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Integrated analysis and regulation of cellular diversity

Administrative Group

Project AreaIntegrated analysis and regulation of cellular diversity
Project/Area Number 17H06324
Research Category

Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)

Allocation TypeSingle-year Grants
Review Section Complex systems
Research InstitutionJapanese Foundation for Cancer Research

Principal Investigator

FUJITA Naoya  公益財団法人がん研究会, がん化学療法センター, 所長 (20280951)

Co-Investigator(Kenkyū-buntansha) 宮園 浩平  東京大学, 大学院医学系研究科(医学部), 卓越教授 (90209908)
秋山 徹  東京大学, 定量生命科学研究所, 特任教授 (70150745)
越川 直彦  東京工業大学, 生命理工学院, 教授 (70334282)
Project Period (FY) 2017-06-30 – 2022-03-31
Project Status Completed (Fiscal Year 2022)
Budget Amount *help
¥49,140,000 (Direct Cost: ¥37,800,000、Indirect Cost: ¥11,340,000)
Fiscal Year 2021: ¥9,620,000 (Direct Cost: ¥7,400,000、Indirect Cost: ¥2,220,000)
Fiscal Year 2020: ¥9,620,000 (Direct Cost: ¥7,400,000、Indirect Cost: ¥2,220,000)
Fiscal Year 2019: ¥9,620,000 (Direct Cost: ¥7,400,000、Indirect Cost: ¥2,220,000)
Fiscal Year 2018: ¥9,620,000 (Direct Cost: ¥7,400,000、Indirect Cost: ¥2,220,000)
Fiscal Year 2017: ¥10,660,000 (Direct Cost: ¥8,200,000、Indirect Cost: ¥2,460,000)
Keywords癌 / 細胞・組織 / 遺伝子 / 臨床 / 数理科学 / 再生医療 / 分子標的治療 / 病理学
Outline of Final Research Achievements

In this Grant-in-Aid for Scientific Research on Innovative Area, we promoted interdisciplinary research by life science researchers and mathematics and bioinformatics researchers. We tried to integrate biological and mathematical research areas to elucidate the diversity of microenvironments, the cell-cell interactions among heterogenous cells, and the hierarchical formation originated from stem cells within organs. Mutual understanding and joint research progressed more than our expectation. We achieved not only to establish mathematical models from the biological and molecular research results but also to discover novel signaling pathways and molecules by feeding back from the new findings obtained by the mathematical models.

Academic Significance and Societal Importance of the Research Achievements

臓器の透明化による病態時の各種細胞の空間的位置情報の可視化と数理モデル解析による評価手法の開発、生体組織破綻に関与する分子に関する多次元時系列のタンパク質定量と数理モデル化、シングルセル解析データの解析プラットフォームの作製など、数多くの技術開発が行われた。また、コンピュータシミュレーションによる薬剤抵抗性がん細胞に対する新たな克服薬の推定と実証、老化などの摂動に対する腸管や骨髄組織中の細胞の変動や分化を予測する数理モデルの確立と実証など、数理シミュレーションから再び生物学へとフィードバックすることで新たなシグナル経路や分子の発見が得られるなど、想定以上の成果が得られた。

Report

(6 results)
  • 2022 Final Research Report ( PDF )
  • 2021 Annual Research Report
  • 2020 Annual Research Report
  • 2019 Annual Research Report
  • 2018 Annual Research Report
  • 2017 Annual Research Report
  • Research Products

    (64 results)

All 2022 2021 2020 2019 2018 2017 Other

All Int'l Joint Research (2 results) Journal Article (24 results) (of which Int'l Joint Research: 7 results,  Peer Reviewed: 24 results,  Open Access: 22 results,  Acknowledgement Compliant: 2 results) Presentation (31 results) (of which Int'l Joint Research: 2 results,  Invited: 4 results) Book (1 results) Remarks (2 results) Funded Workshop (4 results)

  • [Int'l Joint Research] Massachusetts General Hospital(米国)

    • Related Report
      2019 Annual Research Report
  • [Int'l Joint Research] Universite´ Paris-Saclay(フランス)

