Integrative understanding of biological processes mediated by transient macromolecul ar complexes; New technology for visualizing physiologically metastable states

• Project Area: Integrative understanding of biological processes mediated by transient macromolecular complexes; New technology for visualizing physiologically metastable states.
• Project/Area Number: 21121001
• Research Category: Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)
• Allocation Type: Single-year Grants
• Review Section: Complex systems
• Research Institution: The University of Tokyo
• Principal Investigator: SHIMADA Ichio 東京大学, 薬学研究科(研究院), 教授 (70196476)
• Co-Investigator(Kenkyū-buntansha): KOHDA Daisuke 九州大学, 生体防御医学研究所, 教授 (80186618) ; 浜地 格 京都大学, 大学院・工学研究科, 教授 (90202259) ; 白川 昌宏 京都大学, 大学院・工学研究科, 教授 (00202119) ; 森川 耿右 大阪大学, タンパク質研究所, 特任研究員(客員教授) (80012665) ; 早坂 晴子 大阪大学, 大学院・医学系研究科, 助教 (70379246)
• Co-Investigator(Renkei-kenkyūsha): FUNATSU Takashi 東京大学, 大学院薬学系研究科, 教授 (00190124) ; HAMACHI Itaru 京都大学, 工学研究科, 教授 (90202259) ; SHIRAKAWA Masahiro 京都大学, 工学研究科, 教授 (00202119) ; HAYASAKA Haruko 大阪大学, 医学系研究科, 助教 (70379246) ; AKUTSU Hideo 大阪大学, 蛋白質研究所, 客員教授 (60029965) ; INAGAKI Fuyuhiko 北海道大学, 先端生命科学研究科, 教授 (70011757) ; MIYASAKA Masayuki 大阪大学, 医学系研究科, 教授 (50064613) ; NISHIMURA Yoshifumi 横浜市立大学, 国際総合科学部, 教授 (70107390) ; MORIKAWA Kosuke 国際高等研究所, チーフリサーチフェロー (80012665)
• Project Period (FY): 2009-07-23 – 2014-03-31
• Project Status: Completed (Fiscal Year 2014)
• Keywords: 領域とりまとめ / 構造生物学 / 核磁気共鳴法 / X線結晶構造解析 / 一分子計測学 / ケミカルバイオロジー / Ｘ線結晶構造解析 / ケミカル・バイオロジ / ケミカルバイオロジ

Outline of Annual Research Achievements

領域まとめのシンポジウムを主催した。平成27年2月4日と5日の2日間にわたって、理化学研究所横浜事業所交流棟ホールにて開催した。
海外からの招待講演者として、Peter Wright 博士(Scripps, USA)、Angela M. Gronenborn博士 (Univ. of Pittsburgh, USA)、Tai-huang Huang博士 (Academia Sinica, Taiwan)、
Michael Sattler 博士(Technische Universitat Munchen, Germany)、Wolfgang Jahnke博士 (Novartis, Switzerland)、Mitsuhiko Ikura 博士(Univ. Toronto, Canada)、Christian Griesinger博士 (MPI, Germany)、Juli Feigon博士 (UCLA, USA)、 Bong-Jin Lee博士 (Seoul National Univ. Korea)、Philipp Selenko博士 (Leibniz Institute, Germany)を招待した。
開催に際してはHPやポスターを配布するなどして広く告知を行った。また、参加者への便宜を図るため、講演スライドのハンドアウトを参加者へ配布した。
また計画班から嶋田と白川が、公募班員の片平と児嶋がそれぞれ講演を行い、本新学術領域の成果を公表した。2日間にわたるシンポジウムを行い、134名が出席した。

Research Progress Status

26年度が最終年度であるため、記入しない。

Strategy for Future Research Activity

26年度が最終年度であるため、記入しない。

Research Products

• [Journal Article] Suppression of problematic compound oligomerization by cosolubilization of nondetergent sulfobetaines (2015)
  • Author(s): Mizukoshi Y, Takeuchi K, Arutaki M, Takizawa T, Hanzawa H, Takahashi H, Shimada I
  • Journal Title: ChemMedChem Volume: 10 Issue: 4 Pages: 736-741
  • DOI: 10.1002/cmdc.201500057
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] Development of a method for reconstruction of crowded NMR spectra from undersampled time-domain data (2014)
  • Author(s): Ueda T, Yoshiura C, Matsumoto M, Kofuku Y, Okude J, Kondo K, Shiraishi Y, Takeuchi K, Shimada I.
  • Journal Title: J Biomol NMR Volume: なし
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] Dynamic multidrug recognition by multidrug transcriptional repressor LmrR (2014)
  • Author(s): Takeuchi K, Tokunaga Y, Imai M, Takahashi H, Shimada I.
  • Journal Title: Sci Rep Volume: 4 Issue: 1 Pages: 6922-6922
  • DOI: 10.1038/srep06922
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Functional dynamics of deuterated β2 -adrenergic receptor in lipid bilayers revealed by NMR spectroscopy (2014)
  • Author(s): Kofuku Y, Ueda T, Okude J, Shiraishi Y, Kondo K, Mizumura T, Suzuki S, Shimada I
  • Journal Title: Angew Chem Int Ed Engl Volume: 53 Issue: 49 Pages: 13376-13379
  • DOI: 10.1002/anie.201406603
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Structural basis for the binding of the membrane-proximal C-terminal region of chemokine receptor CCR2 with the cytosolic regulator FROUNT (2014)
  • Author(s): Esaki K, Yoshinaga S, Tsuji T, Toda E, Terashima Y, Saitoh T, Kohda D, Kohno T, Osawa M, Ueda T, Shimada I, Matsushima K, Terasawa H
  • Journal Title: FEBS J Volume: 281 Issue: 24 Pages: 552-566
  • DOI: 10.1111/febs.13096
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] Allosteric enhancement of MAP kinase p38α's activity and substrate selectivity by docking interactions (2014)
  • Author(s): Tokunaga Y, Takeuchi K, Takahashi H, Shimada I
  • Journal Title: Nat Struct Mol Biol Volume: 21 Issue: 8 Pages: 704-711
  • DOI: 10.1038/nsmb.2861
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] Cross-saturation and transferred cross-saturation experiments (2014)
  • Author(s): Ueda T, Takeuchi K, Nishida N, Stampoulis P, Kofuku Y, Osawa M, Shimada I
  • Journal Title: Q Rev Biophys Volume: 47 Issue: 2 Pages: 143-187
  • DOI: 10.1017/s0033583514000043
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] Structure-based approach to improve a small-molecule inhibitor by the use of a competitive peptide ligand. (2014)
  • Author(s): Ono K, Takeuchi K, Ueda H, Morita Y, Tanimura R, Shimada I, Takahashi H.
