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Glia decoding: deciphering information critical for brain-body interactions

Administrative Group

Project AreaGlia decoding: deciphering information critical for brain-body interactions
Project/Area Number 20H05894
Research Category

Grant-in-Aid for Transformative Research Areas (A)

Allocation TypeSingle-year Grants
Review Section Transformative Research Areas, Section (III)
Research InstitutionThe University of Tokyo

Principal Investigator

岡部 繁男  東京大学, 大学院医学系研究科(医学部), 教授 (60204012)

Co-Investigator(Kenkyū-buntansha) 星野 歩子  東京大学, 先端科学技術研究センター, 教授 (00819964)
松田 道行  京都大学, 生命科学研究科, 教授 (10199812)
小泉 修一  山梨大学, 大学院総合研究部, 教授 (10280752)
石井 優  大阪大学, 大学院生命機能研究科, 教授 (10324758)
田中 謙二  慶應義塾大学, 医学部(信濃町), 教授 (30329700)
津田 誠  九州大学, 薬学研究院, 教授 (40373394)
史 蕭逸  筑波大学, 国際統合睡眠医科学研究機構, 助教 (40803656)
小山 隆太  国立研究開発法人国立精神・神経医療研究センター, 神経研究所 疾病研究第二部, 部長 (90431890)
和氣 弘明  名古屋大学, 医学系研究科, 教授 (90455220)
Project Period (FY) 2020-11-19 – 2025-03-31
Project Status Granted (Fiscal Year 2024)
Budget Amount *help
¥175,110,000 (Direct Cost: ¥134,700,000、Indirect Cost: ¥40,410,000)
Fiscal Year 2024: ¥17,030,000 (Direct Cost: ¥13,100,000、Indirect Cost: ¥3,930,000)
Fiscal Year 2023: ¥13,260,000 (Direct Cost: ¥10,200,000、Indirect Cost: ¥3,060,000)
Fiscal Year 2022: ¥16,120,000 (Direct Cost: ¥12,400,000、Indirect Cost: ¥3,720,000)
Fiscal Year 2021: ¥11,700,000 (Direct Cost: ¥9,000,000、Indirect Cost: ¥2,700,000)
Fiscal Year 2020: ¥117,000,000 (Direct Cost: ¥90,000,000、Indirect Cost: ¥27,000,000)
Keywordsグリア / イメージング / 神経回路 / 脳末梢連関 / 体内環境
Outline of Research at the Start

脳の広範な機能の理解には神経細胞以外の細胞要素、特に神経細胞と接して存在するグリア細胞の情報を読み出す必要がある。本領域の目標はグリア細胞の状態・機能・細胞間シグナル伝達を包括的に読み出す技術(デコーディング技術)を開発し、脳と身体の間での生体情報の統合を理解する所にある。このような研究を推進するには従来の脳科学研究の成果を踏まえつつも、全く異なるアイディアや計測技術を取り込み、異分野との連携を行う必要がある。総括班ではこのような研究の新規性、技術的優位性、異分野連携に特に力を入れて目標達成に向けた領域の推進に貢献する。

Outline of Annual Research Achievements

脳の広範な機能の理解には神経細胞以外の細胞要素、特に神経細胞と接して存在するグリア細胞の情報を読み出す必要がある。本領域の目標はグリア細胞の状態・機能・細胞間シグナル伝達を包括的に読み出す技術(デコーディング技術)を開発し、脳と身体の間での生体情報の統合を理解する所にある。このような研究を推進するため、従来の脳科学研究の成果を踏まえつつも、全く異なるアイディアや計測技術を取り込み、異分野との連携を実施している。総括班では研究の新規性、技術的優位性、異分野連携の実現に特に力を入れ、活動内容としては、(A)グリア細胞内での情報伝達の過程を読み出す技術(グリアデコーディング技術)の推進とデータ駆動型研究への適用、(B)神経回路とグリアの形成する機能単位の個体の内部環境の変化に対応した制御例の提示、(C)挑戦的かつ明確な問題設定を持った共同研究の推進、の3点を実現するための班員の連携強化を実施した。2023年度においては、具体的には国際シンポジウム等での海外研究者との交流促進、継続中の共同研究を更に加速するための支援実施、共同研究による論文成果の発表、グリア計測システムの利用促進、研究室訪問活動の充実による新たな共同研究の推進と若手研究者の支援、技術支援ワーキンググループによる情報提供や実地での技術支援が行われた。また領域内での知識の共有化を図り、領域外の研究者および市民に対してグリア研究の意義を紹介するための活動として、ウェブサイトとニュースレターによる広報などを継続した。

Current Status of Research Progress
Current Status of Research Progress

2: Research has progressed on the whole more than it was originally planned.

