Proteolysis in the Regulation of Biological Processes

• Project Area: Proteolysis in the Regulation of Biological Processes
• Project/Area Number: 18076008
• Research Category: Grant-in-Aid for Scientific Research on Priority Areas
• Allocation Type: Single-year Grants
• Review Section: Biological Sciences
• Research Institution: Tokyo Medical and Dental University
• Principal Investigator: MIZUSHIMA Noboru 東京医科歯科大学, 大学院・医歯学総合研究科, 教授 (10353434)
• Co-Investigator(Kenkyū-buntansha): SORIMACHI Hiroyuki 東京都医学研究機構, 東京都臨床医学総合研究所, 参事研究員 (10211327) ; IWAI Kazuhiro 大阪大学, 生命機能研究科, 教授 (60252459) ; SAKAI Yasuyoshi 京都大学, 農学研究科 (60202082) ; 杤尾 豪人 京都大学, 工学研究科, 准教授 (70336593) ; 千葉 智樹 筑波大学, 大学院・生命環境科学研究科, 教授 (00311423)
• Co-Investigator(Renkei-kenkyūsha): KOMINAMI Eiki 東京医科歯科大学 ; YOSHIDA Masasuke 東京医科歯科大学 ; NAGATA Kazuhiro 東京医科歯科大学 ; TANAKA Keiji 東京医科歯科大学 ; UCHIYAMA Yasuo 東京医科歯科大学 ; OHSUMI Yoshinori 東京医科歯科大学 ; SUZUKI Koichi 東京医科歯科大学
• Project Period (FY): 2006 – 2011
• Project Status: Completed (Fiscal Year 2011)
• Budget Amount: ¥45,000,000 (Direct Cost: ¥45,000,000); Fiscal Year 2011: ¥3,000,000 (Direct Cost: ¥3,000,000); Fiscal Year 2010: ¥7,600,000 (Direct Cost: ¥7,600,000); Fiscal Year 2009: ¥11,500,000 (Direct Cost: ¥11,500,000); Fiscal Year 2008: ¥7,600,000 (Direct Cost: ¥7,600,000); Fiscal Year 2007: ¥9,600,000 (Direct Cost: ¥9,600,000); Fiscal Year 2006: ¥5,700,000 (Direct Cost: ¥5,700,000)
• Keywords: タンパク質分解 / ユビキチン / オートファジー / カルパイン / プロテアーゼ / プロテオリシス / 細胞内情報伝達 / 細胞構造・機能 / 構造生物学

Research Abstract

本研究課題は平成18年度～22年度の科学研究費補助金・特定領域研究「タンパク質分解による細胞・個体機能の制御」の成果とりまとめを行うものである。本特定領域ではタンパク質分解系に視点をおき、その制御機構と役割について研究を行った。タンパク質分解の制御機構の研究では、各分解系の分解基質の同定、オートファゴソーム膜による特異的基質認識、オートファジー誘導、ユビキチンリガーゼの多様性・基質識別・活性制御、プロテアソームによるユビキチン鎖認識、カルパインの活性・基質特異性制御などについて成果が得られた。一方、タンパク質分解系の機能については、領域内共同研究などを推進することで、細胞内タンパク質・オルガネラ品質管理、抗原提示、筋分解の研究において、異なる分解系間の時空間的連携を明らかにした。計画班員・公募班員からこれらの成果とその後の進展に関する情報を再度収集し、それを最終報告書としてまとめた。最終報告書では、班員の個別報告に加えて、巻頭に研究成果の一覧表をテーマ別にわけて作成した。また、巻末には、キーワード毎の研究者(班員)索引を設け、領域終了後にも共同研究や相互連絡に活用できるよう工夫を施した。冊子体報告書の作製は平成24年1月に終了し、班員や関係各所に配布した。また、領域内の情報交換の場であるインターネットウェブを利用した「プロテオリシスフォーラム」は本年度も継続した。2009年4月からのカウントでは39500件を超えるアクセスがあり、スレッド数も計288件に達した。これは領域内のコミュニケーションだけではなく、タンパク質分解研究領域全体に大きく貢献した。

Research Products

• [Journal Article] Autophagy : renovation of cells and tissues (2011)
  • Author(s): Mizushima, N.