  • Journal Title: Angew Chem Int Ed Engl Volume: 53 Issue: 10 Pages: 2597-2597
  • DOI: 10.1002/anie.201310749
  • Peer Reviewed
• [Journal Article] Functional dynamics of cell surface membrane proteins (2014)
  • Author(s): Nishida N, Osawa M, Takeuchi K, Imai S, Stampoulis P, Kofuku Y, Ueda T, Shimada I
  • Journal Title: J Magn Reson Volume: 241 Pages: 86-96
  • DOI: 10.1016/j.jmr.2013.11.007
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] Identification of a binding element for the cytoplasmic regulator FROUNTin the membrane-proximal C-terminal region of chemokine receptors CCR2 and CCR5. (2014)
  • Author(s): Toda E, Terashlma Y, Esakii K, Yoshinaga S, Sugihara M, Kofuku Y, Shimada I, Suwa M, Kanegasaki S, Terasawa H, Matsushima K.
  • Journal Title: Biochemical Journal Volume: Vol.457 Issue: 2 Pages: 313-322
  • DOI: 10.1042/bj20130827
  • Peer Reviewed
• [Journal Article] A Gel-Encapsulated Bioreactor System for NMR Studies of Protein-Protein Interactions in Living Mammalian Cells (2013)
  • Author(s): Satoshi Kubo, Noritaka Nishida, Yuko Udagawa, Osamu Takarada, Shinji Ogino, Ichio Shimada
  • Journal Title: Angewandte Chemie International Edition Volume: 52 Issue: 4 Pages: 1208-1211
  • DOI: 10.1002/anie.201207243
  • Peer Reviewed
• [Journal Article] Backbone resonance assignments for the cytoplasmic region of the Mg(2+) transporter MgtE in the Mg (2+)-unbound state (2013)
  • Author(s): Maruyama T, Imai S, Osawa M, Hattori M, Ishitani R, Nureki O, Shimada I.
  • Journal Title: Biomol NMR Assign Volume: 7 Issue: 1 Pages: 93-96
  • DOI: 10.1007/s12104-012-9385-y
  • Peer Reviewed
• [Journal Article] Structure of the Mouse Sex Peptide Pheromone ESP1 Reveals a Molecular Basis for Specific Binding to the Class C G-protein-coupled Vomeronasal Receptor (2013)
  • Author(s): Yoshinaga S, Sato T, Hirakane M, Esaki K, Hamaguchi T, Haga-Yamanaka S, Tsunoda M, Kimoto H, Shimada I, Touhara K, Terasawa H
  • Journal Title: The Journal of Biological Chemistry Volume: 288 Issue: 22 Pages: 16064-72
  • DOI: 10.1074/jbc.m112.436782
  • Peer Reviewed
• [Journal Article] Backbone resonance assignments for G protein α(i3) subunit in the GDP-bound state (2013)
  • Author(s): Mase Y, Yokogawa M, Osawa M, Shimada I.
  • Journal Title: Biomol NMR Assign
  • Peer Reviewed
• [Journal Article] Nuclear magnetic resonance approaches for characterizing interactions between the bacterial chaperonin GroEL and unstructured proteins. (2013)
  • Author(s): Nishida N, Yagi-Utsumi M, Motojima F, Yoshida M, Shimada I, Kato K.
  • Journal Title: J Biosci Bioeng Volume: 116 Issue: 2 Pages: 160-164
  • DOI: 10.1016/j.jbiosc.2013.02.012
  • NAID: 110009657195
  • Peer Reviewed
• [Journal Article] Backbone and side-chain (1)H, (15)N and (13)C resonance assignments of the microtubule-binding domain of yeast cytoplasmic dynein in the high and low-affinity states. (2013)
  • Author(s): Takarada O, Nishida N, Kikkawa M, Shimada I.
  • Journal Title: Biomol NMR Assign
  • Peer Reviewed
• [Journal Article] Perdeuteration and methyl-selective (1)H, (13)C-labeling by using a Kluyveromyces lactis expression system (2013)
  • Author(s): Miyazawa-Onami M, Takeuchi K, Takano T, Sugiki T, Shimada I, Takahashi H.
  • Journal Title: J Biomol NMR Volume: 57 Issue: 3 Pages: 297-304
  • DOI: 10.1007/s10858-013-9789-8
  • Peer Reviewed
• [Journal Article] Rapid identification of ligand-binding sites by using an assignment-free NMR approach (2013)
  • Author(s): Kodama Y, Takeuchi K, Shimba N, Ishikawa K, Suzuki E, Shimada I, Takahashi H.
  • Journal Title: J Med Chem Volume: 56 Issue: 22 Pages: 9342-9350
  • DOI: 10.1021/jm4014357
  • Peer Reviewed
• [Journal Article] Efficacy of the β2-adrenergic receptor is determined by conformational equilibrium in the transmembrane region (2012)
  • Author(s): Kofuku Y, Ueda T, Okude J, Shiraishi Y, Kondo K, Maeda M, Tsujishita H, Shimada I
  • Journal Title: Nat Commun. Volume: 3 Issue: 1 Pages: 1045-1045
  • DOI: 10.1038/ncomms2046
  • Peer Reviewed
• [Journal Article] An NMR method to study protein-protein interactions (2012)
  • Author(s): Nishida N, Shimada I.
  • Journal Title: Methods Mol Biol Volume: 757 Pages: 129-137
  • DOI: 10.1007/978-1-61779-166-6_10
  • ISBN: 9781617791659, 9781617791666
  • Peer Reviewed
• [Journal Article] Isotopic labeling of heterologous proteins in the yeast Pichia pastoris and Kluyveromyces lactis (2012)
  • Author(s): Sugiki T, Ichikawa O, Miyazawa-Onami M, Shimada I, Takahashi H.
