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Photon Pair Theranostics

Administrative Group

Project AreaCreation of diagnostic therapy using nuclear-multi-molecular interaction probes with entangled photon pairs
Project/Area Number 22H05021
Research Category

Grant-in-Aid for Transformative Research Areas (B)

Allocation TypeSingle-year Grants
Review Section Transformative Research Areas, Section (II)
Research InstitutionThe University of Tokyo

Principal Investigator

島添 健次  東京大学, 大学院工学系研究科(工学部), 准教授 (70589340)

Co-Investigator(Kenkyū-buntansha) 富田 英生  名古屋大学, 工学研究科, 准教授 (20432239)
佐藤 健  東京大学, 大学院工学系研究科(工学部), 准教授 (30507091)
重河 優大  国立研究開発法人理化学研究所, 仁科加速器科学研究センター, 特別研究員 (60845626)
Project Period (FY) 2022-05-20 – 2025-03-31
Project Status Granted (Fiscal Year 2024)
Budget Amount *help
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2024: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2023: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2022: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Keywords光子対診断治療学 / 角度相関 / 核医学 / 量子もつれ / ガンマ線 / 核スピン / アイソトープ / 腫瘍診断 / 治療学
Outline of Research at the Start

光子対診断治療学の実現のため、域内計画研究の進捗と連携を相互把握し、研究方針策定・改善を継続的に実施する。A01診るB01測るC01創るD01解る班の円滑な運営を行う。 A01/C01班:原子分子評価、C01/D01班:理論/実験計画、A01/B01班:個体・細胞連携、B01/C01 班:分光精製等重点課題の課題管理・連携を推進するとともに、成果の発信を実施する。

Outline of Annual Research Achievements

原子核→生体空間、化学反応→原子核エネルギーの空間エネルギー多階層構造をつなぐ新たな診断技術(量子もつれ光子放出原子核-分子間相互作用プローブ)の確立による革新的光子対診断治療学の創生の研究活動を総括、円滑に運営する。A班の可視化イメージング技術開発、B班の計測による物理的機構の解明、C班の薬剤開発、D班の理論による解明をつなぐために研究会の企画や国際ワークショップの企画、広報活動やデータのやり取りの整備など研究に必要な活動を実施した。円滑な研究活動を継続するために、情報交換、領域会議の場を設定する。加えて学会やアウトリーチ活動を昨年に引き続いて行った。最終的にこれまで得られてきた成果の取りまとめや今後の方向性を議論する場を設けた。また複数の招待講演を実施した。

Current Status of Research Progress
Current Status of Research Progress

2: Research has progressed on the whole more than it was originally planned.

Reason

A班の可視化イメージング技術開発、B班の計測による物理的機構の解明、C班の薬剤開発、D班の理論による解明をつなぐために研究会の企画や国際ワークショップの企画、広報活動やデータのやり取りの整備など研究に必要な活動を実施した。円滑な研究活動を継続するために、情報交換、領域会議の場を設定する。加えて学会やアウトリーチ活動を昨年に引き続いて行った。最終的にこれまで得られてきた成果の取りまとめや今後の方向性を議論する場を設けた。

Strategy for Future Research Activity

これまでの活動により、最終的なin vivoでの実験の準備が整ってきた。最終年度は海外からの関連する研究者は専門家を招聘し、得られてきた成果にたいして議論を行う。特にガンマ線の量子もつれに関する議論や核スピンを利用した診断治療学の可能性についてオープンに議論する場を設ける。またより詳細な実験、理論的研究を進めるために、各班の間を埋めるような研究者に声をかけ、本研究領域を拡大した大きな研究コミュニティを形成する。

Report

(2 results)
  • 2023 Annual Research Report
  • 2022 Annual Research Report
  • Research Products

    (40 results)

All 2024 2023 2022 Other

All Int'l Joint Research (2 results) Journal Article (22 results) (of which Int'l Joint Research: 5 results,  Peer Reviewed: 22 results,  Open Access: 18 results) Presentation (12 results) (of which Int'l Joint Research: 5 results,  Invited: 7 results) Book (2 results) Remarks (2 results)