  • Journal Title: Cell Volume: 147 Issue: 4 Pages: 728-741
  • DOI: 10.1016/j.cell.2011.10.026
  • Peer Reviewed
• [Journal Article] A comprehensive glossary of autophagy-related molecules and processes (2^<nd> edition) (2011)
  • Author(s): Klionsky, D.J.
  • Journal Title: Autophagy Volume: 7 Issue: 11 Pages: 1273-1294
  • DOI: 10.4161/auto.7.11.17661
  • Peer Reviewed
• [Journal Article] The Role of Atg Proteins in Autophagosome Formation (2011)
  • Author(s): Mizushima, N.
  • Journal Title: Annu.Rev.Cell Dev.Biol. Volume: 27 Issue: 1 Pages: 107-132
  • DOI: 10.1146/annurev-cellbio-092910-154005
  • Peer Reviewed
• [Journal Article] 哺乳動物におけるオートファジーの生理的役割 (2011)
  • Author(s): 久万亜紀子
  • Journal Title: 実験医学増刊号 Volume: 29 Pages: 133-139
• [Journal Article] 原虫のオートファジー (2011)
  • Author(s): 北村圭
  • Journal Title: 炎症と免疫 Volume: 20 Pages: 170-176
• [Journal Article] オートファジーの制御シグナル (2011)
  • Author(s): 貝塚剛志
  • Journal Title: 内分泌・糖尿病・代謝内科 Volume: 33 Pages: 365-370
• [Journal Article] オートファジーを駆動するシグナリング (2011)
  • Author(s): 貝塚剛志
  • Journal Title: 実験医学 Volume: 29 Pages: 127-132
• [Journal Article] 飢餓におけるmTORの役割:オートファジー誘導とリソソーム生合成 (2011)
  • Author(s): 久万亜紀子
  • Journal Title: 実験医学 Volume: 29 Pages: 877-882
• [Journal Article] 飢餓における細胞応答:オートファジー (2011)
  • Author(s): 久万亜紀子
  • Journal Title: アディポサイエンス Volume: 7 Pages: 199-205
• [Journal Article] オートファジーの受精卵発生における役割 (2011)
  • Author(s): 塚本智史
  • Journal Title: Hormone Frontier in Gynecology Volume: 12 Pages: 53-58
• [Journal Article] オートファジーの分子機構と生理機能 (2011)
  • Author(s): 貝塚剛志
  • Journal Title: 血液内科 Volume: 62 Pages: 127-134
• [Journal Article] オートファジーと癌抑制 (2011)
  • Author(s): 西村多喜
  • Journal Title: 実験医学 Volume: 29 Pages: 236-241
• [Journal Article] Crohn disease : A current perspective on genetics, autophagy and immunity. (2011)
  • Author(s): Stappenbeck, T.S.
  • Journal Title: Autophagy Volume: 7 Pages: 1-20
  • Peer Reviewed
• [Journal Article] Autophagy in immunity and inflammation. (2011)
  • Author(s): Levine, B
  • Journal Title: Nature Volume: 469 Pages: 323-335
  • Peer Reviewed
• [Journal Article] Calpain chronicle-an enzyme family under multidisciplinary characterization. (2011)
  • Author(s): Sorimachi, H
  • Journal Title: Proc.Jpn.Acad.Ser.B Volume: 87(in press)
  • NAID: 130000903736
  • Peer Reviewed
• [Journal Article] Methods in mammalian autophagy research. (2010)
  • Author(s): Mizushima, N., Yoshimori, T., Levine, B.
  • Journal Title: Cell 140 Pages: 313-326
• [Journal Article] Noboru Mizushima : All about autophagy. Interview by Caitlin Sedwick. (2010)
  • Author(s): Mizushima, N.
  • Journal Title: J.Cell Biol. 190 Pages: 946-947
• [Journal Article] Autophagy in mammalian development and differentiation. (2010)
  • Author(s): Mizushima, N., Levine, B.
