Signaling Functions of Reactive Oxygen Species

• Project Area: Signaling functions of reactive oxygen species
• Project/Area Number: 20117001
• Research Category: Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)
• Allocation Type: Single-year Grants
• Review Section: Biological Sciences
• Research Institution: Tohoku University (2013); Kumamoto University (2008-2012)
• Principal Investigator: AKAIKE Takaaki 東北大学, 医学(系)研究科(研究院), 教授 (20231798)
• Co-Investigator(Kenkyū-buntansha): SUMIMOTO Hideki 九州大学, 医学研究院, 教授 (30179303) ; UCHIDA Koji 名古屋大学, 生命農学研究科, 教授 (40203533) ; MATSUMOTO Akio 千葉大学, 医学研究科, 准教授 (60437308) ; URANO Yasuteru 東京大学, 医学研究科, 教授 (20292956) ; ARIMOTO Hirokazu 東北大学, 生命科学研究科, 教授 (60262789) ; ITOH Ken 弘前大学, 医学研究科, 教授 (10323289)
• Co-Investigator(Renkei-kenkyūsha): SHIMOKAWA Hiroaki 東北大学, 医学系研究科, 教授 (00235681) ; TSUTSUI Hiroyuki 北海道大学, 医学研究科, 教授 (70264017) ; UEHARA Takashi 岡山大学, 医歯薬学研究科, 教授 (00261321) ; KAMATA Hideaki 広島大学, 医歯薬学総合研究科, 准教授 (10233925) ; NISHIDA Motohiro 九州大学, 薬学研究院, 准教授 (90342641)
• Project Period (FY): 2008-11-13 – 2014-03-31
• Project Status: Completed (Fiscal Year 2013)
• Budget Amount: ¥58,500,000 (Direct Cost: ¥45,000,000、Indirect Cost: ¥13,500,000); Fiscal Year 2013: ¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000); Fiscal Year 2012: ¥16,380,000 (Direct Cost: ¥12,600,000、Indirect Cost: ¥3,780,000); Fiscal Year 2011: ¥16,380,000 (Direct Cost: ¥12,600,000、Indirect Cost: ¥3,780,000); Fiscal Year 2010: ¥7,020,000 (Direct Cost: ¥5,400,000、Indirect Cost: ¥1,620,000); Fiscal Year 2009: ¥7,020,000 (Direct Cost: ¥5,400,000、Indirect Cost: ¥1,620,000); Fiscal Year 2008: ¥7,800,000 (Direct Cost: ¥6,000,000、Indirect Cost: ¥1,800,000)
• Keywords: 活性酸素 / シグナル伝達 / ケミカルバイオロジー / 酸化ストレス / 生理活性 / 生体分子

Research Abstract

活性酸素は生体分子に非特異的な化学損傷をもたらす単なる毒性因子ではなく、シグナル分子として生体内で様々な役割を担っていることが明らかになってきた。本領域研究は、化学と生物系が融合したケミカルバイオロジーの新たな視点から、活性酸素によるシグナル伝達研究を展開することにより、多彩な生命現象と疾患病態に関与している活性酸素の生理機能の解明と生物種に普遍的に発現されている活性酸素シグナルの統合的理解を目指して発足した。本年度は、領域研究にて得られた成果を国内外に情報発信することを目的とした。具体的には、下記の学会での共催として、領域メンバーおよび招待演者における講演をおこなった。（１）ジョイントシンポジウム「生体ストレス応答：酸素毒から環境汚染物質まで」（領域メンバー５名、海外招待演者１名）（平成２５年７月１２日、熊本、日本生体防御学会との共催）、（２）東北医学会（海外招待演者１名、平成２６年３月２０日、仙台）。本領域研究で取扱う「活性酸素シグナル」は、基礎生物学、農学（植物学）、医学生物学を含めた生命科学の幅広い分野に関係している。また、活性酸素の生理機能の解明なしには、活性酸素の制御異常がもたらす疾病である、メタボリックシンドローム、感染・炎症、老化、発がんなどの病態解明と予防対策、治療戦略は確立できない。したがって、本領域研究で得られた成果は、今後益々重要となる「活性酸素シグナル」をキーワードとした異分野融合型プロジェクトの形成推進に大きく資するものと期待される。

Current Status of Research Progress

Reason

25年度が最終年度であるため、記入しない。

Strategy for Future Research Activity

25年度が最終年度であるため、記入しない。

Research Products

• [Journal Article] Reactive cysteine persulfides and S-polythiolation regulate oxidative stress and redox signaling. (2014)
  • Author(s): Ida T, Sawa T, Ihara H, Tsucr iya Y, Watanabe Y, Kumagai Y, Suematsu M, Motohashi H, Fujii S. Matsunaga T, Yamamoto M, Ono K, Devarie-Baez N O, Xian M, Fukuto J M, Akaike T.
  • Journal Title: Proc. Natl. Acad. Sci. USA Volume: (印刷中) Issue: 21 Pages: 7606-7611
  • DOI: 10.1073/pnas.1321232111
  • Peer Reviewed / Open Access
• [Journal Article] Promotion of atherosclerosis by Helicobacter cinaedi infection that involves macrophage-driven proinflammatory responses. (2014)
  • Author(s): Khan S, Rahman H N A, Okamoto T, Matsunaga T, Fujiwara Y, Sawa T, Yoshitake J, Ono K, Ahmed K A, Rahaman M d M, Oyama K, Takeya M, Ida T, Kitamura Y, Fujii S, Akaike T.
  • Journal Title: Sci. Rep. Volume: (印刷中) Issue: 1 Pages: 4680-4680
  • DOI: 10.1038/srep04680
  • NAID: 120005649608
  • Peer Reviewed / Open Access
• [Journal Article] S-Guanylation proteomics for redox-based mitochondrial signaling. (2014)
  • Author(s): Rahaman MM, Sawa T, Ahtesh am AK, Khan S, Inoue H, Irie A. Fujii S, and Akaike T.
  • Journal Title: Antioxid. Redox Signal. Volume: 20 Issue: 2 Pages: 295-307
  • DOI: 10.1089/ars.2012.4606
  • Peer Reviewed / Open Access
• [Journal Article] Redox signal regulation via nNOS phosphorylation at Ser847 in PC12 cells and rat cerebellar granule neurons. (2014)
  • Author(s): Kasamats S, Watanabe Y, Sawa T, Akaike T, Ihara H.
  • Journal Title: Biochem. J. Volume: 459 Issue: 2 Pages: 251-263
  • DOI: 10.1042/bj20131262
  • Peer Reviewed
• [Journal Article] SIRT7 controls hepatic lipid metabolism by regulating the ubiquitin-proteasome pathway. (2014)
  • Author(s): Yoshizawa T, Karim Md. F, Sato Y, Senokuchi T, Miyata K, Fukuda T, Go C, Tasaki M, Uchimura K, Kadomatsu T, Tian Z, Smolka C, Sawa T, Kakeya M, Tomizawa K, Ando Y, Araki E, Akaike T, Braun T, Oike Y, Bober E, Yamagata K.
  • Journal Title: Cell Metab. Volume: 9 Issue: 4 Pages: 712-721
  • DOI: 10.1016/j.cmet.2014.03.006
  • Peer Reviewed / Open Access
• [Journal Article] Endogenous nitrated nucleotide is a key mediator of autophagy and innate defense against bacteria. (2013)
  • Author(s): Ito C, Saito Y, Nozawa T, Fujii S, Sawa T, Inoue H, Matsunaga T, Khan S, Akashi S, Hashimoto R, Aikawa C, Takahashi E, Sagara H, Komatsu M, Tanaka K, Akaike T, Nakagawa I, Arimoto H.
  • Journal Title: Mol. Cell Volume: 52 Issue: 6 Pages: 794-804
  • DOI: 10.1016/j.molcel.2013.10.024
  • Peer Reviewed / Open Access
• [Journal Article] Regulation of redox signaling by an electrophilic cyclic nucleotide. (2013)
  • Author(s): Akaike T, Nishida M and Fujii S.
  • Journal Title: J. Biochem. Volume: 153 Issue: 2 Pages: 131-138
  • DOI: 10.1093/jb/mvs145
  • Peer Reviewed
• [Journal Article] Redox signaling by 8-nitro-cyclic guanosine monophosphate : nitric oxide- and reactive oxygen species-derived electrophilic messenger (2013)
  • Author(s): Fujii S and Akaike T.
  • Journal Title: Antioxid. Redox Signal. Volume: 19 Issue: 11 Pages: 1236-1246
  • DOI: 10.1089/ars.2012.5067
  • Peer Reviewed
• [Journal Article] Formation, signaling functions, and metabolisms of nitrated cyclic nucleotide. (2013)
  • Author(s): Sawa T, Ihara H, Ida T, Fujii S, Nishida M and Akaike T.
  • Journal Title: Nitric Oxide Volume: 34 Pages: 10-18
  • DOI: 10.1016/j.niox.2013.04.004
  • Peer Reviewed
• [Journal Article] Inhibition of H3K18 deacetylation of SIRT7 by Myb-binding protein la (Mybbpla) (2013)
  • Author(s): Karim Md F, Yoshizawa T, Sato Y, Sawa T, Tomizawa K, A kaike T and Yamagata K.
  • Journal Title: Biochem. Biophys. Res. Commun. Volume: 441 Issue: 1 Pages: 157-163
  • DOI: 10.1016/j.bbrc.2013.10.020
  • Peer Reviewed
• [Journal Article] Fluorescent probes for live cell imaging of endogenous guanine nitration (2013)
  • Author(s): Saito Y, Ito C, Fujii S, Sawa T, Akaike T and Arimoto H.
  • Journal Title: Chembiochem. Volume: 14 Issue: 9 Pages: 1068-1071
  • DOI: 10.1002/cbic.201300129
  • Peer Reviewed
• [Journal Article] Nitrated cyclic GMP modulates guard cell signaling in Arabidopsis (2013)
  • Author(s): Joudoi T, Hatakeyama T, Maeda T, Akaike T, Sawa T and Iwai S.
  • Journal Title: Plant Cell Volume: 25 Issue: 2 Pages: 558-571
  • DOI: 10.1105/tpc.112.105049
  • Peer Reviewed
• [Journal Article] S-nitrosylated a-l-acid glycoprotein kills drug-resistant bacteria and aids survival in sepsis (2013)
  • Author(s): Watanabe K, Ishima Y, Akaike T, Sawa T, Kuroda T, Ogawa W, Watanabe H, Suenaga A, Kai T, Otagiri M, and Maruyama T.