  • [Int'l Joint Research] Johannes Gutenberg University Mainz(ドイツ)

    • Related Report
      2023 Annual Research Report
  • [Int'l Joint Research] Brookhaven National Laboratory(米国)

    • Related Report
      2023 Annual Research Report
  • [Journal Article] pH dependence of perturbed angular correlation in DOTA chelated $$^{111}$$In measured with ring-shape gamma-ray detectors2024

    • Author(s)
      Shimazoe Kenji、Donghwan Kim、Mineo Tomoko、Sato Takeshi、Ohta Seiichi、Tatsumi Toshifumi、Sugiyama Akira、Yamatsugu Kenzo、Nomura Sachiyo、Terabayashi Ryohei、Tomita Hideki、Sonoda Tetsu、Shigekawa Yudai、Yokokita Takuya、Uenomachi Mizuki
    • Journal Title

      Interactions

      Volume: 245 Issue: 1 Pages: 22-22

    • DOI

      10.1007/s10751-024-01864-7

    • Related Report
      2023 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Modality for estimating NMR relaxation time using perturbed angular correlation in double-photon emission nuclides2024

    • Author(s)
      Matsumoto Wataru、Feng Boyu、Tamai Yoshiki、Ueki Taisei、Kamada Kei、Uenomachi Mizuki、Tomita Hideki、Fushimi Motofumi、Shimazoe Kenji、Takahashi Hiroyuki、Sekino Masaki
    • Journal Title

      AIP Advances

      Volume: 14 Issue: 1 Pages: 015217-015217

    • DOI

      10.1063/9.0000665

    • Related Report
      2023 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Implementation of the Time-Dependent Complete-Active-Space Self-Consistent-Field Method for Diatomic Molecules2024

    • Author(s)
      Li Yang、He Feng、Sato Takeshi、Ishikawa Kenichi L.
    • Journal Title

      The Journal of Physical Chemistry A

      Volume: 128 Issue: 8 Pages: 1523-1532

    • DOI

      10.1021/acs.jpca.3c06799

    • Related Report
      2023 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Time and Energy Resolving Time-over-Threshold ASIC for MPPC module in TOF-PET system (ToT-ASIC2)2023

    • Author(s)
      Orita T.、Uenomachi M.、Shimazoe K.、Ikeda H.
    • Journal Title

      Journal of Instrumentation

      Volume: 18 Issue: 09 Pages: P09033-P09033

    • DOI

      10.1088/1748-0221/18/09/p09033

    • Related Report
      2023 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Background reduction in PET by double Compton scattering of quantum entangled annihilation photons2023

    • Author(s)
      Kim Donghwan、Rachman Agus Nur、Taisei Ueki、Uenomachi Mizuki、Shimazoe Kenji、Takahashi Hiroyuki
    • Journal Title

      Journal of Instrumentation

      Volume: 18 Issue: 07 Pages: P07007-P07007

    • DOI

      10.1088/1748-0221/18/07/p07007

    • Related Report
      2023 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Improvement of double photon emission Compton imaging using angular and polarization correlations in cascade photons2023

    • Author(s)
      Kim Donghwan、Ueki Taisei、Rahman Agus Nur、Yan Linlin、Uenomachi Mizuki、Shimazoe Kenji、Takahashi Hiroyuki
    • Journal Title

      Journal of Instrumentation

      Volume: 18 Issue: 05 Pages: C05012-C05012

    • DOI

      10.1088/1748-0221/18/05/c05012

    • Related Report
      2023 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Simultaneous multi-nuclide imaging via reconstruction-free double-photon emission coincidence imaging method with parallel hole collimator and slat collimator2023

    • Author(s)
      Yan Linlin、Uenomachi Mizuki、Ueki Taisei、Kim Donghwan、Shimazoe Kenji、Takahashi Hiroyuki、Kamada Kei、Shigekawa Yudai、Nambu Akihiro、Yin Xiaojie、Wang Yang、Haba Hiromitsu
    • Journal Title

      Nuclear Instruments and Methods in Physics Research Section A: Accelerators, Spectrometers, Detectors and Associated Equipment