  • Journal Title: Nat.Cell Biol. 12 Pages: 823-830
• [Journal Article] Noboru Mizushima : All about autophagy. Interview by Caitlin Sedwick. (2010)
  • Author(s): Mizushima, N.
  • Journal Title: J.Cell Biol. Volume: 190 Pages: 946-947
  • Peer Reviewed
• [Journal Article] Autophagy in mammalian development and differentiation. (2010)
  • Author(s): Mizushima, N.
  • Journal Title: Nat.Cell Biol. Volume: 12 Pages: 823-830
  • Peer Reviewed
• [Journal Article] A comprehensive glossary of autophagy-related molecules and processes. (2010)
  • Author(s): Klionsky, D.J
  • Journal Title: Autophagy Volume: 6 Pages: 438-448
  • Peer Reviewed
• [Journal Article] Physiological role of autophagy as an intracellular recycling system : With an emphasis on nutrient metabolism. (2010)
  • Author(s): Kuma, A.
  • Journal Title: Semin.Cell Dev.Biol. Volume: 21 Pages: 683-690
  • Peer Reviewed
• [Journal Article] Autophagy (2010)
  • Author(s): Mizushima, N.
  • Journal Title: FEBS Lett. Volume: 584 Pages: 1279-1279
  • Peer Reviewed
• [Journal Article] Methods in mammalian autophagy research. (2010)
  • Author(s): Mizushima, N.
  • Journal Title: Cell Volume: 140 Pages: 313-326
  • Peer Reviewed
• [Journal Article] The role of the Atg1/ULK1 complex in autophagy regulation. (2010)
  • Author(s): Mizushima, N.
  • Journal Title: Curr Opin Cell Biol. Volume: 22 Pages: 132-139
  • Peer Reviewed
• [Journal Article] オートファジーの生理的役割 (2010)
  • Author(s): 水島昇
  • Journal Title: Medical Science Digest Volume: 36 Pages: 788-789
• [Journal Article] Expanding members and roles of the calpain superfamily and their genetically modified animals (2010)
  • Author(s): Sorimachi, H
  • Journal Title: Exp.Anim. Volume: 59 Pages: 549-566
  • NAID: 130000419250
  • Peer Reviewed
• [Journal Article] Une contribution a l'histoire de la decouverte des calpainopathies. (2010)
  • Author(s): Fardeau, M
  • Journal Title: Les Cahiers de Myologie Volume: 2 Pages: 5-10
• [Journal Article] Peroxisomes as dynamic organelles : autophagic degradation. (2010)
  • Author(s): Oku, M
  • Journal Title: FEBS Journal Volume: 277 Pages: 3289-3294
  • Peer Reviewed
• [Journal Article] Methods in mammalian autophagy research (2010)
  • Author(s): 水島昇
  • Journal Title: Cell 140 Pages: 313-326
  • Peer Reviewed
• [Journal Article] Methods for monitoring autophagy using GFP-LC3 transgenic mice. (2009)
  • Author(s): Mizushima N.
  • Journal Title: Methods Enzymol. 452 Pages: 13-23
• [Journal Article] Physiological functions of autophagy (2009)
  • Author(s): 水島昇
  • Journal Title: Curr Top Microbiol Immunol. 335 Pages: 71-84
  • Peer Reviewed
• [Journal Article] A receptor for eating mitochondria (2009)
  • Author(s): Ishihara, N.
  • Journal Title: Dev.Cell 17 Pages: 1-2
  • Peer Reviewed
• [Journal Article] オートファジー研究の多様化と現在求められていること (2009)
  • Author(s): 水島昇
  • Journal Title: 臨床検査 53 Pages: 1517-1518
• [Journal Article] オートファジーの分子機構 (2009)
  • Author(s): 岸千絵子
  • Journal Title: 臨床検査 53 Pages: 1519-1525
• [Journal Article] 栄養シグナルの感じ方・伝え方 基礎の基礎 (2009)
  • Author(s): 水島昇
  • Journal Title: 細胞工学 28 Pages: 754-759
• [Journal Article] Methods for monitoring autophagy using GFP-LC3 transgenic mice (2009)
  • Author(s): Mizushima N
  • Journal Title: Methods Enzymol 452 Pages: 13-23
• [Journal Article] Macroautophagy, endogenous MHC II loading and T cell selection : the benefits of breaking the rules (2009)
  • Author(s): Nedjic, J.