Reason

本領域のウェブサイトの活用、ニュースレターの発行については継続的に実施されている。第5回の班会議はオンサイトで実施し新しく採択された公募班員を含めて活発な交流が行われた。更に第6回の班会議もオンサイトで実施し、この班会議の直前に開催された財団によるグリア関連の国際シンポジウムに参加した海外の著名なグリア研究者と若手研究者の密な情報交換や共同研究の打ち合わせ等が行われた。またグリア研究に必要となるデータの蓄積や共有化が進展し、班員間でのラボビジットが頻繁に行われ、共同研究について具体化が進んだ。領域内の共同研究を加速し、領域外の研究者および市民に対してグリア研究の意義を紹介するための活動として、ウェブサイトとニュースレターによる広報も前年度に引き続き活発に行われている。

Strategy for Future Research Activity

2024年度は本領域の最終年度となるため、ウェブサイトを活用した情報共有、ニュースレター等による広報活動、公募班員への情報提供と共同研究を更に加速して、なるべく多くの論文発表を行うことを目指す。2023 年度に新たに参加した公募班員については、計画班員との連携を推進し、グリア関連のデータ共有とデータ解析に関する共同研究を促進する。若手研究者の国際交流の枠組みであるYoung Gliaを活用し、また2024年7月に企画している国際シンポジウムも利用して、海外研究者との交流を更に促進する。成果の発信とグリア研究への理解を広めるための市民公開講座等の活動も充実させる予定である。

Report

(4 results)
  • 2023 Annual Research Report
  • 2022 Annual Research Report
  • 2021 Annual Research Report
  • 2020 Annual Research Report
  • Research Products

    (74 results)

All 2023 2022 2021 2020 2019 Other

All Int'l Joint Research (2 results) Journal Article (41 results) (of which Int'l Joint Research: 22 results,  Peer Reviewed: 41 results,  Open Access: 34 results) Presentation (28 results) (of which Int'l Joint Research: 5 results,  Invited: 16 results) Book (1 results) Remarks (1 results) Funded Workshop (1 results)

  • [Int'l Joint Research] University of Colorado/Johns Hopkins School of Medicine(米国)

    • Related Report
      2020 Annual Research Report
  • [Int'l Joint Research] University of Bonn/University Dusseldorf/Max-Planck-Institute(ドイツ)

    • Related Report
      2020 Annual Research Report
  • [Journal Article] Transplantation of Human Induced Pluripotent Stem Cell-Derived Microglia in Immunocompetent Mice Brain via Non-Invasive Transnasal Route2022

    • Author(s)
      Parajuli Bijay、Shinozaki Youichi、Shigetomi Eiji、Koizumi Schuichi
    • Journal Title

      Journal of Visualized Experiments

      Volume: 183 Issue: 183

    • DOI

      10.3791/63574

    • Related Report
      2022 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] In vivo Chronic Two-Photon Imaging of Microglia in the Mouse Hippocampus2022

    • Author(s)
      Kamei Ryosuke、Urata Shinji、Maruoka Hisato、Okabe Shigeo
    • Journal Title

      Journal of Visualized Experiments

      Volume: - Issue: 185

    • DOI

      10.3791/64104

    • Related Report
      2022 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Simultaneous Imaging of Microglial Dynamics and Neuronal Activity in Awake Mice2022

    • Author(s)
      Mauoka H, Kamei R, Mizutani S, Liu Q, Okabe S
    • Journal Title

      Journal of Visualized Experiments

      Volume: 186 Issue: 186

    • DOI

      10.3791/64111

    • Related Report
      2022 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Evaluation and Manipulation of Neural Activity using Two-Photon Holographic Microscopy2022

    • Author(s)
      Kato Daisuke、Quan Xiangyu、Tanisumi Yuta、Guo Zhongtian、Morita Mitsuhiro、Takiguchi Tetsuya、Matoba Osamu、Wake Hiroaki
    • Journal Title

