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Target recognition and expression mechanism of intrinsically disordered protein

Administrative Group

Project AreaTarget recognition and expression mechanism of intrinsically disordered protein
Project/Area Number 21113001
Research Category

Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)

Allocation TypeSingle-year Grants
Review Section Biological Sciences
Research InstitutionYokohama City University

Principal Investigator

SATO Mamoru  横浜市立大学, その他の研究科, 教授 (60170784)

Co-Investigator(Kenkyū-buntansha) SHIBATA Takehiko  理化学研究所, 遺伝制御科学特別研究ユニット, ユニットリーダー (70087550)
OTA Motonori  名古屋大学, 大学院情報科学研究科, 教授 (40290895)
AKASHI Satoko  横浜市立大学, 大学院生命医科学研究科, 准教授 (10280728)
ISHONO Yoshizumi  九州大学, 大学院農学研究院, 教授 (30346837)
HIGO Jyunichi  大阪大学, 蛋白質研究所, 特任研究員 (80265719)
NISHIMURA Yoshifumi  横浜市立大学, 大学院生命医科学研究科, 教授 (70107390)
Co-Investigator(Renkei-kenkyūsha) FUJII Yoshiaki  東北大学/東京医科歯科大学, 難治疾患研究所, 名誉教授/客員教授 (00098146)
ISHIKAWA Fuyuki  京都大学, 大学院生命科学研究科, 教授 (30184493)
NAKAMURA Haruki  大阪大学, 蛋白質研究所, 教授 (80134485)
MORIKAWA Kousuke  国際高等研究所, チーフリサーチフェロー (80012665)
Project Period (FY) 2009-07-23 – 2014-03-31
Project Status Completed (Fiscal Year 2013)
Budget Amount *help
¥36,790,000 (Direct Cost: ¥28,300,000、Indirect Cost: ¥8,490,000)
Fiscal Year 2013: ¥5,980,000 (Direct Cost: ¥4,600,000、Indirect Cost: ¥1,380,000)
Fiscal Year 2012: ¥9,100,000 (Direct Cost: ¥7,000,000、Indirect Cost: ¥2,100,000)
Fiscal Year 2011: ¥5,980,000 (Direct Cost: ¥4,600,000、Indirect Cost: ¥1,380,000)
Fiscal Year 2010: ¥9,100,000 (Direct Cost: ¥7,000,000、Indirect Cost: ¥2,100,000)
Fiscal Year 2009: ¥6,630,000 (Direct Cost: ¥5,100,000、Indirect Cost: ¥1,530,000)
Keywords天然変性タンパク質 / X線小角散乱 / 高速AFM / NMR / 核内タンパク質 / X線小角散乱 / タンパク質のゆらぎ / ダイナミクス / ハブタンパク質 / タンパク質のダイナミクス
Research Abstract

The management group has supported with every aspect so that scientists in the fields of structure biology, molecular biology and bioinformatics within this innovated research project can work together to elucidate the structures and properties of intrinsically disordered proteins. In fact, the group has annually held several management and research meetings, and has given appropriate advice to all the research groups within this research project. Also, the management group has planned special workshops for young researcher resource development within the research duration of five years as well as international symposia and open symposia in annual meetings of several scientific societies.

Report

(6 results)
  • 2013 Annual Research Report   Final Research Report ( PDF )
  • 2012 Annual Research Report
  • 2011 Annual Research Report
  • 2010 Annual Research Report
  • 2009 Annual Research Report
  • Research Products

    (98 results)

All 2014 2013 2012 2011 2010 2009 Other

All Journal Article (21 results) (of which Peer Reviewed: 20 results,  Open Access: 3 results) Presentation (65 results) (of which Invited: 4 results) Book (5 results) Remarks (7 results)

  • [Journal Article] Distinct features of the histone core structure in nucleosomes containing the histone H2A.B variant.2014

    • Author(s)
      Sugiyama M, Arimura Y, Shirayama K, Fujita R, Oba Y, Sato N, Inoue R, Oda T, Sato M, Heenan RK, Kurumizaka H.
    • Journal Title

      Biophys J.

      Volume: 106 Issue: 10 Pages: 2206-2213

    • DOI

      10.1016/j.bpj.2014.04.007

    • Related Report
      2013 Final Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Functional analyses of the C terminal half of the Saccharomyces cerevisiae Rad52 protein2014

    • Author(s)
      Kagawa, W., Arai, N., Ichikawa, Y., Saito, K., Sugiyama, S., Saotome, M., Shibata, T. and Kurumizaka, H.
    • Journal Title

      Nucleic Acids Res

      Volume: 42 Issue: 2 Pages: 941-951

    • DOI

      10.1093/nar/gkt986

    • Related Report
      2013 Annual Research Report 2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] IDEAL in 2014 illustrates interaction networks composed of intrinsically disordered proteins and their binding partners2014

    • Author(s)
      Fukuchi, S., Amemiya, T., Sakamoto, S., Nobe, Y., Hosoda, K., Kado, Y., Murakami, S.D., Koike, R., Hiroaki, H., and Ota, M.
    • Journal Title

      Nucleic Acids Res.

