Brain Environment

• Project Area: Brain Environment
• Project/Area Number: 23111001
• Research Category: Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)
• Allocation Type: Single-year Grants
• Review Section: Biological Sciences
• Research Institution: Kyoto University
• Principal Investigator: Takahashi Ryosuke 京都大学, 医学(系)研究科(研究院), 教授 (90216771)
• Co-Investigator(Kenkyū-buntansha): 山中 宏二 独立行政法人理化学研究所, その他部局等, 研究員 (80446533)
• Co-Investigator(Renkei-kenkyūsha): Kiyama Hiroshi 名古屋大学, 医学系研究科, 教授 (00192021) ; Yamanaka Koji 名古屋大学, 環境医学研究所, 教授 (80446533) ; Higuchi Makoto 放射線医学総合研究所, チームリーダー (10373359) ; Uchiyama Yasuo 順天堂大学, 医学部, 教授 (10049091) ; Hattori Nobutaka 順天堂大学, 医学部, 教授 (80218510) ; Takumi Toru 理化学研究所BSI, シニアチームリーダー (00222092) ; Kawakami Hideshi 広島大学, 原爆放射線医科学研究所, 教授 (70253060) ; Urushitani Makoto 京都大学, 大学院医学研究科, 准教授 (60332326)
• Project Period (FY): 2011-04-01 – 2016-03-31
• Project Status: Completed (Fiscal Year 2015)
• Budget Amount: ¥40,040,000 (Direct Cost: ¥30,800,000、Indirect Cost: ¥9,240,000); Fiscal Year 2015: ¥9,230,000 (Direct Cost: ¥7,100,000、Indirect Cost: ¥2,130,000); Fiscal Year 2014: ¥6,370,000 (Direct Cost: ¥4,900,000、Indirect Cost: ¥1,470,000); Fiscal Year 2013: ¥7,800,000 (Direct Cost: ¥6,000,000、Indirect Cost: ¥1,800,000); Fiscal Year 2012: ¥6,760,000 (Direct Cost: ¥5,200,000、Indirect Cost: ¥1,560,000); Fiscal Year 2011: ¥9,880,000 (Direct Cost: ¥7,600,000、Indirect Cost: ¥2,280,000)
• Keywords: 脳神経疾患 / 神経科学 / 遺伝子 / 改造学 / 蛋白質 / 解剖学

Outline of Final Research Achievements

Project managing group members had served for management and planning of project meetings, international symposiums and research supports. The research meetings were held twice a year, and evaluated the progress of each project, collaborations, and the resource sharing. We organized the annual research workshop, and the international symposium with the distinguished oversea invitees from oversea, four times. We supported young investigators by research grant to generate transgenic mice and monoclonal antibodies. Two PhD students were awarded for the travel grant to attend the annual meeting of Society for Neuroscience in U.S. Many outreach activities for non-expert audience or high school students were performed to present our research activity. We supported the selected young investigators by a research grant required for their projects. Our achievements were open for discussion in the internet forum, and was summarized as pathway map, designated as “Brain Environment Map”.

Research Products

• [Journal Article] CUL2-mediated clearance of misfolded TDP-43 is paradoxically affected by VHL in oligodendrocytes in ALS. (2016)
  • Author(s): Uchida T, Tamaki Y, Ayaki T, Shodai A, Kaji S, Morimura T, Banno Y, Nishitsuji K, Sakashita N, Maki T, Yamashita H, Ito H, Takahashi R, Urushitani M.