      Journal of Visualized Experiments

      Volume: 187 Issue: 187 Pages: 1-15

    • DOI

      10.3791/64205

    • Related Report
      2022 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] In Vivo Wide-Field and Two-Photon Calcium Imaging from a Mouse using a Large Cranial Window2022

    • Author(s)
      Manita S, Shigetomi E, Bito H, Koizumi S, Kitamura K
    • Journal Title

      Journal of Visualized Experiments

      Volume: 186 Issue: 186 Pages: 186-186

    • DOI

      10.3791/64224

    • Related Report
      2022 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Spatiotemporal Analysis of Microglial Ca2+ Activity at Single-Cell Resolution2022

    • Author(s)
      Horiuchi Hiroshi、Cheung Dennis Lawrence、Nabekura Junichi
    • Journal Title

      Journal of Visualized Experiments

      Volume: 190 Issue: 190

    • DOI

      10.3791/64300

    • Related Report
      2022 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Imaging of spine synapses using super-resolution microscopy2021

    • Author(s)
      Yutaro Kashiwagi and Shigeo Okabe
    • Journal Title

      Anatomical Science International

      Volume: ahead of print Issue: 3 Pages: 343-358

    • DOI

      10.1007/s12565-021-00603-0

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed
  • [Journal Article] The role of molecular diffusion within dendritic spines in synaptic function2021

    • Author(s)
      Obashi K, Taraska JW, Okabe S.
    • Journal Title

      Journal of General Physiology

      Volume: 153 Issue: 4

    • DOI

      10.1085/jgp.202012814

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Canonical versus non-canonical transsynaptic signaling of neuroligin 3 tunes development of sociality in mice2021

    • Author(s)
      Yoshida T, Yamagata A, Imai A, Kim J, Izumi H, Nakashima S, Shiroshima T, Maeda A, Iwasawa-Okamoto S, Azechi K, Osaka F, Saitoh T, Maenaka K, Shimada T, Fukata Y, Fukata M, Matsumoto J, Nishijo H, Takao K, Tanaka S, Okabe S, Tabuchi K, Uemura T, Mishina M, Mori H & Fukai S
    • Journal Title

      Nature Communications

      Volume: 12(1) Issue: 1 Pages: 1848-1848

    • DOI

      10.1038/s41467-021-22059-6

    • NAID

      120006996978

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Exacerbation of Epilepsy by Astrocyte Alkalization and Gap Junction Uncoupling2021

    • Author(s)
      Mariko Onodera, Jan Meyer, Kota Furukawa, Yuichi Hiraoka, Tomomi Aida, Kohichi Tanaka, Kenji F. Tanaka, Christine R. Rose and Ko Matsui
    • Journal Title

      Journal of Neuroscience

      Volume: 41 Issue: 10 Pages: 2106-2118

    • DOI

      10.1523/jneurosci.2365-20.2020

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Nitric oxide‐mediated signal transmission in bladder vasculature underlies the therapeutic actions of PDE5 inhibitors in the rat2021

    • Author(s)
      Tanaka Hidekazu、Mitsui Retsu、Oishi Mitsuhiro、Passlick Stefan、Jabs Ronald、Steinh?user Christian、Tanaka Kenji F.、Hashitani Hikaru
    • Journal Title

      British Journal of Pharmacology

      Volume: 178 Issue: 5 Pages: 1073-1094

    • DOI

      10.1111/bph.15342

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Pain induces stable, active microcircuits in the somatosensory cortex that provide a new therapeutic target.2021

    • Author(s)
      Okada T, Kato D, Nomura Y, Obata N, Quan X, Morinaga A, Yano H, Guo Z, Aoyama Y, Tachibana Y, Moorhouse AJ, Matoba O, Takiguchi T, Mizobuchi S and Wake H
    • Journal Title

      Sci Adv

      Volume: 7 Issue: 12 Pages: 8261-8261

    • DOI

      10.1126/sciadv.abd8261

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Assessing the regional impact of the Japan’s COVID-19 state of emergency declaration: a population-level observational study using social networking services2021

