Establishment of Integrative Multi-level Systems Biology and its Applications

• Project Area: Establishment of Integrative Multi-level Systems Biology and its Applications
• Project/Area Number: 22136001
• Research Category: Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)
• Allocation Type: Single-year Grants
• Review Section: Complex systems
• Research Institution: Osaka University
• Principal Investigator: KURACHI YOSHIHISA 大阪大学, 医学(系)研究科(研究院), 教授 (30142011)
• Co-Investigator(Kenkyū-buntansha): INOUE Ryuji 福岡大学, 医学部, 教授 (30232573) ; YAMASHITA Fumiyoshi 京都大学, 薬学研究科(研究院), 准教授 (30243041) ; SUZUKI Hiroshi 東京大学, 医学部附属病院, 教授 (80206523) ; KITANO Hiroaki 沖縄科学技術大学院大学, その他の研究科, 教授 (80500256) ; OHTSUKI Sumio 熊本大学, 大学院生命科学研究部, 教授 (60323036)
• Co-Investigator(Renkei-kenkyūsha): AMANO Akira 立命館大学, 生命科学部, 教授 (60252491) ; KINOSHITA Kengo 東北大学, 大学院情報科学研究科, 教授 (60332293) ; HARI Yoshiyuki 大阪大学, 大学院薬学系研究科, 准教授 (50347423) ; MAKITA Naomasa 長崎大学, 大学院医歯薬学総合研究科, 教授 (00312356) ; ISHIKAWA Yoshihiro 横浜市立大学, 大学院医学系研究科, 教授 (40305470) ; HONJO Haruo 名古屋大学, 環境医学研究所, 准教授 (70262912) ; NAKAZAWA Kazuo 独立行政法人国立循環器秒研究センター, 研究情報基盤管理室, 室長 (50198058) ; OKUNO Yasushi 京都大学, 大学院医学研究科, 教授 (20283666) ; KUSUHARA Hiroyuki 東京大学, 大学院薬学系研究科, 教授 (00302612) ; KAGECHIKA Hiroyuki 東京医科歯科大学, 生体材料工学研究所, 教授 (20177348)
• Project Period (FY): 2010-04-01 – 2016-03-31
• Project Status: Completed (Fiscal Year 2015)
• Budget Amount: ¥64,220,000 (Direct Cost: ¥49,400,000、Indirect Cost: ¥14,820,000); Fiscal Year 2015: ¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000); Fiscal Year 2014: ¥14,040,000 (Direct Cost: ¥10,800,000、Indirect Cost: ¥3,240,000); Fiscal Year 2013: ¥12,220,000 (Direct Cost: ¥9,400,000、Indirect Cost: ¥2,820,000); Fiscal Year 2012: ¥14,950,000 (Direct Cost: ¥11,500,000、Indirect Cost: ¥3,450,000); Fiscal Year 2011: ¥12,610,000 (Direct Cost: ¥9,700,000、Indirect Cost: ¥2,910,000); Fiscal Year 2010: ¥6,500,000 (Direct Cost: ¥5,000,000、Indirect Cost: ¥1,500,000)
• Keywords: システム生物学 / 生理学 / 生物物理学 / 心臓 / 不整脈 / 薬物動態 / 全身循環 / 代謝 / 薬物動態学 / 生物物理 / 生物学

Outline of Annual Research Achievements

本年度は、前年度までの5年間（平成22年度から平成26年度）に実施された新学術領域研究「統合的多階層生体機能学領域の確立とその応用」（以下、領域）の成果の取りまとめをおこなった。
本領域を構成した全ての計画研究、公募研究の研究成果を総括し、研究項目毎、そして領域としての学術的成果を纏めた。また、関連学会や社会への影響を整理した。さらに、成果取りまとめ状況、学際的共同研究の実施状況、研究費の使用状況、若手研究者の育成状況を調査し、総括班で自己評価を行った。その結果、当該領域は申請時に計画した到達目標を完全に達成したという結論に達した。また、外部評価委員による書面審査、ヒアリング審査に対応する準備のため、総括班メンバーで会議を行った。研究代表者を中心にそれらの審査に臨んだ結果、「A（研究領域の設定目標に照らして、期待通りの成果があった）」との最終評価を頂いた。
本年度も、領域研究期間に上がった成果を報告するため、班員のシンポジウム開催などの支援を行った。
冊子体の研究成果報告書を作成し、日本学術振興会への提出、関係・関連研究者、研究機関への配布のための準備を行った。
本領域に関わった研究者は本領域が開拓した研究分野の重要性を認識している。最終評価においても、新しい学理を生み出すような研究成果が期待として述べられている。今後この分野をさらに発展させるために必要な研究、取り得る方法に関して、領域外の研究者も交えて議論を行った。

Research Progress Status

27年度が最終年度であるため、記入しない。

Strategy for Future Research Activity

27年度が最終年度であるため、記入しない。

Research Products

• [Journal Article] Multilevel modeling of physiological systems on PhysioDesigner (2016)
  • Author(s): 浅井義之, 安部武志, 北野宏明.
  • Journal Title: Folia Pharmacologica Japonica Volume: 147 Issue: 2 Pages: 114-119
  • DOI: 10.1254/fpj.147.114
  • NAID: 130005125655
  • ISSN: 0015-5691, 1347-8397
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Versatile Modeling Platform for Multilevel Hybrid Modeling of Physiological Systems (2016)
  • Author(s): 浅井義之, 安部武志, 北野宏明.
  • Journal Title: Seibutsu Butsuri Volume: 56 Issue: 2 Pages: 120-124
  • DOI: 10.2142/biophys.56.120
  • NAID: 130005140945
  • ISSN: 0582-4052, 1347-4219
  • Peer Reviewed
• [Journal Article] Network analyses based on comprehensive molecular interaction maps reveal robust control structures in yeast stress response pathways (2016)
  • Author(s): Eiryo Kawakami, Vivek K Singh, Kazuko Matsubara, Takashi Ishii, Yukiko Matsuoka, Takeshi Hase,Priya Kulkarni, Kenaz Siddiqui, Janhavi Kodilkar, Nitisha Danve, Indhupriya Subramanian, Manami Katoh, Yuki Shimizu-Yoshida, Samik Ghosh, Abhay Jere & Hiroaki Kitano
  • Journal Title: npj Systems Biology and Applications Volume: 2 Issue: 1 Pages: 15018-15018
  • DOI: 10.1038/npjsba.2015.18
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Artificial Intelligence to Win the Novel Prize and Beyond: Creating the Engine for Scientific Discovery. (2016)
  • Author(s): Kitano H.
  • Journal Title: AI magazine Volume: 37(1) Pages: 39-49
  • Peer Reviewed
• [Journal Article] 人工知能がノーベル賞を獲る日, そして人類の未来－究極のグランドチャレンジがもたらすもの－. (2016)
  • Author(s): 北野宏明.
  • Journal Title: 人工知能学会誌 Volume: 31(2) Pages: 275-286
  • Peer Reviewed
• [Journal Article] Optical control of neuronal firing via photo-induced electron transfer in donor-acceptor conjugates. (2016)
  • Author(s): Yuta Takano, Tomohiro Numata, Kazuto Fujishima, Kazuaki Miyake, Kazuya Nakao, Wesley David Grove, Ryuji Inoue, Mineko Kengaku, Shigeyoshi Sakaki, Yasuo Mori, Tatsuya Murakami, Hiroshi Imahori.
  • Journal Title: Chemical Science Volume: 印刷中
  • NAID: 120005841415
  • Peer Reviewed
• [Journal Article] Distinct pharmacological and molecular properties of the acid-sensitive outwardly rectifying (ASOR) anion channel from those of the volume-sensitive outwardly rectifying (VSOR) anion channel. (2016)
  • Author(s): Kaori Sato-Numata, Tomohiro Numata, Ryuji Inoue, Yasunobu Okada.
  • Journal Title: Pflugers Archiv Euorpean Journal of Physiology Volume: 印刷中
  • Peer Reviewed
• [Journal Article] Screening of Transient Receptor Potential Canonical Channel Activators Identifies Novel Neurotrophic Piperazine Compounds (2016)
  • Author(s): S. Sawamura, M. Hatano, Y. Takada, K. Hino, T. Kawamura, J. Tanikawa, H. Nakagawa, H. Hase, A. Nakao, M. Hirano, R. Rotrattanadumrong, S. Kiyonaka, M.X. Mori, M. Nishida, Y. Hu, R. Inoue, R. Nagata and Y. Mori
  • Journal Title: Mol Pharmacol Volume: 89(3) Issue: 3 Pages: 348-363
  • DOI: 10.1124/mol.115.102863
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Halogenated hydrocarbon solvent-related cholangiocarcinoma risk: biliary excretion of glutathione conjugates of 1,2-dichloropropane evidenced by untargeted metabolomics analysis. (2016)
  • Author(s): Yu Toyoda, Tappei Takada, Hiroshi Suzuki.
  • Journal Title: Sci Rep Volume: 印刷中
  • Peer Reviewed / Open Access
• [Journal Article] Mechanism analyses and mechanism-based prediction for adverse drug reactions using systems pharmacology (2016)
  • Author(s): Kariya Y, Honma M, Suzuki H.
  • Journal Title: Folia Pharmacologica Japonica Volume: 147 Issue: 2 Pages: 89-94
  • DOI: 10.1254/fpj.147.89
  • NAID: 130005125653
  • ISSN: 0015-5691, 1347-8397
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Novel dysfunctional variant in ABCG2 as a cause of severe tophaceous gout: biochemical, molecular genetic and functional analysis. (2016)
  • Author(s): Blanka Stiburkova, Hiroshi Miyata, Jakub Zavada, Michal Tomcik, Karel Pavelka, Gabriela Storkanova, Yu Toyoda, Tappei Takada, and Hiroshi Suzuki.
  • Journal Title: Rheumatology Volume: 55(1) Issue: 1 Pages: 191-194
  • DOI: 10.1093/rheumatology/kev350
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Modeling and simulation of pharmacokinetic drug-drug interaction caused by induction of metabolic enzymes (2016)
  • Author(s): 山下富義
  • Journal Title: Folia Pharmacologica Japonica Volume: 147 Issue: 2 Pages: 95-100
  • DOI: 10.1254/fpj.147.95
  • NAID: 130005125654
  • ISSN: 0015-5691, 1347-8397
  • Peer Reviewed
• [Journal Article] An Epithelial Ca2+-Sensor Protein is an Alternative to Calmodulin to Compose Functional KCNQ1 Channels. (2015)
  • Author(s): Inanobe A, Tsuzuki C, Kurachi Y.
  • Journal Title: Cell Physiol Biochem Volume: 36 Issue: 5 Pages: 1847-1861
  • DOI: 10.1159/000430155
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] A Novel Conduction Mechanism Linking Cardiac Action Potentials and Excitation Propagation:Electric Field Mechanism (2015)
  • Author(s): 津元国親, 倉智嘉久.
  • Journal Title: Transactions of Japanese Society for Medical and Biological Engineering Volume: 53 Issue: 3 Pages: 138-143
  • DOI: 10.11239/jsmbe.53.138
  • NAID: 130005106898
  • ISSN: 1347-443X, 1881-4379
  • Acknowledgement Compliant
• [Journal Article] Databases for multilevel biophysiology research available at Physiome.jp. (2015)
  • Author(s): Asai Yoshiyuki, Abe Takeshi, Li Li, Oka Hideki, Nomura Taishin, Kitano Hiroaki.
  • Journal Title: Frontiers in Physiology Volume: 6(251) Pages: 1-11
  • DOI: 10.3389/fphys.2015.00251
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Software Platform for Multilevel Modeling of Physiological Systems (2015)
  • Author(s): 浅井義之, 安部武志, 野村泰伸, 北野宏明.
  • Journal Title: Transactions of Japanese Society for Medical and Biological Engineering Volume: 53 Issue: 3 Pages: 144-150
  • DOI: 10.11239/jsmbe.53.144
  • NAID: 130005106899
  • ISSN: 1347-443X, 1881-4379
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] VISIONET: intuitive visualisation of overlapping transcription factor networks, with applications in cardiogenic gene discovery. (2015)
  • Author(s): Hieu T Nim, Milena B Furtado, Mauro W Costa, Nadia A Rosenthal, Hiroaki Kitano, Sarah E Boyd.
  • Journal Title: BMC Bioinformatics Volume: 16 Issue: 1 Pages: 141-141
  • DOI: 10.1186/s12859-015-0578-0
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] システム・トキシコロジーの展開. (2015)
  • Author(s): 北野宏明.
  • Journal Title: QIAGEN eyes Volume: 12 Pages: 7-9
• [Journal Article] Identifying problematic drugs based on the characteristics of their targets. (2015)
  • Author(s): Tiago J. S. Lopes, Jason E. Shoemaker, Yukiko Matsuoka, Yoshihiro Kawaoka, Hiroaki Kitano.
  • Journal Title: Frontiers in Pharmacology Volume: 6 Pages: 186-186
  • DOI: 10.3389/fphar.2015.00186
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Accelerating systems biology research and its real world deployment. (2015)
  • Author(s): Kitano H.
  • Journal Title: npj Systems Biology and Applications Volume: 1 Issue: 1
  • DOI: 10.1038/npjsba.2015.9
  • Open Access
• [Journal Article] Elucidation of the molecular mechanisms underlying adverse reactions associated with a kinase inhibitor using systems toxicology. (2015)
  • Author(s): Takahiro Amemiya, Masashi Honma, Yoshiaki Kariya, Samik Ghosh, Hiroaki Kitano, Yoshihisa Kurachi, Ken-ichi Fujita, Yasutsuna Sasaki, Yukio Homma, Darrel R Abernethy, Haruki Kume, Hiroshi Suzuki.
  • Journal Title: npj Systems Biology and Applications Volume: 1 Issue: 1 Pages: 1-10
  • DOI: 10.1038/npjsba.2015.5
  • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
• [Journal Article] システム・トキシコロジーの展開（第2回）. (2015)
  • Author(s): 北野宏明.
  • Journal Title: QIAGEN eyes Volume: 13 Pages: 7-9
• [Journal Article] CARFMAP: A Curated Pathway Map of Cardiac Fibroblasts. (2015)
  • Author(s): Hieu T. Nim, Milena B. Furtado, Mauro W. Costa, Hiroaki Kitano, Nadia A. Rosenthal, Sarah E. Boyd.
  • Journal Title: PLoS ONE Volume: 10(12) Issue: 12 Pages: e0143274-e0143274
  • DOI: 10.1371/journal.pone.0143274
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] "TRP inflammation" relationship in cardiovascular system. (2015)
  • Author(s): Numata T, Takahashi K, Inoue R
  • Journal Title: Semin Immunopathol. Volume: 印刷中 Issue: 3 Pages: 339-356
  • DOI: 10.1007/s00281-015-0536-y
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Prediction of drug transfer into milk considering breast cancer resistance protein (BCRP)-mediated transport. (2015)
  • Author(s): Naoki Ito, Kousei Ito, Yuki Ikebuchi, Yu Toyoda, Tappei Takada, Akihiro Hisaka, Akira Oka, and Hiroshi Suzuki.
  • Journal Title: Pharm. Res. Volume: in press Pages: 2527-2537
  • DOI: 10.1007/s11095-015-1641-2
  • Peer Reviewed / Open Access
• [Journal Article] Modeling and prediction of solvent effect on human skin permeability using support vector regression and random forest. (2015)
  • Author(s): Hiromi Baba, Jun-ichi Takahara, Fumiyoshi Yamashita, Mitsuru Hashida.
  • Journal Title: Pharmaceutical Research Volume: 32(11) Issue: 11 Pages: 3604-3617
  • DOI: 10.1007/s11095-015-1720-4
  • Peer Reviewed
• [Journal Article] アセチルコリン感受性カリウム電流における短期脱感作のシミュレーション解析 (2015)
  • Author(s): 村上慎吾、稲野辺厚、倉智嘉久
  • Journal Title: 心電図 Volume: in press
  • NAID: 130005139477
  • Peer Reviewed
• [Journal Article] Clustering of Kir4.1 at specialized compartments of the lateral membrane in ependymal cells of rat brain (2015)
  • Author(s): Fujita A, Inanobe A, Hibino H, Nielsen S, Ottersen OP, Kurachi Y
  • Journal Title: Cell and Tissue Research Volume: 359(2) Issue: 2 Pages: 627-634
  • DOI: 10.1007/s00441-014-2030-6
  • Peer Reviewed
• [Journal Article] NKCCs in the fibrocytes of the spiral ligament are silent on the unidirectional K+ transport that controls the electrochemical properties in the mammalian cochlea (2015)
  • Author(s): Yoshida T, Nin F, Ogata G, Uetsuka S, Kitahara T, Inohara H, Akazawa K, Komune S, Kurachi Y, Hibino H
  • Journal Title: Pflugers Archiv - European Journal of Physiology Volume: in press Issue: 7 Pages: 1577-1589
  • DOI: 10.1007/s00424-014-1597-9
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] Oscillation of cAMP and Ca(2+) in cardiac myocytes: a systems biology approach (2015)
  • Author(s): Kamide T, Okumura S, Ghosh S, Shinoda Y, Mototani Y, Ohnuki Y, Jin H, Cai W, Suita K, Sato I, Umemura M, Fujita T, Yokoyama U, Sato M, Furutani K, Kitano H, Ishikawa Y
  • Journal Title: The Journal of Physiological Sciences Volume: 65(2) Issue: 2 Pages: 195-200
  • DOI: 10.1007/s12576-014-0354-3
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] システム制御学のもたらす変革~人間の認知限界を突破するために~ (2015)
  • Author(s): 北野宏明
  • Journal Title: 実験医学 Volume: 33 Pages: 100-108
  • Peer Reviewed
• [Journal Article] Intestinal myofibroblast TRPC6 channel may contribute to stenotic fibrosis in Crohn’s disease (2015)
  • Author(s): Lin Hai Kurahara, Miho Sumiyoshi, Kunihiko Aoyagi, Kyoko Nakajima, Midori Nakagawa, Keizo Hiraishi, Ryuji Inoue
  • Journal Title: Inflammatory Bowel Diseases Volume: 21(3) Issue: 3 Pages: 496-506
  • DOI: 10.1097/mib.0000000000000295
  • Peer Reviewed / Open Access
• [Journal Article] Dynamics of receptor-operated Ca2+ Currents Through TRPC Channels Controlled via the PI(4,5)P2-PLC Signaling Pathway (2015)
  • Author(s): Masayuki X Mori, Kyohei Itsuki, Hideharu Hase, Seishirou Sawamura, Tatsuki Kurokawa, Yasuo Mori, Ryuji Inoue
  • Journal Title: Frontiers in Pharmacology Volume: 6 Pages: 22-22
  • DOI: 10.3389/fphar.2015.00022
  • NAID: 120005663278
  • Peer Reviewed / Open Access
• [Journal Article] Analysis of the disposition of a novel p38 MAPK inhibitor, AKP-001, and its metabolites in rats with a simple physiologically based pharmacokinetic (2015)
  • Author(s): Shirota K, Kaneko M, Sasaki M, Minato K, Fujikata A, Ohta S, Hisaka A, Suzuki H
  • Journal Title: Drug Metabolism and Disposition Volume: 43 Issue: 2 Pages: 217-226
  • DOI: 10.1124/dmd.114.060046
  • Peer Reviewed
• [Journal Article] A new physiologically based pharmacokinetic model for the prediction of gastrointestinal drug absorption: translocation model (2015)
  • Author(s): Ando H, Hisaka A, Suzuki H
  • Journal Title: Drug Metabolism and Disposition Volume: 43 Issue: 4 Pages: 590-602
  • DOI: 10.1124/dmd.114.060038
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] Identification of NPC1L1 as a physiological vitamin K importer and a modulator of warfarin therapy. (2015)
  • Author(s): Tappei Takada, Yoshihide Yamanashi, Kentaro Konishi, Takehito Yamamoto, Yu Toyoda, Yusuke Masuo, Hideaki Yamamoto, and Hiroshi Suzuki.
  • Journal Title: Sci. Transl. Med. Volume: 7(275) Issue: 275
  • DOI: 10.1126/scitranslmed.3010329
  • Peer Reviewed / Open Access
• [Journal Article] Artificial neural network analysis for predicting human percutaneous absorption taking account of vehicle properties (2015)
  • Author(s): Tomomi Atobe, Masaaki Mori, Fumiyoshi Yamashita, Mitsuru Hashida, Hirokazu Kouzuki
  • Journal Title: The Journal of Toxicological Sciences Volume: 40 Issue: 2 Pages: 277-294
  • DOI: 10.2131/jts.40.277
  • NAID: 130004904033
  • ISSN: 0388-1350, 1880-3989
  • Peer Reviewed / Open Access
• [Journal Article] Multiple linear regression analysis indicates association of P-glycoprotein substrate or inhibitor character with bitterness intensity, measured with a sensor (2015)
  • Author(s): Kentaro Yano, Suzune Mita, Kaori Morimoto, Tamami Haraguchi, Hiroshi Arakawa, Miyako Yoshida, Fumiyoshi Yamashita, Takahiro Uchida, Takuo Ogihara
  • Journal Title: Journal of Pharmaceutical Sciences Volume: 104 Issue: 9 Pages: 2789-2794
  • DOI: 10.1002/jps.24232
  • Peer Reviewed / Open Access
• [Journal Article] A Versatile Platform for Multilevel Modeling of Physiological Systems: SBML-PHML Hybrid Modeling and Simulation (2014)
  • Author(s): Asai Y, Abe T, Oka H, Okita M, Hagihara K, Ghosh S, Matsuoka Y, Kurachi Y, Nomura T, Kitano H
  • Journal Title: Advanced Biomedical Engineering Volume: 3 Issue: 0 Pages: 50-58
  • DOI: 10.14326/abe.3.50
  • NAID: 130005001705
  • ISSN: 2187-5219
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Systems pharmacology for cardiac ion channels (2014)
  • Author(s): 古谷和春、倉智嘉久
  • Journal Title: Drug Delivery System Volume: 29 Issue: 5 Pages: 397-407
  • DOI: 10.2745/dds.29.397
  • NAID: 130004874239
  • ISSN: 0913-5006, 1881-2732
  • Peer Reviewed / Open Access
• [Journal Article] Ischemia-Related Subcellular Redistribution of Sodium Channels Enhances the Proarrhythmic Effect of Class I Antiarrhythmic Drugs: A Simulation Study (2014)
  • Author(s): Tsumoto K, Ashihara T, Haraguchi R, Nakazawa K, Kurachi Y
  • Journal Title: PLoS ONE Volume: 9(10) Issue: 10 Pages: e109271-e109271
  • DOI: 10.1371/journal.pone.0109271
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Physiome.jp におけるモデルデータベースとモデリング・シミュレーションプラットフォームとの連携 (2014)
  • Author(s): 浅井義之, 野村泰伸, 北野宏明
  • Journal Title: 計測と制御 Volume: 53(5) Pages: 426-431
  • NAID: 130005457952
  • Peer Reviewed
• [Journal Article] システムバイオロジーをオープニング・ゲームに使う~細胞老化研究の事例 (2014)
  • Author(s): 北野宏明
  • Journal Title: 実験医学 Volume: 32 Pages: 1288-1294
  • Peer Reviewed
• [Journal Article] 腫瘍内遺伝的多様性の数理 (2014)
  • Author(s): 北野宏明
  • Journal Title: SURGERY FRONTIER Volume: 21 Pages: 72-74
  • Peer Reviewed
• [Journal Article] 役立つモデルを作るのに必要なこと (2014)
  • Author(s): 北野宏明
  • Journal Title: 実験医学 Volume: 32 Pages: 1797-1802
  • Peer Reviewed
• [Journal Article] 生物学者のためのシステムサイエンス入門（第5回） (2014)
  • Author(s): 北野宏明
  • Journal Title: QIAGEN eyes Volume: 10 Pages: 7-9
  • Peer Reviewed
• [Journal Article] モデル構築におけるロバストネスとノイズ (2014)
  • Author(s): 北野宏明
  • Journal Title: 実験医学 Volume: 32 Pages: 2302-2311
  • Peer Reviewed
• [Journal Article] 情報プラットフォームと人工知能の登場 (2014)
  • Author(s): 北野宏明
  • Journal Title: 実験医学 Volume: 32 Pages: 2981-2988
  • Peer Reviewed
• [Journal Article] 生物学者のためのシステムサイエンス入門（第6回） (2014)
  • Author(s): 北野宏明
  • Journal Title: QIAGEN eyes Volume: 11 Pages: 7-9
  • Peer Reviewed
• [Journal Article] Software Platform for Systems Biology (2014)
  • Author(s): 浅井義之, 安部武志, 松岡由紀子, Samik Ghosh, 北野宏明
  • Journal Title: Drug Delivery System Volume: 29 Issue: 5 Pages: 386-396
  • DOI: 10.2745/dds.29.386
  • NAID: 130004874238
  • ISSN: 0913-5006, 1881-2732
  • Peer Reviewed / Open Access
• [Journal Article] TRPチャネルを介した心不整脈発生機序 (2014)
  • Author(s): 井上隆司、胡耀鵬
  • Journal Title: 実験医学 Volume: 32(4) Pages: 534-539
  • Peer Reviewed
• [Journal Article] ポドサイトを標的とした基礎研究の新展開 －Podocytology がひらく新しい慢性腎臓病治療戦略 (2014)
  • Author(s): 井上隆司、淺沼克彦、関 卓人、長瀬美樹、長船健二
  • Journal Title: 日本薬理学会誌 Volume: 143(3) Pages: 27-33
  • NAID: 130004827686
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] 眼科領域におけるTRPチャネルの生理・病態生理的役割 (2014)
  • Author(s): 井上隆司
  • Journal Title: 眼薬理 Volume: 28 Pages: 11-27
  • Peer Reviewed
• [Journal Article] PLC-mediated PI(4,5)P2 hydrolysis regulates activation and inactivation of TRPC6/7 channels (2014)
  • Author(s): Kyohei Itsuki, Yuko Imai, Hideharu Hase, Yasushi Okamura, Ryuji Inoue, and Masayuki Mori
  • Journal Title: Journal of General Physiology Volume: 143(2) Issue: 2 Pages: 183-201
  • DOI: 10.1085/jgp.201311033
  • Peer Reviewed / Open Access
• [Journal Article] TRPC6 regulates cell cycle progression by modulating membrane potential in bone marrow stromal cells (2014)
  • Author(s): Jun Ichikawa, Ryuji Inoue
  • Journal Title: British Journal of Pharmacology Volume: 171(23) Issue: 23 Pages: 5280-5294
  • DOI: 10.1111/bph.12840
  • Peer Reviewed
• [Journal Article] BDNF induces sustained intracellular Ca2+ elevation through the upregulation of surface TRPC3 channels in rodent microglia (2014)
  • Author(s): Mizoguchi Y, Kato TA, Seki Y, Ohgidani M, Sagata N, Horikawa H, Yamauchi Y, Sato-Kasai M, Hayakawa K, Inoue R, Kanba S, Monji A
  • Journal Title: Journal of Biological Chemistry Volume: 289(26) Issue: 26 Pages: 18549-18555
  • DOI: 10.1074/jbc.m114.555334
  • Peer Reviewed
• [Journal Article] New Experimental Trends for Phosphoinositides Research on Ion Transporter/Channel Regulation (2014)
  • Author(s): Masayuki X. Mori, Ryuji Inoue
  • Journal Title: Journal of Pharmacological Sciences Volume: 126 Issue: 3 Pages: 186-197
  • DOI: 10.1254/jphs.14R14CP
  • NAID: 130004704282
  • ISSN: 1347-8613, 1347-8648
  • Peer Reviewed / Open Access
• [Journal Article] Assessment of Intestinal Availability (FG) of Substrate Drugs of Cytochrome P450s by Analyzing Changes in Pharmacokinetic (2014)
  • Author(s): Hisaka A, Nakamura M, Tsukihashi A, Koh S, Suzuki H
  • Journal Title: Drug Metabolism and Disposition Volume: 42 Issue: 10 Pages: 1640-1645
  • DOI: 10.1124/dmd.114.059147
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] Organic cation transporter/solute carrier family 22a is involved in drug transfer into milk in mice. (2014)
  • Author(s): Naoki Ito, Kousei Ito, Yuki Ikebuchi, Tomoko Kito, Hiroshi Miyata, Yu Toyoda, Tappei Takada, Akihiro Hisaka, Masashi Honma, Akira Oka, Hiroyuki Kusuhara, and Hiroshi Suzuki.
