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Integrative understanding of biological processes mediated by transient macromolecul ar complexes; New technology for visualizing physiologically metastable states

Administrative Group

Project AreaIntegrative understanding of biological processes mediated by transient macromolecular complexes; New technology for visualizing physiologically metastable states.
Project/Area Number 21121001
Research Category

Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)

Allocation TypeSingle-year Grants
Review Section Complex systems
Research InstitutionThe University of Tokyo

Principal Investigator

SHIMADA Ichio  東京大学, 薬学研究科(研究院), 教授 (70196476)

Co-Investigator(Kenkyū-buntansha) KOHDA Daisuke  九州大学, 生体防御医学研究所, 教授 (80186618)
浜地 格  京都大学, 大学院・工学研究科, 教授 (90202259)
白川 昌宏  京都大学, 大学院・工学研究科, 教授 (00202119)
森川 耿右  大阪大学, タンパク質研究所, 特任研究員(客員教授) (80012665)
早坂 晴子  大阪大学, 大学院・医学系研究科, 助教 (70379246)
Co-Investigator(Renkei-kenkyūsha) FUNATSU Takashi  東京大学, 大学院薬学系研究科, 教授 (00190124)
HAMACHI Itaru  京都大学, 工学研究科, 教授 (90202259)
SHIRAKAWA Masahiro  京都大学, 工学研究科, 教授 (00202119)
HAYASAKA Haruko  大阪大学, 医学系研究科, 助教 (70379246)
AKUTSU Hideo  大阪大学, 蛋白質研究所, 客員教授 (60029965)
INAGAKI Fuyuhiko  北海道大学, 先端生命科学研究科, 教授 (70011757)
MIYASAKA Masayuki  大阪大学, 医学系研究科, 教授 (50064613)
NISHIMURA Yoshifumi  横浜市立大学, 国際総合科学部, 教授 (70107390)
MORIKAWA Kosuke  国際高等研究所, チーフリサーチフェロー (80012665)
Project Period (FY) 2009-07-23 – 2014-03-31
Project Status Completed (Fiscal Year 2014)
Keywords領域とりまとめ / 構造生物学 / 核磁気共鳴法 / X線結晶構造解析 / 一分子計測学 / ケミカルバイオロジー / X線結晶構造解析 / ケミカル・バイオロジ / ケミカルバイオロジ
Outline of Annual Research Achievements

領域まとめのシンポジウムを主催した。平成27年2月4日と5日の2日間にわたって、理化学研究所横浜事業所交流棟ホールにて開催した。
海外からの招待講演者として、Peter Wright 博士(Scripps, USA)、Angela M. Gronenborn博士 (Univ. of Pittsburgh, USA)、Tai-huang Huang博士 (Academia Sinica, Taiwan)、
Michael Sattler 博士(Technische Universitat Munchen, Germany)、Wolfgang Jahnke博士 (Novartis, Switzerland)、Mitsuhiko Ikura 博士(Univ. Toronto, Canada)、Christian Griesinger博士 (MPI, Germany)、Juli Feigon博士 (UCLA, USA)、 Bong-Jin Lee博士 (Seoul National Univ. Korea)、Philipp Selenko博士 (Leibniz Institute, Germany)を招待した。
開催に際してはHPやポスターを配布するなどして広く告知を行った。また、参加者への便宜を図るため、講演スライドのハンドアウトを参加者へ配布した。
また計画班から嶋田と白川が、公募班員の片平と児嶋がそれぞれ講演を行い、本新学術領域の成果を公表した。2日間にわたるシンポジウムを行い、134名が出席した。

Research Progress Status

26年度が最終年度であるため、記入しない。

Strategy for Future Research Activity

26年度が最終年度であるため、記入しない。

Report

(7 results)
  • 2014 Annual Research Report
  • 2013 Annual Research Report   Final Research Report ( PDF )
  • 2012 Annual Research Report
  • 2011 Annual Research Report
  • 2010 Annual Research Report
  • 2009 Annual Research Report
  • Research Products

    (135 results)

All 2015 2014 2013 2012 2011 2010 2009 Other

All Journal Article (60 results) (of which Peer Reviewed: 55 results,  Acknowledgement Compliant: 8 results,  Open Access: 2 results) Presentation (68 results) (of which Invited: 17 results) Book (1 results) Remarks (6 results)

  • [Journal Article] Suppression of problematic compound oligomerization by cosolubilization of nondetergent sulfobetaines2015

    • Author(s)
      Mizukoshi Y, Takeuchi K, Arutaki M, Takizawa T, Hanzawa H, Takahashi H, Shimada I
    • Journal Title

      ChemMedChem

      Volume: 10 Issue: 4 Pages: 736-741

    • DOI

      10.1002/cmdc.201500057

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Development of a method for reconstruction of crowded NMR spectra from undersampled time-domain data2014

    • Author(s)
      Ueda T, Yoshiura C, Matsumoto M, Kofuku Y, Okude J, Kondo K, Shiraishi Y, Takeuchi K, Shimada I.
    • Journal Title

      J Biomol NMR

      Volume: なし

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Dynamic multidrug recognition by multidrug transcriptional repressor LmrR2014

    • Author(s)
      Takeuchi K, Tokunaga Y, Imai M, Takahashi H, Shimada I.
    • Journal Title

      Sci Rep

      Volume: 4 Issue: 1 Pages: 6922-6922

    • DOI

      10.1038/srep06922

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Functional dynamics of deuterated β2 -adrenergic receptor in lipid bilayers revealed by NMR spectroscopy2014

    • Author(s)
      Kofuku Y, Ueda T, Okude J, Shiraishi Y, Kondo K, Mizumura T, Suzuki S, Shimada I
    • Journal Title

      Angew Chem Int Ed Engl

      Volume: 53 Issue: 49 Pages: 13376-13379

    • DOI

      10.1002/anie.201406603

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Structural basis for the binding of the membrane-proximal C-terminal region of chemokine receptor CCR2 with the cytosolic regulator FROUNT2014

    • Author(s)
      Esaki K, Yoshinaga S, Tsuji T, Toda E, Terashima Y, Saitoh T, Kohda D, Kohno T, Osawa M, Ueda T, Shimada I, Matsushima K, Terasawa H
    • Journal Title

      FEBS J

      Volume: 281 Issue: 24 Pages: 552-566

    • DOI

      10.1111/febs.13096

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Allosteric enhancement of MAP kinase p38α's activity and substrate selectivity by docking interactions2014

    • Author(s)
      Tokunaga Y, Takeuchi K, Takahashi H, Shimada I
    • Journal Title

      Nat Struct Mol Biol

      Volume: 21 Issue: 8 Pages: 704-711

    • DOI

      10.1038/nsmb.2861

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Cross-saturation and transferred cross-saturation experiments2014