  • Journal Title: FASEB J Volume: 27 Issue: 1 Pages: 391-398
  • DOI: 10.1096/fj.12-217794
  • Peer Reviewed
• [Journal Article] Nitric oxide/soluble guanylyl cyclase signaling mediates depolarization-induced protection of rat mesencephalic dopaminergic neurons from MPP+ cytotoxicity (2013)
  • Author(s): Kurauchi Y, Hisatsune A, Isohama Y, Sawa T, Akaike T and Katsuki H.
  • Journal Title: Neurosci. Volume: 231 Pages: 206-215
  • DOI: 10.1016/j.neuroscience.2012.11.044
  • Peer Reviewed
• [Journal Article] レドックスシグナル制御と酸化ストレスバイオマーカー (2013)
  • Author(s): 赤池孝章、藤井重元
  • Journal Title: 精神科救急 Volume: 16 Pages: 69-72
• [Journal Article] 活性酸素シグナルの調節機構 ROS毒性説から脱却した新たな概念 (2013)
  • Author(s): 居原秀、井田智章、赤池孝章
  • Journal Title: Fragrance Journal Volume: 41 Pages: 75-80
• [Journal Article] 概論：活性酸素のシグナル伝達機能 その生理機能の再発見と酸化ストレス研究の新展開 (2013)
  • Author(s): 赤池孝章
  • Journal Title: 実験医学（増刊） Volume: 30 Pages: 22-29
• [Journal Article] 細胞の酸化ストレスを量る 親電子化合物8-nitro-cGMPの定量を例に 見つける、量る、可視化する！質量分析実験ガイド (2013)
  • Author(s): 澤 智裕、居原 秀、赤池孝章
  • Journal Title: 実験医学別冊 Volume: - Pages: 151-158
• [Journal Article] NOシグナリング研究の最前線 (2013)
  • Author(s): 澤 智裕、赤池孝章
  • Journal Title: Heart View Volume: 17 Pages: 88-92
• [Journal Article] 活性酸素とガス状分子のシグナルネットワーク (2013)
  • Author(s): 澤 智裕、赤池孝章
  • Journal Title: 医学のあゆみ Volume: 247 Pages: 776-780
• [Journal Article] はじめに –活性酸素と分子状酸素のバイオセンサーと生体応答- (2013)
  • Author(s): 赤池孝章、末松誠
  • Journal Title: 医学のあゆみ Volume: 247 Pages: 727-727
• [Journal Article] Nitrated cyclic GMP modulates guard cell signaling in Arabidopsis (2013)
  • Author(s): Joudoi T, Shichiri Y, Kamizono N, Akaike T, Sawa T, Yoshitake J, Yamada N, and Iwai S
  • Journal Title: Plant Cell Volume: 25 Pages: 558-71
  • Peer Reviewed
• [Journal Article] Redox signaling by 8-nitro-cyclic guanosine monophosphate: nitric oxide-and reactive oxygen species-derived electrophilic messenger (2013)
  • Author(s): Fujii S, and Akaike T
  • Journal Title: Antioxid Redox Signal Volume: (in press)
  • Peer Reviewed
• [Journal Article] Regulation of redox signalling by an electrophilic cyclic nucleotide (2013)
  • Author(s): Akaike T, Nishida M, and Fujii S
  • Journal Title: J Biochem Volume: 153 Pages: 131-8
  • NAID: 40019566342
  • Peer Reviewed
• [Journal Article] Nitric oxide/soluble guanylyl cyclase signaling mediates depolarization-induced protection of rat mesencephalic dopaminergic neurons from MPP+ cytotoxicity (2013)
  • Author(s): Kurauchi Y, Hisatsune A, Isohama Y, Sawa T, Akaike T, and Katsuki H
  • Journal Title: Neurosci Volume: (in press)
  • Peer Reviewed
• [Journal Article] S-Guanylation proteomics for redox-based mitochondrial signaling (2013)
  • Author(s): Rahaman MM, Sawa T, Ahtesham AK, Khan S, Inoue H, Irie A, Fujii S, and Akaike T
  • Journal Title: Antioxid Redox Signal Volume: (in press)
  • Peer Reviewed
• [Journal Article] Redox signaling by 8-nitro-cyclic guanosine monophosphate: nitric oxide- and reactive oxygen species-derived electrophilic messenger (2013)
  • Author(s): Fujii, S.
  • Journal Title: Antioxid. Redox Signal. Volume: 印刷中
  • Peer Reviewed
• [Journal Article] S-Guanylation proteomics for redox-based mitochondrial signaling (2013)
  • Author(s): Rahaman, Md. M.
  • Journal Title: Antioxid. Redox Signal. Volume: 印刷中
  • Peer Reviewed
• [Journal Article] NOシグナリング研究の最前線 (2013)
  • Author(s): 澤 智裕
  • Journal Title: Heart View Volume: 印刷中
• [Journal Article] Hydrogen sulfide anion regulates redox signaling via electrophile sulfhydration (2012)
  • Author(s): Nishida M, Sawa T, Kitajima N, Ono K, Inoue H, Ihara H, Motohashi H, Yamamoto M, Suematsu M, Kurose H, van der Vliet A, Freeman BA, Shibata T, Uchida K, Kumagai Y, and Akaike T
  • Journal Title: Nature Chem Biol Volume: 8 Pages: 714-24
  • Peer Reviewed
• [Journal Article] Keapl degradation by autophagy for the maintenance of redox homeostasis (2012)
  • Author(s): Taguchi K, Fujikawa N, Komatsu M, Ishii T, Unno M, Akaike T, Motohashi H, and Yamamoto M
  • Journal Title: Proc Natl Acad Sci USA Volume: 109 Pages: 13561-6
  • Peer Reviewed
• [Journal Article] Highly activatable and environment-insensitive optical highlighters for selective spatiotemporal imaging of target proteins (2012)
  • Author(s): Kobayashi T, Komatsu T, Kamiya M Campos C, Gonzalez-Gaitan M, Terai T, Hanaoka K, Nagano T, Urano Y
  • Journal Title: J Am Chem Soc Volume: 134 Pages: 11153-60
  • Peer Reviewed
• [Journal Article] RRedox signal-mediated sensitization of transient receptor potential melastatin 2 (TRPM2) to temperature affects macrophage functions (2012)
  • Author(s): Kashio M, Sokabe T, Shintaku K, Uematsu T, Fukuta N, Kobayashi N, Mori Y, Tominaga M
  • Journal Title: Proc Natl Acad Sci USA Volume: 109 Pages: 6745-50
  • Peer Reviewed
• [Journal Article] Interleukin-11 links oxidative stress and compensatory proliferation (2012)
  • Author(s): Nishina T, Komazawa-Sakon S, Yanaka S, Piao X, Zheng DM, Piao JH, Kojima Y, Yamashina S, Sano E, Putoczki T, Doi T, Ueno T, Ezaki J, Ushio H, Ernst M, Tsumoto K, Okumura K, and Nakano H
  • Journal Title: Sci Signal Volume: 5
  • Peer Reviewed
• [Journal Article] c-FLIP maintains tissue homeostasis by preventing apoptosis and programmed necrosis (2012)
  • Author(s): Piao, X, Komazawa-Sakon S, Nishina T, Koike M, Piao JH, Ehlken H, Kunihara H, Hara M, Van Rooijen N, Schutz G, Ohmuraya M, Uchiyama Y, Yagita H, Okumura K, He YW, and Nakano H
  • Journal Title: Sci Signal Volume: 5
  • Peer Reviewed
• [Journal Article] Hydrogen sulfide anion regulates redox signaling via electrophile sulfhydration. (2012)
  • Author(s): Nishida M., et al
  • Journal Title: Nature Chen. Biol. Volume: 8 Issue: 8 Pages: 714-724
  • DOI: 10.1038/nchembio.1018
  • Peer Reviewed
• [Journal Article] Keap1 degradation by autophagy for the maintenance of redox homeostasis (2012)
  • Author(s): Taguchi K, Fujikawa N, Komatsu M, Ishii T, Unno M, Akaike T, Motohashi H, and Yamamoto M
  • Journal Title: Proc. Natl. Acad. Sci. USA Volume: 109 Issue: 34 Pages: 13561-13566
  • DOI: 10.1073/pnas.1121572109
  • Peer Reviewed
• [Journal Article] S-Guanylation of human serum albumin is a unique posttranslational modification and results in a novel class of antibacterial agents (2012)
  • Author(s): Ishima Y, Hoshino H, Shinagawa T, Watanabe K, Akaike T, Sawa T, Kragh-Hansen U, Kai T, Watanabe H, Maruyama T, and Otagiri M
  • Journal Title: J. Pharm. Sci Volume: 101 Issue: 9 Pages: 3222-3229
  • DOI: 10.1002/jps.23143
  • Peer Reviewed
• [Journal Article] Anks4b, a novel target of HNF4α interacts with GRP78 and regulates endoplasmic reticulum stress-induced apoptosis in pancreatic β-cells (2012)
  • Author(s): Sato Y, Hatta M, Karim MF, Sawa T, Wei F-Y, Sato S, Magnuson MA, Gonzalez FJ, Tomizawa K, Akaike T, Yoshizawa T, and Yamagata K
  • Journal Title: J. Biol. Chem Volume: 287 Issue: 27 Pages: 23236-23245
  • DOI: 10.1074/jbc.m112.368779
  • Peer Reviewed
• [Journal Article] HGF-mediated inhibition of oxidative stress by 8-nitro-cGMP in high glucose-treated rat mesangial cells (2012)
  • Author(s): Guoguo S, Akaike T, Tao J, Qi C, Nong Z, and Hui L
  • Journal Title: Free Radic. Res Volume: 46 Issue: 10 Pages: 1238-1248
  • DOI: 10.3109/10715762.2012.701292
  • Peer Reviewed
• [Journal Article] Nitric oxide promotes recycling of 8-nitro-cGMP, a cytoprotectivemediator, into intact cGMP in cells (2012)
  • Author(s): Yohei Saito, Tomohiro Sawa, Jun Yoshitake, Chiaki Ito, Shigemoto Fujii, Takaaki Akaike and Hirokazu Arimoto
  • Journal Title: Moi BioSyst Volume: 8 Issue: 11 Pages: 2909-2915
  • DOI: 10.1039/c2mb25189b
  • Peer Reviewed
• [Journal Article] 硫化水素と炎症 (2012)
  • Author(s): 藤井重元
  • Journal Title: 感染・炎症・免疫 Volume: 42 Pages: 235-237
• [Journal Article] 活性酸素のシグナル伝達系と分子標的 (2012)