  • Journal Title: J. Pharm. Sci. Volume: 103(10) Issue: 10 Pages: 3342-8
  • DOI: 10.1002/jps.24138
  • Peer Reviewed / Open Access
• [Journal Article] Suppression of experimental arthritis with self-assembling glycol-split heparin nanoparticles via inhibition of TLR4-NF-κB signaling (2014)
  • Author(s): Hasan Babazada, Fumiyoshi Yamashita, Mitsuru Hashida
  • Journal Title: Journal of Controlled Release Volume: 194 Pages: 295-300
  • DOI: 10.1016/j.jconrel.2014.09.015
  • NAID: 120005512274
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] Self-assembling lipid modified glycol-split heparin nanoparticles suppress lipopolysaccharide-induced inflammation through TLR4-NF-κB signaling (2014)
  • Author(s): Hasan Babazada, Fumiyoshi Yamashita, Shinya Yanamoto, Mitsuru Hashida
  • Journal Title: Journal of Controlled Release Volume: 194 Pages: 332-340
  • DOI: 10.1016/j.jconrel.2014.09.011
  • NAID: 120005512273
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] Membrane channels as integrators of G-protein-mediated signaling (2014)
  • Author(s): Atsushi Inanobe, Yoshihisa Kurachi
  • Journal Title: Biochimica et Biophysica Acta Volume: 1838 (2) Issue: 2 Pages: 521-531
  • DOI: 10.1016/j.bbamem.2013.08.018
  • Peer Reviewed
• [Journal Article] RGS4 regulates partial agonism of the M2 muscarinic receptor-activated K+ currents (2014)
  • Author(s): I‐Shan Chen, Kazuharu Furutani, Atsushi Inanobe and Yoshihisa Kurachi
  • Journal Title: Journal of Physiology (London) Volume: 592(6) Issue: 6 Pages: 1237-1248
  • DOI: 10.1113/jphysiol.2013.269803
  • Peer Reviewed
• [Journal Article] Regulatory mechanisms of RANKL presentation to osteoclast precursors (2014)
  • Author(s): Masashi Honma, Yuki Ikebuchi, Yoshiaki Kariya, Hiroshi Suzuki
  • Journal Title: Current Osteoporosis Reports Volume: 12(1) Issue: 1 Pages: 115-120
  • DOI: 10.1007/s11914-014-0189-0
  • Peer Reviewed
• [Journal Article] Establishment of optimized in vitro assay methods for evaluating osteocyte functions (2014)
  • Author(s): Masashi Honma, Yuki Ikebuchi, Yoshiaki Kariya, Hiroshi Suzuki
  • Journal Title: Journal of Bone and Mineral Metabolism Volume: in press Issue: 1 Pages: 1-12
  • DOI: 10.1007/s00774-013-0555-5
  • Peer Reviewed
• [Journal Article] Bilinear Model for the Size-Dependency of the CYP3A4 Inhibitory Activity of Structurally Diverse Compounds (2014)
  • Author(s): Peter Buchwald, Fumiyoshi Yamashita
  • Journal Title: Molecular Informatics Volume: 33 Issue: 1 Pages: 8-14
  • DOI: 10.1002/minf.201300132
  • Peer Reviewed
• [Journal Article] Basolateral Mg2+ extrusion via CNNM4 mediates transcellular Mg2+ transport across epithelia: a mouse model (2013)
  • Author(s): Daisuke Yamazaki, Yosuke Funato, Jiro Miura, Sunao Sato, Satoru Toyosawa, Kazuharu Furutani, Yoshihisa Kurachi, Yoshihiro Omori, Takahisa Furukawa, Tetsuya Tsuda, Susumu Kuwabata, Shin Mizukami, Kazuya Kikuchi, Hiroaki Miki
  • Journal Title: PLoS Genetics Volume: 9(12) Issue: 12 Pages: e1003983-e1003983
  • DOI: 10.1371/journal.pgen.1003983
  • Peer Reviewed
• [Journal Article] Conformational changes underlying pore dilation in the cytoplasmic domain of mammalian inward rectifier K+ channels (2013)
  • Author(s): Atsushi Inanobe, Atsushi Nakagawa, Yoshihisa Kurachi
  • Journal Title: PLoS One Volume: 8 (11) Issue: 11 Pages: e79844-e79844
  • DOI: 10.1371/journal.pone.0079844
  • NAID: 120006770871
  • Peer Reviewed / Open Access
• [Journal Article] Short-term desensitization of muscarinic K+ current in the heart (2013)
  • Author(s): Shingo Murakami, Atsushi Inanobe, Yoshihisa Kurachi
  • Journal Title: Biophysical Journal Volume: 105(6) Issue: 6 Pages: 1515-1525
  • DOI: 10.1016/j.bpj.2013.08.009
  • Peer Reviewed
• [Journal Article] The mechanism underlying maintenance of the endocochlear potential by the K+ transport system in fibrocytes of the inner ear (2013)
  • Author(s): Naoko Adachi, Takamasa Yoshida, Fumiaki Nin, Genki Ogata, Soichiro Yamaguchi, Toshihiro Suzuki, Sizuo Komune, Yasuo Hisa, Hiroshi Hibino and Yoshihisa Kurachi
  • Journal Title: Journal of Physiology (London) Volume: 591(18) Issue: 18 Pages: 4459-4472
  • DOI: 10.1113/jphysiol.2013.258046
  • Peer Reviewed
• [Journal Article] Expressional analysis of inwardly rectifying Kir4.1 channels in Noda epileptic rat (NER) (2013)
  • Author(s): Yuya Harada, Yuki Nagao, Saki Shimizu, Tadao Serikawa, Ryo Terada, Megumi Fujimoto, Aoi Okuda, Takahiro Mukai, Masashi Sasa, Yoshihisa Kurachi, Yukihiro Ohno
  • Journal Title: Brain Research Volume: 1517 Pages: 141-149
  • DOI: 10.1016/j.brainres.2013.04.009
  • Peer Reviewed
• [Journal Article] Toward an integrated software platform for systems pharmacology (2013)
  • Author(s): Samik Ghosh, Yukiko Matsuoka, Yoshiyuki Asai, Kun-Yi Hsin, Hiroaki Kitano
  • Journal Title: Biopharmaceutics & Drug Disposition Volume: 34(9) Issue: 9 Pages: 508-526
  • DOI: 10.1002/bdd.1875
  • Peer Reviewed / Open Access
• [Journal Article] Combining machine learning systems and multiple docking simulation packages to improve docking prediction reliability for network pharmacology (2013)
  • Author(s): Kun-Yi Hsin, Samik Ghosh and Hiroaki Kitano
  • Journal Title: PLOS ONE Volume: 8(12) Issue: 12 Pages: e83922-e83922
  • DOI: 10.1371/journal.pone.0083922
  • Peer Reviewed
• [Journal Article] Harnessing Diversity towards the Reconstructing of Large Scale Gene Regulatory Networks (2013)
  • Author(s): Takeshi Hase, Samik Ghosh, Ryota Yamanaka, Hiroaki Kitano
  • Journal Title: PLOS Computational Biology Volume: 9(11) Issue: 11 Pages: e1003361-e1003361
  • DOI: 10.1371/journal.pcbi.1003361
  • Peer Reviewed
• [Journal Article] Molecular determinants for cardiovascular TRPC6 channel regulation by Ca2+/calmodulin-dependent kinase II (2013)
  • Author(s): Juan Shi, Naomi Geshi, Shinichi Takahashi, Shigeki Kiyonaka, Jun Ichikawa, Yaopeng Hu, Yasuo Mori, Yushi Ito, Ryuji Inoue
  • Journal Title: Journal of Physiology (London) Volume: 591(11) Issue: 11 Pages: 2851-2866
  • DOI: 10.1113/jphysiol.2013.251249
  • Peer Reviewed
• [Journal Article] Novel HCN2 mutation contributes to febrile seizures by shifting the channel's kinetics in a temperature-dependent manner (2013)
  • Author(s): Yuki Nakamura, Xiuyu Shi, Tomohiro Numata, Yasuo Mori, Ryuji Inoue, Christoph Lossin, Tallie Z. Baram, Shinichi Hirose
  • Journal Title: PLoS One Volume: 8(12) Issue: 12 Pages: e80376-e80376
  • DOI: 10.1371/journal.pone.0080376
  • Peer Reviewed
• [Journal Article] Systems-based understanding of pharmacological responses with combinations of multidisciplinary methodologies (2013)
  • Author(s): Yoshiaki Kariya, Masashi Honma, Hiroshi Suzuki
  • Journal Title: Biopharmaceutics & Drug Disposition Volume: 28(9) Issue: 9 Pages: 1936-1949
  • DOI: 10.1002/jbmr.1941
  • Peer Reviewed
• [Journal Article] Modeling of rifampicin-induced CYP3A4 activation dynamics for the prediction of clinical drug-drug interactions from in vitro data (2013)
  • Author(s): Fumiyoshi Yamashita, Yukako Sasa, Shuya Yoshida, Akihiro Hisaka, Yoshiyuki Asai, Hiroaki Kitano, Mitsuru Hashida, Hiroshi Suzuki
  • Journal Title: PLoS One Volume: 8(9) Issue: 9 Pages: 1-11
  • DOI: 10.1371/journal.pone.0070330
  • NAID: 120005343920
  • Peer Reviewed / Open Access
• [Journal Article] Contribution of Protein Binding, Lipid Partitioning, and Asymmetrical Transport to Drug Transfer into Milk in Mouse Versus Human (2013)
  • Author(s): Naoki Ito, Kousei Ito, Hiroki Koshimichi, Akihiro Hisaka, Masashi Honma, Takashi Igarashi, Hiroshi Suzuki
  • Journal Title: Pharmaceutical Research Volume: 30(9) Issue: 9 Pages: 2410-2422
  • DOI: 10.1007/s11095-013-1085-5
  • Peer Reviewed
• [Journal Article] Automated extraction of information on chemical-P-glycoprotein interactions from the literature (2013)
  • Author(s): Shuya Yoshida, Fumiyoshi Yamashita, Atsushi Ose, Kazuya Maeda, Yuichi Sugiyama, Mitsuru Hashida
  • Journal Title: Journal of Chemical Information and Modeling Volume: 53 Issue: 10 Pages: 2506-2510
  • DOI: 10.1021/ci4003188
  • Peer Reviewed
• [Journal Article] Adding Protein Context to the Human Protein-Protein Interaction Network to Reveal Meaningful Interactions (2013)
  • Author(s): Martin H. Schaefer, Tiago J. S. Lopes, Nancy Mah, Jason E. Shoemaker, Yukiko Matsuoka, Jean-Fred Fontaine, Caroline Louis-Jeune, Amie J. Eisfeld, Gabriele Neumann, Carol Perez-Iratxeta, Yoshihiro Kawaoka, Hiroaki Kitano, Miguel A. Andrade-Navarro
  • Journal Title: PLOS Computational Biology Volume: 9 Issue: 1 Pages: 1-1
  • DOI: 10.1371/journal.pcbi.1002860
  • Peer Reviewed
• [Journal Article] Identification of dosage-sensitive genes in Saccharomyces cerevisiae using the genetic tug-of-war method (2013)
  • Author(s): Koji Makanae, Reiko Kintaka, Takashi Makino, Hiroaki Kitano and Hisao Moriya
  • Journal Title: Genome Research Volume: 23 Issue: 2 Pages: 300-311
  • DOI: 10.1101/gr.146662.112
  • Peer Reviewed
• [Journal Article] Ticlopidine, a Cholestatic Liver Injury-Inducible Drug, Causes Dysfunction of Bile Formation via Diminished Biliary Secretion of Phospholipids: Involvement of Biliary-Excreted Glutathione-Conjugated Ticlopidine Metabolites (2013)
  • Author(s): Takashi Yoshikado, Tappei Takada, Hideaki Yamamoto, Jeng Kae Tan, Kousei Ito, Tomofumi Santa, Hiroshi Suzuki
  • Journal Title: Molecular Pharmacology Volume: 83(2) Issue: 2 Pages: 552-562
  • DOI: 10.1124/mol.112.081752
  • Peer Reviewed
• [Journal Article] A computational model of a circulation current that controls electrochemical properties in the mammalian cochlea (2012)
  • Author(s): Fumiaki Nin, Hiroshi Hibino, Shingo Murakami, Toshihiro Suzuki, Yasuo Hisa, Yoshihisa Kurachi
  • Journal Title: Proceedings of the National Academy of Sciences of USA Volume: 109 Issue: 23 Pages: 9191-9196
  • DOI: 10.1073/pnas.1120067109
  • Peer Reviewed
• [Journal Article] A framework for mapping, visualisation and automatic model creation of signal-transduction networks (2012)
  • Author(s): Carl-Fredrik Tiger, Falko Krause, Gunnar Cedersund, Robert Palmer, Edda Klipp, Stefan Hohmann, Hiroaki Kitano and Marcus Krantz
  • Journal Title: Molecular Systems Biology Volume: 8 Issue: 1 Pages: 578-578
  • DOI: 10.1038/msb.2012.12
  • Peer Reviewed
• [Journal Article] Software support for SBGN maps: SBGN-ML and LibSBGN (2012)
  • Author(s): Martijn P. van Iersel, Alice C. Villéger, Tobias Czauderna, Sarah E. Boyd, Frank T. Bergmann, Augustin Luna, Emek Demir, Anatoly Sorokin, Ugur Dogrusoz, Yukiko Matsuoka, Akira Funahashi, Mirit I. Aladjem, Huaiyu Mi, Stuart L. Moodie, Hiroaki Kitano, Nicolas Le Novère, and Falk Schreiber
  • Journal Title: Bioinformatics Volume: 28(15) Issue: 15 Pages: 2016-2021
  • DOI: 10.1093/bioinformatics/bts270
  • Peer Reviewed
• [Journal Article] CTen: a web-based platform for identifying enriched cell types from heterogeneous microarray data (2012)
  • Author(s): Jason E Shoemaker, Tiago JS Lopes, Samik Ghosh, Yukiko Matsuoka, Yoshihiro Kawaoka and Hiroaki Kitano
  • Journal Title: BMC Genomics Volume: 13(1) Issue: 1 Pages: 460-460
  • DOI: 10.1186/1471-2164-13-460
  • Peer Reviewed
• [Journal Article] Integrated network analysis reveals a novel role for the cell cycle in 2009 pandemic influenza virus-induced inflammation in macaque lungs (2012)
  • Author(s): Jason E Shoemaker, Satoshi Fukuyama, Amie J Eisfeld, Yukiko Muramoto, Shinji Watanabe, Tokiko Watanabe, Yukiko Matsuoka, Hiroaki Kitano and Yoshihiro Kawaoka
  • Journal Title: BMC Systems Biology Volume: 6 Issue: 1 Pages: 117-117
  • DOI: 10.1186/1752-0509-6-117
  • Peer Reviewed
• [Journal Article] Critical role of TRPC1-mediated Ca2+ entry in decidualization of human endometrial stromal cells (2012)
  • Author(s): Yasuhiro Kawarabayashi, Lin Hai, Akira Honda, Shinji Horiuchi, Hiroshi Tsujioka, Jun Ichikawa, Ryuji Inoue
  • Journal Title: Molecular Endocrinology Volume: 26(5) Issue: 5 Pages: 846-858
  • DOI: 10.1210/me.2011-1259
  • Peer Reviewed
• [Journal Article] Decreased extra-renal urate excretion is a common cause of hyperuricemia (2012)
  • Author(s): Kimiyoshi Ichida, Hirotaka Matsuo, Tappei Takada, et al (Hiroshi Suzuki)
  • Journal Title: Nature Communication Volume: 3 Issue: 1 Pages: 1-7
  • DOI: 10.1038/ncomms1756
  • Peer Reviewed
• [Journal Article] Pharmacophore modeling for hERG channel facilitation (2012)
  • Author(s): Yamakawa, Y., Furutani, K., Inanobe, A., Ohno, Y., Kurachi, Y.
  • Journal Title: Biochemical and Biophysical Research Communications Volume: 418(1) Issue: 1 Pages: 161-166
  • DOI: 10.1016/j.bbrc.2011.12.153
  • Peer Reviewed
• [Journal Article] Critical Role of TRPC1-mediated Ca^<2+> entry in Decidualization of Human Endometrial Stromal Cells (2012)
  • Author(s): Yasuhiro Kawarabayashi, Lin Hai, Akira Honda, Shinji Horiuchi, Hiroshi Tsujioka, Ryuji Inoue
  • Journal Title: Molecular Endocrinology Volume: (in press)
  • Peer Reviewed
• [Journal Article] Novel function of Niemann-Pick C1-like 1 as a negative regulator of Niemann-Pick C2 protein (2012)
  • Author(s): Yoshihide Yamanashi, Tappei Takada, Jun-Ichi Shoda, Hiroshi Suzuki
  • Journal Title: Hepatology Volume: 55(3) Issue: 3 Pages: 953-964
  • DOI: 10.1002/hep.24772
  • Peer Reviewed
• [Journal Article] A self-limiting regulation of TRPC3/C6/C7 channels coupled with PI(4,5)P2-diacylglycerol signalling. (2011)
  • Author(s): Imai Y, Itsuki K, Okamura Y, Inoue R, Mori MX
  • Journal Title: The Journal of Physiology Volume: 590 Issue: 5 Pages: 1101-1119
  • DOI: 10.1113/jphysiol.2011.221358
  • Peer Reviewed
• [Journal Article] Interactions of cations with the cytoplasmic pores of inward rectifier K+channels in the closed state (2011)
  • Author(s): Atsushi Inanobe, Atsushi Nakagawa, Yoshihisa Kurachi
  • Journal Title: Journal of Biological Chemistry Volume: 286(48) Issue: 48 Pages: 41801-41811
  • DOI: 10.1074/jbc.m111.278531
  • NAID: 120006770868
  • Peer Reviewed
• [Journal Article] Inverse agonist-like action of cadmium on G-protein-gated inward-rectifier K+channels (2011)
  • Author(s): Atsushi Inanobe, Takanori Matsuura, Atsushi Nakagawa, Yoshihisa Kurachi
  • Journal Title: Biochemical and Biophysical Research Communications Volume: 407(2) Issue: 2 Pages: 366-371
  • DOI: 10.1016/j.bbrc.2011.03.025
  • Peer Reviewed
• [Journal Article] Randomized trial of angiotensin II-receptor blocker vs.dihydropiridine calcium channel blocker in the treatment of paroxysmal atrial fibrillation with hypertension (J-RHYTHM II study) (2011)
  • Author(s): Takeshi Yamashita, Hiroshi Inoue, Ken Okumura, Itsuo Kodama, Yoshifusa Aizawa, Hirotsugu Atarashi, Tohru Ohe, Hiroshi Ohtsu, Takao Kato, Shiro Kamakura, Koichiro Kumagai, Yoshihisa Kurachi, Yukihiro Koretsune, Tetsunori Saikawa, Masayuki Sakurai, Toshiaki Sato, Kaoru Sugi, Haruaki Nakaya, Makoto Hirai, Atsushi Hirayama, Masahiko Fukatani, Hideo Mitamura, Tsutomu Yamazaki, Eiichi Watanabe, Satoshi Ogawa, on behalf of the J-RHYTHM II Investigators
  • Journal Title: Europace Volume: 13(4) Issue: 4 Pages: 473-479
  • DOI: 10.1093/europace/euq439
  • Peer Reviewed
• [Journal Article] A mechanism underlying compound-induced voltage shift in the current activation of hERG by antiarrhythmic agents (2011)
  • Author(s): Furutani, K., Yamakawa, Y., Inanobe, A., Iwata, M., Ohno, Y., Kurachi, Y.
  • Journal Title: A mechanism underlying compound-induced voltage shift in the current activation of hERG by antiarrhythmic agents Volume: 415(1) Issue: 1 Pages: 141-146
  • DOI: 10.1016/j.bbrc.2011.10.034
  • Peer Reviewed
• [Journal Article] Social engineering for virtual 'big science' in systems biology (2011)
  • Author(s): Hiroaki Kitano, Samik Ghosh, Yukiko Matsuoka
  • Journal Title: Nature Chemical Biology Volume: 7 Issue: 6 Pages: 323-326
  • DOI: 10.1038/nchembio.574
  • Peer Reviewed
• [Journal Article] Software for systems biology : from tools to integrated platforms (2011)
  • Author(s): Samik Ghosh, Yukiko Matsuoka, Yoshiyuki Asai, Kun-Yi Hsin, Hiroaki Kitano
  • Journal Title: Nature Reviews Genetics Volume: 12 Issue: 12 Pages: 821-832
  • DOI: 10.1038/nrg3096
  • Peer Reviewed
• [Journal Article] Dual Signaling Pathways of Arterial Constriction by Extracellular Uridine 5'-Triphosphate in the Rat (2011)
  • Author(s): Sugihara M, Morita H, Matsuda M, Umebayashi H, Kajioka S, Ito S, Nishida M, Inoue R, Futatsuki T, Yamazaki J, Mori Y, Inoue R, Ito Y, Abe K, Hirata M
  • Journal Title: Journal of Pharmacological Sciences Volume: 115 Issue: 3 Pages: 293-308
  • DOI: 10.1254/jphs.10281FP
  • NAID: 10029892471
  • ISSN: 1347-8613, 1347-8648
  • Peer Reviewed
• [Journal Article] Protein kinase A-mediated phosphorylation of TRPC6 channels underlies suppression of angiotensin II-induced vasoconstriction (2011)
  • Author(s): Nishioka K, Nishida M, Ariyoshi M, Saiki S, Jian Z, Hirano M, Nakaya M, Sato Y, Kita S, Iwamoto T, Hirano K, Inoue R, Kurose H
  • Journal Title: Arterioscler.Thromb.Vasc.Biol. Volume: 31 Issue: 10 Pages: 2278-2286
  • DOI: 10.1161/atvbaha.110.221010
  • Peer Reviewed
• [Journal Article] Quantitative measurement of intracellular Ca^<2+> and calmodulin binding to target molecules using Fura-2 and CFP/YFP based FRET imaging in living cells (2011)
  • Author(s): Mori MX, Imai Y, Itsuki K, Inoue R.
  • Journal Title: Biochemistry Volume: 50(21) Issue: 21 Pages: 4685-96
  • DOI: 10.1021/bi200287x
  • Peer Reviewed
• [Journal Article] Counteracting effect of TRPC1-associated Ca^<2+> influx on TNFα-induced COX-2-dependent prostaglandin E_2 production in human colonic myofibroblasts (2011)
  • Author(s): Hai L, Kawarabayashi Y, Imai Y, Honda A, Inoue R.
  • Journal Title: American Journal of Physiology-Gastrointestinal and Liver Physiology Volume: 301(2) Issue: 2 Pages: G356-G367
  • DOI: 10.1152/ajpgi.00354.2010
  • Peer Reviewed
• [Journal Article] BKCa and KV channels limit conducted vasomotor responses in rat mesenteric terminal arterioles (2011)
  • Author(s): Hald BO, Jacobsen JCB, Braunstein TH, Inoue R, Ito Y, Sorensen PG, Holstein-Rathlou NH, Jensen LJ.