  • Journal Title: Methods Mol Biol Volume: 831 Pages: 19-36
  • DOI: 10.1007/978-1-61779-480-3_2
  • ISBN: 9781617794797, 9781617794803
  • Peer Reviewed
• [Journal Article] Atypical membrane-embedded p47^<phox> PI(3,4)P_2 binding site on PX domain revealed by NMR (2012)
  • Author(s): Stampoulis P, Ueda T, Matsumoto M, Terasawa H, Miyano K, Sumimoto H, and Shimada I
  • Journal Title: J. Biol. Chem Volume: 287 Issue: 21 Pages: 17848-17859
  • DOI: 10.1074/jbc.m111.332874
  • Peer Reviewed
• [Journal Article] Structural basis for the modulation of the gating property of G protein-gated inwardly rectifying potassium ion channel (GIRK)by the i/o-family G protein α subunit (Gdi_<i/o>) (2012)
  • Author(s): 間瀬瑶子
  • Journal Title: The Journal of Biological Chemistry Volume: 287 Issue: 23 Pages: 19537-19549
  • DOI: 10.1074/jbc.m112.353888
  • Peer Reviewed
• [Journal Article] Segmental isotopic labeling of a 140 kDa dimeric multi-domain protein CheA from Escherichia coli by expressed protein ligation and protein trans-splicing (2012)
  • Author(s): Minato Y, Ueda T, Machiyama A, Shimada l, Iwai H
  • Journal Title: Journal of Biomolecular NMR Volume: 53 Issue: 3 Pages: 191-207
  • DOI: 10.1007/s10858-012-9628-3
  • Peer Reviewed
• [Journal Article] NMR study of ligand release from asialoglycoprotein receptor under solution conditions in early endosomes (2012)
  • Author(s): Onizuka T, Shimizu H, Moriwaki Y, Nakano T, Kanai S, Shimada I, Takahashi H.
  • Journal Title: FEBS J Volume: 279 Issue: 15 Pages: 2645-2656
  • DOI: 10.1111/j.1742-4658.2012.08643.x
  • Peer Reviewed
• [Journal Article] Structural basis for the Golgi association by the pleckstrin homology domain of the ceramide trafficking protein (CERT) (2012)
  • Author(s): Sugiki T, Takeuchi K, Yamaji T, Takano T, Tokunaga Y, Kumagai K, Hanada K, Takahashi H, Shimada I.
  • Journal Title: J Biol Chem Volume: 287 Pages: 33706-33718
  • Peer Reviewed
• [Journal Article] Structural Basis of Efficient Electron Transport between Photosyn thetic Membrane Proteins and Plastocyanin in Spinach Revealed using Nuclear Magnetic Resonance (2012)
  • Author(s): Takumi Ueda, Naoko Nomoto, Masamichi Koga, Hiroki Ogasa, Yuuta Ogawa, Masahiko Matsumoto, Pavlos Stampoulis, Koji Sode, Hiroaki Terasawa and Ichio Shimada
  • Journal Title: Plant Cell Volume: 24 Issue: 10 Pages: 4173-4186
  • DOI: 10.1105/tpc.112.102517
  • Peer Reviewed
• [Journal Article] Functional dynamics of proteins revealed by solution NMR (2012)
  • Author(s): Osawa M, Takeuchi K, Ueda T, Nishida N, Shimada I.
  • Journal Title: Curr Opin Struct Biol Volume: 22 Issue: 5 Pages: 660-669
  • DOI: 10.1016/j.sbi.2012.08.007
  • Peer Reviewed
• [Journal Article] Backbone resonance assignments for G protein α(i3) subunit in the GTP-bound state (2012)
  • Author(s): Mase Y, Yokogawa M, Osawa M, Shimada I.
  • Journal Title: Biomol NMR Assign Volume: 6 Issue: 2 Pages: 217-220
  • DOI: 10.1007/s12104-012-9361-6
  • Peer Reviewed
• [Journal Article] Spatial distribution of cytoplasmic domains of the Mg(2+)-transporter MgtE, in a solution lacking Mg(2+), revealed by paramagnetic relaxation enhancement (2012)
  • Author(s): Imai S, Maruyama T, Osawa M, Hattori M, Ishitani R, Nureki O, Shimada I.
  • Journal Title: Biochim Biophys Acta Volume: 1824 Issue: 10 Pages: 1129-1135
  • DOI: 10.1016/j.bbapap.2012.06.008
  • Peer Reviewed
• [Journal Article] Biological role of the two overlapping poly(A)-binding protein interacting motifs 2 (PAM2) of eukaryotic releasing factor eRF3 in mRNA decay. (2012)
  • Author(s): Osawa M, Hosoda N, Nakanishi T, Uchida N, Kimura T, Imai S, Machiyama A, Katada T, Hoshino S, Shimada I.
  • Journal Title: RNA Volume: 18 Issue: 11 Pages: 1957-1967
  • DOI: 10.1261/rna.035311.112
  • Peer Reviewed
• [Journal Article] Functional equilibrium of the KcsA structure revealed by NMR (2012)
  • Author(s): Imai S, Osawa M, Mita K, Toyonaga S, Machiyama A, Ueda T, Takeuchi K, Oiki S, Shimada I.
