  • 2019 Annual Research Report
  • 2018 Annual Research Report
  • 2017 Annual Research Report
  • 2016 Annual Research Report
  • Research Products

    (85 results)

All 2021 2020 2019 2018 2017 2016 Other

All Journal Article (58 results) (of which Int'l Joint Research: 21 results,  Peer Reviewed: 58 results,  Open Access: 37 results) Presentation (23 results) (of which Int'l Joint Research: 11 results,  Invited: 17 results) Book (3 results) Remarks (1 results)

  • [Journal Article] Corrigendum to “Do theta oscillations explain the somatosensory change detection mechanism?” Biol. Psychol. 143 (2019) April 103?1122021

    • Author(s)
      Zhang Zhilin、Guo Guoxin、Zhang Jian、Li Chunlin、Huang Qiang、Go Ritsu、Fukuyama Hidenao、Funahashi Shintaro、Yan Tianyi、Wu Jinglong
    • Journal Title

      Biological Psychology

      Volume: 159 Pages: 107995-107995

    • DOI

      10.1016/j.biopsycho.2020.107995

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Personality classification enhances blood metabolome analysis and biotyping for major depressive disorders: two-species investigation2021

    • Author(s)
      Setoyama Daiki、Yoshino Atsuo、Takamura Masahiro、Okada Go、Iwata Masaaki、Tsunetomi Kyohei、Ohgidani Masahiro、Kuwano Nobuki、Yoshimoto Junichiro、Okamoto Yasumasa、Yamawaki Shigeto、Kanba Shigenobu、Kang Dongchon、Kato Takahiro A.
    • Journal Title

      Journal of Affective Disorders

      Volume: 279 Pages: 20-30

    • DOI

      10.1016/j.jad.2020.09.118

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] A Discrete Glycinergic Neuronal Population in the Ventromedial Medulla That Induces Muscle Atonia during REM Sleep and Cataplexy in Mice2020

    • Author(s)
      Shuntaro Uchida, Shingo Soya, Yuki C Saito, Arisa Hirano, Keisuke Koga, Makoto Tsuda, Manabu Abe, Kenji Sakimura, Takeshi Sakurai
    • Journal Title

      journal of neuroscience

      Volume: 41 Issue: 7 Pages: 1582-1596

    • DOI

      10.1523/jneurosci.0688-20.2020

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] A discrete neuronal circuit induces a hibernation-like state in rodents2020

    • Author(s)
      Takahashi TM, Sunagawa GA, Soya S, Abe M, Sakurai K, Ishikawa K, Yanagisawa M, Hama H, Hasegawa E, Miyawaki A, Sakimura K, Takahashi M, Sakurai T.
    • Journal Title

      Nature

      Volume: - Issue: 7814 Pages: 109-114

    • DOI

      10.1038/s41586-020-2163-6

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Sparse Activity of Hippocampal Adult-Born Neurons during REM Sleep Is Necessary for Memory Consolidation2020

    • Author(s)
      Kumar D, Koyanagi I, Carrier-Ruiz A, Vergara P, Srinivasan S, Sugaya Y, Kasuya M, Yu TS, Vogt K, Muratani M, Ohnishi T, Singh S, Teixeira CM, Cherasse Y, Naoi T, Wang Y, Nondhalee P, Osman BAH, Kaneko N, Sawamoto K, Kernie SG, Sakurai T, McHugh TJ, Kano M, Yanagisawa M, Sakaguchi M
    • Journal Title

      Neuron

      Volume: 107 Issue: 3 Pages: 552

    • DOI

      10.1016/j.neuron.2020.05.008

    • URL

      https://localhost/en/publications/1d845831-3ee8-4cde-ae73-3f4d6bcffcb0

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Reply: A transvenous pressure gradient mechanism behind ventriculomegaly2020

    • Author(s)
      Aso Toshihiko、Sugihara Genichi、Murai Toshiya、Ubukata Shiho、Urayama Shin-ichi、Ueno Tsukasa、Fujimoto Gaku、Thuy Dinh Ha Duy、Fukuyama Hidenao、Ueda Keita
    • Journal Title

      Brain

      Volume: 143 Issue: 9 Pages: e75-e75

    • DOI

      10.1093/brain/awaa271

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Dynamic reconfiguration of functional brain networks supporting response inhibition in a stop-signal task2020

    • Author(s)
      Wang Bin、Hao Yaqing、Zhan Qionghui、Zhao Shuo、Li Dandan、Imtiaz Sumaira、Xiang Jie、Wu Jinglong、Fukuyama Hidenao、Yan Ting
    • Journal Title

