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Elucidation of the mechanisms of transcriptional unity by understanding spatiotemporal multifactorial interactions

Administrative Group

Project AreaElucidation of the mechanisms of transcriptional unity by understanding spatiotemporal multifactorial interactions
Project/Area Number 21H05158
Research Category

Grant-in-Aid for Transformative Research Areas (B)

Allocation TypeSingle-year Grants
Review Section Transformative Research Areas, Section (III)
Research InstitutionOsaka University

Principal Investigator

Nimura Keisuke  大阪大学, 大学院医学系研究科, 准教授 (00462713)

Co-Investigator(Kenkyū-buntansha) 高橋 秀尚  横浜市立大学, 医学研究科, 教授 (30423544)
仙石 徹  横浜市立大学, 医学部, 准教授 (60576312)
Project Period (FY) 2021-08-23 – 2024-03-31
Project Status Completed (Fiscal Year 2023)
Budget Amount *help
¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2023: ¥520,000 (Direct Cost: ¥400,000、Indirect Cost: ¥120,000)
Fiscal Year 2022: ¥520,000 (Direct Cost: ¥400,000、Indirect Cost: ¥120,000)
Fiscal Year 2021: ¥520,000 (Direct Cost: ¥400,000、Indirect Cost: ¥120,000)
Keywords転写ユニティー / 遺伝子発現 / 多因子間相互作用 / 転写 / 分子間相互作用 / 遺伝子発現制御
Outline of Research at the Start

細胞の機能発現には、ゲノム全体に分布する遺伝子の発現を適切に制御することが必須である。申請者らの研究成果から、転写制御は転写プロセス全体が密な相互連携によって一体化し、遺伝子発現を制御する機構の存在が示唆された。申請者らは、このような転写制御機構を転写ユニティー(Unity: 一体化)機構と呼ぶ。本研究では、時空間的な多因子間相互作用によって形成される転写ユニティー機構の解明を目指す。

Outline of Final Research Achievements

During the research period, 53 papers were published in our research group, with over four papers currently being submitted. These findings demonstrate the existence of a transcriptional unity mechanism, wherein transcription processes closely interact, and one process can influence all others. Additionally, we established a comprehensive identification method for multifactorial interactions using in situ biotinylation and the IBMseq method for spatial quantification of multifactorial interactions using antibody barcoding. Leveraging these methods, we aim to further elucidate the transcriptional unity mechanism and continue investigating disease mechanisms resulting from its disruption.

Academic Significance and Societal Importance of the Research Achievements

多因子間相互作用は核内の転写反応だけではなく、生体・細胞が外部刺激を受けて、その刺激に応答し遺伝子発現を誘導するために必要となる「シグナル伝達」「転写」「RNAプロセシング」「mRNAの核外輸送」「翻訳」においても必須であるが、その全貌は全く不明である。本研究において見出されてきた転写ユニティー機構のメカニズムは様々なプロセスが相互作用することで、精緻に遺伝子発現が制御されていることを明らかにした。さらに本研究領域で開発された新規の網羅的、定量的な多因子間相互作用解析法は転写ユニティー機構の解明研究だけでなく、様々な研究分野や臨床への応用も可能であると考え、今後さらに研究を進めていく。

Report

(4 results)
  • 2023 Annual Research Report   Final Research Report ( PDF )
  • 2022 Annual Research Report
  • 2021 Annual Research Report
  • Research Products

    (65 results)

All 2024 2023 2022 2021 Other

All Journal Article (34 results) (of which Int'l Joint Research: 11 results,  Peer Reviewed: 31 results,  Open Access: 23 results) Presentation (28 results) (of which Invited: 14 results) Remarks (2 results) Patent(Industrial Property Rights) (1 results) (of which Overseas: 1 results)

  • [Journal Article] Distinct Transcriptional Profiles in the Different Phenotypes of Neurofibroma from the Same Subject with Neurofibromatosis 12024

    • Author(s)
      Wang Wei-Ning、Koguchi-Yoshioka Hanako、Nimura Keisuke、Watanabe Rei、Tanemura Atsushi、Fujimoto Manabu、Wataya-Kaneda Mari
    • Journal Title