  • Journal Title: J Biol Chem Volume: 287 Issue: 47 Pages: 39634-39641
  • DOI: 10.1074/jbc.m112.401265
  • Peer Reviewed
• [Journal Article] An NMR method to study protein-protein interaction (2012)
  • Author(s): Noritaka Nishida, Ichio Shimada
  • Journal Title: Methods Mol.Biol. Volume: 757 Pages: 129-37
  • Peer Reviewed
• [Journal Article] Isotopic labeling of heterologous proteins in the yeast Pichia pastoris and Kluyveromyces lactis (2012)
  • Author(s): Toshihiko Sugiki, Osamu Ichikawa, Mayumi Miyazawa, -Onami, Ichio Shimada, Hideo Takahashi
  • Journal Title: Methods Mol.Biol.(2012)831,19-36 Volume: 831 Pages: 19-36
  • Peer Reviewed
• [Journal Article] CD44の準安定なヒアルロン酸認識機構と細胞ローリング (2011)
  • Author(s): 西田紀貴,嶋田一夫
  • Journal Title: 生化学 Volume: 83(10) Pages: 893-901
  • NAID: 10029850105
  • URL: http://www.jbsoc.or.jp/seika/wp-content/uploads/2013/05/83-10-02.pdf
• [Journal Article] 共有結合を用いた平衡シフトによる過渡的タンパク質複合体からの構造情報の取得 (2011)
  • Author(s): 神田大輔,齊藤貴士
  • Journal Title: 生化学 Volume: 83(10) Pages: 902-911
  • NAID: 10029850124
  • URL: http://www.jbsoc.or.jp/seika/wp-content/uploads/2013/05/83-10-03.pdf
• [Journal Article] 細胞膜上におけるトロンボポエチン受容体の一分子ダイナミクス (2011)
  • Author(s): 坂本明彦、加藤尚志、船津高志
  • Journal Title: 生化学 Volume: 83(10) Pages: 912-919
  • NAID: 10029850156
  • URL: http://www.jbsoc.or.jp/seika/wp-content/uploads/2013/05/83-10-04.pdf
• [Journal Article] 生細胞でのタンパク質選択的なケミカルラベリングの新手法 (2011)
  • Author(s): 松尾和哉,浜地格
  • Journal Title: 生化学 Volume: 83(10) Pages: 920-929
  • NAID: 10029850190
  • URL: http://www.jbsoc.or.jp/seika/wp-content/uploads/2013/05/83-10-05.pdf
• [Journal Article] ケモカインによる白血球,癌細胞の生体内移動調節とケモカイン共働作用の関与 (2011)
  • Author(s): 早坂晴子,岡田麻里,白忠彬,黒田康嵩,吉田淳一,宮坂昌之
  • Journal Title: 生化学 Volume: 83(10) Pages: 920-929
  • NAID: 10029850204
  • URL: http://www.jbsoc.or.jp/seika/wp-content/uploads/2013/05/83-10-06.pdf
• [Journal Article] Rapid Identification of Protein-Protein Interfaces and Construction of Complex Model Based on Multiple Unassigned Signals By Using Time-sharing NMR Measurement (2011)
  • Author(s): Yuya Kodama, Michael L.Reese, Nobuhisa Shimba, Volker Dotsch, Ei-ichiro Suzuki, Ichio Shimada, Hideo Takahashi
  • Journal Title: J.Struct.Biol. Volume: 174 Pages: 434-42
  • Peer Reviewed
• [Journal Article] Affinity transfer to human protein by CDR3 grafting of camelid VHH (2011)
  • Author(s): Hidetoshi Inoue, Akiko IIhara, Hideo Takahashi, Ichio Shimada, Isao Ishida, Yoshitake Maeda
  • Journal Title: Protein Sci. Volume: 20 Pages: 1971-81
  • Peer Reviewed
• [Journal Article] Protein-ligand docking guided by ligand pharmacophore-mapping experiment by NMR (2011)
  • Author(s): Yoshifumi Fukunishi, Yumiko Mizukoshi, Koh Takeuchi, Ichio Shimada, Hideo Takahashi, Haruki Nakamura
  • Journal Title: J.Mol.Graph.Model. Volume: 31 Pages: 20-7
  • Peer Reviewed
• [Journal Article] An Accurate Pharmacophore Mapping Method by NMR (2011)
  • Author(s): Yumiko Mizukoshi, Aya Abe, Takeshi Takizawa, Hiroyuki Hanzawa, Yoshifumi Fukunishi, Ichio Shimada, Hideo Takahashi
  • Journal Title: Angew.Chem.In Ed Engl.(2011) Volume: (in press)
  • Peer Reviewed
• [Journal Article] Structure determination of a protein assembly by amino acid selective cross-saturation (2011)
  • Author(s): Eiji Kanamori, Shunsuke Igarashi, Masanori Osawa, Yoshifumi Fukunishi, Ichio Shimada, Haruki Nakamura
  • Journal Title: Proteins Volume: 79 Pages: 179-190
  • Peer Reviewed
• [Journal Article] HNCA-TOCSY-CANH experiments with alternate 13C-12C labeling : a set of 3D experiment with unique supra-sequential information for mainchain resonance assignment (2011)
  • Author(s): Koh Takeuchi, Maayan Gal, Hideo Takahashi, Ichio Shimada, Gerhard Wagner
  • Journal Title: J.Biomol.NMR Volume: 49 Pages: 17-26
  • Peer Reviewed
• [Journal Article] Production of isotopically labeled heterologous proteins in non-E.coli prokaryotic and eukaryotic cells (2010)
  • Author(s): Hideo Takahashi, Ichio Shimada
  • Journal Title: J.Biomol.NMR Volume: 46 Pages: 3-10
  • Peer Reviewed
• [Journal Article] Real-time assay method of lipid extraction activity (2010)
  • Author(s): Toshihiko Sugiki, Hideo Takahashi, Michiko Nagasu, Kentaro Hanada, Ichio Shimada
  • Journal Title: Anal.Biochem. Volume: 399 Pages: 162-167
  • Peer Reviewed
• [Journal Article] Structural Basis for Platelet Anti-aggregation by AT1-Receptor Antagonist Losartan via Glycoprotein VI (2010)
  • Author(s): Katsuki Ono, Hiroshi Ueda, Yoshitaka Yoshizawa, Daisuke Akazawa, Ryuji Tanimura, Ichio Shimada, Hideo Takahashi
  • Journal Title: J.Med.Chem. Volume: 53 Pages: 1917-1922
  • Peer Reviewed
• [Journal Article] Direct determination of the insulin-insulin receptor interface using transferred cross-saturation experiments (2010)
  • Author(s): Takefumi Nakamura, Hideo Takahashi, Mitsuo Takahashi, Nobuhisa Shimba, Ei-ichiro Suzuki, Ichio Shimada
  • Journal Title: J.Med.Chem. Volume: 53 Pages: 2087-2093
  • Peer Reviewed
• [Journal Article] Structural basis underlying the dual gate properties of KcsA (2010)
  • Author(s): Shunsuke Imai, Masanori Osawa, Koh Takeuchi, Ichio Shimada
  • Journal Title: Proc.Natl.Acad.Sci.USA. Volume: 107 Pages: 6216-6221
  • Peer Reviewed
• [Journal Article] Two-state conformational equilibrium of the hyaluronan-binding domain regulates adhesiveness of CD44 under flow condition (2010)
  • Author(s): Shinji Ogino, Noritaka Nishida, Ryo Umemoto, Miho Suzuki, Mitsuhiro Takeda, Hiroaki Terasawa, Joji Kitayama, Masanori Matsumoto, Haruko Hayasaka, Masayuki Miyasaka, Ichio Shimada
  • Journal Title: Structure Volume: 18 Pages: 649-656
  • Peer Reviewed
• [Journal Article] Precise structural determination of weakly binding peptides by utilizing dihedral angle constraints (2010)
  • Author(s): Yumiko Mizukoshi, Michiko Nagasu, Ichio Shimada, Hideo Takahashi
  • Journal Title: J.Biomol.NMR Volume: 46 Pages: 299-305
  • Peer Reviewed
• [Journal Article] NMR analyses of the interaction between CCR5 and its ligand using functional reconstitution of CCR5 in lipid bilayers (2010)
  • Author(s): Chie Yoshiura, Yutaka Kofuku, Takumi Ueda, Yoko Mase, Mariko Yokogawa, Masanori Osawa, Yuya Terashima, Kouji Matsushima, Ichio Shimada
  • Journal Title: J.Am.Chem.Soc. Volume: 132 Pages: 6768-6777
  • Peer Reviewed
• [Journal Article] Theoretical analyses of the transferred cross-saturation method (2010)
  • Author(s): Masahiko Matsumoto, Takumi Ueda, Ichio Shimada
  • Journal Title: J.Magn.Reson. Volume: 205 Pages: 114-124
  • Peer Reviewed
• [Journal Article] Backbone resonance assignments for the ligand binding subunit of the histidine permease complex (HisJ) from Escherichia coli, under histidine-bound and unbound states. (2010)
  • Author(s): Igarashi S, Osawa M, Ozawa S, Shimada I.