    • Author(s)
      Ueda T, Takeuchi K, Nishida N, Stampoulis P, Kofuku Y, Osawa M, Shimada I
    • Journal Title

      Q Rev Biophys

      Volume: 47 Issue: 2 Pages: 143-187

    • DOI

      10.1017/s0033583514000043

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Structure-based approach to improve a small-molecule inhibitor by the use of a competitive peptide ligand.2014

    • Author(s)
      Ono K, Takeuchi K, Ueda H, Morita Y, Tanimura R, Shimada I, Takahashi H.
    • Journal Title

      Angew Chem Int Ed Engl

      Volume: 53 Issue: 10 Pages: 2597-2597

    • DOI

      10.1002/anie.201310749

    • Related Report
      2014 Annual Research Report 2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Functional dynamics of cell surface membrane proteins2014

    • Author(s)
      Nishida N, Osawa M, Takeuchi K, Imai S, Stampoulis P, Kofuku Y, Ueda T, Shimada I
    • Journal Title

      J Magn Reson

      Volume: 241 Pages: 86-96

    • DOI

      10.1016/j.jmr.2013.11.007

    • Related Report
      2014 Annual Research Report 2013 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Identification of a binding element for the cytoplasmic regulator FROUNTin the membrane-proximal C-terminal region of chemokine receptors CCR2 and CCR5.2014

    • Author(s)
      Toda E, Terashlma Y, Esakii K, Yoshinaga S, Sugihara M, Kofuku Y, Shimada I, Suwa M, Kanegasaki S, Terasawa H, Matsushima K.
    • Journal Title

      Biochemical Journal

      Volume: Vol.457 Issue: 2 Pages: 313-322

    • DOI

      10.1042/bj20130827

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] A Gel-Encapsulated Bioreactor System for NMR Studies of Protein-Protein Interactions in Living Mammalian Cells2013

    • Author(s)
      Satoshi Kubo, Noritaka Nishida, Yuko Udagawa, Osamu Takarada, Shinji Ogino, Ichio Shimada
    • Journal Title

      Angewandte Chemie International Edition

      Volume: 52 Issue: 4 Pages: 1208-1211

    • DOI

      10.1002/anie.201207243

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Backbone resonance assignments for the cytoplasmic region of the Mg(2+) transporter MgtE in the Mg (2+)-unbound state2013

    • Author(s)
      Maruyama T, Imai S, Osawa M, Hattori M, Ishitani R, Nureki O, Shimada I.
    • Journal Title

      Biomol NMR Assign

      Volume: 7 Issue: 1 Pages: 93-96

    • DOI

      10.1007/s12104-012-9385-y

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Structure of the Mouse Sex Peptide Pheromone ESP1 Reveals a Molecular Basis for Specific Binding to the Class C G-protein-coupled Vomeronasal Receptor2013

    • Author(s)
      Yoshinaga S, Sato T, Hirakane M, Esaki K, Hamaguchi T, Haga-Yamanaka S, Tsunoda M, Kimoto H, Shimada I, Touhara K, Terasawa H
    • Journal Title

      The Journal of Biological Chemistry

      Volume: 288 Issue: 22 Pages: 16064-72

    • DOI

      10.1074/jbc.m112.436782

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Backbone resonance assignments for G protein α(i3) subunit in the GDP-bound state2013

    • Author(s)
      Mase Y, Yokogawa M, Osawa M, Shimada I.
    • Journal Title

      Biomol NMR Assign

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Nuclear magnetic resonance approaches for characterizing interactions between the bacterial chaperonin GroEL and unstructured proteins.2013

    • Author(s)
      Nishida N, Yagi-Utsumi M, Motojima F, Yoshida M, Shimada I, Kato K.
    • Journal Title

      J Biosci Bioeng

      Volume: 116 Issue: 2 Pages: 160-164

    • DOI

      10.1016/j.jbiosc.2013.02.012

    • NAID

      110009657195

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Backbone and side-chain (1)H, (15)N and (13)C resonance assignments of the microtubule-binding domain of yeast cytoplasmic dynein in the high and low-affinity states.2013

    • Author(s)
      Takarada O, Nishida N, Kikkawa M, Shimada I.
    • Journal Title

      Biomol NMR Assign

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Perdeuteration and methyl-selective (1)H, (13)C-labeling by using a Kluyveromyces lactis expression system2013

    • Author(s)
      Miyazawa-Onami M, Takeuchi K, Takano T, Sugiki T, Shimada I, Takahashi H.
    • Journal Title

      J Biomol NMR

      Volume: 57 Issue: 3 Pages: 297-304

    • DOI

      10.1007/s10858-013-9789-8

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Rapid identification of ligand-binding sites by using an assignment-free NMR approach2013

    • Author(s)
      Kodama Y, Takeuchi K, Shimba N, Ishikawa K, Suzuki E, Shimada I, Takahashi H.
    • Journal Title

      J Med Chem

      Volume: 56 Issue: 22 Pages: 9342-9350

    • DOI

      10.1021/jm4014357

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Efficacy of the β2-adrenergic receptor is determined by conformational equilibrium in the transmembrane region2012

    • Author(s)
      Kofuku Y, Ueda T, Okude J, Shiraishi Y, Kondo K, Maeda M, Tsujishita H, Shimada I
    • Journal Title

      Nat Commun.

      Volume: 3 Issue: 1 Pages: 1045-1045

    • DOI

      10.1038/ncomms2046

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] An NMR method to study protein-protein interactions2012

    • Author(s)
      Nishida N, Shimada I.
    • Journal Title

      Methods Mol Biol

      Volume: 757 Pages: 129-137

    • DOI

      10.1007/978-1-61779-166-6_10

    • ISBN
      9781617791659, 9781617791666
    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Isotopic labeling of heterologous proteins in the yeast Pichia pastoris and Kluyveromyces lactis2012

    • Author(s)
      Sugiki T, Ichikawa O, Miyazawa-Onami M, Shimada I, Takahashi H.
    • Journal Title

      Methods Mol Biol

      Volume: 831 Pages: 19-36

    • DOI

      10.1007/978-1-61779-480-3_2

    • ISBN
      9781617794797, 9781617794803
    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Atypical membrane-embedded p47^<phox> PI(3,4)P_2 binding site on PX domain revealed by NMR2012

    • Author(s)
      Stampoulis P, Ueda T, Matsumoto M, Terasawa H, Miyano K, Sumimoto H, and Shimada I
    • Journal Title

      J. Biol. Chem

      Volume: 287 Issue: 21 Pages: 17848-17859

    • DOI

      10.1074/jbc.m111.332874

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Structural basis for the modulation of the gating property of G protein-gated inwardly rectifying potassium ion channel (GIRK)by the i/o-family G protein α subunit (Gdi_<i/o>)2012