      Journal of Investigative Dermatology

      Volume: 144 Issue: 1 Pages: 133-141.e4

    • DOI

      10.1016/j.jid.2023.03.1688

    • Related Report
      2023 Annual Research Report
    • Peer Reviewed
  • [Journal Article] B細胞における転写制御機構2024

    • Author(s)
      二村圭祐
    • Journal Title

      臨床免疫・アレルギー科

      Volume: 81 Pages: 116-121

    • Related Report
      2023 Annual Research Report
  • [Journal Article] A Compact Reprogrammed Genetic Code for De Novo Discovery of Proteolytically Stable Thiopeptides2024

    • Author(s)
      Vinogradov Alexander A.、Zhang Yue、Hamada Keisuke、Kobayashi Shunsuke、Ogata Kazuhiro、Sengoku Toru、Goto Yuki、Suga Hiroaki
    • Journal Title

      Journal of the American Chemical Society

      Volume: 146 Issue: 12 Pages: 8058-8070

    • DOI

      10.1021/jacs.3c12037

    • Related Report
      2023 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Structure of the human Bre1 complex bound to the nucleosome2024

    • Author(s)
      Onishi Shuhei、Uchiyama Kotone、Sato Ko、Okada Chikako、Kobayashi Shunsuke、Hamada Keisuke、Nishizawa Tomohiro、Nureki Osamu、Ogata Kazuhiro、Sengoku Toru
    • Journal Title

      Nature Communications

      Volume: 15 Issue: 1 Pages: 2580-2580

    • DOI

      10.1038/s41467-024-46910-8

    • Related Report
      2023 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Chimera RNA transcribed from integrated HPV18 genome with adjacent host genomic region promotes oncogenic gene expression through condensate formation.2024

    • Author(s)
      Furugori K, Suzuki H, Abe R, Horiuchi K, Akiyama T, Hirose T, Toyoda A, Takahashi H
    • Journal Title

      Genes to Cells

      Volume: -

    • Related Report
      2023 Annual Research Report
    • Peer Reviewed
  • [Journal Article] GREB1 isoform 4 is specifically transcribed by MITF and required for melanoma proliferation2023

    • Author(s)
      Shinzawa Koei、Matsumoto Shinji、Sada Ryota、Harada Akikazu、Saitoh Kaori、Kato Keiko、Ikeda Satsuki、Hirayama Akiyoshi、Yokoi Kazunori、Tanemura Atsushi、Nimura Keisuke、Ikawa Masahito、Soga Tomoyoshi、Kikuchi Akira
    • Journal Title

      Oncogene

      Volume: 42 Issue: 42 Pages: 3142-3156

    • DOI

      10.1038/s41388-023-02803-6

    • Related Report
      2023 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Design and synthesis of 4-acetoxypentanamide derivatives of spliceostatin A and their biological evaluation towards prostate cancer treatment2023

    • Author(s)
      Hirabayashi Satoru、Tsuyuguchi Yuko、Li Yue、Ohta Noriko、Yoshikawa Yusuke、Lin Bangzhong、Fumimoto Megumi、Nunomura Kazuto、Suzuki Takeyuki、Haruta Junichi、Nimura Keisuke、Arisawa Mitsuhiro
    • Journal Title

      Bioorganic & Medicinal Chemistry Letters

      Volume: 91 Pages: 129333-129333

    • DOI

      10.1016/j.bmcl.2023.129333

    • Related Report
      2023 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Switching Prenyl Donor Specificities of Cyanobactin Prenyltransferases2023

    • Author(s)
      Zhang Yuchen、Hamada Keisuke、Satake Masayuki、Sengoku Toru、Goto Yuki、Suga Hiroaki
    • Journal Title

      Journal of the American Chemical Society

      Volume: 145 Issue: 44 Pages: 23893-23898

    • DOI

      10.1021/jacs.3c07373

    • Related Report
      2023 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Biallelic structural variations within FGF12 detected by long-read sequencing in epilepsy2023

    • Author(s)
      Ohori S., Miyauchi A., Osaka H., Lourenco C. M., Arakaki N., Sengoku T., Ogata K., Honjo R. S., Kim C. A., Mitsuhashi S., Frith M. C., Seyama R., Tsuchida N., Uchiyama Y., Koshimizu E., Hamanaka K., Misawa K., Miyatake S., Mizuguchi T., Saito K., Fujita A. and Matsumoto N.
    • Journal Title