  • Journal Title: Curr Opin Immunol (In press)
  • Peer Reviewed
• [Journal Article] Atg14 and UVRAG : Mutually exclusive subunits of mammalian Beclin1-PI3K complexes (2009)
  • Author(s): Itakura, E
  • Journal Title: Autophagy 5(In press)
  • Peer Reviewed
• [Journal Article] When more is less : Excess and deficiency of autophagy coexist in skeletal muscle in Pompe disease. (2009)
  • Author(s): Raben, N
  • Journal Title: Autophagy 5 Pages: 111-113
  • Peer Reviewed
• [Journal Article] Role of ULK-FIP200 complex in mammalian autophagy : FIP200, a counterpart of yeast Atg17? (2009)
  • Author(s): Hara, T.
  • Journal Title: Autophagy 5 Pages: 85-87
  • Peer Reviewed
• [Journal Article] Methanol-inducible gene expression and heterologous protein production in the methylotrophic yeast Candida boidinii (2009)
  • Author(s): Ymrimoto, H
  • Journal Title: Biotechnology and Applied Biochemistry (In press)
  • Peer Reviewed
• [Journal Article] Autophagy fights disease through cellular self-digestion (2008)
  • Author(s): Mizushima, N., Levine, B., Cuervo, A.M., Klionsky, D.J.
  • Journal Title: Nature 451 Pages: 1069-1075
• [Journal Article] Guidelines for the use and interpretation of assays for monitoring autophagy in higher eukaryotes. (2008)
  • Author(s): Klionsky, D.J., et al.
  • Journal Title: Autophagy 4 Pages: 151-175
• [Journal Article] Autophagy fights disease through cellular self-digestion (2008)
  • Author(s): Mizushima, N., Levine, B., Cuervo, A.M., Klionsky, D.J
  • Journal Title: Nature 451 Pages: 1069-1075
• [Journal Article] The role of autophagy during the oocyte-to-embryo transition (2008)
  • Author(s): Tsukamoto, S.
  • Journal Title: Autophagy 4 Pages: 1076-1078
  • Peer Reviewed
• [Journal Article] 発生・分化とオートファジー (2008)
  • Author(s): 水島昇
  • Journal Title: 蛋白質核酸酵素 53 Pages: 2170-2174
• [Journal Article] オートファジーはマウス着床前胚の発生に必須である (2008)
  • Author(s): 塚本智史
  • Journal Title: 細胞工学 27 Pages: 1032-1033
• [Journal Article] オートファジーによる抗原提示 (2008)
  • Author(s): 高村聡人
  • Journal Title: 炎症と免疫 16 Pages: 399-403
• [Journal Article] 鉄代謝を制御するタンパク質分解システム (2008)
  • Author(s): 岩井一宏
  • Journal Title: 癌と化学療法 35 Pages: 16-20
• [Journal Article] ユビキチン (2008)
  • Author(s): 岩井一宏
  • Journal Title: 蛋白質核酸酵素 53 Pages: 1012-1012
• [Journal Article] ユビキチン修飾によるタンパク質機能制御機構の分子基盤 (2008)
  • Author(s): 岩井一宏
  • Journal Title: 実験医学 26 Pages: 2356-2361
• [Journal Article] Pexophagy in Pichia pastoris (2008)
  • Author(s): Oku, M
  • Journal Title: Methods Enzymol 451 Pages: 217-228
  • Peer Reviewed
• [Journal Article] Autophagy fights disease through cellular self-digestion. (2008)
  • Author(s): Mizushima, N.
  • Journal Title: Nature 451 Pages: 1069-1075
  • Peer Reviewed
• [Journal Article] Guidelines for the use and interpretation of assays for monitoring autophagy in higher eukaryotes. (2008)
  • Author(s): Klionsky, D. J. et. al.