  • Journal Title: Pflugers Archiv Eur J Physiol Volume: 463(2) Issue: 2 Pages: 279-95
  • DOI: 10.1007/s00424-011-1049-8
  • Peer Reviewed
• [Journal Article] NPC2 regulates biliary cholesterol secretion via stimulation of ABCG5/G8-mediated cholesterol transport (2011)
  • Author(s): Yoshihide Yamanashi, Tappei Takada, Takashi Yoshikado, Jun-Ichi Shoda, Hiroshi Suzuki
  • Journal Title: Gastroenterology Volume: 140(5) Issue: 5 Pages: 1664-1674
  • DOI: 10.1053/j.gastro.2011.01.050
  • Peer Reviewed
• [Journal Article] Off-target serine/threonine kinase 10 inhibition by erlotinib enhances lymphocytic activity leading to severe skin disorders (2011)
  • Author(s): Naoko Yamamoto, Masashi Honma, Hiroshi Suzuki
  • Journal Title: Molecular Pharmacology Volume: 80 Issue: 3 Pages: 466-475
  • DOI: 10.1124/mol.110.070862
  • Peer Reviewed
• [Journal Article] Proposal of a pharmacokinetically optimized dosage regimen of antibiotics in patients receiving continuous hemodiafiltration (2011)
  • Author(s): Takehito Yamamoto, Nobuhiro Yasuno, Shoichi Katada, Akihiro Hisaka, Norio Hanafusa, Eisei Noiri, Naoki Yahagi, Toshiro Fujita, Hiroshi Suzuki
  • Journal Title: Antimicrobial Agents and Chemotherapy Volume: 55(12) Issue: 12 Pages: 5804-5812
  • DOI: 10.1128/aac.01758-10
  • Peer Reviewed
• [Journal Article] Analysis and prediction of drug transfer into human milk taking into consideration secretion and reuptake clearances across the mammary epithelia (2011)
  • Author(s): Hiroki Koshimichi, Kousei Ito, Akihiro Hisaka, Masashi Honma, Hiroshi Suzuki
  • Journal Title: Drug Metabolism and Disposition Volume: 39(12) Issue: 12 Pages: 2370-2380
  • DOI: 10.1124/dmd.111.040972
  • Peer Reviewed
• [Journal Article] Roles of Subcellular Na^+ Channel Distributions in the Mechanism of Cardiac Conduction (2011)
  • Author(s): Kunichika Tsumoto, Takashi Ashihara, Ryo Haraguchi, Kazuo Nakazawa, Yoshihisa Kurachi
  • Journal Title: Biophysical Journal Volume: 100(3) Pages: 554-563
  • Peer Reviewed
• [Journal Article] Transmural dispersion of repolarization determines scroll wave behavior during ventricular tachyarrhythmias (2011)
  • Author(s): Ryo Haraguchi, Takashi Ashihara, Tsunetoyo Namba, Kunichika Tsumoto, Murakami Shingo, Yoshihisa Kurachi, Takanori Ikeda, Kazuo Nakazawa
  • Journal Title: Circulation Journal Volume: 75(1) Pages: 80-88
  • Peer Reviewed
• [Journal Article] Regulation of cardiovascular TRP channel functions along the NO-cGMP-PKG axis (2011)
  • Author(s): Ryuii Inoue, Juan Shi, Zhong Jian, Yuko Imai
  • Journal Title: Expert Review of Clinical Pharmacology Volume: 3(3) Pages: 347-360
  • Peer Reviewed
• [Journal Article] NPC2 regulates biliary cholesterol secretion via stimulation of ABCGS/G8-mediated cholesterol transport (2011)
  • Author(s): Yoshihide Yamanashi, Tappei Takada, Takashi Yoshikado, Jun-ichi Shoda, Hiroshi Suzuki
  • Journal Title: Gastroenterology Volume: (In press)
  • Peer Reviewed
• [Journal Article] Serum Metabolomics Reveals γ-Glutamyl Dipeptides as Biomarkers for Discrimination among Different Forms of Liver Disease (2011)
  • Author(s): Tomoyoshi Soga, Masahiro Sugimoto, Masashi Honma, Masayo Mori, Kaori Igarashi, Kasumi Kashikura, Satsuki Ikeda, Akiyoshi Hirayama, Takehito Yamamoto, Haruhiko Yoshida, Motoyuki Otsuka, Shoji Tsuji, Yutaka Yatomi, Tadayuki Sakuragawa, Hisayoshi Watanabe, Kouei Nihei, Takafumi Saito, Sumio Kawata, Hiroshi Suzuki, Masaru Tomita, Makoto Suematsu
  • Journal Title: Journal of Hepatology Volume: (In press)
  • Peer Reviewed
• [Journal Article] Rab27a and Rab27b are involved in stimulation-dependent RANKL release from secretory lysosomes in osteoblastic cells (2011)
  • Author(s): Yoshiaki Kariya, Masashi Honma, Akiko Hanamura, Shigeki Aoki, Tadashi Ninomiya, Yuko Nakamichi, Nobuyuki Udagawa, Hiroshi Suzuki
  • Journal Title: Journal of Bone and Mineral Research Volume: (In press)
  • Peer Reviewed
• [Journal Article] Simultaneous absolute quantification of 11 cytochrome P450 isoforms in human liver microsomes by liquid chromatography tandem mass spectrometry with in silico target peptide selection (2011)
  • Author(s): Hirotaka Kawakami, Sumio Ohtsuki, Junichi Kamiie, Takashi Suzuki, Takaaki Abe, Tetsuya Terasaki
  • Journal Title: Journal of Pharmaceutical Sciences Volume: 100 Pages: 341-352
  • Peer Reviewed
• [Journal Article] A structural determinant for the control of PIP_2 sensitivity in G protein-gated inward rectifier K^+ channels (2010)
  • Author(s): Atsushi Inanobe, Atsushi Nakagawa, Takanori Matsuura, Yoshihisa Kurachi
  • Journal Title: Journal of Biological Chemistry Volume: 285(49) Pages: 38517-38523
  • NAID: 120006770864
  • Peer Reviewed
• [Journal Article] Large-scale analysis of network bistability for human cancers (2010)
  • Author(s): Tetsuya Shiraishi, Shinako Matsuyama, Hiroaki Kitano
  • Journal Title: PLoS Computational Biology Volume: 16(7)
  • Peer Reviewed
• [Journal Article] A comprehensive molecular interaction map of the budding yeast cell cycle. (2010)
  • Author(s): Kazunari Kaizu, Samik Ghosh, Yukiko Matsuoka, Hisao Moriya, Yuki Shimizu-Yoshida, Hiroaki Kitano
  • Journal Title: Molecular Systems Biology Volume: 6 Pages: 415-415
  • Peer Reviewed
• [Journal Article] A comprehensive map of the mTOR signaling network (2010)
  • Author(s): Etienne Caron, Samik Ghosh, Yukiko Matsuoka, Dariel Ashton-Beaucagel, Marc Therrien, Sebastien Lemieux, Claude Perreault, Philippe P Roux, Hiroaki Kitano
  • Journal Title: Molecular Systems Biology Volume: 6 Pages: 453-453
  • Peer Reviewed
• [Journal Article] システムバイオロジーにおける情報基盤 (2010)
  • Author(s): 北野宏明、松岡由希子、Samik Ghosh
  • Journal Title: 計測と制御 Volume: 49(8) Pages: 507-512
  • NAID: 10026585732
  • Peer Reviewed
• [Journal Article] 細胞シミュレータCellDesignerの設計と実装 (2010)
  • Author(s): 舟橋啓、松岡由希子、上樂明也、瀧沢大夢、広井賀子、Samik Ghosh、菊池紀広、北野宏明
  • Journal Title: 計測と制御 Volume: 49(8) Pages: 531-536
  • NAID: 10026585798
  • Peer Reviewed
• [Journal Article] Connecting the dots : role of standardization and technology sharing in biological simulation (2010)
  • Author(s): Samik Ghosh, Yukiko Matsuoka, Hiroaki Kitano
  • Journal Title: Drug Discovery Today Volume: 15 Pages: 1024-1031
  • Peer Reviewed
• [Journal Article] Inhibition of TRPC6 Channel Activity contributes to the Anti-hypertrophic Effects of Natriuretic Peptides-guanylyl cyclase-A signaling in the heart (2010)
  • Author(s): Hideyuki Kinoshita, Koichiro Kuwahara, Motohiro Nishida, Jian Zhong, Xianglu Rong, Shigeki Kiyonaka, Yoshihiro Kuwabara, Hitoshi Kurose, Ryuji Inoue, Yasuo Mori, Yuhao Li, Yasuaki Nakagawa, Masao Murakami, Masaki Harada, Shinji Yasuno, Satoru Usami, Masataka Fujiwara, Yuko Yamada, Takeya Minami, Kenji Ueshima, Eric N.Olson, Kazuwa Nakao
  • Journal Title: Circulation Research Volume: 106(12) Pages: 1849-1860
  • Peer Reviewed
• [Journal Article] Phosphorylation of TRPC6 channels at Thr^<69> is required for anti-hypertrophic effects of phosphodiesterase 5 inhibition (2010)
  • Author(s): Motohiro Nishida, Kenta Watanabe, Yoji Sato, Michio Nakaya, Naoyuki Kitajima, Tomomi Ide, Ryuji Inoue, Hitoshi Kurose
  • Journal Title: Journal of Biological Chemistry Volume: 285(17) Pages: 13244-13253
  • Peer Reviewed
• [Journal Article] Ca^<2+> Influx and protein scaffolding via TRPC3 sustain PKCβ and ERK activation in B cells (2010)
  • Author(s): Takuro Numaga, Motohiro Nishida, Shigeki Kiyonaka, Kenta Kato, Masahiro Katano, Emiko Mori, Tomohiro Kurosaki, Ryuii Inoue, Masaki Hikida, James W Putney, Jr, Yasuo Mori
  • Journal Title: Journal of Cell Science Volume: 123(6) Pages: 927-938
  • Peer Reviewed
• [Journal Article] Itraconazole-induced cholestasis : involvement of the inhibition of bile canalicular phospholipid translocator MDR3/ABCB4 (2010)
  • Author(s): Takashi Yoshikado, Tappei Takada, Takehito Yamamoto, Hiroko Yamaji, Kousei Ito, Tomofumi Santa, Hiromitsu Yokota, Yutaka Yatomi, Haruhiko Yoshida, Jun Goto, Shoji Tsuji, Hiroshi Suzuki
  • Journal Title: Molecular Pharmacology Volume: 79(2) Pages: 241-250
  • Peer Reviewed
• [Presentation] G蛋白質制御内向き整流性K+チャネル阻害薬の探索システムと新規阻害薬の作用機構: "イオンチャネルの結晶構造に基づいた作動原理の解明と新規阻害薬の探索". (2016)
  • Author(s): Inanobe A, Kurachi Y.
  • Organizer: 第93回日本生理学会大会
  • Place of Presentation: 札幌コンベンションセンター（札幌市）
  • Year and Date: 2016-03-24
• [Presentation] Kir1.1チャネルにおける小分子結合部位の構造活性相関解析. (2016)
  • Author(s): 古谷和春, 半田健一郎, 村上洋一, 木下賢吾, 倉智嘉久.
  • Organizer: 第93回日本生理学会大会
  • Place of Presentation: 札幌コンベンションセンター（札幌市）
  • Year and Date: 2016-03-24
• [Presentation] An arrhythmic mutation modifies TRPM4 channel gating via altered PIP2 sensitivity. (2016)
  • Author(s): Yaopeng Hu, Lin Hai-Kurahara, Narumi Shioi, Keizo Hiraishi, Jun Ichikawa, Tomohiro Numata, Yasushi Okamura, Ryuji Inoue.
  • Organizer: The 93rd annual Meeting of Physiological Society of Japan.
  • Place of Presentation: Sapporo Convention Center, Sapporo
  • Year and Date: 2016-03-24
• [Presentation] A mathematical modeling of phase-2 reentry attributable to changes in subcellular expression of Nav1.5 channel. (2016)
  • Author(s): Kunichika Tsumoto, Takashi Ashihara, Narumi Naito, Akira Amano, Kazuo Nakazawa, Yoshihisa Kurachi.
  • Organizer: 第93回日本生理学会大会
  • Place of Presentation: 札幌コンベンションセンター（札幌市）
  • Year and Date: 2016-03-23
• [Presentation] Numerical model-based investigation of TRPM4 channel in cardiac remodeling-associated arrhythmogenicity. (2016)
  • Author(s): Ryuji Inoue, Yaopeng Hu, Yubin Duan, Ayako Takeuchi, Lin Hai-Kurahara, Jun Ichikawa, Satoshi Matsuoka.
  • Organizer: The 93rd annual Meeting of Physiological Society of Japan.
  • Place of Presentation: Sapporo Convention Center, Sapporo
  • Year and Date: 2016-03-23
• [Presentation] Daikenchuto ameliorates fibrotic stenosis by activating myofibroblast TRPA1 channel. (2016)
  • Author(s): Lin Kurahara, Keizo Hiraishi, Yaopeng Hu, Kunihiko Aoyagi, Ryuji Inoue.
  • Organizer: The 93rd annual Meeting of Physiological Society of Japan.
  • Place of Presentation: Sapporo Convention Center, Sapporo
  • Year and Date: 2016-03-22
• [Presentation] 特異体質性副作用発現に関与するHLAタンパク質-薬物分子の相互作用の解析. (2016)
  • Author(s): 長屋仁織, 本間雅, 苅谷嘉顕, 加藤智起, 池淵祐樹, 鈴木洋史.
  • Organizer: 日本薬学会第136年会
  • Place of Presentation: パシフィコ横浜（横浜市）
  • Year and Date: 2016-03-18
• [Presentation] 薬物によるKir1.1チャネル阻害の基盤. (2016)
  • Author(s): 古谷和春, 半田健一郎, 村上洋一, 木下賢吾, 倉智嘉久.
  • Organizer: 第89回日本薬理学会年会
  • Place of Presentation: パシフィコ横浜（横浜市）
  • Year and Date: 2016-03-10
• [Presentation] Cellular systems. (2016)
  • Author(s): Kitano H.
  • Organizer: VIZBI 2016
  • Place of Presentation: EMBL Heidelberg
  • Year and Date: 2016-03-10
  • Int'l Joint Research / Invited
• [Presentation] 不整脈原性RyR2変異のCa2+遊離特性 - カテコラミン誘発性多型性心室頻拍（CPVT）変異と特発性心室細動（I-VF）変異の比較‐. (2016)
  • Author(s): 呉林なごみ, 村山 尚, 太田亮作, 山下富義, 鈴木純二, 金丸和典, 飯野正光, 櫻井 隆.
  • Organizer: 第89回日本薬理学会年会
  • Place of Presentation: パシフィコ横浜（横浜市）
  • Year and Date: 2016-03-10
• [Presentation] Dynamical mechanism of early afterdepolarization induced by administration of class III antiarrhythmic agents. (2016)
  • Author(s): Kuncihika Tsumoto, Yasutaka Kurata, Yoshihisa Kurachi.
  • Organizer: 第89回日本薬理学会年会
  • Place of Presentation: パシフィコ横浜（横浜市）
  • Year and Date: 2016-03-09
• [Presentation] PIP2による平滑筋受容体活性化Caチャネル制御のシミュレーション解析. (2016)
  • Author(s): 井上隆司.
  • Organizer: シンポジウム「平滑筋の生理と機能」
  • Place of Presentation: ウェスティンナゴヤキャッスル（名古屋市）
  • Year and Date: 2016-03-05
  • Invited
• [Presentation] システム医科学におけるオープンイノベーションを促進するガルーダ・プラットフォーム. (2016)
  • Author(s): 北野宏明.
  • Organizer: 第23回 分子複合医薬研究会 特別シンポジウム
  • Place of Presentation: 産業総合技術研究所 関西センター（池田市）
  • Year and Date: 2016-02-26
  • Invited
• [Presentation] システム創薬とデジタルヘルスを促進するガルーダ・プラットフォーム. (2016)
  • Author(s): 北野宏明.
  • Organizer: 第10回スーパーコンピュータ「京」と創薬・医療の産学連携セミナー
  • Place of Presentation: グランフロント大阪（大阪市）
  • Year and Date: 2016-01-22
  • Invited
• [Presentation] カリウムチャネル制御Gタンパク質シグナルの電位依存性. (2015)
  • Author(s): 古谷和春, 倉智嘉久.
  • Organizer: 平成27年度筋生理の集い
  • Place of Presentation: 東京慈恵会医科大学（東京）
  • Year and Date: 2015-12-19
  • Invited
• [Presentation] A mathematical modeling of phase-2 reentry attributed to subcellular changes in the cardiac sodium channel expression. (2015)
  • Author(s): Kunichika Tsumoto, Yoshihisa Kurachi.
  • Organizer: CVMW2015心血管代謝週間(第32回国際心臓研究学会日本部会(ISHR2015))
  • Place of Presentation: 神戸国際会議場（神戸市）
  • Year and Date: 2015-12-11
• [Presentation] 生細胞ベーススクリーニングシステムによるカリウムチャネルKir3.2阻害薬の同定. (2015)
  • Author(s): 河田仁史, 稲野辺厚, 倉智嘉久.
  • Organizer: BMB2015
  • Place of Presentation: 神戸国際会議場（神戸市）
  • Year and Date: 2015-12-04
• [Presentation] 心筋ナトリウムチャネルの発現変化により生じるPhase-2リエントリー: in silico研究. (2015)
  • Author(s): 津元国親, 倉智嘉久.
  • Organizer: 第25回日本循環薬理学会
  • Place of Presentation: 東大寺総合文化センター金鐘ホール（奈良市）
  • Year and Date: 2015-12-04
• [Presentation] ガルーダ・プラットフォーム：創薬、デジタルヘルスのための革新的情報基盤システム. (2015)
  • Author(s): 北野宏明.
  • Organizer: 武田薬品―京都大学医学部附属病院合同シンポジウム: 日本におけるデジタルヘルス -現状と将来展望
  • Place of Presentation: 京都大学医学部創立百周年記念施設芝蘭会館 稲盛ホール（京都市）
  • Year and Date: 2015-12-04
  • Invited
• [Presentation] コンピューターサイエンスがもたらす薬剤学研究のイノベーション. (2015)
  • Author(s): 山下富義.
  • Organizer: 第21回創剤フォーラム若手研究会
  • Place of Presentation: 東京大学（東京）
  • Year and Date: 2015-11-28
  • Invited
• [Presentation] PhysioDesigner: A versatile platform for multilevel modeling of physiological systems network. (2015)
  • Author(s): Yoshiyuki Asai, Takeshi Abe, Hiroaki Kitano.
  • Organizer: BioNetVisA 2015 workshop
  • Place of Presentation: National University of Singapore (NUS), Singapore
  • Year and Date: 2015-11-25
  • Int'l Joint Research
• [Presentation] In-silico approach in assessing anti-influenza agents and their targets using comprehensive pathway map (FluMap). (2015)
  • Author(s): Kun-Yi Hsin, Yukiko Matsuoka, Tokiko Watanabe, Yoshihiro Kawaoka, Hiroaki Kitano.
  • Organizer: ICSB 2015
  • Place of Presentation: Biopolis, Singapore
  • Year and Date: 2015-11-23
  • Int'l Joint Research
• [Presentation] Garuda Platform for Systems Biology. (2015)
  • Author(s): Kitano H.
  • Organizer: ICSB 2015
  • Place of Presentation: Biopolis, Singapore
  • Year and Date: 2015-11-23
  • Int'l Joint Research
• [Presentation] Dysregulation of suppressor of cytokine signaling 3 in keratinocytes cause hyper-activation of Ap-1 related genes and develop hyperplasia like phenotype. (2015)
  • Author(s): Archana Bajpai, Takashi Ishii, Miyauchi Koichi, Masato Kubo, Hiroaki Kitano.
  • Organizer: ICSB 2015
  • Place of Presentation: Biopolis, Singapore
  • Year and Date: 2015-11-23
  • Int'l Joint Research
• [Presentation] システム医科学におけるオープンイノベーションを促進するガルーダ・プラットフォーム. (2015)
  • Author(s): 北野宏明.
  • Organizer: 日本薬物動態学会 第30回年会
  • Place of Presentation: タワーホール船堀（東京）
  • Year and Date: 2015-11-14
  • Invited
• [Presentation] Naチャネルの変異に伴う心室筋細胞活動電位の変化のシミュレーション. (2015)
  • Author(s): 稲田 慎, 吉田秀哉, 相庭武司, 山下富義, 中沢一雄.
  • Organizer: 第３５回医療情報学連合大会
  • Place of Presentation: 沖縄コンベンションセンター（宜野湾市）
  • Year and Date: 2015-11-03
• [Presentation] 人工知能がノーベル賞を獲る日：科学的発見のエンジンを作る. (2015)
  • Author(s): 北野宏明.
  • Organizer: 日本バイオインフォマティクス学会年会・生命医薬情報学連合大会, 一般公開シンポジウム：生命科学データベースと人工知能・ロボティクスの拓く未来
  • Place of Presentation: 京都大学宇治キャンパスおうばくプラザ（宇治市）
  • Year and Date: 2015-10-31
  • Invited
• [Presentation] 心筋細胞にみられる早期後脱分極の動的生成機序の解析. (2015)
  • Author(s): 津元国親, 倉田康孝, 倉智嘉久.
  • Organizer: 生理研研究会「心臓血管系の包括的な機能統合研究」
  • Place of Presentation: 生理学研究所（岡崎市）
  • Year and Date: 2015-10-29
• [Presentation] m2ムスカリン性アセチルコリン受容体を介したシグナル伝達の新しい制御. (2015)
  • Author(s): 古谷和春, 陳 以珊, 倉智嘉久.
  • Organizer: 日本生理学会第108回近畿生理学談話会
  • Place of Presentation: 近畿大学東大阪キャンパス（東大阪市）
  • Year and Date: 2015-10-24
• [Presentation] Simulation-based study of PIP2-meditated regulation of TRP channels based on voltage-sensing phosphatase and FRET measurements. (2015)
  • Author(s): Ryuji Inoue, Hu Yaopeng, Jun Ichikawa, Lin Kurahara, Tomohiro Numata.
  • Organizer: The 67th Annual Meeting of Korean Physiological Society
  • Place of Presentation: Pusan National University Hospital, Busan, Korea
  • Year and Date: 2015-10-23
  • Int'l Joint Research
• [Presentation] Creating Standards: Experiences from VRML, SBML, SBGN, RoboCup, and Garuda Platform. General-purpose humanoid robot utilization. (2015)
  • Author(s): 北野宏明.
  • Organizer: 汎用ヒト型ロボット活用研究会ワークショップ 「汎用ヒト型ロボット活用に向けたデータサイエンス」
  • Place of Presentation: クックパッド本社（東京）
  • Year and Date: 2015-09-05
  • Invited
• [Presentation] K+チャネル機能評価システムとオーファン輸送体. (2015)
  • Author(s): 稲野辺厚, 倉智嘉久.
  • Organizer: 生理学研究所研究会、「生体シグナルダイナミクス」
  • Place of Presentation: 生理学研究所（岡崎市）
  • Year and Date: 2015-09-04
• [Presentation] システム医科学におけるオープンイノベーションを促進するガルーダ・プラットフォーム. (2015)
  • Author(s): 北野宏明.
  • Organizer: JASIS 2015 先端診断イノベーションゾーン
  • Place of Presentation: 幕張メッセ（千葉）
  • Year and Date: 2015-09-03
  • Invited
• [Presentation] Computational Systems Toxicology Approach Using the Garuda Platform. (2015)
  • Author(s): Kitano H.
  • Organizer: nization, from Drug Exposure to Clinical PhenotypeWorkshop on Pharmacological Mechanism-Based Drug Safety Prediction
  • Place of Presentation: FDA White Oak Facility, Silver Spring, USA
  • Year and Date: 2015-08-06
  • Int'l Joint Research / Invited
• [Presentation] Prediction of TKI associated cardiotoxicity based on network analyses of intracellular signaling pathways. (2015)
  • Author(s): Kariya Y, Honma M, Suzuki H.
  • Organizer: Workshop on Pharmacological Mechanism-Based Drug Safety Prediction
  • Place of Presentation: FDA White Oak Campus, Silver Spring, MD, USA,
  • Year and Date: 2015-08-06
  • Int'l Joint Research / Invited
• [Presentation] Dynamic regulation of TRPC and TRPM4 channels by endogenous PIP2 level investigated by voltage-sensing phosphatase and FRET. (2015)
  • Author(s): Inoue R.
  • Organizer: the 50th Annual Congress of the Brazilian Society of Physiology (SBFis 2015)
  • Place of Presentation: Aquas Lindoia, San Paulo, Brazil
  • Year and Date: 2015-08-05
  • Int'l Joint Research / Invited
• [Presentation] Subcellular distribution of cardiac sodium channels associated with phase-2 reentry initiation. (2015)
  • Author(s): Kunichika Tsumoto, Yoshihisa Kurachi.
  • Organizer: 第30回日本不整脈学会学術大会・第32回日本心電学会学術集会合同学術大会
  • Place of Presentation: 国立京都国際会館・グランドプリンスホテル京都（京都市）
  • Year and Date: 2015-07-29
• [Presentation] Garuda Platform: Innovations in Computational Platform for Drug Discovery and Digital Health. (2015)
  • Author(s): 北野宏明.
  • Organizer: 第31回創薬セミナー
  • Place of Presentation: 大津プリンスホテル（大津市）
  • Year and Date: 2015-07-22
  • Invited
• [Presentation] ビタミンKの吸収不全を介したエゼチミブとワルファリンの薬物相互作用. (2015)
  • Author(s): 山梨義英, 高田龍平, 小西健太郎, 山本武人, 豊田優, 山本英明, 増尾友佑, 鈴木洋史.
  • Organizer: 第47回日本動脈硬化学会総会・学術集会
  • Place of Presentation: 仙台国際センター（仙台市）
  • Year and Date: 2015-07-09
• [Presentation] システムトキシコロジーの情報基盤としてのGaruda Platform. (2015)
  • Author(s): 北野宏明.
  • Organizer: 第42回日本毒性学会学術年会 シンポジウム：「エピゲノミクス・ゲノミクス解析の進展と適応拡大する毒性オミクス」
  • Place of Presentation: ホテル日航金沢（金沢市）
  • Year and Date: 2015-07-01
  • Invited
• [Presentation] 生細胞ベースのカリウムチャネルKir3.2阻害薬スクリーニングシステムの構築と阻害薬の同定. (2015)
  • Author(s): 河田仁史, 稲野辺厚, 倉智嘉久.
  • Organizer: 第127回日本薬理学会近畿部会
  • Place of Presentation: 長良川国際会議場（岐阜市）
  • Year and Date: 2015-06-26
• [Presentation] Simulation study on contributions of membrane permeability, metabolic clearance, and efflux transport by p-glycoprotein to intestinal availability using translocation model. (2015)
  • Author(s): Ando H, Hisaka A, Suzuki H.
  • Organizer: 13th European ISSX Meeting
  • Place of Presentation: The University of Strathclyde, Glasgow, Scotland
  • Year and Date: 2015-06-22
  • Int'l Joint Research
• [Presentation] A FRET- and simulation-based study on the PIP2-mediated regulation of TRPC3/C6/C7 subfamily channels. (2015)
  • Author(s): Inoue R, Itsuki K, Imai U, Okamura Y, Mori MX.
  • Organizer: Symposium “Multicellular Inputs Regulating Muscle Excitability”
  • Place of Presentation: Granlibakken, Lake Tahoe, California, USA
  • Year and Date: 2015-06-14
  • Int'l Joint Research / Invited
• [Presentation] Phase-2リエントリーを惹起する心臓興奮伝導モデル：細胞内ナトリウムチャネル発現分布からの予測. (2015)
  • Author(s): 津元国親, 倉智嘉久.