      Brain Imaging and Behavior

      Volume: 14 Issue: 6 Pages: 2500-2511

    • DOI

      10.1007/s11682-019-00203-7

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed
  • [Journal Article] A venous mechanism of ventriculomegaly shared between traumatic brain injury and normal ageing2020

    • Author(s)
      Aso Toshihiko、Sugihara Genichi、Murai Toshiya、Ubukata Shiho、Urayama Shin-ichi、Ueno Tsukasa、Fujimoto Gaku、Thuy Dinh Ha Duy、Fukuyama Hidenao、Ueda Keita
    • Journal Title

      Brain

      Volume: 143 Issue: 6 Pages: 1843-1856

    • DOI

      10.1093/brain/awaa125

    • NAID

      120006844908

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Internet society, internet addiction, and pathological social withdrawal2020

    • Author(s)
      Kato Takahiro A.、Shinfuku Naotaka、Tateno Masaru
    • Journal Title

      Current Opinion in Psychiatry

      Volume: 33 Issue: 3 Pages: 264-270

    • DOI

      10.1097/yco.0000000000000601

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Social withdrawal in major depressive disorder: a case-control study of hikikomori in japan2020

    • Author(s)
      Teo Alan R.、Nelson Sarah、Strange Wynn、Kubo Hiroaki、Katsuki Ryoko、Kurahara Keita、Kanba Shigenobu、Kato Takahiro A.
    • Journal Title

      Journal of Affective Disorders

      Volume: 274 Pages: 1142-1146

    • DOI

      10.1016/j.jad.2020.06.011

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Forced social isolation due to COVID ‐19 and consequent mental health problems: Lessons from hikikomori2020

    • Author(s)
      Kato Takahiro A.、Sartorius Norman、Shinfuku Naotaka
    • Journal Title

      Psychiatry and Clinical Neurosciences

      Volume: 74 Issue: 9 Pages: 506-507

    • DOI

      10.1111/pcn.13112

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Forskolin rapidly enhances neuron‐like morphological change of directly induced‐neuronal cells from neurofibromatosis type 1 patients2020

    • Author(s)
      Sagata N
    • Journal Title

      Neuropsychopharmacology Reports

      Volume: 40 Issue: 4 Pages: 396-400

    • DOI

      10.1002/npr2.12144

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Autism spectrum conditions in hikikomori : A pilot case?control study2020

    • Author(s)
      Katsuki Ryoko、Tateno Masaru、Kubo Hiroaki、Kurahara Keita、Hayakawa Kohei、Kuwano Nobuki、Kanba Shigenobu、Kato Takahiro A.
    • Journal Title

      Psychiatry and Clinical Neurosciences

      Volume: 74 Issue: 12 Pages: 652-658

    • DOI

      10.1111/pcn.13154

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed
  • [Journal Article] In vivo mitochondrial and glycolytic impairments in patients with Alzheimer disease2020

    • Author(s)
      Terada T, Obi T, Bunai T, Matsudaira T, Yoshikawa E, Ando I, Futatsubashi M, Tsukada H, Ouchi Y
    • Journal Title

      Neurology

      Volume: in press Issue: 15 Pages: 1592-1604

    • DOI

      10.1212/wnl.0000000000009249

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Orchestrated ensemble activities constitute a hippocampal memory engram2019

    • Author(s)
      Khaled Ghandour, Noriaki Ohkawa, Chi Chung Alan Fung, Hirotaka Asai, Yoshito Saitoh, Takashi Takekawa, Reiko Okubo-Suzuki, Shingo Soya, Hirofumi Nishizono, Mina Matsuo, Makoto Osanai, Masaaki Sato, Masamichi Ohkura, Junichi Nakai, Yasunori Hayashi, Takeshi Sakurai, Takashi Kitamura, Tomoki Fukai & Kaoru Inokuchi
    • Journal Title

      Nature Communications

      Volume: 10 Issue: 1 Pages: 2637-2637

    • DOI

      10.1038/s41467-019-10683-2

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Glutamatergic neurons in the medial prefrontal cortex mediate the formation and retrieval of cocaine-associated memories in mice2019

    • Author(s)
      Zhang Tong、Yanagida Junko、Kamii Hironori、Wada Shintaro、Domoto Masaki、Sasase Hitoki、Deyama Satoshi、Takarada Takeshi、Hinoi Eiichi、Sakimura Kenji、Yamanaka Akihiro、Maejima Takashi、Mieda Michihiro、Sakurai Takeshi、Nishitani Naoya、Nagayasu Kazuki、Kaneko Shuji、Minami Masabumi、Kaneda Katsuyuki
    • Journal Title