  • Journal Title: Scientific Reports Volume: 6 Issue: 1 Pages: 19118-19136
  • DOI: 10.1038/srep19118
  • NAID: 120005689210
  • Peer Reviewed / Open Access
• [Journal Article] Viable neuronopathic Gaucher disease model in medaka (Oryzias latipes) displays axonal accumulation of alpha-synuclein (2015)
  • Author(s): Norihito Uemura, Masato Koike, Satoshi Ansai, Masato Kinoshita, Tomoko Ishikawa-Fujiwara, Hideaki Matsui, Kiyoshi Naruse, Naoaki Sakamoto, Yasuo Uchiyama, Takeshi Todo, Shunichi Takeda, Hodaka Yamakado, Ryosuke Takahashi
  • Journal Title: PLoS Genetics Volume: 11 Issue: 4 Pages: 1-14
  • DOI: 10.1371/journal.pgen.1005065
  • Peer Reviewed / Open Access
• [Journal Article] Astrocyte-Derived TGF-β1 Accelerates Disease Progression in ALS Mice by Interfering with the Neuroprotective Functions of Microglia and T Cells. (2015)
  • Author(s): Endo F, Komine O, Fujimori-Tonou N, Katsuno M, Jin S, Watanabe S, Sobue G, Dezawa M, Wyss-Coray T, Yamanaka K
  • Journal Title: Cell Reports Volume: 11 Issue: 4 Pages: 592-604
  • DOI: 10.1016/j.celrep.2015.03.053
  • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
• [Journal Article] CHCHD2 mutations in autosomal dominant late-onset Parkinson’s disease: a genome-wide linkage and sequencing study. (2015)
  • Author(s): Funayama M, Ohe K, Amo T, Furuya N, Yamaguchi J, Saiki S, Yuanzhe L, Ogaki K, Ando M, Yoshinon H, Tomiyama H, Nishioka K, Hasegawa K, Saiki H, Satake W, Mogushi K, Sasaki R, Kokubo Y, Kuzuhara S, Toda T, Mizuno Y, Uchiyama Y, Ohno K, Hattori N.
  • Journal Title: Lancet Neurol Volume: 14 Issue: 3 Pages: 274-282
  • DOI: 10.1016/s1474-4422(14)70266-2
  • Peer Reviewed / Open Access
• [Journal Article] Ｎｅｕｒｏｎａｌ ｅｘｏｓｏｍｅｓ ｆａｃｉｌｉｔａｔｅ ｓｙｎａｐｔｉｃ ｐｒｕｎｉｎｇ ｂｙ ｕｐ－ｒｅｇｕｌａｔｉｎｇ ｃｏｍｐｌｅｍｅｎｔ ｆａｃｔｏｒｓ ｉｎ ｍｉｃｒｏｇｌｉａ． (2015)
  • Author(s): Ｂａｈｒｉｎｉ， Ｉ．， Ｓｏｎｇ， Ｊ．， Ｄｉｅｚ， Ｄ．， Ｈａｎａｙａｍａ， Ｒ．
  • Journal Title: Ｓｃｉｅｎｔｉｆｉｃ Ｒｅｐｏｒｔｓ Volume: ５ Issue: 1 Pages: 1-8
  • DOI: 10.1038/srep07989
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] パーキンソン病治療ガイドラインの現状と今後の展望 (2015)
  • Author(s): 高橋良輔
  • Journal Title: Frontiers in Parkinson Diease Volume: 8 Pages: 5-11
• [Journal Article] iPS細胞を用いた神経変性疾患モデル (2015)
  • Author(s): 後藤和也、高橋良輔、井上治久
  • Journal Title: 実験医学 Volume: 33 Pages: 282-285
• [Journal Article] Idiopathic Normal Pressure Hydrocephalus has a Different Cerebrospinal Fluid Biomarker Profile from Alzheimer's Disease (2014)
  • Author(s): Naoto Jingami, Megumi Asada-Utsugi, Kengo Uemura, Rio Noto, Makio Takahashi, Akihiko Ozaki, Takeshi Kihara, Takashi Kageyama, Ryosuke Takahashi, Shun Shimohama, Ayae Kinoshita.
  • Journal Title: Jounral of Alzheimer's Disease Volume: 126（４） Issue: 1 Pages: 675-81
  • DOI: 10.3233/jad-142622
  • NAID: 120005593597
  • Peer Reviewed / Open Access
• [Journal Article] Exploring the Pathogenetic Mechanisms underlying Parkinson's Disease in Medaka Fish. (2014)
  • Author(s): Matsui H, Uemura N, Yamakado H, Takeda S, Takahashi R
  • Journal Title: J Parkinsons Dis Volume: 4 Issue: 2 Pages: 301-310
  • DOI: 10.3233/jpd-130289
  • Peer Reviewed / Open Access
• [Journal Article] Transglutaminase 2 accelerates neuroinflammation in amyotrophic lateral sclerosis through interaction with misfolded superoxide dismutase 1. (2014)
  • Author(s): Oono M, Okado-Matsumoto A, Shodai A, Ido A, Ohta Y, Abe K, Ayaki T, Ito H, Takahashi R, Taniguchi N, Urushitani M.