      Volume: 1053 Pages: 168305-168305

    • DOI

      10.1016/j.nima.2023.168305

    • Related Report
      2023 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Measurement of angular correlation changes in double-photon emission nuclides using ultrasound irradiation2023

    • Author(s)
      Sensui F.、Uenomachi M.、Shimazoe K.、Takahashi H.、Zhihong Z.、Ishijima A.、Nakagawa K.
    • Journal Title

      Journal of Instrumentation

      Volume: 18 Issue: 04 Pages: C04001-C04001

    • DOI

      10.1088/1748-0221/18/04/c04001

    • Related Report
      2023 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Aberrant Cadherin11 expression predicts distant metastasis of gastric cancer2023

    • Author(s)
      Mita Hideaki, Katoh Hiroto, Komura Daisuke, Kakiuchi Miwako, Abe Hiroyuki, Rokutan Hirofumi, Yagi Koichi, Nomura Sachiyo, Ushiku Tetsuo, Seto Yasuyuki, Ishikawa Shumpei.
    • Journal Title

      Pathology - Research and Practice

      Volume: 242 Pages: 154294-154294

    • DOI

      10.1016/j.prp.2022.154294

    • Related Report
      2023 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Multiancestry genomic and transcriptomic analysis of gastric cancer2023

    • Author(s)
      Totoki Y, Saito-Adachi M, Shiraishi Y, Komura D, Nakamura H, Suzuki A, Tatsuno K, Rokutan H, Hama N, Yamamoto S, Ono H, Arai Y, Hosoda F, Katoh H, et al.
    • Journal Title

      Nature Genetics

      Volume: 55 Issue: 4 Pages: 581-594

    • DOI

      10.1038/s41588-023-01333-x

    • Related Report
      2023 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Diagnostic utility of trefoil factor families for the early detection of lung cancer and their correlation with tissue expression2023

    • Author(s)
      Minegishi Kentaro, Dobashi Yoh, Koyama Teruhide, Ishibashi Yuko, Furuya Miki, Tsubochi Hiroyoshi, Ohmoto Yasukazu, Yasuda Tomohiko, Nomura Sachiyo.
    • Journal Title

      Oncology Letters

      Volume: 25 Issue: 4 Pages: 139-139

    • DOI

      10.3892/ol.2023.13725

    • Related Report
      2023 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Multivalent tyrosine kinase inhibition promotes T cell recruitment to immune-desert gastric cancers by restricting epithelial-mesenchymal transition via tumour-intrinsic IFN-γ signalling2023

    • Author(s)
      Cao L, Lu H, Nomura S. et al
    • Journal Title

      Gut

      Volume: 72(11) Issue: 11 Pages: 2038-50

    • DOI

      10.1136/gutjnl-2022-329134

    • Related Report
      2023 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Lymphatic flow mapping using near-infrared fluorescence imaging with indocyanine green helps to predict lymph node metastasis intraoperatively in patients with esophageal or esophagogastric junction cancer not treated with neoadjuvant chemotherapy2023

    • Author(s)
      Shiomi Shinichiro、Yagi Koichi、Iwata Ryohei、Yajima Shoh、Okumura Yasuhiro、Aikou Susumu、Yamashita Hiroharu、Nomura Sachiyo、Seto Yasuyuki
    • Journal Title

      Surgical Endoscopy

      Volume: 37 Issue: 11 Pages: 8214-8226

    • DOI

      10.1007/s00464-023-10368-4

    • Related Report
      2023 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Molecular and immune profiling of syngeneic mouse models predict response to immune checkpoint inhibitors in gastric cancer2023

    • Author(s)
      Lee D, Choi J, Nomura S. et al
    • Journal Title

      Cancer Res. Treat.

      Volume: 55(1) Issue: 1 Pages: 167-78

    • DOI

      10.4143/crt.2022.094

    • Related Report
      2023 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] YWHAG deficiency disrupts the EMT-associated network to induce oxidative cell death and prevent metastasis2023

    • Author(s)
      Lee XJT, Tan RW, Nomura S. et al
    • Journal Title

      Adv. Sci.