  • Organizer: 第35回日本ホルタ―・ノンインベイシブ心電学研究会研究会
  • Place of Presentation: コクヨホール（東京）
  • Year and Date: 2015-06-13
• [Presentation] エゼチミブとワルファリンの薬物相互作用メカニズムの解明. (2015)
  • Author(s): 山梨義英, 高田龍平, 小西健太郎, 山本武人, 豊田優, 山本英明, 増尾友佑, 鈴木洋史.
  • Organizer: 日本薬剤学会第30年会
  • Place of Presentation: 長崎ブリックホール（長崎市）
  • Year and Date: 2015-05-21
• [Presentation] Identification of NPC1L1 as a physiological vitamin K importer in the small intestine. (2015)
  • Author(s): Tappei Takada, Yoshihide Yamanashi, Kentaro Konishi, Takehito Yamamoto, Yu Toyoda, Yusuke Masuo, Hideaki Yamamoto, Yusuke Tanaka, Toko Komine, Hiroshi Suzuki.
  • Organizer: 12th Asian Congress of Nutrition
  • Place of Presentation: Pacifico Yokohama, Yokohama
  • Year and Date: 2015-05-14
  • Int'l Joint Research
• [Presentation] 心筋細胞における早期後脱分極生成機序解明のための数理解析手法の提案. (2015)
  • Author(s): 津元国親, 倉田康孝, 倉智嘉久.
  • Organizer: 第54回日本生体医工学会大会
  • Place of Presentation: 名古屋国際会議場（名古屋市）
  • Year and Date: 2015-05-09
• [Presentation] Biliary excretion of glutathione-conjugates of 1, 2-dichloropropane: potential influence on the cholangiocarcinoma risk induced by the exposure to halogenated hydrocarbon solvent. (2015)
  • Author(s): Yu Toyoda, Tappei Takada, Hiroshi Suzuki.
  • Organizer: Gordon-Kenan Research Seminar 2015 "Multi-Drug Efflux Systems" Learning from the Past to Innovate the Future
  • Place of Presentation: Lucca Barga Italy
  • Year and Date: 2015-04-25
  • Int'l Joint Research
• [Presentation] The Day AI wins the Nobel Prize. (2015)
  • Author(s): Kitano H.
  • Organizer: 1st Think X Symposium Theme: Smart Healthcare for Smart Nation
  • Place of Presentation: Infuse Theatrette at Fusionopolis, Singapore
  • Year and Date: 2015-04-09
  • Int'l Joint Research / Invited
• [Presentation] In vitro-in vivo補外予測によりin vivo動態試験のサンプリングコストを低減できるか？ (2015)
  • Author(s): 山下富義、酒井千賀、橋田充
  • Organizer: 日本薬学会第135年会
  • Place of Presentation: 神戸サンボーホール（神戸市）
  • Year and Date: 2015-03-26
  • Invited
• [Presentation] Phase-2 reentry induced from decrease in the cardiac sodium channel expression: in silico study (2015)
  • Author(s): Kunichika Tsumoto, Yoshihisa Kurachi
  • Organizer: 第120回日本解剖学会総会・全国学術集会・第92回日本生理学会大会
  • Place of Presentation: 神戸国際会議場（神戸市）
  • Year and Date: 2015-03-22
• [Presentation] ムスカリンM2受容体依存的GIRKチャネル活性化におけるパーシャルアゴニスト作用の分子機構と制御 (2015)
  • Author(s): 古谷和春、陳以珊、稲野辺厚、倉智嘉久
  • Organizer: 第120回日本解剖学会総会・全国学術集会・第92回日本生理学会大会
  • Place of Presentation: 神戸国際会議場（神戸市）
  • Year and Date: 2015-03-21
• [Presentation] m2ムスカリン性アセチルコリン受容体のRGS4を介したカリウム電流制御の膜電位依存性及び制御機構 (2015)
  • Author(s): 陳以珊、古谷和春、稲野辺厚、倉智嘉久
  • Organizer: 第120回日本解剖学会総会・全国学術集会・第92回日本生理学会大会
  • Place of Presentation: 神戸国際会議場（神戸市）
  • Year and Date: 2015-03-21
• [Presentation] Simulation analysis of water and ion dynamics in astrocyte (2015)
  • Author(s): Shingo Murakami, Yoshihisa Kurachi
  • Organizer: 第120回日本解剖学会総会・全国学術集会・第92回日本生理学会大会
  • Place of Presentation: 神戸国際会議場（神戸市）
  • Year and Date: 2015-03-21
• [Presentation] アストロサイトにおける水・イオン動態のシミュレーション解析 (2015)
  • Author(s): Shingo Murakami, Yoshihisa Kurachi
  • Organizer: 第88回日本薬理学会年会
  • Place of Presentation: 名古屋国際会議場（名古屋市）
  • Year and Date: 2015-03-20
• [Presentation] I型QT延長症候群変異体の細胞内輸送を障害する分子機構 (2015)
  • Author(s): 稲野辺厚、都築千鶴、倉智嘉久
  • Organizer: 第88回日本薬理学会年会
  • Place of Presentation: 名古屋国際会議場（名古屋市）
  • Year and Date: 2015-03-20
• [Presentation] 2 型リアノジン受容体の不整脈原性変異はCICR 活性と細胞内Ca2+動態にどのような影響を及ぼすか? (2015)
  • Author(s): 呉林なごみ、村山尚、太田亮作、山下富義、鈴木純二、金丸和典、飯野正光、櫻井隆
  • Organizer: 第88回日本薬理学会年会
  • Place of Presentation: 名古屋国際会議場（名古屋市）
  • Year and Date: 2015-03-20
• [Presentation] An ischemia-related subcellular redistribution of cardiac sodium channels related to the initiation of reentrant tachyarrhythmia (2015)
  • Author(s): Kunichika Tsumoto, Yoshihisa Kurachi
  • Organizer: 第88回日本薬理学会年会
  • Place of Presentation: 名古屋国際会議場（名古屋市）
  • Year and Date: 2015-03-19
• [Presentation] 生細胞ベースの新規機能分子探索システムによる Kir3.2 阻害薬の同定とその作用機序 (2015)
  • Author(s): 河田仁史、稲野辺厚、倉智嘉久
  • Organizer: 第88回日本薬理学会年会
  • Place of Presentation: 名古屋国際会議場（名古屋市）
  • Year and Date: 2015-03-19
• [Presentation] The Day AI Wins Nobel Prize: Toward Advanced Intelligence that Transforms the Way We do Biomedical Research (2015)
  • Author(s): Kitano H
  • Organizer: MIME-FIT Workshop: Challenges and Future Directions in Systems Medicine and Health ICT
  • Place of Presentation: Clayton Campus, Monash University (Australia)
  • Year and Date: 2015-03-19
  • Invited
• [Presentation] 細胞内シグナルネットワークを考慮したシステム薬理学的心毒性予測 (2015)
  • Author(s): 苅谷嘉顕、本間雅、鈴木洋史
  • Organizer: 第88回日本薬理学会年会
  • Place of Presentation: 名古屋国際会議場（名古屋市）
  • Year and Date: 2015-03-19
• [Presentation] 薬物動態学的相互作用の予測を目指した多階層生体モデリング (2015)
  • Author(s): 山下富義
  • Organizer: 第88回日本薬理学会年会
  • Place of Presentation: 名古屋国際会議場（名古屋市）
  • Year and Date: 2015-03-19
• [Presentation] 聴覚に必須である蝸牛 K+ 一方向性輸送の生理的構築と機能 (2015)
  • Author(s): 日比野浩、任書晃、村上 慎吾、倉智 嘉久
  • Organizer: 第88回日本薬理学会年会JPSサテライトシンポジウム１「イオンチャネルの分子的多様性とそれによる生理機能制御」
  • Place of Presentation: 名古屋国際会議場（名古屋市）
  • Year and Date: 2015-03-18
• [Presentation] RGS4 タンパク質はムスカリンM2 受容体活性化カリウム電流におけるパーシャルアゴニスト作用を制御する (2015)
  • Author(s): 陳以珊、古谷和春、稲野辺厚、倉智嘉久
  • Organizer: 第88回日本薬理学会年会
  • Place of Presentation: 名古屋国際会議場（名古屋市）
  • Year and Date: 2015-03-18
• [Presentation] Simulation-Based Approach to Understanding TRPM4-Mediated Arrhythmogenicity (2015)
  • Author(s): Ryuji Inoue
  • Organizer: The 88th annual meeting of Japanese Pharmacological Society, International Symposium on Ion channels, transporters, and small molecules as key regulators of homeostatic systems
  • Place of Presentation: Nagoya Congress Center (Nagoya, Japan)
  • Year and Date: 2015-03-18
  • Invited
• [Presentation] Intestinal myofibroblast TRPC6 channel may contribute to stenotic fi brosis in Crohn's disease (2015)
  • Author(s): Lin Kurahara, Miho Sumiyoshi, Kunihiko Aoyagi, Keizo Hiraishi, Ryuji Inoue
  • Organizer: The 88th annual meeting of Japanese Pharmacological Society
  • Place of Presentation: Nagoya Congress Center (Nagoya, Japan)
  • Year and Date: 2015-03-18
• [Presentation] Pathogenic activation of TRPC6 channel associated with familial focal segmental glomerulosclerosis (FSGS) mutations may be counteracted by the cGMP/PKG pathway through interaction with actin cytoskeleton (2015)
  • Author(s): Ichikawa J, Inoue R
  • Organizer: The 88th annual meeting of Japanese Pharmacological Society
  • Place of Presentation: Nagoya Congress Center (Nagoya, Japan)
  • Year and Date: 2015-03-18
• [Presentation] Ca2+- and voltage-dependent activation of TRPM4 channel may account for abnormal automaticity (2015)
  • Author(s): Ryuji Inoue
  • Organizer: The 92th annual meeting of Physiological Society of Japan
  • Place of Presentation: 神戸国際会議場（神戸市）
  • Year and Date: 2015-03-18
• [Presentation] Therapeutic implications of myofibroblast TRP channels for stenotic fi brosis in Crohns disease (2015)
  • Author(s): Kurahara L, Hiraishi K, Sumiyoshi M, Aoyagi K, Inoue R
  • Organizer: The 92th annual meeting of Physiological Society of Japan
  • Place of Presentation: 神戸国際会議場（神戸市）
  • Year and Date: 2015-03-18
• [Presentation] Ca2+- and Calmodulin-mediated regulation of receptor-operated cation currents of TRPC6 channels (2015)
  • Author(s): Mori MX, Hirano M, Hase H, Itsuki K, Inoue R, Mori Y
  • Organizer: The 92th annual meeting of Physiological Society of Japan
  • Place of Presentation: 神戸国際会議場（神戸市）
  • Year and Date: 2015-03-18
• [Presentation] TRPM2 protects mice against polymicrobial sepsis by enhancing bacterial clearance (2015)
  • Author(s): Numata T, Qian X, Inoue R, Fang X, Mori Y
  • Organizer: The 92th annual meeting of Physiological Society of Japan
  • Place of Presentation: 神戸国際会議場（神戸市）
  • Year and Date: 2015-03-18
• [Presentation] Involvement of podocin on abnormal receptor-response and mechanosensitivity of mutant TRPC6 channels associated with familial focal segmental glomerulosclerosis (FSGS) (2015)
  • Author(s): Ichikawa J., Inoue R
  • Organizer: The 92th annual meeting of Physiological Society of Japan
  • Place of Presentation: 神戸国際会議場（神戸市）
  • Year and Date: 2015-03-18
• [Presentation] An Essential Role of RGS Protein in Partial Agonism of the m2 Muscarinic Receptor-Mediated K+ Currents (2015)
  • Author(s): Kazuharu Furutani, Yoshihisa Kurachi
  • Organizer: International Symposium on Ion channels, transporters, and small molecules as key regulators of homeostatic systems
  • Place of Presentation: Nagoya Congress Center (Nagoya, Japan)
  • Year and Date: 2015-03-17
  • Invited
• [Presentation] The Day AI Wins Nobel Prize: Toward Advanced Intelligence that Transforms the Way We do Biomedical Research (2015)
  • Author(s): Kitano H
  • Organizer: 2015 Hunter Meeting
  • Place of Presentation: Crown Plaza Hunter Valley (Lovedale, Australia)
  • Year and Date: 2015-03-17
  • Invited
• [Presentation] Disruptive Innovation in Computational Platform for Systems Biology (2015)
  • Author(s): Kitano H
  • Organizer: Grant-in-Aid for Scientific Research on Innovative Area “HD- Physiology” The Final HD-Physiology Symposium
  • Place of Presentation: Osaka University Nakanoshima Center (Osaka, Japan)
  • Year and Date: 2015-03-06
  • Invited
• [Presentation] Dynamic regulation of TRPC and TRPM4 channels by endogenous PIP2 level (2015)
  • Author(s): Ryuji Inoue
  • Organizer: Grant-in-Aid for Scientific Research on Innovative Area “HD- Physiology” The Final HD-Physiology Symposium
  • Place of Presentation: Osaka University Nakanoshima Center (Osaka, Japan)
  • Year and Date: 2015-03-06
  • Invited
• [Presentation] Systems pharmacology: a powerful tool to analyze/predict drug actions (2015)
  • Author(s): Hiroshi Suzuki
  • Organizer: Grant-in-Aid for Scientific Research on Innovative Area “HD Physiology” The Final HD Physiology Symposium
  • Place of Presentation: 大阪大学中之島センター（大阪市）
  • Year and Date: 2015-03-06
  • Invited
• [Presentation] Molecular basis of Kir1.1 channel block (2015)
  • Author(s): Kenichiro Handa, Kazuharu Furutani, Yoichi Murakami, Kengo Kinoshita, Yoshihisa Kurachi
  • Organizer: 新学術領域研究「多階層生体機能学」最終成果報告会
  • Place of Presentation: 大阪大学中之島センター（大阪市）
  • Year and Date: 2015-03-05
• [Presentation] Proflavine Blocks G Protein-Gated Inwardly Rectifying Potassium Channels (2015)
  • Author(s): Hitoshi Kawada, Atsushi Inanobe, Yoshihisa Kurachi
  • Organizer: 新学術領域研究「多階層生体機能学」最終成果報告会
  • Place of Presentation: 大阪大学中之島センター（大阪市）
  • Year and Date: 2015-03-05
• [Presentation] LQT1 Mutations in KCNQ1 C-terminus Assembly (2015)
  • Author(s): Atsushi Inanobe, Chizuru Tsuzuki, Yoshihisa Kurachi
  • Organizer: 新学術領域研究「多階層生体機能学」最終成果報告会
  • Place of Presentation: 大阪大学中之島センター（大阪市）
  • Year and Date: 2015-03-05
• [Presentation] Voltage-dependence of RGS4-mediated regulation on the M2 muscarinic receptor-activated K+ currents (2015)
  • Author(s): I-Shan Chen, Kazuharu Furutani, Yoshihisa Kurachi
  • Organizer: 新学術領域研究「多階層生体機能学」最終成果報告会
  • Place of Presentation: 大阪大学中之島センター（大阪市）
  • Year and Date: 2015-03-05
• [Presentation] An electric field coupling theory is a novel logic to connect cardiac action potentials and excitation propagation (2015)
  • Author(s): Kunichika Tsumoto, Yoshihisa Kurachi
  • Organizer: 新学術領域研究「多階層生体機能学」最終成果報告会
  • Place of Presentation: 大阪大学中之島センター（大阪市）
  • Year and Date: 2015-03-05
• [Presentation] Simulation analysis of water and ion dynamics in astrocyte (2015)
  • Author(s): Shingo Murakami, Yoshihisa Kurachi
  • Organizer: 新学術領域研究「多階層生体機能学」最終成果報告会
  • Place of Presentation: 大阪大学中之島センター（大阪市）
  • Year and Date: 2015-03-05
• [Presentation] PhysioDesigner 1.2 (2015)
  • Author(s): Yoshiyuki Asai, Takeshi Abe, Hiroaki Kitano
  • Organizer: 新学術領域研究「多階層生体機能学」最終成果報告会
  • Place of Presentation: 大阪大学中之島センター（大阪市）
  • Year and Date: 2015-03-05
• [Presentation] Flint and Flint K3: Simulations of Biophysiological models (2015)
  • Author(s): Takeshi Abe, Yoshiyuki Asai, Masao Okita, Miho Nagai, Ken-ichi Hagihara, Hiroaki Kitano
  • Organizer: 新学術領域研究「多階層生体機能学」最終成果報告会
  • Place of Presentation: 大阪大学中之島センター（大阪市）
  • Year and Date: 2015-03-05
• [Presentation] Combining machine learning systems and multiple docking simulations for network pharmacology (2015)
  • Author(s): Kun-Yi Hsin, Yukiko Matusoka, Samik Ghosh and Hiroaki Kitano
  • Organizer: 新学術領域研究「多階層生体機能学」最終成果報告会
  • Place of Presentation: 大阪大学中之島センター（大阪市）
  • Year and Date: 2015-03-05
• [Presentation] 次世代多階層生体機能シミュレーション基盤構築と実証研究 (2015)
  • Author(s): 倉智嘉久
  • Organizer: 新学術領域研究「多階層生体機能学」最終成果報告会
  • Place of Presentation: 大阪大学中之島センター（大阪市）
  • Year and Date: 2015-03-04
  • Invited
• [Presentation] Systems Pharmacology Approach to Tyrosine Kinase Inhibitor Toxicity (2015)
  • Author(s): Hiroshi Suzuki
  • Organizer: ASCPT preconference
  • Place of Presentation: Hyatt Regency (New Orleans, LA, US)
  • Year and Date: 2015-03-03
  • Invited
• [Presentation] The day AI wins Nobel Prize (2015)
  • Author(s): Kitano H
  • Organizer: AAAI Workshop on “Beyond the Turing Test”
  • Place of Presentation: Hyatt Regency in Austin (Texas, USA)
  • Year and Date: 2015-01-25
  • Invited
• [Presentation] In-silico approach in assessing anti-influenza agents and their targets using comprehensive pathway map (FluMap) (2015)
  • Author(s): Kun-Yi Hsin, Yukiko Matsuoka and Hiroaki Kitano
  • Organizer: 4th Negative Strand Virus-Japan
  • Place of Presentation: Raguna Garden Hotel (Ginowan, Okinawa)
  • Year and Date: 2015-01-19
• [Presentation] PhysioDesignerによる多階層モデリング / Multilevel modeling by PhysioDesigner (2014)
  • Author(s): 浅井義之, 北野宏明
  • Organizer: 「ネットワークが創発する知能研究会」・「データ指向構成マイニングとシミュレーション研究会」合同秋合宿2014 / SIG-EIN & SIG-DOCMAS autumn joint conference 2014
  • Place of Presentation: OIST (Okinawa, Japan)
  • Year and Date: 2014-12-16
• [Presentation] I型QT延長症候群（LQT1）変異による細胞膜移行障害の分子機構 (2014)
  • Author(s): 稲野辺厚、都築千鶴、倉智嘉久
  • Organizer: I型QT延長症候群（LQT1）変異による細胞膜移行障害の分子機構
  • Place of Presentation: 山形テルサ（山形市）
  • Year and Date: 2014-12-05
• [Presentation] 虚血・再灌流傷害因子TRPM2の心臓における役割 (2014)
  • Author(s): 沼田朋大、清水俊一、井上隆司、森泰生
  • Organizer: 第24回日本循環薬理学会
  • Place of Presentation: 山形テルサ（山形市）
  • Year and Date: 2014-12-05
• [Presentation] 不整脈型変異E7Kが引き起こすTRPM4チャネルのPIP2感受性変化と活性亢進機構 (2014)
  • Author(s): 胡耀鵬、岡村康司、森誠之、井上隆司
  • Organizer: 第24回日本循環薬理学会
  • Place of Presentation: 山形テルサ（山形市）
  • Year and Date: 2014-12-05
• [Presentation] Molecular mechanism of partial agonism and a novel role of RGS proteinin regulation of the m2 muscarinic receptor-mediated K+ currents (2014)
  • Author(s): Kazuharu Furutani, Yoshihisa Kurachi
  • Organizer: The 45th NIPS International symposium "Cutting-edge approaches towards the functioning mechanisms”
  • Place of Presentation: Okazaki Conference center of NIPS (Okazaki, Aichi, Japan)
  • Year and Date: 2014-11-27
  • Invited
• [Presentation] Galaxyを迅速に活用するための仮想環境の構築 (2014)
  • Author(s): 芦崎晃一, 山中遼, 大田達郎, 油谷浩幸, 北野宏明
  • Organizer: 第37回日本分子生物学会年会
  • Place of Presentation: パシフィコ横浜（横浜市）
  • Year and Date: 2014-11-27
• [Presentation] 大建中湯の抗線維化・抗狭窄作用における消化管筋線維芽細胞TRPA1の役割 (2014)
  • Author(s): 倉原琳、住吉美保、青柳邦彦、平石敬三、井上隆司
  • Organizer: 第67回日本薬理学会西南部会
  • Place of Presentation: 産業医科大学（北九州市）
  • Year and Date: 2014-11-23
• [Presentation] 虚血・再灌流傷害因子TRPM2の心臓における役割 (2014)
  • Author(s): 沼田朋大、清水俊一、井上隆司、森泰生
  • Organizer: 第67回日本薬理学会西南部会
  • Place of Presentation: 産業医科大学（北九州市）
  • Year and Date: 2014-11-23
• [Presentation] 自己組織化ヘパリン誘導体の抗炎症作用と構造活性相関 (2014)
  • Author(s): 山下富義、Hasan Babazada、酒井千賀、橋田充
  • Organizer: 第42回構造活性相関シンポジウム
  • Place of Presentation: くまもと森都心プラザ （熊本市）
  • Year and Date: 2014-11-14
• [Presentation] Naチャネル遮断薬の催不整脈性と心筋Naチャネルの虚血誘発性細胞内分布変化との関係 (2014)
  • Author(s): 津元国親, 芦原貴司, 原口亮, 中沢一雄, 倉智嘉久
  • Organizer: 第126回日本薬理学会近畿部会
  • Place of Presentation: 和歌山県JAビル(和歌山市)
  • Year and Date: 2014-10-24
• [Presentation] Kinetic analysis on the PIP2 sensitivity of an arrhythmic TRPM4 channel (2014)
  • Author(s): Yaopeng Hu, Rin Kurahara, Jun Ichikawa, Yasushi Okamura, Masayuki X. Mori, Ryuji Inoue
  • Organizer: 第65回西日本生理学会
  • Place of Presentation: 琉球大学（沖縄県西原町）
  • Year and Date: 2014-10-23
• [Presentation] 血管内皮細胞におけるTRPM7発現・機能の亢進がもたらす血管障害の可能性 (2014)
  • Author(s): 平石敬三、倉原琳、住吉美保、井上隆司
  • Organizer: 第65回西日本生理学会
  • Place of Presentation: 琉球大学（沖縄県西原町）
  • Year and Date: 2014-10-23
• [Presentation] Computer-aided full-automatic construction of covariate models in population pharmacokinetic analysis (2014)
  • Author(s): Fumiyoshi Yamashita, Shuya Yoshida, Mitsuru Hashida
  • Organizer: Joint Scientific Meeting: 29th JSSX Meeting and 19th North American ISSX Meeting
  • Place of Presentation: Hilton San Francisco Union Square (San Francisco, CA, USA)
  • Year and Date: 2014-10-22
• [Presentation] Utilization of Systems-Biology in Analyzing and Predicting the Toxicity of Molecular Target Drugs (2014)
  • Author(s): Hiroshi Suzuki
  • Organizer: 19th North American ISSX Meeting / 29th JSSX Meeting
  • Place of Presentation: Hilton San Francisco (San Francisco, CA, USA)
  • Year and Date: 2014-10-21
  • Invited
• [Presentation] Garuda Platform: An integrated software solution for data-driven medical sciences (2014)
  • Author(s): Kitano H
  • Organizer: World Health Summit 2014
  • Place of Presentation: Federal Foreign Office (Berlin, Germany)
  • Year and Date: 2014-10-20
  • Invited
• [Presentation] Monitoring Protein Orientation within Oligomeric Assembly by a Split GFP Complementation (2014)
  • Author(s): 稲野辺厚、都築千鶴、倉智嘉久
  • Organizer: 第87回日本生化学会大会
  • Place of Presentation: 国立京都国際会館（京都市）
  • Year and Date: 2014-10-17
• [Presentation] A framework for simulation of neural network models driven by experimental spike timing data (2014)
  • Author(s): Yoshiyuki Asai, Hiroaki Kitano, Alessandro E.P. Villa
  • Organizer: Neural Coding 2014
  • Place of Presentation: INRA Versailles-Grignon (Versailles Cedex, France)
  • Year and Date: 2014-10-07
• [Presentation] Modeling and prediction of cytochrome P450 induction-mediated drug-drug interaction (2014)
  • Author(s): Fumiyoshi Yamashita
  • Organizer: 11th France-Japan DDS Symposium
  • Place of Presentation: 淡路夢舞台国際会議場（淡路市）
  • Year and Date: 2014-10-06
  • Invited
• [Presentation] 口腔医学におけるTRPチャネルの生理的・病態生理学的役割- overview- (2014)
  • Author(s): 井上隆司
  • Organizer: 第56回歯科基礎医学会学術大会ロッテ基金特別シンポジウム「TRPチャネルに多様な生体機能と治療標的としての展開」
  • Place of Presentation: 福岡国際会議場（福岡市）
  • Year and Date: 2014-09-27
• [Presentation] Major Points of the Revision of Japanese Guidance on Drug Interaction Studies (2014)
  • Author(s): Hiroshi Suzuki
  • Organizer: The First International Conference of Sugiyama LABORATORY
  • Place of Presentation: 日比谷コンベンションホール（東京）
  • Year and Date: 2014-09-26
  • Invited
• [Presentation] Development of multilevel neural network modeling integrating spike train data on PhysioDesigner (2014)
  • Author(s): Asai Y, Abe T, Li L, Oka H, Kurachi Y. Kitano H
  • Organizer: Advances in Neuroinformatics 2014
  • Place of Presentation: RIKEN (Wako, Saitama, Japan)
  • Year and Date: 2014-09-25
• [Presentation] RGS4-mediated regulation on the M2 muscarinic receptor-activated G-protein-gated K+ currents (2014)
  • Author(s): 陳以珊、古谷和春、稲野辺厚、倉智嘉久
  • Organizer: 生理学研究所研究会「シグナル伝達分子とその生理学的可能性」
  • Place of Presentation: 生理学研究所（岡崎市）
  • Year and Date: 2014-09-18
  • Invited
• [Presentation] Systems Biology and Applications (2014)
  • Author(s): Kitano H
  • Organizer: The 15th International Conference on Systems Biology (ICSB 2014)
  • Place of Presentation: Melbourne Convention and Exhibition Centre (Melbourne, Australia)
  • Year and Date: 2014-09-16
  • Invited
• [Presentation] Systems Drug Discovery and Software Platform (2014)
  • Author(s): Kitano H
  • Organizer: The 15th International Conference on Systems Biology (ICSB 2014)
  • Place of Presentation: Melbourne Convention and Exhibition Centre (Melbourne, Australia)
  • Year and Date: 2014-09-15
  • Invited
• [Presentation] Using molecular simulations for network pharmacology (2014)
  • Author(s): Hsin KY, Ghosh S, Kitano H
  • Organizer: EuroQSAR 2014-20th European Symposium