  • Journal Title: J Neurochem Volume: 128（3） Issue: 3 Pages: 403-418
  • DOI: 10.1111/jnc.12441
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Attenuation of endoplasmic reticulum stress in Pelizaeus-Merzbacher disease by an anti-malaria drug, chloroquine. (2014)
  • Author(s): Morimura T, Numata Y, Nakamura S, Hirano E, Gotoh L, Goto YI, Urushitani M, Inoue K.
  • Journal Title: Exp Biol Med Volume: 239 Issue: 4 Pages: 489-501
  • DOI: 10.1177/1535370213520108
  • Peer Reviewed
• [Journal Article] Protein Disulfide Isomerase P5-Immunopositive Inclusions in Patients with Alzheimer's Disease. (2014)
  • Author(s): Honjo Y, Horibe T, Torisawa A, Ito H, Nakanishi A, Mori H, Komiya T, Takahashi R, Kawakami K.
  • Journal Title: J Alzheimers Dis Volume: 38（3） Issue: 3 Pages: 601-609
  • DOI: 10.3233/jad-130632
  • Peer Reviewed
• [Journal Article] Involvement of Wnt/β-catenin signaling in the development of neuropathic pain. (2014)
  • Author(s): Itokazu T, Hayano Y, Takahashi R, Yamashita T.
  • Journal Title: Neurosci Res. Volume: 79 Pages: 34-40
  • DOI: 10.1016/j.neures.2013.12.002
  • Peer Reviewed / Open Access
• [Journal Article] XIAP immunoreactivity in glial and neuronal cytoplasmic inclusions in multiple system atrophy. (2014)
  • Author(s): Kawamoto Y, Ito H, Ihara M, Takahashi R.
  • Journal Title: Clin Neuropathol. Volume: 33(1) Issue: 01 Pages: 76-83
  • DOI: 10.5414/np300610
  • Peer Reviewed
• [Journal Article] Design, evaluation, and screening methods for efficient targeted mutage nesis with TALENs' in medaka. (2014)
  • Author(s): S. Ansai, K. Inohaya, Y. Yoshiu ra, M. Schartl, N. Uemura, R. Takahashi, M. Kinoshita
  • Journal Title: Development, Growth & Differentiation Volume: 56 Issue: 1 Pages: 98-107
  • DOI: 10.1111/dgd.12104
  • Peer Reviewed / Open Access
• [Journal Article] Exploring the Pathogenetic Mechanisms underlying Parkinson's Disease in Medaka Fish. (2013)
  • Author(s): Matsui H, Uemura N, Yamakado H, Takeda S, Takahashi R.
  • Journal Title: J Parkinsons Dis. Volume: 4(2) Pages: 301-310
  • Peer Reviewed
• [Journal Article] Chicken DT40 cell line lacking DJ-1, the gene responsible for familial Parkinson's disease, displays mitochondrial dysfunction. (2013)
  • Author(s): Minakawa EN, Yamakado H, Tanaka A, Uemura K, Takeda S, Takahashi R.
  • Journal Title: Neurosci Res. Volume: 77(4) Issue: 11 Pages: 228-233
  • DOI: 10.1016/j.clinph.2013.05.011
  • Peer Reviewed
• [Journal Article] The function of parkin: revisited. (2013)
  • Author(s): Yamakado H, Takahashi R.
  • Journal Title: Mov Disord. Volume: 28(14) Issue: 14 Pages: 1936-1936
  • DOI: 10.1002/mds.25711
  • Peer Reviewed
• [Journal Article] Genetic correction will be a standard method for the patient-derived ips cell research? (2013)
  • Author(s): Takahashi R, Yamakado H.
  • Journal Title: Mov Disord. Volume: 28(14) Issue: 14 Pages: 1935-1935
  • DOI: 10.1002/mds.25710
  • Peer Reviewed
• [Journal Article] Optineurin suppression causes neuronal cell death via NF-κB pathway. (2013)
  • Author(s): Akizuki M, Yamashita H, Uemura K, Maruyama H, Kawakami H, Ito H, Takahashi R.
  • Journal Title: J Neurochem Volume: 126(6) Issue: 6 Pages: 2230-41
  • DOI: 10.1111/jnc.12326
  • Peer Reviewed / Open Access
• [Journal Article] Continuation of exercise is necessary to inhibit high fat diet-inducde β-amyloid deposition and memory deficit in amyloid precursor protein transgenic mice. (2013)
  • Author(s): Masato Maesako, Kengo Uemura, Ayana Iwata, Masakazu Kubota, Kiwamu Watanabe, Maiko Uemura, Yasuha Noda, Megumi Asada-Utsugi, Takeshi Kihara, Ryosuke Takahashi, Shun Shimohama and Ayae Kinoshita.