      Addiction Biology

      Volume: 印刷中 Issue: 1 Pages: 1-11

    • DOI

      10.1111/adb.12723

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Endogenous dopamine release under transcranial direct-current stimulation governs enhanced attention: a study with positron emission tomography2019

    • Author(s)
      Fukai Mina、Bunai Tomoyasu、Hirosawa Tetsu、Kikuchi Mitsuru、Ito Shigeru、Minabe Yoshio、Ouchi Yasuomi
    • Journal Title

      Translational Psychiatry

      Volume: 9 Issue: 1 Pages: 1-10

    • DOI

      10.1038/s41398-019-0443-4

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Serotonergic Input to Orexin Neurons Plays a Role in Maintaining Wakefulness and REM Sleep Architecture2018

    • Author(s)
      Saito Yuki C.、Tsujino Natsuko、Abe Manabu、Yamazaki Maya、Sakimura Kenji、Sakurai Takeshi
    • Journal Title

      Frontiers in Neuroscience

      Volume: 12 Pages: 892-892

    • DOI

      10.3389/fnins.2018.00892

    • NAID

      120007133662

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Monoamines Inhibit GABAergic Neurons in Ventrolateral Preoptic Area That Make Direct Synaptic Connections to Hypothalamic Arousal Neurons2018

    • Author(s)
      Saito Yuki C.、Maejima Takashi、Nishitani Mitsuhiro、Hasegawa Emi、Yanagawa Yuchio、Mieda Michihiro、Sakurai Takeshi
    • Journal Title

      The Journal of Neuroscience

      Volume: 38 Issue: 28 Pages: 6366-6378

    • DOI

      10.1523/jneurosci.2835-17.2018

    • NAID

      120007133906

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Hypocretin/orexin deficiency decreases cocaine abuse liability2018

    • Author(s)
      Steiner Nadia、Rossetti Clara、Sakurai Takeshi、Yanagisawa Masashi、de Lecea Luis、Magistretti Pierre J.、Halfon Olivier、Boutrel Benjamin
    • Journal Title

      Neuropharmacology

      Volume: 133 Pages: 395-403

    • DOI

      10.1016/j.neuropharm.2018.02.010

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Similar Neural Correlates of Planning and Execution to Inhibit Continuing Actions2018

    • Author(s)
      Omata Kei、Ito Shigeru、Takata Youhei、Ouchi Yasuomi
    • Journal Title

      Frontiers in Neuroscience

      Volume: 12 Pages: 1-11

    • DOI

      10.3389/fnins.2018.00951

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Tryptophan-kynurenine and lipid related metabolites as blood biomarkers for first-episode drug-naive patients with major depressive disorder: an exploratory pilot case-control study.2018

    • Author(s)
      Kuwano N, Kato TA, Setoyama D, Sato-Kasai M, Shimokawa N, Hayakawa K, Ohgidani M, Sagata N, Kubo H, Kishimoto J, Kang D, Kanba S
    • Journal Title

      Journal of Affective Disorders

      Volume: 231 Pages: 74-82

    • DOI

      10.1016/j.jad.2018.01.014

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Is a Socio-Cultural Analysis of Depressive Disorders a Matter of Concern? Response to Kaiya2018

    • Author(s)
      Kato Takahiro A.、Kanba Shigenobu
    • Journal Title

      American Journal of Psychiatry

      Volume: 175 Issue: 5 Pages: 483-484

    • DOI

      10.1176/appi.ajp.2018.17121404r

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Does LINE addiction exist? Potential concerns about Japan's most popular form of social media on smartphones2018

    • Author(s)
      Tateno Masaru、Teo Alan R.、Kato Takahiro A.
    • Journal Title

      Psychiatry and Clinical Neurosciences

      Volume: 72 Issue: 7 Pages: 540-541

    • DOI

      10.1111/pcn.12672

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Harnessing Social Media to Explore Youth Social Withdrawal in Three Major Cities in China: Cross-Sectional Web Survey2018

    • Author(s)
      Liu Lucia Lin、Li Tim MH、Teo Alan R、Kato Takahiro A、Wong Paul WC
    • Journal Title

      JMIR Mental Health

      Volume: 5 Issue: 2 Pages: e34-e34

    • DOI

      10.2196/mental.8509

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Blood biomarkers of Hikikomori, a severe social withdrawal syndrome.2018

    • Author(s)
      Hayakawa K, Kato TA*, Watabe M, Teo AR, Horikawa H, Shimokawa N, Sato-Kasai M, Kubo H, Ohgidani M, Sagata N, Toda H, Tateno M, Shinfuku N, Kishimoto J, Kanba S
    • Journal Title

