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Organization of kinetics-driven supramolecular chemistry

Administrative Group

Project AreaKinetics-Driven Supramolecular Chemistry
Project/Area Number 21H05093
Research Category

Grant-in-Aid for Transformative Research Areas (B)

Allocation TypeSingle-year Grants
Review Section Transformative Research Areas, Section (II)
Research InstitutionTokyo University of Agriculture and Technology

Principal Investigator

Muraoka Takahiro  東京農工大学, 工学(系)研究科(研究院), 教授 (70509132)

Co-Investigator(Kenkyū-buntansha) 奥村 正樹  東北大学, 学際科学フロンティア研究所, 准教授 (50635810)
齋尾 智英  徳島大学, 先端酵素学研究所, 教授 (80740802)
Project Period (FY) 2021-08-23 – 2024-03-31
Project Status Completed (Fiscal Year 2023)
Budget Amount *help
¥15,470,000 (Direct Cost: ¥11,900,000、Indirect Cost: ¥3,570,000)
Fiscal Year 2023: ¥6,370,000 (Direct Cost: ¥4,900,000、Indirect Cost: ¥1,470,000)
Fiscal Year 2022: ¥5,460,000 (Direct Cost: ¥4,200,000、Indirect Cost: ¥1,260,000)
Fiscal Year 2021: ¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Keywords遅延制御 / 超分子化学 / タンパク質 / フォールディング / ミスフォールディング
Outline of Research at the Start

領域の研究活動を円滑かつ効果的に推進するため、主として以下の3つの活動を行う。(1)オンラインなど様々なメディアを用いた、領域内研究者同士の積極的なコミュニケーションを促し、異分野が有機的に連携した共同研究を活発に推進する。(2)大学院学生など若手研究者に対する研究支援、国内外の研究室への滞在型派遣、若手を中心とした研究交流を通じて、将来の学術領域を担う若手研究者の育成を目指す。(3)国際学術誌・国際会議への積極的な成果発表により、研究領域の認知度をあげ、将来的な国際研究領域の基盤を形成する。領域内研究者間での情報交換と領域全体の相互理解を深めるために、総括班主催の領域会議を半年毎に開催する。

Outline of Final Research Achievements

In order to promote area research effectively, area meetings and general group meetings were held every six months to discuss the progress and policies of each planned research project. Furthermore, activities were carried out to achieve the goals of the area research through initiatives to support collaboration research. In addition, domestic and foreign researchers related to our research in the fields of chemistry, physics and biology were invited and seminars were organized. In addition, joint symposia were held at the Chemical Society of Japan, the Protein Science Society of Japan, the Molecular Biology Society of Japan and the Biophysical Society of Japan, where the concept, approaches and results of activities in this field were widely reported. A website was also set up and efforts made to disseminate information online. Through these activities, we achieved the scientific construction of delay-controlled supramolecular chemistry through collaboration between different fields.

Academic Significance and Societal Importance of the Research Achievements

総括班活動を通じて、領域内研究者と学生を交えた分野横断研究を推進し、遅延制御による生命現象の理解と、新しい機能性分子開発につながった。領域会議や、学生主体の意見交換会、シンポジウムの開催を通じて、若手研究者の育成と、関連分野の国内外の研究者とのネットワーク構築を行うことができた。また、国内主要学会での共催シンポジウム開催や、ホームページ運営によって、幅広い分野の研究者や、一般の方への遅延制御超分子化学の情報発信を行うアウトリーチ活動を行うことができた。

Report

(4 results)
  • 2023 Annual Research Report   Final Research Report ( PDF )
  • 2022 Annual Research Report
  • 2021 Annual Research Report
  • Research Products

    (21 results)

All 2024 2023 2022 2021 Other

All Int'l Joint Research (5 results) Journal Article (5 results) (of which Int'l Joint Research: 1 results,  Peer Reviewed: 5 results,  Open Access: 3 results) Presentation (5 results) (of which Int'l Joint Research: 1 results,  Invited: 2 results) Remarks (3 results) Funded Workshop (3 results)

  • [Int'l Joint Research] 国立陽明交通大学(台湾)(その他の国・地域(台湾))

    • Related Report
      2023 Annual Research Report
  • [Int'l Joint Research] 国立陽明交通大学 (台湾)(その他の国・地域)

    • Related Report
      2022 Annual Research Report
  • [Int'l Joint Research] Korea Basic Science Institute(韓国)

    • Related Report
      2022 Annual Research Report
  • [Int'l Joint Research] KBSI(韓国)

    • Related Report
      2021 Annual Research Report
  • [Int'l Joint Research] 台湾国立交通大学(その他の国・地域(台湾))

