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Multimode autophagy

Administrative Group

Project AreaMultimode autophagy: Diverse pathways and selectivity
Project/Area Number 19H05705
Research Category

Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)

Allocation TypeSingle-year Grants
Review Section Biological Sciences
Research InstitutionJuntendo University

Principal Investigator

Komatsu Masaaki  順天堂大学, 大学院医学研究科, 教授 (90356254)

Project Period (FY) 2019-06-28 – 2024-03-31
Project Status Completed (Fiscal Year 2023)
Budget Amount *help
¥122,980,000 (Direct Cost: ¥94,600,000、Indirect Cost: ¥28,380,000)
Fiscal Year 2023: ¥11,180,000 (Direct Cost: ¥8,600,000、Indirect Cost: ¥2,580,000)
Fiscal Year 2022: ¥11,180,000 (Direct Cost: ¥8,600,000、Indirect Cost: ¥2,580,000)
Fiscal Year 2021: ¥21,580,000 (Direct Cost: ¥16,600,000、Indirect Cost: ¥4,980,000)
Fiscal Year 2020: ¥11,180,000 (Direct Cost: ¥8,600,000、Indirect Cost: ¥2,580,000)
Fiscal Year 2019: ¥67,860,000 (Direct Cost: ¥52,200,000、Indirect Cost: ¥15,660,000)
Keywordsオートファジー / マルチモードオートファジー / マクロオートファジー / ミクロオートファジー / 膜透過型オートファジー / 細胞膜分解 / 選択的オートファジー / 細胞膜オートファジー
Outline of Research at the Start

多様な経路で実行されるオートファジーやそれらによる選択的基質分解(マルチモードオートファジーと定義)は相互に関連し、細胞の環境適応、恒常性、分化などの幅広い細胞機能を制御すると考えられる。本研究では、マルチモードオートファジー領域における計画研究および公募研究の推進(企画調整)、支援、評価、そして若手研究者の育成、海外研究者との多岐にわたる共同研究のサポートを行い、オートファジー研究を新しいステージへ導き、次世代に発展させる。また同時に、それらの成果を広く社会に発信するための領域ホームページやフォーラムを整備する。

Outline of Final Research Achievements

The website (https://proteolysis.jp/multimode_autophagy/) was updated as needed to promote the autophagy field. The Autophagy Forum (https://proteolysis.jp/a_forum/), a website introducing published papers, has introduced 224 papers since its establishment, contributing to the rapid exchange of information within the field. The general group meetings were held to discuss issues and plans for the promotion of the project, and contributed to the smooth operation of the project. Held annual meetings of the group and young researchers, contributing to the development of young researchers, exchange of researchers, and promotion of joint research in the field. Held the 10th International Symposium on Autophagy to promote a sense of presence in Japan autophagy research.

Academic Significance and Societal Importance of the Research Achievements

マルチモードオートファジーは細胞内で膜が新規に作られたり、特殊な形態変化を伴って分解に至ったりというような複雑で多様な膜動態を含む。したがって、本研究領域から明らかになったマルチモードオートファジーの分子基盤を足がかりにタンパク質と膜脂質が織りなす細胞機能が解明されれば、これまでにない細胞生物学の新基軸が生まれると考えられる。さらに、本研究領域から明らかになってきた多様な選択的オートファジーの作動原理や生理機能はがんや神経変性疾患といったオートファジー障害関連疾患の予防や治療に結びつくことが期待される。

Report

(6 results)
  • 2023 Annual Research Report   Final Research Report ( PDF )
  • 2022 Annual Research Report
  • 2021 Annual Research Report
  • 2020 Annual Research Report
  • 2019 Annual Research Report
  • Research Products

    (43 results)

All 2024 2023 2022 Other

All Journal Article (16 results) (of which Int'l Joint Research: 8 results,  Peer Reviewed: 16 results,  Open Access: 15 results) Presentation (19 results) (of which Int'l Joint Research: 10 results,  Invited: 17 results) Remarks (6 results) Funded Workshop (2 results)

  • [Journal Article] The UFM1 system: Working principles, cellular functions, and pathophysiology2024

    • Author(s)
      Komatsu Masaaki、Inada Toshifumi、Noda Nobuo N.
    • Journal Title

      Molecular Cell

      Volume: 84 Issue: 1 Pages: 156-169

    • DOI

      10.1016/j.molcel.2023.11.034

    • Related Report
      2023 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Vault-phagy: a phase-separation-mediated selective autophagy of vault, a non-membranous organelle2023

    • Author(s)
      Kurusu Reo、Morishita Hideaki、Komatsu Masaaki
    • Journal Title

      Autophagy

      Volume: 20 Issue: 2 Pages: 441-442

    • DOI

      10.1080/15548627.2023.2266996

    • Related Report
      2023 Annual Research Report
    • Peer Reviewed
  • [Journal Article] p62 bodies: cytosolic zoning by phase separation2023