  • Author(s): 澤 智裕
  • Journal Title: 日本臨床（増刊号） Volume: 70 Pages: 273-276
• [Journal Article] 概論：活性酸素によるレドックス恒常性制御の新たなパラダイム転換に迫る (2012)
  • Author(s): 赤池孝章
  • Journal Title: 実験医学（増刊） Volume: 30 Pages: 2690-2696
• [Journal Article] ROS・親電子リガンドとガス状分子のシグナルネットワーク (2012)
  • Author(s): 澤 智裕
  • Journal Title: 実験医学（増刊） Volume: 30 Pages: 2740-2745
• [Journal Article] 新・活性酸素中毒 (2012)
  • Author(s): 赤池孝章
  • Journal Title: ファルマシア Volume: 48 Pages: 1-1
  • Peer Reviewed
• [Journal Article] 基礎の基礎 (2012)
  • Author(s): 赤池孝章
  • Journal Title: 細胞工学 Volume: 31 Pages: 134-137
  • Peer Reviewed
• [Journal Article] ニトロ化環状ヌクレオチドによるタンパク質S-グアニル化を介する酸化ストレス適応応答の分子機序 (2012)
  • Author(s): 藤井重元、赤池孝章
  • Journal Title: 生化学 Volume: 84 Pages: 124-128
  • NAID: 10030346449
  • Peer Reviewed
• [Journal Article] TRPA1 underlies a sensing mechanism for O_2 (2011)
  • Author(s): Takahashi N, Kuwaki T, Kiyonaka S, Numata T, Kozai D, Mizuno Y, Yamamoto S, Naito S, Knevels E, Carmeliet P, Oga T, Kaneko S, Suga S, Nokami T, Yoshida J, and Mori Y
  • Journal Title: Nature Chem Biol Volume: 7 Pages: 701-11
  • Peer Reviewed
• [Journal Article] Thioredoxin mediates oxidation-dependent phosphorylation of CRMP2 and growth cone collapse (2011)
  • Author(s): Morinaka A, Yamada M, Itofusa R, Funato Y, Yoshimura Y, Nakamura F, Yoshimura T, Kaibuchi K, Goshima Y, Hoshino M, Kamiguchi H, and Miki H
  • Journal Title: Sci Signal Volume: 4
  • Peer Reviewed
• [Journal Article] Structural basis for interaction between the conserved cell polarity proteins Inscuteable and Leu-Gly-Asn repeat-enriched protein (LGN) (2011)
  • Author(s): Yuzawa S, Kamakura S, Iwakiri Y, Hayase J, Sumimoto H
  • Journal Title: Proc Natl Acad Sci USA Volume: 108 Pages: 19210-15
  • Peer Reviewed
• [Journal Article] Polarity proteins Bem1 and Cdc24 are components of the filamentous fungal NADPH oxidase complex (2011)
  • Author(s): Takemoto D, Kamakura S, Saikia S, Becker Y, Wrenn R, Tanaka A, Sumimoto H, and Scott B
  • Journal Title: Proc Natl Acad Sci USA Volume: 108 Pages: 2861-6
  • Peer Reviewed
• [Journal Article] Heterologous down-regulation of angiotensin type 1 receptors by purinergic P2Y2 receptor stimulation through S-nitrosylation of NF-kappaB (2011)
  • Author(s): Nishida M, Ogushi M, Suda R, Toyotaka M, Saiki S, Kitajima N, Nakaya M, Kim KM, Ide T, Sato Y, Inoue K, and Kurose H
  • Journal Title: Proc Natl Acad Sci USA Volume: 108 Pages: 6662-7
  • Peer Reviewed
• [Journal Article] On-off system for PI3-kinase-Akt signaling through S-nitrosylation of phosphatase with sequence homology to tensin (PTEN) (2011)
  • Author(s): Numajiri N, Takasawa K, Nishiya T, Tanaka H, Ohno K, Hayakawa W, Asada M, Matsuda H, Azumi K, Kamata H, Nakamura T, Hara H, Minami M, Lipton SA, and Uehara T
  • Journal Title: Proc Natl Acad Sci USA Volume: 108 Pages: 10349-54
  • Peer Reviewed
• [Journal Article] Phosphorylation of the nicotiana benthamiana WRKY8 transcription factor by MAPK functions in the defense response (2011)
  • Author(s): Ishihama N, Yamada R, Yoshioka M, Katou S, Yoshioka H
  • Journal Title: Plant Cell Volume: 23 Pages: 1153-70
  • Peer Reviewed
• [Journal Article] Midbrain dopaminergic neurons utilize nitric oxide/cyclic GMP signaling to recruit ERK that links retinoic acid receptor stimulation to up-regulation of BDNF (2011)
  • Author(s): Kurauchi Y., et al
  • Journal Title: J Neurochem Volume: 116 Issue: 3 Pages: 323-333
  • DOI: 10.1111/j.1471-4159.2010.06916.x
  • Peer Reviewed
• [Journal Article] Vascular responses to 8-nitro-cyclic GMP in non-diabetic and diabetic mice (2011)
  • Author(s): Tokutomi Y., et al
  • Journal Title: Br J Pharmabol Volume: 162 Issue: 8 Pages: 1884-1893
  • DOI: 10.1111/j.1476-5381.2011.01201.x
  • Peer Reviewed
• [Journal Article] Protein cysteine S-guanylation and electrophilic signal transduction by endogenous nitro-nucleotides (2011)
  • Author(s): Ahmed KA., et al
  • Journal Title: Amino Acids Volume: 41 Issue: 1 Pages: 123-130
  • DOI: 10.1007/s00726-010-0535-1
  • Peer Reviewed
• [Journal Article] Antioxidant Effect of a Nitrated Cyclic Nucleotide Functioning as an Endogenous Electrophile (2011)
  • Author(s): Sawa T., et al
  • Journal Title: Curr Top Med Chem Volume: 11 Pages: 1854-1860
  • Peer Reviewed
• [Journal Article] Detoxification of methylmercury by hydrogen sulfide-producing enzyme in Mammalian cells (2011)
  • Author(s): Yoshida E, Toyama T (equalcontributor), Shinkai Y, Sawa T, Akaike T, Kumagai Y
  • Journal Title: Chemical Research in Toxicology Volume: 24 Issue: 10 Pages: 1633-1635
  • DOI: 10.1021/tx200394g
  • Peer Reviewed
• [Journal Article] Cellular uptake mechanisms and responses to NO transferred from mono- and poly-S-nitrosated human serum albumin (2011)
  • Author(s): Yu Ishima., et al
  • Journal Title: Free Radical Research Volume: 45 Issue: 10 Pages: 1196-1206
  • DOI: 10.3109/10715762.2011.606814
  • Peer Reviewed
• [Journal Article] 喫煙と酸化ストレス:Oxidative stress induced by cigarette smoking (2011)
  • Author(s): 岡本竜哉, 他
  • Journal Title: 最新精神医学 Volume: 16 Pages: 431-439
• [Journal Article] 活性酸素・一酸化窒素によるニトロ化シグナルと抗炎症作用 (2011)
  • Author(s): 澤智裕, 他
  • Journal Title: 感染・炎症・免疫 Volume: 41 Pages: 12-19
• [Journal Article] Heterologous down-regulation of angiotensin type 1 receptors by purinergic P2Y2 receptor stimulation though S-nitrosylation of NF-kappaB (2011)
  • Author(s): Nishida, M., Ogushi, M., Suda, R., Toyotaka, M., Saiki, S., Kitajima, N., Nakaya, M., Kim, K.M., Ide, T., Sato, Y., Inoue, K., Kurose, H.
  • Journal Title: Proc.Natl.Acad.Sci.USA 108 Pages: 6662-6667
  • Peer Reviewed
• [Journal Article] Methodological proof of immunochemistry for specific identification of 8-nitroguanosine 3',5'-cyclic monophosphate formed in glia cells (2011)
  • Author(s): Ihara H., et al
  • Journal Title: Nitric Oxide Volume: (in press)
  • Peer Reviewed
• [Journal Article] Vascular responses to 8-nitro-cyclic GMP in nondiabetic and diabetic mice (2011)
  • Author(s): Tokutomi Y., et al
  • Journal Title: Br J Pharmacol Volume: (in press)
  • Peer Reviewed
• [Journal Article] The selective autophagy substrate p62 activates the stress responsive transcription factor Nrf2 through inactivation of Keapl (2010)
  • Author(s): Komatsu M, Kurokawa H, Waguri S, Taguchi K, Kobayashi A, Ichimura Y, Sou YS, Ueno I, Sakamoto A, Tong KI, Kim M, Nishito Y, Iemura S, Natsume T, Ueno T, Kominami E, Motohashi H, Tanaka K, and Yamamoto M
  • Journal Title: Nature Cell Biol Volume: 12 Pages: 213-23
  • Peer Reviewed
• [Journal Article] Different modes of ubiquitination of the adaptor TRAF3 selectively activate the expression of type I interferons and proinflammatory cytokines (2010)
  • Author(s): Tseng PH, Matsuzawa A, Zhang W, Mino T, Vignali DA, and Karin M
  • Journal Title: Nature Immunol Volume: 11 Pages: 70-5
  • Peer Reviewed
• [Journal Article] Nuclear IKKbeta is an adaptor protein for IkappaBalpha ubiquitination and degradation in UV-induced NF-kappaB activation (2010)
  • Author(s): Tsuchiya Y, Asano T, Nakayama K, Kato T, Jr., Karin M, and Kamata H
  • Journal Title: Mol Cell Volume: 39 Pages: 570-82
  • Peer Reviewed
• [Journal Article] Nucleotides function as endogenous chemical sensors for oxidative stress signaling (2010)
  • Author(s): Ihara H., et al
  • Journal Title: Journal of Clinical Biochemistry and Nutrition Volume: 48 Issue: 1 Pages: 33-39
  • DOI: 10.3164/jcbn.11-003FR
  • NAID: 130004879228
  • ISSN: 0912-0009, 1880-5086
  • Peer Reviewed
• [Journal Article] Nuclear IKKbeta is an adaptor protein for IkappaBalpha ubiquitination and degradation in UV-induced NF-kappaB activation (2010)
  • Author(s): Tsuchiya, Y., Asano, T., Nakayama, K., Kato, T.Jr., Karin, M., Kamata, H.