  • Place of Presentation: Holiday Inn St. Petersburg Moskovskye Vorota (St. Petersburg, Russia)
  • Year and Date: 2014-09-14
• [Presentation] Post-translational mechanisms for cardiovascular TRPC6 channel regulation and their physiological/pathophysiological implications (2014)
  • Author(s): Ryuji Inoue
  • Organizer: 11th International Symposium on Resistance Arteries
  • Place of Presentation: The Banff Centre (Banff, Canada)
  • Year and Date: 2014-09-07
  • Invited
• [Presentation] 心筋Na+ チャネルの細胞内分布変化による組織興奮性の低下とNa+チャネル遮断薬の催不整脈性への寄与 (2014)
  • Author(s): 津元国親, 芦原貴司, 原口亮, 中沢一雄, 倉智嘉久
  • Organizer: 生理研研究会「心血管膜輸送分子の構造・機能・病態の統合的研究戦略」
  • Place of Presentation: 生理学研究所（岡崎市）
  • Year and Date: 2014-09-04
  • Invited
• [Presentation] Interoperability between multilevel modeling platform PhysioDesigner and with databases in Physiome.jp and Dynamic Brain Platform through Garuda platform (2014)
  • Author(s): Asai Y, Kuwae K, Li L, Kitano H, Wagatsuma H, Yamaguchi Y
  • Organizer: Neuroinformatics 2014
  • Place of Presentation: Leiden (Netherlands)
  • Year and Date: 2014-08-26
• [Presentation] 血管内皮細胞におけるTRPM7発現・機能の亢進がもたらす血管障害の可能性 (2014)
  • Author(s): 平石敬三、倉原（海）琳、西村美保、洪錫欽、井上隆司
  • Organizer: 第56回日本平滑筋学会総会
  • Place of Presentation: 新横浜プリンスホテル（横浜市）
  • Year and Date: 2014-08-06
• [Presentation] 大建中湯の抗線維化狭窄作用に関わる消化管筋線維芽細胞TRPA1の分子機序 (2014)
  • Author(s): 倉原（海）琳、西村美保、青柳邦彦、平石敬三、井上隆司
  • Organizer: 第56回日本平滑筋学会総会
  • Place of Presentation: 新横浜プリンスホテル（横浜市）
  • Year and Date: 2014-08-06
• [Presentation] アストロサイトにおけるカリウムバッファリングのモデル解析 (2014)
  • Author(s): 村上慎吾、倉智嘉久
  • Organizer: 新学術領域研究「統合的多階層生体機能学領域の確立とその応用」第九回（平成26年度第一回）領域全体会議・研究報告会
  • Place of Presentation: 秋田大学（秋田市）
  • Year and Date: 2014-08-04
  • Invited
• [Presentation] 虚血境界領域における心筋細胞内Naチャネル再分布がリエントリー性心室頻拍の発生機序に関与する可能性について (2014)
  • Author(s): 津元国親、倉智嘉久
  • Organizer: 新学術領域研究「統合的多階層生体機能学領域の確立とその応用」第九回（平成26年度第一回）領域全体会議・研究報告会
  • Place of Presentation: 秋田大学（秋田市）
  • Year and Date: 2014-08-04
  • Invited
• [Presentation] Ischemia-induced subecllular sodium channel redistribution as a mechanism of arrhythmogenic effect of class-I antiarrhythmic drugs on ventricle: a simulation study (2014)
  • Author(s): Kunichika Tsumoto, Takashi Ashihara, Ryo Haraguchi, Kazuo Nakazawa, Yoshihisa Kurachi
  • Organizer: 第31回日本心電学会学術集会
  • Place of Presentation: ザ・プリンスパークタワー東京（東京都）
  • Year and Date: 2014-07-24
• [Presentation] Effects of Class III Anti-Arrhythmic Agents with hERG Channel Block and Facilitation on Cardiac Action Potential: a Simulation Study (2014)
  • Author(s): Kazuharu Furutani、Kunichika Tsumoto、I-Shan Chen、Yoshihisa Kurachi
  • Organizer: 17th World congress of basic and clinical pharmacology
  • Place of Presentation: Cape Town International Convention Centre (Cape Town, South Africa)
  • Year and Date: 2014-07-15
• [Presentation] Calml3 is a Constituent of Functional KCNQ1 Channels in the Epithelium (2014)
  • Author(s): Atsushi Inanobe, Chizuru Tsuzuki and Yoshihisa Kurachi
  • Organizer: 17th World congress of basic and clinical pharmacology
  • Place of Presentation: Cape Town International Convention Centre (Cape Town, South Africa)
  • Year and Date: 2014-07-15
• [Presentation] Fly to the future of biology (2014)
  • Author(s): Ghosh S, Kitano H
  • Organizer: ISMB 2014
  • Place of Presentation: John B. Hynes Memorial Convention Center (Boston, USA)
  • Year and Date: 2014-07-14
• [Presentation] システム毒性学の戦略とプラットフォーム技術 (2014)
  • Author(s): 北野宏明
  • Organizer: 第41回日本毒性学会学術年会シンポジウム:毒性オミクス-遺伝子発 現ネットワークを標的とした、治療、毒性、及びそれらの評価の新動向-
  • Place of Presentation: 神戸コンベンションセンター（神戸市）
  • Year and Date: 2014-07-02
  • Invited
• [Presentation] 医薬品適正使用から医薬品創成へ:分子標的薬を例として (2014)
  • Author(s): 本間 雅
  • Organizer: 医療薬学フォーラム2014/第22回クリニカルファーマシーシンポジウム
  • Place of Presentation: ビッグサイトTFTホール（東京）
  • Year and Date: 2014-06-28
  • Invited
• [Presentation] アストロサイトによるカリウム輸送のシミュレーション解析 (2014)
  • Author(s): 村上慎吾、倉智嘉久
  • Organizer: 第53回日本生体医工学会大会
  • Place of Presentation: 仙台国際センター (宮城県仙台市)
  • Year and Date: 2014-06-26
• [Presentation] Physiome.jpのモデルデータベースならびにツール連携の開発 (2014)
  • Author(s): 浅井義之, 安部武志, Li Li, 岡秀樹, 野村泰伸, 北野宏明
  • Organizer: 第53回日本生体医工学会大会
  • Place of Presentation: 仙台国際センター（宮城県仙台市）
  • Year and Date: 2014-06-26
• [Presentation] PhysioDesignerによる多階層生体機能モデリングサポート技術の進展 (2014)
  • Author(s): 浅井義之, 安部武志, Li Li, 岡秀樹, 倉智嘉久, 北野宏明
  • Organizer: 第53回日本生体医工学会大会
  • Place of Presentation: 仙台国際センター (宮城県仙台市)
  • Year and Date: 2014-06-25
• [Presentation] 2次元心筋組織モデル構築と興奮伝播シミュレーション (2014)
  • Author(s): 津元国親, 倉智嘉久
  • Organizer: 第53回日本生体医工学会大会
  • Place of Presentation: 仙台国際センター (宮城県仙台市)
  • Year and Date: 2014-06-25
• [Presentation] RGS4はムスカリンM2受容体依存的GIRKチャネル活性化におけるパーシャルアゴニスト作用を制御する (2014)
  • Author(s): 陳以珊, 古谷和春, 稲野辺厚, 倉智嘉久
  • Organizer: 第125回日本薬理学会近畿部会
  • Place of Presentation: 岡山コンベンションセンター（岡山市）
  • Year and Date: 2014-06-20
• [Presentation] 多階層生体機能学領域overview (2014)
  • Author(s): 倉智嘉久
  • Organizer: 多階層生体機能学 HD Physiologyシンポジウム
  • Place of Presentation: グランフロント大阪ナレッジキャピタルコングレコンベンションセンター（大阪市）
  • Year and Date: 2014-06-14
  • Invited
• [Presentation] 多階層生体機能学のさらなる発展 (2014)
  • Author(s): 北野宏明
  • Organizer: 多階層生体機能学シンポジウム
  • Place of Presentation: グランフロント大阪ナレッジキャピタルコングレコンベンションセンター（大阪市）
  • Year and Date: 2014-06-14
  • Invited
• [Presentation] 小分子体内循環ホメオスタシスの多階層的理解と臨床応用にむけて (2014)
  • Author(s): 鈴木洋史
  • Organizer: 文部科学省 新学術領域研究「多階層生体機能学 HD Physiology」シンポジウム 多階層生体機能学のさらなる発展 ～未病・予防・予測医学実現に向けて～
  • Place of Presentation: グランフロント大阪ナレッジキャピタルコングレコンベンションセンター（大阪市）
  • Year and Date: 2014-06-14
  • Invited
• [Presentation] クローン病線維化狭窄の病態形成におけるTRPチャネルの役割 (2014)
  • Author(s): 倉原（海）琳、住吉美保、青柳邦彦、平石敬三、井上隆司
  • Organizer: 第10回TRPチャネル研究会
  • Place of Presentation: 生理学研究所（岡崎市）
  • Year and Date: 2014-06-05
• [Presentation] TRPC6による膜電位調節が骨髄間質細胞のストア依存性Ca2+流入と細胞周期進行を制御する (2014)
  • Author(s): 市川純、井上隆司
  • Organizer: 第10回TRPチャネル研究会
  • Place of Presentation: 生理学研究所（岡崎市）
  • Year and Date: 2014-06-05
• [Presentation] フィジオームを指向した階層的モデリング／シミュレーション基盤 (2014)
  • Author(s): 浅井義之, 安部武志, 北野宏明
  • Organizer: 日本薬剤学会第29年会
  • Place of Presentation: 大宮ソニックシティビル（さいたま市）
  • Year and Date: 2014-05-22
  • Invited
• [Presentation] Mutagenic and post-translational modifications of the mechanosensitivity of reno-cardiovascular TRPC6 channel (2014)
  • Author(s): Inoue R, Jian Z, Ichikawa J, Nakagawa M, Kurahara L, Hu Y
  • Organizer: The 2nd International Symposium of Mechanobiology
  • Place of Presentation: Okayama University Junko Fukutake Hall (Okayama, Japan)
  • Year and Date: 2014-05-22
  • Invited
• [Presentation] PhysioDesigner & Flint (2014)
  • Author(s): 浅井義之, 安部武志, 李俐, 北野宏明
  • Organizer: 第２回 PhysioDesigner チュートリアル
  • Place of Presentation: 大阪大学中之島センター（大阪市）
  • Year and Date: 2014-04-25
  • Invited
• [Presentation] Multiscale disease systems modelling (2014)
  • Author(s): Kitano H
  • Organizer: 7th Noordwijkerhout Symposium on Pharmacokinetics, Pharmacodynamics and Systems Pharmacology: “SYSTEMS PHARMACOLOGY IN DRUG DISCOVERY AND DEVELOPMENT”
  • Place of Presentation: NH Conference Centre Leeuwenhorst, Noordwijkerhout (the Netherlands)
  • Year and Date: 2014-04-24
  • Invited
• [Presentation] Frontiers of Systems Biology and Software Platform (2014)
  • Author(s): Kitano H
  • Organizer: Seminar at L’OREAL Research & Innovation
  • Place of Presentation: L’OREAL Research & Innovation (Aulnay-sous-Bois, France)
  • Year and Date: 2014-04-22
• [Presentation] Pk-pd analysis of mechanism of toxicity of molecular target drugs: towards optimal treatment of cancer (2014)
  • Author(s): Hiroshi Suzuki
  • Organizer: 5th FIP Pharmaceutical Sciences World Congress (PSWC)
  • Place of Presentation: Melbourne Convention and Exhibition Centre (Melbourne, Australia)
  • Year and Date: 2014-04-14
  • Invited
• [Presentation] 虚血境界域における細胞内Naチャネル分布リモデリングがNaチャネル遮断薬による催不整脈作用に関与する可能性について (2014)
  • Author(s): 津元 国親、芦原 貴司、原口 亮、中沢 一雄、倉智 嘉久
  • Organizer: 第87回日本薬理学会年会
  • Place of Presentation: 仙台国際センター(宮城)
• [Presentation] hERG channel facilitation prevents hazardous prolongation of cardiac action potential durations (2014)
  • Author(s): Kazuharu Furutani, Kunichika Tsumoto, Yoshihisa Kurachi
  • Organizer: 第87回日本薬理学会年会
  • Place of Presentation: 仙台国際センター(宮城)
• [Presentation] アストロサイトにおけるカリウム緩衝機能のモデル解析 (2014)
  • Author(s): Shingo Murakami, Yoshihisa Kurachi
  • Organizer: 第87回日本薬理学会年会
  • Place of Presentation: 仙台国際センター(宮城)
• [Presentation] Safety Mechanism of hERG-Targeting Class III Antiarrhythmic Agents (2014)
  • Author(s): Kazuharu Furutani, Kunichika Tsumoto, Yoshihisa Kurachi
  • Organizer: 第91回日本生理学会大会
  • Place of Presentation: 鹿児島大学郡元キャンパス（鹿児島）
• [Presentation] アストロサイトのカリウム緩衝機能のモデル解析 (2014)
  • Author(s): Shingo Murakami, Yoshihisa Kurachi
  • Organizer: 第91回日本生理学会大会
  • Place of Presentation: 鹿児島大学郡元キャンパス（鹿児島）
• [Presentation] 虚血境界域におけるNaチャネルの細胞内リモデリングがリエントリー性心室頻拍の機序に関与する可能性について (2014)
  • Author(s): 津元 国親、芦原 貴司、原口 亮、中沢 一雄、倉智 嘉久
  • Organizer: 第91回日本生理学会大会
  • Place of Presentation: 鹿児島大学郡元キャンパス（鹿児島）
• [Presentation] ムスカリンM2受容体依存的GIRKチャネル活性化におけるパーシャルアゴニスト作用の分子機構 (2014)
  • Author(s): 陳 以珊、古谷 和春、稲野辺 厚、倉智 嘉久
  • Organizer: 新学術領域研究「多階層生体機能学」第六回班会議
  • Place of Presentation: 京都大学薬学部記念講堂（京都）
  • Invited
• [Presentation] システム・バイオロジーの展開と今後の可能性 (2014)
  • Author(s): 北野宏明
  • Organizer: 第75回冠循環談話会
  • Place of Presentation: 東京国際フォーラム（東京）
  • Invited
• [Presentation] Systems Drug Design and Software Platform for Adverse Drug Effects: Application to TKI Cardiotoxicity (2014)
  • Author(s): Hiroaki Kitano
  • Organizer: American Society for Clinical Pharmacology and Therapeutics (ASCPT) 2014 Annual Meeting
  • Place of Presentation: Marriott Marquis (Atlanta, Georgia, USA)
  • Invited
• [Presentation] Garuda platformを介したDynamic Brain platformとモデリング開発・シミュレーション環境をつなぐ連携システム開発 (2014)
  • Author(s): 浅井義之、桑江健、北野宏明、我妻広、山口陽子
  • Organizer: ニューロコンピューティング研究会
  • Place of Presentation: 九州工業大学（福岡）
• [Presentation] Altered PIP2 sensitivity may underlie the arrhythmogenicity of mutant TRPM4 channel (2014)
  • Author(s): Ryuji Inoue, Hu Yaopeng, Yasushi Okamura, Masayuki X Mori
  • Organizer: 第87回日本薬理学会年会シンポジウム S3B-35 “Recent progress in the study of regulation of transmembrane protein by PIP2”
  • Place of Presentation: 仙台国際センター(宮城)
• [Presentation] 神経疾患の治療を目的とした新規TRPCチャネル活性化剤の開発 (2014)
  • Author(s): 澤村晴志朗、波多野雅彦、高田宜則、桑村昂志、沼田朋大、清中茂樹、日の恭介、川村哲也、谷川潤、中川拓士、永田龍、井上隆司、森泰生
  • Organizer: 第87回日本薬理学会年会
  • Place of Presentation: 仙台国際センター(宮城)
• [Presentation] Reno-pathogenic mutations and PKG-mediated phosphorylation alter TRPC6 mechanosensitivity (2014)
  • Author(s): Ryuji Inoue, Jun Ichikawa, Midori Nakagawa, Rin Kurahara, Yaopeng Hu
  • Organizer: 第91回日本生理学会大会KPS-PSJ symposium (FAOPS Joint Symposium) “Mechanosensitive regulation of biological function: update”
  • Place of Presentation: 鹿児島大学郡元キャンパス（鹿児島）
• [Presentation] 家族性熱性けいれんにて発見されたHCNチャネル遺伝子変異の機能解析 (2014)
  • Author(s): 中村友紀、石秀玉、沼田朋第、森泰生、井上隆司、廣瀬伸一
  • Organizer: 第91回日本生理学会大会
  • Place of Presentation: 鹿児島大学郡元キャンパス（鹿児島）
• [Presentation] cGMP依存性キナーゼとTRPC6チャネルの相互作用に関する構造機能相関の解析 (2014)
  • Author(s): 本田啓、井上隆司
  • Organizer: 第91回日本生理学会大会
  • Place of Presentation: 鹿児島大学郡元キャンパス（鹿児島）
• [Presentation] 大建中湯の抗線維化狭窄作用に果たす消化管線維芽細胞TRPA1の役割 (2014)
  • Author(s): 住吉美保、倉原琳、洪錫欽、青柳邦彦、井上隆司
  • Organizer: 第91回日本生理学会大会
  • Place of Presentation: 鹿児島大学郡元キャンパス（鹿児島）
• [Presentation] PI(4,5)P2-DAGシグナルによって制御されるPLC共役型TRPC電流のモデルシミュレーション (2014)
  • Author(s): 森誠之、斎郷平、今井裕子、岡村康司、井上隆司、長谷英治、森泰生
  • Organizer: 第91回日本生理学会大会
  • Place of Presentation: 鹿児島大学郡元キャンパス（鹿児島）
• [Presentation] Enhanced PIP2 sensitivity of human TRPM4 channel with an arrhythmic mutation (2014)
  • Author(s): Hu Yaopeng, Rin Kurahara, Yasushi Okamura, Masayuki Mori, Ryuji Inoue
  • Organizer: 第91回日本生理学会大会・シンポジウム25 Pathophysiological roles of TRPM subfamily in stressed heart
  • Place of Presentation: 鹿児島大学郡元キャンパス（鹿児島）
• [Presentation] Significant contribution of TRPC6-mediated Ca2+ influx to the pathogenesis of Crohn’ s disease fibrotic stenosis (2014)
  • Author(s): Lin Hai Kurahara, Miho Sumiyoshi, Hsichin Hung, Kunihiko Aoyagi, Ryuji Inoue
  • Organizer: 第91回日本生理学会大会・シンポジウム31 Pathophysiology for immunity-related gastrointestinal dysfunctions
  • Place of Presentation: 鹿児島大学郡元キャンパス（鹿児島）
• [Presentation] The roles of STIM/Orai and TRPC1/C6 channels in cell cycle progression of bone marrow stromal cells (2014)
  • Author(s): Jun Ichikawa, Ryuji Inoue
  • Organizer: 第91回日本生理学会大会・シンポジウム4 Role of STIM/Orai for physiological function
  • Place of Presentation: 鹿児島大学郡元キャンパス（鹿児島）
• [Presentation] 分子標的薬の毒性発症機構の解析 (2014)
  • Author(s): 鈴木洋史、本間雅
  • Organizer: 第91回日本生理学会大会・大会企画シンポジウム フィジオーム・システムズバイオロジー研究の現状と課題
  • Place of Presentation: 鹿児島大学郡元キャンパス（鹿児島）
  • Invited
• [Presentation] ムスカリンM2受容体依存的GIRKチャネル活性化におけるパーシャルアゴニスト作用の分子機構 (2013)
  • Author(s): 陳 以珊、古谷 和春、稲野辺 厚、倉智 嘉久
  • Organizer: 平成25年度筋生理の集い
  • Place of Presentation: 東京慈恵会医科大学高木会館（東京）
  • Invited
• [Presentation] The role of RGS4 in partial agonism of the m2 muscarinic receptor-activated K＋ currents (2013)
  • Author(s): 陳 以珊、古谷 和春、稲野辺 厚、倉智 嘉久
  • Organizer: 第23回日本循環薬理学会
  • Place of Presentation: 福岡大学メディカルホール（福岡）
• [Presentation] 心筋Naチャネルの細胞内分布リモデリングがNaチャネル遮断薬による催不整脈性の機序に関与する可能性について：シミュレーション研究 (2013)
  • Author(s): 津元国親、倉智嘉久
  • Organizer: 生理研研究会「心血管膜輸送分子の構造・機能・病態の統合的研究戦略」
  • Place of Presentation: 生理学研究所（愛知）
  • Invited
• [Presentation] アストロサイトによるカリウム緩衝機能のシミュレーション解析 (2013)
  • Author(s): 村上 慎吾、倉智 嘉久
  • Organizer: 第106回近畿生理学談話会
  • Place of Presentation: 奈良県立医科大学（奈良）
• [Presentation] アストロサイトによるカリウム緩衝機能のシミュレーション解析 (2013)
  • Author(s): 村上 慎吾、倉智 嘉久
  • Organizer: 第124回日本薬理学会近畿部会
  • Place of Presentation: 京都ガーデンパレス（京都）
• [Presentation] 虚血心筋における細胞内Naチャネル分布リモデリングのI群抗不整脈薬による催不整脈増強作用 (2013)
  • Author(s): 津元国親、芦原貴司、原口亮、中沢一雄、倉智嘉久
  • Organizer: 第30回日本心電学会学術集会
  • Place of Presentation: リンクステーションホール青森・ホテル青森（青森）
• [Presentation] ムスカリンM2受容体依存的GIRKチャネル活性化におけるパーシャルアゴニスト作用の分子機構 (2013)
  • Author(s): 陳 以珊、古谷 和春、稲野辺 厚、倉智 嘉久
  • Organizer: 生理学研究所研究会「新規シグナル伝達分子とその生理学的可能性」
  • Place of Presentation: 生理学研究所（愛知）
  • Invited
• [Presentation] A Versatile Platform for Multilevel Modeling of Physiological Systems: SBML-PHML Hybrid Modeling and Simulation (2013)
  • Author(s): Yoshiyuki Asai, Takeshi Abe, Hideki Oka, Masao Okita, Ken-ichi Hagihara, Samik Ghosh, Yukiko Matsuoka, Yoshihisa Kurachi, Taishin Nomura, Hiroaki Kitano
  • Organizer: 生体医工学シンポジウム
  • Place of Presentation: 九州大学伊都キャンパス（福岡）
  • Invited
• [Presentation] PhysioDesigner and Flint: a platform for multilevel modeling of physiological systems and simulation (2013)
  • Author(s): Yoshiyuki Asai, Takeshi Abe, Hideki Oka, Masao Okita, Yomohiro Okuyama, Ken-ichi Hagihara, Yoshihisa Kurachi, Hiroaki Kitano
  • Organizer: V International Conference on Computational Bioengineering (ICCB2013)
  • Place of Presentation: old Burgundian university town (Leuven, Belgium)
• [Presentation] Multilevel modeling using SBML and PHML on PhysioDesigner (2013)
  • Author(s): Yoshiyuki Asai, Takeshi Abe, Hideki Oka, Yukiko Matsuoka, Ghosh Samik, Yoshihisa Kurachi, Hiroaki Kitano
  • Organizer: The 14th International Conference on Systems Biology (ICSB2013)
  • Place of Presentation: Tivoli Congress Center (Copenhagen, Denmark)
• [Presentation] PhysioDesigner for Multilevel Neural System Modeling (2013)
  • Author(s): Yoshiyuki Asai, Hideki Oka, Li Li, Takeshi Abe, Yoshihisa Kurachi and Hiroaki Kitano
  • Organizer: Neuroinformatics2013
  • Place of Presentation: Karolinska Institutet（Stockholm, Sweden）
• [Presentation] Effects of muscarinic agonists and RGS4 on voltage-dependent responses of cardiac g protein-gated potassium currents (2013)
  • Author(s): I-Shan Chen, Kazuharu Furutani, Atsushi Inanobe, and Yoshihisa Kurachi
  • Organizer: 37th Congress of International Union of Physiological Sciences (IUPS2013)
  • Place of Presentation: Birmingham ICC (Birmingham, UK)
• [Presentation] Effects of Class III Anti-Arrhythmic Agents with hERG Channel Block and Facilitation on Cardiac Action Potential: a Simulation Study (2013)
  • Author(s): Kazuharu Furutani, Kunichika Tsumoto, I-Shan Chen and Yoshihisa Kurachi
  • Organizer: 37th Congress of International Union of Physiological Sciences (IUPS2013)
  • Place of Presentation: Birmingham ICC (Birmingham, UK)
• [Presentation] Ischemia-induced subcellular remodeling of sodium channels as a mechanism of ventricular proarrhythmia by class-I antiarrhythmic drug (2013)
  • Author(s): Kunichika Tsumoto, Takashi Ashihara, Ryo Haraguchi, Kazuo Nakazawa, Yoshihisa Kurachi
  • Organizer: 37th Congress of International Union of Physiological Sciences (IUPS2013)
  • Place of Presentation: Birmingham ICC (Birmingham, UK)
• [Presentation] Simulation of excitation propagation in the novel brick-wall model of ventricular myocardium (2013)
  • Author(s): Kunichika Tsumoto, Takashi Ashihara, Ryo Haraguchi, Kazuo Nakazawa, Yoshihisa Kurachi
  • Organizer: The 35th Annual International IEEE EMBS Conference
  • Place of Presentation: Osaka International Convention Center (Osaka, Japan)
• [Presentation] A versatile platform for multilevel modeling of physiological systems: Template/instance framework for large-scale modeling and simulation (2013)
  • Author(s): Yoshiyuki Asai, Takeshi Abe, Hideki Oka, Masao Okita, Yomohiro Okuyama, Ken-ichi Hagihara, Ghosh Samik, Yukiko Matsuoka, Yoshihisa Kurachi, Hiroaki Kitano
  • Organizer: 35th Annual International Conference of the IEEE Engineering in Medicine and Biology Society (EMBS)
  • Place of Presentation: Osaka International Convention Center (Osaka, Japan)
• [Presentation] Effects of Class III Anti-Arrhythmic Agents with hERG Channel Block and Facilitation on Cardiac Action Potential -a Simulation Study- (2013)
  • Author(s): Kazuharu Furutani, Kunichika Tsumoto, I-Shan Chen and Yoshihisa Kurachi
  • Organizer: The 2nd HD Physiology International Symposium
  • Place of Presentation: 丸の内MY PLAZA HALL（東京）
• [Presentation] Flint K3: Cloud-based simulation service powered by Flint (2013)
  • Author(s): Yoshiyuki Asai, Takeshi Abe, Masao Okita, Tomohiro Okuyama, Hagihara Ken-ichi, Yoshihisa Kurachi, Hiroaki Kitano
  • Organizer: The 2nd HD Physiology International Symposium
  • Place of Presentation: 丸の内MY PLAZA HALL（東京）
  • Invited
• [Presentation] Current Status and Perspectives on Systems Drug Discovery/システム創薬の現状と今後の展望 (2013)
  • Author(s): 北野宏明
  • Organizer: アスビオファーマ社内セミナー
  • Place of Presentation: アスビオファーマ株式会社（兵庫）
  • Invited
• [Presentation] 多階層生体機能学：モデル創薬から臨床推論サポートまで (2013)
  • Author(s): 北野宏明
  • Organizer: 金沢医科大学 第15回KMU研究推進セミナー
  • Place of Presentation: 金沢医科大学病院（石川）
  • Invited
• [Presentation] Systems Drug Discovery and Integrated Software Platform (2013)
  • Author(s): Hiroaki Kitano
  • Organizer: Talk at ETH Zurich IMSB
  • Place of Presentation: ETH Zurich IMSB (Zurich, Switzerland)
  • Invited
• [Presentation] Systems Biology Platform for Drug Discovery (2013)
  • Author(s): Hiroaki Kitano
  • Organizer: Talk at Imperial College
  • Place of Presentation: Imperial College (London, UK)
  • Invited
• [Presentation] HD-Physiology Project -A Japanese Flagship Physiological Modeling Project- (2013)
  • Author(s): Hiroaki Kitano
  • Organizer: ICSU bio-unions satellite symposium: Multi-Scale Systems Biology
  • Place of Presentation: Chicheley Hall (Chicheley, UK)
  • Invited
• [Presentation] Systems biology and systems biomedicine: integrative systems sciences and biomedical sciences (2013)
  • Author(s): Hiroaki Kitano
  • Organizer: 35th Annual International Conference of the IEEE Engineering in Medicine and Biology Society
  • Place of Presentation: Osaka International Convention Center (Osaka, Japan)
  • Invited
• [Presentation] HD-Physiology Project -A Japanese Flagship Physiological Modeling Project- (2013)
  • Author(s): Hiroaki Kitano
  • Organizer: The 2nd HD Physiology International Symposium: Multi-Level Systems Biology
  • Place of Presentation: Marunouchi MY PLAZA HALL (Tokyo Japan)
• [Presentation] PIP2によるTRPM4チャネルの制御機構－催不整脈性変異体を手がかりとした解析 (2013)
  • Author(s): 胡耀鵬、段玉斌、倉原琳、市川純、井上隆司
  • Organizer: 第23回日本循環薬理学会