    • Author(s)
      Kurusu Reo、Morishita Hideaki、Komatsu Masaaki
    • Journal Title

      The Journal of Biochemistry

      Volume: 175 Issue: 2 Pages: 141-146

    • DOI

      10.1093/jb/mvad089

    • Related Report
      2023 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] ATG9A supports Chlamydia trachomatis infection via autophagy-independent mechanisms2023

    • Author(s)
      Michitaka Suzuki, Tomoko Funakoshi, Keigo Kumagai, Masaaki Komatsu, Satoshi Waguri
    • Journal Title

      Microbiology Spectrum

      Volume: 11(5) Issue: 5

    • DOI

      10.1128/spectrum.02774-23

    • Related Report
      2023 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Mechanistic insights into the roles of the UFM1 E3 ligase complex in ufmylation and ribosome-associated protein quality control2023

    • Author(s)
      Ishimura Ryosuke、Ito Sota、Mao Gaoxin、Komatsu-Hirota Satoko、Inada Toshifumi、Noda Nobuo N.、Komatsu Masaaki
    • Journal Title

      Science Advances

      Volume: 9 Issue: 33

    • DOI

      10.1126/sciadv.adh3635

    • Related Report
      2023 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Phosphorylation of phase‐separated p62 bodies by ULK1 activates a redox‐independent stress response2023

    • Author(s)
      Ikeda Ryo、Noshiro Daisuke、Morishita Hideaki、Takada Shuhei、Kageyama Shun、Fujioka Yuko、Funakoshi Tomoko、Komatsu‐Hirota Satoko、Arai Ritsuko、Ryzhii Elena、Abe Manabu、Koga Tomoaki、Motohashi Hozumi、Nakao Mitsuyoshi、Sakimura Kenji、Horii Arata、Waguri Satoshi、Ichimura Yoshinobu、Noda Nobuo N、Komatsu Masaaki
    • Journal Title

      The EMBO Journal

      Volume: 42 Issue: 14

    • DOI

      10.15252/embj.2022113349

    • Related Report
      2023 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Integrated proteomics identifies p62-dependent selective autophagy of the supramolecular vault complex2023

    • Author(s)
      Kurusu Reo、Fujimoto Yuki、Morishita Hideaki、Noshiro Daisuke、Takada Shuhei、Yamano Koji、Tanaka Hideaki、Arai Ritsuko、Kageyama Shun、Funakoshi Tomoko、Komatsu-Hirota Satoko、Taka Hikari、Kazuno Saiko、Miura Yoshiki、Koike Masato、Wakai Toshifumi、Waguri Satoshi、Noda Nobuo N.、Komatsu Masaaki
    • Journal Title

      Developmental Cell

      Volume: - Issue: 13 Pages: 1189-1205

    • DOI

      10.1016/j.devcel.2023.04.015

    • Related Report
      2023 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Cathelicidin LL-37 activates human keratinocyte autophagy through the P2X7, mechanistic target of rapamycin, and MAPK pathways2023

    • Author(s)
      Ikutama R、Peng G、Tsukamoto S、Umehara Y、Trujillo-Paez JV、Yue H、Nguyen HLT、Takahashi M、Kageyama S、Komatsu M、Okumura K、Ogawa H、Ikeda Sh、Niyonsaba F
    • Journal Title

      Journal of Investigative Dermatology

      Volume: 143 Issue: 5 Pages: 751-761

    • DOI

      10.1016/j.jid.2022.10.020

    • Related Report
      2023 Annual Research Report 2022 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] The UFM1 system regulates ER-phagy through the ufmylation of CYB5R3.2022

    • Author(s)
      Ishimura R, El-Gowily AH, Noshiro D, Komatsu-Hirota S, Ono Y, Shindo M, Hatta T, Abe M, Uemura T, Lee-Okada HC, Mohamed TM, Yokomizo T, Ueno T, Sakimura K, Natsume T, Sorimachi H, Inada T, Waguri S, Noda NN, Komatsu M.
    • Journal Title

      Nature Communications

      Volume: 13 Issue: 1 Pages: 7857-7857

    • DOI

      10.1038/s41467-022-35501-0

    • Related Report
      2022 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Lack of Hepatic Autophagy Promotes Severity of Liver Injury but Not Steatosis2022

    • Author(s)
      Ding WX, Ni HM, Waguri S, Komatsu M.
    • Journal Title

      J Hepatol.