    • Author(s)
      Yoneoka D, Shi S, Nomura S, Tanoue Y, Kawashima T, Eguchi A, Matsuura K, Makiyama K, Uryu S, Ejima K, Sakamoto H, Taniguchi T, Kunishima H, Gilmour S, Nishiura H, Miyata H.
    • Journal Title

      BMJ Open

      Volume: 11 Issue: 2 Pages: e042002-e042002

    • DOI

      10.1136/bmjopen-2020-042002

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Reactive astrocyte nomenclature, definitions, and future directions2021

    • Author(s)
      Escartin C, Koizumi S, Verkhratsky A. et al
    • Journal Title

      Nat Neurosci

      Volume: - Issue: 3 Pages: 312-325

    • DOI

      10.1038/s41593-020-00783-4

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Reactive astrocyte-driven epileptogenesis is induced by microglia initially activated following status epilepticus2021

    • Author(s)
      Sano Fumikazu、Shigetomi Eiji、Shinozaki Youichi、Tsuzukiyama Haruka、Saito Kozo、Mikoshiba Katsuhiko、Horiuchi Hiroshi、Cheung Dennis Lawrence、Nabekura Junichi、Sugita Kanji、Aihara Masao、Koizumi Schuichi
    • Journal Title

      JCI Insight

      Volume: - Issue: 9

    • DOI

      10.1172/jci.insight.135391

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Development of a label-free ATP imaging sensor for analyzing spatiotemporal patterns of ATP resease from biological tissues.2021

    • Author(s)
      Doi H, Parajuli B, Horio T, Shigetomi E, Shinozaki Y, Noda T, Takahashi K, Hattori T, Koizumi S, Sawada T.
    • Journal Title

      Sens Act B: Chemical

      Volume: 335 Pages: 129686-129686

    • DOI

      10.1016/j.snb.2021.129686

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Group 2 innate lymphoid cells support hematopoietic recovery under stress conditions2021

    • Author(s)
      Sudo Takao、Motomura Yasutaka、Okuzaki Daisuke、Hasegawa Tetsuo、Yokota Takafumi、Kikuta Junichi、Ao Tomoka、Mizuno Hiroki、Matsui Takahiro、Motooka Daisuke、Yoshizawa Ryosuke、Nagasawa Takashi、Kanakura Yuzuru、Moro Kazuyo、Ishii Masaru
    • Journal Title

      Journal of Experimental Medicine

      Volume: 218 Issue: 5 Pages: 20200817-20200817

    • DOI

      10.1084/jem.20200817

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] SLPI is a critical mediator that controls PTH-induced bone formation2021

    • Author(s)
      Morimoto Akito、Kikuta Junichi、Nishikawa Keizo、Sudo Takao、Uenaka Maki、Furuya Masayuki、Hasegawa Tetsuo、Hashimoto Kunihiko、Tsukazaki Hiroyuki、Seno Shigeto、Nakamura Akira、Okuzaki Daisuke、Sugihara Fuminori、Ninomiya Akinori、Yoshimura Takeshi、Takao-Kawabata Ryoko、Matsuda Hideo、Ishii Masaru
    • Journal Title

      Nature Communications

      Volume: 12 Issue: 1 Pages: 2136-2136

    • DOI

      10.1038/s41467-021-22402-x

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Astrocytic cAMP modulates memory via synaptic plasticity2021

    • Author(s)
      Zhou Zhiwen、Okamoto Kazuki、Onodera Junya、Hiragi Toshimitsu、Andoh Megumi、Ikawa Masahito、Tanaka Kenji F.、Ikegaya Yuji、Koyama Ryuta
    • Journal Title

      Proceedings of the National Academy of Sciences

      Volume: 118 Issue: 3 Pages: 2016584118-2016584118

    • DOI

      10.1073/pnas.2016584118

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Microglia regulate synaptic development and plasticity2021

    • Author(s)
      Andoh M, Koyama R.
    • Journal Title

      Developmental Neurobiology

      Volume: - Issue: 5 Pages: 568-590

    • DOI

      10.1002/dneu.22814

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Assessing microglial dynamics by live imaging2021

    • Author(s)
      Andoh M, Koyama R.
    • Journal Title

      Frontiers in Immunology

      Volume: - Pages: 605-605

    • DOI

      10.3389/fimmu.2021.617564

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Retrograde ERK activation waves drive base-to-apex multicellular flow in murine cochlear duct morphogenesis2021