  • Place of Presentation: 福岡大学メディカルホール（福岡）
• [Presentation] PIP2によるTRPM4チャネルの制御機構－催不整脈性変異体を手がかりとした解析 (2013)
  • Author(s): 胡耀鵬、岡村康司、森誠之、井上隆司
  • Organizer: 生理研研究会「心血管膜輸送分子の構造・機能・病態の統合的研究戦略」
  • Place of Presentation: 生理学研究所（愛知）
• [Presentation] 骨髄間質細胞の細胞周期制御におけるTRPC1/C6及びSTIM/Oraiの役割 (2013)
  • Author(s): 市川純、井上隆司
  • Organizer: 第64回西日本生理学会
  • Place of Presentation: 産業医科大学ラマツィーニホール（福岡）
• [Presentation] 大建中湯が消化管筋線維芽細胞TRPA1の発現・機能に及ぼす影響 (2013)
  • Author(s): 倉原琳、住吉美保、青柳邦彦、井上隆司
  • Organizer: 第64回西日本生理学会
  • Place of Presentation: 産業医科大学ラマツィーニホール（福岡）
• [Presentation] 催不整脈性遺伝子変異によるTRPM4チャネルPIP2感受性の変化 (2013)
  • Author(s): 胡耀鵬、岡村康司、森誠之、井上隆司
  • Organizer: 第64回西日本生理学会
  • Place of Presentation: 産業医科大学ラマツィーニホール（福岡）
• [Presentation] 新しい形質膜Ca2+ チャネル群TRP蛋白質を標的とした創薬可能性とその問題点 (2013)
  • Author(s): 井上隆司
  • Organizer: 第33回日本眼薬理学会
  • Place of Presentation: 京王プラザホテル（東京）
  • Invited
• [Presentation] 新しい不整脈基質候補分子TRPM4チャネルの催不整脈性の定量的検討 (2013)
  • Author(s): 井上隆司
  • Organizer: 京都大学学際融合教育研究推進センター先端医工学研究ユニット交流会
  • Place of Presentation: 京都大学桂キャンパス船井哲良記念講堂（京都）
  • Invited
• [Presentation] Arrhythmic contribution of upregulated TRPM4 channel activity in stressed cardiomyocytes (2013)
  • Author(s): Ryuji Inoue, Yaopeng Hu, Yubin Duan, Kurahara Lin, Jun Ichikawa
  • Organizer: The 11th Korea-Japan Joint Symposium of Brain Sciences, Cardiac and Smooth Muscle Sciences
  • Place of Presentation: Hamamatsu University School of Medicine （浜松）
• [Presentation] 心血管障害とTRPチャネル‐治療標的としての可能性 (2013)
  • Author(s): 井上隆司
  • Organizer: 生体機能と創薬シンポジウム2013
  • Place of Presentation: 九州大学百年講堂（福岡）
• [Presentation] ホスホイノシチドと連動するTRPC電流のキネティクス解析 (2013)
  • Author(s): 井上隆司
  • Organizer: 第55回日本平滑筋学会シンポジウムＳ１「ホスホイノシチド代謝に連関した平滑筋機能制御：最近の動向」
  • Place of Presentation: 旭川市大雪クリスタルホール（北海道）
• [Presentation] A new experimental approach reveals a high Ca2+ sensitivity of TRPM4 channel and its significant implications in arrhythmogenicity (2013)
  • Author(s): Ryuji Inoue, Yaopeng Hu, Yubin Duan, Kurahara Lin, Jun Ichikawa
  • Organizer: 37th Congress of International Union of Physiological Sciences (IUPS2013)
  • Place of Presentation: Birmingham ICC (Birmingham, UK)
• [Presentation] 細胞内Ca動態を介した心血管機能調節とその異常 －TRPチャネルを巡る話題を中心にー (2013)
  • Author(s): 井上隆司
  • Organizer: 島根大学医学部セミナー
  • Place of Presentation: 島根大学医学部（島根）
  • Invited
• [Presentation] Ca2+依存性カルモジュリンキナーゼIIによるリン酸化を介した心血管TRPC6チャネル制御の分子基盤 (2013)
  • Author(s): 井上隆司
  • Organizer: 第９回TRPチャネル研究会―TRPチャネル研究を通じて見えてきた新たな生理学の光－
  • Place of Presentation: 岡崎コンファレンスセンター（愛知）
  • Invited
• [Presentation] TRP蛋白質を標的とした新しい心血管病治療薬創出の可能性と問題点 (2013)
  • Author(s): 井上隆司
  • Organizer: 和歌山県立医科大学セミナー
  • Place of Presentation: 和歌山県立医科大学（和歌山）
  • Invited
• [Presentation] ABCG2/BCRP dysfunction as a major risk factor of gout (2013)
  • Author(s): Tappei Takada, Hirotaka Matsuo, Kimiyoshi Ichida, Akiyoshi Nakayama, Hiroshi Suzuki
  • Organizer: BioMedical Transporters 2013
  • Place of Presentation: Hotel Laudinella (St. Moritz, Switzerland)
  • Invited
• [Presentation] Dysfunction of a urate exporter ABCG2 as a major risk factor of hyperuricemia and gout (2013)
  • Author(s): Tappei Takada, Kimiyoshi Ichida, Hirotaka Matsuo, Akiyoshi Nakayama, Hiroshi Suzuki
  • Organizer: 15th International Symposium on Purine and Pyrimidine Metabolism in Man
  • Place of Presentation: Hotel Velazquez (Madrid, Spain)
• [Presentation] Utilization of machine learning techniques to pursue automatic PPK modeling (2013)
  • Author(s): Fumiyoshi Yamashita
  • Organizer: 2013 PAGJA-PAGK Joint Annual Meeting
  • Place of Presentation: Grand Hilton Seoul (Seoul, Korea)
• [Presentation] 情報科学的アプローチによる薬物動態の予測 (2013)
  • Author(s): 山下富義
  • Organizer: 第57回日本薬学会関東支部大会
  • Place of Presentation: 帝京大学（東京）
• [Presentation] 多階層生体機能モデリング・シミュレーションプラットフォームを利用した酵素誘導型薬物間相互作用シミュレータの開発 (2013)
  • Author(s): 山下富義、笹 友香子、吉田秀哉、樋坂章博、浅井義之、北野宏明、橋田 充、鈴木洋史
  • Organizer: 第29回Population Pharmacokinetics研究会
  • Place of Presentation: 慶應義塾大学日吉キャンパス協生館藤原洋記念ホール（神奈川）
• [Presentation] 遺伝的数式プログラミング法を用いたCYP3A4阻害活性に対する構造活性相関解析 (2013)
  • Author(s): 吉田秀哉、藤田淳人、山下富義、橋田 充
  • Organizer: 日本薬物動態学会第28回年会
  • Place of Presentation: タワーホール船堀（東京）
• [Presentation] Impact and application of data mining in ADME researches (2013)
  • Author(s): 山下富義
  • Organizer: 日本薬物動態学会第28回年会
  • Place of Presentation: タワーホール船堀（東京）
• [Presentation] Automated information extraction and structure-activity relationship analysis of cytochrome P450 substrates (2013)
  • Author(s): Fumiyoshi Yamashita
  • Organizer: 9th Retrometabolism Based Drug Design and Targeting Conference
  • Place of Presentation: The Villas of Grand Cypress Orlando (Orlando)
• [Presentation] アストロサイトのカリウム緩衝機能のモデル解析 (2013)
  • Author(s): 村上慎吾、倉智嘉久
  • Organizer: 平成24年度科学研究費補助金・新学術領域研究「多階層生体機能学」第6回全体会議
  • Place of Presentation: 沖縄科学技術大学院大学（沖縄県）
  • Invited
• [Presentation] 虚血誘発性細胞内NaチャネルリモデリングによるI群抗不整脈薬の催不整脈作用の増強 (2013)
  • Author(s): 津元国親、芦原貴司、原口 亮、中沢一雄、倉智嘉久
  • Organizer: 平成24年度科学研究費補助金・新学術領域研究「多階層生体機能学」第6回全体会議
  • Place of Presentation: 沖縄科学技術大学院大学（沖縄県）
  • Invited
• [Presentation] 抗不整脈薬のhERGファシリテーション作用：分子機序と不整脈治療における意義 (2013)
  • Author(s): 古谷和春、津元国親、陳 以珊、倉智嘉久
  • Organizer: 平成24年度科学研究費補助金・新学術領域研究「多階層生体機能学」第6回全体会議
  • Place of Presentation: 沖縄科学技術大学院大学（沖縄県）
  • Invited
• [Presentation] アセチルコリン感受性カリウム電流におけるshort term desensitization のシミュレーション解析 (2013)
  • Author(s): 村上慎吾、稲野辺厚、倉智嘉久
  • Organizer: 平成24年度科学研究費補助金・新学術領域研究「多階層生体機能学」第6回全体会議
  • Place of Presentation: 沖縄科学技術大学院大学（沖縄県）
  • Invited
• [Presentation] 心筋Brick wall 2D model構築とシミュレーション (2013)
  • Author(s): 津元国親，芦原貴司，原口 亮，稲田 慎，中沢一雄，倉智嘉久
  • Organizer: 平成24年度科学研究費補助金・新学術領域研究「多階層生体機能学」第6回全体会議
  • Place of Presentation: 沖縄科学技術大学院大学（沖縄県）
  • Invited
• [Presentation] Sphingolipid signaling modulates Kir channels functions (2013)
  • Author(s): Kazuharu Furutani, Yoshihisa Kurachi
  • Organizer: Cespi Nagoya Symposium - Frontiers in Structural Physiology
  • Place of Presentation: 名古屋大学豊田講堂（愛知県）
• [Presentation] Effects of block and facilitation of HERG channel by class III anti-arrhythmic agents on cardiac action potential: a simulation study (2013)
  • Author(s): 古谷和春、津元国親、倉智嘉久
  • Organizer: 第77回日本循環器学会学術集会
  • Place of Presentation: パシフィコ横浜（神奈川県）
• [Presentation] Facilitation of hERG channel by Class III anti-arrhythmic agents: the Molecular Mechanism and Therapeutic Significance (2013)
  • Author(s): 古谷和春、津元国親、陳以珊、倉智嘉久
  • Organizer: 第86回日本薬理学会年会
  • Place of Presentation: 福岡国際会議場（福岡県）
• [Presentation] アセチルコリン感受性カリウム電流の短期脱感作のモデル解析 (2013)
  • Author(s): 村上慎吾、稲野辺厚、倉智嘉久
  • Organizer: 第86回日本薬理学会年会
  • Place of Presentation: 福岡国際会議場（福岡県）
• [Presentation] アストロサイトのカリウム緩衝機能のモデル解析 (2013)
  • Author(s): 村上慎吾、倉智嘉久
  • Organizer: 第86回日本薬理学会年会
  • Place of Presentation: 福岡国際会議場（福岡県）
• [Presentation] 心筋Naチャネル遮断による催不整脈リスクは虚血境界領域のNaチャネルリモデリングで説明できる. (2013)
  • Author(s): 津元国親、芦原貴司、原口亮、中沢一雄、倉智嘉久
  • Organizer: 第90回日本生理学会大会
  • Place of Presentation: タワーホール船堀（東京都）
• [Presentation] アセチルコリン感受性カリウム電流の短期脱感作のシミュレーション解析 (2013)
  • Author(s): 村上慎吾、稲野辺厚、倉智嘉久
  • Organizer: 第90回日本生理学会大会
  • Place of Presentation: タワーホール船堀（東京都）
• [Presentation] 第III群坑不整脈薬によるhERGチャネル阻害とファシリテーション作用の心筋活動電位への影響：シミュレーション研究 (2013)
  • Author(s): 古谷和春、津元国親、陳以珊、倉智嘉久
  • Organizer: 第90回日本生理学会大会
  • Place of Presentation: タワーホール船堀（東京都）
• [Presentation] システムズバイオロジーのための京コンピュータへの期待 (2013)
  • Author(s): 北野宏明
  • Organizer: 第4回スーパーコンピュータ「京」と創薬・医療の産学連携セミナー -HPCI計算生命科学推進プログラム-
  • Place of Presentation: フクラシア東京ステーション
  • Invited
• [Presentation] Systems Drug Design and Software Platform for drug efficacy and adverse effects prediction (2013)
  • Author(s): Hiroaki Kitano
  • Organizer: FDA Workshop: Systems Pharmacology for the Prediction of Tyrosine Kinase Inhibitor non-QT Cardiotoxicity
  • Place of Presentation: FDA White Oak Campus (USA)
  • Invited
• [Presentation] PIP2 dynamics undelying muscarinic or vasopression receptor-activated TRPC3, C6 and C7 currents (2013)
  • Author(s): Kyohei Itsuki, Yuko Imai, Yasushi Okamura, Ryuji Inoue, and Masayuki X. Mori
  • Organizer: 57th Annual Meeting of Biophysical Society
  • Place of Presentation: Philadelphia, Pennsylvania (USA)
• [Presentation] Pathophysiological mechanism involved in mechanotransduction at podocyte TRPC6 channel signaling complex (2013)
  • Author(s): Ryuji Inoue, Jun Ichikawa, Midori Nakagawa
  • Organizer: Symposium 6 “New therapeutic insights for chronic kidney disease provided by the podocytology. The 86th Annual Meeting of the Japanese Pharmacological Society. Symposium
  • Place of Presentation: 福岡国際会議場（福岡県）
• [Presentation] Druggability of TRP channels in cardiovascular disease (2013)
  • Author(s): Ryuji Inoue
  • Organizer: Collaboration Symposium with the Japanese Pharmacological Society. The 90th Annual meeting of the Physiological Society of Japan
  • Place of Presentation: タワーホール船堀（東京都）
• [Presentation] ホスホリパーゼC活性と連動した受容体作動型TRPCチャネルのキネティクス解析 (2013)
  • Author(s): 齊 郷平、今井裕子、安部喜八郎、井上隆司、森 誠之
  • Organizer: 第90回日本生理学会大会・シンポジウム
  • Place of Presentation: タワーホール船堀（東京都）
• [Presentation] 腸管狭窄線維化の進行における消化管筋線維芽細胞TRPC4, C6チャネルの役割 (2013)
  • Author(s): 倉原（海）琳、住吉美保、井上隆司
  • Organizer: 第90回日本生理学会大会
  • Place of Presentation: タワーホール船堀（東京都）
• [Presentation] 骨髄間質細胞周期制御における膜電位の役割 ―TRPC6チャネル関与の可能性― (2013)
  • Author(s): 市川 純、井上隆司
  • Organizer: 第90回日本生理学会大会
  • Place of Presentation: タワーホール船堀（東京都）
• [Presentation] cGMP依存性キナーゼのN末領域に存在する酸性アミノ酸はTRPC6との相互作用に必須である (2013)
  • Author(s): 本田 啓、井上隆司
  • Organizer: 第90回日本生理学会大会
  • Place of Presentation: タワーホール船堀（東京都）
• [Presentation] 消化管筋線維芽細胞TRPC6チャネルがTGF-b1/SMAD/MAPK/PI3K情報伝達に果たす役割 (2013)
  • Author(s): 住吉美保、倉原 琳、井上隆司
  • Organizer: 第90回日本生理学会大会
  • Place of Presentation: タワーホール船堀（東京都）
• [Presentation] A self-limiting regulation of TRPC3/C6/C7 channels linked with PIP2-PLC-DAG signaling (2012)
  • Author(s): Masayuki Mori, Yuko Imai, Kyohei Itsuki, Yasushi Okamiura, Ryuji Inoue
  • Organizer: 公募シンポジウム47,第89回日本生理学会大会
  • Place of Presentation: 長野県松本文化会館(長野県)
  • Year and Date: 2012-03-31
• [Presentation] Na^+チャネルの細胞内再分布による催不整脈性の変化 (2012)
  • Author(s): 津元国親、芦原貴司、原口亮、中沢一雄、倉智嘉久
  • Organizer: 第89回日本生理学会大会
  • Place of Presentation: 長野県松本文化会館(長野県)
  • Year and Date: 2012-03-30
• [Presentation] Arrhythmogenic potential of TRPM4 channel investigated in expression and an atrial myocytes line (2012)
  • Author(s): Ryuji Inoue, Yubin Duan, Hu Yaopeng
  • Organizer: 公募シンポジウム21,第89回日本生理学会大会
  • Place of Presentation: 長野県松本文化会館(長野県)
  • Year and Date: 2012-03-30
• [Presentation] 内向き整流性カリウムチャネルにおけるG蛋白質の結合とチャネル開閉の共役機構 (2012)
  • Author(s): 稲野辺厚、倉智嘉久
  • Organizer: 第89回日本生理学会大会
  • Place of Presentation: 長野県松本文化会館(長野県)
  • Year and Date: 2012-03-29
• [Presentation] スフィンゴ脂質による内向き整流性カリウムチャネル機能制御 (2012)
  • Author(s): 古谷和春、倉智嘉久
  • Organizer: 第89回日本生理学会大会
  • Place of Presentation: 長野県松本文化会館(長野県)
  • Year and Date: 2012-03-29
• [Presentation] 心筋Ca^<2+>シグナル制御の統合的システムバイオロジー (2012)
  • Author(s): 村上慎吾、倉智嘉久
  • Organizer: 第89回日本生理学会大会
  • Place of Presentation: 長野県松本文化会館(長野県)
  • Year and Date: 2012-03-29
• [Presentation] Phase-2 Reentry Associated with Subcellular Sodium Channel Remodeling : A Possible Mechanism of Fibrillation Induction in Brugada Syndrome (2012)
  • Author(s): Kunichika Tsumoto, Takashi Ashihara, Ryo Haraguchi, Kazuo Nakazawa, Yoshihisa Kurachi
  • Organizer: 第76回日本循環器学会学術集会
  • Place of Presentation: 福岡国際会議場(福岡県)
  • Year and Date: 2012-03-17
• [Presentation] Antiarrhythmic Agents Can Facilitate Voltage-Dependent Activation of hERG Potassium Channel (2012)
  • Author(s): Kazuharu Furutani, Kunichika Tsumoto, Yoshihisa Kurachi
  • Organizer: 第76回日本循環器学会学術集会
  • Place of Presentation: 福岡国際会議場(福岡県)
  • Year and Date: 2012-03-16
• [Presentation] アセチルコリン誘発性カリウム電流の短期脱感作の機序と生理的役割のモデル検討 (2012)
  • Author(s): 村上慎吾、倉智嘉久
  • Organizer: 第85回日本薬理学会年会
  • Place of Presentation: 国立京都国際会館(京都府)
  • Year and Date: 2012-03-15
• [Presentation] スフィンゴ脂質はKirチャネル機能を制御する (2012)
  • Author(s): 古谷和春、倉智嘉久
  • Organizer: 第85回日本薬理学会年会
  • Place of Presentation: 国立京都国際会館(京都府)
  • Year and Date: 2012-03-14
• [Presentation] アストロサイトモデルによるカリウムバッファリングの検討 (2012)
  • Author(s): 村上慎吾、倉智嘉久
  • Organizer: 第85回日本薬理学会年会
  • Place of Presentation: 国立京都国際会館(京都府)
  • Year and Date: 2012-03-14
• [Presentation] Garuda Overview/Garuda use case challenge : Yeast Signaling pathway curation (2012)
  • Author(s): Hiroaki Kitano
  • Organizer: Garuda Seven Workshop
  • Place of Presentation: 沖縄科学技術大学院大学・シーサイドハウス(沖縄県)
  • Year and Date: 2012-02-21
• [Presentation] Counteracting effect of TRPC1 mediated store-operated Ca^<2+> influx on TNFα-induced COX-2-dependent prostaglandin E_2 production in human colonic myofibroblasts (2012)
  • Author(s): Lin-Hai Kurahara, Yasuhiro Kawarabayashi, Akira Honda, Ryuji Inoue
  • Organizer: The 10^<th> Korea-Japan Joint Symposium
  • Place of Presentation: Daegyu, Korea
  • Year and Date: 2012-02-18
• [Presentation] 膜脂質とリン酸化によるTRPCチャネルを介したCa情報伝達制御機構 (2012)
  • Author(s): 井上隆司
  • Organizer: 蔵王カンファレンス
  • Place of Presentation: 山形
  • Year and Date: 2012-01-27
• [Presentation] Coupling of G protein binding to channel gating in inward rectifier K^+ channels (2012)
  • Author(s): Atsushi Inanobe, Yoshihisa Kurachi
  • Organizer: The 1st HD Physiology International Symposium : Integrative multi-level systems biology for in silico cardiology and pharmacokinetics
  • Place of Presentation: University of Tokyo Takeda hall (Tokyo)
  • Year and Date: 2012-01-21
• [Presentation] Modeling mechanism and physiological role of short term desensitization of cardiac K_<Ach> current (2012)
  • Author(s): Shingo Murakami, Yoshihisa Kurachi
  • Organizer: The 1st HD Physiology International Symposium : Integrative multi-level systems biology for in silico cardiology and pharmacokinetics
  • Place of Presentation: University of Tokyo Takeda hall (Tokyo)
  • Year and Date: 2012-01-21
• [Presentation] Simulation analysis on potassium buffering and water transport in astrocyte (2012)
  • Author(s): Shingo Murakami, Yoshihisa Kurachi
  • Organizer: The 1st HD Physiology International Symposium : Integrative multi-level systems biology for in silico cardiology and pharmacokinetics
  • Place of Presentation: University of Tokyo Takeda hall (Tokyo)
  • Year and Date: 2012-01-21
• [Presentation] A mechanism underlying compound-induced voltage shift in the current activation of hERG by antiarrhythmic agents (2012)
  • Author(s): Kazuharu Furutani, Yuko Yamakawa, Atsushi Inanobe, Kunichika Tsumoto, Yoshihisa Kurachi
  • Organizer: The 1st HD Physiology International Symposium : Integrative multi-level systems biology for in-silico cardiology and pharmacokinetics
  • Place of Presentation: University of Tokyo Takeda hall (Tokyo)
  • Year and Date: 2012-01-21
• [Presentation] The character of compounds facilitating hERG channel activation (2012)
  • Author(s): Yuko Yamakawa, Kazuharu Furutani, Atsushi Inanobe, Yoshihisa Kurachi
  • Organizer: The 1st HD Physiology International Symposium : Integrative multi-level systems biology for in silico cardiology and pharmacokinetics
  • Place of Presentation: University of Tokyo Takeda hall (Tokyo)
  • Year and Date: 2012-01-21
• [Presentation] Phase-2 Reentry Associated with Subcellular Sodium Channel Remodeling : A Possible Mechanism of Fibrillation Induction in Brugada Syndrome (2012)
  • Author(s): Kunichika Tsumoto, Takashi Ashihara, Ryo Haraguchi, Kazuo Nakazawa, Yoshihisa Kurachi
  • Organizer: The 1st HD Physiology International Symposium : Integrative multi-level systems biology for in silico cardiology and pharmacokinetics
  • Place of Presentation: University of Tokyo Takeda hall (Tokyo)
  • Year and Date: 2012-01-21
• [Presentation] Roles of subcellular sodium channel distribution in the mechanism of cardiac conduction (2012)
  • Author(s): Kunichika Tsumoto, Takashi Ashihara, Ryo Haraguchi, Kazuo Nakazawa, Yoshihisa Kurachi
  • Organizer: The 1st HD Physiology International Symposium : Integrative multi-level systems biology for in silico cardiology and pharmacokinetics
  • Place of Presentation: University of Tokyo Takeda hall (Tokyo)
  • Year and Date: 2012-01-21
• [Presentation] Possible contribution of TRPM4 channel to cardiac arrhythmogenicity evaluated in heterologously expressing cells and cultured atrial myocytes (2012)
  • Author(s): Yubin Duan, Yaopeng Hu, Ryuji Inoue
  • Organizer: The 1st HD Physiology International Symposium : Integrative Multi-level Systems Biology for In Silico Cardiology and Pharmacokinetics
  • Place of Presentation: University of Tokyo Takeda hall (Tokyo)
  • Year and Date: 2012-01-21
• [Presentation] HD-Physiology Project Overview (2012)
  • Author(s): Hiroaki Kitano
  • Organizer: The 1^<st> HD Physiology International Symposium
  • Place of Presentation: University of Tokyo Takeda hall (Tokyo)
  • Year and Date: 2012-01-20
• [Presentation] Multilevel modeling on PhysioDesigner (2012)
  • Author(s): Yoshiyuki Asai, Takeshi Abe, Tatsuhide Okamoto, Hideki Oka, Taishin Nomura, Yoshihisa Kurachi, Hiroaki Kitano
  • Organizer: 第51回日本生体医工学会大会
  • Place of Presentation: 福岡国際会議場（福岡県）
• [Presentation] 代数微分方程式で記述された心筋線維モデルにおける興奮伝導シミュレーション (2012)
  • Author(s): 津元国親, 淺井義之, 古谷和春, 倉智嘉久
  • Organizer: 第51回日本生体医工学会大会
  • Place of Presentation: 福岡国際会議場（福岡県）
• [Presentation] 心筋Na+チャネルの細胞内分布変化がI群抗不整脈薬の効果に影響を及ぼす可能性について (2012)
  • Author(s): 津元国親, 芦原貴司, 原口亮, 中沢一雄, 倉智嘉久
  • Organizer: 第121回日本薬理学会近畿部会
  • Place of Presentation: あわぎんホール（徳島県）
• [Presentation] In silico assessment of the clinical relevance of HERG channel modulations (2012)
  • Author(s): Kazuharu Furutani, Kunichika Tsumoto, Yoshihisa Kurachi
  • Organizer: The 13th international conference on system biology (ICSB 2012)
  • Place of Presentation: University of Toronto (Toronto, Canada)
• [Presentation] A platform for multilevel modeling of physiological systems: Template and instance framework for large scale models (2012)
  • Author(s): Yoshiyuki Asai, Takeshi Abe, Hideki Oka, Masao Okita, Hagihara Ken-ichi, Yukiko Matsuoka, Samik Ghosh, Yoshihisa Kurachi, Hiroaki Kitano
  • Organizer: 生体医工学シンポジウム2012
  • Place of Presentation: 大阪大学（大阪府）
• [Presentation] 心筋Naチャネルの細胞内局在によって発生するPhase-2リエントリー：ブルガダ症候群との関連において (2012)
  • Author(s): 津元国親、芦原貴司、原口亮、中沢一雄、倉智嘉久
  • Organizer: 第29回日本心電学会学術集会
  • Place of Presentation: 幕張メッセ国際会議場・ホテルニューオータニ幕張（千葉県）
• [Presentation] 薬物によるhERGチャネルのファシリテーション作用：分子機序とその意義 (2012)
  • Author(s): 古谷和春、津元国親、倉智嘉久
  • Organizer: 第29回日本心電学会学術集会
  • Place of Presentation: 幕張メッセ国際会議場・ホテルニューオータニ幕張（千葉県）
• [Presentation] Effects of block and facilitation of HERG channel by anti-arrhythmic agents on cardiac action potential: a simulation study (2012)
  • Author(s): 古谷和春、津元国親、倉智嘉久
  • Organizer: 第29回国際心臓研究学会(ISHR)日本部会総会
  • Place of Presentation: 九州大学医学部百年講堂（福岡県)
• [Presentation] 虚血心筋におけるNaチャネルの細胞内分布変化がI群抗不整脈薬の催不整脈性の機序に関与する可能性について (2012)
  • Author(s): 津元国親、芦原貴司、原口亮、中沢一雄、倉智嘉久
  • Organizer: 第28回心電情報処理ワークショップ
  • Place of Presentation: 熱海後楽園ホテル（静岡県）
• [Presentation] Multilevel Modeling and Simulation of Physiological Systems on PhysioDesigner (2012)
  • Author(s): Yoshiyuki Asai, Takeshi Abe, Hideki Oka, Yoshiyuki Kido, Li Li, Taishin Nomuran, Yoshihisa Kurachi, Hiroaki Kitano
  • Organizer: INCF Japan Node International Symposium ADVANCES IN NEUROINFORMATICS 2012
  • Place of Presentation: 理化学研究所（埼玉県）
• [Presentation] 抗不整脈薬のhERGチャネルファシリテーション作用：分子機序と不整脈治療における意義 (2012)
  • Author(s): 古谷和春、津元国親、陳以珊、山川祐子、倉智嘉久
  • Organizer: 第122回日本薬理学会近畿部会
  • Place of Presentation: 千里ライフサイエンスセンター（大阪府）
• [Presentation] Reconstitution of Cardiac G Protein-Gated Potassium Current：Effect of Muscarinic Agonists and RGS4 on Voltage-Dependent Response (2012)
  • Author(s): 陳以珊、古谷和春、稲野辺厚、倉智嘉久
  • Organizer: 第122回薬理学会近畿部会
  • Place of Presentation: 千里ライフサイエンスセンター（大阪府）
• [Presentation] 心筋虚血下におけるI群抗不整脈薬の催不整脈性の機序にNaチャネルの細胞内リモデリングが関与する可能性について (2012)
  • Author(s): 津元国親、芦原貴司、原口亮、中沢一雄、倉智嘉久
  • Organizer: 第122回日本薬理学会近畿部会
  • Place of Presentation: 千里ライフサイエンスセンター（大阪府）
• [Presentation] アセチルコリン感受性K+電流におけるshort term desensitization の機序のモデル検討 (2012)
  • Author(s): 村上慎吾、稲野辺厚、倉智 嘉久
  • Organizer: 第122回日本薬理学会近畿部会