      Life Sci Alliance

      Volume: 6 Issue: 8 Pages: e202302025-e202302025

    • DOI

      10.26508/lsa.202302025

    • Related Report
      2023 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Brain monoamine vesicular transport disease caused by homozygous SLC18A2 variants: A study in 42 affected individuals2023

    • Author(s)
      Saida K, Maroofian R, Sengoku T, Mitani T, Pagnamenta AT, Marafi D, Miyatake S, Lupski JR, Houlden H, Matsumoto N.
    • Journal Title

      Genet Med

      Volume: Jan;25(1) Issue: 1 Pages: 90-102

    • DOI

      10.1016/j.gim.2022.09.010

    • Related Report
      2023 Annual Research Report 2022 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] RNA Foci in Two bi‐Allelic RFC1 Expansion Carriers2023

    • Author(s)
      Wada Taishi、Doi Hiroshi, et al.
    • Journal Title

      Annals of Neurology

      Volume: 95 Issue: 3 Pages: 607-613

    • DOI

      10.1002/ana.26848

    • Related Report
      2023 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Sez6l2 autoimmunity in a large cohort study2023

    • Author(s)
      Abe M, Yaguchi H, Kudo A, Nagai A, Shirai S, Takahashi-Iwata I, Matsushima M, Nakamura N, Isahaya K, Yamano Y, Ashida S, Kasai T, Tanaka K, Watanabe M, Kondo T, Takahashi H, Hatakeyama S, Takekoshi A, Kimura A, Shimohata T, Yabe I.
    • Journal Title

      Journal of Neurology, Neurosurgery & Psychiatry

      Volume: 94 Issue: 8 Pages: 667-668

    • DOI

      10.1136/jnnp-2022-330194

    • Related Report
      2023 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] MED26‐containing Mediator may orchestrate multiple transcription processes through organization of nuclear bodies2023

    • Author(s)
      Suzuki Hidefumi、Furugori Kazuki、Abe Ryota、Ogawa Shintaro、Ito Sayaka、Akiyama Tomohiko、Horiuchi Keiko、Takahashi Hidehisa
    • Journal Title

      BioEssays

      Volume: 45 Issue: 4

    • DOI

      10.1002/bies.202200178

    • Related Report
      2023 Annual Research Report 2022 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Design and synthesis of ether derivatives of spliceostatin A and their biological evaluation towards prostate cancer treatment2023

    • Author(s)
      Hirabayashi Satoru、Li Yue、Ohta Noriko、Ishibashi Airi、Yoshikawa Yusuke、Lin Bangzhong、Fumimoto Megumi、Takehara Tsunayoshi、Nunomura Kazuto、Suzuki Takeyuki、Haruta Junichi、Nimura Keisuke、Arisawa Mitsuhiro
    • Journal Title

      Tetrahedron Letters

      Volume: 114 Pages: 154288-154288

    • DOI

      10.1016/j.tetlet.2022.154288

    • Related Report
      2022 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Pilot study for the treatment of cutaneous neurofibromas in neurofibromatosis type 1 patients using topical sirolimus gel2023

    • Author(s)
      Wataya-Kaneda Mari、Watanabe Yoshiyuki、Nakamura Ayumi、Yamamoto Kouji、Okada Kiyoshi、Maeda Shinichiro、Nimura Keisuke、Saga Kotaro、Katayama Ichiro
    • Journal Title

      Journal of the American Academy of Dermatology

      Volume: 88 Issue: 4 Pages: 877-880

    • DOI

      10.1016/j.jaad.2022.08.066

    • Related Report
      2022 Annual Research Report
    • Peer Reviewed
  • [Journal Article] DNA barcoding and gene expression recording reveal the presence of cancer cells with unique properties during tumor progression2022

    • Author(s)
      Umeki Yuka、Ogawa Noriaki、Uegaki Yuko、Saga Kotaro、Kaneda Yasufumi、Nimura Keisuke
    • Journal Title