    • Author(s)
      Ishii M, Tateya T, Matsuda M, Hirashima T.
    • Journal Title

      eLife

      Volume: 10 Pages: 1-16

    • DOI

      10.7554/elife.61092

    • NAID

      120006976053

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Impact of exosome-mediated feto-maternal interactions on pregnancy maintenance and development of obstetric complications2021

    • Author(s)
      Hashimoto A, Sugiura K, Hoshino A.
    • Journal Title

      The Journal of Biochemistry

      Volume: 169 Issue: 2 Pages: 163-171

    • DOI

      10.1093/jb/mvaa137

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Regulation of actin dynamics in dendritic spines: Nanostructure, molecular mobility, and signaling mechanisms2020

    • Author(s)
      Okabe S.
    • Journal Title

      Molecular and Cellular Neuroscience

      Volume: 109 Pages: 103564-103564

    • DOI

      10.1016/j.mcn.2020.103564

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Geometry and the Organizational Principle of Spine Synapses along a Dendrite2020

    • Author(s)
      Parajuli Laxmi Kumar、Urakubo Hidetoshi、Takahashi-Nakazato Ai、Ogelman Roberto、Iwasaki Hirohide、Koike Masato、Kwon Hyung-Bae、Ishii Shin、Oh Won Chan、Fukazawa Yugo、Okabe Shigeo
    • Journal Title

      eneuro

      Volume: 7 Issue: 6 Pages: 0248-20

    • DOI

      10.1523/eneuro.0248-20.2020

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Intracellular ATP levels in mouse cortical excitatory neurons varies with sleep-wake states2020

    • Author(s)
      A. Natsubori, T. Tsunematsu, A. Karashima, H. Imamura, N. Kabe, A. Trevisiol, J. Hirrlinger, T. Kodama, T. Sanagi, K. Masamoto, N. Takata, K-A Nave, K. Matsui, K.F. Tanaka, M. Honda
    • Journal Title

      Communications Biology

      Volume: 3 Issue: 1 Pages: 491-491

    • DOI

      10.1038/s42003-020-01215-6

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Diffusion functional MRI reveals global brain network functional abnormalities driven by targeted local activity in a neuropsychiatric disease mouse model2020

    • Author(s)
      Abe Yoshifumi、Takata Norio、Sakai Yuki、Hamada Hiro Taiyo、Hiraoka Yuichi、Aida Tomomi、Tanaka Kohichi、Bihan Denis Le、Doya Kenji、Tanaka Kenji F
    • Journal Title

      NeuroImage

      Volume: 223 Pages: 117318-117318

    • DOI

      10.1016/j.neuroimage.2020.117318

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Maternal Immune activation induces sustained changes in fetal microglia motility2020

    • Author(s)
      Ozaki K, Kato D, Ikegami A, Hashimoto A, Sugio S, Guo Z, Shibushita M, Tatematsu T, Haruwaka K, Moorhouse AJ, Yamada H, Wake H
    • Journal Title

      Sci Rep

      Volume: 10 Issue: 1 Pages: 21378-21378

    • DOI

      10.1038/s41598-020-78294-2

    • NAID

      120006954848

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Negative feedback control of neuronal activity by microglia.2020

    • Author(s)
      Badimon A, Strasburger HJ, Ayata P, Chen X, Nair A, Ikegami A, Hwang P, Chan AT, Graves SM, Uweru JO, Ledderose C, Kutlu MG, Wheeler MA, Kahan A, Ishikawa M, Wang YC, Loh YE, Jiang JX, Surmeier DJ, Robson SC, Junger WG, Sebra R, Calipari ES, Kenny PJ, Eyo UB, Colonna M, Quintana FJ, Wake H, Gradinaru V, Schaefer A.
    • Journal Title

      Nature

      Volume: 586 Issue: 7829 Pages: 417-423

    • DOI

      10.1038/s41586-020-2777-8

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Transient microglial absence assists postmigratory cortical neurons in proper differentiation2020

    • Author(s)
      Hattori Y, Naito Y, Tsugawa Y, Nonaka S, Wake H, Nagasawa T, Kawaguchi A, Miyata T.
    • Journal Title

      Nature Communications

      Volume: 11

    • NAID

      120006841707

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Role of reactive astrocytes in the spinal dorsal horn under chronic itch conditions2020