      Scientific Reports

      Volume: 8 Issue: 1 Pages: 2884-2884

    • DOI

      10.1038/s41598-018-21260-w

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Orexin modulates behavioral fear expression through the locus coeruleus2017

    • Author(s)
      Soya Shingo、Takahashi Tohru M.、McHugh Thomas J.、Maejima Takashi、Herlitze Stefan、Abe Manabu、Sakimura Kenji、Sakurai Takeshi
    • Journal Title

      Nature Communications

      Volume: 8 Issue: 1 Pages: 1606-1606

    • DOI

      10.1038/s41467-017-01782-z

    • NAID

      120007128779

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Orexin Receptor Multimerization versus Functional Interactions: Neuropharmacological Implications for Opioid and Cannabinoid Signalling and Pharmacogenetics2017

    • Author(s)
      Thompson Miles、Sakurai Takeshi、Rainero Innocenzo、Maj Mary、Kukkonen Jyrki
    • Journal Title

      Pharmaceuticals

      Volume: 10 Issue: 4 Pages: 79-79

    • DOI

      10.3390/ph10040079

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] xcitation of GABAergic neurons in the bed nucleus of the stria terminalis triggers immediate transition from non-rapid eye movement sleep to wakefulness in mice.2017

    • Author(s)
      Shota Kodani, Shingo Soya and Takeshi Sakurai
    • Journal Title

      Journal of Neuroscience

      Volume: 37 Issue: 30 Pages: 7164-7176

    • DOI

      10.1523/jneurosci.0245-17.2017

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Nonpeptide orexin type-2 receptor agonist ameliorates narcolepsy-cataplexy symptoms in mouse models2017

    • Author(s)
      Irukayama-Tomobe Y, Ogawa Y, Tominaga H, Ishikawa Y, Hosokawa N, Ambai S, Kawabe Y, Uchida S, Nakajima R, Saitoh T, Kanda T, Vogt K, Sakurai T, Nagase H, Yanagisawa M.
    • Journal Title

      Proc Natl Acad Sci U S A.

      Volume: 114 Issue: 22 Pages: 5731-5736

    • DOI

      10.1073/pnas.1700499114

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Fine-Tuning Circadian Rhythms: The Importance of Bmal1 Expression in the Ventral Forebrain.2017

    • Author(s)
      Mieda M, Hasegawa E, Kessaris N, Sakurai T
    • Journal Title

      Front Neurosci.

      Volume: 11 Pages: 55-55

    • DOI

      10.3389/fnins.2017.00055

    • NAID

      120006027787

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Serotonin neurons of the dorsal raphe mediate the anti-cataplectic action of orexin neurons by reducing the amygdala activity2017

    • Author(s)
      Hasegawa, E., Maejima, T., Yoshida, T., Masseck O.A., Herlitze, S., Yoshioka, M., Sakurai, T., Mieda, M.
    • Journal Title

      Proc Natl Acad Sci U S A.

      Volume: 114 Issue: 17

    • DOI

      10.1073/pnas.1614552114

    • Related Report
      2017 Annual Research Report 2016 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] The Lateral Occipito-temporal Cortex Is Involved in the Mental Manipulation of Body Part Imagery2017

    • Author(s)
      Kikuchi Mitsuru、Takahashi Tetsuya、Hirosawa Tetsu、Oboshi Yumi、Yoshikawa Etsuji、Minabe Yoshio、Ouchi Yasuomi
    • Journal Title

      Front Hum Neurosci.

      Volume: 11 Pages: 1-11

    • DOI

      10.3389/fnhum.2017.00181

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] pilot study of serotonergic modulation after long-term administration of oxytocin in autism spectrum disorder.2017

    • Author(s)
      Hirosawa T, Kikuchi M, Ouchi Y, Takahashi T, Yoshimura Y, Kosaka H, Furutani N, Hiraishi H, Fukai M, Yokokura M, Yoshikawa E, Bunai T, Minabe Y.
    • Journal Title

      Autism Res.

      Volume: - Issue: 5 Pages: 113-117

    • DOI

      10.1002/aur.1761

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Oxytocin effects on emotional response to others’ faces via serotonin system in autism: A pilot study2017

    • Author(s)
      Fukai Mina、Hirosawa Tetsu、Kikuchi Mitsuru、Ouchi Yasuomi、Takahashi Tetsuya、Yoshimura Yuko、Miyagishi Yoshiaki、Kosaka Hirotaka、Yokokura Masamichi、Yoshikawa Etsuji、Bunai Tomoyasu、Minabe Yoshio
    • Journal Title

      Psychiatry Res.