      Volume: 10 Issue: 31

    • DOI

      10.1002/advs.202301714

    • Related Report
      2023 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Platelets-cancer cells adhesion inhibition as a promising therapeutic target to prevent the peritoneal dissemination of gastric cancer2023

    • Author(s)
      Nakayama T, Saito R, Nomura S. et al
    • Journal Title

      Oncol. Lett.

      Volume: 26 Issue: 6 Pages: 538-538

    • DOI

      10.3892/ol.2023.14125

    • Related Report
      2023 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Efficient simulation of multielectron dynamics in molecules under intense laser pulses: implementation of the multiconfiguration time-dependent Hartree?Fock method based on the adaptive finite element method2023

    • Author(s)
      Orimo Yuki、Sato Takeshi、Ishikawa Kenichi L.
    • Journal Title

      Canadian Journal of Chemistry

      Volume: 101 Issue: 9 Pages: 664-671

    • DOI

      10.1139/cjc-2022-0280

    • Related Report
      2023 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Time-dependent multiconfiguration self-consistent-field and time-dependent optimized coupledcluster methods for intense laser-driven multielectron dynamics2023

    • Author(s)
      Takeshi Sato, Pathak Himadri, Yuki Orimo, Kenichi L. Ishikawa
    • Journal Title

      Canadian Journal of Chemistry

      Volume: Just-in Issue: 9 Pages: 1-22

    • DOI

      10.1139/cjc-2022-0297

    • Related Report
      2023 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Use of Erfgau Potential for Simulations of Multielectron Dynamics in Intense Laser Pulses2023

    • Author(s)
      Orimo Yuki、Sato Takeshi、Ishikawa Kenichi L.
    • Journal Title

      The Journal of Physical Chemistry A

      Volume: 127 Issue: 49 Pages: 10499-10505

    • DOI

      10.1021/acs.jpca.3c06530

    • Related Report
      2023 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Production and chemical separation of 229Pa toward observation of γ rays of 229mTh2023

    • Author(s)
      Shigekawa Yudai、Yin Xiaojie、Nambu Akihiro、Wang Yang、Haba Hiromitsu
    • Journal Title

      Journal of Radioanalytical and Nuclear Chemistry

      Volume: 333 Issue: 3 Pages: 1479-1486

    • DOI

      10.1007/s10967-023-09069-y

    • Related Report
      2023 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Multi-molecule imaging and inter-molecular imaging in nuclear medicine2022

    • Author(s)
      Shimazoe Kenji、Uenomachi Mizuki
    • Journal Title

      Bio-Algorithms and Med-Systems

      Volume: 18 Issue: 1 Pages: 127-134

    • DOI

      10.2478/bioal-2022-0081

    • Related Report
      2022 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] A double photon coincidence detection method for medical gamma-ray imaging2022

    • Author(s)
      Uenomachi Mizuki、Shimazoe Kenji、Takahashi Hiroyuki
    • Journal Title

      Bio-Algorithms and Med-Systems

      Volume: 18 Issue: 1 Pages: 120-126

    • DOI

      10.2478/bioal-2022-0080

    • Related Report
      2022 Annual Research Report
    • Peer Reviewed / Open Access
  • [Presentation] 量子もつれ光子対による原子核ー多分子間相互作用プロープを活用した診断治療学の創生2023

    • Author(s)
      島添 健次、上ノ町 水紀、富田 英生、寺林 稜平、園田 哲、向井 もも、重河 優大、杉山 暁、野村 幸世、横北 卓也、佐藤 健
    • Organizer
      日本科学振興協会 年次大会2023 「会いに行ける科学者フェス」
    • Related Report
      2023 Annual Research Report
  • [Presentation] Resonance Ionization Mass Spectroscopy on Americium2023

    • Author(s)
      H. Tomita, F. Weber, K. Wendt
    • Organizer
      Mazurian Lakes Conference on Physics 2023
    • Related Report
      2023 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 169Tm(d,2n)169Yb反応による169Ybの製造2023