    • Related Report
      2019 Annual Research Report
  • [Journal Article] GSK3 inhibition circumvents and overcomes acquired lorlatinib resistance in ALK-rearranged non-small-cell lung cancer2022

    • Author(s)
      Shimizu Yuki、Okada Koutaroh、Adachi Jun、Abe Yuichi、Narumi Ryohei、Uchibori Ken、Yanagitani Noriko、Koike Sumie、Takagi Satoshi、Nishio Makoto、Fujita Naoya、Katayama Ryohei
    • Journal Title

      npj Precision Oncology

      Volume: 6 Issue: 1 Pages: 16-16

    • DOI

      10.1038/s41698-022-00260-0

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Platelet-derived lysophosphatidic acid mediated LPAR1 activation as a therapeutic target for osteosarcoma metastasis2021

    • Author(s)
      Takagi Satoshi、Sasaki Yuki、Koike Sumie、Takemoto Ai、Seto Yosuke、Haraguchi Mizuki、Ukaji Takao、Kawaguchi Tokuichi、Sugawara Minoru、Saito Masanori、Funauchi Yuki、Ae Keisuke、Matsumoto Seiichi、Fujita Naoya、Katayama Ryohei
    • Journal Title

      Oncogene

      Volume: 40 Issue: 36 Pages: 5548-5558

    • DOI

      10.1038/s41388-021-01956-6

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Gilteritinib overcomes lorlatinib resistance in ALK-rearranged cancer2021

    • Author(s)
      Mizuta Hayato、Okada Koutaroh、Araki Mitsugu、Adachi Jun、Takemoto Ai、Kutkowska Justyna、Maruyama Kohei、Friboulet Luc、Katayama Kazuhiro、Ma Biao、Sasakura Yoko、Sagae Yukari、Kukimoto-Niino Mutsuko、Shirouzu Mikako、Takagi Satoshi、Simizu Siro、Nishio Makoto、Okuno Yasushi、Fujita Naoya、Katayama Ryohei, et al
    • Journal Title

      Nature Communications

      Volume: 12 Issue: 1 Pages: 1261-1261

    • DOI

      10.1038/s41467-021-21396-w

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Whole-organ analysis of TGF-β-mediated remodelling of the tumour microenvironment by tissue clearing.2021

    • Author(s)
      Kubota SI, Takahashi K, Mano T, Matsumoto K, Katsumata T, Shi S, Tainaka K, Ueda HR, Ehata S, Miyazono K.
    • Journal Title

      Commun. Biol.

      Volume: 4 Issue: 1 Pages: 294-294

    • DOI

      10.1038/s42003-021-01786-y

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Cryo-EM structures reveal distinct mechanisms of inhibition of the human multidrug transporter ABCB12020

    • Author(s)
      Nosol Kamil、Romane Ksenija、Irobalieva Rossitza N.、Alam Amer、Kowal Julia、Fujita Naoya、Locher Kaspar P.
    • Journal Title

      Proceedings of the National Academy of Sciences

      Volume: 117 Issue: 42 Pages: 26245-26253

    • DOI

      10.1073/pnas.2010264117

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] NH2‐terminal fragment of ZF21 protein suppresses tumor invasion via inhibiting the interaction of ZF21 with FAK2020

    • Author(s)
      Makoto Nagano, Daisuke Hoshino, Jiro Toshima, Motoharu Seiki, Naohiko Koshikawa
    • Journal Title

      Cancer Science

      Volume: 111 Issue: 12 Pages: 4393-4404

    • DOI

      10.1111/cas.14665

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Epigenetic remodelling shapes inflammatory renal cancer and neutrophil-dependent metastasis2020

    • Author(s)
      Nishida Jun、Momoi Yusaku、Miyakuni Kosuke、Tamura Yusuke、Takahashi Kei、Koinuma Daizo、Miyazono Kohei、Ehata Shogo
    • Journal Title