      Volume: 267 Pages: 45-50

    • DOI

      10.1016/j.pscychresns.2017.06.015

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Reversible amygdala enlargement: a longitudinal observation of a patient with elderly onset temporal lobe epilepsy2017

    • Author(s)
      Matsudaira Takashi、Omote Yoshio、Terada Tatsuhiro、Kondo Akihiko、Obi Tomokazu、Ouchi Yasuomi、Inoue Yushi
    • Journal Title

      J Neurol

      Volume: 264 Issue: 12 Pages: 2487-2490

    • DOI

      10.1007/s00415-017-8649-y

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Imaging neuroinflammation to monitor α-synucleinopathy.2017

    • Author(s)
      Ouchi Y
    • Journal Title

      Lancet Neurol.

      Volume: 16 Issue: 10 Pages: 763-764

    • DOI

      10.1016/s1474-4422(17)30244-2

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Shoplifting and eating disorders: an anonymous self-administered survey2017

    • Author(s)
      Yanase Maya、Sugihara Genichi、Murai Toshiya、Noma Shun’ichi
    • Journal Title

      Eat Weight Disord.

      Volume: 1 Issue: 6 Pages: 1-7

    • DOI

      10.1007/s40519-017-0394-9

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Collaborative roles of Temporoparietal Junction and Dorsolateral Prefrontal Cortex in Different Types of Behavioural Flexibility.2017

    • Author(s)
      Tei S, Fujino J, Kawada R, Jankowski KF, Kauppi JP, van den Bos W, Abe N, Sugihara G, Miyata J, Murai T, Takahashi H.
    • Journal Title

      Sci Rep.

      Volume: 7 Pages: 6415-6415

    • NAID

      120006368171

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Neural basis of altered earlier attention and higher order biological motion processing in schizophrenia.2017

    • Author(s)
      Matsumoto Y, Takahashi H, Miyata J, Sugihara G, Murai T, Takahashi H.
    • Journal Title

      Social Neuroscience

      Volume: Aug 25 Issue: 5 Pages: 1-8

    • DOI

      10.1080/17470919.2017.1366363

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Self-efficacy modulates the neural correlates of craving in male smokers and ex-smokers: an fMRI study2017

    • Author(s)
      Ono Miki、Kochiyama Takanori、Fujino Junya、Sozu Takashi、Kawada Ryosaku、Yokoyama Naoto、Sugihara Genichi、Murai Toshiya、Takahashi Hidehiko
    • Journal Title

      Addict Biol.

      Volume: 1 Issue: 5 Pages: 1-10

    • DOI

      10.1111/adb.12555

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Additive Effect of Cigarette Smoking on Gray Matter Abnormalities in Schizophrenia2017

    • Author(s)
      Yokoyama Naoto、Sasaki Hitoshi、Mori Yasuo、Ono Miki、Tsurumi Kousuke、Kawada Ryosaku、Matsumoto Yukiko、Yoshihara Yujiro、Sugihara Genichi、Miyata Jun、Murai Toshiya、Takahashi Hidehiko
    • Journal Title

      Schizophr Bull.

      Volume: 1 Pages: 1-10

    • DOI

      10.1093/schbul/sbx092

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Brain atrophy in the visual cortex and thalamus induced by severe stress in animal model2017

    • Author(s)
      Yoshii Takanobu、Oishi Naoya、Ikoma Kazuya、Nishimura Isao、Sakai Yuki、Matsuda Kenichi、Yamada Shunji、Tanaka Masaki、Kawata Mitsuhiro、Narumoto Jin、Fukui Kenji
    • Journal Title

      Scientific Reports

      Volume: 7 Issue: 1 Pages: 12731-12731

    • DOI

      10.1038/s41598-017-12917-z

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Modern-Type Depression as an "Adjustment" Disorder in Japan: The Intersection of Collectivistic Society Encountering an Individualistic Performance-Based System.2017

    • Author(s)
      Kato TA, Kanba S
    • Journal Title

      American Journal of Psychiatry

      Volume: 174(11) Issue: 11 Pages: 1051-1053

    • DOI

      10.1176/appi.ajp.2017.17010059

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed
  • [Journal Article] In vivo TSPO and cannabinoid receptor type 2 availability early in poststroke neuroinflammation in rats: a positron emission tomography study study.2017

    • Author(s)
      Hosoya T, Fukumoto D, Kakiuchi T, Nishiyama S, Yamamoto S, Ohba H, Tsukada H, Ueki T, Sato K, Ouchi Y.
    • Journal Title

      J Neuroinflammation.