    • Author(s)
      Shiratori-Hayashi M, Tsuda M.
    • Journal Title

      Journal of Pharmacological Sciences

      Volume: 144 Issue: 3 Pages: 147-150

    • DOI

      10.1016/j.jphs.2020.07.010

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Spinal astrocytes in superficial laminae gate brainstem descending control of mechanosensory hypersensitivity2020

    • Author(s)
      Kohro Yuta、(他20名)、Mikoshiba Katsuhiko、Taylor Verdon、Inoue Kazuhide、Tsuda Makoto
    • Journal Title

      Nature Neuroscience

      Volume: 23 Issue: 11 Pages: 1376-1387

    • DOI

      10.1038/s41593-020-00713-4

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] A large-scale epidemiological monitoring of the COVID-19 in Tokyo2020

    • Author(s)
      Yoneoka D, Tanoue Y, Kawashima T, Nomura S, Shi S, Eguchi A, Ejima K, Taniguchi T, Sakamoto H, Kunishima H, Gilmour S, Nishiura H, Miyata H.
    • Journal Title

      The Lancet Regional Health Western Pacific

      Volume: 3 Pages: 100016-100016

    • DOI

      10.1016/j.lanwpc.2020.100016

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] How Japan's state of emergency declaration for COVID-19 worked against the risk of infection: an assessment of the non-specific symptoms of 227,898 users of a social networking service2020

    • Author(s)
      Nomura S, Yoneoka D, Shi S, Tanoue Y, Kawashim T, Eguchi A, Ejima K, Taniguchi T, Sakamoto H, Kunishima H, Gilmour S, Nishiura H, Miyata H.
    • Journal Title

      The Lancet Regional Health Western Pacific

      Volume: 1 Pages: 100011-100011

    • DOI

      10.1016/j.lanwpc.2020.100011

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Impact of travel restrictions on importation of novel coronavirus infection: An effective distance approach2020

    • Author(s)
      Shi S, Tanaka S, Ueno R,Gilmour S, Tanoue Y, Kawashima T, Nomura S, Miyata H, Yoneoka D.
    • Journal Title

      Bull World Health Organ.

      Volume: 98 Issue: 8 Pages: 518-529

    • DOI

      10.2471/blt.20.255679

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Trend change of transmission route of COVID-19 related symptom in Japan2020

    • Author(s)
      Eguchi A, Yoneoka D, Shi S, Tanoue Y, Kawashima T, Nomura S, Matsuura K, Makiyama K, Ejima K, Gilmour S, Nishiura H, Miyata H.
    • Journal Title

      Public Health

      Volume: 187 Pages: 157-160

    • DOI

      10.1016/j.puhe.2020.08.020

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] A live imaging-friendly slice culture method using collagen membranes2020

    • Author(s)
      Ogaki A, Araki T, Ishikawa M, Ikegaya Y, Koyama R.
    • Journal Title

      Neuropsychopharmacology Reports

      Volume: 40 Issue: 3 Pages: 307-313

    • DOI

      10.1002/npr2.12128

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Neuronal brain-derived neurotrophic factor manipulates microglial dynamics2020

    • Author(s)
      Onodera J, Nagata H, Nakashima A, Ikegaya Y, Koyama R.
    • Journal Title

      Glia

      Volume: 69 Issue: 4 Pages: 890-904

    • DOI

      10.1002/glia.23934

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Extracellular vesicle and particle isolation from human and murine cell lines, tissues, and bodily fluids2020

    • Author(s)
      Bojmar L, Kim HS, Tobias GC, Pelissier Vatter FA, Lucotti S, Gyan KE, Kenific CM, Wan Z, Kim KA, Kim D, Hernandez J, Pascual V, Heaton TE, La Quaglia MP, Kelsen D, Trippett TM, Jones DR, Jarnagin WR, Matei IR, Zhang H, Hoshino A, Lyden D.
    • Journal Title

      STAR Protocols

      Volume: 2 Issue: 1 Pages: 100225-100225

    • DOI

      10.1016/j.xpro.2020.100225

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Extracellular vesicle and particle biomarkers define multiple human cancers2020

    • Author(s)
      Hoshino A, Kim HS, Bojmar L, Gyan E.K, Cioffi M, Hernandez J, Zambirinis CP, Rodrigues G, Molina H, Heissel S, Lyden D, et al.
    • Journal Title