  • Journal Title: Biomol NMR Assign. Volume: 4 Pages: 7-20
  • Peer Reviewed
• [Journal Article] NMR structure of the calponin homology domain of human IQGAP1 and its implications for the actin recognition mode (2010)
  • Author(s): Ryo Umemotoa, Noritaka Nishida, Shinji Oginoa, Ichio Shimada
  • Journal Title: J.Biomol.NMR Volume: 48 Pages: 59-64
  • Peer Reviewed
• [Journal Article] Quantitative characterization of the Tob interactions provides the thermodynamic basis on the translation termination-coupled deadenylase regulation (2010)
  • Author(s): Lin Ruan, Masanori Osawa, Nao Hosoda, Shunsuke Imai, Asako Machiyama, Toshiaki Katada, Shin-ichi Hoshino, Ichio Shimada
  • Journal Title: J.Biol.Chem. Volume: 285 Pages: 27624-27631
  • Peer Reviewed
• [Journal Article] Structural investigation of the interaction between the periplasmic chaperone LolA and the outer membrane receptor LolB using NMR (2009)
  • Author(s): Shingo Nakada
  • Journal Title: J.Biol.Chem. 284 Pages: 24634-24643
  • Peer Reviewed
• [Journal Article] Observation of NMR signals from proteins introduced into living mammalian cells by reversible membrane permeabilization using a pore-forming toxin, Streptolysin O (2009)
  • Author(s): Shinji Ogino
  • Journal Title: J.Am.Chem.Soc. 131 Pages: 10834-10835
  • Peer Reviewed
• [Journal Article] Interaction between chemokine SDF-1 and its GPCR CXCR4 investigated by NMR (2009)
  • Author(s): Yutaka Kofuku
  • Journal Title: J.Biol.Chem. 284 Pages: 35240-35250
  • Peer Reviewed
• [Presentation] NMR studies on drug target proteins (2015)
  • Author(s): Ichio Shimada
  • Organizer: The 4th International Symposium on Drug Discovery and Design by NMR
  • Place of Presentation: 神奈川県横浜市
  • Year and Date: 2015-02-05
• [Presentation] Functional dynamics of GPCR in micelles and lipid bilayers (2015)
  • Author(s): Ichio Shimada
  • Organizer: Advanced Stable Isotopic Labelling for Integrated Structural Biology AILM 2015
  • Place of Presentation: Grenoble, France
  • Year and Date: 2015-02-03
  • Invited
• [Presentation] Functional Equilibrium of Membrane Proteins by NMR (2014)
  • Author(s): Ichio Shimada
  • Organizer: Internatinal Connfrence of Magnetic Resonance in Biological Systems
  • Place of Presentation: Dallas, USA
  • Year and Date: 2014-08-26
  • Invited
• [Presentation] Functional Equilibrium of Membrane Proteins (2014)
  • Author(s): Ichio Shimada
  • Organizer: the EMBO Workshop on “Magnetic Resonance for Cellular Structural Biology”
  • Place of Presentation: Principina Terra, Italy
  • Year and Date: 2014-06-01
  • Invited
• [Presentation] Functional Equilibrium of Membrane Proteins (2014)
  • Author(s): Ichio Shimada
  • Organizer: The Spring International Convention of the Pharmaceutical Society of Korea
  • Place of Presentation: Seoul, Korea
  • Year and Date: 2014-04-17
  • Invited
• [Presentation] メチル化CpG結合蛋白質MBD4による緩い基質DNA認識 (2013)
  • Author(s): 有吉眞理子,大谷淳二,白川昌宏
  • Organizer: 第51回日本生物物理学会年会ワークショップ「過渡的複合体が関わる生命現象の統合的理解」
  • Place of Presentation: 京都府京都市
  • Year and Date: 2013-10-29
• [Presentation] タンパク質結晶中に意図的に創り出した空間を使って,タンパク質に結合した状態のリガンドの大振幅運動を解析する (2013)
  • Author(s): 神田大輔
  • Organizer: 第51回日本生物物理学会年会ワークショップ「過渡的複合体が関わる生命現象の統合的理解」
  • Place of Presentation: 京都府京都市
  • Year and Date: 2013-10-29
• [Presentation] ゲル包埋型バイオリアクターを用いた生細胞内蛋白質間相互作用のNMR観測 (2013)
  • Author(s): 西田紀貴,嶋田一夫
  • Organizer: 第51回日本生物物理学会年会ワークショップ「過渡的複合体が関わる生命現象の統合的理解」
  • Place of Presentation: 京都府京都市
  • Year and Date: 2013-10-29
• [Presentation] タンパク質解析のための生細胞でのケミカルラベリンク (2013)
  • Author(s): 浜地格
  • Organizer: 第51回日本生物物理学会年会ワークショップ「過渡的複合体が関わる生命現象の統合的理解」
  • Place of Presentation: 京都府京都市
  • Year and Date: 2013-10-29
• [Presentation] ケモカイン受容体多量体形成による細胞動態の調節 (2013)
  • Author(s): 早坂晴子,小林大地,宮坂昌之
  • Organizer: 第51回日本生物物理学会年会ワークショップ「過渡的複合体が関わる生命現象の統合的理解」
  • Place of Presentation: 京都府京都市
  • Year and Date: 2013-10-29
• [Presentation] 一回膜貫通型サイトカイン受容体Mpl二量体化の一分子蛍光解析 (2013)
  • Author(s): 坂本明彦,加藤尚志,船津高志
  • Organizer: 第51回日本生物物理学会年会ワークショップ「過渡的複合体が関わる生命現象の統合的理解」
  • Place of Presentation: 京都府京都市
  • Year and Date: 2013-10-29
• [Presentation] NMRによる膜タンパク質の機能解明 (2013)
  • Author(s): 嶋田一夫
  • Organizer: よこはまNMR構造生物学研究会
