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"Molecular mechanisms for establishment of sex differences"

Administrative Group

Project AreaMolecular mechanisms for establishment of sex differences.
Project/Area Number 22132001
Research Category

Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)

Allocation TypeSingle-year Grants
Review Section Biological Sciences
Research InstitutionKyushu University

Principal Investigator

MOROHASHI Ken-ichirou  九州大学, 医学(系)研究科(研究院), 主幹教授 (30183114)

Co-Investigator(Kenkyū-buntansha) OGATA Tsutomu  浜松医科大学, 医学部, 教授 (40169173)
YAMADA Gen  和歌山県立医科大学, 先端医学研究所, 教授 (80174712)
TANAKA Minoru  基礎生物学研究所, 生殖遺伝学研究室, 准教授 (80202175)
Co-Investigator(Renkei-kenkyūsha) ITO Michihiko  北里大学, 理学部, 准教授 (90240994)
SUYAMA Mikita  九州大学, 大学院医学研究院, 教授 (70452365)
TAKEYAMA Kenichi  東京大学, 分子細胞生物学研究所, 准教授 (30323570)
TSUTSUI Kazuyoshi  早稲田大学, 教育・総合科学学術院, 教授 (20163842)
NAGAHAMA Yoshitaka  愛媛大学, 社会連携推進機構, 教授 (50113428)
KATO Shigeaki  東京大学, 分子細胞生物学研究所, 教授 (60204468)
SUGINO Norihiro  山口大学, 大学院医学系研究科, 教授 (10263782)
YOSHIDA Shosei  基礎生物学研究所, 生殖細胞研究部門, 教授 (60294138)
Project Period (FY) 2010-04-01 – 2015-03-31
Project Status Completed (Fiscal Year 2014)
Budget Amount *help
¥37,830,000 (Direct Cost: ¥29,100,000、Indirect Cost: ¥8,730,000)
Fiscal Year 2014: ¥7,800,000 (Direct Cost: ¥6,000,000、Indirect Cost: ¥1,800,000)
Fiscal Year 2013: ¥6,240,000 (Direct Cost: ¥4,800,000、Indirect Cost: ¥1,440,000)
Fiscal Year 2012: ¥8,580,000 (Direct Cost: ¥6,600,000、Indirect Cost: ¥1,980,000)
Fiscal Year 2011: ¥6,500,000 (Direct Cost: ¥5,000,000、Indirect Cost: ¥1,500,000)
Fiscal Year 2010: ¥8,710,000 (Direct Cost: ¥6,700,000、Indirect Cost: ¥2,010,000)
Keywords遺伝子 / 細胞・組織 / 脳・神経 / 発生・分化 / 臨床 / 性差 / 若手支援 / 次世代シークエンサー / 共同研究 / 領域会議 / 市民公開シンポジウム / 技術支援 / 広報 / ホームページ / 実験動物
Outline of Final Research Achievements

General affairs of the research group, ‘Molecular Mechanisms of Sex Differences’, have made efforts to support the research group to achieve their aims and distribute the outcomes widely to the public. Thus, we disposed persons in charge of ‘meetings’, ‘supports of young scientists’, ‘publicity’, ‘evaluation’, ‘experimental technics’ and ‘experimental animals’. The persons in charge of ‘meetings’, ‘supports of young scientists,’ and ‘evaluation’ evaluated our research progress and promoted collaborations through holding meetings of this grant group and those planed by young scientists. The persons in charge of ‘publicity’ distributed the research outcomes through the home page. Also, lectures open to the public were hold. The persons in charge of ‘experimental technics’ and ‘experimental animals’ supported the members of this grant group through analysis with next generation sequencer and genetically modified animals.

Report

(6 results)
  • 2014 Annual Research Report   Final Research Report ( PDF )
  • 2013 Annual Research Report
  • 2012 Annual Research Report
  • 2011 Annual Research Report
  • 2010 Annual Research Report
  • Research Products

    (24 results)

All 2013 2012 2011 2010 Other

All Journal Article (8 results) (of which Peer Reviewed: 8 results) Presentation (12 results) (of which Invited: 5 results) Remarks (4 results)

  • [Journal Article] Contribution of Leydig and Sertoli cells to testosterone production in mouse fetal testes2013

    • Author(s)
      Yuichi Shima
    • Journal Title

      Molecular Endocrinology

      Volume: 27 Issue: 1 Pages: 63-73

    • DOI

      10.1210/me.2012-1256

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Hyperproliferation of mitotically active germ cells dues todefective anti-M#252;llerian hormone signaling mediates sex reversal in medaka.2012

    • Author(s)
      Nakamura, S
    • Journal Title

      Development

      Volume: 139 Issue: 13 Pages: 2283-2287

    • DOI

      10.1242/dev.076307

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Relative frequency of underlying genetic causes for the development of UPD(14)pat-like phenotype2012

    • Author(s)
      Kagami M, Ogata T, et al
    • Journal Title

      Eur J Hum Genet

      Volume: (accepted)(Epub ahead of print) Issue: 9 Pages: 928-932

    • DOI

      10.1038/ejhg.2012.26

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Cbx2, a polycomb group gene, is required for Sry gene expression in mice.2012

    • Author(s)
      Katoh-Fukui Y, Miyabayashi K, Komatsu T, Owaki A, Baba T., Shima, Y, Kidokoro T, Kanai Y, Schedl A, Wilhelm D, Koopman P, Okuno Y, Morohashi K.
    • Journal Title

      Endocrinology

      Volume: 153(2) Issue: 2 Pages: 913-924

    • DOI

      10.1210/en.2011-1055

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Identification of enhancer specific for fetal Leydig cells in Ad4BP/SF-1 gene2011