      Nature Cell Biology

      Volume: 110 Issue: 4 Pages: 2063-2074

    • DOI

      10.1038/s41556-020-0491-2

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed
  • [Journal Article] UHRF1-KAT7-mediated regulation of TUSC3 expression via histone methylation/acetylation is critical for the proliferation of colon cancer cells2019

    • Author(s)
      Taniue Kenzui、Hayashi Tomoatsu、Kamoshida Yuki、Kurimoto Akiko、Takeda Yasuko、Negishi Lumi、Iwasaki Kei、Kawamura Yoshifumi、Goshima Naoki、Akiyama Tetsu
    • Journal Title

      Oncogene

      Volume: 39 Issue: 5 Pages: 1018-1030

    • DOI

      10.1038/s41388-019-1032-y

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Secreted PD-L1 variants mediate resistance to PD-L1 blockade therapy in non-small cell lung cancer2019

    • Author(s)
      Gong Bo, Kiyotani Kazuma, Sakata Seiji, Nagano Seiji, Kumehara Shun, Baba Satoko, Besse Benjamin, Yanagitani Noriko, Friboulet Luc, Nishio Makoto, Takeuchi Kengo, Kawamoto Hiroshi, Fujita Naoya, Katayama Ryohei
    • Journal Title

      The Journal of Experimental Medicine

      Volume: 216 Issue: 4 Pages: 982-1000

    • DOI

      10.1084/jem.20180870

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] The new-generation selective ROS1/NTRK inhibitor DS-6051b overcomes crizotinib resistant ROS1-G2032R mutation in preclinical models2019

    • Author(s)
      Katayama R、Bo G、Togashi N、Miyamoto M、Kiga M、Iwasaki S、Kamai Y、Tominaga Y、Takeda Y、Kagoshima Y、Shimizu Y、Seto Y、Oh-hara T、Koike S、Nakao N、Hanzawa H、Watanabe K、Yoda S、Yanagitani N、Hata AN.、Shaw AT、Nishio M、Fujita N、Isoyama T.
    • Journal Title

      Nature Communications

      Volume: 10 Issue: 1 Pages: 3604-3604

    • DOI

      10.1038/s41467-019-11496-z

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Utility of a reverse phase protein array to evaluate multiple biomarkers in diffuse large B‐cell lymphoma2019

    • Author(s)
      Suzuki M、Muroi A、Nojima M、Numata A、Takasaki H、Sakai R、Yokose T、Miyagi Y、Koshikawa N.
    • Journal Title

      Proteomics Clinical Applications

      Volume: 14 Issue: 1 Pages: 1900091-1900091

    • DOI

      10.1002/prca.201900091

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] The novel lncRNA CALIC upregulates AXL to promote colon cancer metastasis2019

    • Author(s)
      Kawasaki Y、Miyamoto M、Oda T、Matsumura K、Negishi L、Nakato R、Suda S、Yokota N、Shirahige K、Akiyama T.
    • Journal Title

      EMBO reports

      Volume: 20 Issue: 8

    • DOI

      10.15252/embr.201847052

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Prediction of ALK mutations mediating ALK-TKIs resistance and drug re-purposing to overcome the resistance2019

    • Author(s)
      Okada Koutaroh、Araki Mitsugu、Sakashita Takuya、Ma Biao、Kanada Ryo、Yanagitani Noriko、Horiike Atsushi、Koike Sumie、Oh-hara Tomoko、Watanabe Kana、Tamai Keiichi、Maemondo Makoto、Nishio Makoto、Ishikawa Takeshi、Okuno Yasushi、Fujita Naoya、Katayama Ryohei
    • Journal Title

      EBioMedicine

      Volume: 41 Pages: 105-119

    • DOI

      10.1016/j.ebiom.2019.01.019

    • NAID

      120006892063

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] A safety study of newly generated anti-podoplanin-neutralizing antibody in cynomolgus monkey (Macaca fascicularis).2018

    • Author(s)
      Ukaji T, Takemoto A, Katayama R, Takeuchi K, Fujita N
    • Journal Title

      Oncotarget

      Volume: 9 Issue: 70 Pages: 33322-33336

    • DOI

      10.18632/oncotarget.26055

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Identification of mutation accumulation as resistance mechanism emerging in first-line osimertinib treatment.2018

