Generation of Neural Diversity and Neocortex

• Project Area: Neural Diversity and Neocortical Organization
• Project/Area Number: 22123001
• Research Category: Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)
• Allocation Type: Single-year Grants
• Review Section: Biological Sciences
• Research Institution: Institute of Physical and Chemical Research (2014-2015); National Institute for Basic Biology (2010-2013)
• Principal Investigator: Yamamori Tetsuo 国立研究開発法人理化学研究所, 脳科学総合研究センター, チームリーダー (80260206)
• Co-Investigator(Kenkyū-buntansha): 影山 龍一郎 京都大学, ウイルス研究所, 教授 (80224369) ; 後藤 由季子 東京大学, 薬学研究科, 教授 (70252525) ; 島崎 琢也 慶應義塾大学, 医学部, 准教授 (00324749) ; 野田 亮 京都大学, 医学研究科, 教授 (30146708) ; 桝 正幸 筑波大学, 医学医療系, 教授 (20243032) ; 大隅 典子 東北大学, 医学研究科, 教授 (00220343) ; 三品 昌美 立命館大学, 総合科学技術研究機構, 教授 (80144351) ; 森 郁恵 名古屋大学, 理学研究科, 教授 (90219999)
• Project Period (FY): 2010-04-01 – 2016-03-31
• Project Status: Completed (Fiscal Year 2015)
• Budget Amount: ¥45,370,000 (Direct Cost: ¥34,900,000、Indirect Cost: ¥10,470,000); Fiscal Year 2015: ¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000); Fiscal Year 2014: ¥6,760,000 (Direct Cost: ¥5,200,000、Indirect Cost: ¥1,560,000); Fiscal Year 2013: ¥7,150,000 (Direct Cost: ¥5,500,000、Indirect Cost: ¥1,650,000); Fiscal Year 2012: ¥10,010,000 (Direct Cost: ¥7,700,000、Indirect Cost: ¥2,310,000); Fiscal Year 2011: ¥7,410,000 (Direct Cost: ¥5,700,000、Indirect Cost: ¥1,710,000); Fiscal Year 2010: ¥10,140,000 (Direct Cost: ¥7,800,000、Indirect Cost: ¥2,340,000)
• Keywords: 大脳新皮質 / 領野 / 層 / 神経幹細胞 / 神経投射 / 大脳皮質 / 時系列制御 / 神経細胞多様性 / 神経科学 / 神経細胞 / 多様性 / 層形成 / 領野形成 / 層構造 / 大脳皮質領野 / 神経結合

Outline of Final Research Achievements

The neocortex is formed as the six layers that are sequentially generated in the order so that newly synthesized layer neurons get over the older layer cells (in-side-out fashion). The neocortical cells also are formed as so called "areas" that are divided into some of 50 different parts of the neocortex. Each area is defined as a functional unit which is originally distinguished by cytoarchetechnotic differences. It is thought that understanding the formation of the layers and areas can contribute to understanding the basic principle underlying the function of the neocortex. We therefore organized a group grant that is specifically focused on the formation and the functional organization of the neocortex. This group started in 2010 for five years and achieved a significant contribution to the field not only in Japan but also internationally.

Research Products

• [Journal Article] Expression pattern of immediate early genes in the cerebellum of D1R KO, D2R KO, and wild type mice under vestibular-controlled activity (2015)
  • Author(s): Nakamura T, Sato A, Kitsukawa T, Sasaoka T, Yamamori T.
  • Journal Title: Front Cell Dev Biol. Volume: 3 Pages: 1-15
  • DOI: 10.3389/fcell.2015.00038
  • Peer Reviewed / Open Access
• [Journal Article] Expression pattern of immediate early genes in the cerebellum of D1R KO, D2R KO, and wild type mice under vestibular-controlled activity. (2015)
  • Author(s): Sadakane O, Watakabe A, Ohtsuka M, Takaji M, Sasaki T, Kasai M, Isa T, Kato G, Nabekura J, Mizukami H, Ozawa K, Kawasaki H, Yamamori T.
  • Journal Title: eNeuro. Volume: 2 Pages: 4-4
  • Peer Reviewed / Open Access
• [Journal Article] Long-term two-photon calcium imaging of neuronal populations with subcellular resolution in adult non-human primates. (2015)
  • Author(s): Sadakane O., Masamizu Y., Watakabe A., Terada S., Ohtsuka M., Takaji M., Mizukami H., Ozawa K., Kawasaki H., Matsuzaki M., Yamamori T.
  • Journal Title: Cell Reports Volume: 13 Issue: 9 Pages: 1989-1999
  • DOI: 10.1016/j.celrep.2015.10.050
  • NAID: 120005829368
  • Peer Reviewed / Open Access
• [Presentation] The function and the regulation of the genes selectively expressed in the primate neocortex. (2015)
  • Author(s): Yamamori, T
  • Organizer: 中国神経科学会
  • Place of Presentation: Wuzhen , China
  • Year and Date: 2015-09-23
  • Int'l Joint Research / Invited
• [Presentation] The ocular dominance column and gene expression in the marmoset primary visual cortex (2013)
  • Author(s): Tetsuo Yamamori
  • Organizer: Neuro2013 Satellite Symposium "Molecular & Cellular Mechanisms of Brain Development & Evolution"
  • Place of Presentation: 京都府立医科大学図書館ホール（京都府）
• [Presentation] Genes selectively expressed in regions of primate neocortex : the functions and implication for cortical specialization (2012)
  • Author(s): Tetsuo Yamamori
  • Organizer: International Symposium "Neocortical Organization"
  • Place of Presentation: 岡崎コンファレンスセンター(愛知県)
  • Year and Date: 2012-03-13
• [Remarks] 新学術領域「大脳新皮質構築」
  • URL: http://www.md.tsukuba.ac.jp/neocortex/
• [Remarks] 新学術領域研究「神経細胞の多様性と大脳新皮質の構築」
  • URL: http://www.md.tsukuba.ac.jp/neocortex/
• [Remarks] 新学術領域研究「神経細胞の多様性と大脳新皮質の構築」
  • URL: http://www.md.tsukuba.ac.jp/neocortex/
• [Remarks] 新学術領域研究「神経細胞の多様性と大脳新皮質の構築」
  • URL: http://www.md.tsukuba.ac.jp/neocortex/
• [Remarks]
  • URL: http://www.md.tsukuba.ac.jp/neocortex/
• [Funded Workshop] Neocortical Organization 3 (2016)
  • Place of Presentation: Koshiba Hall, University of Tokyo（Tokyo)
  • Year and Date: 2016-02-10
• [Funded Workshop] Neocortical Organization III (2016)
  • Place of Presentation: Koshiba Hall, University of Tokyo（Tokyo)
  • Year and Date: 2016-02-10