    • Author(s)
      Yuichi Shima, et al
    • Journal Title

      Endocrinology

      Volume: 153 Issue: 1 Pages: 417-425

    • DOI

      10.1210/en.2011-1407

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Abnormal epithelial cell polarity and migration of Emx2 KO embryonic gonads induced by ectopic EGFR expression.2010

    • Author(s)
      M.Kusaka, et al.
    • Journal Title

      Endocrinology

      Volume: 151 Pages: 5893-5904

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] The IG-DMR and the MEG3-DMR at human chromosome 14q32.2: hierarchical interaction and distinct functional properties as imprinting control centers.2010

    • Author(s)
      Kagami, M., et al.
    • Journal Title

      PLoS Genet

      Volume: 6

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Identification of germline stem cells in the ovary of teleost medaka.2010

    • Author(s)
      Nakamura, S., et al.
    • Journal Title

      Science

      Volume: 328 Pages: 1561-1563

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Presentation] 哺乳類の性分化・性成熟の新知見:性腺機能を制御する遺伝子ネットワークとその破綻による疾患:バックドア経路:テストステロンを経由しないジヒドロテストステロン産生経路2012

    • Author(s)
      緒方 勤
    • Organizer
      第35回日本分子生物学会学術集会ワークショップ
    • Place of Presentation
      福岡
    • Year and Date
      2012-12-11
    • Related Report
      2012 Annual Research Report
    • Invited
  • [Presentation] Developmental program for urogenital/reproductive organ formation2012

    • Author(s)
      Gen Yamada
    • Organizer
      International Anatomical Sciences and Cell Biology Conference (IASCBC 2012)
    • Place of Presentation
      Thailand
    • Year and Date
      2012-12-06
    • Related Report
      2012 Annual Research Report
    • Invited
  • [Presentation] 性差形成と維持の機構2012

    • Author(s)
      諸橋 憲一郎
    • Organizer
      第44回日本動脈硬化学会
    • Place of Presentation
      福岡
    • Year and Date
      2012-07-19
    • Related Report
      2012 Annual Research Report
    • Invited
  • [Presentation] Glycolytic genes as the targets of Ad4BP/SF-12012

    • Author(s)
      Ken Morohashi
    • Organizer
      15th Conference on the adrenal cortex, Adrenal 2012,
    • Place of Presentation
      Texas
    • Year and Date
      2012-06-19
    • Related Report
      2012 Annual Research Report
    • Invited
  • [Presentation] 胎仔ライディッヒ細胞と成獣ライディッヒ細胞の異質性について2012

    • Author(s)
      諸橋 憲一郎
    • Organizer
      第85回日本内分泌学会
    • Place of Presentation
      名古屋
    • Year and Date
      2012-04-19
    • Related Report
      2012 Annual Research Report
    • Invited
  • [Presentation] 生殖腺の性差構築2011

    • Author(s)
      諸橋憲一郎
    • Organizer
      第4回 日本性差医学・医療学会
    • Place of Presentation
      下関
    • Related Report
      2010 Annual Research Report
  • [Presentation] Molecular and Cellular Mechanisms of Testis Differentiation2010

    • Author(s)
      Morohashi K
    • Organizer
      Gordon Research Conference, 2010 Reproductive Tract Biology
    • Place of Presentation
      New Hampshire, USA
    • Related Report
      2010 Annual Research Report
  • [Presentation] Common Steroidogenic Primordia in Gonadal and Adrenal Morphogenesis Lineage of Testicular Leydig cells and Adrenal Cortex2010

    • Author(s)
      Morohashi K, et al.
    • Organizer
      43 rd Annual Meeting of the Society for the Study of Reproduction
    • Place of Presentation
      Milwaukee, USA
    • Related Report
      2010 Annual Research Report
  • [Presentation] Ad4BP/SF-1 as the key factor for steroidogenic cell development2010

    • Author(s)
      Morohashi K
    • Organizer
      14th Adrenal Cortex Conference
    • Place of Presentation
      San Diego, USA
    • Related Report
      2010 Annual Research Report
  • [Presentation] ステロイド産生細胞の発生2010

    • Author(s)
      諸橋憲一郎
    • Organizer
      第28回内分泌代謝サマーセミナー
    • Place of Presentation
      長崎
    • Related Report
      2010 Annual Research Report
  • [Presentation] Transcriptomic analysis of fetal Leydig cells2010

    • Author(s)
      嶋雄一、諸橋憲一郎, 他
    • Organizer
      第33回 日本分子生物学会、第83回 日本生化学会
    • Place of Presentation
      神戸
    • Related Report
      2010 Annual Research Report
  • [Presentation] Expression profile of steroidogenic genes in the fetal LEydig cells2010

    • Author(s)
      宮林香奈子、諸橋憲一郎, 他
    • Organizer
      第33回 日本分子生物学会、第83回 日本生化学会
    • Place of Presentation
      神戸
    • Related Report
      2010 Annual Research Report
  • [Remarks] 平成22~平成26年度 文部科学省科学研究費補助金 新学術領域研究「性差構築の分子基盤」

    • Related Report
      2014 Annual Research Report
  • [Remarks] 領域ホームページ

    • URL

      http://www.seisa.med.kyushu-u.ac.jp/index.html

    • Related Report
      2012 Annual Research Report
  • [Remarks]

    • URL

      http://www.seisa.med.kyushu-u.ac.jp/

    • Related Report
      2011 Annual Research Report
  • [Remarks]

    • URL

      http://www.seisa.med.kyushu-u.ac.jp/

    • Related Report
      2010 Annual Research Report

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Published: 2010-08-23   Modified: 2019-07-29  

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