    • Author(s)
      Ken Uchibori, Naohiko Inase, Makoto Nishio, Naoya Fujita, Ryohei Katayama
    • Journal Title

      J. Thorac. Oncol.

      Volume: 13 Issue: 7 Pages: 915-925

    • DOI

      10.1016/j.jtho.2018.04.005

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] SIRT2-mediated inactivation of p73 is required for glioblastoma tumorigenicity2018

    • Author(s)
      Funato K, Hayashi T, Echizen K, Negishi L, Shimizu N, Koyama-Nasu R, Nasu-Nishimura Y, Morishita Y, Tabar V, Todo T, Ino Y, Mukasa A, Saito N & Akiyama T.
    • Journal Title

      EMBO Reports

      Volume: 19 Issue: 11 Pages: 45587-45587

    • DOI

      10.15252/embr.201745587

    • URL

      https://pure.teikyo.jp/en/publications/1b7d4895-cd45-4c46-a9b4-0f69f05cff5e

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Intracellular and extracellular TGF-β signaling in cancer: some recent topics.2018

    • Author(s)
      Kohei Miyazono, Yoko Katsuno, Daizo Koinuma, Shogo Ehata, Masato Morikawa
    • Journal Title

      Frontiers of Medicine

      Volume: 12 Issue: 4 Pages: 387-411

    • DOI

      10.1007/s11684-018-0646-8

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Targeting the Golgi apparatus to overcome acquired resistance of non-small cell lung cancer cells to EGFR tyrosine kinase inhibitors2017

    • Author(s)
      Yoshimi Ohashi, Mutsumi Okamura, Ryohei Katayama, Siyang Fang, Saki Tsutsui, Akinobu Akatsuka, Mingde Shan, Hyeong-Wook Choi, Naoya Fujita, Kentaro Yoshimatsu, Isamu Shiina, Takao Yamori, and Shingo Dan
    • Journal Title

      Oncotarget

      Volume: 9 Issue: 2 Pages: 1641-1655

    • DOI

      10.18632/oncotarget.22895

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Platelet-activating factor podoplanin: from discovery to drug development.2017

    • Author(s)
      Ai Takemoto, Kenichi Miyata, Naoya Fujita
    • Journal Title

      Cancer Metastasis Rev.

      Volume: 36 Issue: 2 Pages: 225-234

    • DOI

      10.1007/s10555-017-9672-2

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] A critical role of platelet TGF-b release in podoplanin-mediated tumour invasion and metastasis2017

    • Author(s)
      Takemoto A, Okitaka M, Takagi S, Takami M, Sato S, Nishio M, Okumura S, Fujita N
    • Journal Title

      Scientific Reports

      Volume: 7 Issue: 1 Pages: 42186-42186

    • DOI

      10.1038/srep42186

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Brigatinib combined with anti-EGFR antibody overcomes osimertinib resistance in EGFR-mutated non-small-cell lung cancer.2017

    • Author(s)
      Ken Uchibori, Naohiko Inase, Mitsugu Araki, Mayumi Kamada, Shigeo Sato, Yasushi Okuno, Naoya Fujita, Ryohei Katayama
    • Journal Title

      Nature Commun.

      Volume: 8 Issue: 1 Pages: 14768-14768

    • DOI

      10.1038/ncomms14768

    • NAID

      120006027079

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Podoplanin enhances lung cancer cell growth in vivo by inducing platelet aggregation2017

    • Author(s)
      Kenichi Miyata, Ai Takemoto, Sakae Okumura, Makoto Nishio, Naoya Fujita
    • Journal Title

      Sci. Rep.

      Volume: 7 Issue: 1 Pages: 4059-4059

    • DOI

      10.1038/s41598-017-04324-1

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] TKI-addicted ROS1-rearranged cells are destined to survival or death by the intensity of ROS1 kinase activity2017

    • Author(s)
      Hayato Ogura, Yuka Nagatake-Kobayashi, Jun Adachi, Takeshi Tomonaga, Naoya Fujita, Ryohei Katayama
    • Journal Title

      Sci. Rep.