  • Place of Presentation: 神奈川県横浜市
  • Year and Date: 2013-03-22
• [Presentation] Functional Equilibrium of Membrane Proteins (2013)
  • Author(s): 嶋田一夫
  • Organizer: Frontiers of NMR in Biology, Keystone Symposia,
  • Place of Presentation: Snowbird, Utah, USA
  • Year and Date: 2013-01-17
• [Presentation] Functional Dynamics of Membrane Proteins by NMR (2012)
  • Author(s): 嶋田一夫
  • Organizer: 第85回生化学会年会
  • Place of Presentation: 福岡県福岡市
  • Year and Date: 2012-12-11
  • Invited
• [Presentation] NMRによる膜タンパク質の機能解明 (2012)
  • Author(s): 嶋田一夫
  • Organizer: 第34回生体膜と薬物の相互作用シンポジウム
  • Place of Presentation: 京都府京都市
  • Year and Date: 2012-11-15
  • Invited
• [Presentation] Functional Dynamics of Membrane Proteins (2012)
  • Author(s): 嶋田一夫
  • Organizer: The 3rd International Symposium on Drug Discovery and Design by NM
  • Place of Presentation: 神奈川県横浜市
  • Year and Date: 2012-10-11
  • Invited
• [Presentation] Functional Dynamics of Membrane Proteins (2012)
  • Author(s): 嶋田一夫
  • Organizer: ICMRBS
  • Place of Presentation: リヨン、フランス
  • Year and Date: 2012-08-21
  • Invited
• [Presentation] 膜タンパク質を対象としたNMR創薬基盤技術 (2012)
  • Author(s): 嶋田一夫
  • Organizer: 第25回バイオメディカル分析科学シンポジウム
  • Place of Presentation: 東京都港区
  • Year and Date: 2012-08-09
  • Invited
• [Presentation] ＮＭＲによる膜タンパク質の機能解明 (2012)
  • Author(s): 嶋田一夫
  • Organizer: 第13回若手NMR研究会
  • Place of Presentation: 北海道、支笏湖
  • Year and Date: 2012-07-20
  • Invited
• [Presentation] NMRを用いた膜タンパク質の機能解明 (2012)
  • Author(s): 嶋田一夫
  • Organizer: 第11回日本蛋白質科学会
  • Place of Presentation: 愛知県名古屋市
  • Year and Date: 2012-06-22
  • Invited
• [Presentation] Dynamical aspects of membrane proteins (2012)
  • Author(s): 嶋田一夫
  • Organizer: INPEC2012
  • Place of Presentation: 台北、台湾
  • Year and Date: 2012-04-06
  • Invited
• [Presentation] A novel in-cell NMR technique to determine the binding interface of functional protein complexes in mammalian cells (2012)
  • Author(s): 久保智史、荻野新治、宇田川侑子、宝田理、西田紀貴、嶋田一夫
  • Organizer: 第132回日本薬学会年会日本薬学会
  • Place of Presentation: 北海道大学(札幌)
  • Year and Date: 2012-03-30
• [Presentation] The effect of tensile force on CD44 mediated cell rolling (2012)
  • Author(s): 鈴木隆、鈴木美穂、西田紀貴、嶋田一夫
  • Organizer: 第132回日本薬学会年会日本薬学会
  • Place of Presentation: 北海道大学(札幌)
  • Year and Date: 2012-03-30
• [Presentation] Elucidation of regulatory mechanism for arrestin activation by G-protein coupled receptor (2012)
  • Author(s): 白石勇太郎, 幸福裕, 奥出順也, 吉浦知絵, 阿内康平, 上田卓見, 嶋田一夫
  • Organizer: 第132回日本薬学会年会日本薬学会
  • Place of Presentation: 北海道大学(札幌)(ポスター)
  • Year and Date: 2012-03-30
• [Presentation] Elucidation of the mechanism of analgesic tolerance by chronic administration of morphine (2012)
  • Author(s): 奥出順也, 吉浦知絵, 白石勇太郎, 幸福裕, 上田卓見, 嶋田一夫
  • Organizer: 第132回日本薬学会年会日本薬学会
  • Place of Presentation: 北海道大学(札幌)
  • Year and Date: 2012-03-30
• [Presentation] Dynamical Aspects of Membrane Proteins (2011)
  • Author(s): Ichio Shimada
  • Organizer: MBSJ2011
  • Place of Presentation: パシフィコ横浜(横浜)(招待講演)
  • Year and Date: 2011-12-14
• [Presentation] Structural Mechanism for the Affinity-Regulation of Cytoplasmic Dynein (2011)
  • Author(s): 宝田理, 西田紀貴、吉川雅英、嶋田一夫
  • Organizer: 第34回日本分子生物学会年会日本分子生物学会
  • Place of Presentation: パシフィコ横浜(横浜)
  • Year and Date: 2011-12-13
• [Presentation] Structural investigation of voltage-sensing mechanism of voltage-dependent K+ channels (2011)
  • Author(s): 原田瞳, 大澤匡範, 小澤新一郎, 木村友美, 野崎智裕, 嶋田一夫
  • Organizer: 第34回日本分子生物学会年会日本分子生物学会
  • Place of Presentation: パシフィコ横浜(横浜)(ポスター)
  • Year and Date: 2011-12-13
• [Presentation] Structural basis for the inhibition of voltage-dependent potassium (Kv) channels by gating modifier toxins (2011)
  • Author(s): 小澤新一郎、大澤匡範、木村友美、原田瞳、野崎智裕、嶋田一夫
  • Organizer: 第34回日本分子生物学会年会日本分子生物学会
  • Place of Presentation: パシフィコ横浜(横浜)(ポスター)
  • Year and Date: 2011-12-13
• [Presentation] Dynamical Aspects of Membrane Proteins (2011)
  • Author(s): Ichio Shimada
  • Organizer: AIMECS11
  • Place of Presentation: 京王プラザホテル(東京)(招待講演)
  • Year and Date: 2011-12-02
• [Presentation] Dynamical Aspects of Membrane Proteins (2011)
  • Author(s): Ichio Shimada
  • Organizer: The 4th Asia-Pacific NMR Symposium