  • Journal Title: PLos One Volume: 8 Issue: 9 Pages: e72796-e72796
  • DOI: 10.1371/journal.pone.0072796
  • Peer Reviewed / Open Access
• [Journal Article] Chronic overload of SEPT4, a parkin substrate that aggregates in Parkinson's disease, causes behavioral alterations but not neurodegeneration in mice (2013)
  • Author(s): Ageta-Ishihara N, Yamakado H, Morita T, Hattori S, Takao K, Miyakawa T, Takahashi R, Kinoshita M
  • Journal Title: Mol Brain Volume: 6 Issue: 1 Pages: 35-35
  • DOI: 10.1186/1756-6606-6-35
  • Peer Reviewed / Open Access
• [Journal Article] Copper enhances APP dimerization and promotes Abeta production (2013)
  • Author(s): Noda Y, Asada M, Kubota M, Maesako M, Watanabe K, Uemura M, Kihara T, Shimohama S, Takahashi R, Kinoshita A, Uemura K
  • Journal Title: Neuroscience Letters Volume: 547 Pages: 10-15
  • DOI: 10.1016/j.neulet.2013.04.057
  • Peer Reviewed / Open Access
• [Journal Article] PINK1 and Parkin complementarily protect dopaminergic neurons in vertebrates. (2013)
  • Author(s): Matsui H, Gavinio R, Asano T, Uemura N, Ito H, Taniguchi Y, Kobayashi Y, Maki T, Shen J, Takeda S, Uemura K, Yamakado H, Takahashi R.
  • Journal Title: Hum Mol Genet Volume: 22(12) Issue: 12 Pages: 2423-2434
  • DOI: 10.1093/hmg/ddt095
  • Peer Reviewed / Open Access
• [Journal Article] Response to comment on "Drug screening for ALS using patient-specific induced pluripotent stem cells". (2013)
  • Author(s): Egawa N, Kitaoka S, Tsukita K, Naitoh M, Takahashi K, Yamamoto T, Adachi F, Kondo T, Okita K, Asaka I, Aoi T, Watanabe A, Yamada Y, Morizane A, Takahashi J, Ayaki T, Ito H, Yoshikawa K, Yamawaki S, Suzuki S, Watanabe D, Hioki H, Kaneko T, Makioka K, Okamoto K, Takuma H, Tamaoka A, Hasegawa K, Nonaka T, Hasegawa
  • Journal Title: Sci Transl Med. Volume: 5(188) Issue: 188
  • DOI: 10.1126/scitranslmed.3005697
  • Peer Reviewed / Open Access
• [Journal Article] Loss of TDP-43 causes age-dependent progressive motor neuron degeneration (2013)
  • Author(s): Iguchi Y
  • Journal Title: Brain Volume: 136 Issue: 5 Pages: 1371-1382
  • DOI: 10.1093/brain/awt029
  • Peer Reviewed / Open Access
• [Journal Article] Aberrant assembly of RNA-recognition motif 1 links to pathogenic conversion of TAR DNA-binding protein-43 (TDP-43) (2013)
  • Author(s): Shodai A, Morimura T, Ido A, Uchida T, Ayaki T, Takahashi R, Kitazawa S, Suzuki S, Shirouzu M, Kigawa T, Muto Y, Yokoyama S, Takahashi R, Kitahara R, Ito H, Fujiwara N, Urushitani M
  • Journal Title: J Biol Chem Volume: 288(21) Issue: 21 Pages: 14886-14905
  • DOI: 10.1074/jbc.m113.451849
  • Peer Reviewed / Open Access
• [Journal Article] ATP13A2 deficiency induces a decrease in cathepsin D activity, fingerprint-like inclusion body formation, and selective degeneration of dopaminergic neurons. (2013)
  • Author(s): Matsui H, Sato F, Sato S, Koike M, Taruno Y, Saiki S, Funayama M, Ito H, Taniguchi Y, Uemura N, Toyoda A, Sakaki Y, Takeda S, Uchiyama Y, Hattori N, Takahashi R.