    • Author(s)
      間瀬瑶子
    • Journal Title

      The Journal of Biological Chemistry

      Volume: 287 Issue: 23 Pages: 19537-19549

    • DOI

      10.1074/jbc.m112.353888

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Segmental isotopic labeling of a 140 kDa dimeric multi-domain protein CheA from Escherichia coli by expressed protein ligation and protein trans-splicing2012

    • Author(s)
      Minato Y, Ueda T, Machiyama A, Shimada l, Iwai H
    • Journal Title

      Journal of Biomolecular NMR

      Volume: 53 Issue: 3 Pages: 191-207

    • DOI

      10.1007/s10858-012-9628-3

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] NMR study of ligand release from asialoglycoprotein receptor under solution conditions in early endosomes2012

    • Author(s)
      Onizuka T, Shimizu H, Moriwaki Y, Nakano T, Kanai S, Shimada I, Takahashi H.
    • Journal Title

      FEBS J

      Volume: 279 Issue: 15 Pages: 2645-2656

    • DOI

      10.1111/j.1742-4658.2012.08643.x

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Structural basis for the Golgi association by the pleckstrin homology domain of the ceramide trafficking protein (CERT)2012

    • Author(s)
      Sugiki T, Takeuchi K, Yamaji T, Takano T, Tokunaga Y, Kumagai K, Hanada K, Takahashi H, Shimada I.
    • Journal Title

      J Biol Chem

      Volume: 287 Pages: 33706-33718

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Structural Basis of Efficient Electron Transport between Photosyn thetic Membrane Proteins and Plastocyanin in Spinach Revealed using Nuclear Magnetic Resonance2012

    • Author(s)
      Takumi Ueda, Naoko Nomoto, Masamichi Koga, Hiroki Ogasa, Yuuta Ogawa, Masahiko Matsumoto, Pavlos Stampoulis, Koji Sode, Hiroaki Terasawa and Ichio Shimada
    • Journal Title

      Plant Cell

      Volume: 24 Issue: 10 Pages: 4173-4186

    • DOI

      10.1105/tpc.112.102517

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Functional dynamics of proteins revealed by solution NMR2012

    • Author(s)
      Osawa M, Takeuchi K, Ueda T, Nishida N, Shimada I.
    • Journal Title

      Curr Opin Struct Biol

      Volume: 22 Issue: 5 Pages: 660-669

    • DOI

      10.1016/j.sbi.2012.08.007

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Backbone resonance assignments for G protein α(i3) subunit in the GTP-bound state2012

    • Author(s)
      Mase Y, Yokogawa M, Osawa M, Shimada I.
    • Journal Title

      Biomol NMR Assign

      Volume: 6 Issue: 2 Pages: 217-220

    • DOI

      10.1007/s12104-012-9361-6

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Spatial distribution of cytoplasmic domains of the Mg(2+)-transporter MgtE, in a solution lacking Mg(2+), revealed by paramagnetic relaxation enhancement2012

    • Author(s)
      Imai S, Maruyama T, Osawa M, Hattori M, Ishitani R, Nureki O, Shimada I.
    • Journal Title

      Biochim Biophys Acta

      Volume: 1824 Issue: 10 Pages: 1129-1135

    • DOI

      10.1016/j.bbapap.2012.06.008

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Biological role of the two overlapping poly(A)-binding protein interacting motifs 2 (PAM2) of eukaryotic releasing factor eRF3 in mRNA decay.2012

    • Author(s)
      Osawa M, Hosoda N, Nakanishi T, Uchida N, Kimura T, Imai S, Machiyama A, Katada T, Hoshino S, Shimada I.
    • Journal Title

      RNA

      Volume: 18 Issue: 11 Pages: 1957-1967

    • DOI

      10.1261/rna.035311.112

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Functional equilibrium of the KcsA structure revealed by NMR2012

    • Author(s)
      Imai S, Osawa M, Mita K, Toyonaga S, Machiyama A, Ueda T, Takeuchi K, Oiki S, Shimada I.
    • Journal Title

      J Biol Chem

      Volume: 287 Issue: 47 Pages: 39634-39641

    • DOI

      10.1074/jbc.m112.401265

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] An NMR method to study protein-protein interaction2012

    • Author(s)
      Noritaka Nishida, Ichio Shimada
    • Journal Title

      Methods Mol.Biol.

      Volume: 757 Pages: 129-37

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Isotopic labeling of heterologous proteins in the yeast Pichia pastoris and Kluyveromyces lactis2012

    • Author(s)
      Toshihiko Sugiki, Osamu Ichikawa, Mayumi Miyazawa, -Onami, Ichio Shimada, Hideo Takahashi
    • Journal Title

      Methods Mol.Biol.(2012)831,19-36

      Volume: 831 Pages: 19-36

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] CD44の準安定なヒアルロン酸認識機構と細胞ローリング2011

    • Author(s)
      西田紀貴,嶋田一夫
    • Journal Title

      生化学

      Volume: 83(10) Pages: 893-901

    • NAID

      10029850105

    • URL

      http://www.jbsoc.or.jp/seika/wp-content/uploads/2013/05/83-10-02.pdf

    • Related Report
      2013 Final Research Report
  • [Journal Article] 共有結合を用いた平衡シフトによる過渡的タンパク質複合体からの構造情報の取得2011

    • Author(s)
      神田大輔,齊藤貴士
    • Journal Title

      生化学

      Volume: 83(10) Pages: 902-911

    • NAID

      10029850124

    • URL

      http://www.jbsoc.or.jp/seika/wp-content/uploads/2013/05/83-10-03.pdf

    • Related Report
      2013 Final Research Report
  • [Journal Article] 細胞膜上におけるトロンボポエチン受容体の一分子ダイナミクス2011

    • Author(s)
      坂本明彦、加藤尚志、船津高志
    • Journal Title

      生化学

      Volume: 83(10) Pages: 912-919

    • NAID

      10029850156

    • URL

      http://www.jbsoc.or.jp/seika/wp-content/uploads/2013/05/83-10-04.pdf

    • Related Report
      2013 Final Research Report
  • [Journal Article] 生細胞でのタンパク質選択的なケミカルラベリングの新手法2011

    • Author(s)
      松尾和哉,浜地格
    • Journal Title

      生化学

      Volume: 83(10) Pages: 920-929

    • NAID

      10029850190

    • URL

      http://www.jbsoc.or.jp/seika/wp-content/uploads/2013/05/83-10-05.pdf

    • Related Report
      2013 Final Research Report
  • [Journal Article] ケモカインによる白血球,癌細胞の生体内移動調節とケモカイン共働作用の関与2011

    • Author(s)
      早坂晴子,岡田麻里,白忠彬,黒田康嵩,吉田淳一,宮坂昌之
    • Journal Title

      生化学

      Volume: 83(10) Pages: 920-929

    • NAID

      10029850204

    • URL

      http://www.jbsoc.or.jp/seika/wp-content/uploads/2013/05/83-10-06.pdf

    • Related Report
      2013 Final Research Report
  • [Journal Article] Rapid Identification of Protein-Protein Interfaces and Construction of Complex Model Based on Multiple Unassigned Signals By Using Time-sharing NMR Measurement2011

    • Author(s)
      Yuya Kodama, Michael L.Reese, Nobuhisa Shimba, Volker Dotsch, Ei-ichiro Suzuki, Ichio Shimada, Hideo Takahashi
    • Journal Title

      J.Struct.Biol.