      Volume: 77(5) Issue: 5 Pages: 1458-1459

    • DOI

      10.1016/j.jhep.2022.05.015

    • Related Report
      2022 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Human β-defensin-3 attenuates atopic dermatitis-like inflammation through autophagy activation and the aryl hydrocarbon receptor signaling pathway2022

    • Author(s)
      Peng G、Tsukamoto S、Ikutama R、Nguyen HLT、Umehara Y、Trujillo-Paez JV、Yue H、Takahashi M、Ogawa T、Kishi R、Tominaga M、Takamori K、Kitaura J、Kageyama S、Komatsu M、Okumura K、Ogawa H、Ikeda S、Niyonsaba F
    • Journal Title

      Journal of Clinical Investigation

      Volume: 132 Issue: 17

    • DOI

      10.1172/jci156501

    • Related Report
      2022 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Central role for p62/SQSTM1 in the elimination of toxic tau species in a mouse model of tauopathy2022

    • Author(s)
      Ono Maiko、Komatsu Masaaki、Ji Bin、Takado Yuhei、Shimojo Masafumi、Minamihisamatsu Takeharu、Warabi Eiji、Yanagawa Toru、Matsumoto Gen、Aoki Ichio、Kanaan Nicholas M.、Suhara Tetsuya、Sahara Naruhiko、Higuchi Makoto
    • Journal Title

      Aging Cell

      Volume: 21 Issue: 7

    • DOI

      10.1111/acel.13615

    • Related Report
      2022 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Impaired GATE16-mediated exocytosis in exocrine tissues causes Sj?gren’s syndrome-like exocrinopathy2022

    • Author(s)
      Suzuki Akiko、Iwaya Chihiro、Ogata Kenichi、Yoshioka Hiroki、Shim Junbo、Tanida Isei、Komatsu Masaaki、Tada Norihiro、Iwata Junichi
    • Journal Title

      Cellular and Molecular Life Sciences

      Volume: 79 Issue: 6 Pages: 307-307

    • DOI

      10.1007/s00018-022-04334-x

    • Related Report
      2022 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Deficient Autophagy in Microglia Aggravates Repeated Social Defeat Stress-Induced Social Avoidance2022

    • Author(s)
      Sakai Mai、Yu Zhiqian、Hirayama Ryo、Nakasato Masa、Kikuchi Yoshie、Ono Chiaki、Komatsu Hiroshi、Nakanishi Miharu、Yoshii Hatsumi、Stellwagen David、Furuyashiki Tomoyuki、Komatsu Masaaki、Tomita Hiroaki
    • Journal Title

      Neural Plasticity

      Volume: 2022 Pages: 1-13

    • DOI

      10.1155/2022/7503553

    • Related Report
      2022 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Role of autophagy in liver diseases2022

    • Author(s)
      Morishita Hideaki, Komatsu Masaaki
    • Journal Title

      Current Opinion in Physiology

      Volume: 30 Pages: 100594-100594

    • Related Report
      2022 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] p62 bodies: phase separation, NRF2 activation, and selective autophagic degradation2022

    • Author(s)
      Komatsu M.
    • Journal Title

      IUBMB Life

      Volume: 74(12) Issue: 12 Pages: 1200-1208

    • DOI

      10.1002/iub.2689

    • Related Report
      2022 Annual Research Report
    • Peer Reviewed / Open Access
  • [Presentation] p62:液ー液相分離、生理作用、オートファジー分解2024

    • Author(s)
      小松雅明
    • Organizer
      東大医科研オートファジーミニシンポジウム
    • Related Report
      2023 Annual Research Report
    • Invited
  • [Presentation] UFM1システムによる翻訳品質管理機構2024

    • Author(s)
      小松雅明
    • Organizer
      第二回タンパク質シンポジウム
    • Related Report
      2023 Annual Research Report
    • Invited
  • [Presentation] Phase-separation and autophagy co-creating stress response2023

    • Author(s)
      Masaaki Komatsu
    • Organizer
      KEYSTONE SYMPOSIA on Molecular and Cellular Biology Autophagy and Disease
    • Related Report
      2023 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Phase-separation and autophagy co-creating stress response2023

    • Author(s)
      Masaaki Komatsu
    • Organizer
      The Cancer Research Centre of Marseille Seminar
    • Related Report
      2023 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Phase-separation and autophagy co-creating stress response2023

    • Author(s)
      Masaaki Komatsu
    • Organizer
      1th Scientific Days on Autophagy (Plenary lecture)
    • Related Report
      2023 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Phase-separation and autophagy co-creating stress response2023

    • Author(s)
      Masaaki Komatsu
    • Organizer
      Institut NeuroMyoGene Seminar
    • Related Report
      2023 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Phase-separation and autophagy co-creating stress response2023

    • Author(s)
      小松雅明
    • Organizer
      第82回日本癌学会学術総会 特別シンポジウム
    • Related Report
      2023 Annual Research Report
    • Invited
  • [Presentation] 選択的オートファジーと液ー液相分離2023