      Volume: 29 Issue: 1 Pages: 69-78

    • DOI

      10.1186/s12974-017-0851-4

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Social Isolation During the Critical Period Reduces Synaptic and Intrinsic Excitability of a Subtype of Pyramidal Cell in Mouse Prefrontal Cortex.2017

    • Author(s)
      Yamamuro K, Yoshino H, Ogawa Y, Makinodan M, Toritsuka M, Yamashita M, Corfas G, Kishimoto T.
    • Journal Title

      Cereb Cortex.

      Volume: 1-13 Issue: 3 Pages: 998-1010

    • DOI

      10.1093/cercor/bhx010

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Microglia-derived neuregulin expression in psychiatric disorders.2017

    • Author(s)
      Ikawa D, Makinodan M, Iwata K, Ohgidani M, Kato TA, Yamashita Y, Yamamuro K, Kimoto S, Toritsuka M, Yamauchi T, Fukami SI, Yoshino H, Okumura K, Tanaka T, Wanaka A, Owada Y, Tsujii M, Sugiyama T, Tsuchiya K, Mori N, Hashimoto R, Matsuzaki H, Kanba S, Kishimoto T.
    • Journal Title

      Brain Behav Immun.

      Volume: 61 Pages: 375-385

    • DOI

      10.1016/j.bbi.2017.01.003

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Tumor necrosis factor-alpha expression in peripheral blood mononuclear cells correlates with early childhood social interaction in autism spectrum disorder.2017

    • Author(s)
      Makinodan M, Iwata K, Ikawa D, Yamashita Y, Yamamuro K, Toritsuka M, Kimoto S, Okumura K, Yamauchi T, Yoshino H, Tsujii M, Sugiyama T, Tsuchiya K, Mori N, Matsuzaki H, Kishimoto T.
    • Journal Title

      Neurochem Int.

      Volume: 104 Pages: 1-5

    • DOI

      10.1016/j.neuint.2016.12.005

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Acute Moderate Exercise Improves Mnemonic Discrimination in Young Adults.2017

    • Author(s)
      Suwabe K, Hyodo K, Byun K, Ochi G, Yassa MA, Soya H
    • Journal Title

      Hippocampus.

      Volume: 27 Issue: 3 Pages: 229-234

    • DOI

      10.1002/hipo.22695

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Moderate exercise ameliorates dysregulated hippocampal glycometabolism and memory function in a rat model of type 2 diabetes.2017

    • Author(s)
      Shima T, Matsui T, Jesmin S, Okamoto M, Soya M, Inoue K, Liu YF, Torres-Aleman I, McEwen BS and Soya H
    • Journal Title

      Diabetologia

      Volume: 60 Issue: 3 Pages: 597-606

    • DOI

      10.1007/s00125-016-4164-4

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Odour-induced analgesia mediated by hypothalamic orexin neurons in mice.2016

    • Author(s)
      Tashiro S, Yamaguchi R, Ishikawa S, Sakurai T, Kajiya K, Kanmura Y, Kuwaki T, Kashiwadani H.
    • Journal Title

      Sci Rep.

      Volume: 6 Issue: 1 Pages: 37129-37129

    • DOI

      10.1038/srep37129

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] QRFP-deficient mice are hypophagic, lean, hypoactive and exhibit increased anxiety-like behavior2016

    • Author(s)
      Okamoto K, Yamasaki M, Takao K, Soya S, Iwasaki M, Sasaki K, Magoori K, Sakakibara I, Miyakawa T, Mieda M, Watanabe M, Sakai J, Yanagisawa M, Sakurai T
    • Journal Title

      PLoS ONE

      Volume: 11 Issue: 11 Pages: e0164716-e0164716

    • DOI

      10.1371/journal.pone.0164716

    • NAID

      120007129233

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Manipulating the Cellular Circadian Period of Arginine Vasopressin Neurons Alters the Behavioral Circadian Period.2016

    • Author(s)
      Mieda M, Okamoto H, Sakurai T.
    • Journal Title

      Curr Biol.

      Volume: S0960-9822(16) Issue: 18 Pages: 30773-4

    • DOI

      10.1016/j.cub.2016.07.022

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Sleep Control, GPCRs, and Glucose Metabolism.2016

    • Author(s)
      Tsuneki H, Sasaoka T, Sakurai T.
    • Journal Title

      Trends Endocrinol Metab.

      Volume: 27(9) Issue: 9 Pages: 633-42

    • DOI

      10.1016/j.tem.2016.06.011

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Age-related gender-specific changes in the brain metabolism and morphology.2016

    • Author(s)
      Kakimoto A, Ito S, Okada H, Nishizawa S, Minoshima S, Ouchi Y.
    • Journal Title

      J Nucl Med.