      Volume: 174 Pages: 434-42

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Affinity transfer to human protein by CDR3 grafting of camelid VHH2011

    • Author(s)
      Hidetoshi Inoue, Akiko IIhara, Hideo Takahashi, Ichio Shimada, Isao Ishida, Yoshitake Maeda
    • Journal Title

      Protein Sci.

      Volume: 20 Pages: 1971-81

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Protein-ligand docking guided by ligand pharmacophore-mapping experiment by NMR2011

    • Author(s)
      Yoshifumi Fukunishi, Yumiko Mizukoshi, Koh Takeuchi, Ichio Shimada, Hideo Takahashi, Haruki Nakamura
    • Journal Title

      J.Mol.Graph.Model.

      Volume: 31 Pages: 20-7

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] An Accurate Pharmacophore Mapping Method by NMR2011

    • Author(s)
      Yumiko Mizukoshi, Aya Abe, Takeshi Takizawa, Hiroyuki Hanzawa, Yoshifumi Fukunishi, Ichio Shimada, Hideo Takahashi
    • Journal Title

      Angew.Chem.In Ed Engl.(2011)

      Volume: (in press)

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Structure determination of a protein assembly by amino acid selective cross-saturation2011

    • Author(s)
      Eiji Kanamori, Shunsuke Igarashi, Masanori Osawa, Yoshifumi Fukunishi, Ichio Shimada, Haruki Nakamura
    • Journal Title

      Proteins

      Volume: 79 Pages: 179-190

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] HNCA-TOCSY-CANH experiments with alternate 13C-12C labeling : a set of 3D experiment with unique supra-sequential information for mainchain resonance assignment2011

    • Author(s)
      Koh Takeuchi, Maayan Gal, Hideo Takahashi, Ichio Shimada, Gerhard Wagner
    • Journal Title

      J.Biomol.NMR

      Volume: 49 Pages: 17-26

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Production of isotopically labeled heterologous proteins in non-E.coli prokaryotic and eukaryotic cells2010

    • Author(s)
      Hideo Takahashi, Ichio Shimada
    • Journal Title

      J.Biomol.NMR

      Volume: 46 Pages: 3-10

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Real-time assay method of lipid extraction activity2010

    • Author(s)
      Toshihiko Sugiki, Hideo Takahashi, Michiko Nagasu, Kentaro Hanada, Ichio Shimada
    • Journal Title

      Anal.Biochem.

      Volume: 399 Pages: 162-167

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Structural Basis for Platelet Anti-aggregation by AT1-Receptor Antagonist Losartan via Glycoprotein VI2010

    • Author(s)
      Katsuki Ono, Hiroshi Ueda, Yoshitaka Yoshizawa, Daisuke Akazawa, Ryuji Tanimura, Ichio Shimada, Hideo Takahashi
    • Journal Title

      J.Med.Chem.

      Volume: 53 Pages: 1917-1922

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Direct determination of the insulin-insulin receptor interface using transferred cross-saturation experiments2010

    • Author(s)
      Takefumi Nakamura, Hideo Takahashi, Mitsuo Takahashi, Nobuhisa Shimba, Ei-ichiro Suzuki, Ichio Shimada
    • Journal Title

      J.Med.Chem.

      Volume: 53 Pages: 2087-2093

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Structural basis underlying the dual gate properties of KcsA2010

    • Author(s)
      Shunsuke Imai, Masanori Osawa, Koh Takeuchi, Ichio Shimada
    • Journal Title

      Proc.Natl.Acad.Sci.USA.

      Volume: 107 Pages: 6216-6221

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Two-state conformational equilibrium of the hyaluronan-binding domain regulates adhesiveness of CD44 under flow condition2010

    • Author(s)
      Shinji Ogino, Noritaka Nishida, Ryo Umemoto, Miho Suzuki, Mitsuhiro Takeda, Hiroaki Terasawa, Joji Kitayama, Masanori Matsumoto, Haruko Hayasaka, Masayuki Miyasaka, Ichio Shimada
    • Journal Title

      Structure

      Volume: 18 Pages: 649-656

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Precise structural determination of weakly binding peptides by utilizing dihedral angle constraints2010

    • Author(s)
      Yumiko Mizukoshi, Michiko Nagasu, Ichio Shimada, Hideo Takahashi
    • Journal Title

      J.Biomol.NMR

      Volume: 46 Pages: 299-305

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] NMR analyses of the interaction between CCR5 and its ligand using functional reconstitution of CCR5 in lipid bilayers2010

    • Author(s)
      Chie Yoshiura, Yutaka Kofuku, Takumi Ueda, Yoko Mase, Mariko Yokogawa, Masanori Osawa, Yuya Terashima, Kouji Matsushima, Ichio Shimada
    • Journal Title

      J.Am.Chem.Soc.

      Volume: 132 Pages: 6768-6777

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Theoretical analyses of the transferred cross-saturation method2010

    • Author(s)
      Masahiko Matsumoto, Takumi Ueda, Ichio Shimada
    • Journal Title

      J.Magn.Reson.

      Volume: 205 Pages: 114-124

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Backbone resonance assignments for the ligand binding subunit of the histidine permease complex (HisJ) from Escherichia coli, under histidine-bound and unbound states.2010

    • Author(s)
      Igarashi S, Osawa M, Ozawa S, Shimada I.
    • Journal Title

      Biomol NMR Assign.

      Volume: 4 Pages: 7-20

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] NMR structure of the calponin homology domain of human IQGAP1 and its implications for the actin recognition mode2010

    • Author(s)
      Ryo Umemotoa, Noritaka Nishida, Shinji Oginoa, Ichio Shimada
    • Journal Title

      J.Biomol.NMR

      Volume: 48 Pages: 59-64

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Quantitative characterization of the Tob interactions provides the thermodynamic basis on the translation termination-coupled deadenylase regulation2010

    • Author(s)
      Lin Ruan, Masanori Osawa, Nao Hosoda, Shunsuke Imai, Asako Machiyama, Toshiaki Katada, Shin-ichi Hoshino, Ichio Shimada
    • Journal Title

      J.Biol.Chem.