    • Related Report
      2021 Annual Research Report
  • [Journal Article] Enzymatic and synthetic regulation of polypeptide folding2024

    • Author(s)
      Muraoka Takahiro、Okumura Masaki、Saio Tomohide
    • Journal Title

      Chemical Science

      Volume: 15 Issue: 7 Pages: 2282-2299

    • DOI

      10.1039/d3sc05781j

    • Related Report
      2023 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] ROS-responsive methionine-containing amphiphilic peptides impart enzyme-triggered phase transition and antioxidant cell protection2024

    • Author(s)
      Yoshika Hara, Ken Yoshizawa, Atsuya Yaguchi, Hirotsugu Hiramatsu, Noriyuki Uchida*, Takahiro Muraoka*
    • Journal Title

      Biomacromolecules

      Volume: - Issue: 6 Pages: 3499-3506

    • DOI

      10.1021/acs.biomac.4c00129

    • Related Report
      2023 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Semi-enzymatic acceleration of oxidative protein folding by <i>N</i>-methylated heteroaromatic thiols2023

    • Author(s)
      Okada Shunsuke、Matsumoto Yosuke、Takahashi Rikana、Arai Kenta、Kanemura Shingo、Okumura Masaki、Muraoka Takahiro
    • Journal Title

      Chemical Science

      Volume: 14 Issue: 28 Pages: 7630-7636

    • DOI

      10.1039/d3sc01540h

    • Related Report
      2023 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Self-assembling materials functionalizing bio-interfaces of phospholipid membranes and extracellular matrices2023

    • Author(s)
      Uchida Noriyuki、Muraoka Takahiro
    • Journal Title

      Chemical Communications

      Volume: 59 Issue: 64 Pages: 9687-9697

    • DOI

      10.1039/d3cc01875j

    • Related Report
      2023 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Biophysical elucidation of neural network and chemical regeneration of neural tissue2022

    • Author(s)
      Takahiro Muraoka, Tomohide Saio, Masaki Okumura
    • Journal Title

      Biophysics and Physicobiology

      Volume: 19 Issue: 0 Pages: n/a

    • DOI

      10.2142/biophysico.bppb-v19.0024

    • ISSN
      2189-4779
    • Related Report
      2022 Annual Research Report
    • Peer Reviewed
  • [Presentation] 速度論効果を利用する多段階蛋白質フォールディング促進2023

    • Author(s)
      村岡貴博
    • Organizer
      日本化学会 第103春季大会(2023)
    • Related Report
      2022 Annual Research Report
  • [Presentation] キネティクス操作に基づく酸化的蛋白質フォールディング制御2022

    • Author(s)
      村岡貴博
    • Organizer
      第22回日本蛋白質科学会年会
    • Related Report
      2022 Annual Research Report
  • [Presentation] 多段階反応制御によるタンパク質フォールディング促進2022

    • Author(s)
      村岡貴博
    • Organizer
      第45回日本分子生物学会年会
    • Related Report
      2022 Annual Research Report
  • [Presentation] Regulated folding and assembly of polypeptides for designing ECM-mimetic biomaterials2022

    • Author(s)
      Takahiro Muraoka
    • Organizer
      Protein Folding, Aggregation, Misfolding Disease, and Disease Crosstalk
    • Related Report
      2022 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Neurochemistry from Supramolecular Chemistry2022

    • Author(s)
      Takahiro Muraoka
    • Organizer
      Neuro2022
    • Related Report
      2022 Annual Research Report
    • Invited
  • [Remarks] 遅延制御超分子化学領域ホームページ

    • URL

      https://web.tohoku.ac.jp/KineticControl/

    • Related Report
      2022 Annual Research Report
  • [Remarks] 遅延制御超分子化学ホームページ

    • URL

      https://web.tohoku.ac.jp/KineticControl/

    • Related Report
      2021 Annual Research Report
  • [Remarks] 東京農工大学村岡研究室ホームページ

    • URL

      https://www.muraoka-lab.com

    • Related Report
      2021 Annual Research Report
  • [Funded Workshop] Protein Folding, Aggregation, Misfolding Disease, and Disease Crosstalk (3rd International Symposium on Kinetics-Driven Supramolecular Chemistry)2022

    • Related Report
      2022 Annual Research Report
  • [Funded Workshop] 2nd International Symposium on Kinetics-Driven Supramolecular Chemistry2022

    • Related Report
      2022 Annual Research Report
  • [Funded Workshop] 遅延制御超分子化学第1回国際シンポジウム2021

    • Related Report
      2021 Annual Research Report

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Published: 2021-10-22   Modified: 2025-01-30  

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