      Cellular and Molecular Life Sciences

      Volume: 80 Issue: 1 Pages: 17-17

    • DOI

      10.1007/s00018-022-04640-4

    • Related Report
      2022 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Identification of Malignant Cell Populations Associated with Poor Prognosis in High-Grade Serous Ovarian Cancer Using Single-Cell RNA Sequencing2022

    • Author(s)
      Sumitani Naoki、Ishida Kyoso、Sawada Kenjiro、Kimura Tadashi、Kaneda Yasufumi、Nimura Keisuke
    • Journal Title

      Cancers

      Volume: 14 Issue: 15 Pages: 3580-3580

    • DOI

      10.3390/cancers14153580

    • Related Report
      2022 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Dual function of SF3B2 on chromatin and RNA to regulate transcription in head and neck squamous cell carcinoma2022

    • Author(s)
      Kitamura Koji、Suzuki Hidefumi、Abe Ryota、Inohara Hidenori、Kaneda Yasufumi、Takahashi Hidehisa、Nimura Keisuke
    • Journal Title

      Cell & Bioscience

      Volume: 12 Issue: 1 Pages: 92-92

    • DOI

      10.1186/s13578-022-00812-8

    • Related Report
      2022 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Peroxisomal membrane protein PMP34 is involved in the human papillomavirus infection pathway.2022

    • Author(s)
      Ito R, Kitamura K, Inohara H, Yusa K, Kaneda Y, Nimura K.
    • Journal Title

      Front Virol.

      Volume: - Pages: 870922-870922

    • DOI

      10.3389/fviro.2022.870922

    • Related Report
      2022 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] LimF is a versatile prenyltransferase for histidine-C-geranylation on diverse non-natural substrates2022

    • Author(s)
      Zhang Yuchen、Hamada Keisuke、Nguyen Dinh Thanh、Inoue Sumika、Satake Masayuki、Kobayashi Shunsuke、Okada Chikako、Ogata Kazuhiro、Okada Masahiro、Sengoku Toru、Goto Yuki、Suga Hiroaki
    • Journal Title

      Nature Catalysis

      Volume: 5 Issue: 8 Pages: 682-693

    • DOI

      10.1038/s41929-022-00822-2

    • Related Report
      2022 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] De Novo Discovery of Thiopeptide Pseudo-natural Products Acting as Potent and Selective TNIK Kinase Inhibitors2022

    • Author(s)
      Vinogradov Alexander A.、Zhang Yue、Hamada Keisuke、Chang Jun Shi、Okada Chikako、Nishimura Hirotaka、Terasaka Naohiro、Goto Yuki、Ogata Kazuhiro、Sengoku Toru、Onaka Hiroyasu、Suga Hiroaki
    • Journal Title

      Journal of the American Chemical Society

      Volume: 144 Issue: 44 Pages: 20332-20341

    • DOI

      10.1021/jacs.2c07937

    • Related Report
      2022 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Structural basis of transcription regulation by CNC family transcription factor, Nrf22022

    • Author(s)
      Sengoku Toru、Shiina Masaaki、Suzuki Kae、Hamada Keisuke、Sato Ko、Uchiyama Akiko、Kobayashi Shunsuke、Oguni Asako、Itaya Hayato、Kasahara Kota、Moriwaki Hirotomo、Watanabe Chiduru、Honma Teruki、Okada Chikako、Baba Shiho、Ohta Tsutomu、Motohashi Hozumi、Yamamoto Masayuki、Ogata Kazuhiro
    • Journal Title

      Nucleic Acids Research

      Volume: 50 Issue: 21 Pages: 12543-12557

    • DOI

      10.1093/nar/gkac1102

    • Related Report
      2022 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Generation and Utilization of a Monoclonal Antibody against Hepatitis B Virus Core Protein for a Comprehensive Interactome Analysis2022

    • Author(s)
      Nakai Yusuke、Miyakawa Kei、Yamaoka Yutaro、Hatayama Yasuyoshi、Nishi Mayuko、Suzuki Hidefumi、Kimura Hirokazu、Takahashi Hidehisa、Kimura Yayoi、Ryo Akihide
    • Journal Title