      Cell

      Volume: 182 Issue: 4 Pages: 1044-1061

    • DOI

      10.1016/j.cell.2020.07.009

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Motor learning requires myelination to reduce asynchrony and spontaneity in neural activity2019

    • Author(s)
      Kato Daisuke、Wake Hiroaki、Lee Philip R.、Tachibana Yoshihisa、Ono Riho、Sugio Shouta、Tsuji Yukio、Tanaka Yasuyo H.、Tanaka Yasuhiro R.、Masamizu Yoshito、Hira Riichiro、Moorhouse Andrew J.、Tamamaki Nobuaki、Ikenaka Kazuhiro、Matsukawa Noriyuki、Fields R. Douglas、Nabekura Junichi、Matsuzaki Masanori
    • Journal Title

      Glia

      Volume: 68 Issue: 1 Pages: 193-210

    • DOI

      10.1002/glia.23713

    • NAID

      120006775953

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Presentation] Toward understanding multicellular circuit dynamics2022

    • Author(s)
      Hiroaki WAKE
    • Organizer
      Germany-Japan collaboration symposium, Heterogeneity of Glia Functions in Development and Disease
    • Related Report
      2022 Annual Research Report
  • [Presentation] Dendritic spines; nanostructure and molecular mobility2021

    • Author(s)
      Shigeo Okabe
    • Organizer
      LFD Seminar Series
    • Related Report
      2020 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] 神経回路はどのように成熟するのか‐イメージングからわかってきたこと2021

    • Author(s)
      岡部繁男
    • Organizer
      第126回日本解剖学会総会・全国学術集会、第98回日本生理学会大会 合同大会
    • Related Report
      2020 Annual Research Report
    • Invited
  • [Presentation] Opposing ventral striatal medium spiny neuron activities are shaped by striatal Pvalb-expressing interneurons during goal-directed behaviors2021

    • Author(s)
      田中謙二
    • Organizer
      第126回日本解剖学会・第98回日本生理学会 合同大会
    • Related Report
      2020 Annual Research Report
  • [Presentation] グリアのプリン作動性シグナルとうつ病2021

    • Author(s)
      小泉修一
    • Organizer
      第94回日本薬理学会年会
    • Related Report
      2020 Annual Research Report
  • [Presentation] 蛍光生体イメージングで解く免疫・骨における細胞動態ネットワークの世界2021

    • Author(s)
      石井 優
    • Organizer
      第20回日本再生医療学会総会
    • Related Report
      2020 Annual Research Report
    • Invited
  • [Presentation] リウマチ炎症・骨破壊の実体の解明~TNF 阻害剤などのバイオ製剤の新たな可能性~2021

    • Author(s)
      石井 優
    • Organizer
      第61回九州リウマチ学会
    • Related Report
      2020 Annual Research Report
    • Invited
  • [Presentation] 神経回路形成におけるマイクログリアの役割2021

    • Author(s)
      小山隆太
    • Organizer
      第74回日本小児神経学会関東地方会
    • Related Report
      2020 Annual Research Report
    • Invited
  • [Presentation] てんかんとグリア2021

    • Author(s)
      小山隆太
    • Organizer
      第15回てんかん学研修セミナー
    • Related Report
      2020 Annual Research Report
    • Invited
  • [Presentation] アストロサイトのcAMP操作による記憶の調節2021

    • Author(s)
      小山隆太
    • Organizer
      第126回日本解剖学会総会・第98回日本生理学会大会
    • Related Report
      2020 Annual Research Report
  • [Presentation] 先端光学顕微鏡技術を活用した神経回路研究2020

    • Author(s)
      岡部繁男
    • Organizer
      先端顕微鏡技術セミナー
    • Related Report
      2020 Annual Research Report
    • Invited
  • [Presentation] 血管壁細胞の光操作2020

    • Author(s)
      田中謙二
    • Organizer
      第63回 日本脳循環代謝学会
    • Related Report
      2020 Annual Research Report
  • [Presentation] 脳免疫細胞ミクログリアの生理機能と病態への寄与2020

    • Author(s)
      和氣弘明
    • Organizer
      第41回本炎症・再生医学会
    • Related Report
      2020 Annual Research Report
  • [Presentation] ミクログリアによる微小脳環境の創造的破壊2020