  • Journal Title: Mol.Cell 39 Pages: 570-582
  • Peer Reviewed
• [Journal Article] The critical role of nitric oxide signaling, via protein S-guanylation and nitrated cyclic GMP, in the antioxidant adaptive response (2010)
  • Author(s): Fujii, S., Sawa, T., Ihara, H., Tong, K., Ida, T., Okamoto, T., Ahtesham, A.K., Ishima, Y., Motohashi, H., Yamamoto, M., Akaike, T
  • Journal Title: J.Biol.Chem 285 Pages: 23970-23984
  • Peer Reviewed
• [Journal Article] A new paradigm for antimicrobial host defense mediated by a nitrated cyclic nucleotide (2010)
  • Author(s): Okamoto T., et al
  • Journal Title: J Clin Biochem Nutr Volume: 46 Pages: 14-19
  • Peer Reviewed
• [Journal Article] The critical role of nitric oxide signaling, via protein S-guanylation and nitrated cyclic GMP, in the antioxidant adaptive response (2010)
  • Author(s): Fujii S., et al
  • Journal Title: J Biol Chem Volume: 285 Pages: 23970-23984
  • Peer Reviewed
• [Journal Article] Protein cysteine S-guanylation and electrophilic signal transduction by endogenous nitro-nucleotides (2010)
  • Author(s): Ahmed K.A., et al
  • Journal Title: Amino Acids Volume: (in press)
  • Peer Reviewed
• [Journal Article] Regulation of redox signaling involving chemical conjugation of protein thiols by nitric oxide and electrophiles (2010)
  • Author(s): Sawa T., et al
  • Journal Title: Bioconjugate Chem Volume: 21 Pages: 1121-1129
  • Peer Reviewed
• [Journal Article] Cell signaling mediated by nitrated cyclic guanine nucleotide (2010)
  • Author(s): Akaike T., et al
  • Journal Title: Nitric Oxide Volume: 23 Pages: 166-174
  • NAID: 120002772115
  • Peer Reviewed
• [Journal Article] One-step preparation of S-nitrosated human serum albumin with high biological activities (2010)
  • Author(s): Ishima Y., et al
  • Journal Title: Nitric Oxide Volume: 23 Pages: 121-127
  • Peer Reviewed
• [Journal Article] Antioxidant effect of a nitrated cyclic nucleotide functioning as an endogenous electrophile (2010)
  • Author(s): Sawa T., et al
  • Journal Title: Current Topics Med Chem Volume: (in press)
  • Peer Reviewed
• [Journal Article] 呼吸器疾患における酸化ストレスと制御シグナルの分子基盤: Molecularmechanisms of nitric oxide- and reactive oxygen species-mediated signalings in the respiratory diseases (2010)
  • Author(s): 岡本竜哉, 他
  • Journal Title: 呼吸 Volume: 29 Pages: 859-866
• [Journal Article] 8-Nitro-cGMPの発見と生理機能の解明 (2010)
  • Author(s): 藤井重元, 他
  • Journal Title: 化学と生物 Volume: 48 Pages: 22-27
• [Journal Article] 毒性説から脱した活性酸素研究-シグナル分子としての活躍- (2010)
  • Author(s): 澤智裕, 他
  • Journal Title: 現代化学 Volume: 469 Pages: 34-38
• [Journal Article] The critical role of nitric oxide signaling, via protein S-guanylation and nitrated cyclic GMP, in the antioxidant adaptive response (2010)
  • Author(s): Fujii S., et al
  • Journal Title: J Biol Chem (in press)
  • Peer Reviewed
• [Journal Article] Cellular signaling mediated by nitrated cyclic nucleotides (2010)
  • Author(s): Akaike T., et al
  • Journal Title: Nitric Oxide (in press)
  • Peer Reviewed
• [Journal Article] Regulation of redox signaling involving chemical conjugation of protein thiols by nitric oxide and electrophiles (2010)
  • Author(s): Sawa T., et al
  • Journal Title: Bioconjug Chem (in press)
  • Peer Reviewed
• [Journal Article] Protein cysteine S-guanylation and electrophilic signal transduction by endogenous nitronucleotides (2010)
  • Author(s): Ahmed KA., et al
  • Journal Title: Amino Acids (in press)
  • Peer Reviewed
• [Journal Article] Hydrogen peroxide as an endothelium-delived hyperpolarizing factor (2010)
  • Author(s): Shimokawa H
  • Journal Title: Pflugers Arch (in press)
  • Peer Reviewed
• [Journal Article] Development and application of a near-infrared fluorescence probe for oxidative stress based on differential reactivity of linked cyanine dyes (2010)
  • Author(s): Oushiki D, Urano Y., et al
  • Journal Title: J Am Chem Soc 132 Pages: 2795-2801
  • Peer Reviewed
• [Journal Article] Discovery of a novel series of semisynthetic vancomycin derivatives effective against vancomycin-resistant bacteria (2010)
  • Author(s): Nakama Y, Arimoto H., et al
  • Journal Title: J Med Chem 53 Pages: 2528-2533
  • Peer Reviewed
• [Journal Article] 毒性説から脱した活性酸素研究-シグナル分子としての活躍- (2010)
  • Author(s): 澤智裕, 他
  • Journal Title: 現代化学 469 Pages: 34-38
• [Journal Article] 8-Nitro-cGMPの発見と生理機能の解明- (2010)
  • Author(s): 藤井重元, 他
  • Journal Title: 化学と生物 48 Pages: 22-27
• [Journal Article] Assembly pathway of the Mammalian proteasome base subcomplex is mediated by multiple specific chaperones (2009)
  • Author(s): Kaneko T, Hamazaki J, Iemura S, Sasaki K, Furuyama K, Natsume T, Tanaka K, and Murata S
  • Journal Title: Cell Volume: 137 Pages: 914-25
  • Peer Reviewed
• [Journal Article] Ubiquitin-like sequence in ASK1 plays critical roles in the recognition and stabilization by USP9X and oxidative stress-induced cell death (2009)
  • Author(s): Nagai H, Noguchi T, Homma K, Katagiri K, Takeda K, Matsuzawa A, and Ichijo H
  • Journal Title: Mol Cell Volume: 36 Pages: 805-18
  • Peer Reviewed
• [Journal Article] Selective molecular imaging of viable cancer cells with pH-activatable fluorescence probes (2009)
  • Author(s): Urano Y, Asanuma D, Hama Y, Koyama Y, Barrett T, Kamiya M, Nagano T, Watanabe T, Hasegawa A, Choyke PL, and Kobayashi H
  • Journal Title: Nature Med Volume: 15 Pages: 104-9
  • Peer Reviewed
• [Journal Article] NF-kB2 (p100) limits TNF-a-induced osteoclastogenesis (2009)
  • Author(s): Tanaka S, and Nakano H
  • Journal Title: J Clin Invest Volume: 119 Pages: 2879-81
  • Peer Reviewed
• [Journal Article] Selective molecular imaging of viable cancer cells with pH-activable fluorescence probes (2009)
  • Author(s): Urano, Y., Asanuma, D., Hama, Y., Koyama, Y., Barrett, T., Kamiya, M., Nagano, T., Watanabe, T., Hasegawa, A., Choyke, P.L., Kobayashi, H.
  • Journal Title: Nat.Med 15 Pages: 104-109
  • Peer Reviewed
• [Journal Article] Cytoprotective function of heme oxygenase-1 induced by a nitrated cyclic nucleotide formed during murine salmonellosis (2009)
  • Author(s): Zaki MH., et al
  • Journal Title: J Immnol 182 Pages: 3746-3756
  • Peer Reviewed
• [Journal Article] Stereochemical configuration of 4-hydroxy-2-nonenal-cysteine adducts and their stereoselective formation in a redox-regulated protein (2009)
  • Author(s): Wakita C, Uchida K., et al
  • Journal Title: J Biol Chem 284 Pages: 28810-28822
  • Peer Reviewed
• [Journal Article] Thioredoxin-interacting protein (Txnip) is a feedback regulator of S-nitrosylation (2009)
  • Author(s): Forrester MT. Matsumoto A., et al
  • Journal Title: J Biol Chem 284 Pages: 36160-36166
  • Peer Reviewed
• [Journal Article] 活性酸素のシグナル伝達機能-その生理機能の再発見と酸化ストレス研究の新展開 (2009)
  • Author(s): 赤池孝章, 他
  • Journal Title: 実験医学増刊:病態解明に迫る活性酸素シグナルと酸化ストレス 27 Pages: 2320-2329
• [Journal Article] チオール基の修飾による活性酸素のセンサー機能制御 (2009)
  • Author(s): 澤智裕, 他
  • Journal Title: 実験医学増刊:病態解明に迫る活性酸素シグナルと酸化ストレス 27 Pages: 2341-2347
• [Journal Article] NOによる細胞内感染防御の新しい展開-New paradigm of host defense against intracellular pathogens by nitric oxide (2009)
  • Author(s): 赤池孝章, 他
  • Journal Title: 日本ハンセン病学会雑誌 78 Pages: 41-47
• [Journal Article] 活性酸素・NOによる感染防御シグナルの新展開-Antimicrobial signaling mediated by reactive oxygen species and NO (2009)
  • Author(s): 岡本竜哉, 他
  • Journal Title: 細胞 41 Pages: 51-55
• [Journal Article] Cytoprotective function of heme oxygenase-1 induced by a nitrated cyclic nucleotide formed during murine salmonellosis (2009)
  • Author(s): Zaki MH, et.al.
  • Journal Title: J Immunol 182 Pages: 3746-3756
  • Peer Reviewed
• [Journal Article] Identification of Advanced Reaction Products Originating from the Initial 4-Oxo-2-nonenal-cysteine Michael Adducts (2009)
  • Author(s): Shimozu Y, Uchida K, et.al.
  • Journal Title: Chem Res Toxicol (in press)
  • Peer Reviewed
• [Journal Article] S-nitrosylated human serum albumin-mediated cytoprotective activity is enhanced by fatty acid binding (2008)
  • Author(s): Ishima Y, et.al.
  • Journal Title: J Biol Chem 283 Pages: 34966-34975
  • Peer Reviewed
• [Journal Article] 8-Nitroguanosines as chemical probes of the protein S-guanylation (2008)
  • Author(s): Saito Y, et.al.
  • Journal Title: Chem Commun 45 Pages: 5984-5986
  • Peer Reviewed
• [Journal Article] Nitric oxide regulation of MMP-9 activation and its relationship to modifications of the cysteine switch (2008)
  • Author(s): McCarthy SM, et.al.
  • Journal Title: Biochemistry 47 Pages: 5832-5840
  • Peer Reviewed
• [Journal Article] Suppression of NO production and 8-nitroguanosine formation by phenol-containing endocrine-disrupting chemicals in LPS-stimulated macrophages : Involvement of estrogen receptor-dependent or-independent pathways (2008)
  • Author(s): Yoshitake J, et.al.
  • Journal Title: Nitric Oxide 18 Pages: 223-228
  • Peer Reviewed
• [Journal Article] Angiopoietin-related growth factor enhances blood flow via activation of the ERK1/2-eN0S-NO-pathway in a mouse hind-limb ischemia model (2008)
  • Author(s): Urano T, et.al.