  • Journal Title: Autophagy 4 Pages: 151-75
  • Peer Reviewed
• [Journal Article] オートファジー概論 (2008)
  • Author(s): 水島昇
  • Journal Title: 実験医学 26 Pages: 255-260
• [Journal Article] Autophagy : process and function (2007)
  • Author(s): Mizushima, N.
  • Journal Title: Genes Dev. 21 Pages: 2861-2873
• [Journal Article] How to interpret LC3 immunoblotting (2007)
  • Author(s): Mizushima, N., Yoshimori, T.
  • Journal Title: Autophagy 3 Pages: 542-545
• [Journal Article] Collaboration of proteolytic systems. (2007)
  • Author(s): Mizushima, N.
  • Journal Title: Autophagy 3 Pages: 179-180
• [Journal Article] Autophagy : process and function (2007)
  • Author(s): Mizushima, N
  • Journal Title: Genes Dev 21 Pages: 2861-2873
• [Journal Article] How to interpret LC3 immunoblotting (2007)
  • Author(s): Mizushima, N., Yoshimori, T
  • Journal Title: Autophagy 3 Pages: 542-545
• [Journal Article] Collaboration of proteolytic systems (2007)
  • Author(s): Mizushima, N
  • Journal Title: Autophagy 3 Pages: 179-180
• [Journal Article] rotein turnover via autophagy : Implications for metabolism (2007)
  • Author(s): izushima, N., Klionsky, D.J
  • Journal Title: Annu. Rev. Nutr 27 Pages: 19-39
• [Journal Article] Autophagy: process and function (2007)
  • Author(s): Mizushima, N.
  • Journal Title: Genes Dev 21 Pages: 2861-2873
  • Peer Reviewed
• [Journal Article] How to interpret LC3 immunoblotting: (2007)
  • Author(s): Mizushima, N.
  • Journal Title: Autophagy 3 Pages: 542-545
  • Peer Reviewed
• [Journal Article] Collaboration of proteolytic systems (2007)
  • Author(s): Mizushima, N.
  • Journal Title: Autophagy (印刷中)
• [Journal Article] Protein turnover via autophagy : Implications for metabolism. (2007)
  • Author(s): Mizushima, N. et al.
  • Journal Title: Annu. Rev. Nutr. 27 Pages: 19-39
• [Journal Article] The role of mammalian autophagy in protein metabolism (2007)
  • Author(s): Mizushima, N.
  • Journal Title: P. JPN Acad. B-Phys 82 Pages: 39-46
  • NAID: 130000093911
• [Journal Article] オートファジー (2006)
  • Author(s): 水島昇
  • Journal Title: 炎症と免疫 121 Pages: 569-571
• [Journal Article] オートファジーのモニター方法 : 現状と課題 (2006)
  • Author(s): 水島昇
  • Journal Title: 蛋白質核酸酵素 51 Pages: 1542-1548
• [Presentation] Physiological role of autophagy and its regulation mechanism (2012)
  • Author(s): Noboru Mizushima
  • Organizer: The 6th Global COE international symposium "Molecular control of bone remodeling"
  • Place of Presentation: Tokyo(招待講演)
  • Year and Date: 2012-01-24
• [Presentation] Autophagy regulation in cells and whole organisms (2012)
  • Author(s): Noboru Mizushima
  • Organizer: 2012 Senri Life Science International Symposium "Cutting-edge of Autophagy Study"
  • Place of Presentation: Osaka(招待講演)
  • Year and Date: 2012-01-20
• [Presentation] Autophagy in cells and whole organisms (2012)
  • Author(s): Noboru Mizushima
  • Organizer: Gordon Research Conference "Autophagy in stress, development and disease"
  • Place of Presentation: Ventura, CA, USA(招待講演)