      Volume: 285 Pages: 27624-27631

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Structural investigation of the interaction between the periplasmic chaperone LolA and the outer membrane receptor LolB using NMR2009

    • Author(s)
      Shingo Nakada
    • Journal Title

      J.Biol.Chem. 284

      Pages: 24634-24643

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Observation of NMR signals from proteins introduced into living mammalian cells by reversible membrane permeabilization using a pore-forming toxin, Streptolysin O2009

    • Author(s)
      Shinji Ogino
    • Journal Title

      J.Am.Chem.Soc. 131

      Pages: 10834-10835

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Interaction between chemokine SDF-1 and its GPCR CXCR4 investigated by NMR2009

    • Author(s)
      Yutaka Kofuku
    • Journal Title

      J.Biol.Chem. 284

      Pages: 35240-35250

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Presentation] NMR studies on drug target proteins2015

    • Author(s)
      Ichio Shimada
    • Organizer
      The 4th International Symposium on Drug Discovery and Design by NMR
    • Place of Presentation
      神奈川県横浜市
    • Year and Date
      2015-02-05
    • Related Report
      2014 Annual Research Report
  • [Presentation] Functional dynamics of GPCR in micelles and lipid bilayers2015

    • Author(s)
      Ichio Shimada
    • Organizer
      Advanced Stable Isotopic Labelling for Integrated Structural Biology AILM 2015
    • Place of Presentation
      Grenoble, France
    • Year and Date
      2015-02-03
    • Related Report
      2014 Annual Research Report
    • Invited
  • [Presentation] Functional Equilibrium of Membrane Proteins by NMR2014

    • Author(s)
      Ichio Shimada
    • Organizer
      Internatinal Connfrence of Magnetic Resonance in Biological Systems
    • Place of Presentation
      Dallas, USA
    • Year and Date
      2014-08-26
    • Related Report
      2014 Annual Research Report
    • Invited
  • [Presentation] Functional Equilibrium of Membrane Proteins2014

    • Author(s)
      Ichio Shimada
    • Organizer
      the EMBO Workshop on “Magnetic Resonance for Cellular Structural Biology”
    • Place of Presentation
      Principina Terra, Italy
    • Year and Date
      2014-06-01
    • Related Report
      2014 Annual Research Report
    • Invited
  • [Presentation] Functional Equilibrium of Membrane Proteins2014

    • Author(s)
      Ichio Shimada
    • Organizer
      The Spring International Convention of the Pharmaceutical Society of Korea
    • Place of Presentation
      Seoul, Korea
    • Year and Date
      2014-04-17
    • Related Report
      2014 Annual Research Report
    • Invited
  • [Presentation] メチル化CpG結合蛋白質MBD4による緩い基質DNA認識2013

    • Author(s)
      有吉眞理子,大谷淳二,白川昌宏
    • Organizer
      第51回日本生物物理学会年会ワークショップ「過渡的複合体が関わる生命現象の統合的理解」
    • Place of Presentation
      京都府京都市
    • Year and Date
      2013-10-29
    • Related Report
      2013 Final Research Report
  • [Presentation] タンパク質結晶中に意図的に創り出した空間を使って,タンパク質に結合した状態のリガンドの大振幅運動を解析する2013

    • Author(s)
      神田大輔
    • Organizer
      第51回日本生物物理学会年会ワークショップ「過渡的複合体が関わる生命現象の統合的理解」
    • Place of Presentation
      京都府京都市
    • Year and Date
      2013-10-29
    • Related Report
      2013 Final Research Report
  • [Presentation] ゲル包埋型バイオリアクターを用いた生細胞内蛋白質間相互作用のNMR観測2013

    • Author(s)
      西田紀貴,嶋田一夫
    • Organizer
      第51回日本生物物理学会年会ワークショップ「過渡的複合体が関わる生命現象の統合的理解」
    • Place of Presentation
      京都府京都市
    • Year and Date
      2013-10-29
    • Related Report
      2013 Final Research Report
  • [Presentation] タンパク質解析のための生細胞でのケミカルラベリンク2013

    • Author(s)
      浜地格
    • Organizer
      第51回日本生物物理学会年会ワークショップ「過渡的複合体が関わる生命現象の統合的理解」
    • Place of Presentation
      京都府京都市
    • Year and Date
      2013-10-29
    • Related Report
      2013 Final Research Report
  • [Presentation] ケモカイン受容体多量体形成による細胞動態の調節2013

    • Author(s)
      早坂晴子,小林大地,宮坂昌之
    • Organizer
      第51回日本生物物理学会年会ワークショップ「過渡的複合体が関わる生命現象の統合的理解」
    • Place of Presentation
      京都府京都市
    • Year and Date
      2013-10-29
    • Related Report
      2013 Final Research Report
  • [Presentation] 一回膜貫通型サイトカイン受容体Mpl二量体化の一分子蛍光解析2013

    • Author(s)
      坂本明彦,加藤尚志,船津高志
    • Organizer
      第51回日本生物物理学会年会ワークショップ「過渡的複合体が関わる生命現象の統合的理解」
    • Place of Presentation
      京都府京都市
    • Year and Date
      2013-10-29
    • Related Report
      2013 Final Research Report
  • [Presentation] NMRによる膜タンパク質の機能解明2013

    • Author(s)
      嶋田一夫
    • Organizer
      よこはまNMR構造生物学研究会
    • Place of Presentation
      神奈川県横浜市
    • Year and Date
      2013-03-22
    • Related Report
      2012 Annual Research Report
  • [Presentation] Functional Equilibrium of Membrane Proteins2013

    • Author(s)
      嶋田一夫
    • Organizer
      Frontiers of NMR in Biology, Keystone Symposia,
    • Place of Presentation
      Snowbird, Utah, USA
    • Year and Date
      2013-01-17
    • Related Report
      2012 Annual Research Report
  • [Presentation] Functional Dynamics of Membrane Proteins by NMR2012

    • Author(s)
      嶋田一夫
    • Organizer
      第85回生化学会年会
    • Place of Presentation
      福岡県福岡市
    • Year and Date
      2012-12-11
    • Related Report
      2012 Annual Research Report
    • Invited
  • [Presentation] NMRによる膜タンパク質の機能解明2012

    • Author(s)
      嶋田一夫
    • Organizer
      第34回生体膜と薬物の相互作用シンポジウム
    • Place of Presentation
      京都府京都市
    • Year and Date
      2012-11-15
    • Related Report
      2012 Annual Research Report
    • Invited
  • [Presentation] Functional Dynamics of Membrane Proteins2012

    • Author(s)
      嶋田一夫
    • Organizer
      The 3rd International Symposium on Drug Discovery and Design by NM
    • Place of Presentation
      神奈川県横浜市
    • Year and Date
      2012-10-11
    • Related Report
      2012 Annual Research Report
    • Invited
  • [Presentation] Functional Dynamics of Membrane Proteins2012