  • Journal Title: Arterioscler Thromb Vasc Biol 28 Pages: 827-834
  • Peer Reviewed
• [Journal Article] Nitric oxide produced in Peyer' s patches exhibits antiapoptotic activity contributing to an antimicrobial effect in murine salmonellosis (2008)
  • Author(s): Alarn MS, et.al.
  • Journal Title: Microbiol Immunol 52 Pages: 197-208
  • Peer Reviewed
• [Journal Article] Identification of the Major Antigenic Protein of Helicobacter cinaedi and the Immunogenicity During Infections in Humans (2008)
  • Author(s): Iwashita H, et.al.
  • Journal Title: Clin Vaccine Immunol 15 Pages: 513-521
  • Peer Reviewed
• [Journal Article] Mutagenicity of 8-nitroguanosine, a product of nitrative nucleoside modification by reactive nitrogen oxides, in mammalian cells (2008)
  • Author(s): Kaneko K, et.al.
  • Journal Title: Cancer Lett 262 Pages: 239-247
  • Peer Reviewed
• [Journal Article] 活性酸素を消去する物質8-ニトロcGMP (2008)
  • Author(s): 澤智裕、赤池孝章
  • Journal Title: 検査と技術 36 Pages: 678-679
  • Peer Reviewed
• [Journal Article] 感染病態におけるNO・活性酸素のシグナル伝達機能 : 酸化ストレスとその適応応答の分子メカニズム (2008)
  • Author(s): 岡本竜哉、他
  • Journal Title: Allergy From the Nose to the Lung 6 Pages: 12-17
  • Peer Reviewed
• [Journal Article] Structure, regulation and evolution of Nox-family NADPH oxidases that produce reactive oxygen species (2008)
  • Author(s): Sumimoto H
  • Journal Title: FEBS J 275 Pages: 3249-3277
  • Peer Reviewed
• [Journal Article] Crucial role of nitric oxide synthases system in endothelium-dependent hyperpolarization in mice (2008)
  • Author(s): Takaki A, Shimokawa H, et.al.
  • Journal Title: J Exp Med 205 Pages: 2053-2063
  • Peer Reviewed
• [Journal Article] Branched N-glycans regulate the biological functions of integrins and cadherins (2008)
  • Author(s): Zhao Y, Matsumoto A, et.al.
  • Journal Title: FEBS J 275 Pages: 1939-1948
  • Peer Reviewed
• [Journal Article] Selective molecular imaging of viable cancer cells with pH-activatable fluorescence probes (2008)
  • Author(s): Urano Y, et.al.
  • Journal Title: Nature Med 15 Pages: 104-109
  • Peer Reviewed
• [Journal Article] The conformational features of palytoxin in aqueous solution (2008)
  • Author(s): Inuzuka T, Arimoto H, et.al.
  • Journal Title: Tetrahedron 64 Pages: 7718-7723
  • Peer Reviewed
• [Journal Article] On-off system for PI3-kinase-Akt signaling through S-nitrosylation of PTEN
  • Author(s): Numajiri, N, Takasawa, K, Nishiya, T, Tanaka, H, Ohno, K., Hayakawa, W., Asada, M., Matsuda, H., Azumi, K., Kamata, H., Nakamura, T., Hara, H., Minami, M., Lipton, S.A., Uehara, T
  • Journal Title: Proc.Natl.Acad.Sci.USA in press
  • Peer Reviewed
• [Presentation] 酸化ストレスとオートファジー (2014)
  • Author(s): 赤池孝章
  • Organizer: 大阪大学蛋白質研究所セミナー
  • Place of Presentation: 大阪大学蛋白質研究所 （大阪府吹田市）
  • Invited
• [Presentation] Regulation of 8-nitro-cGMP electrophilic signal transduction (2014)
  • Author(s): Akaike T.
  • Organizer: The Environmental Response IV
  • Place of Presentation: 東北大学片平さくらホール （宮城県仙台市）
  • Invited
• [Presentation] 酸化ストレス応答とポリチオールバイオロジー (2014)
  • Author(s): 赤池孝章
  • Organizer: 日本農芸化学会2014年度大会
  • Place of Presentation: 明治大学生田キャンパス （神奈川県川崎市）
  • Invited
• [Presentation] 活性酸素による多階層シグナル伝達機構とレドックス恒常性制御 (2013)
  • Author(s): 赤池孝章
  • Organizer: 日本薬理学会第133年会
  • Place of Presentation: パシフィコ横浜（横浜市）
  • Year and Date: 2013-03-27
  • Invited
• [Presentation] 硫化水素によるレドックスシグナル制御 (2013)
  • Author(s): 赤池孝章
  • Organizer: 第12回分子予防環境医学研究会大会
  • Place of Presentation: つくばサイエンス・インフォメーションセンター（筑波）
  • Year and Date: 2013-02-01
  • Invited
• [Presentation] 活性イオウ分子による活性酸素シグナル制御 (2013)
  • Author(s): 赤池孝章
  • Organizer: 第22回日本Cell Death 学会学術集会
  • Place of Presentation: 京都大学医学部芝蘭会舘 （京都府京都市）
  • Invited
• [Presentation] 活性酸素シグナル制御とポリスルフィドミクス (2013)
  • Author(s): 赤池孝章
  • Organizer: 第86回日本生化学会
  • Place of Presentation: パシフィコ横浜 （神奈川県横浜市）
  • Invited
• [Presentation] Electrophilic modification of H-Ras underlies development of heart failure after myocardial infarction (2012)
  • Author(s): Nishida M
  • Organizer: Fourth International Symposium on Signaling Functions of Reactive Oxygen Species, Grants-in-Aid for Scientific Research on Innovative Areas, MEXT
  • Place of Presentation: Kyushu University, Fukuoka, Japan
  • Year and Date: 2012-12-17
• [Presentation] Mass spectrometric identification of unique polysulfides in biological systems (2012)
  • Author(s): Sawa T, Ida T, Akaike T
  • Organizer: Fourth International Symposium on Signaling Functions of Reactive Oxygen Species, Grants-in-Aid for Scientific Research on Innovative Areas, MEXT
  • Place of Presentation: Kyushu University, Fukuoka, Japan
  • Year and Date: 2012-12-17
• [Presentation] Keapl-Nrf2 system in metabolic reprogramming of cancer cells (2012)
  • Author(s): Motohashi H
  • Organizer: Fourth International Symposium on Signaling Functions of Reactive Oxygen Species, Grants-in-Aid for Scientific Research on Innovative Areas, MEXT
  • Place of Presentation: Kyushu University, Fukuoka, Japan
  • Year and Date: 2012-12-17
• [Presentation] The role of ribosome interacting protein GCN1L1 in oxidative stress-mediated Nrf2 activation (2012)
  • Author(s): Itoh K
  • Organizer: Functions of Reactive Oxygen Species, Grants-in-Aid for Scientific Research on Innovative Areas, MEXT
  • Place of Presentation: Kyushu University, Fukuoka, Japan
  • Year and Date: 2012-12-17
• [Presentation] Electrophilic ligands as a trigger of pro-inflammatory response (2012)
  • Author(s): Uchida K
  • Organizer: Fourth International Symposium on Signaling Functions of Reactive Oxygen Species, Grants-in-Aid for Scientific Research on Innovative Areas, MEXT
  • Place of Presentation: Kyushu University, Fukuoka, Japan
  • Year and Date: 2012-12-17
• [Presentation] Redox physiology of TRP channels (2012)
  • Author(s): Mori Y
  • Organizer: Fourth International Symposium on Signaling Functions of Reactive Oxygen Species, Grants-in-Aid for Scientific Research on Innovative Areas, MEXT
  • Place of Presentation: Kyushu University, Fukuoka, Japan
  • Year and Date: 2012-12-17
• [Presentation] Oxidative stress maintains tissue homeostasis by inducing compensatory proliferation (2012)
  • Author(s): Nakano H
  • Organizer: Fourth International Symposium on Signaling Functions of Reactive Oxygen Species, Grants-in-Aid for Scientific Research on Innovative Areas, MEXT
  • Place of Presentation: Kyushu University, Fukuoka, Japan
  • Year and Date: 2012-12-17
• [Presentation] Persulfide regulation of redox signaling involving unique polysulfur biology (2012)
  • Author(s): Akaike, T
  • Organizer: 第85回日本生化学会大会
  • Place of Presentation: 福岡国際会議場（福岡）
  • Year and Date: 2012-12-14
  • Invited
• [Presentation] レドックスシグナル制御と酸化ストレスバイオマーカー (2012)
  • Author(s): 赤池孝章
  • Organizer: 第20回日本精神科救急学会学術総会
  • Place of Presentation: 奈良県新公会堂（奈良市）
  • Year and Date: 2012-10-27
  • Invited
• [Presentation] 感染防御における活性酸素シグナル制御と破綻 (2012)
  • Author(s): 赤池孝章
  • Organizer: 第65回日本細菌学会中国・四国支部総会
  • Place of Presentation: 徳島大学（徳島市）
  • Year and Date: 2012-10-20
  • Invited
• [Presentation] Hydrogen sulfide regulation for electrophile-mediated ROS signaling (2012)
  • Author(s): Akaike, T
  • Organizer: Second International Conference on H2S Biology and Medicine
  • Place of Presentation: Atlanta, USA
  • Year and Date: 2012-09-20
• [Presentation] 8-SH-cGMP endogenously formed from 8-nitro-cGMP as a second messenger of hydrogen sulfide (2012)
  • Author(s): Akaike, T.
  • Organizer: The 7th International Conference on the Biology, Chemistry and Therapeutic Applications of Nitric Oxide
  • Place of Presentation: Edinburgh, UK
  • Year and Date: 2012-07-22
• [Presentation] 硫化水素によるレドックスシグナル制御：新しいセカンドメッセンジャー8-SH-cGMPの発見 (2012)
  • Author(s): 赤池孝章
  • Organizer: 第12回日本NO学会学術集会
  • Place of Presentation: 神戸国際会議場（神戸市）
  • Year and Date: 2012-06-29
  • Invited
• [Presentation] Nitrated cyclic nucleotide mediates endogenous electrophilic signaling for Ras-dependent senescence and autophagy (2012)
  • Author(s): Akaike, T.