      Volume: 7 Issue: 1 Pages: 5519-5519

    • DOI

      10.1038/s41598-017-05736-9

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] 8. Mechanisms of resistance to NTRK inhibitors and therapeutic strategies in NTRK1-rearranged cancers.2017

    • Author(s)
      Miho Jane Fuse, Koutaroh Okada, Tomoko Oh-hara, Hayato Ogura, Naoya Fujita, Ryohei Katayama
    • Journal Title

      Mol Cancer Ther.

      Volume: 16 Issue: 10 Pages: 2130-2143

    • DOI

      10.1158/1535-7163.mct-16-0909

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access
  • [Presentation] 骨肉腫に有効な新規分子標的薬の探索とその作用機序の解析2022

    • Author(s)
      高木 聡、小池 清恵、竹本 愛、藤田 直也、片山 量平
    • Organizer
      第26回日本がん分子標的治療学会
    • Related Report
      2021 Annual Research Report
  • [Presentation] 腫瘍微小環境を反映した薬剤感受性のための3D共培養腫瘍モデル2022

    • Author(s)
      高橋祐生、北野史朗、片山量平、長山聡、藤田直也
    • Organizer
      第81回日本癌学会学術総会
    • Related Report
      2021 Annual Research Report
  • [Presentation] Platelet-derived lysophosphatidic acid mediated LPAR1 activation as a therapeutic target for osteosarcoma metastasis2021

    • Author(s)
      Satoshi Takagi, Yuki Sasaki, Sumie Koike, Ai Takemoto, Yosuke Seto, Mizuki Haraguchi, Takao Ukaji, Tokuichi Kawaguchi, Minoru Sugawara, Masanori Saito, Yuki Funauchi, Keisuke Ae, Seiichi Matsumoto, Naoya Fujita, Ryohei Katayama
    • Organizer
      The 25th JFCR-ISCC symposium
    • Related Report
      2021 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 骨肉腫は活性型血小板からのリゾホスファチジン酸分泌を介して肺 転移を亢進する2021

    • Author(s)
      高木 聡、小池 清恵、竹本 愛、菅原 稔、藤田 直也、片山 量平
    • Organizer
      第80回日本癌学会学術総会
    • Related Report
      2021 Annual Research Report
  • [Presentation] 血管構造を有する層状間質組織との3D共培養モデルの開発とそれを用いた薬剤感受性試験2021

    • Author(s)
      高橋祐生、清水裕貴、北野史朗、長山聡、片山量平、藤田直也
    • Organizer
      第80回日本癌学会学術総会
    • Related Report
      2021 Annual Research Report
  • [Presentation] Regulation of cellular diversity in tumor microenvironment by platelet activation-inducing molecule Podoplanin2020

    • Author(s)
      Satoshi Takagi, Ryohei Katayama, Ai Takemoto, Naoya Fujita
    • Organizer
      第43回日本分子生物学会年会
    • Related Report
      2020 Annual Research Report
  • [Presentation] がん臨床検体を用いた免疫チェックポイント阻害薬耐性機構の探索と分泌型PD-L1バリアント2020

    • Author(s)
      片山量平、藤田直也
    • Organizer
      第24回日本がん分子標的治療学会
    • Related Report
      2020 Annual Research Report
    • Invited
  • [Presentation] 薬剤耐性変異予測モデル構築に向けたALK-TKIの薬効評価2020

    • Author(s)
      水田隼斗、大原智子、小池清恵、岩見真吾、清水史郎、藤田直也、片山量平
    • Organizer
      第79回日本癌学会学術総会
    • Related Report
      2020 Annual Research Report
  • [Presentation] 腫瘍組織の多様性とがんの薬物療法抵抗性2019

    • Author(s)
      片山量平、キョウ博、瀬戸陽介、藤田直也
    • Organizer
      第92回日本生化学会大会
    • Related Report
      2019 Annual Research Report
    • Invited
  • [Presentation] 血小板活性化因子Podoplaninが作り出すがん免疫逃避環境の解析2019