    • Author(s)
      南部明弘, 重河優大, 殷小杰 臼田祥子, 羽場宏光
    • Organizer
      第60回アイソトープ・放射線研究発表会
    • Related Report
      2023 Annual Research Report
  • [Presentation] Antibody Mimetic Drug Conjugate によるがん治療法開発2023

    • Author(s)
      杉山 暁,巽 俊文,金井求,児玉龍彦,田中十志也,川村猛,徳山英利,坂田樹里,山次健三
    • Organizer
      第2回日本抗体学会
    • Related Report
      2023 Annual Research Report
  • [Presentation] RADIOIMMUNOTHERAPY OF AT-211-LABELED ANTI-FIBROBLAST GROWTH FACTOR RECEPTOR 4 (FGFR4) ANTIBODY IS A PROMISING TREATMENT FOR PERITONEAL DISSEMINATION OF GASTRIC CANCER: IN IMMUNOCOMPETENT MICE STUDY2023

    • Author(s)
      Komei Kuge, Hiroki Masuda, Wan-Ying Du, Tomohiko Yasuda, Akira Sugiyama, Hiromitsu Haba, Toshifumi Tatsumi, Nobuyoshi Akimitsu, Yoshitaka Kumakura, Hiroshi Yoshida, Yasuyuki Seto, Youichiro Wada, Sachiyo Nomura
    • Organizer
      DDW2023
    • Related Report
      2023 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Simulations of intense laser-driven nonadiabatic molecular dynamics using classical and quantum computers2023

    • Author(s)
      Takeshi Sato
    • Organizer
      International Symposium on Ultrafast Intense Laser Science (ISUILS2023),
    • Related Report
      2023 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Molecular Sensing and Imaging through Perturbed Angular Correlation in Nuclear Medicine2023

    • Author(s)
      Kenji Shimazoe
    • Organizer
      HYPERFINE INTERACTION
    • Related Report
      2023 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] 放射線を視る。放射線で診る。2023

    • Author(s)
      島添健次
    • Organizer
      第3回SITワークショップ
    • Related Report
      2023 Annual Research Report
    • Invited
  • [Presentation] PET検出器におけるデータ取得及び信号処理2023

    • Author(s)
      島添健次
    • Organizer
      日本核医学会PET核医学分科会 PETサマーセミナー2023
    • Related Report
      2023 Annual Research Report
    • Invited
  • [Presentation] 光子対を用いた核医学量子イメージングの展開2023

    • Author(s)
      島添健次
    • Organizer
      量子生命科学会第5回大会光量子センシングセッション
    • Related Report
      2023 Annual Research Report
    • Invited
  • [Presentation] 量子もつれ光子対に基づく医用多分子間相互作用イメージングの研究2023

    • Author(s)
      島添 健次
    • Organizer
      第70回応用物理学会春季学術講演
    • Related Report
      2022 Annual Research Report
    • Invited
  • [Presentation] Multi-isotope imaging and quantum chemical sensing with PET and SPECT nuclides2022

    • Author(s)
      Kenji Shimazoe
    • Organizer
      4th Jagiellonian Symposium on Advances in Particle Physics and Medicine
    • Related Report
      2022 Annual Research Report
    • Int'l Joint Research / Invited
  • [Book] 量子生命科学ハンドブック 第5章 医療分野における量子技術2024

    • Author(s)
      島添健次、上ノ町水紀
    • Total Pages
      372
    • Publisher
      (株)エヌ・ティー・エス
    • ISBN
      9784860438821
    • Related Report
      2023 Annual Research Report
  • [Book] 量子生命科学ハンドブック 光量子による放射性核種分析法の開発2024

    • Author(s)
      富田 英生, 寺林稜平
    • Total Pages
      372
    • Publisher
      NTS
    • ISBN
      9784860438821
    • Related Report
      2023 Annual Research Report
  • [Remarks] 光子対診断治療学ホームページ

    • Related Report
      2023 Annual Research Report
  • [Remarks] 光子対診断治療学ホームページ

    • URL

      https://photondiagnostic.org/

    • Related Report
      2022 Annual Research Report

URL: 

Published: 2022-05-25   Modified: 2024-12-25  

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