  • Organizer: The 33rd Naito Conference
  • Place of Presentation: ガトーキングダムサッポロ（札幌市）
  • Year and Date: 2012-06-26
  • Invited
• [Presentation] 生体の酸化還元状態・環境を感知するチャネル機構:TRP (2012)
  • Author(s): 森泰生
  • Organizer: 文部科学省新額術領域研究「活性酸素のシグナル伝達機能」特別公開シンポジウム
  • Place of Presentation: 沖縄かりゆしアーバンリゾート・ナハ、(沖縄)
  • Year and Date: 2012-06-18
• [Presentation] トップジャーナル七転び八起き (2012)
  • Author(s): 赤池孝章
  • Organizer: 第85回日本細菌学会総会
  • Place of Presentation: 長崎ブリックホール(長崎)(招待講演)
  • Year and Date: 2012-03-27
• [Presentation] Cellular signaling mediated by nitrated cyclic nucleotides and its regulation by hydrogen sulfide (2011)
  • Author(s): Takaaki Akaike
  • Organizer: The 23^<rd> Annual Meeting of the Korean Society for Molecular and Cellular Biology
  • Place of Presentation: COEX(ソウル韓国)(招待講演)
  • Year and Date: 2011-10-06
• [Presentation] ROS and electrophilic cellular signaling regulated by hydrogen sulfide (2011)
  • Author(s): 赤池孝章, 他
  • Organizer: 第84回日本生化学会大会
  • Place of Presentation: 国立京都国際会館(京都)(招待講演)
  • Year and Date: 2011-09-21
• [Presentation] Antimicrobial cell signaling mediated by nitrated cyclic nucleotide (2011)
  • Author(s): Takaaki Akaike
  • Organizer: 第84回日本細菌学会総会
  • Place of Presentation: 札幌コンベンションセンター(札幌)(招待講演)
  • Year and Date: 2011-09-06
• [Presentation] 内因性硫化水素イオンによるROS・親電子シグナル制御 (2011)
  • Author(s): 赤池孝章
  • Organizer: 第2回Molecular Cardiovascular Conference II
  • Place of Presentation: ホテルピアノ(北海道キロロ)(招待講演)
  • Year and Date: 2011-09-02
• [Presentation] 生体内ガス分子と活性酸素による多次元シグナルネットワーク (2011)
  • Author(s): 赤池孝章
  • Organizer: 第8回Home Oxygenase研究フォーラム
  • Place of Presentation: 京都府立医科大学・青蓮会館(京都)(招待講演)
  • Year and Date: 2011-08-26
• [Presentation] Protein S-guanylation and its unique regulation mechanisms involving cysteine metabolism (2011)
  • Author(s): Takaaki Akaike
  • Organizer: 12th International congress on amino acids, peptides and proteins
  • Place of Presentation: Beijing International Convention Center(北京)
  • Year and Date: 2011-08-01
• [Presentation] 親電子シグナルと硫化水素.九州大学生体防御医学研究所共同利用 (2011)
  • Author(s): 赤池孝章
  • Organizer: 九州大学生体防御医学研究所共同利用研究集会
  • Place of Presentation: 九州大学生体防御医学研究所会議室(福岡)(招待講演)
  • Year and Date: 2011-07-22
• [Presentation] 内因性硫化水素イオンによる親電子シグナル制御 (2011)
  • Author(s): 赤池孝章
  • Organizer: 64回日本酸化ストレス学会学術集会
  • Place of Presentation: ルスツリゾートホテル&コンベンション(北海道留寿都)(招待講演)
  • Year and Date: 2011-07-02
• [Presentation] Cellular signaling mediated by nitrated cyclic nucleotide and regulated by hydrogen sulfide. 5th International Conference on cGMP (2011)
  • Author(s): Takaaki Akaike
  • Organizer: 第5回cGMP国際会議
  • Place of Presentation: Lowengebaude, (Halle, Germany)(招待講演)
  • Year and Date: 2011-06-23
• [Presentation] 活性酸素シグナル伝達と加齢 (2011)
  • Author(s): 赤池孝章
  • Organizer: 第11回日本抗加齢医学会総会
  • Place of Presentation: 国立京都国際会館(京都)(招待講演)
  • Year and Date: 2011-05-27
• [Presentation] lectrophilic cellular signaling regulated by H2S-mediated sulfhydration (2011)
  • Author(s): Akaike T
  • Organizer: Third International Symposium on Signaling Functions of Reactive Oxygen Species, Grants-in-Aid for Scientific Research on Innovative Areas, MEXT
  • Place of Presentation: Showa Pharmaceutical University, Tokyo, Japan
  • Year and Date: 2011-05-14
• [Presentation] A novel modulatory 'on-off' system for PI 3-kinase-Akt signaling through S-nitrosylation (2011)
  • Author(s): Uehara T
  • Organizer: Third International Symposium on Signaling Functions of Reactive Oxygen Species, Grants-in-Aid for Scientific Research on Innovative Areas, MEXT
  • Place of Presentation: Showa Pharmaceutical University, Tokyo, Japan
  • Year and Date: 2011-05-14
• [Presentation] Regulatory crosstalk of redox homeostasis and anabolic metabolism by the Keap1-Nrf2 pathway (2011)
  • Author(s): Motohashi H
  • Organizer: Third International Symposium on Signaling Functions of Reactive Oxygen Species, Grants-in-Aid for Scientific Research on Innovative Areas, MEXT
  • Place of Presentation: Showa Pharmaceutical University, Tokyo, Japan
  • Year and Date: 2011-05-14
• [Presentation] Electrophilic cellular signaling regulated by H_2S-medaited sulfhydration (2011)
  • Author(s): Takaaki Akaike
  • Organizer: 第11回日本NO学会総会
  • Place of Presentation: 昭和薬科大学(東京都町田市)
  • Year and Date: 2011-05-13
• [Presentation] Cellular signaling by nitrated cyclic nucleotides and regulation of its biological effects (2011)
  • Author(s): Akaike, T
  • Organizer: Gordon Research Conference on Nitric Oxide
  • Place of Presentation: Ventura,CA,USA
  • Year and Date: 2011-02-17
• [Presentation] Cellular signaling by nitrated cyclic nucleotides and regulation of its biological effects (2011)
  • Author(s): Akaike T.
  • Organizer: Gordon Research Conferemce on Nitric Oxide : Understanding the Biology and Chemistry of Its Formation, Action, and Signaling
  • Place of Presentation: Four Points Sheraton/Holiday InnExpress (Ventura, CA, USA)
  • Year and Date: 2011-02-17
• [Presentation] Cell signaling mediated by nitrated cyclic guanine nucleotide (2011)
  • Author(s): Akaike, T
  • Organizer: International Symposium on Free Radical Research : Contribution to Medicine
  • Place of Presentation: Kyoto,Japan
  • Year and Date: 2011-01-21
• [Presentation] Cell signaling mediated by nitrated cyclic guanine nucleotide (2011)
  • Author(s): Akaike T.
  • Organizer: International Symposium on Free Radical Research : Contribution to Medicine
  • Place of Presentation: Hyatt Regency Kyoto(京都市)
  • Year and Date: 2011-01-21
• [Presentation] 核酸分子の化学修飾による活性酸素シグナルのケミカルセンシング (2010)
  • Author(s): 澤智裕, 他
  • Organizer: 第83回日本生化学会大会
  • Place of Presentation: ポートアイランド(神戸市)
  • Year and Date: 2010-12-07
• [Presentation] NOによる抗酸化応答の新展開 (2010)
  • Author(s): 澤智裕, 他
  • Organizer: 第27回臨床フリーラジカル会議
  • Place of Presentation: 京都・烟河(京都市)
  • Year and Date: 2010-12-04
• [Presentation] Glyceraldehyde 3-phosphate dehydrogenaseの基質依存的な酸化的不活性化 (2010)
  • Author(s): 小野勝彦, 他
  • Organizer: 第63回日本酸化ストレス学会学術集会
  • Place of Presentation: 神奈川県民ホール(横浜市)
  • Year and Date: 2010-06-24
• [Presentation] 細胞内における8-nitro-cGMP生成メカニズムの解析 (2010)
  • Author(s): 吉武淳, 他
  • Organizer: 第63回日本酸化ストレス学会学術集会
  • Place of Presentation: 神奈川県民ホール(横浜市)
  • Year and Date: 2010-06-24
• [Presentation] Critical roles of nitric oxide signaling via 8-nitro-cGMP-induced protein S-guanylation in antioxidant adaptive responses (2010)
  • Author(s): Fujii S, et al
  • Organizer: The 26th Kumamoto Medical Bioscience Symposium
  • Place of Presentation: 山崎記念館(熊本市)
  • Year and Date: 2010-06-19
• [Presentation] Regulatory mechanisms of ROS-induced apoptosis and activation of the stress-responsive kinase ASK1 by the deubiquitinating enzyme USP9X (2010)
  • Author(s): Matsuzawa A
  • Organizer: Second International Symposium on Signaling Functions of Reactive Oxygen Species, Grants-in-Aid for Scientific Research on Innovative Areas, MEXT
  • Place of Presentation: Kyoto International Conference Center, Kyoto, Japan
  • Year and Date: 2010-06-18
• [Presentation] Hepatocyte-specific c-Flip-deficient mice uncover a causal link between oxidative stress and tissue repair (2010)
  • Author(s): Nakano H
  • Organizer: Second International Symposium on Signaling Functions of Reactive Oxygen Species, Grants-in-Aid for Scientific Research on Innovative Areas, MEXT
  • Place of Presentation: Kyoto International Conference Center, Kyoto, Japan
  • Year and Date: 2010-06-18
• [Presentation] Chemical basis for mechanism of 8-nitroguanosine 3',5'-cyclic monophosohate formation in cells (2010)
  • Author(s): Ahmed K.A., et al
  • Organizer: 6th International Conference on Biology, Chemistry and Therapeutic applications of NO 2010
  • Place of Presentation: 国立京都国際会館(京都市)
  • Year and Date: 2010-06-16
• [Presentation] Detection of protein-bound 3-nitrotyrosine in plasma from pediatric patients with fulminant ARDS and avian influenza infection (2010)
  • Author(s): Okamoto T., et al
  • Organizer: 6th International Conference on Biology, Chemistry and Therapeutic applications of NO 2010
  • Place of Presentation: 国立京都国際会館(京都市)
  • Year and Date: 2010-06-16
• [Presentation] Guanine nitration and oxidative stress responses during influenza virus pneumonia in mice (2010)
  • Author(s): Khan S., et al
  • Organizer: 6th International Conference on Biology, Chemistry and Therapeutic applications of NO 2010
  • Place of Presentation: 国立京都国際会館(京都市)
  • Year and Date: 2010-06-16
• [Presentation] Nitration of 3',5'-cyclic guanylic acid, a bacterial signaling molecule (2010)
  • Author(s): Ono K., et al
  • Organizer: 6th International Conference on Biology, Chemistry and Therapeutic applications of NO 2010
  • Place of Presentation: 国立京都国際会館(京都市)
  • Year and Date: 2010-06-16
• [Presentation] Estrogen receptor-dependent or-independent suppression of NO production and 8-nitroguanosine formation by endocrine-disrupting chemicals (2010)
  • Author(s): Yoshitake J., et al
  • Organizer: 6th International Conference on Biology, Chemistry and Therapeutic applications of NO 2010
  • Place of Presentation: 国立京都国際会館(京都市)
  • Year and Date: 2010-06-16
• [Presentation] Proteomic identification for sulfhydryl modifications of mitochondrial proteins by 8-nitroguanosine 3',5'-cyclic monophosphate (2010)
  • Author(s): Rahaman M.M., et al
  • Organizer: 6th International Conference on Biology, Chemistry and Therapeutic applications of NO 2010
  • Place of Presentation: 国立京都国際会館(京都市)
  • Year and Date: 2010-06-16
• [Presentation] Activation mechanism ofcGMP-dependent protein kinase by a nitrated derivative of cGMP (2010)
  • Author(s): Oyama K., et al
  • Organizer: 6th International Conference on Biology, Chemistry and Therapeutic applications of NO 2010
  • Place of Presentation: 国立京都国際会館(京都市)
  • Year and Date: 2010-06-16
• [Presentation] Protein S-guanylation : a new post-translational regulation for redox signaling (2010)
  • Author(s): Akaike T.