  • Place of Presentation: 千里ライフサイエンスセンター（大阪府）
• [Presentation] 抗不整脈薬のhERGチャネルファシリテーション作用：分子機序と不整脈治療における意義 (2012)
  • Author(s): 古谷和春、津元国親、倉智嘉久
  • Organizer: 生理研研究会「心血管イオンチャネル・トランスポーター研究の新展開 -基礎研究と臨床研究の融合-」
  • Place of Presentation: 岡崎コンファランスセンター（愛知県)
  • Invited
• [Presentation] 陳旧性心筋梗塞下におけるI群抗不整脈薬の催不整脈作用の機序：心筋Naチャネルの 虚血誘発性細胞内リモデリングとの関連において (2012)
  • Author(s): 津元国親、芦原貴司、原口亮、中沢一雄、倉智嘉久
  • Organizer: 第22回日本循環薬理学会
  • Place of Presentation: 富山国際会議場（富山県）
• [Presentation] スフィンゴ脂質によるKirチャネル機能制御 (2012)
  • Author(s): 古谷和春、倉智嘉久
  • Organizer: 平成24年度筋生理の集い
  • Place of Presentation: 東京慈恵会医科大学高木会館（東京都）
  • Invited
• [Presentation] Will engineering play the lead role in drug discovery in 2030? (2012)
  • Author(s): Hiroaki Kitano
  • Organizer: BioMelbourne breakfast
  • Place of Presentation: Cinema 1 (Melbourne, Australia)
  • Invited
• [Presentation] Software Platform for Systems Drug Discovery (2012)
  • Author(s): Hiroaki Kitano
  • Organizer: Bio-IT World Asia Conference 2012
  • Place of Presentation: Marina Bay Sands (Singapore)
  • Invited
• [Presentation] Systems Drug Design and Garuda Software Platform. Network Biology SIG: On the Analysis and Visualization of Network in Biology (NetBio SIG) (2012)
  • Author(s): Hiroaki Kitano
  • Organizer: ISMB 2012
  • Place of Presentation: Long Beach Convention Center (CA, USA)
  • Invited
• [Presentation] HD-Physiology, Garuda, and Computational drug side-effects prediction (2012)
  • Author(s): Hiroaki Kitano
  • Organizer: Talk at FDA
  • Place of Presentation: FDA (Silver Spring, USA)
  • Invited
• [Presentation] Biological Robustness (2012)
  • Author(s): Hiroaki Kitano
  • Organizer: Seminar at University of Toronto
  • Place of Presentation: University of Toronto (Toronto, Canada)
  • Invited
• [Presentation] Systems Biology powered by Artificial Intelligence (2012)
  • Author(s): Hiroaki Kitano
  • Organizer: PRICAI-2012: 12th Pacific Rim International Conference on Artificial Intelligence
  • Place of Presentation: Pullman Hotel (Kuching, Malaysia)
  • Invited
• [Presentation] VPH in industrial research (2012)
  • Author(s): Hiroaki Kitano
  • Organizer: VPH 2012
  • Place of Presentation: Savoy Place (London, UK)
  • Invited
• [Presentation] システム創薬とGarudaプラットフォームの概要 (2012)
  • Author(s): 北野宏明
  • Organizer: BioJapan 2012
  • Place of Presentation: パシフィコ横浜（神奈川）
• [Presentation] Systems biomedicine and their computational platforms (2012)
  • Author(s): Hiroaki Kitano
  • Organizer: FOSBE 2012
  • Place of Presentation: Institute for Advanced Biosciences, Keio University（山形）
  • Invited
• [Presentation] システムバイオロジー概論 (2012)
  • Author(s): 北野宏明
  • Organizer: 第6回KASTシステムバイオロジー概論講座
  • Place of Presentation: かながわサイエンスパーク（神奈川）
  • Invited
• [Presentation] Systems Toxicology (2012)
  • Author(s): Hiroaki Kitano
  • Organizer: An invited talk at DSTO
  • Place of Presentation: Defence Science and Technology Organisation (DSTO), Department of Defence, Australian Government (Australia)
  • Invited
• [Presentation] Data-Driven Network-Based Biomarker Discovery (2012)
  • Author(s): 北野宏明
  • Organizer: 第35回 日本分子生物学会年会バイオテクノロジーセミナー
  • Place of Presentation: 福岡国際会議場（福岡）
  • Invited
• [Presentation] TRPM4チャネルの催不整脈性の再検討 (2012)
  • Author(s): Hu Yaopeng、Duan Yubin、市川純、倉原琳、井上隆司
  • Organizer: 生理研研究会「第8回TRPチャネル研究会」
  • Place of Presentation: 岡崎コンファレンスセンター（岡崎、愛知）
• [Presentation] ヒト子宮内膜間質細胞の脱落膜化過程におけるTRPC1の役割 (2012)
  • Author(s): 瓦林靖広、倉原（海）琳、本田啓、市川純、井上隆司
  • Organizer: 生理研研究会「第8回TRPチャネル研究会」
  • Place of Presentation: 岡崎コンファレンスセンター（岡崎、愛知）
• [Presentation] DrVSP、収縮作動薬によるPIP2 枯渇に対するTRPC3/C6/C7 チャネルの抑制的作用 (2012)
  • Author(s): 今井裕子、斎 郷平、岡村康司、森 誠之、井上隆司
  • Organizer: 第54回日本平滑筋学会総会
  • Place of Presentation: 東京慈恵会医科大学（東京）
• [Presentation] 炎症性腸疾患線維化狭窄における消化管筋線維芽細胞TRPC4,C6チャネルの役割 (2012)
  • Author(s): 倉原（海） 琳、住吉美保、井上隆司
  • Organizer: 第54回日本平滑筋学会総会シンポジウム
  • Place of Presentation: 東京慈恵会医科大学（東京）
• [Presentation] The role of TRPC1/C6 channels and STIM/Orai for cell cycle progression in bone marrow stromal cells (2012)
  • Author(s): Jun Ichikawa, Ryuji Inoue
  • Organizer: International Ion Channel Conference (IICC)
  • Place of Presentation: Jeju (Korea)
• [Presentation] TRPCとG蛋白質受容体刺激によるPIP2-DAG シグナルの連動性 (2012)
  • Author(s): 森 誠之、齊 郷平、井上隆司
  • Organizer: 生理研研究会「膜機能分子の機能・構造ゆらぎの時空間スペクトル解析」
  • Place of Presentation: 岡崎コンファレンスセンター（岡崎、愛知）
• [Presentation] 線維化促進因子TGF-β1下流における消化管筋線維芽細胞TRPC4,C6チャネルの役割 (2012)
  • Author(s): 倉原（海）琳、住吉美保、井上隆司
  • Organizer: 第63回西日本生理学会
  • Place of Presentation: 全労済ソレイユ（大分）
• [Presentation] DAG活性化型TRPCチャネルとPIP2動態のキネティクス解析 (2012)
  • Author(s): 齊 郷平、森 誠之、今井裕子、岡村康司、安部喜八郎、井上隆司
  • Organizer: 第63回西日本生理学会
  • Place of Presentation: 全労済ソレイユ（大分）
• [Presentation] TRPM4チャネル発現増加による不整脈誘発機構の検討 (2012)
  • Author(s): 胡 耀鵬、段 玉斌、倉原 琳、市川 純、井上隆司
  • Organizer: 第63回西日本生理学会
  • Place of Presentation: 全労済ソレイユ（大分）
• [Presentation] Arrhythmogenic significance of TRPM4 channel evaluated by a new experimental approach (2012)
  • Author(s): Ryuji Inoue, Hu Yaopeng, Yubin Duan, Lin Hai. Jun Ichikawa
  • Organizer: International Conference of Physiological Sciences 2012. Symposium 3
  • Place of Presentation: Suzhou (China)
• [Presentation] TRPC6チャネルを巡る機械刺激受容伝達異常と家族性腎糸球体硬化症 (2012)
  • Author(s): 井上隆司、市川純、中川緑
  • Organizer: 生理研研究会「イオンチャネル・トランスポーターと心血管機能：細胞機能の分子機序とその統合的理解」
  • Place of Presentation: 岡崎コンファレンスセンター（岡崎、愛知）
• [Presentation] TRPC6チャネルを制御するI型cGMP依存性キナーゼのTRPC6相互作用部位の解明 (2012)
  • Author(s): 本田 啓、井上隆司
  • Organizer: 第22回日本循環薬理学会
  • Place of Presentation: 富山国際会議場（富山県）
• [Presentation] 心血管病態におけるTRPチャネルの役割 (2011)
  • Author(s): 井上隆司
  • Organizer: 横浜市立大学医学部セミナー
  • Place of Presentation: 横浜
  • Year and Date: 2011-12-22
• [Presentation] 薬物のhERGチャネルと心筋活動電位に対する作用のシミュレーション研究 (2011)
  • Author(s): 古谷和春、津元国親、倉智嘉久
  • Organizer: 平成23年度筋生理の集い
  • Place of Presentation: 東京慈恵会医科大学高木会館(東京都)(招待講演)
  • Year and Date: 2011-12-17
• [Presentation] Systems Drag Design (2011)
  • Author(s): Hiroaki Kitano
  • Organizer: Lecture at Fudan University
  • Place of Presentation: Fudan University, Shanghai, (China)(招待講演)
  • Year and Date: 2011-12-16
• [Presentation] Systems Drug Design (2011)
  • Author(s): Hiroaki Kitano
  • Organizer: Lecture at Chinese Academy of Sciences
  • Place of Presentation: Chinese Academy of Sciences, Shanghai (China)(招待講演)
  • Year and Date: 2011-12-16
• [Presentation] hERGチャネル増強作用を持つ薬物の構造活性相関解析 (2011)
  • Author(s): 山川祐子、古谷和春、稲野辺厚、倉智嘉久
  • Organizer: 第21回日本循環薬理学会
  • Place of Presentation: 岡山大学50周年記念館(岡山県)
  • Year and Date: 2011-12-02
• [Presentation] TRPC3/C6/C7チャネルにおけるPIP2に対するサブタイプ特異的感受性と不活性化相関 (2011)
  • Author(s): 斎郷平、今井裕子、岡村康司、井上隆司、森誠之
  • Organizer: 生理研研究会「心血管イオンチャネル・トランスポーター研究の新展開」
  • Place of Presentation: 岡崎
  • Year and Date: 2011-11-30
• [Presentation] アセチルコリン感受性カリウム電流におけるshort term desensitizationの機序の検討 (2011)
  • Author(s): 村上慎吾、倉智嘉久
  • Organizer: 生理学研究所研究会「心血管イオンチャネル・トランスポーター研究の新展開--基礎研究と臨床研究の融合--」
  • Place of Presentation: 自然科学研究機構岡崎コンファレンスセンター(愛知県)(招待講演)
  • Year and Date: 2011-11-29
• [Presentation] Antiarrhythmic Agents Can Facilitate Voltage-Dependent Activation of hERG Potassium Channel (2011)
  • Author(s): Kazuharu Furutani, Yoshihisa Kurachi
  • Organizer: The 4th Global COE International Symposium on Physiome and Systems Biology for Integrated Life Sciences and Predictive Medicine
  • Place of Presentation: 千里ライフサイエンスセンター(大阪府)
  • Year and Date: 2011-11-21
• [Presentation] Predicting and identifying novel ER alpha agonists by pharmacophore-based virtual screening (2011)
  • Author(s): Daisuke Yamasaki, Kazuharu Furutani, Atsushi Inanobe, Yoshihisa Kurachi, Takefumi Doi
  • Organizer: The 4th Global COE International Symposium on Physiome and Systems Biology for Integrated Life Sciences and Predictive Medicine
  • Place of Presentation: 千里ライフサイエンスセンター(大阪府)
  • Year and Date: 2011-11-21
• [Presentation] Modeling from cell to multicellular system : Roles of subcellular sodium channel distribution in the mechanism of cardiac conduction (2011)
  • Author(s): Kunichika Tsumoto, Takashi Ashihara, Ryo Haraguchi, Kazuo Nakazawa, Yoshihisa Kurachi
  • Organizer: The 4th Global COE International Symposium on Physiome and Systems Biology for Integrated Life Sciences and Predictive Medicine
  • Place of Presentation: 千里ライフサイエンスセンター(大阪府)
  • Year and Date: 2011-11-21
• [Presentation] HD-Physiology Project and the Garuda Alliance Software and Resource Platform (2011)
  • Author(s): Hiroald Kitano
  • Organizer: The 4^<th> Global COE International Symposium on Physiome and Systems Biology for Integrated Life Sciences and Predictive Medicine
  • Place of Presentation: 千里阪急ホテル(大阪府)(招待講演)
  • Year and Date: 2011-11-21
• [Presentation] Correlation between Ca^<2+> influx channels expression and cell cycle stages in bone marrow stromal cells (2011)
  • Author(s): Jun Ichikawa, Ryuji Inoue
  • Organizer: BIT'S 4th Annual World Congress of Regenerative Medicine & Stem Cell-2011
  • Place of Presentation: Beijing, China
  • Year and Date: 2011-11-12
• [Presentation] スフィンゴ脂質によるカリウムチャネル機能制御 (2011)
  • Author(s): 古谷和春、倉智嘉久
  • Organizer: 第120回薬理学会近畿部会
  • Place of Presentation: ホテルグランビア京都(京都府)
  • Year and Date: 2011-11-11
• [Presentation] Mechanosensitive TRP channels in cardiovascular function and disease (2011)
  • Author(s): Ryuji Inoue, Yaopeng Hu, Yubin Duan, Yuko Imai, Kyohei Itsuki
  • Organizer: International Symposium on Mechanobiology (5th Shanghai International Conference on Biophysics and Molecular biology)
  • Place of Presentation: Shanghai, China
  • Year and Date: 2011-11-05
• [Presentation] Pharmacokinetic optimization of dosing regimen of aminosides and vancomycin in critically ill patients receiving continuous renal replacement therapy (2011)
  • Author(s): Takehito Yamamoto, Nobuhiro Yasuno, Akihiro Hisaka, Shoichi Katada, Norio Hanafusa, Eisei Noiri, Naoki Yahagi, Toshiro Fujita, Hiroshi Suzuki
  • Organizer: 12th International congress of Therapeutic Drug Monitoring & Clinical Toxicology
  • Place of Presentation: Stuttgart, Germany
  • Year and Date: 2011-10-04
• [Presentation] 心筋ナトリウムチャネルの細胞内分布変化が興奮伝導に及ぼす影響:in silico研究 (2011)
  • Author(s): 津元国親、芦原貴司、原口亮、中沢一雄、倉智嘉久
  • Organizer: 第104回近畿生理学談話会
  • Place of Presentation: 大阪医科大学(大阪府)
  • Year and Date: 2011-10-01
• [Presentation] スフィンゴ脂質によるカリウムチャネル機能制御 (2011)
  • Author(s): 古谷和春、倉智嘉久
  • Organizer: 生理学研究所研究会「超階層シグナル伝達研究の新展開」
  • Place of Presentation: 自然科学研究機構岡崎コンファレンスセンター(愛知県)(招待講演)
  • Year and Date: 2011-09-29
• [Presentation] Garuda Goals (2011)
  • Author(s): Hiroaki Kitano
  • Organizer: Garuda Six Workshop
  • Place of Presentation: Pavillon Skip (Luxembourg)
  • Year and Date: 2011-09-28
• [Presentation] 神経型G蛋白質制御内向き整流性K^+チャネルのサブユニット集合の多様性:細胞内局在の調節 (2011)
  • Author(s): 稲野辺厚、倉智嘉久
  • Organizer: 第84回日本生化学会大会
  • Place of Presentation: 国立京都国際会館(京都府)
  • Year and Date: 2011-09-23
• [Presentation] Effects of Subcellular Sodium Channel Distribution on the Initiation of Phase-2 Reentry : A Possible Mechanism of Fibrillation Induction in Brugada Syndrome (2011)
  • Author(s): Kunichika Tsumoto, Takashi Ashihara, Ryo Haraguchi, Kazuo Nakazawa, Yoshihisa Kurachi
  • Organizer: 26th Annual Scientific Session of the Japanese Heart Rhythm Society/28th Annual Scientific Session of the Japanese Society of Electrocardiology
  • Place of Presentation: Hilton Fukuoka Sea Hawk, Fukuoka (Japan)
  • Year and Date: 2011-09-22
• [Presentation] Inverse agonist-like action of cadmium on G-protein-gated inward-rectifier K^+ channels (2011)
  • Author(s): Atsushi Inanobe, Atsushi Nakagawa, Takanori Matsuura, Yoshihisa Kurachi
  • Organizer: The 7th Congress of the Federation of Asian and Oceanian Physiological Societies
  • Place of Presentation: NTUH International Convention Center, Taipei(台湾)
  • Year and Date: 2011-09-13
• [Presentation] Simulated potassium buffering and transport in an astrocyte model (2011)
  • Author(s): Shingo Murakami, Yoshihisa Kurachi
  • Organizer: The 7th Congress of the Federation of Asian and Oceanian Physiological Societies
  • Place of Presentation: NTUH International Convention Center, Taipei(台湾)
  • Year and Date: 2011-09-13
• [Presentation] In silico pharmacophore model of hERG channel facilitators (2011)
  • Author(s): Yuko Yamakawa, Kazuharu Furutani, Yoshihisa Kurachi
  • Organizer: The 7th Congress of the Federation of Asian and Oceanian Physiological Societies
  • Place of Presentation: NTUH International Convention Center, Taipei(台湾)
  • Year and Date: 2011-09-12
• [Presentation] Modeling short term desensitization in cardiac KACh current (2011)
  • Author(s): Shingo Murakami, Atsushi Inonobe, Yoshihisa Kurachi
  • Organizer: The 7th Congress of the Federation of Asian and Oceanian Physiological Societies
  • Place of Presentation: NTUH International Convention Center, Taipei(台湾)
  • Year and Date: 2011-09-12
• [Presentation] 薬物の消化管内移動を考慮した新しい生理学的吸収動態モデル (2011)
  • Author(s): 安藤裕崇, 樋坂章博, 鈴木洋史
  • Organizer: 第4回日本ファーマコメトリクス研究会
  • Place of Presentation: 東京
  • Year and Date: 2011-09-03
• [Presentation] How networks can be used to find diagnostic and therapeutic candidates (2011)
  • Author(s): Hiroaki Kitano
  • Organizer: International Conference on Systems Biology 2011 (ICSB2011)
  • Place of Presentation: University of Heidelberg, (Germany)(招待講演)
  • Year and Date: 2011-09-01
• [Presentation] Garuda Vision and Goals (2011)
  • Author(s): Hiroaki Kitano
  • Organizer: Garuda Five Workshop
  • Place of Presentation: University of Heidelberg (Germany)
  • Year and Date: 2011-09-01
• [Presentation] Act Beyond Borders (2011)
  • Author(s): Hiroaki Kitano
  • Organizer: International Conference on Systems Biology 2011 (ICSB2011)
  • Place of Presentation: Rosengarten Conference Center, Mannheim (Germany)(招待講演)
  • Year and Date: 2011-08-31
• [Presentation] iPathways-biological pathways on your palm! (2011)
  • Author(s): Samik Ghosh, Yukiko Matsuoka, Hiroald Kitano
  • Organizer: International Conference on Systems Biology 2011 (ICSB2011)
  • Place of Presentation: Rosengarten Conference Center, Mannheim (Germany)
  • Year and Date: 2011-08-30
• [Presentation] Integrated experimental and computational analysis for the dynamics of Tamoxifen resistance in MCF-7 cell lines (2011)
  • Author(s): Kang, H.; Samik Ghosh, Suzuki, K.; Yukiko Matsuoka, Hiroaki Kitano
  • Organizer: International Conference on Systems Biology 2011 (ICSB2011)
  • Place of Presentation: Rosengarten Conference Center, Mannheim (Germany)(招待講演)
  • Year and Date: 2011-08-29
• [Presentation] Niemann-Pick C2 stimulates the ABCG5/G8-mediated cholesterol secretion into bile (2011)
  • Author(s): Tappei Takada, Yoshihide Yamanashi, Hiroshi Suzuki
  • Organizer: 第43回日本動脈硬化学会総会・学術集会
  • Place of Presentation: 札幌
  • Year and Date: 2011-07-15
• [Presentation] アストロサイトモデルによるカリウムバッファリング・輸送の解析 (2011)
  • Author(s): 村上慎吾、倉智嘉久
  • Organizer: 第119回薬理学会近畿部会
  • Place of Presentation: ウィンク愛知(愛知県)
  • Year and Date: 2011-07-08
• [Presentation] Significance of intestinal metabolism for various substrate drugs of CYP3A4 (2011)
  • Author(s): Akihiro Hisaka, Ayako Tsukihashi, Hirotaka Ando, Hiroshi Suzuki
  • Organizer: International Symposium on BA/BE of Oral Drugs Products
  • Place of Presentation: Kobe, Japan
  • Year and Date: 2011-06-30
• [Presentation] Simulation of drug concentrations in enterocyte during absorption with a new pharmacokinetic model of gastrointestinal tracts ; translocation model (2011)
  • Author(s): Hirotaka Ando, Akihiro Hisaka, Ayako Tsukihashi, Hiroshi Suzuki
  • Organizer: International Symposium on BA/BE of Oral Drugs Products
  • Place of Presentation: Kobe, Japan
  • Year and Date: 2011-06-30
• [Presentation] システムバイオロジーの起源と展開(Origin and progress of systems biology) (2011)
  • Author(s): Hiroaki Kitano
  • Organizer: NC-BIO合同研究会
  • Place of Presentation: 琉球大学50周年記念館(沖縄県)(招待講演)
  • Year and Date: 2011-06-23
• [Presentation] A modeling/simulation platform for multi-level physiological functions (2011)
  • Author(s): Yoshiyuki Asai, Yoshiyuki Kido, Hideki Oka, Taishin Nomura, Hiroaki Kitano
  • Organizer: 新学術領域研究全体会議
  • Place of Presentation: 大阪大学中之島センター(大阪府)
  • Year and Date: 2011-06-20
• [Presentation] Towards an integrated platform for biophysical modeling (2011)
  • Author(s): Hiroaki Kitano, Yoshiyuki Asai, Kun-Yi Hsin, Sami Ghosh, Yukuko Matsuoka
  • Organizer: 新学術領域研究全体会議
  • Place of Presentation: 大阪大学中之島センター(大阪府)
  • Year and Date: 2011-06-20
• [Presentation] An Open Platform toward Large-scale Multilevel Modeling and Simulation of Physiological Systems (2011)
  • Author(s): Yoshiyuki Asai, Hideki Oka, Takeshi Abe, Masao Okita, Ken-ichi Hagihara, Taishin Nomura, Hiroaki Kitano
  • Organizer: The 11th IEEE/IPSJ International Symposium on Applications and the Internet (SAINT2011)
  • Place of Presentation: Munich (Germany)(招待講演)
  • Year and Date: 2011-06-19
• [Presentation] Towards a simulation platform for multi-level neuronal networks (2011)
  • Author(s): Yoshiyuki Asai, Hideki Oka, Taishin Nomura, Hiroaki Kitano
  • Organizer: The 3rd International Conference on Cognitive Neurodynamics (3rd ICCN)
  • Place of Presentation: Hilton Niseko Village, Hokkaido (Japan)
  • Year and Date: 2011-06-10
• [Presentation] Calculation of unambiguous intestinal availability from drug-drug interaction (2011)
  • Author(s): Akihiro Hisaka, Ayako Tsukihashi, Hiroshi Suzuki
  • Organizer: 4th Asia Pacific ISSX Regional Meeting
  • Place of Presentation: Tainan, Taiwan
  • Year and Date: 2011-04-23
• [Presentation] 心血管系における受容体・機械刺激活性化Ca^<2+>流入の分子病態生理学的意義 (2011)
  • Author(s): 井上隆司
  • Organizer: 第28回日本医学会総会5-S-6シンポジウム
  • Place of Presentation: 東京
  • Year and Date: 2011-04-09
• [Presentation] 膜脂質メッセンジャーを介した受容体・機械刺激Ca^<2+>応答の統合制御機構 (2011)
  • Author(s): 井上隆司、今井裕子、斎郷平、市川純、森誠之
  • Organizer: 第88回日本生理学会大会シンポジウム「脂質メディエーターの細胞機能と疾患」
  • Place of Presentation: パシフィコ横浜、横浜(招待講演)
  • Year and Date: 2011-03-29
• [Presentation] 定量的標的プロテオミクスによるファーマコプロテオミクスアプローチ (2011)
  • Author(s): 大槻純男
  • Organizer: 日本薬学会第131年会
  • Place of Presentation: ツインメッセ静岡、静岡(招待講演)
  • Year and Date: 2011-03-29
• [Presentation] Systems Drug Discovery and Platform Design. (2011)
  • Author(s): Hiroaki Kitano
  • Organizer: 15^<th> Human Genome Meeting : Genomics of Human Diversity and Heritable Disorders
  • Place of Presentation: Dubai International Convention & Exhibition Centre, Dubai, UAE(招待講演)
  • Year and Date: 2011-03-17
• [Presentation] Systems Medicine and Systems Drug Design as the Grand Challenge in 21st Century (2011)
  • Author(s): Hiroaki Kitano
  • Organizer: BioComplexity Symposium : Systems Biology Approach to Systems Drug Discovery and Systems Medicine
  • Place of Presentation: NUHS Tower Block, Singapore(招待講演)
  • Year and Date: 2011-02-14
• [Presentation] システムバイオロジーと創薬・医療応用 (2011)
  • Author(s): 北野宏明
  • Organizer: 「生命をはかる」研究会 第33回研究会
  • Place of Presentation: 東陽テクニカ(東京都)(招待講演)
  • Year and Date: 2011-02-07
• [Presentation] Systems Drug Design (2010)
  • Author(s): Hiroaki Kitano
  • Organizer: Systems Biology at the Interface of Metabolism and Signal Transduction
  • Place of Presentation: VU University Amsterdam, The Netherlands(招待講演)
  • Year and Date: 2010-12-17
• [Presentation] Quantitative semi-simultaneous imaging of Ca^<2+> and Ca^<2+>-dependent calmodulin interactions by FRET (2010)
  • Author(s): Masayuki Mori, Yuko Imai, Kyohei Isuki, Ryuji Inoue
  • Organizer: The 9^<th> Korea--Japan Joint Symposium of Brain Sciences, and Cardiac and Smooth Muscles
  • Place of Presentation: Keitenkaku, Kagoshima(招待講演)
  • Year and Date: 2010-11-26
• [Presentation] システム創薬-がんのシステム的理解と創薬への応用- (2010)
  • Author(s): 北野宏明
  • Organizer: 神奈川科学技術アカデミー(KAST)教育講座 システムバイオロジー講座
  • Place of Presentation: 神奈川科学技術アカデミー(KAST),神奈川(招待講演)
  • Year and Date: 2010-11-18
• [Presentation] PISCS (pharmacokinetic interaction significance classification system) : toward seamless drug-interaction alert (2010)
  • Author(s): Akihiro Hisaka
  • Organizer: Pharmaceutical sciences world congress (PSWC 2010)
  • Place of Presentation: Morial Convention Center, New Orleans, USA.