      Microorganisms

      Volume: 10 Issue: 12 Pages: 2381-2381

    • DOI

      10.3390/microorganisms10122381

    • Related Report
      2022 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Author Correction: Angiotensin II type-1 receptor-associated protein interacts with transferrin receptor-1 and promotes its internalization2022

    • Author(s)
      Abe Eriko、Yamashita Akio、Hirota Keigo、Yamaji Takahiro、Azushima Kengo、Urate Shingo、Suzuki Toru、Tanaka Shohei、Taguchi Shinya、Tsukamoto Shunichiro、Uehara Tatsuki、Wakui Hiromichi、Tamura Kouichi、Takahashi Hidehisa
    • Journal Title

      Scientific Reports

      Volume: 12 Issue: 1 Pages: 17376-17376

    • DOI

      10.1038/s41598-022-25880-1

    • Related Report
      2022 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] PAR3 restricts the expansion of neural precursor cells by regulating hedgehog signaling2022

    • Author(s)
      Hirose T, Sugitani Y, Kurihara H, Kazama H, Kusaka C, Noda T, Takahashi H, Ohno S.
    • Journal Title

      Development.

      Volume: 149 Issue: 21

    • DOI

      10.1242/dev.199931

    • Related Report
      2022 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] The 3′ Pol II pausing at replication-dependent histone genes is regulated by Mediator through Cajal bodies’ association with histone locus bodies2022

    • Author(s)
      Suzuki Hidefumi、Abe Ryota、Shimada Miho、Hirose Tomonori、Hirose Hiroko、Noguchi Keisuke、Ike Yoko、Yasui Nanami、Furugori Kazuki、Yamaguchi Yuki、Toyoda Atsushi、Suzuki Yutaka、Yamamoto Tatsuro、Saitoh Noriko、Sato Shigeo、Tomomori-Sato Chieri、Conaway Ronald C.、Conaway Joan W.、Takahashi Hidehisa
    • Journal Title

      Nature Communications

      Volume: 13 Issue: 1 Pages: 2905-2905

    • DOI

      10.1038/s41467-022-30632-w

    • Related Report
      2022 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Pol Ⅱ動態の新常識―ポージングによる新たな転写制御機構2022

    • Author(s)
      高橋秀尚
    • Journal Title

      実験医学増刊

      Volume: 40 Pages: 1910-1917

    • Related Report
      2022 Annual Research Report
  • [Journal Article] <i>De novo ARF3</i> variants cause neurodevelopmental disorder with brain abnormality2021

    • Author(s)
      Sakamoto M、Sasaki K、Sugie A、Nitta Y、Kimura T、G?rsoy S、Cinleti T、Iai M、Sengoku T、Ogata K、Suzuki A、Okamoto N、Iwama K、Tsuchida N、Uchiyama Y、Koshimizu E、Fujita A、Hamanaka K、Miyatake S、Mizuguchi T、Taguri M、Ito S、Takahashi H、Miyake N、Matsumoto N
    • Journal Title

      Human Molecular Genetics

      Volume: 31 Issue: 1 Pages: 69-81

    • DOI

      10.1093/hmg/ddab224

    • Related Report
      2022 Annual Research Report 2021 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Structural basis of the regulation of the normal and oncogenic methylation of nucleosomal histone H3 Lys36 by NSD22021

    • Author(s)
      Sato Ko、Kumar Amarjeet、Hamada Keisuke、Okada Chikako、Oguni Asako、Machiyama Ayumi、Sakuraba Shun、Nishizawa Tomohiro、Nureki Osamu、Kono Hidetoshi、Ogata Kazuhiro、Sengoku Toru
    • Journal Title

      Nature Communications

      Volume: 12 Issue: 1 Pages: 6605-6605

    • DOI

      10.1038/s41467-021-26913-5

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] An Ultrapotent and Selective Cyclic Peptide Inhibitor of Human β-Factor XIIa in a Cyclotide Scaffold2021

    • Author(s)
      Liu Wenyu、de Veer Simon J.、Huang Yen-Hua、Sengoku Toru、Okada Chikako、Ogata Kazuhiro、Zdenek Christina N.、Fry Bryan G.、Swedberg Joakim E.、Passioura Toby、Craik David J.、Suga Hiroaki
    • Journal Title