      Volume: 42 Issue: D1 Pages: D320-D325

    • DOI

      10.1093/nar/gkt1010

    • Related Report
      2013 Annual Research Report 2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Hierarchical description and extensive classification of protein structural changes by Motion Tree2014

    • Author(s)
      Koike, R., Ota, M., and Kidera, A.
    • Journal Title

      J. Mol. Biol

      Volume: 426 Issue: 3 Pages: 752-762

    • DOI

      10.1016/j.jmb.2013.10.034

    • Related Report
      2013 Annual Research Report 2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Structural basis of a nucleosome containing histone H2A. B/H2A. Bbd that transiently associates with reorganized chromatin.2013

    • Author(s)
      Arimura Y., Kimura H., Oda T., Sato K., Osakabe A., Tachiwana H., Sato Y., Kinugasa Y., Ikura T., Sugiyama M., Sato M., Kurumizaka H.
    • Journal Title

      Sci Rep.

      Volume: 3 Issue: 1 Pages: 3510-3510

    • DOI

      10.1038/srep03510

    • Related Report
      2013 Final Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Putative antirecombinase Srs2 DNA helicase promotes noncrossover homologous recombination avoiding loss of heterozygosity2013

    • Author(s)
      Miura, T., Shibata, T. and Kusano, K.
    • Journal Title

      Proc Natl Acad Sci USA

      Volume: 110 Issue: 40 Pages: 16067-16072

    • DOI

      10.1073/pnas.1303111110

    • Related Report
      2013 Annual Research Report 2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Report of the wwPDB Small-Angle Scattering Task Force : Data Requirements for Biomolecular Modeling and the PDB2013

    • Author(s)
      J.Trewhella, W.A.Hendrickson, G.J.Kleywegt, A.Sali, M.Sato, T.Schwede, D.I.Svergun, J.A.Tainer, J.Westbrook, and H.M.Berman
    • Journal Title

      Structure

      Volume: 21 Issue: 6 Pages: 875-881

    • DOI

      10.1016/j.str.2013.04.020

    • Related Report
      2013 Annual Research Report 2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Accidental interaction between PDZ domains and diclofenac revealed by NMR-assisted virtual screening2013

    • Author(s)
      Tenno, T., Goda, N., Umetsu, Y., Ota, M., Kinoshita, K., and Hiroaki, H.
    • Journal Title

      Molecules

      Volume: 18 Issue: 8 Pages: 9567-9581

    • DOI

      10.3390/molecules18089567

    • Related Report
      2013 Annual Research Report 2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Conclusive evidence of the reconstituted hexasome proven by native mass spectrometry2013

    • Author(s)
      Azegami, N., Saikusa, K., Todokoro, Y., Nagadoi, A., Kurumizaka, H., Nishimura, Y., and Akashi, S.
    • Journal Title

      Biochemistry

      Volume: 52 Issue: 31 Pages: 5155-5157

    • DOI

      10.1021/bi4005655

    • Related Report
      2013 Annual Research Report 2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Gas-phase structure of the histone multimers characterized by ion mobility mass spectrometry and molecular dynamics simulation2013

    • Author(s)
      Saikusa K, Fuchigami S, Takahashi K, Asano Y, Nagadoi A, Tachiwana H, Kurumizaka H, Ikeguchi M, Nishimura Y, Akashi S
    • Journal Title

      Anal Chem

      Volume: 85 Issue: 8 Pages: 4165-4171

    • DOI

      10.1021/ac400395j

    • Related Report
      2013 Annual Research Report 2013 Final Research Report 2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] A virtual-system coupled multicanonical molecular dynamics simulation : Principles and applications to free-energy landscape of protein-protein interaction with an all-atom model in explicit solvent2013

    • Author(s)
      J. Higo, K. Umezawa, H. Nakamura
    • Journal Title

      Journal of Chemical Physics

      Volume: 138 Issue: 18 Pages: 184106-184106

    • DOI

      10.1063/1.4803468

    • Related Report
      2013 Annual Research Report 2013 Final Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Crystal structure of Cex1p reveals the mechanism of tRNA trafficking between nucleus and cytoplasm2013

    • Author(s)
      K. Nozawa, R. Ishitani, T. Yoshihisa, M. Sato, F. Arisaka, S. Kanamaru, N. Dohmae, D. Mangroo, B. Senger, H. D. Becker and O. Nureki
    • Journal Title

      Nucleic Acids Research

      Volume: 41 Issue: 6 Pages: 3901-3914

    • DOI

      10.1093/nar/gkt010

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] A virtual-system coupled multicanonical molecular dynamics simulation: Principle and its application to free-energy landscape of protein-protein interaction with an all-atom model in explicit solvent2013

    • Author(s)
      Junichi Higo
    • Journal Title

      J. Chem. Phys.

      Volume: 138

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Frustration-induced protein intrinsic disorder2013