    • Author(s)
      小松雅明
    • Organizer
      ERATO 水島細胞内分解ダイナミクスプロジェクト シンポジウム
    • Related Report
      2023 Annual Research Report
    • Invited
  • [Presentation] 選択的オートファジーと液ー液相分離2023

    • Author(s)
      小松雅明
    • Organizer
      第17回パーキンソン病・運動障害疾患コングレス
    • Related Report
      2023 Annual Research Report
    • Invited
  • [Presentation] Phase-separated p62 body: formation, biological role and degradation2023

    • Author(s)
      小松雅明
    • Organizer
      第23回日本蛋白質学会年会
    • Related Report
      2023 Annual Research Report
  • [Presentation] 選択的オートファジー:p62液滴の形成、生理作用、分解2023

    • Author(s)
      小松雅明
    • Organizer
      第89回日本生化学会東北支部例会・特別講演
    • Related Report
      2023 Annual Research Report
    • Invited
  • [Presentation] Selective autophagy of phase-separated p62: from molecular mechanism to pathophysiology2023

    • Author(s)
      Masaaki Komatsu
    • Organizer
      Seoul National University Seminar
    • Related Report
      2023 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Selective autophagy of phase-separated p62: from molecular mechanism to pathophysiology2023

    • Author(s)
      Masaaki Komatsu
    • Organizer
      KSBMB (Korean Society for Biochemistry and Molecular Biology) International Conference 2023
    • Related Report
      2023 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Selective autophagy of phase-separated p62: from molecular mechanism to pathophysiology2023

    • Author(s)
      Masaaki Komatsu
    • Organizer
      Chungnam National University School of Medicine Seminar
    • Related Report
      2023 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] 選択的オートファジー 分子から病態まで2022

    • Author(s)
      小松雅明 選択的オートファジー 分子から病態まで 日本Cell Death学会 特別講演
    • Organizer
      日本Cell Death学会 特別講演
    • Related Report
      2022 Annual Research Report
    • Invited
  • [Presentation] Vault-phagy: selective autophagy of large cytoplasmic ribonucleoprotein particles, Vault2022

    • Author(s)
      Masaaki Komatsu
    • Organizer
      EMBO Meeting
    • Related Report
      2022 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Physiological importance of p62-phosphorylation in NRF2-activation2022

    • Author(s)
      Masaaki Komatsu
    • Organizer
      Frankfurt Conference on Quality Control in life Processes
    • Related Report
      2022 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] UFM1システムによるER-phagy制御ーその異常と遺伝性脳症ー2022

    • Author(s)
      石村亮輔、小松雅明
    • Organizer
      第64回日本小児神経学会学術集会
    • Related Report
      2022 Annual Research Report
    • Invited
  • [Presentation] Proteomic approaches to purified p62-bodies and selective autophagy-deficient mice identify a novel substrate for p62-mediated selective autophagy2022

    • Author(s)
      Hideaki Morishita*, Reo Kurusu*, Yuki Fujimoto*, Shuhei Takada, Masaaki Komatsu
    • Organizer
      10th International Symposium on Autophagy
    • Related Report
      2022 Annual Research Report
    • Int'l Joint Research
  • [Remarks] 順天堂大学大学院医学研究科 器官・細胞生理

    • URL

      https://www.juntendo.ac.jp/graduate/laboratory/labo/kikan_saibou/

    • Related Report
      2023 Annual Research Report
  • [Remarks] 文部科学省 科研費 新学術領域研究 マルチモードオートファジー

    • URL

      https://proteolysis.jp/multimode_autophagy/

    • Related Report
      2023 Annual Research Report
  • [Remarks] マルチモードオートファジー 多彩な経路と選択性が織り成す自己分解系の理解

    • URL

      https://proteolysis.jp/multimode_autophagy/

    • Related Report
      2022 Annual Research Report
  • [Remarks] 順天堂大学医学部 生理学第二講座

    • URL

      https://www.juntendo.ac.jp/graduate/laboratory/labo/kikan_saibou/

    • Related Report
      2022 Annual Research Report
  • [Remarks] 順天堂大学医学部生理学第二講座

    • URL

      https://www.juntendo.ac.jp/graduate/laboratory/labo/kikan_saibou/

    • Related Report
      2020 Annual Research Report
  • [Remarks] 文部科学省 新学術領域研究 マルチモードオートファジー 多彩な経路と選択性が織り成す自己分解系の理解

    • URL

      http://proteolysis.jp/multimode_autophagy/

    • Related Report
      2020 Annual Research Report 2019 Annual Research Report
  • [Funded Workshop] 10th International Symposium on Autophagy2022

    • Related Report
      2022 Annual Research Report
  • [Funded Workshop] 10th International Symposium on Autophagy2022

    • Related Report
      2021 Annual Research Report

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Published: 2019-07-04   Modified: 2025-01-30  

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