      Journal of the American Chemical Society

      Volume: 143 Issue: 44 Pages: 18481-18489

    • DOI

      10.1021/jacs.1c07574

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Pathogenic variants in the survival of motor neurons complex gene GEMIN5 cause cerebellar atrophy2021

    • Author(s)
      Saida Ken et al.
    • Journal Title

      Clinical Genetics

      Volume: 100 Issue: 6 Pages: 722-730

    • DOI

      10.1111/cge.14066

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] The nuclear transcription factor, TAF7, is a cytoplasmic regulator of protein synthesis2021

    • Author(s)
      Cheng Dan、Semmens Kevin、McManus Elizabeth、Chen Qingrong、Meerzaman Daoud、Wang Xiantao、Hafner Markus、Lewis Brian A.、Takahashi Hidehisa、Devaiah Ballachanda N.、Gegonne Anne、Singer Dinah S.
    • Journal Title

      Science Advances

      Volume: 7 Issue: 50

    • DOI

      10.1126/sciadv.abi5751

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] De novo ATP1A3 variants cause polymicrogyria2021

    • Author(s)
      Miyatake Satoko、Kato Mitsuhiro、Kumamoto Takuma、Hirose Tomonori、他
    • Journal Title

      Science Advances

      Volume: 7 Issue: 13 Pages: 2368-2368

    • DOI

      10.1126/sciadv.abd2368

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] メディエーター複合体のコンポーネントMED26による新たな転写制御機構2021

    • Author(s)
      鈴木秀文, 髙橋秀尚
    • Journal Title

      生化学

      Volume: 93 Pages: 810-814

    • Related Report
      2021 Annual Research Report
  • [Presentation] 腫瘍の制御を目指した遺伝子発現制御機構の解明2023

    • Author(s)
      二村圭祐
    • Organizer
      第73回日本電気泳動学会シンポジウム
    • Related Report
      2023 Annual Research Report
    • Invited
  • [Presentation] 多因子間相互作用による遺伝子発現制御機構の解明2023

    • Author(s)
      二村圭祐
    • Organizer
      第96回日本生化学会大会
    • Related Report
      2023 Annual Research Report
    • Invited
  • [Presentation] RNAスプライシング因子が誘発する転写異常による腫瘍増悪化機序2023

    • Author(s)
      二村圭祐
    • Organizer
      第82回日本癌学会学術総会
    • Related Report
      2023 Annual Research Report
  • [Presentation] 生体内における非増殖性センダイウイルスHVJ-Eによる抗腫瘍効果誘導メカニズムの解明2022

    • Author(s)
      二村圭祐
    • Organizer
      日本遺伝子細胞治療学会若手研究セミナー
    • Related Report
      2022 Annual Research Report
  • [Presentation] 多因子間相互作用による遺伝子発現制御機構の解明2022

    • Author(s)
      二村圭祐
    • Organizer
      日本分子生物学会
    • Related Report
      2022 Annual Research Report
    • Invited
  • [Presentation] 生体内における非増殖性ウイルスHVJ-Eによる抗腫瘍効果誘導メカニズムの解明2022

    • Author(s)
      二村圭祐
    • Organizer
      日本遺伝子細胞治療学会
    • Related Report
      2022 Annual Research Report
    • Invited
  • [Presentation] NSD2によるヌクレオソーム上H3 Lys36メチル化の構造基盤2022

    • Author(s)
      仙石 徹
    • Organizer
      日本エピジェネティクス研究会
    • Related Report
      2022 Annual Research Report
  • [Presentation] NSD2/MMSETによるヌクレオソーム上H3K36メチル化とその制御の構造基盤2022

    • Author(s)
      仙石 徹
    • Organizer
      日本生化学会
    • Related Report
      2022 Annual Research Report
    • Invited
  • [Presentation] ヌクレオソーム上H2Bモノユビキチン化の構造基盤2022

    • Author(s)
      大西 修平、内山 琴音、佐藤 光、岡田 千佳子、小林 俊介、西澤 知宏、濡木 理、緒方 一博、仙石 徹
    • Organizer
      日本分子生物学会
    • Related Report
      2022 Annual Research Report
    • Invited
  • [Presentation] Poll Ⅱの一時停止および核体凝集体の制御におけるメディエーター複合体の役割2022