    • Author(s)
      Matsushita, K., Kikuchi, M
    • Journal Title

      J. Chem. Phys

      Volume: 138 Issue: 10 Pages: 105101-105101

    • DOI

      10.1063/1.4794781

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Multicanonical Simulation of Coupled Folding and Binding of Intrinsically Disordered Protein using an Ising- Like Protein Model2013

    • Author(s)
      Katsuyoshi Matsushita
    • Journal Title

      Journal of Physics

      Volume: 未定

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Recognition of modification status on a histone H3 tail by linked histone reader modules of the epigenetic regulator UHRF12012

    • Author(s)
      K.Arita, S.Isogai, T.Oda, M.Unoki, K.Sugita, N.Sekiyama, K.Kuwata, R.Hamamoto, H.Tochio, M.Sato, M.Ariyoshi, and M.Shirakawa
    • Journal Title

      Proc. Natl. Acad. Sci. USA

      Volume: 109 Issue: 32 Pages: 12950-12955

    • DOI

      10.1073/pnas.1203701109

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Functions of homo- and hetero-oligomers of human Nucleoplasmin/Nucleophosmin family proteins NPM1, NPM2, and NPM3 during sperm chromatin remodeling2012

    • Author(s)
      Okuwaki M, Sumi A, Hisaoka M, Saotome-Nakamura A, Akashi S, Nishimura Y, Nagata K
    • Journal Title

      Nucleic Acids Res

      Volume: 40 Issue: 11 Pages: 4861-4878

    • DOI

      10.1093/nar/gks162

    • Related Report
      2013 Final Research Report 2012 Annual Research Report 2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Homologous recombination via synthesis-dependent strand annealing in yeast requires the Irc20 and Srs2 DNA helicases2012

    • Author(s)
      Miura, T., Yamana Y, Usui, T., Ogawa, H.I., Yamamoto, M.T., and Kusano, K.
    • Journal Title

      Genetics

      Volume: 191 Pages: 65-78

    • Related Report
      2013 Final Research Report 2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Virtual states introduced for overcoming entropic barriers in conformational space2012

    • Author(s)
      Higo, J., Nakamura, H
    • Journal Title

      BIOPHYSICS

      Volume: 8 Issue: 0 Pages: 139-144

    • DOI

      10.2142/biophysics.8.139

    • NAID

      130002061588

    • ISSN
      1349-2942
    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Vital role of the second DNA-binding site of Rad52 in yeast homologous recombination2011

    • Author(s)
      Naoto Arai, Wataru Kagawa, Kengo Saito, Yoshinori Shingu, Tsutomu Mikawa, Hitoshi Kurumizaka, Takehiko Shibata
    • Journal Title

      The Journal of Biological Chemistry

      Volume: 286 Issue: 20 Pages: 17607-17617

    • DOI

      10.1074/jbc.m110.216739

    • Related Report
      2013 Final Research Report 2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 天然変性タンパク質:タンパク質の構造・機能研究の新しいターゲット-X線小角散乱と分子動力学シミュレーションによる動的構造解析-2011

    • Author(s)
      苙口友隆、池口満徳、佐藤衛
    • Journal Title

      実験医学

      Volume: 29 Pages: 475-480

    • Related Report
      2010 Annual Research Report
  • [Presentation] MS と SAXS を組み合わせたタンパク質の解析2014

    • Author(s)
      明石知子
    • Organizer
      SPRUC拡大研究会・SPring-8利用ワークショップ
    • Place of Presentation
      SPring-8
    • Related Report
      2013 Annual Research Report
    • Invited
  • [Presentation] RecA のL1 loop 領域はDNA結合を制御する2013

    • Author(s)
      篠原魁、井川粛子、岩崎わかな、美川務、柴田武彦
    • Organizer
      第36回日本分子生物学会
    • Place of Presentation
      神戸ポートアイランド
    • Year and Date
      2013-12-05
    • Related Report
      2013 Final Research Report
  • [Presentation] Molecular mechanism of the recombination mediator activity of Rad522013

    • Author(s)
      Kagawa, Wataru
    • Organizer
      The 2nd International Symposium on Intrinsically Disordered Proteins
    • Place of Presentation
      RIKEN Yokohama Institute, Main lecture hall
    • Year and Date
      2013-01-23
    • Related Report
      2012 Annual Research Report
  • [Presentation] A general reguratory function of N-terminal intrinsically disordered regions of RecA/Rad51 recombinases in homologous DNA recombination2013

    • Author(s)
      Arai, Naoto
    • Organizer
      The 2nd International Symposium on Intrinsically Disordered Proteins
    • Place of Presentation
      RIKEN Yokohama Institute, Main lecture hall
    • Year and Date
      2013-01-23
    • Related Report
      2012 Annual Research Report
  • [Presentation] 天然変性領域をターゲットにした抗体医薬の創成を目指して2013

    • Author(s)
      佐藤 衛
    • Organizer
      第13回日本蛋白質科学会年会
    • Place of Presentation
      とりぎん文化会館
    • Related Report
      2013 Annual Research Report 2013 Final Research Report
  • [Presentation] 神経疾患における天然変性タンパク質の認識と創薬2013