• [Presentation] オートファジーの分子機構と生理機能 (2011)
  • Author(s): 水島昇
  • Organizer: 第40回日本免疫学会学術集会
  • Place of Presentation: 幕張(招待講演)
  • Year and Date: 2011-11-28
• [Presentation] オートファジーが支える哺乳類の個体発生 (2011)
  • Author(s): 水島昇
  • Organizer: 第1回都医学研シンポジウム
  • Place of Presentation: 東京(招待講演)
  • Year and Date: 2011-10-27
• [Presentation] Physiological roles of autophagy (2011)
  • Author(s): Noboru Mizushima
  • Organizer: The 16th Japan-Korea Symposium on Diabetes Mellitus
  • Place of Presentation: Urayasu(招待講演)
  • Year and Date: 2011-10-21
• [Presentation] オートファジーによる細胞内品質管理と腫瘍抑制作用 (2011)
  • Author(s): 水島昇
  • Organizer: 第70回日本癌学会学術総会
  • Place of Presentation: 名古屋(招待講演)
  • Year and Date: 2011-10-03
• [Presentation] Autophagy prevents spontaneous tumor development in the liver (2011)
  • Author(s): Noboru Mizushima
  • Organizer: 第70回日本癌学会学術総会
  • Place of Presentation: 名古屋(招待講演)
  • Year and Date: 2011-10-03
• [Presentation] オートファジーの生理的役割 (2011)
  • Author(s): 水島昇
  • Organizer: 動脈硬化Update2011
  • Place of Presentation: 神戸(招待講演)
  • Year and Date: 2011-09-03
• [Presentation] マウスを用いたオートファジー長期不全による影響の評価 (2011)
  • Author(s): 水島昇
  • Organizer: 第11回日本抗加齢医学会総会
  • Place of Presentation: 京都(受賞講演)
  • Year and Date: 2011-05-28
• [Presentation] Quality control of proteins and organelles by autophagy (2011)
  • Author(s): Noboru Mizushima
  • Organizer: IPSEN foundation symposium "Protein Quality Control in Neurodegenerative Diseases"
  • Place of Presentation: Paris, France(招待講演)
  • Year and Date: 2011-05-09
• [Presentation] Physiological role of autophagy in protein and organelle turnover (2011)
  • Author(s): Noboru Mizushima
  • Organizer: LSI 10th Annual Symposium "Autophagy in Health & Disease"
  • Place of Presentation: Ann Arbor, MI, USA(招待講演)
  • Year and Date: 2011-05-05
• [Presentation] オートファジーの生理的役割 (2011)
  • Author(s): 水島昇
  • Organizer: 日本分子生物学会第11回春季シンポジウム
  • Place of Presentation: 金沢(招待講演)
• [Presentation] Role of autophagy in protein metabolism and tumor suppression (2011)
  • Author(s): Noboru Mizushima
  • Organizer: The 76th Cold Spring Harbor Symposium "Metabolism & Disease"
  • Place of Presentation: Cold Spring Harbor, NY, USA(招待講演)
• [Presentation] Autophagy : the cytoplasm-to-lysosome pathway (2011)
  • Author(s): Noboru Mizushima
  • Organizer: 2011 Tokyo Meeting on Lysosomal Storage Disease Screening
  • Place of Presentation: 東京(招待講演)
• [Presentation] Molecular machinery and regulation of autophagy (2011)
  • Author(s): Noboru Mizushima
  • Organizer: The EMBO Meeting 2011
  • Place of Presentation: Vienna, Austria(招待講演)
• [Presentation] Mammalian Atg2 protein (2011)
  • Author(s): Noboru Mizushima
  • Organizer: The second Japan-Sino autophagy symposium
  • Place of Presentation: Hayama(招待講演)
• [Presentation] Mammalian Atg proteins in autophagosome formation (2011)
  • Author(s): Noboru Mizushima
  • Organizer: EMBO conference series : Autophagy in health and disease
  • Place of Presentation: Israel(招待講演)