    • Author(s)
      鈴木秀文, 阿部竜太, 嶋田美穂, 廣瀬智威, 廣瀬博子, 野口慶介, 池 陽子, 安井七海, 古郡華月, 山口雄輝, 豊田 敦, 鈴木 穣, 山本達郎, 斉藤典子, Shigeo Sato, Chieri Tomomori-Sato, Ronald C. Conaway, Joan W. Conaway, 高橋秀尚
    • Organizer
      第45回日本分子生物学会年会
    • Related Report
      2022 Annual Research Report
    • Invited
  • [Presentation] メディエーター複合体による新規の転写スピード調節機構の解明2022

    • Author(s)
      鈴木秀文, 阿部竜太, 嶋田美穂, 廣瀬智威, 廣瀬博子, 野口慶介, 古郡華月, 池 陽子, 安井七海, 山口雄輝, 豊田 敦, 鈴木 穣, 山本達郎, 斉藤典子, Ronald C. Conaway, Joan W. Conaway, 高橋 秀尚
    • Organizer
      第45回日本分子生物学会年会
    • Related Report
      2022 Annual Research Report
    • Invited
  • [Presentation] 新規のin situビオチン標識法を用いたCajal body構成因子のマルチオミクス解析2022

    • Author(s)
      野口慶介, 鈴木秀文, 阿部竜太, 堀内恵子, 秋山智彦, 池 陽子, 井野陽子, 木村弥生, 梁 明秀,山口雄輝, 高橋秀尚
    • Organizer
      日本プロテオーム学会2022年大会
    • Related Report
      2022 Annual Research Report
    • Invited
  • [Presentation] 新規ビオチン標識法を用いたマルチオミックス解析によるCajal body構成因子の網羅的解析とCajal body形成メカニズムの解明2022

    • Author(s)
      野口慶介, 鈴木秀文, 阿部竜太, 池 陽子, 井野洋子, 木村弥生, 梁 明秀, 土井 宏, 田中章景, 山口雄輝, 高橋秀尚
    • Organizer
      第45回日本分子生物学会年会
    • Related Report
      2022 Annual Research Report
    • Invited
  • [Presentation] 大脳発生過程においてPAR3はヘッジホッグ・シグナリングの制御を介して神経前駆細胞の増殖に制限をかける2022

    • Author(s)
      廣瀬智威, 杉谷善信, 栗原秀剛, 風間宏美, 日下智保, 野田哲生, 髙橋秀尚, 大野茂男
    • Organizer
      第45回日本分子生物学会年会
    • Related Report
      2022 Annual Research Report
  • [Presentation] Interaction of major and minor spliceosomes in regulating splicing of U12-type introns2022

    • Author(s)
      堀内恵子, 高橋秀尚, Juan Valcrcel
    • Organizer
      第45回日本分子生物学会年会
    • Related Report
      2022 Annual Research Report
  • [Presentation] LECのコンポーネントZC3H8による転写終結制御機構の解明2022

    • Author(s)
      鬼澤理紗, 野口慶介, 仙石 徹, 緒方一博, 鈴木秀文, 高橋秀尚
    • Organizer
      第45回日本分子生物学会年会
    • Related Report
      2022 Annual Research Report
  • [Presentation] メディエーター複合体の核内凝集体における転写制御機構の解析2022

    • Author(s)
      馬目博志, 鈴木秀文, 高橋秀尚
    • Organizer
      第45回日本分子生物学会年会
    • Related Report
      2022 Annual Research Report
  • [Presentation] 7SK snRNAによるp-TEFb局在化阻害によるsnRNA遺伝子の転写終結制御2022

    • Author(s)
      小川真太郎, 鈴木秀文, 高橋秀尚
    • Organizer
      第45回日本分子生物学会年会
    • Related Report
      2022 Annual Research Report
  • [Presentation] 転写バーストにおけるTFIIDのサブユニットTAF7の機能解明2022

    • Author(s)
      古郡華月, 鈴木秀文, 阿部竜太, 高橋秀尚
    • Organizer
      第45回日本分子生物学会年会
    • Related Report
      2022 Annual Research Report
  • [Presentation] LECのコンポーネントICE2による転写終結制御機構の解明2022