  • Place of Presentation: Central Garden Beijing Hotel(北京、中国)(招待講演)
  • Year and Date: 2011-10-17
• [Presentation] Functional Analyses of Membrane Proteins by NMR (2011)
  • Author(s): Ichio Shimada
  • Organizer: The 9th International Symposium for Future Drug Discovery and Medical Care
  • Place of Presentation: 北海道大学(札幌)(招待講演)
  • Year and Date: 2011-09-29
• [Presentation] 1分子イメージングによってわかるタンパク質の働き (2011)
  • Author(s): 船津高志
  • Organizer: 日本バイオイメージング学会第20回学術集会公開講座
  • Place of Presentation: 千歳市民文化センター、千歳市、北海道
  • Year and Date: 2011-08-31
• [Presentation] NMRによる GPCR・リガンド相互作用解析 (2011)
  • Author(s): 嶋田一夫
  • Organizer: 新学術領域研究「過渡的複合体」公開シンポジウム
  • Place of Presentation: 東京大学薬学部東京
  • Year and Date: 2011-07-21
• [Presentation] 共有結合を用いた平衡シフトによる過渡的タンパク質複合体の安定化とその応用 (2011)
  • Author(s): 神田大輔
  • Organizer: 新学術領域研究「過渡的複合体」公開シンポジウム
  • Place of Presentation: 東京大学薬学部東京
  • Year and Date: 2011-07-21
• [Presentation] 細胞膜上におけるトロンボポエチン受容体の一分子ダイナミクス (2011)
  • Author(s): 船津高志
  • Organizer: 新学術領域研究「過渡的複合体」公開シンポジウム
  • Place of Presentation: 東京大学薬学部東京
  • Year and Date: 2011-07-21
• [Presentation] 生細胞での蛋白質の選択的ケミカルラベル化と機能化 (2011)
  • Author(s): 浜地格
  • Organizer: 新学術領域研究「過渡的複合体」公開シンポジウム
  • Place of Presentation: 東京大学薬学部東京
  • Year and Date: 2011-07-21
• [Presentation] 磁気共鳴を使った生細胞における分子動態の計測手法の開発 (2011)
  • Author(s): 白川昌宏
  • Organizer: 新学術領域研究「過渡的複合体」公開シンポジウム
  • Place of Presentation: 東京大学薬学部東京
  • Year and Date: 2011-07-21
• [Presentation] 白血球、癌細胞の生体内動態調節におけるケモカイン共働作用 (2011)
  • Author(s): 早坂晴子
  • Organizer: 新学術領域研究「過渡的複合体」公開シンポジウム
  • Place of Presentation: 東京大学薬学部東京
  • Year and Date: 2011-07-21
• [Presentation] Molecular interaction of membrane proteins by NMR (2011)
  • Author(s): Ichio Shimada
  • Organizer: Functional Proteomics & KIST Symposium
  • Place of Presentation: Korea Institute of Science and Technology, International Cooperation Bldg(ソウル、韓国)(招待講演)
  • Year and Date: 2011-02-02
• [Presentation] NMR法によるactinとactin結合タンパク質との相互作用解析法の開発 (2010)
  • Author(s): 黄淑嫻、梅本良、上田太郎、西田紀貴、嶋田一夫
  • Organizer: 第33回日本分子生物学会年会 第83回日本生化学会大会合同大会
  • Place of Presentation: 神戸ポートアイランド,兵庫県
  • Year and Date: 2010-12-08
• [Presentation] 高分子量蛋白質の構造解析に適した安定同位体ラベル法および測定法の開発 (2010)
  • Author(s): 竹内恒、高橋栄夫、嶋田一夫、Gerhard Wagner
  • Organizer: 第49回NMR討論会
  • Place of Presentation: 船堀タワーホール,東京都
  • Year and Date: 2010-11-15
• [Presentation] Dynamical aspects of membrane proteins (2010)
  • Author(s): 嶋田一夫
  • Organizer: Max Planck Institute seminar
  • Place of Presentation: Gottingen, Germany
  • Year and Date: 2010-10-21
• [Presentation] Dynamical aspects of membrane proteins (2010)
  • Author(s): 嶋田一夫
  • Organizer: Technische Universitat Munchen/Helmholtz Zentrum Munchen seminar
  • Place of Presentation: Munchen, Germany
  • Year and Date: 2010-10-20
• [Presentation] Dynamical aspects of membrane proteins by NMR (2010)
  • Author(s): 嶋田一夫
  • Organizer: The International Network of Protein Engineering Centres (INPEC) 2010
  • Place of Presentation: Uppsala, Sweden
  • Year and Date: 2010-10-08
• [Presentation] The 2nd International Symposium on Drug Discovery and Design by NMR (2010)
  • Author(s): 嶋田一夫
  • Organizer: Functional analyses of membrane proteins by NMR
  • Place of Presentation: 横浜市立大学,神奈川県
  • Year and Date: 2010-09-30
• [Presentation] NMRを用いた膜タンパク質の機能解明 (2010)
  • Author(s): 嶋田一夫
  • Organizer: 日本分光学会NMR分光部会シンポジウム
  • Place of Presentation: 東京大学,東京都
  • Year and Date: 2010-09-08
• [Presentation] Dynamical aspects of membrane proteins (2010)
  • Author(s): 嶋田一夫
  • Organizer: Frankfurt University seminar
  • Place of Presentation: Frankfurt, Germany
  • Year and Date: 2010-09-06
• [Presentation] Dynamical aspects of membrane proteins (2010)
  • Author(s): 嶋田一夫
  • Organizer: International Conference on Magnetic Resonance in Biological Systems
  • Place of Presentation: Cairns, Australia
  • Year and Date: 2010-08-23
• [Presentation] NMRによるケモカイン受容体・ケモカイン相互作用解析 (2010)
  • Author(s): 嶋田一夫
  • Organizer: 第34回阿蘇シンポジウム
  • Place of Presentation: 阿蘇リゾートグランヴィリオホテル,熊本県
  • Year and Date: 2010-07-30
• [Presentation] -超高磁場が拓く生体系NMR:最新技術と応用-膜タンパク質のダイナミックスと機能 (2010)
  • Author(s): 嶋田一夫
  • Organizer: 大阪大学蛋白質研究所セミナー
  • Place of Presentation: 大阪大学,大阪府