  • Organizer: The 20th World Congress of the International Society for Heart Research 2010 Kyoto
  • Place of Presentation: 国立京都国際会館(京都市)
  • Year and Date: 2010-05-14
• [Presentation] A New Paradigm for Antimicrobial Host Defense Mediated by NO and ROS : A Critical Role of Nitrated Nucleotides (2010)
  • Author(s): Takaaki Akaike
  • Organizer: 第83回日本薬理学会年会
  • Place of Presentation: パシフィコ横浜(横浜市)
  • Year and Date: 2010-03-27
• [Presentation] ニトロ化環状ヌクレオチドによる蛋白質S-グアニル化を介するcGMP依存性プロテインキナーゼの活性化 (2010)
  • Author(s): 藤井重元, 他
  • Organizer: 第83回日本薬理学会年会
  • Place of Presentation: パシフィコ横浜(横浜市)
  • Year and Date: 2010-03-27
• [Presentation] Possible association of Helicobacter cinaedi with arrhythmia and atherosclerosis (2010)
  • Author(s): 岡本竜哉, 他
  • Organizer: 第83回日本薬理学会年会
  • Place of Presentation: パシフィコ横浜(横浜市)
  • Year and Date: 2010-03-27
• [Presentation] Helicobacter cinaedi-related cardiovascular diseases and atherosclerosis (2010)
  • Author(s): Okamoto T., et al.
  • Organizer: 第10回日韓国際微生物学シンポジウム
  • Place of Presentation: パシフィコ横浜(横浜市)
  • Year and Date: 2010-03-26
• [Presentation] ROS signaling in animal cells (2010)
  • Author(s): Takaaki Akaike
  • Organizer: 第51回日本植物生理学会年会
  • Place of Presentation: 熊本大学黒髪北キャンパス
  • Year and Date: 2010-03-18
• [Presentation] NO・活性酸素のヌクレオチドセンサーと親電子シグナル形成 (2010)
  • Author(s): 赤池孝章, 他
  • Organizer: 第83回日本薬理学会年会
  • Place of Presentation: 大阪国際会議場(大阪市)
  • Year and Date: 2010-03-16
• [Presentation] A unique signal transduction of NO and ROS iated by cGMP-dependent protein kinase activated via S-guanylation (2010)
  • Author(s): Ahmed KA., et al.
  • Organizer: 第26回臨床フリーラジカル会議
  • Place of Presentation: 琵琶湖ホテル(大津市)
  • Year and Date: 2010-01-29
• [Presentation] New NO signaling via 8-nitro-cGMP formation and protein S-guanylation (2009)
  • Author(s): Akaike, T
  • Organizer: 5th Joint Meeting of the Societies for Free Radical Research Australia and Japan
  • Place of Presentation: Sydney,Australia
  • Year and Date: 2009-12-04
• [Presentation] New NO signaling via 8-nitro-cGMP formation and protein S-guanylation (2009)
  • Author(s): Takaaki Akaike
  • Organizer: 5^<th> Joint Meeting of the Societies for Free Radical Research Australasia and Japan
  • Place of Presentation: University of Sydney, Sydney, Australia
  • Year and Date: 2009-12-04
• [Presentation] A unique activating mechanism of cGMP-dependent protein kinase by anitrated derivative of cGMP (2009)
  • Author(s): Oyama K., et al.
  • Organizer: 5^<th> Joint Meeting of the Societies for Free Radical Rese arch Australasia and Japan
  • Place of Presentation: University of Sydney, Sydney, Australia
  • Year and Date: 2009-12-01
• [Presentation] 活性酸素による新しい翻訳後修飾と親電子シグナル (2009)
  • Author(s): 赤池孝章, 他
  • Organizer: 大阪大学蛋白質研究セミナー
  • Place of Presentation: 大阪大学蛋白質研究所講堂
  • Year and Date: 2009-11-27
• [Presentation] An emerging pathogen, Helicobacter cinaedi : Possible association with arrhythmia and atherosclerosis (2009)
  • Author(s): Khan S., et al.
  • Organizer: 第25回熊本医学生物科学シンポジウム
  • Place of Presentation: 熊本大学山崎記念館(熊本市)
  • Year and Date: 2009-11-12
• [Presentation] A unique avtivating mechanism of Cgmp-dependent protein kinase by a nitrated derivative of cGMP (2009)
  • Author(s): Ahmed KA., et al.
  • Organizer: 第25回熊本医学生物科学シンポジウム
  • Place of Presentation: 熊本大学山崎記念館(熊本市)
  • Year and Date: 2009-11-12
• [Presentation] An emerging pathogen,Helicobacter cinaedi : Possible association with atherosclerosis (2009)
  • Author(s): Khan S., et al.
  • Organizer: 第3回細菌学・若手コロセウム
  • Place of Presentation: シーガイアサンホテルフェニックス(宮崎市)
  • Year and Date: 2009-10-26
• [Presentation] 新興感染症菌ヘリコバクター・シネディの血清診断法の確立と感染疫学への応用 (2009)
  • Author(s): 小山耕太, 他
  • Organizer: 第3回細菌学・若手コロセウム
  • Place of Presentation: シーガイアサンホテルフェニックス(宮崎市)
  • Year and Date: 2009-10-26
• [Presentation] NOと活性酸素による酸化ストレス適応応答 (2009)
  • Author(s): 赤池孝章, 他
  • Organizer: 第82回日本生化学会大会
  • Place of Presentation: 神戸ポートアイランド(神戸市)
  • Year and Date: 2009-10-21
• [Presentation] ニトロ化環状ヌクレオチドによる蛋白質S-グアニル化を介したcGMP依存性プロテインキナーゼの活性化機構 (2009)
  • Author(s): 澤智裕, 他
  • Organizer: 第82回日本生化学会大会
  • Place of Presentation: 神戸ポートアイランド(神戸市)
  • Year and Date: 2009-10-21
• [Presentation] 細胞内S-グアニル化蛋白質の同定と蛋白質S-グアニル化の生理機能の解明 (2009)
  • Author(s): 藤井重元, 他
  • Organizer: 第82回日本生化学会大会
  • Place of Presentation: 神戸ポートアイランド(神戸市)
  • Year and Date: 2009-10-21
• [Presentation] 細菌シグナル分子3^', 5^'-cyclic diguanylic acidのニトロ化 (2009)
  • Author(s): 小野勝彦, 他
  • Organizer: 第82回日本生化学会大会
  • Place of Presentation: 神戸ポートアイランド(神戸市)
  • Year and Date: 2009-10-21
• [Presentation] Chemical basis of 8-nitroguanosine 3^', 5^'-cyclic monophosphate formation in cells (2009)
  • Author(s): Ahmed KA., et al.
  • Organizer: 第82回日本生化学会大会
  • Place of Presentation: 京都府立医科大学(京都市)
  • Year and Date: 2009-10-21
• [Presentation] 活性酸素シグナル研究の新展開 (2009)
  • Author(s): 赤池孝章, 他
  • Organizer: 第13回Molecular Cardiovascular Conference
  • Place of Presentation: キロロホテルピアノ(北海道)
  • Year and Date: 2009-09-04
• [Presentation] サルモネラ感染におけるニトロ化環状ヌクレオチドを介するNO誘導性生体防御機構 (2009)
  • Author(s): 藤井重元, 他
  • Organizer: 第62回日本細菌学会九州支部総合
  • Place of Presentation: 佐賀大学医学部(佐賀市)
  • Year and Date: 2009-09-04
• [Presentation] An emerging pathogen, Helicobacter cinaedi : Possible association with atherosclerosis (2009)
  • Author(s): Khan S., et al.
  • Organizer: 第62回日本細菌学会九州支部総合
  • Place of Presentation: 佐賀大学医学部(佐賀市)
  • Year and Date: 2009-09-04
• [Presentation] 新興感染症菌ヘリコバクター・シネディの血清診断法の確立と感染疫学への応用 (2009)
  • Author(s): 小山耕太, 他
  • Organizer: 第62回日本細菌学会九州支部総合
  • Place of Presentation: 佐賀大学医学部(佐賀市)
  • Year and Date: 2009-09-04
• [Presentation] インフルエザウイルス肺炎における8-ニトロ-cGMPの生成を介した酸化ストレス応答の分子メカニズム (2009)
  • Author(s): 岡本竜哉, 他
  • Organizer: 第64回日本ウイルス学会九州支部総合
  • Place of Presentation: 佐賀大学医学部(佐賀市)
  • Year and Date: 2009-09-04
• [Presentation] Nitric oxide and electrophilic signaling mediated via 8-nitro-Cgmp (2009)
  • Author(s): Takaaki Akaike
  • Organizer: SFRR International Free Radical School in Japan 2009
  • Place of Presentation: 上越国際スキーリゾート
  • Year and Date: 2009-09-03
• [Presentation] 蛋白質S-グアニル化を介する酸化ストレス適応応答の分子機序 (2009)
  • Author(s): 藤井重元, 他
  • Organizer: 第62回Heme Oxygenase研究フォーラム
  • Place of Presentation: 京都府立医科大学(京都市)
  • Year and Date: 2009-08-31
• [Presentation] インフルエンザウイルス肺炎における8-ニトロ-cGMPの生成を介した酸化ストレス応答の分子メカニズム (2009)
  • Author(s): 岡本竜哉, 他
  • Organizer: 第20回日本生体防御学会
  • Place of Presentation: 東京医科歯科大学(東京都)
  • Year and Date: 2009-07-25
• [Presentation] Real-time imaging of various ROS and enzymatic activity in living cells byusing precisely developed novel fluorescence probes (2009)
  • Author(s): Urano Y
  • Organizer: International Symposium 2009 on Signaling Functions of Reactive Oxygen Species, Grants-in-Aid for Scientific Research on Innovative Areas, MEXT
  • Place of Presentation: Hotel Greenpia Minami-aso, Kumamoto, Japan
  • Year and Date: 2009-07-18
• [Presentation] SNO化血液製剤の薬理活性解析と臨床応用 (2009)
  • Author(s): 丸山徹, 他
  • Organizer: レッドックス生命科学第170委員会第21回研究会
  • Place of Presentation: ホテルグリーンピア南阿蘇(熊本)
  • Year and Date: 2009-07-16
• [Presentation] 新興感染症菌ヘリコバクター・シネディと院内感染 (2009)
  • Author(s): 岡本竜哉, 他
  • Organizer: 第2回感染病態研究フロンティア
  • Place of Presentation: 江陽グランドヘテル(仙台市)
  • Year and Date: 2009-07-04
• [Presentation] Impairment of NO-dependent host defense via degradation of 8-nitro-Cgmp induced by group A Streptococcus (2009)
  • Author(s): Ahmed KA., et al.