  • Journal Title: FEBS Lett Volume: 587(9) Issue: 9 Pages: 1316-1325
  • DOI: 10.1016/j.febslet.2013.02.046
  • Peer Reviewed / Open Access
• [Journal Article] A drug screening platform for Alzheimer's disease with intracellular Aβ oligomers using patient-specific iPSCs (2013)
  • Author(s): Kondo, T., (他24名), Murakami, K., Irie, K., Klein, W. L., Mori, H., Asada, T., Takahashi, R., Iwata, N., Yamanaka, S., Inoue, H
  • Journal Title: Cell Stem Cell Volume: 12 Issue: 4 Pages: 487-496
  • DOI: 10.1016/j.stem.2013.01.009
  • Peer Reviewed / Open Access
• [Journal Article] Visualization of Lenticulostriate Arteries by Flow-Sensitive Black-Blood MR Angiography on a 1.5T MRI System: A Comparative Study between Subjects with and without Stroke. AJNR Am J Neuroradiol. (2013)
  • Author(s): Okuchi S
  • Journal Title: AJNR Am J Neuroradiol Volume: 34 Issue: 4 Pages: 780-784
  • DOI: 10.3174/ajnr.a3310
  • Peer Reviewed
• [Journal Article] Gain of function by phosphorylation in Presenilin 1-mediated regulation of insulin signaling (2012)
  • Author(s): Maesako M, Uemura K, Kuzuya A, Sasaki K, Asada M, Watanabe K, Ando K, Kubota M, Akiyama H, Takahashi R, Kihara T, Shimohama S, Kinoshita A.
  • Journal Title: J Neurochem Volume: 121 Issue: 6 Pages: 964-973
  • DOI: 10.1111/j.1471-4159.2012.07741.x
  • Peer Reviewed
• [Journal Article] Parkin interacts with Klokin1 for mitochondrial import and maintenance of membrane potential. (2012)
  • Author(s): Kuroda Y
  • Journal Title: Hum Mol Genet Volume: 21(5) Pages: 991-1003
  • Peer Reviewed
• [Journal Article] A rat model for Lgi1-related epilepsies (2012)
  • Author(s): *Baulac S, Ishida S, *Mashimo T, Boillot M, Fumoto N, Kuwa mura M, Ohno Y, Takizawa A, Aoto T, Ueda M, Ikeda A, Leguern E, Takahashi R, Serikawa T
  • Journal Title: Hum Mol Genet Volume: 21(16) Issue: 16 Pages: 3546-57
  • DOI: 10.1093/hmg/dds184
  • NAID: 120005244992
  • Peer Reviewed
• [Journal Article] Exercise Is More Effective than Diet Control in Preventing High Fat Diet-induced β-Amyloid Deposition and Memory Deficit in Amyloid Precursor Protein Transgenic Mice. (2012)
  • Author(s): Maesako M
  • Journal Title: J Biol Chem. Volume: 287 Issue: 27 Pages: 23024-23033
  • DOI: 10.1074/jbc.m112.367011
  • Peer Reviewed
• [Journal Article] α-Synuclein BAC transgenic mice as a model for Parkinson's disease manifested decreased anxiety-like behavior and hyperlocomotion. (2012)
  • Author(s): Yamakado H
  • Journal Title: Neurosci Res Volume: 73(2) Issue: 2 Pages: 173-7
  • DOI: 10.1016/j.neures.2012.03.010
  • Peer Reviewed
• [Journal Article] Parkin pathway activation mitigates glioma cell proliferation and predicts patient survival. (2012)
  • Author(s): Yeo CW
  • Journal Title: Cancer Res Volume: 72 Issue: 10 Pages: 2543-2553
  • DOI: 10.1158/0008-5472.can-11-3060
  • Peer Reviewed
• [Journal Article] Donor-dependent variations in hepatic differentiation from human-induced pluripotent stem cells. (2012)
  • Author(s): Kajiwara M
  • Journal Title: Proc Natl Acad Sci U S A. Volume: 109 Issue: 31 Pages: 12538-12543