  • Year and Date: 2010-07-29
• [Presentation] NMRによる膜タンパク質の機能解析 (2010)
  • Author(s): 嶋田一夫
  • Organizer: 日本学術振興会、回折構造生物学第169委員会、第32回研究会
  • Place of Presentation: ゆうぽうと,東京都
  • Year and Date: 2010-07-20
• [Presentation] Structural bases of the interactions between chemokines and their G-protein-coupled receptors (2010)
  • Author(s): 嶋田一夫
  • Organizer: Symposium on Structure and Folding of Disease Related Proteins
  • Place of Presentation: Seoul National University, Korea
  • Year and Date: 2010-07-10
• [Presentation] Structural bases of the interactions between chemokines and their G-protein-coupled receptors (2010)
  • Author(s): 嶋田一夫
  • Organizer: EUROMAR/ISMAR
  • Place of Presentation: Florence, Italy
  • Year and Date: 2010-07-06
• [Presentation] 過渡的複合体が関わる生命現象の統合的理解 (2010)
  • Author(s): 嶋田一夫
  • Organizer: 第10回日本蛋白質科学会年会ワークショップ「過渡的複合体の視点から生命現象を捉えなおす」
  • Place of Presentation: 北海道札幌市
  • Year and Date: 2010-06-16
• [Presentation] 準安定な分子複合体から構造情報を得るための新戦略 (2010)
  • Author(s): 神田大輔
  • Organizer: 第10回日本蛋白質科学会年会ワークショップ「過渡的複合体の視点から生命現象を捉えなおす」
  • Place of Presentation: 北海道札幌市
  • Year and Date: 2010-06-16
• [Presentation] トロンボポエチンシグナルの上流部は脂質ラフトによって制御されている (2010)
  • Author(s): 坂本明彦、加藤尚志、船津高志
  • Organizer: 第10回日本蛋白質科学会年会ワークショップ「過渡的複合体の視点から生命現象を捉えなおす」
  • Place of Presentation: 北海道札幌市
  • Year and Date: 2010-06-16
• [Presentation] 細胞での蛋白質選択的ケミカルラベリングの新手法 (2010)
  • Author(s): 浜地格
  • Organizer: 第10回日本蛋白質科学会年会ワークショップ「過渡的複合体の視点から生命現象を捉えなおす」
  • Place of Presentation: 北海道札幌市
  • Year and Date: 2010-06-16
• [Presentation] ケモカインレセプターの準安定状態と細胞動態 (2010)
  • Author(s): 早坂晴子、吉村洋美、白忠彬、宮坂昌之
  • Organizer: 第10回日本蛋白質科学会年会ワークショップ「過渡的複合体の視点から生命現象を捉えなおす」
  • Place of Presentation: 北海道札幌市
  • Year and Date: 2010-06-16
• [Presentation] In-cell NMR法による細胞内環境下の蛋白質の構造と機能の解析 (2010)
  • Author(s): 白川昌宏
  • Organizer: 第10回日本蛋白質科学会年会ワークショップ「過渡的複合体の視点から生命現象を捉えなおす」
  • Place of Presentation: 北海道札幌市
  • Year and Date: 2010-06-16
• [Presentation] 過渡的複合体が関わる生命現象の統合的理解 (2010)
  • Author(s): 嶋田一夫
  • Organizer: 第10回日本蛋白質科学会年会
  • Place of Presentation: 札幌コンベンションセンター,北海道
  • Year and Date: 2010-06-16
• [Presentation] Functional analyses of membrane proteins by NMR (2010)
  • Author(s): 嶋田一夫
  • Organizer: COLD SPRING HARBOR ASIA CONFERENCES
  • Place of Presentation: Suzhou, China
  • Year and Date: 2010-05-13
• [Presentation] Protein recognition by NMR (2009)
  • Author(s): Ichio Shimada
  • Organizer: International Network of Protein Engineering Conference
  • Place of Presentation: Itamambuca, Brasil
  • Year and Date: 2009-10-26
• [Presentation] Functional Equilibrium of Membrane Proteins
  • Author(s): 嶋田一夫
  • Organizer: 54th Experimental Nuclear Magnetic Resonance Conference
  • Place of Presentation: Asilomar, California, USA
  • Invited
• [Presentation] Functional Equilibrium of Membrane Proteins
  • Author(s): 嶋田一夫
  • Organizer: International Conference on Structural Genomics 2013
  • Place of Presentation: 北海道札幌市
  • Invited
• [Presentation] Functional Equilibrium of GPCR
  • Author(s): 嶋田一夫
  • Organizer: Symposium “Perspectives of NMR in drug discovery
  • Place of Presentation: Novartis, Basel, Switzerland
  • Invited
• [Presentation] Functional Equilibrium of GPCR
  • Author(s): 嶋田一夫
  • Organizer: 5th Asia-Pacific NMR Symposium in conjunction with ANZNAG2013
  • Place of Presentation: Brisbane, Australia
  • Invited
• [Presentation] NMR を用いた高分子量タンパク質複合体の相互作用解析法の開発と応用
  • Author(s): 嶋田一夫
  • Organizer: 第36回日本分子生物学会年会
  • Place of Presentation: 兵庫県神戸市
  • Invited
• [Book] Encyclopedia of Biophysics(GCR.Roberts (ed.)) (2011)
  • Author(s): Ichio Shimada
  • Total Pages: 1
  • Publisher: Springer-Verlag Berlin Heidelberg Ichio Shimada
• [Remarks] 過渡的複合体 領域HP
  • URL: http://ishimada.f.u-tokyo.ac.jp/public_html/tmc/newsletter/newsletter.html
• [Remarks] 領域まとめ国際シンポジウム
  • URL: http://www.biophys.jp/news/lib/newsshow.php/2966
• [Remarks] 過渡的複合体 HP
  • URL: http://ishimada.f.u-tokyo.ac.jp/public_html/tmc/
• [Remarks] 過渡的複合体 領域HP
  • URL: http://ishimada.f.u-tokyo.ac.jp/public_html/tmc/
• [Remarks] 過渡的複合体 領域HP
  • URL: http://ishimada.f.u-tokyo.ac.jp/public_html/tmc/
• [Remarks]
  • URL: http://ishimada.f.u-tokyo.ac.jp/public_html/tmc/