    • Author(s)
      西村善文
    • Organizer
      第13回日本蛋白質科学会年会
    • Place of Presentation
      とりぎん文化会館
    • Related Report
      2013 Annual Research Report 2013 Final Research Report
  • [Presentation] REV7-REV3 複合体構造から示唆されるREV7/Mad2L2 と赤痢菌タンパク質IpaB との相互作用2013

    • Author(s)
      菊池壮太郎、原幸大、清水敏之、佐藤 衛、橋本 博
    • Organizer
      第13回日本蛋白質科学会年会
    • Place of Presentation
      とりぎん文化会館
    • Related Report
      2013 Final Research Report
  • [Presentation] Protein dynamics investigated by SAXS and MD simulation2013

    • Author(s)
      Mamoru Sato
    • Organizer
      International Conference on Structural Genomics-Structural Life Science-
    • Place of Presentation
      Keio Plaza Hotel Sapporo
    • Related Report
      2013 Final Research Report
  • [Presentation] Protein Dynamics Investigated by SAXS and MD Simulation2013

    • Author(s)
      Mamoru Sato
    • Organizer
      International Conference on Structural Genomics-Structural Life Science-(ICSG2013-SLS)
    • Place of Presentation
      Keio Plaza Hotel Sapporo in Sapporo
    • Related Report
      2013 Annual Research Report
    • Invited
  • [Presentation] 天然変性タンパク質(領域)をターゲットにした創薬2013

    • Author(s)
      佐藤 衛
    • Organizer
      静岡県立大学薬学部第238回月例薬学セミナー
    • Place of Presentation
      静岡県立大学小講堂
    • Related Report
      2013 Annual Research Report
    • Invited
  • [Presentation] RecAのL1 loop領域はDNA結合を制御する2013

    • Author(s)
      篠原 赳, 井川 粛子, 岩崎 わかな, 美川 務, 柴田 武彦
    • Organizer
      第36回日本分子生物学会年会
    • Place of Presentation
      神戸ポートアイランド
    • Related Report
      2013 Annual Research Report
  • [Presentation] 組換え修復における修復DNA合成なしの第2端捕捉モデル2013

    • Author(s)
      柴田 武彦, 篠原 赳, 草野 好司
    • Organizer
      第22回DNA複製・組換え・修復ワークショップ
    • Place of Presentation
      ホテルニュー水戸屋(仙台)
    • Related Report
      2013 Annual Research Report
  • [Presentation] ゲノム不安定化防止に寄与するRecA組換え酵素のDNA結合順序決定機構2013

    • Author(s)
      柴田 武彦, 篠原 赳, 岩崎 わかな, 井川 粛子, 美川 務, 新井 直人
    • Organizer
      第31回染色体ワークショップ・第12回核ダイナミクス研究会
    • Place of Presentation
      ホテルおかだ(箱根)
    • Related Report
      2013 Annual Research Report
  • [Presentation] REV7-REV3複合体構造から示唆されるREV7/Mad2L2と赤痢菌タンパク質IpaBとの相互作用2013

    • Author(s)
      菊池 壮太郎、原 幸大、清水 敏之、佐藤 衛、橋本 博
    • Organizer
      第13回日本蛋白質科学会年会
    • Place of Presentation
      とりぎん文化会館(鳥取)
    • Related Report
      2013 Annual Research Report
  • [Presentation] Structural study on REV7, the adaptor protein coordinating REV1 and REV3 polymerase in ttanslesion DNA synthesis2013

    • Author(s)
      Sotaro Kikuchi, Kodai Hara, Toshiyuki Shimizu, Mamoru Sato, Hiroshi Hashimoto
    • Organizer
      International Conference on Structural Genomics-Structural Life Science-(ICSG2013-SLS)
    • Place of Presentation
      Keio Plaza Hotel Sapporo in Sapporo
    • Related Report
      2013 Annual Research Report
  • [Presentation] RecA組換え酵素のL1ループの制御機能2012

    • Author(s)
      柴田 武彦
    • Organizer
      第30回染色体ワークショップ/第11回核ダイナミクス研究会
    • Place of Presentation
      淡路夢舞台国際会議場
    • Year and Date
      2012-12-19
    • Related Report
      2012 Annual Research Report
  • [Presentation] 出芽酵母Rad51組換え酵素のN末端領域の機能2012

    • Author(s)
      新井 直人
    • Organizer
      第35回分子生物学会年会
    • Place of Presentation
      福岡国際会議場・マリンメッセ福岡
    • Year and Date
      2012-12-11
    • Related Report
      2012 Annual Research Report
  • [Presentation] 溶液散乱と分子動力学計算で明らかにされるタンパク質の構造揺らぎと水和構造2012

    • Author(s)
      佐藤 衛
    • Organizer
      日本中性子科学会第12回年会
    • Place of Presentation
      京都大学百周年記念時計台記念館
    • Year and Date
      2012-12-10
    • Related Report
      2012 Annual Research Report
    • Invited
  • [Presentation] What happens on the histone multimers in the gas phase?2012