    • Author(s)
      嶋田一夫
    • Organizer
      ICMRBS
    • Place of Presentation
      リヨン、フランス
    • Year and Date
      2012-08-21
    • Related Report
      2012 Annual Research Report
    • Invited
  • [Presentation] 膜タンパク質を対象としたNMR創薬基盤技術2012

    • Author(s)
      嶋田一夫
    • Organizer
      第25回バイオメディカル分析科学シンポジウム
    • Place of Presentation
      東京都港区
    • Year and Date
      2012-08-09
    • Related Report
      2012 Annual Research Report
    • Invited
  • [Presentation] NMRによる膜タンパク質の機能解明2012

    • Author(s)
      嶋田一夫
    • Organizer
      第13回若手NMR研究会
    • Place of Presentation
      北海道、支笏湖
    • Year and Date
      2012-07-20
    • Related Report
      2012 Annual Research Report
    • Invited
  • [Presentation] NMRを用いた膜タンパク質の機能解明2012

    • Author(s)
      嶋田一夫
    • Organizer
      第11回日本蛋白質科学会
    • Place of Presentation
      愛知県名古屋市
    • Year and Date
      2012-06-22
    • Related Report
      2012 Annual Research Report
    • Invited
  • [Presentation] Dynamical aspects of membrane proteins2012

    • Author(s)
      嶋田一夫
    • Organizer
      INPEC2012
    • Place of Presentation
      台北、台湾
    • Year and Date
      2012-04-06
    • Related Report
      2012 Annual Research Report
    • Invited
  • [Presentation] A novel in-cell NMR technique to determine the binding interface of functional protein complexes in mammalian cells2012

    • Author(s)
      久保智史、荻野新治、宇田川侑子、宝田理、西田紀貴、嶋田一夫
    • Organizer
      第132回日本薬学会年会日本薬学会
    • Place of Presentation
      北海道大学(札幌)
    • Year and Date
      2012-03-30
    • Related Report
      2011 Annual Research Report
  • [Presentation] The effect of tensile force on CD44 mediated cell rolling2012

    • Author(s)
      鈴木隆、鈴木美穂、西田紀貴、嶋田一夫
    • Organizer
      第132回日本薬学会年会日本薬学会
    • Place of Presentation
      北海道大学(札幌)
    • Year and Date
      2012-03-30
    • Related Report
      2011 Annual Research Report
  • [Presentation] Elucidation of regulatory mechanism for arrestin activation by G-protein coupled receptor2012

    • Author(s)
      白石勇太郎, 幸福裕, 奥出順也, 吉浦知絵, 阿内康平, 上田卓見, 嶋田一夫
    • Organizer
      第132回日本薬学会年会日本薬学会
    • Place of Presentation
      北海道大学(札幌)(ポスター)
    • Year and Date
      2012-03-30
    • Related Report
      2011 Annual Research Report
  • [Presentation] Elucidation of the mechanism of analgesic tolerance by chronic administration of morphine2012

    • Author(s)
      奥出順也, 吉浦知絵, 白石勇太郎, 幸福裕, 上田卓見, 嶋田一夫
    • Organizer
      第132回日本薬学会年会日本薬学会
    • Place of Presentation
      北海道大学(札幌)
    • Year and Date
      2012-03-30
    • Related Report
      2011 Annual Research Report
  • [Presentation] Dynamical Aspects of Membrane Proteins2011

    • Author(s)
      Ichio Shimada
    • Organizer
      MBSJ2011
    • Place of Presentation
      パシフィコ横浜(横浜)(招待講演)
    • Year and Date
      2011-12-14
    • Related Report
      2011 Annual Research Report
  • [Presentation] Structural Mechanism for the Affinity-Regulation of Cytoplasmic Dynein2011

    • Author(s)
      宝田理, 西田紀貴、吉川雅英、嶋田一夫
    • Organizer
      第34回日本分子生物学会年会日本分子生物学会
    • Place of Presentation
      パシフィコ横浜(横浜)
    • Year and Date
      2011-12-13
    • Related Report
      2011 Annual Research Report
  • [Presentation] Structural investigation of voltage-sensing mechanism of voltage-dependent K+ channels2011

    • Author(s)
      原田瞳, 大澤匡範, 小澤新一郎, 木村友美, 野崎智裕, 嶋田一夫
    • Organizer
      第34回日本分子生物学会年会日本分子生物学会
    • Place of Presentation
      パシフィコ横浜(横浜)(ポスター)
    • Year and Date
      2011-12-13
    • Related Report
      2011 Annual Research Report
  • [Presentation] Structural basis for the inhibition of voltage-dependent potassium (Kv) channels by gating modifier toxins2011

    • Author(s)
      小澤新一郎、大澤匡範、木村友美、原田瞳、野崎智裕、嶋田一夫
    • Organizer
      第34回日本分子生物学会年会日本分子生物学会
    • Place of Presentation
      パシフィコ横浜(横浜)(ポスター)
    • Year and Date
      2011-12-13
    • Related Report
      2011 Annual Research Report
  • [Presentation] Dynamical Aspects of Membrane Proteins2011

    • Author(s)
      Ichio Shimada
    • Organizer
      AIMECS11
    • Place of Presentation
      京王プラザホテル(東京)(招待講演)
    • Year and Date
      2011-12-02
    • Related Report
      2011 Annual Research Report
  • [Presentation] Dynamical Aspects of Membrane Proteins2011

    • Author(s)
      Ichio Shimada
    • Organizer
      The 4th Asia-Pacific NMR Symposium
    • Place of Presentation
      Central Garden Beijing Hotel(北京、中国)(招待講演)
    • Year and Date
      2011-10-17
    • Related Report
      2011 Annual Research Report
  • [Presentation] Functional Analyses of Membrane Proteins by NMR2011

    • Author(s)
      Ichio Shimada
    • Organizer
      The 9th International Symposium for Future Drug Discovery and Medical Care
    • Place of Presentation
      北海道大学(札幌)(招待講演)
    • Year and Date
      2011-09-29
    • Related Report
      2011 Annual Research Report
  • [Presentation] 1分子イメージングによってわかるタンパク質の働き2011

    • Author(s)
      船津高志
    • Organizer
      日本バイオイメージング学会第20回学術集会公開講座
    • Place of Presentation
      千歳市民文化センター、千歳市、北海道
    • Year and Date
      2011-08-31
    • Related Report
      2013 Final Research Report
  • [Presentation] NMRによる GPCR・リガンド相互作用解析2011

    • Author(s)
      嶋田一夫
    • Organizer
      新学術領域研究「過渡的複合体」公開シンポジウム
    • Place of Presentation
      東京大学薬学部東京
    • Year and Date
      2011-07-21
    • Related Report
      2013 Final Research Report
  • [Presentation] 共有結合を用いた平衡シフトによる過渡的タンパク質複合体の安定化とその応用2011