      Volume: 57 Issue: 2 Pages: 221-5

    • DOI

      10.2967/jnumed.115.166439

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Depiction of microglial activation in aging and dementia: Positron emission tomography with [11C]DPA713 versus [11C](R)PK11195.2016

    • Author(s)
      Yokokura M, Terada T, Bunai T, Nakaizumi K, Takebayashi K, Iwata Y, Yoshikawa E, Futatsubashi M, Suzuki K, Mori N, Ouchi Y.
    • Journal Title

      J Cereb Blood Flow Metab.

      Volume: 37 Issue: 3 Pages: 877-889

    • DOI

      10.1177/0271678x16646788

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Social isolation impairs remyelination in mice through modulation of IL-6.2016

    • Author(s)
      Makinodan M, Ikawa D, Miyamoto Y, Yamauchi J, Yamamuro K, Yamashita Y, Toritsuka M, Kimoto S, Okumura K, Yamauchi T, Fukami SI, Yoshino H, Wanaka A, Kishimoto T.
    • Journal Title

      FASEB J.

      Volume: 30 Issue: 12 Pages: 4267-4274

    • DOI

      10.1096/fj.201600537r

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] People’s naivete about how extrinsic rewards influence intrinsic motivation.2016

    • Author(s)
      Murayama, Kou; Kitagami, Shinji; Tanaka, Ayumi; Raw, Jasmine A. L.
    • Journal Title

      Motivation Science

      Volume: 2 Issue: 3 Pages: 138-142

    • DOI

      10.1037/mot0000040

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Presentation] A novel neuronal circuit that induces hibernation-like state in rodents.2021

    • Author(s)
      Takeshi Sakurai
    • Organizer
      The 7th Neuroscience Network, Diversity of Brain Science
    • Related Report
      2020 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] A neuronal circuit that induces regulated hypometabolism in mice2020

    • Author(s)
      Takeshi Sakurai
    • Organizer
      Symposium 29: Role of preoptic neurons in thermoregulation, torpor, and fever virtual 8th International Conference on the Physiology and Pharmacology of Temperature Regulation
    • Related Report
      2020 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] ヒト血液を用いた精神疾患ミクログリア仮説解明のための橋渡し研究2020

    • Author(s)
      加藤隆弘
    • Organizer
      第50回日本神経精神薬理学会年会・第42回日本生物学的精神医学会年会・第4回日本精神薬学会総会
    • Related Report
      2020 Annual Research Report
    • Invited
  • [Presentation] ミクログリアの精神病理を探るためのヒト血液を用いた橋渡し研究2020

    • Author(s)
      加藤隆弘
    • Organizer
      第63回日本神経化学会大会
    • Related Report
      2020 Annual Research Report
    • Invited
  • [Presentation] フロイトの人間観:晩年の「死の欲動」の創出とその源泉にみる精神分析の目指すもの2020

    • Author(s)
      加藤隆弘
    • Organizer
      第116回日本精神神経学会学術総会
    • Related Report
      2020 Annual Research Report
    • Invited
  • [Presentation] Orexin Neurons at the Interface of Systems that Regulate Emotion and Arousal/Vigilance2018

    • Author(s)
      Takeshi Sakurai
    • Organizer
      10th International Peptide Symposium
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Role of orexin as a link between the limbic system and arousal2018

    • Author(s)
      Takeshi Sakurai
    • Organizer
      第 95 回日本生理学会大会
    • Related Report
      2018 Annual Research Report
    • Invited
  • [Presentation] Neuroinflammation and receptor availability that can be and should be depicted by PET2018

    • Author(s)
      Yasuomi Ouchi
    • Organizer
      第59回日本神経学会
    • Related Report
      2018 Annual Research Report
    • Invited
  • [Presentation] Dopaminergic activity-dependent astrocytic glycogenolysis producing lactate in the exercising hippocampus.2018

    • Author(s)
      Takashi Matsui, Ignacio Torres-Aleman, Hideaki Soya
    • Organizer
      第7回IIISシンポジウム
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Assessing the activating effect of stimulating agents with electrophysiological and behavioral measurements in rats.2018

    • Author(s)
      Francois Grenier, Yu-Fan Liu, Mariko Soya, Xin Lei, Hideaki Soya.
    • Organizer
      第2回NIPS-ARIHHP共同ワークショップ ヒューマン・ハイ・パフォーマンスの実現を目指した次世代健康スポーツ科学と神経科学の融合・統合
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research
  • [Presentation] In vivo depiction of neuroinflammation on the cholinergic system and cognition in humans.2018