  • DOI: 10.1073/pnas.1209979109
  • Peer Reviewed
• [Journal Article] Drug screening for ALS using patient-specific induced pluripotent stem cells (2012)
  • Author(s): Egawa, N., Kitaoka, S., Tsukita, K., Naitoh, M., Takahashi, K., Yamamoto, T., Adachi, F., Kondo, T., Okita, K., Asaka, I., Aoi, T., Watanabe, A., Yamada, Y., Morizane, A., Takahashi, J., Ayaki, T., Ito, H., Yoshikawa, K., Yamawaki, S., Suzuki, S., Watanabe, D., Hioki, H., Kaneko, T., Makioka, K., Okamoto, K., Takuma, H., Tamaoka, A., Hasegawa, K., Nonaka, T., Hasegawa, M., Kawata, A., Yoshida, M., Nakahata, T., Takahashi, R., Marchetto, M. C. N., Gage, F. H., Yamanaka, S., and Inoue, H
  • Journal Title: Sci. Transl. Med. Volume: 4 Issue: 145 Pages: 1-8
  • DOI: 10.1126/scitranslmed.3004052
  • Peer Reviewed
• [Journal Article] "Hot cross bun" sign in multiple system atrophy with predominant cerebellar ataxia: A comparison between proton density-weighted imaging and T2-weighted imaging. (2012)
  • Author(s): Kasahara S, Miki Y, Kanagaki M, Kondo T, Yamamoto A, Morimoto E, Okada T, Ito H, Takahashi R, Togashi K
  • Journal Title: Eur J Radiol Volume: 81(10) Issue: 10 Pages: 2848-52
  • DOI: 10.1016/j.ejrad.2011.12.012
  • NAID: 120004873778
  • Peer Reviewed
• [Journal Article] In vivo imaging of brain ischemia using an oxygen-dependent degradative fusion prote in probe (2012)
  • Author(s): Fujita Y, Kuchimaru T、Kadonosono T, Tanaka S, Hase Y, Tomimoto H, Hiraoka M, Kizaka-Kondoh S, Ihara M, Takahashi R
  • Journal Title: PLoS ONE Volume: 7 Issue: 10 Pages: e48051-e48051
  • DOI: 10.1371/journal.pone.0048051
  • Peer Reviewed
• [Journal Article] Motor neuron-specific disruption of proteasomes, but not autophagy, replicates amyotrophic lateral sclerosis (2012)
  • Author(s): Y. Tashiro
  • Journal Title: Journal of Biological Chemistry Volume: 287 Issue: 51 Pages: 42984-42994
  • DOI: 10.1074/jbc.m112.417600
  • Peer Reviewed
• [Presentation] Takahashi R (2016)
  • Author(s): Takahashi R
  • Organizer: Keio Longevity Seminar Series “Resilience in Brain Agin –From Model Systems of Neurodegenerastion to Supercentenarian Study” Keio Longevity Initiative Seminar Series,
  • Place of Presentation: 東京
  • Year and Date: 2016-02-18
  • Invited
• [Presentation] Parkinson Disease Treatment: Current Perspective and Future Directions.(Plenary Lecture) (2015)
  • Author(s): Takahashi R
  • Organizer: ASEAN 2015 Neuroscience
  • Place of Presentation: Singapore
  • Year and Date: 2015-07-30
  • Invited
• [Presentation] TDP-43の病原構造の同定と抗体を用いた分子標的治療. (2015)
  • Author(s): 漆谷 真
  • Organizer: 第56回 日本神経学会学術集会. シンポジウム；運動ニューロン疾患の分子病態・治療法開発の最先端.
  • Place of Presentation: 新潟
  • Year and Date: 2015-05-22
• [Presentation] Modeling Parkinson’s Diease in Animals and iPS cells. (2015)
  • Author(s): Takahashi R,
  • Organizer: 2nd Taiwan international Congress of Parkinson’s Diease and Movement Disorders
  • Place of Presentation: Taipei, Taiwan
  • Year and Date: 2015-03-28
  • Invited
• [Presentation] 特発性正常圧水頭症はアルツハイマー病と異なるバイオマーカープロファイルを持つ疾患である (2015)
  • Author(s): 陣上直人、浅田めぐみ、植村健吾、能登理央、髙橋牧郎、尾崎彰彦、木原武士、 景山卓、髙橋良輔、下濱俊、木下彩栄