  • Year and Date: 2010-11-15
• [Presentation] Systems Robustness and Systems Failures in Biology, Medicine, and Engineering (2010)
  • Author(s): Hiroaki Kitano
  • Organizer: A^*STAR Scientific Conference 2010
  • Place of Presentation: A^*STAR, Singapore(招待講演)
  • Year and Date: 2010-11-10
• [Presentation] Systems Biology and Drug Discovery (2010)
  • Author(s): Hiroaki Kitano
  • Organizer: National University of Singapore, Biochemistry Seminar
  • Place of Presentation: National University of Singapore, Singapore(招待講演)
  • Year and Date: 2010-11-08
• [Presentation] 定量的標的プロテオミクスによって拓かれる新しい創薬研究への展開 (2010)
  • Author(s): 大槻純男
  • Organizer: 創剤フォーラム第16回シンポジウム
  • Place of Presentation: アルカディア市ヶ谷、東京(招待講演)
  • Year and Date: 2010-10-22
• [Presentation] An Open-flow Paradigm for Curation and Enrichment of Biological Pathways. (2010)
  • Author(s): Samik Ghosh, Yukiko Matsuoka, Hiroaki Kitano
  • Organizer: International Conference on Systems Biology (ICSB) 2010
  • Place of Presentation: Edinburgh International Conference Centre, UK
  • Year and Date: 2010-10-12
• [Presentation] PathText : Integrating Text Mining Resources with Biological Pathway Visualizations. (2010)
  • Author(s): Brian Kemper, Takuya Matsuzaki, Yukiko Matsuoka, Yoshimasa Tsuruoka, Hiroaki Kitano, Jun'ichi Tsujii, Sophia Ananiadou
  • Organizer: International Conference on Systems Biology (ICSB) 2010
  • Place of Presentation: Edinburgh International Conference Centre, UK
  • Year and Date: 2010-10-12
• [Presentation] Posttraslational regulation of Abcc2 through sumoylation (2010)
  • Author(s): Hiroshi Suzuki, Shuichi Sekine, Toshiharu Horie, Kousei Ito
  • Organizer: Falk Symposium 175 : XXI International Bile Acid Meeting
  • Place of Presentation: Freiburg, Germany
  • Year and Date: 2010-10-07
• [Presentation] Systems drug discovery and software platform for healthcare research and services. (2010)
  • Author(s): Hiroaki Kitano
  • Organizer: International Conference on Bioinformatics (InCoB)
  • Place of Presentation: Waseda University, Tokyo(招待講演)
  • Year and Date: 2010-09-27
• [Presentation] 多階層統合生体シミュレーションから生命機能の理解と予測医学の実現を目指して (2010)
  • Author(s): 北野宏明、井上隆司、鈴木洋史、倉智嘉久
  • Organizer: 新学術領域研究「多階層生体機能学」キックオフシンポジウム
  • Place of Presentation: 大阪大学中之島センター佐治敬三ホール、大阪(招待講演)
  • Year and Date: 2010-09-25
• [Presentation] 次世代のファーマコプロテオミクスと中枢神経作用薬の開発 (2010)
  • Author(s): 大槻純男
  • Organizer: 第20回日本臨床精神神経薬理学会・第40回日本神経精神薬理学会年会合同年会
  • Place of Presentation: 仙台国際センター、仙台(招待講演)
  • Year and Date: 2010-09-17
• [Presentation] Multiplexed-MRM法による膜タンパク質群の一斉定量とファーマコプロテオミクスへの応用 (2010)
  • Author(s): 大槻純男
  • Organizer: 日本分析化学会第59年会
  • Place of Presentation: 東北大学川内キャンパス、仙台(招待講演)
  • Year and Date: 2010-09-16
• [Presentation] Nappによるモデリングとシミュレーションの紹介 (2010)
  • Author(s): 樋坂章博
  • Organizer: 第3回日本ファーマコメトリクス研究会
  • Place of Presentation: 昭和大学、東京
  • Year and Date: 2010-09-03
• [Presentation] タンパク質の定量によって拓かれる新しい創薬研究 (2010)
  • Author(s): 大槻純男
  • Organizer: 第23回バイオメディカル分析科学シンポジウム
  • Place of Presentation: ホテル大観荘、松島(招待講演)
  • Year and Date: 2010-07-23
• [Presentation] Hitting Robustness (2010)
  • Author(s): Hiroaki Kitano
  • Organizer: 16^<th> World Congress on Basic and Clinical Pharmacology (WorldPharma 2010)
  • Place of Presentation: Bella Center, Copenhagen, Denmark(招待講演)
  • Year and Date: 2010-07-19
• [Presentation] 心血管CaチャネルTRPC6の機能と制御-受容体機械刺激応答性のリン酸化を介した統合的制御機構- (2010)
  • Author(s): 井上隆司
  • Organizer: 第13回札幌高血圧セミナー
  • Place of Presentation: ホテルニューオータニ札幌、札幌(招待講演)
  • Year and Date: 2010-07-09
• [Presentation] Rationale of Garuda and introduction to Garuda-2 workshop (2010)
  • Author(s): Hiroaki Kitano
  • Organizer: Garuda Two Workshop
  • Place of Presentation: Manchester Interdisciplinary Biocentre, UK(招待講演)
  • Year and Date: 2010-07-05
• [Book] Weaving Knowledge into Biological Pathways in a Collaborative Manner in . Computational Systems Toxicology (eds. Julia Hoeng and Manuel C. Peitsch). (2015)
  • Author(s): Matsuoka Y, Fujita K, Ghosh S, Kitano H.
  • Total Pages: 28
  • Publisher: Humana Press, Springer
• [Book] Dr.北野のゼロから始めるシステムバイオロジー (2015)
  • Author(s): 北野宏明
  • Total Pages: 191
  • Publisher: 羊土社
• [Book] Modeling and Simulation Using CellDesigner. Transcription Factor Regulatory Networks. Methods in Molecular Biology (2014)
  • Author(s): Matsuoka, Y., A. Funahashi, S. Ghosh and H. Kitano
  • Publisher: Springer
• [Book] ギャノング生理学24版、分担翻訳（第V編 心血管の生理学概論 p593、29章 心臓の自動性と電気的活動 p594-614） (2014)
  • Author(s): 古谷和春、倉智嘉久
  • Total Pages: 896
  • Publisher: 丸善株式会社
• [Book] Mechanisms of action of antiarrhythmic drugs in ventricular Arrhythmias. In "Electrical Diseases of the Heart: Volume 1: Basic Foundations and Primary Electrical Diseases. 2nd edition" (2013)
  • Author(s): Murakami Shingo, Kurachi Yoshihisa
  • Total Pages: 632
  • Publisher: Springer-Verlag, London
• [Book] Software Platform for Metabolic Network Reconstruction of Mycobacterium tuberculosis. Systems Biology of Tuberculosis. (2013)
  • Author(s): Samik Ghosh, Yukiko Matsuoka, Yoshiyuki Asai, Hiroaki Kitano, Anshu Bhardwaj, Vinod Scaria, Rohit Vashisht, Anup Shah, Anupam Kumar Mondal, Priti Vishnoi, Kumari Sonal, Akanksha Jain, Priyanka Priyadarshini, Kausik Bhattacharyya, Vikas Kumar, Anurag Passi, Pratibha Sharma, Samir Brahmachari
  • Total Pages: 226
  • Publisher: Springer
• [Book] がんの多様性の数理. 実験医学2013年1月号 (2013)
  • Author(s): 北野宏明
  • Total Pages: 127
  • Publisher: 羊土社
• [Book] 不整脈学、分担執筆（第1章心筋の電気生理/3.パッチクランプの黎明といま、p8-11） (2012)
  • Author(s): 古谷和春、倉智嘉久
  • Total Pages: 614
  • Publisher: 南江堂
• [Book] 不整脈学、分担執筆（第16章不整脈学への道/1.パッチクランプでみえたもの、p588-591） (2012)
  • Author(s): 倉智嘉久、古谷和春
  • Total Pages: 614
  • Publisher: 南江堂
• [Book] Patch Clamp Techniques: From Beginning to Advanced Protocols (Springer Protocols Handbooks)、分担執筆（Chapter23、Heterologous Expression Systems and Analyses of Ion Channels、p353-370） (2012)
  • Author(s): Kazuharu Furutani, Yoshihisa Kurachi
  • Total Pages: 450
  • Publisher: Springer
• [Book] Cancer Systems Biology: A Robustness-Based Approach. HANDBOOK OF SYSTEMS BIOLOGY CONCEPTS AND INSIGHTS (2012)
  • Author(s): Hiroaki Kitano
  • Total Pages: 552
  • Publisher: Academic Press
• [Book] The pathophysiological implications of TRP channels in cardiac arrhythmia. In: "Cardiac Arrhythmias -New Considerations-" (2012)
  • Author(s): Ryuji Inoue, Yubin Duan, Yaopeng Hu, Jun Ichikawa
  • Total Pages: 544
  • Publisher: Open Access Publisher
• [Book] Lipid-mediated mechanisms involved in the mechanical activation of TRPC6 and TRPV4 channels in the vascular tone regulation. In: "Mechanosensitivity in Cells and Tissues" (2012)
  • Author(s): Ryuji Inoue, Yaopeng Hu, Yubin Duan and Kyohei Itsuki
  • Total Pages: 429
  • Publisher: Springer
• [Book] NEW薬理学6版、分担執筆(3章、イオンチャネルとトランスポーター・カリウムイオン、p.65-68) (2011)
  • Author(s): 古谷和春、倉智嘉久
  • Total Pages: 4
  • Publisher: 南江堂
• [Book] 最新パッチクランプ実験技術法、分担執筆(21章、チャネル遺伝子発現システムとその解析法、p.210-221) (2011)
  • Author(s): 古谷和春、倉智嘉久
  • Total Pages: 12
  • Publisher: 吉岡書店
• [Book] 血管生物医学事典:日本血管生物医学会編(Cl^-チャネル,p.286-287.) (2011)
  • Author(s): 稲野辺厚、倉智嘉久
  • Total Pages: 2
  • Publisher: 朝倉書店
• [Book] 血管生物医学事典:日本血管生物医学会編(TRPチャネル,p.297-298.) (2011)
  • Author(s): 稲野辺厚、倉智嘉久
  • Total Pages: 2
  • Publisher: 朝倉書店
• [Book] Cell Physiology Sourcebook, 4^<th> Edition (Direct regulation of ion channels by G proteins. p.445-452.) (2011)
  • Author(s): Atsushi Inanobe, Yoshihisa Kurachi
  • Total Pages: 8
  • Publisher: Academic Press
• [Book] Cancer Robustness and Therapy Strategies(書籍タイトル:Cancer Systems Biology, Bioinformatics and Medicine, p.429-446) (2011)
  • Author(s): Hiroaki Kitano
  • Total Pages: 17
  • Publisher: Springer
• [Book] シスアム創薬とソフトウエア プラットフォーム.(書籍タイトル:遺伝子医学MOOK別冊「最新創薬インフォマティクス活用マニュアル」,p.62-66) (2011)
  • Author(s): 松岡由希子, 浅井義之, Samik Ghosh, 北野宏明
  • Total Pages: 5
  • Publisher: 株式会社メティカル ドゥ
• [Book] Software Platform for Metabolic Network Reconstruction of Mycobacterium tuberculosis.(書籍タイトル:Systems Biology of Tubarculosis,) (2011)
  • Author(s): Samik Ghosh, Yukiko Matsuoka, Yoshiyuki Asai, Hiroaki Kitano, Anshu Bhardwaj, Vinod Scaria, Rohit Vashisht, Anup Shah, Anupam Kumar Mondal, Priti Vishnoi, Kumari Sonal, Akanksha Jain, Priyanka Priyadarshini, Kausik Bhattacharyya, Vikas Kumar, Anurag Passi, Pratibha Sharma, Open Source Drug Discovery Consortium, Samir Brahmachari
  • Publisher: Springer(In press)
• [Book] TRP channels and blood pressure regulation. In : TRP channel in health and disease : Implications for Diagnosis and Therapy(ed. : A.Szallasi) (2011)
  • Author(s): Ryuji Inoue, Juan Shi
  • Total Pages: 16
  • Publisher: Nova Science Publishers, UK
• [Book] The pathophysiological implications of TRP channels in cardiac arrhythmia. In : Cardiac Arrhythmias-New Considerations-, ISBN978-953-51-0126-0(ed.Francisco R.Breijo-Marquez) (2011)
  • Author(s): Ryuji Inoue, Yubin Duan, Yaopeng Hu, Jun Ichikawa
  • Total Pages: 24
  • Publisher: InTech Review-Open Access Publisher, http://www.intechopen.com
• [Book] Lipid-mediated mechanisms involved in the mechanical activation of TRPC6 and TRPV4 channels in the vascular tone regulation. In : "Mechanosensitivity in Cells and Tissues. Volume, No 6.-Mechanically Gated Channels and their regulation-"(eds.A.Kamkin & Kiseleva) (2011)
  • Author(s): Ryuji Inoue, Yaopeng Hu, Yubin Duan, Kyohei Itsuki
  • Publisher: Springer Verlag, Germany(in press)
• [Remarks] HD-Physiology Project
  • URL: http://hd-physiology.jp
• [Remarks] 新学術領域研究「多階層生体機能学」
  • URL: http://www.med.osaka-u.ac.jp/pub/pharma2/singaku/index.html
• [Remarks] PhysioDesigner
  • URL: http://www.physiodesigner.org
• [Remarks] Flint
  • URL: http://www.physiodesigner.org/simulation/flint/index.html
• [Remarks] HD-Physiology
  • URL: http://hd-physiology.jp/
• [Remarks] PhysioDesigner
  • URL: http://www.physiodesigner.org/
• [Remarks] HD-Physiology
  • URL: http://hd-physiology.jp/
• [Remarks] PhysioDesigner
  • URL: http://www.physiodesigner.org/
• [Remarks]
  • URL: http://hd-physiology.jp/
• [Remarks]
  • URL: http://www.med.osaka-u.ac.jp/pub/pharma2/
• [Remarks]
  • URL: http://physiodesigner.org/
• [Remarks]
  • URL: http://hd-physiology.jp/
• [Remarks]
  • URL: http://www.med.osaka-u.ac.jp/pub/pharma2/singaku/
• [Patent(Industrial Property Rights)] INTERACTION PREDICTION DEVICE, INTERACTION PREDICTION METHOD AND PROGRAM (2014)
  • Inventor(s): Hiroaki Kitano、他
  • Industrial Property Rights Holder: OIST, SBI
  • Industrial Property Rights Type: 特許
  • Filing Date: 2014-06-13
  • Overseas
• [Patent(Industrial Property Rights)] ソーシャルネットワークインターフェイスを使用した汎用シミュレーションシステム (2014)
  • Inventor(s): 浅井義之、他
  • Industrial Property Rights Holder: OIST, SBI
  • Industrial Property Rights Type: 特許
  • Industrial Property Number: 2014-560177
  • Filing Date: 2014-12-15
• [Patent(Industrial Property Rights)] ネットワークモデル統合装置、ネットワークモデル統合システム、 ネットワークモデル統合方法、および、プログラム (2013)
  • Inventor(s): 北野宏明, 松岡 由希子, Samik Ghosh
  • Industrial Property Rights Holder: OIST, SBI
  • Industrial Property Rights Type: 特許
  • Industrial Property Number: 2013-159876
  • Filing Date: 2013-07-31
  • Acquisition Date: 2014-10-31
• [Patent(Industrial Property Rights)] データ通信システム、データ解析装置、データ通信方法、および、プログラム (2013)
  • Inventor(s): 北野宏明, Samik Ghosh, 松岡由希子
  • Industrial Property Rights Holder: 北野宏明, Samik Ghosh, 松岡由希子
  • Industrial Property Rights Type: 特許
  • Filing Date: 2013-11-07
  • Overseas
• [Patent(Industrial Property Rights)] ネットワークモデル統合装置、ネットワークモデル統合システム、ネットワークモデル統合方法、および、プログラム (2013)
  • Inventor(s): 北野宏明, 松岡由希子, Samik Ghosh
  • Industrial Property Rights Holder: 北野宏明, 松岡由希子, Samik Ghosh
  • Industrial Property Rights Type: 特許
  • Industrial Property Number: 2013-159876
  • Filing Date: 2013-07-31
• [Patent(Industrial Property Rights)] General-Purpose Simulation System Using Social Network Interface (2013)
  • Inventor(s): 浅井義之、安部武志、北野宏明、他
  • Industrial Property Rights Holder: 浅井義之、安部武志、北野宏明、他
  • Industrial Property Rights Type: 特許
  • Filing Date: 2013-07-11
  • Overseas
• [Patent(Industrial Property Rights)] 相互作用予測装置、相互作用予測方法、および、プログラム (2013)
  • Inventor(s): 北野宏明, Kun-Yi Hsin, Samik Ghosh
  • Industrial Property Rights Holder: 北野宏明, Kun-Yi Hsin, Samik Ghosh
  • Industrial Property Rights Type: 特許
  • Filing Date: 2013-06-13
  • Overseas
• [Patent(Industrial Property Rights)] 相互作用予測装置、相互作用予測方法、および、プログラム (2012)
  • Inventor(s): 北野宏明, Kun- Yi Hsin, Samik Ghosh
  • Industrial Property Rights Holder: システム・バイオロジー研究機構, 沖縄科学技術大学院大学
  • Industrial Property Rights Type: 特許
  • Industrial Property Number: 2012-134261
  • Filing Date: 2012-06-13
• [Patent(Industrial Property Rights)] データ通信システム、データ解析装置、データ通信方法、および、プログラム (2012)
  • Inventor(s): 北野宏明, Samik Ghosh, 松岡由希子
  • Industrial Property Rights Holder: 沖縄科学技術大学院大学他
  • Industrial Property Rights Type: 特許
  • Industrial Property Number: 2012-245326
  • Filing Date: 2012-11-07
• [Patent(Industrial Property Rights)] General-Purpose Simulation System Using Social Network Interface (2012)
  • Inventor(s): Yoshiyuki Asai et al.
  • Industrial Property Rights Holder: OIST; SBI; Osaka University
  • Industrial Property Rights Type: 特許
  • Filing Date: 2012-07-12
  • Overseas
• [Patent(Industrial Property Rights)] ネットワークモデル統合装置、ネットワークモデル統合システム、ネットワークモデル統合方法、および、プログラム (2010)
  • Inventor(s): 北野宏明, 松岡由希子, Samik Ghosh
  • Industrial Property Rights Holder: 北野宏明, 松岡由希子, Samik Ghosh
  • Industrial Property Rights Type: 特許
  • Filing Date: 2010-10-01
  • Acquisition Date: 2013-08-09
• [Patent(Industrial Property Rights)] ネットワークモデル統合装置、ネットワークモデル統合システム、ネットワークモデル統合方法、および、プログラム (2010)
  • Inventor(s): 北野宏明、松岡由希子、サミックゴーシュ
  • Industrial Property Rights Holder: 独立行政法人沖縄科学技術研究基盤整備機構、特定非営利活動法人システム・バイオロジー研究機構
  • Industrial Property Number: 2010-224308
  • Filing Date: 2010-10-01