    • Author(s)
      和氣弘明
    • Organizer
      第43回日本神経科学大会
    • Related Report
      2020 Annual Research Report
  • [Presentation] 神経細胞の計測・操作一体型顕微鏡の開発2020

    • Author(s)
      和氣弘明
    • Organizer
      第43回日本神経科学大会
    • Related Report
      2020 Annual Research Report
  • [Presentation] 解き明かされる環境依存的可変型ミクログリアの生理機能2020

    • Author(s)
      和氣弘明
    • Organizer
      第63回日本神経化学会大会
    • Related Report
      2020 Annual Research Report
  • [Presentation] 神経障害性疼痛とミクログリア ~過去,現在,そして今後~2020

    • Author(s)
      津田誠
    • Organizer
      第42回日本疼痛学会
    • Related Report
      2020 Annual Research Report
    • Invited
  • [Presentation] グリア細胞による脳機能の制御2020

    • Author(s)
      小泉修一
    • Organizer
      第43回日本神経科学大会
    • Related Report
      2020 Annual Research Report
    • Invited
  • [Presentation] うつ病分子病態におけるグリア細胞の異常2020

    • Author(s)
      小泉修一
    • Organizer
      NPBPPP2020合同年会
    • Related Report
      2020 Annual Research Report
  • [Presentation] ミクログリア制御と脳機能2020

    • Author(s)
      小泉修一
    • Organizer
      第63回日本神経化学会大会
    • Related Report
      2020 Annual Research Report
  • [Presentation] 大脳皮質グリア細胞による神経障害性疼痛の誘導2020

    • Author(s)
      小泉修一
    • Organizer
      日本ペインクリニック学会学術集会
    • Related Report
      2020 Annual Research Report
    • Invited
  • [Presentation] マイクログリアによる脳機能の調節とiCellミクログリアの利用2020

    • Author(s)
      小山隆太
    • Organizer
      第63回日本神経化学大会
    • Related Report
      2020 Annual Research Report
    • Invited
  • [Presentation] 脳内免疫細胞マイクログリアによるシナプスのトロゴサイトーシス2020

    • Author(s)
      小山隆太
    • Organizer
      第43回日本分子生物学会年会
    • Related Report
      2020 Annual Research Report
  • [Presentation] 自閉症児血漿由来エクソソームのシグネチャー解析2020

    • Author(s)
      星野 歩子
    • Organizer
      第43回日本神経科学大会
    • Related Report
      2020 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] がんにおけるエクソソームのプロテオミクス: 転移寄与分子とがん診断バイオマーカーの解析2020

    • Author(s)
      星野 歩子
    • Organizer
      第79回日本癌学会学術総会
    • Related Report
      2020 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Exosomal proteins in disease etiology and detection2020

    • Author(s)
      星野 歩子
    • Organizer
      第93回日本生化学会大会
    • Related Report
      2020 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Cancer exosomal protein signatures: mechanistic insights and biomarker potential2020

    • Author(s)
      星野 歩子
    • Organizer
      第4回 バイオ医薬 EXPO
    • Related Report
      2020 Annual Research Report
    • Invited
  • [Presentation] Role of exosomal proteins for cancer detection and pre-metastatic niche formation2020

    • Author(s)
      星野 歩子
    • Organizer
      第43回日本分子生物学会年会
    • Related Report
      2020 Annual Research Report
    • Int'l Joint Research / Invited
  • [Book] 実験医学 脳転移性がん細胞由来エクソソーム中のタンパク質CEMIPはがん脳転移を促進する2020

    • Author(s)
      杉浦圭、橋本彩子、星野歩子
    • Total Pages
      145
    • Publisher
      羊土社
    • ISBN
      9784758125307
    • Related Report
      2020 Annual Research Report
  • [Remarks] グリアデコーディング:脳-身体連関を規定するグリア情報の読み出しと理解

    • URL

      https://gliadecode.com/

    • Related Report
      2023 Annual Research Report 2022 Annual Research Report 2021 Annual Research Report 2020 Annual Research Report
  • [Funded Workshop] Cold Spring Harbor Conreference Asia2023

    • Related Report
      2023 Annual Research Report

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Published: 2020-11-24   Modified: 2024-12-25  

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