• [Presentation] Formation of autophagosome and mitophagosome (2011)
  • Author(s): Noboru Mizushima
  • Organizer: Zing conference on autophagy
  • Place of Presentation: Cancun, Mexico(招待講演)
• [Presentation] Hierarchical Relationships among Mammalian Atg Proteins (2011)
  • Author(s): Noboru Mizushima
  • Organizer: Keystone symposium on Autophagy
  • Place of Presentation: Whistler, Canada
• [Presentation] どんどん入れ替わっている私達の体～新鮮さを保つ秘密～ (2010)
  • Author(s): 水島昇
  • Organizer: BMB2010(第33回日本分子生物学会年会・第83回日本生化学会大会合同大会)・市民公開講座「広がる生命科学の世界-体作りから病気の克服まで-」
  • Place of Presentation: 東京
  • Year and Date: 2010-12-11
• [Presentation] タンパク質のリサイクルと私たちの体の調子を整えるしくみについて (2010)
  • Author(s): 反町洋之
  • Organizer: 第37回三省堂サイエンスカフェ〔日本農芸化学会シリーズ(12)〕
  • Place of Presentation: 東京
  • Year and Date: 2010-10-23
• [Presentation] Regulation and Molecular Basis for Membrane Dynamics of Microautophagy (2010)
  • Author(s): Yasuyoshi Sakai
  • Organizer: The 1st Sino-Japan Autophagy Symposium
  • Place of Presentation: Xi'an, China
  • Year and Date: 2010-10-15
• [Presentation] Vacuole dynamics during microautophagy (2010)
  • Author(s): Yasuyoshi Sakai
  • Organizer: Swiss Yeast Meeting
  • Place of Presentation: Fribourg, Switzerland
  • Year and Date: 2010-09-06
• [Presentation] 鈴木先生の哲学とカルパイン (2010)
  • Author(s): 反町洋之
  • Organizer: 鈴木紘一先生メモリアルシンポジウム
  • Place of Presentation: 東京
  • Year and Date: 2010-07-06
• [Presentation] Recruitment of PI4-kinase from the Golgi apparatus to PAS (2010)
  • Author(s): Yasuyoshi Sakai
  • Organizer: Gordon research conference on "Autophagy in Stress, Development and Disease
  • Place of Presentation: Barga, Italy
  • Year and Date: 2010-04-27
• [Presentation] タンパク質のリサイクル-私たちの体にある「エコ」なシステムについて- (2010)
  • Author(s): 反町洋之
  • Organizer: 第29回東京都臨床医学総合研究所公開講演会
  • Place of Presentation: 東京
  • Year and Date: 2010-04-14
• [Presentation] Physiological roles of autophagy: Lessons from autophagy deficient mouse models. (2010)
  • Author(s): Noboru Mizushima.
  • Organizer: The American Society of Cell Biology 50th Annual Meeting.
  • Place of Presentation: Philadelphia, USA.
• [Presentation] Linear polyubiquitination : a new regulator of NF-κB signaling. (2010)
  • Author(s): Kazuhiro Iwai.
  • Organizer: Banbury Center meetings, Signaling through ubiquitin.The Banbury Center, Cold Spring Harbor Laboratory
  • Place of Presentation: New York, USA.
• [Presentation] Physiological role of autophagy and its regulation mechanism. (2010)
  • Author(s): Noboru Mizushima.
  • Organizer: OzBio2010/12th IUBMB2010.
  • Place of Presentation: Melbourne, Australia.
• [Presentation] Unique functions of mammalian unconventional calpains (2010)
  • Author(s): Hiroyuki Sorimachi.
  • Organizer: FASEB Summer Research Conferences-The Biology of Calpains in Health & Disease
  • Place of Presentation: Arizona, U.S.A.
• [Presentation] Recruitment of PI4-kinase from the Golgi appratus to PAS Gordon conference "Autophagy in Stress, Development and Disease". (2010)
  • Author(s): Yasuyoshi Sakai.