    • Author(s)
      Kazumi Saikusa, Sotaro Fuchigami, Kyohei Takahashi, Yuuki Asano, Aritaka Nagadoi, Hiroaki Tachiwana, Hitoshi Kurumizaka, Mitsunori Ikeguchi, Yoshifumi Nishimura, Satoko Akashi
    • Organizer
      19th International Conference on Mass Spectrometry
    • Place of Presentation
      Kyoto International Conference Center, Kyoto
    • Year and Date
      2012-09-16
    • Related Report
      2012 Annual Research Report
  • [Presentation] Behavior of Intrinsically Disordered Regions within a Protein Complex of Swi5-Sfr1 Characterized by Ion Mobility Mass Spectrometry2012

    • Author(s)
      Kazumi Saikusa, Naoyuki Kuwabara, Yuichi Kokabu, Mamoru Sato, Hiroshi Iwasaki, Mitsunori Ikeguchi, Toshiyuki Shimizu, and Satoko Akashi
    • Organizer
      The 60th ASMS Conference on Mass Spectrometry and Allied Topics
    • Place of Presentation
      Vancouver Convention Center, Canada
    • Year and Date
      2012-05-20
    • Related Report
      2012 Annual Research Report
  • [Presentation] Intrinsically disordered regions of the proteins related to stalled replication fork repair2012

    • Author(s)
      Ishin, Y.
    • Organizer
      第34回日本分子生物学会年会
    • Place of Presentation
      京都女子大学
    • Year and Date
      2012-03-25
    • Related Report
      2011 Annual Research Report
  • [Presentation] Behavior of intrinsically disordered regions within a protein complex of Swi5-Sfr1 characterized by ion mobility mass spectroscopy2012

    • Author(s)
      Saikusa K., Kuwabara N., Kokabu Y., Sato M., Iwasaki H., Ikeguchi M. and Akashi S.
    • Organizer
      The 60^<th> ASMS Conference of Mass Spectrometry and Allied Topics
    • Place of Presentation
      Vancouver Convention Center, Canada
    • Related Report
      2013 Final Research Report
  • [Presentation] Multicanonical Simulation of Coupled Folding and Binding of Intrinsically Disordered Protein on a Lattice Gas Protein2012

    • Author(s)
      Katsuyoshi Matsushita
    • Organizer
      CCP2012
    • Place of Presentation
      ニチイ学館 ・神戸ポートアイランドセンター (兵庫県 )
    • Related Report
      2012 Annual Research Report
  • [Presentation] 天然変性タンパク質の構造ゆらぎを生かした密度変化誘起型シグナル伝達過程2012

    • Author(s)
      白井伸宙
    • Organizer
      第12回蛋白質科学会
    • Place of Presentation
      名古屋国際会議場 (愛知県 )
    • Related Report
      2012 Annual Research Report
  • [Presentation] Intrinsically disordered regions of the proteins related to stalled replication fork repair2011

    • Author(s)
      Ishino, Y.
    • Organizer
      第34回日本分子生物学会年会
    • Place of Presentation
      パシフィコ横浜
    • Year and Date
      2011-12-14
    • Related Report
      2013 Final Research Report
  • [Presentation] Toward the structural characterization of intrinsically disordered proteins by SAXS and MD simulation2011

    • Author(s)
      Sato, M.
    • Organizer
      第34回日本分子生物学会年会
    • Place of Presentation
      パシフィコ横浜
    • Year and Date
      2011-12-14
    • Related Report
      2013 Final Research Report 2011 Annual Research Report
  • [Presentation] Database for the research of intrinsically disordered proteins2011

    • Author(s)
      Ota, M.
    • Organizer
      第34回日本分子生物学会年会
    • Place of Presentation
      パシフィコ横浜
    • Year and Date
      2011-12-14
    • Related Report
      2013 Final Research Report 2011 Annual Research Report
  • [Presentation] NMR studies on chromatin-related proteins2011

    • Author(s)
      Nishimura, Y.
    • Organizer
      第34回日本分子生物学会年会
    • Place of Presentation
      パシフィコ横浜
    • Year and Date
      2011-12-14
    • Related Report
      2013 Final Research Report 2011 Annual Research Report
  • [Presentation] Local folding of the N-terminal domain of RecA upon protein-protein/protein-DNA interactions and its role2011

    • Author(s)
      Mikawa, T., Ito, Y., Shibata, T.
    • Organizer
      第34回日本分子生物学会年会
    • Place of Presentation
      パシフィコ横浜
    • Year and Date
      2011-12-14
    • Related Report
      2013 Final Research Report 2011 Annual Research Report
  • [Presentation] タンパク質複合体を観る-イオンモビリティMSの実際-2010

    • Author(s)
      明石知子
    • Organizer
      BMCシンポジウム
    • Place of Presentation
      (財)微生物化学研究会微生物化学研究所
    • Year and Date
      2010-12-11
    • Related Report
      2010 Annual Research Report
  • [Presentation] 天然変性タンパク質研究の現状と展望2010