    • Author(s)
      寺内佑希, 仙石 徹, 緒方一博, 鈴木秀文, 小川真太郎, 高橋秀尚
    • Organizer
      第45回日本分子生物学会年会
    • Related Report
      2022 Annual Research Report
  • [Presentation] Elucidation of the dynamics of anti-tumor immunity induced in vivo2021

    • Author(s)
      二村圭祐
    • Organizer
      日本生化学会年会
    • Related Report
      2021 Annual Research Report
    • Invited
  • [Presentation] 腫瘍を増悪化するRNAスプライシング制御因子SF3B2による転写制御2021

    • Author(s)
      二村圭祐
    • Organizer
      日本分子生物学会年会
    • Related Report
      2021 Annual Research Report
    • Invited
  • [Presentation] メディエーター複合体による新規の3’PolⅡポージング制御機構の解明2021

    • Author(s)
      鈴木 秀文, 阿部 竜太, 嶋田 美穂, 廣瀬 智威, 廣瀬 博子, 野口 慶介, 古郡 華月, 池 陽子, 安井 七海, 山口 雄輝, 豊田 敦, 鈴木 穣, 山本 達郎, 斉藤 典子, Ronald C. Conaway, Joan W. Conaway, 高橋 秀尚
    • Organizer
      日本分子生物学会年会
    • Related Report
      2021 Annual Research Report
    • Invited
  • [Presentation] 新規ビオチン標識法を用いたマルチオミックス解析によるCajal body形成メカニズムの解明2021

    • Author(s)
      野口 慶介,鈴木 秀文,阿部 竜太,池 陽子,井野 洋子,木村 弥生,梁 明秀,土井 宏,田中 章景,山口 雄輝,高橋 秀尚
    • Organizer
      日本分子生物学会年会
    • Related Report
      2021 Annual Research Report
  • [Presentation] TFIIDのサブユニットTAF7によるPol Ⅱの一時停止→転写バースト機構の解明2021

    • Author(s)
      古郡 華月,鈴木 秀文,松村 健,阿部 竜太,高橋 秀尚
    • Organizer
      日本分子生物学会年会
    • Related Report
      2021 Annual Research Report
  • [Presentation] CDK11は2つの核内凝集体において複製依存性ヒストン遺伝子の転写終結を制御する2021

    • Author(s)
      澁谷 智花,古郡 華月,鈴木 秀文,高橋 秀尚
    • Organizer
      日本分子生物学会年会
    • Related Report
      2021 Annual Research Report
  • [Presentation] NSD2によるヌクレオソーム上H3 Lys36メチル化の構造基盤2021

    • Author(s)
      佐藤 光、Amarjeet Kumar、濱田 恵輔、岡田 千佳子、小國 麻子、町山 歩、櫻庭 俊、西澤 知宏、濡木 理、河野 秀俊、緒方 一博、仙石 徹
    • Organizer
      日本分子生物学会年会
    • Related Report
      2021 Annual Research Report
    • Invited
  • [Presentation] AlphaFoldの医学・生物学・工学研究への応用2021

    • Author(s)
      仙石 徹
    • Organizer
      日本分子生物学会年会
    • Related Report
      2021 Annual Research Report
  • [Remarks] 転写ユニティー領域のホームページ

    • URL

      https://www.med.osaka-u.ac.jp/pub/gts/TranscriptionUnity/

    • Related Report
      2022 Annual Research Report
  • [Remarks] 転写ユニティーホームページ

    • URL

      https://www.med.osaka-u.ac.jp/pub/gts/TranscriptionUnity/

    • Related Report
      2021 Annual Research Report
  • [Patent(Industrial Property Rights)] 生体試料中の多因子間相互作用を同定する方法およびキット2022

    • Inventor(s)
      二村圭祐
    • Industrial Property Rights Holder
      二村圭祐
    • Industrial Property Rights Type
      特許
    • Industrial Property Number
      2022-068519
    • Filing Date
      2022
    • Related Report
      2022 Annual Research Report
    • Overseas

URL: 

Published: 2021-10-22   Modified: 2025-01-30  

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