  • Organizer: Il Ciocco, Hotel and Resourt
  • Place of Presentation: Lucca, Italy
• [Presentation] Autophagosome formation and early Atg proteins (2010)
  • Author(s): Eisuke Itakura
  • Organizer: Gordon Research Conference "Autophagy in stress, development and disease"
  • Place of Presentation: Barga, Italy
• [Presentation] Physiological roles of autophagy in mammals (2010)
  • Author(s): Noboru Mizushima
  • Organizer: EMBO Worshop Proteolysis and Neurodegeneration/5th INPROTEOLYS meeting
  • Place of Presentation: Madrid, Spain
• [Presentation] Physiological role of autophagy and its regulation mechanism (2010)
  • Author(s): Noboru Mizushima
  • Organizer: OzBio2010/12th IUBMB2010
  • Place of Presentation: Melbourne, Australia
• [Presentation] Role of autophagy in tumorigenesis (2010)
  • Author(s): Noboru Mizushima
  • Organizer: The 1st Sino-Japan Autophagy Symposium
  • Place of Presentation: Xi'an, China
• [Presentation] Physiological roles of autophagy : Lessons from autophagy deficient mouse models (2010)
  • Author(s): Noboru Mizushima
  • Organizer: The American Society of Cell Biology 50th Annual Meeting
  • Place of Presentation: Philadelphia、USA
• [Presentation] p62 recruitment to autophagosomes (2010)
  • Author(s): Noboru Mizushima
  • Organizer: NCI Workshop on Autophagy in Cancer Initiation and Progression
  • Place of Presentation: Bethesda、USA
• [Presentation] Lessons from Autophagy Deficient Mouse Models (2010)
  • Author(s): Noboru Mizushima
  • Organizer: Keystone symposium "Cell Death Pathways/Metabolism and Cancer Progression"
  • Place of Presentation: Vancouver, Canada
• [Presentation] Molecular mechanism of autophagy induction and autophagosome formation in mammalian cells. (2009)
  • Author(s): Noboru Mizushima.
  • Organizer: The EMBO Conference on Autophagy : Cell Biology, Physiology and Pathology.
  • Place of Presentation: Monte Verita, Switzerland.
  • Year and Date: 2009-10-19
• [Presentation] Molecular mechanism of autophagy regulation in mammalian cells. (2009)
  • Author(s): Noboru Mizushima.
  • Organizer: Gordon conference "Stress Proteins In Growth, Development & Disease".
  • Place of Presentation: Andover, USA.
• [Presentation] Role of autophagy in protein metabolism and generation of an autophagy-regulatable cell line. (2007)
  • Author(s): Noboru Mizushima.
  • Organizer: 32nd FEBS Congress
  • Place of Presentation: Molecular Machines. Vienna.
• [Presentation] Physiological Role of Autophagy in Protein Turnover. (2007)
  • Author(s): Noboru Mizushima.
  • Organizer: Keystone symposium "Autophagy in Health and Disease".
  • Place of Presentation: Monterey.
• [Book] 細胞が自分を食べるオートファジーの謎 (2011)
  • Author(s): 水島昇
  • Total Pages: 215
  • Publisher: PHPサイエンス・ワールド新書
• [Book] 糖尿病イラストレイテッド「代謝とオートファジー」 (2011)
  • Author(s): 久万亜紀子
  • Publisher: 羊土社(印刷中)
• [Book] がん生物学イラストレイテッド「オートファジー」 (2011)
  • Author(s): 西村多喜
  • Publisher: 羊土社
• [Book] Conjugation and Deconjugation of Ubiquitin Family Modifiers (2010)
  • Author(s): Iwai K.
  • Total Pages: 272
  • Publisher: Groettrup, M.eds Landes Biosciences
• [Book] Transgenic models of autophagy (2006)
  • Author(s): Mizushima N
  • Publisher: Wiley-VCH
• [Book] Current Protocols in Cell(Biology Bonifacino J, Dasso M, Lippincott-Schwartz J, Harford J, Yamada K, Bonafacino J, eds. John Wiley and Sons) (2006)
  • Author(s): Lorick, K., Yang, Y., Jensen, J., Iwai, K., Weissman, A.M.
  • Publisher: Studies of the ubiquitin proteasome system. Units 15.9 Sections 1-12.
• [Remarks]
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• [Remarks] 研究代表者HP
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• [Remarks] 本特定領域のホームページ
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• [Patent(Industrial Property Rights)] 新規なユビキチンリガーゼおよびその利用 (2010)
  • Inventor(s): 岩井一宏
  • Industrial Property Rights Holder: 大阪大学
  • Filing Date: 2010-08-06
  • Overseas