    • Author(s)
      佐藤衛
    • Organizer
      新学術領域研究「天然変性蛋白質」第1回若手育成講習会
    • Place of Presentation
      横浜市立大学鶴見キャンパス
    • Year and Date
      2010-09-10
    • Related Report
      2010 Annual Research Report
  • [Presentation] 天然変性タンパク質(領域)の予測法2010

    • Author(s)
      福地佐斗志
    • Organizer
      新学術領域研究「天然変性蛋白質」第1回若手育成講習会
    • Place of Presentation
      横浜市立大学鶴見キャンパス
    • Year and Date
      2010-09-10
    • Related Report
      2010 Annual Research Report
  • [Presentation] 天然変性タンパク質の動的構造解析への挑戦2010

    • Author(s)
      佐藤衛
    • Organizer
      文科省「新学術領域研究(天然変性蛋白質)」第1回公開シンポジウム
    • Place of Presentation
      理化学研究所横浜研究所
    • Year and Date
      2010-01-19
    • Related Report
      2009 Annual Research Report
  • [Presentation] 組換えメディエーターの新機能探索と天然変性領域2010

    • Author(s)
      柴田武彦
    • Organizer
      文科省「新学術領域研究(天然変性蛋白質)」第1回公開シンポジウム
    • Place of Presentation
      理化学研究所横浜研究所
    • Year and Date
      2010-01-19
    • Related Report
      2009 Annual Research Report
  • [Presentation] 天然変性タンパク質のデータベース構築と解析2010

    • Author(s)
      太田元規
    • Organizer
      文科省「新学術領域研究(天然変性蛋白質)」第1回公開シンポジウム
    • Place of Presentation
      理化学研究所横浜研究所
    • Year and Date
      2010-01-19
    • Related Report
      2009 Annual Research Report
  • [Presentation] 天然変性タンパク質の構造解析-質量分析によるアプローチ-2010

    • Author(s)
      明石知子
    • Organizer
      文科省「新学術領域研究(天然変性蛋白質)」第1回公開シンポジウム
    • Place of Presentation
      理化学研究所横浜研究所
    • Year and Date
      2010-01-19
    • Related Report
      2009 Annual Research Report
  • [Presentation] DNA複製フォーク進行に関与するタンパク質の天然変性領域の役割解明を目指して2010

    • Author(s)
      石野良純
    • Organizer
      文科省「新学術領域研究(天然変性蛋白質)」第1回公開シンポジウム
    • Place of Presentation
      理化学研究所横浜研究所
    • Year and Date
      2010-01-19
    • Related Report
      2009 Annual Research Report
  • [Presentation] 天然変性蛋白質NRSFはパートナー蛋白質Sin3の存在下のみでヘリックス構造をとる-全原子マルチカノニカル計算-2010

    • Author(s)
      肥後順一
    • Organizer
      文科省「新学術領域研究(天然変性蛋白質)」第1回公開シンポジウム
    • Place of Presentation
      理化学研究所横浜研究所
    • Year and Date
      2010-01-19
    • Related Report
      2009 Annual Research Report
  • [Presentation] 天然変性タンパク質の認識機構と合理的創薬2010

    • Author(s)
      西村善文
    • Organizer
      文科省「新学術領域研究(天然変性蛋白質)」第1回公開シンポジウム
    • Place of Presentation
      理化学研究所横浜研究所
    • Year and Date
      2010-01-19
    • Related Report
      2009 Annual Research Report
  • [Presentation] 天然変性タンパク質研究 : タンパク質の構造・機能研究の新しいパラダイム2010

    • Author(s)
      佐藤 衛
    • Organizer
      第10回日本蛋白質科学会年会
    • Place of Presentation
      札幌コンベンションセンター
    • Related Report
      2013 Final Research Report
  • [Presentation] 相同組換え開始制御に働く天然変性タンパク質の機能2010

    • Author(s)
      柴田武彦
    • Organizer
      第10回日本蛋白質科学会年会
    • Place of Presentation
      札幌コンベンションセンター
    • Related Report
      2013 Final Research Report
  • [Presentation] DNA 複製フォーク進行停止の修復に関わる天然変性タンパク質2010

    • Author(s)
      石野良純
    • Organizer
      第10回日本蛋白質科学会年会
    • Place of Presentation
      札幌コンベンションセンター
    • Related Report
      2013 Final Research Report
  • [Presentation] NMR モデルを利用した天然変性領域のアサインメント2010

    • Author(s)
      太田元規
    • Organizer
      第10回日本蛋白質科学会年会
    • Place of Presentation
      札幌コンベンションセンター
    • Related Report
      2013 Final Research Report
  • [Presentation] 天然変性タンパク質の認識機構の多様性と創薬への道2010

    • Author(s)
      西村善文
    • Organizer
      第10回日本蛋白質科学会年会
    • Place of Presentation
      札幌コンベンションセンター
    • Related Report
      2013 Final Research Report
  • [Presentation] 天然変性蛋白質NRSF とパートナー蛋白質Sin3 の結合/折り畳みの自由エネルギー地形2010