    • Author(s)
      神田大輔
    • Organizer
      新学術領域研究「過渡的複合体」公開シンポジウム
    • Place of Presentation
      東京大学薬学部東京
    • Year and Date
      2011-07-21
    • Related Report
      2013 Final Research Report
  • [Presentation] 細胞膜上におけるトロンボポエチン受容体の一分子ダイナミクス2011

    • Author(s)
      船津高志
    • Organizer
      新学術領域研究「過渡的複合体」公開シンポジウム
    • Place of Presentation
      東京大学薬学部東京
    • Year and Date
      2011-07-21
    • Related Report
      2013 Final Research Report
  • [Presentation] 生細胞での蛋白質の選択的ケミカルラベル化と機能化2011

    • Author(s)
      浜地格
    • Organizer
      新学術領域研究「過渡的複合体」公開シンポジウム
    • Place of Presentation
      東京大学薬学部東京
    • Year and Date
      2011-07-21
    • Related Report
      2013 Final Research Report
  • [Presentation] 磁気共鳴を使った生細胞における分子動態の計測手法の開発2011

    • Author(s)
      白川昌宏
    • Organizer
      新学術領域研究「過渡的複合体」公開シンポジウム
    • Place of Presentation
      東京大学薬学部東京
    • Year and Date
      2011-07-21
    • Related Report
      2013 Final Research Report
  • [Presentation] 白血球、癌細胞の生体内動態調節におけるケモカイン共働作用2011

    • Author(s)
      早坂晴子
    • Organizer
      新学術領域研究「過渡的複合体」公開シンポジウム
    • Place of Presentation
      東京大学薬学部東京
    • Year and Date
      2011-07-21
    • Related Report
      2013 Final Research Report
  • [Presentation] Molecular interaction of membrane proteins by NMR2011

    • Author(s)
      Ichio Shimada
    • Organizer
      Functional Proteomics & KIST Symposium
    • Place of Presentation
      Korea Institute of Science and Technology, International Cooperation Bldg(ソウル、韓国)(招待講演)
    • Year and Date
      2011-02-02
    • Related Report
      2011 Annual Research Report
  • [Presentation] NMR法によるactinとactin結合タンパク質との相互作用解析法の開発2010

    • Author(s)
      黄淑嫻、梅本良、上田太郎、西田紀貴、嶋田一夫
    • Organizer
      第33回日本分子生物学会年会 第83回日本生化学会大会合同大会
    • Place of Presentation
      神戸ポートアイランド,兵庫県
    • Year and Date
      2010-12-08
    • Related Report
      2010 Annual Research Report
  • [Presentation] 高分子量蛋白質の構造解析に適した安定同位体ラベル法および測定法の開発2010

    • Author(s)
      竹内恒、高橋栄夫、嶋田一夫、Gerhard Wagner
    • Organizer
      第49回NMR討論会
    • Place of Presentation
      船堀タワーホール,東京都
    • Year and Date
      2010-11-15
    • Related Report
      2010 Annual Research Report
  • [Presentation] Dynamical aspects of membrane proteins2010

    • Author(s)
      嶋田一夫
    • Organizer
      Max Planck Institute seminar
    • Place of Presentation
      Gottingen, Germany
    • Year and Date
      2010-10-21
    • Related Report
      2010 Annual Research Report
  • [Presentation] Dynamical aspects of membrane proteins2010

    • Author(s)
      嶋田一夫
    • Organizer
      Technische Universitat Munchen/Helmholtz Zentrum Munchen seminar
    • Place of Presentation
      Munchen, Germany
    • Year and Date
      2010-10-20
    • Related Report
      2010 Annual Research Report
  • [Presentation] Dynamical aspects of membrane proteins by NMR2010

    • Author(s)
      嶋田一夫
    • Organizer
      The International Network of Protein Engineering Centres (INPEC) 2010
    • Place of Presentation
      Uppsala, Sweden
    • Year and Date
      2010-10-08
    • Related Report
      2010 Annual Research Report
  • [Presentation] The 2nd International Symposium on Drug Discovery and Design by NMR2010

    • Author(s)
      嶋田一夫
    • Organizer
      Functional analyses of membrane proteins by NMR
    • Place of Presentation
      横浜市立大学,神奈川県
    • Year and Date
      2010-09-30
    • Related Report
      2010 Annual Research Report
  • [Presentation] NMRを用いた膜タンパク質の機能解明2010

    • Author(s)
      嶋田一夫
    • Organizer
      日本分光学会NMR分光部会シンポジウム
    • Place of Presentation
      東京大学,東京都
    • Year and Date
      2010-09-08
    • Related Report
      2010 Annual Research Report
  • [Presentation] Dynamical aspects of membrane proteins2010

    • Author(s)
      嶋田一夫
    • Organizer
      Frankfurt University seminar
    • Place of Presentation
      Frankfurt, Germany
    • Year and Date
      2010-09-06
    • Related Report
      2010 Annual Research Report
  • [Presentation] Dynamical aspects of membrane proteins2010

    • Author(s)
      嶋田一夫
    • Organizer
      International Conference on Magnetic Resonance in Biological Systems
    • Place of Presentation
      Cairns, Australia
    • Year and Date
      2010-08-23
    • Related Report
      2010 Annual Research Report
  • [Presentation] NMRによるケモカイン受容体・ケモカイン相互作用解析2010

    • Author(s)
      嶋田一夫
    • Organizer
      第34回阿蘇シンポジウム
    • Place of Presentation
      阿蘇リゾートグランヴィリオホテル,熊本県
    • Year and Date
      2010-07-30
    • Related Report
      2010 Annual Research Report
  • [Presentation] -超高磁場が拓く生体系NMR:最新技術と応用-膜タンパク質のダイナミックスと機能2010

    • Author(s)
      嶋田一夫
    • Organizer
      大阪大学蛋白質研究所セミナー
    • Place of Presentation
      大阪大学,大阪府
    • Year and Date
      2010-07-29
    • Related Report
      2010 Annual Research Report
  • [Presentation] NMRによる膜タンパク質の機能解析2010

    • Author(s)
      嶋田一夫
    • Organizer
      日本学術振興会、回折構造生物学第169委員会、第32回研究会
    • Place of Presentation
      ゆうぽうと,東京都
    • Year and Date
      2010-07-20
    • Related Report
      2010 Annual Research Report
  • [Presentation] Structural bases of the interactions between chemokines and their G-protein-coupled receptors2010

    • Author(s)
      嶋田一夫
    • Organizer
      Symposium on Structure and Folding of Disease Related Proteins
    • Place of Presentation
      Seoul National University, Korea
    • Year and Date
      2010-07-10
    • Related Report
      2010 Annual Research Report
  • [Presentation] Structural bases of the interactions between chemokines and their G-protein-coupled receptors2010