  • Organizer: 第16回日本正常圧水頭症学会
  • Place of Presentation: 岡山
  • Year and Date: 2015-02-28
• [Presentation] Screening of small molecules that down-regulate α-synuclein expression (2015)
  • Author(s): Takeshi Asano
  • Organizer: Alpha-Synuclein: The Gateway to Parkinsonism
  • Place of Presentation: Innsbruck
  • Year and Date: 2015-02-12
• [Presentation] Neuronopathic Gaucher’s disease model of medaka displayed axonal accumulation of alpha-synuclein (2014)
  • Author(s): Norihito Uemura, Masato Koike, Masato Kinoshita, Tomoko Fujiwara-Ishikawa, Hideaki Matsui, Hodaka Yamakado,Yasuo Uchiyama, Takeshi Todo, Shun-ichi Takeda, Ryosuke Takahashi
  • Organizer: 4th Asian and Oceanian Parkinson’s Disease and Movement Disorders Congress
  • Place of Presentation: Thailand
  • Year and Date: 2014-11-30
  • Invited
• [Presentation] Analysis of the ATP13A2mutant (PARK9) medaka (Oryzias latipes). (2014)
  • Author(s): 樽野陽亮、上村紀人、松井秀彰、山門穂高、高橋良輔
  • Organizer: 4th Asian and Oceanian Parkinson’s Disease and Movement Disorders Congress
  • Place of Presentation: タイ、パタヤ
  • Year and Date: 2014-11-30
• [Presentation] 孤発性パーキンソン病の遺伝的リスク因子を利用した新しいパーキンソン病モデルマウス作製の試み（ポスター） (2014)
  • Author(s): 生野真嗣、浅野剛史、山門穂高、高橋良輔
  • Organizer: 第8回パーキンソン病・運動障害疾患コングレス
  • Place of Presentation: 京都市
  • Year and Date: 2014-10-03
• [Presentation] ATP13A5 変異メダカの解析 (2014)
  • Author(s): 樽野陽亮、上村紀人、松井秀彰、山門穂高、高橋良輔
  • Organizer: 第8回パーキンソン病・運動障害疾患コングレス
  • Place of Presentation: 京都市
  • Year and Date: 2014-10-02
• [Presentation] ATP13A4 変異メダカの解析 (2014)
  • Author(s): 樽野陽亮、上村紀人、松井秀彰、山門穂高、高橋良輔
  • Organizer: 小型魚類研究会
  • Place of Presentation: 東京都
  • Year and Date: 2014-09-20
• [Presentation] ALSのTDP-43のinclusion形成におけるVon Hippel-Lindau proteinの役割 （ポスター） (2014)
  • Author(s): 内田 司、小代明美、守村敏史、辰己新水、高橋良輔、漆谷真
  • Organizer: 第37回日本神経科学学会
  • Place of Presentation: 横浜市
  • Year and Date: 2014-09-14
• [Presentation] GBA変異を有するパーキンソン病からの iPS 細胞の樹立 (2014)
  • Author(s): 陣上 直人,山門 穂高,小芝 泰,大江田 知子,澤田 秀幸,堀田 秋津,井上 治久,高橋 淳, 高橋 良輔
  • Organizer: 第37回日本神経科学大会
  • Place of Presentation: 横浜市
  • Year and Date: 2014-09-13
• [Presentation] ATP13A3 変異メダカの解析 (2014)
  • Author(s): 樽野陽亮、上村紀人、松井秀彰、山門穂高、高橋良輔
  • Organizer: 第37回日本神経科学学会
  • Place of Presentation: 横浜市
  • Year and Date: 2014-09-13
• [Presentation] Microarray analysis in spinal cords of sporadic ALS patients with cell-type specific transcriptome (2014)
  • Author(s): Hirofumi Yamashita, Okiru komine, Noriko Fujimori, Hidefumi Ito, Yohei Iguchi, Naoki Atsuta, Fumiaki Tanaka, Gen Sobue, Ryosuke Takahashi, Koji Yamanaka
  • Organizer: 第37回日本神経科学大会
  • Place of Presentation: 横浜市
  • Year and Date: 2014-09-13
• [Presentation] Creating mice models for sporadic Parkinson’s disease based on its genetic risk factors（ポスター） (2014)
  • Author(s): 生野真嗣、浅野剛史、山門穂高、高橋良輔
  • Organizer: 第37回日本神経科学大会
  • Place of Presentation: 横浜市
  • Year and Date: 2014-09-13
• [Presentation] The role of conformation of RNA recognition motifs of TDP-43 in the protein quality control system in ALS (2014)
  • Author(s): Makoto Urushitani