    • Author(s)
      肥後順一
    • Organizer
      第10回日本蛋白質科学会年会
    • Place of Presentation
      札幌コンベンションセンター
    • Related Report
      2013 Final Research Report
  • [Presentation] 天然変性タンパク質研究:タンパク質の構造・機能研究の新しいパラダイム2010

    • Author(s)
      佐藤衛
    • Organizer
      第10回日本蛋白質科学会年会ワークショップ「天然変性タンパク質研究が目指すサイエンス」
    • Place of Presentation
      札幌コンベンションセンター
    • Related Report
      2010 Annual Research Report
  • [Presentation] 相同組換え開始制御に働く天然変性タンパク質の機能2010

    • Author(s)
      柴田武彦
    • Organizer
      第10回日本蛋白質科学会年会ワークショップ「天然変性タンパク質研究が目指すサイエンス」
    • Place of Presentation
      札幌コンベンションセンター
    • Related Report
      2010 Annual Research Report
  • [Presentation] DNA複製フォーク進行停止の修復に関わる天然変性タンパク質2010

    • Author(s)
      石野良純
    • Organizer
      第10回日本蛋白質科学会年会ワークショップ「天然変性タンパク質研究が目指すサイエンス」
    • Place of Presentation
      札幌コンベンションセンター
    • Related Report
      2010 Annual Research Report
  • [Presentation] NMRモデルを利用した天然変性領域のアサインメント2010

    • Author(s)
      太田元規
    • Organizer
      第10回日本蛋白質科学会年会ワークショップ「天然変性タンパク質研究が目指すサイエンス」
    • Place of Presentation
      札幌コンベンションセンター
    • Related Report
      2010 Annual Research Report
  • [Presentation] 天然変性タンパク質の認識機構の多様性と創薬への道2010

    • Author(s)
      西村善文
    • Organizer
      第10回日本蛋白質科学会年会ワークショップ「天然変性タンパク質研究が目指すサイエンス」
    • Place of Presentation
      札幌コンベンションセンター
    • Related Report
      2010 Annual Research Report
  • [Presentation] 天然変性蛋白質NRSFとパートナー蛋白質Sin3の結合/折り畳みの自由エネルギー地形2010

    • Author(s)
      肥後順一
    • Organizer
      第10回日本蛋白質科学会年会ワークショップ「タンパク質間相互作用の計算・情報科学」
    • Place of Presentation
      札幌コンベンションセンター
    • Related Report
      2010 Annual Research Report
  • [Presentation] 大きく揺らいでいる天然変性タンパク質の動的構造解析を目指して2010

    • Author(s)
      佐藤衛
    • Organizer
      岡崎統合バイオサイエンスセンター・サマースクール
    • Place of Presentation
      岡崎統合バイオサイエンスセンター
    • Related Report
      2010 Annual Research Report
  • [Presentation] 転写関連因子の天然変性状態2010

    • Author(s)
      西村善文
    • Organizer
      岡崎統合バイオサイエンスセンター・サマースクール
    • Place of Presentation
      岡崎統合バイオサイエンスセンター
    • Related Report
      2010 Annual Research Report
  • [Presentation] 天然変性タンパク質:バイオインフォマティクスによるアプローチ2010

    • Author(s)
      太田元規
    • Organizer
      岡崎統合バイオサイエンスセンター・サマースクール
    • Place of Presentation
      岡崎統合バイオサイエンスセンター
    • Related Report
      2010 Annual Research Report
  • [Presentation] 遺伝動態での天然変性タンパク質の働き2010

    • Author(s)
      柴田武彦
    • Organizer
      岡崎統合バイオサイエンスセンター・サマースクール
    • Place of Presentation
      岡崎統合バイオサイエンスセンター
    • Related Report
      2010 Annual Research Report
  • [Presentation] Towards the dynamical structure analysis of intrinsically disordered proteins in solution by SAXS and MD simulation2010

    • Author(s)
      Mamoru Sato
    • Organizer
      The 6th Future Light Source Workshop 2010 : Science and Technology
    • Place of Presentation
      Pohang Accelerator Laboratory, Pohang, Korea
    • Related Report
      2010 Annual Research Report
  • [Presentation] X線小角散乱法と分子動力学シミュレーションを組み合わせた天然変性タンパク質動的構造解析法の開発2009

    • Author(s)
      佐藤 衛
    • Organizer
      第82回日本生化学会年会
    • Place of Presentation
      神戸ポートアイランド
    • Related Report
      2013 Final Research Report 2009 Annual Research Report
  • [Presentation] 相同DNA 組換えにおける天然変性領域の機能2009

    • Author(s)
      柴田武彦, 新井直人, 凌 楓, 香川 亘, 胡桃坂 仁志, 井上 仁, 新宮 良宣, 美川務
    • Organizer
      第82回日本生化学会年会
    • Place of Presentation
      神戸ポートアイランド
    • Related Report
      2013 Final Research Report
  • [Presentation] 天然変性タンパク質のデータベース構築と解析2009