    • Author(s)
      嶋田一夫
    • Organizer
      EUROMAR/ISMAR
    • Place of Presentation
      Florence, Italy
    • Year and Date
      2010-07-06
    • Related Report
      2010 Annual Research Report
  • [Presentation] 過渡的複合体が関わる生命現象の統合的理解2010

    • Author(s)
      嶋田一夫
    • Organizer
      第10回日本蛋白質科学会年会ワークショップ「過渡的複合体の視点から生命現象を捉えなおす」
    • Place of Presentation
      北海道札幌市
    • Year and Date
      2010-06-16
    • Related Report
      2013 Final Research Report
  • [Presentation] 準安定な分子複合体から構造情報を得るための新戦略2010

    • Author(s)
      神田大輔
    • Organizer
      第10回日本蛋白質科学会年会ワークショップ「過渡的複合体の視点から生命現象を捉えなおす」
    • Place of Presentation
      北海道札幌市
    • Year and Date
      2010-06-16
    • Related Report
      2013 Final Research Report
  • [Presentation] トロンボポエチンシグナルの上流部は脂質ラフトによって制御されている2010

    • Author(s)
      坂本明彦、加藤尚志、船津高志
    • Organizer
      第10回日本蛋白質科学会年会ワークショップ「過渡的複合体の視点から生命現象を捉えなおす」
    • Place of Presentation
      北海道札幌市
    • Year and Date
      2010-06-16
    • Related Report
      2013 Final Research Report
  • [Presentation] 細胞での蛋白質選択的ケミカルラベリングの新手法2010

    • Author(s)
      浜地格
    • Organizer
      第10回日本蛋白質科学会年会ワークショップ「過渡的複合体の視点から生命現象を捉えなおす」
    • Place of Presentation
      北海道札幌市
    • Year and Date
      2010-06-16
    • Related Report
      2013 Final Research Report
  • [Presentation] ケモカインレセプターの準安定状態と細胞動態2010

    • Author(s)
      早坂晴子、吉村洋美、白忠彬、宮坂昌之
    • Organizer
      第10回日本蛋白質科学会年会ワークショップ「過渡的複合体の視点から生命現象を捉えなおす」
    • Place of Presentation
      北海道札幌市
    • Year and Date
      2010-06-16
    • Related Report
      2013 Final Research Report
  • [Presentation] In-cell NMR法による細胞内環境下の蛋白質の構造と機能の解析2010

    • Author(s)
      白川昌宏
    • Organizer
      第10回日本蛋白質科学会年会ワークショップ「過渡的複合体の視点から生命現象を捉えなおす」
    • Place of Presentation
      北海道札幌市
    • Year and Date
      2010-06-16
    • Related Report
      2013 Final Research Report
  • [Presentation] 過渡的複合体が関わる生命現象の統合的理解2010

    • Author(s)
      嶋田一夫
    • Organizer
      第10回日本蛋白質科学会年会
    • Place of Presentation
      札幌コンベンションセンター,北海道
    • Year and Date
      2010-06-16
    • Related Report
      2010 Annual Research Report
  • [Presentation] Functional analyses of membrane proteins by NMR2010

    • Author(s)
      嶋田一夫
    • Organizer
      COLD SPRING HARBOR ASIA CONFERENCES
    • Place of Presentation
      Suzhou, China
    • Year and Date
      2010-05-13
    • Related Report
      2010 Annual Research Report
  • [Presentation] Protein recognition by NMR2009

    • Author(s)
      Ichio Shimada
    • Organizer
      International Network of Protein Engineering Conference
    • Place of Presentation
      Itamambuca, Brasil
    • Year and Date
      2009-10-26
    • Related Report
      2009 Annual Research Report
  • [Presentation] Functional Equilibrium of Membrane Proteins

    • Author(s)
      嶋田一夫
    • Organizer
      54th Experimental Nuclear Magnetic Resonance Conference
    • Place of Presentation
      Asilomar, California, USA
    • Related Report
      2013 Annual Research Report
    • Invited
  • [Presentation] Functional Equilibrium of Membrane Proteins

    • Author(s)
      嶋田一夫
    • Organizer
      International Conference on Structural Genomics 2013
    • Place of Presentation
      北海道札幌市
    • Related Report
      2013 Annual Research Report
    • Invited
  • [Presentation] Functional Equilibrium of GPCR

    • Author(s)
      嶋田一夫
    • Organizer
      Symposium “Perspectives of NMR in drug discovery
    • Place of Presentation
      Novartis, Basel, Switzerland
    • Related Report
      2013 Annual Research Report
    • Invited
  • [Presentation] Functional Equilibrium of GPCR

    • Author(s)
      嶋田一夫
    • Organizer
      5th Asia-Pacific NMR Symposium in conjunction with ANZNAG2013
    • Place of Presentation
      Brisbane, Australia
    • Related Report
      2013 Annual Research Report
    • Invited
  • [Presentation] NMR を用いた高分子量タンパク質複合体の相互作用解析法の開発と応用

    • Author(s)
      嶋田一夫
    • Organizer
      第36回日本分子生物学会年会
    • Place of Presentation
      兵庫県神戸市
    • Related Report
      2013 Annual Research Report
    • Invited
  • [Book] Encyclopedia of Biophysics(GCR.Roberts (ed.))2011

    • Author(s)
      Ichio Shimada
    • Total Pages
      1
    • Publisher
      Springer-Verlag Berlin Heidelberg Ichio Shimada
    • Related Report
      2011 Annual Research Report
  • [Remarks] 過渡的複合体 領域HP

    • URL

      http://ishimada.f.u-tokyo.ac.jp/public_html/tmc/newsletter/newsletter.html

    • Related Report
      2014 Annual Research Report
  • [Remarks] 領域まとめ国際シンポジウム

    • URL

      http://www.biophys.jp/news/lib/newsshow.php/2966

    • Related Report
      2014 Annual Research Report
  • [Remarks] 過渡的複合体 HP

    • URL

      http://ishimada.f.u-tokyo.ac.jp/public_html/tmc/

    • Related Report
      2013 Final Research Report
  • [Remarks] 過渡的複合体 領域HP

    • URL

      http://ishimada.f.u-tokyo.ac.jp/public_html/tmc/

    • Related Report
      2013 Annual Research Report
  • [Remarks] 過渡的複合体 領域HP

    • URL

      http://ishimada.f.u-tokyo.ac.jp/public_html/tmc/

    • Related Report
      2012 Annual Research Report
  • [Remarks]

    • URL

      http://ishimada.f.u-tokyo.ac.jp/public_html/tmc/

    • Related Report
      2009 Annual Research Report

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Published: 2009-04-01   Modified: 2018-12-17  

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