    • Author(s)
      古賀美菜穂、小池清恵、藤田直也、竹本愛、片山量平、高木聡
    • Organizer
      第42回日本分子生物学会年会
    • Related Report
      2019 Annual Research Report
  • [Presentation] ポドプラニンを介した腫瘍免疫微小環境の制御2019

    • Author(s)
      高木聡、小池清恵、藤田直也、片山量平
    • Organizer
      第78回日本癌学会学術総会
    • Related Report
      2019 Annual Research Report
  • [Presentation] 血小板活性化因子PDPNを介した腫瘍免疫微小環境の制御2019

    • Author(s)
      高木聡、小池清恵、藤田直也、片山量平
    • Organizer
      第23回日本がん分子標的治療学会
    • Related Report
      2019 Annual Research Report
  • [Presentation] 初回治療オシメルチニブ後に予想される変異蓄積による獲得耐性機構2018

    • Author(s)
      内堀健、北園聡、柳谷典子、堀池篤、西尾誠人、稲瀬直彦、藤田直也、片山量平
    • Organizer
      肺癌学会
    • Related Report
      2018 Annual Research Report
  • [Presentation] KRAS変異大腸がんにおける分子プロファイリングに基づく新規併用治療法の探索2018

    • Author(s)
      キョウ博、清水裕貴、大原智子、長山聡、藤田直也、片山量平
    • Organizer
      第77回 日本癌学会学術総会
    • Related Report
      2018 Annual Research Report
  • [Presentation] BRAF V600E変異陽性大腸がんにおける新たなサブグループの発見2018

    • Author(s)
      清水裕貴、キョウ博、大原智子、長山聡、藤田直也、片山量平
    • Organizer
      第77回 日本癌学会学術総会
    • Related Report
      2018 Annual Research Report
  • [Presentation] がんと血小板の結合を標的とする化合物の探索と解析2018

    • Author(s)
      竹本愛、片山量平、藤田直也
    • Organizer
      第77回 日本癌学会学術総会
    • Related Report
      2018 Annual Research Report
  • [Presentation] Her2 活性化変異陽性肺がん細胞株の樹立とキナーゼ阻害薬の評価2018

    • Author(s)
      大原智子、藤田直也、片山量平
    • Organizer
      第77回 日本癌学会学術総会
    • Related Report
      2018 Annual Research Report
  • [Presentation] オシメルチニブ初回治療のシーケンスで予想される耐性機構としての多重変異について2018

    • Author(s)
      内堀健、西尾誠人、稲瀬直彦、藤田直也、片山量平
    • Organizer
      第16回 日本臨床腫瘍学会学術集会
    • Related Report
      2018 Annual Research Report
  • [Presentation] サルポドプラニンの血小板凝集誘導活性におけるPLAG4ドメインの役割2018

    • Author(s)
      宇梶太雄、竹本愛、藤田直也
    • Organizer
      第27回日本がん転移学会学術集会
    • Related Report
      2018 Annual Research Report
  • [Presentation] がん患者検体を用いた腫瘍組織の統合解析と新薬開発2018

    • Author(s)
      藤田直也
    • Organizer
      理研・生命医科学シンポジウム「新たな生命医科学の融合 ~ゲノム・免疫・疾患システムを究める~」
    • Related Report
      2017 Annual Research Report
    • Invited
  • [Presentation] 1st and 2nd generation ALK-TKI rescues the next-generation ALK-TKI resistance mediated by double mutations.2017

    • Author(s)
      Koutaroh Okada, Shigeo Sato, Naoya Fujita, Ryohei Katayama
    • Organizer
      The 22nd International Symposium on Cancer Chemotherapy
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] ブリガチニブと抗EGFR抗体の併用がC797S/T790M変異によるオシメルチニブ耐性を克服する2017

    • Author(s)
      内堀 健、藤田直也、片山量平
    • Organizer
      第76回日本癌学会学術総会
    • Related Report
      2017 Annual Research Report
  • [Presentation] Driver Oncogene陽性肺がんにおける獲得耐性の分子基盤と新たな治療戦略2017