    • Author(s)
      Yasuomi Ouchi
    • Organizer
      第13回 Internatioinal symposium of geriatirics and gerontology.
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Roles of Orexin Neurons at the Interface of Systems that regulate Emotion and Arousal/Vigilance2018

    • Author(s)
      Takeshi Sakurai
    • Organizer
      The 8th International Society of Radiation Neurobiology Conference ISRN-2018
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] 大脳辺縁系と覚醒系を結ぶオレキシンの役割2018

    • Author(s)
      櫻井 武
    • Organizer
      第 95 回日本生理学会大会
    • Related Report
      2017 Annual Research Report
    • Invited
  • [Presentation] Differences in TSPO and cannabinoid receptor CB2 binding at an early stage in poststroke neuroinflammation in living rats.2017

    • Author(s)
      Ouchi Y, Fukumoto D, Kakiuchi T, Nishiyama S, Yamamoto S, Ohba H, Hosoya T, Tsukada H.
    • Organizer
      第18回Brain/BrianPET
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] In vivo imaging of mitochondrial complex CM-1 in the human brain.2017

    • Author(s)
      Yasuomi Ouchi, Tatsuhiro Terada, Masami Futatsubashi, Bunai Tomoyasu, Masamichi Yokokura, Etsuji Yoshikawa, Hideo Tsukada.
    • Organizer
      第23回Annual Meeting of the Organization for Human Brain Mapping
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] モチベーションの脳機能イメージング2017

    • Author(s)
      大石直也
    • Organizer
      日本社会心理学会第58回大会(広島)
    • Related Report
      2017 Annual Research Report
    • Invited
  • [Presentation] 覚醒と行動の神経科学2017

    • Author(s)
      櫻井 武
    • Organizer
      日本社会心理学会第58回大会(広島)
    • Related Report
      2017 Annual Research Report
    • Invited
  • [Presentation] セロトニンによるオレキシンニューロンの制御が睡眠・覚醒状態に与える影響2017

    • Author(s)
      齊藤夕貴、前島隆司、辻野なつ子、阿部学、崎村建司、櫻井 武
    • Organizer
      日本睡眠学会第41回定期学術集会
    • Related Report
      2017 Annual Research Report
  • [Presentation] Neural circuits of orexin neurons:interface of systems of emotion and arousal/vigilance.2017

    • Author(s)
      Takeshi Sakurai
    • Organizer
      The 6th Annual IIIS Symposium
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] The Mechanism of Narcolepsy: what it tells on clinical perspective2017

    • Author(s)
      Takeshi Sakurai
    • Organizer
      2nd International Taiwanese Congress of Neurology
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] 情動と覚醒系の相互作用におけるオレキシンの役割2017

    • Author(s)
      櫻井 武
    • Organizer
      平成29年度生理学研究所研究会
    • Related Report
      2017 Annual Research Report
    • Invited
  • [Presentation] 覚醒と行動の制御におけるオレキシン系の生理機能2017

    • Author(s)
      櫻井 武
    • Organizer
      第30回口腔・咽頭学会総会ならびに学術講演会
    • Related Report
      2017 Annual Research Report
    • Invited
  • [Presentation] 睡眠・覚醒および行動の制御におけるオレキシンの役割2017

    • Author(s)
      櫻井 武
    • Organizer
      新学術領域研究「グリアアセンブリによる脳機能発現の制御と病態」第4回夏のワークショップ
    • Related Report
      2017 Annual Research Report
    • Invited
  • [Book] 「こころ」はいかにして生まれるのか 最新脳科学で解き明かす「情動」2018

    • Author(s)
      櫻井 武
    • Total Pages
      240
    • Publisher
      講談社
    • ISBN
      9784065135228
    • Related Report
      2018 Annual Research Report
  • [Book] 1日10分! 脳フィットネスを高める スローエアロビック―DVD付き2018

    • Author(s)
      征矢 英昭
    • Total Pages
      80
    • Publisher
      NHK出版
    • ISBN
      9784141992646
    • Related Report
      2018 Annual Research Report
  • [Book] 睡眠の科学・改訂新版 なぜ眠るのか なぜ目覚めるのか2017

    • Author(s)
      櫻井 武
    • Total Pages
      264
    • Publisher
      講談社
    • ISBN
      4065020263
    • Related Report
      2017 Annual Research Report
  • [Remarks]

    • URL

      http://willdynamics.com/

    • Related Report
      2018 Annual Research Report

URL: 

Published: 2016-07-04   Modified: 2022-01-27  

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