    • Author(s)
      太田元規、福地佐斗志
    • Organizer
      第82回日本生化学会年会
    • Place of Presentation
      神戸ポートアイランド
    • Related Report
      2013 Final Research Report 2009 Annual Research Report
  • [Presentation] マルチカノニカル分子動力学シミュレーションによる天然変性蛋白質の自由エネルギー地形2009

    • Author(s)
      肥後順一
    • Organizer
      第82回日本生化学会年会
    • Place of Presentation
      神戸ポートアイランド
    • Related Report
      2013 Final Research Report 2009 Annual Research Report
  • [Presentation] 天然変性転写関連タンパク質2009

    • Author(s)
      西村善文
    • Organizer
      第82回日本生化学会年会
    • Place of Presentation
      神戸ポートアイランド
    • Related Report
      2013 Final Research Report
  • [Presentation] 天然変性タンパク質による転写調節機構2009

    • Author(s)
      西村善文
    • Organizer
      第32回日本分子生物学会年会
    • Place of Presentation
      パシフィコ横浜
    • Related Report
      2013 Final Research Report
  • [Presentation] 相同DNA組換えにおける天然変性領域の機能2009

    • Author(s)
      柴田武彦, 新井直人, 凌楓, 香川亘, 胡桃坂仁志, 井上仁, 新宮良宣, 美川務
    • Organizer
      第82回日本生化学会年会
    • Place of Presentation
      神戸ポートアイランド
    • Related Report
      2009 Annual Research Report
  • [Presentation] 天然変性タンパク質による転写調節機構(ワークショップテーマ)2009

    • Author(s)
      西村善文
    • Organizer
      第32回日本分子生物学会年会
    • Place of Presentation
      パシフィコ横浜(神奈川県)
    • Related Report
      2009 Annual Research Report
  • [Presentation] 天然変性転写関連タンパク質2009

    • Author(s)
      西村善文
    • Organizer
      第82回日本生化学会大会
    • Place of Presentation
      神戸ポートアイランド
    • Related Report
      2009 Annual Research Report
  • [Book] Protein Conformational Dynamics in Advances in Experimental Medicine and Biology Vol.8052014

    • Author(s)
      Higo J., Umezawa K.
    • Total Pages
      21
    • Publisher
      Springer
    • Related Report
      2013 Final Research Report
  • [Book] “Protein Conformational Dynamics” in “Advances in Experimental Medicine and Biology” Vol. 8052014

    • Author(s)
      Junichi Higo, Koji Umezawa
    • Total Pages
      21
    • Publisher
      Springer
    • Related Report
      2013 Annual Research Report
  • [Book] 全原子コンピュータシミュレーションで解き明かす、天然変成タンパク質の分子認識機構2013

    • Author(s)
      肥後順一
    • Total Pages
      5
    • Publisher
      生物物理学会会誌「生物物理」
    • Related Report
      2012 Annual Research Report
  • [Book] Protein conformational dynamics : Free-energy land scope of intrinsically disordered proteins investigated by all-atom multicanonical molecular dynamics2012

    • Author(s)
      Higo J.
    • Total Pages
      10
    • Publisher
      Springer
    • Related Report
      2013 Final Research Report
  • [Book] Protein Conformational Dynamics: Free-energy landscape of Intrinsically disordered proteins investigated by all-atommulticanonical molecular dynamics2012

    • Author(s)
      Junichi Higo
    • Total Pages
      10
    • Publisher
      Springer
    • Related Report
      2012 Annual Research Report
  • [Remarks]

    • URL

      http://www.tsurumi.yokohama-cu.ac.jp/IDP/results.html

    • Related Report
      2013 Final Research Report
  • [Remarks] 新学術領域研究「天然変性タンパク質の分子認識機構と機能発現」ホームページ

    • URL

      http://www.tsurumi.yokohama-cu.ac.jp/IDP/

    • Related Report
      2013 Annual Research Report
  • [Remarks] 「天然変性タンパク質の分子認識機構と機能発現」ホームページ

    • URL

      http://www.tsurumi.yokohama-cu.ac.jp/IDP/

    • Related Report
      2012 Annual Research Report
  • [Remarks] 理化学研究所遺伝制御科学特別研究ユニット

    • URL

      http://www.riken.jp/research/labs/initiative/cell_mol_biol/

    • Related Report
      2012 Annual Research Report
  • [Remarks]

    • URL

      http://www.tsurumi.yokohama-cu.ac.jp/IDP/index.html

    • Related Report
      2011 Annual Research Report
  • [Remarks]

    • URL

      http://www.tsurumi.yokohama-cu.ac.jp/IDP/index.html

    • Related Report
      2010 Annual Research Report
  • [Remarks]

    • URL

      http://www.tsurumi.yokohama-cu.ac.jp/IDP/index.html

    • Related Report
      2009 Annual Research Report

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Published: 2009-04-01   Modified: 2023-03-16  

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