    • Author(s)
      片山量平、藤田直也
    • Organizer
      第76回日本癌学会学術総会
    • Related Report
      2017 Annual Research Report
    • Invited
  • [Presentation] Resistance mechanisms to NTRK-TKIs in NTRK1 rearranged cancer2017

    • Author(s)
      大原智子、佐藤重夫、藤田直也、片山量平
    • Organizer
      第76回日本癌学会学術総会
    • Related Report
      2017 Annual Research Report
  • [Presentation] Re-sensitization to 1st and 2nd generation ALK-TKI by secondary acquired mutation mediated 3rd ALK-TKI resistance.2017

    • Author(s)
      岡田康太郎、藤田直也、片山量平
    • Organizer
      平成29年度新学術領域研究「学術研究支援基盤形成【先端モデル動物支援プラットフォーム】」若手支援技術講習会
    • Related Report
      2017 Annual Research Report
  • [Presentation] EGFR-C797S/T790M多剤耐性肺癌に対する新規療法2017

    • Author(s)
      内堀健、稲瀬直彦、荒木望嗣、鎌田真由美、佐藤重男、奥野恭史、藤田直也、片山量平
    • Organizer
      第15回日本臨床腫瘍学会学術集会
    • Related Report
      2017 Annual Research Report
  • [Presentation] ポドプラニンが誘導する血小板TGF- 放出による転移促進機構2017

    • Author(s)
      竹本愛、藤田直也
    • Organizer
      第26回日本がん転移学会学術集会
    • Related Report
      2017 Annual Research Report
  • [Presentation] ゲノムワイドなshRNAライブラリーを用いた新規転移抑制分子の同定2017

    • Author(s)
      宮田憲一、竹本愛、藤田直也
    • Organizer
      第26回日本がん転移学会学術集会
    • Related Report
      2017 Annual Research Report
  • [Presentation] G1202R変異型EML4-ALKの変異蓄積による次世代ALK阻害剤Lorlatinib耐性の獲得2017

    • Author(s)
      岡田康太郎、藤田直也、片山量平
    • Organizer
      第20回日本がん分子標的治療学会
    • Related Report
      2017 Annual Research Report
  • [Presentation] Driver oncogene陽性肺がんにおける多様な分子標的薬耐性とその克服法2017

    • Author(s)
      片山量平、藤田直也
    • Organizer
      第20回日本がん分子標的治療学会
    • Related Report
      2017 Annual Research Report
  • [Presentation] cMET増幅を介したALK阻害薬耐性とその克服法2017

    • Author(s)
      小池清恵、藤田直也、片山量平
    • Organizer
      第20回日本がん分子標的治療学会
    • Related Report
      2017 Annual Research Report
  • [Book] がん微小環境に1細胞レベルで挑む2021

    • Author(s)
      藤田 直也
    • Total Pages
      220
    • Publisher
      羊土社
    • ISBN
      9784758103961
    • Related Report
      2021 Annual Research Report
  • [Remarks] 新学術領域研究「細胞ダイバース」ホームページ

    • URL

      http://cdiversity.umin.jp/index.html

    • Related Report
      2021 Annual Research Report 2020 Annual Research Report
  • [Remarks] 新学術領域「細胞ダイバース」ホームページ

    • URL

      http://cdiversity.umin.jp/index.html

    • Related Report
      2019 Annual Research Report 2018 Annual Research Report 2017 Annual Research Report
  • [Funded Workshop] 第25回JFCR-ISCCシンポジウム2021

    • Related Report
      2021 Annual Research Report
  • [Funded Workshop] The 24th JFCR-ISCC Symposium2019

    • Related Report
      2019 Annual Research Report
  • [Funded Workshop] The 23rd International Symposium on Cancer Chemotherapy2018

    • Related Report
      2018 Annual Research Report
  • [Funded Workshop] The 22nd International Symposium on Cancer Chemotherapy.2017

    • Related Report
      2017 Annual Research Report

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Published: 2017-07-04   Modified: 2024-01-30  

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