  • Organizer: 第18回Lancefieldレンサ球菌研究会
  • Place of Presentation: 九州大学(福岡市)
  • Year and Date: 2009-06-29
• [Presentation] 活性酸素による新しい翻訳後修飾とシグナル伝達機能の解明 (2009)
  • Author(s): 赤池孝章, 他
  • Organizer: 科学技術振興調整費先端融合領域イノベーション創出拠点の形成第1回公開シンポジホウム
  • Place of Presentation: 港南区民文化センターひまわりの郷(横浜市)
  • Year and Date: 2009-06-19
• [Presentation] 活性酸素とNOによる親電子シグナル伝達 (2009)
  • Author(s): 赤池孝章, 他
  • Organizer: 第62回日本酸化ストレス学会学術集会
  • Place of Presentation: 九州大学(福岡市)
  • Year and Date: 2009-06-11
• [Presentation] S-グアニル化を介したprotein kinase Gの新規な活性化機構 (2009)
  • Author(s): 澤智裕, 他
  • Organizer: 第62回日本酸化ストレス学会学術集会
  • Place of Presentation: 九州大学(福岡市)
  • Year and Date: 2009-06-11
• [Presentation] 細胞内S-グアニル化蛋白質の同定とS-グアニル化制御機構の解明 (2009)
  • Author(s): 藤井重元, 他
  • Organizer: 第62回日本酸化ストレス学会学術集会
  • Place of Presentation: 九州大学(福岡市)
  • Year and Date: 2009-06-11
• [Presentation] 8-ニトログアノシン3^',5^'-環状1リン酸による蛋白質S-グアニル化を介する酸化ストレス適応応答の分子機構 (2009)
  • Author(s): 藤井重元, 他
  • Organizer: 第9回日本NO学会総合
  • Place of Presentation: グランシップ(静岡市)
  • Year and Date: 2009-05-08
• [Presentation] インフルエンザウイルス肺炎における8-ニトロ-cGMPの生成を介した酸化ストレス応答の分子メカニズム (2009)
  • Author(s): 岡本竜哉, 他
  • Organizer: 第9回日本NO学会総合
  • Place of Presentation: グランシップ(静岡市)
  • Year and Date: 2009-05-08
• [Presentation] S-Guanylation proteomics : unique post-translational modification of thiols dependent on nitric oxide and reactive oxygen species (2009)
  • Author(s): 澤智裕, 他
  • Organizer: 第9回日本NO学会総合
  • Place of Presentation: グランシップ(静岡市)
  • Year and Date: 2009-05-08
• [Presentation] Nitration of guanosine 3^', 5^'-cyclic monophosphate by nitric oxide and reactive oxigen species (2009)
  • Author(s): Ahmed KA., et al.
  • Organizer: 第9回日本NO学会総合
  • Place of Presentation: グランシップ(静岡市)
  • Year and Date: 2009-05-08
• [Presentation] Host defense function of 8-nitro-Cgmp during murine salmonellosis (2009)
  • Author(s): Khan S., et al.
  • Organizer: 第9回日本NO学会総合
  • Place of Presentation: グランシップ(静岡市)
  • Year and Date: 2009-05-08
• [Presentation] 細菌シグナル分子3^', 5^'-cyclic diguanylic acidのニトロ化 (2009)
  • Author(s): 小山耕太, 他
  • Organizer: 第9回日本NO学会総合
  • Place of Presentation: グランシップ(静岡市)
  • Year and Date: 2009-05-08
• [Presentation] 活性酸素シグナルとオートファジー：活性酸素によるユニークな感染防御機構
  • Author(s): 赤池孝章
  • Organizer: 大阪大学微生物病研究所アドバンスセミナー
  • Place of Presentation: 大阪大学微生物病研究所 （大阪府吹田市）
  • Invited
• [Presentation] 活性酸素シグナル制御とポリサルファバイオロジー
  • Author(s): 赤池孝章
  • Organizer: 東京理科大学セミナー
  • Place of Presentation: 東京理科大学生命医科学研究所（千葉県野田市）
  • Invited
• [Presentation] 活性酸素シグナル制御とポリサルファバイオロジー
  • Author(s): 赤池孝章
  • Organizer: 国立がんセンターセミナー
  • Place of Presentation: 国立がんセンター （千葉県柏市）
  • Invited
• [Presentation] 酸化ストレスの新しい制御因子：活性イオウ分子
  • Author(s): 赤池孝章
  • Organizer: 第236回宮城県立がんセンターセミナー
  • Place of Presentation: 宮城県立がんセンター （宮城県名取市）
  • Invited
• [Presentation] 喘息を含めた呼吸器疾患と酸化ストレス
  • Author(s): 赤池孝章
  • Organizer: 第２回東北呼吸器疾患懇談会
  • Place of Presentation: AER （宮城県仙台市）
  • Invited
• [Presentation] 環境応答とチオールバイオロジー
  • Author(s): 赤池孝章
  • Organizer: 第30回高峰カンファレンス
  • Place of Presentation: 東京會館（東京都中央区）
  • Invited
• [Book] 活性酸素・ガス状分子による恒常性制御と疾患:酸化ストレス応答と低酸素センシングの最新知見からがん、免疫、代謝・呼吸・循環以上、神経変性との関わりまで.実験医学増刊 (2012)
  • Author(s): 山本雅之(監修)、赤池孝章、一條秀憲、森泰生(編集)
  • Total Pages: 217
  • Publisher: 羊土社
• [Book] イラストで徹底理解するシグナル伝達キーワード事典（山本 雅、仙波憲太郎、山梨裕司 編）NOシグナリング, p 67-69 (2012)
  • Author(s): 藤井重元
  • Total Pages: 3
  • Publisher: 羊土社
• [Book] Antioxidant adaptive response of malignant glioma related to resistance to antitumor treatment In Novel Therapeutic Concepts in Targeting Glioma, p.247-262(eds., Faris Farassati) (2011)
  • Author(s): Sawa, T., Akaike T
  • Total Pages: 15
  • Publisher: InTech (Open Access Company)
• [Book] 免疫の事典-酸化窒素nitric oxide/NO.p.39(桂義元,河本宏,小安重夫,山本一彦編) (2011)
  • Author(s): 澤智裕, 赤池孝章
  • Total Pages: 1
  • Publisher: 朝倉書店
• [Book] 免疫の事典活性酸素reactive oxygen species (ROS).p.109(桂義元,河本宏,小安重夫,山本一彦編) (2011)
  • Author(s): 澤智裕, 赤池孝章
  • Total Pages: 1
  • Publisher: 朝倉書店
• [Book] Transworld Research Network, T.C., Nitric Oxide Synthase Inhibitors : From Animal Studies to Clinical Implications (Tunctan, B., Editor) (2011)
  • Author(s): Okamoto, T., Zaki, M.H., Fujii, S., Sawa, T.
  • Publisher: Akaike, T(in press)
• [Book] Nitric Oxide Synthase Inhibitors : From Animal Studies to Clinical Implications (2011)
  • Author(s): Okamoto T., et al
  • Publisher: Nitric oxide-mediated host immune response and microbial pathogenesis(in press)
• [Book] 日本臨床増刊号 広範囲血液・尿化学検査, 免疫学的検査-4 (2010)
  • Author(s): 岡本竜哉, 他
  • Publisher: Nitric oxide(NO)およびNO関連物質
• [Book] 病態解明に迫る活性酸素シグナルと酸化ストレス:癌、神経変性疾患、循環・代謝異常にかかわるレドックス制御機構と最新の技術開発.実験医学増刊 (2009)
  • Author(s): 谷口直之(監修)、赤池孝章、鈴木敬一郎、内田浩二(編集)
  • Total Pages: 241
  • Publisher: 羊土社
  • URL: http://www.ros-signal.jp/
• [Book] 実験医学(増刊).病態解明に迫る活性酸素シグナルと酸化ストレス (2009)
  • Author(s): 谷口直之(監修)、赤池孝章、鈴木敬一郎、内田浩二(編集)
  • Total Pages: 241
  • Publisher: 羊土社
• [Book] 診断と治療社、酸化ストレスの医学 (2008)
  • Author(s): 澤智裕
  • Total Pages: 384
  • Publisher: 赤池孝章
• [Book] 酸化ストレスの医学 (2008)
  • Author(s): 澤智裕、赤池孝章
  • Total Pages: 384
  • Publisher: 診断と治療社
• [Remarks] 東北大大学院医学系研究科環境保健医学分野
  • URL: http://www.toxicosci.med.tohoku.ac.jp/index.html
• [Remarks] 熊本大学 微生物学分野
  • URL: http://kumadai-bisei.com/
• [Remarks] 文科省科研費新学術領域研究「活性酸素シグナル」
  • URL: http://www.ros-signal.jp/
• [Remarks]
  • URL: http://kumadai-bisei.com/
• [Remarks]
  • URL: http://www.ros-signal.jp/
• [Remarks]
  • URL: http://kumadai-bisei.com/
• [Remarks]
  • URL: http://www.ros-signal.jp/
• [Remarks]
  • URL: http://kumadai-bisei.com/
• [Remarks]
  • URL: http://www.ros-signal.jp