  • Organizer: 6th Japan-Canada joint symposium. 37th Annual Meeting of Japan Neuroscience Society
  • Place of Presentation: 横浜市
  • Year and Date: 2014-09-12
  • Invited
• [Presentation] パーキンソン病の治療に向けたα-シヌクレインの転写を抑制する低分子化合物のスクリーニング (2014)
  • Author(s): 浅野 剛史、山門 穂高、髙橋 良輔
  • Organizer: 第37回日本神経科学大会
  • Place of Presentation: 横浜市
  • Year and Date: 2014-09-12
• [Presentation] NF-κB経路を介したOptineurinのノックダウンによる神経細胞死 (2014)
  • Author(s): 秋月真由美、山下博文、植村健吾、丸山博文、川上秀史、伊東秀文、高橋良輔
  • Organizer: 第37回日本神経科学大会
  • Place of Presentation: 横浜市
  • Year and Date: 2014-09-12
• [Presentation] Alpha-synuclein accumulation in Gaucher disease model of medaka does not contribute to neurodegeneration (2014)
  • Author(s): Norihito Uemura, Tomoko Fujiwara-Ishikawa, Masato Kinoshita, Masato Koike, Hideaki Matsui, Hodaka Yamakado, Yasuo Uchiyama, Takeshi Todo, Shun-ichi Takeda and Ryosuke Takahashi
  • Organizer: 第37回日本神経科学大会
  • Place of Presentation: 横浜市
  • Year and Date: 2014-09-12
• [Presentation] iPS細胞モデルによるLRRK2 I2020T 変異パーキンソン病の研究 (2014)
  • Author(s): 小芝泰、森実飛鳥、山門穂高、菊地哲広、陣上直人、土井大輔、長谷川一子、井上治久、髙橋淳、髙橋良輔
  • Organizer: 第37回日本神経科学大会
  • Place of Presentation: 横浜市
  • Year and Date: 2014-09-12
• [Presentation] 血管性認知症におけるペリサイトとBMPに関する研究 （タイトル：BMP-4 expression by immature pericytes correlates with white matter damage.) (2014)
  • Author(s): 上村麻衣子、猪原匡史、中込隆之、松山知弘、長束一行、木下彩栄、高橋良輔
  • Organizer: 第37回神経科学大会
  • Place of Presentation: 横浜市
  • Year and Date: 2014-09-12
• [Presentation] Gene Expression Profiling in Motor Neuron-Specific 26S Proteasome Conditional Knockout Mice. (2014)
  • Author(s): Hoshino T, Yamashita H, Tashiro Y, Misawa H, Takahashi R
  • Organizer: 第37回神経科学大会
  • Place of Presentation: 横浜市
  • Year and Date: 2014-09-12
• [Presentation] ALSのTDP-43のinclusion形成におけるVon Hippel-Lindau proteinの役割 (2014)
  • Author(s): 内田 司、小代 明美、守村 敏史、辰巳 新水、高橋 良輔、漆谷 真
  • Organizer: 第37回日本神経科学大会
  • Place of Presentation: 横浜市
  • Year and Date: 2014-09-11
• [Presentation] VHL, a modifier of degradation, aggregation and compartmentation of TDP-43 in ALS pathology. (2014)
  • Author(s): 内田 司、小代 明美、玉木 良高、辰巳 新水、 守村 敏史、 高橋 良輔、 漆谷 真
  • Organizer: 第37回日本神経科学学会
  • Place of Presentation: 横浜市
  • Year and Date: 2014-09-11
• [Presentation] Chemical library screening to identify a small compound that promotes motor neurons differentiation from iPSCs/ESCs (2014)
  • Author(s): 後藤和也、今村恵子、三谷幸之介、饗庭一博、中辻憲夫、髙橋良輔、井上治久
  • Organizer: 第37回神経科学大会
  • Place of Presentation: 横浜市
  • Year and Date: 2014-09-11
• [Presentation] Analysis of effect of neuroprotective agents on oxidative stress in association with Alzheimer’s disease in vitro (2014)
  • Author(s): 宮本将和、小形美果、浅田めぐみ、下濱俊、髙橋良輔、植村健吾、木下彩栄
  • Organizer: 第37回神経科学大会
  • Place of Presentation: 横浜市
  • Year and Date: 2014-09-11
• [Presentation] Increased synaptic density and improved spatial working memory in N-cadherin shedding deficient knock-in mice Nカドヘリン切断阻害マウスはシナプス密度と空間作業記憶が向上する (2014)
  • Author(s): 浅田めぐみ、久保田正和、野田秦葉、上田奈津実、諏訪あゆみ、田代喜崇、上村麻衣子、山門 穂高、下濱俊、高橋良輔、植村健吾、木下専、木下彩栄
  • Organizer: 第37回神経科学大会
  • Place of Presentation: 横浜市
  • Year and Date: 2014-09-11
• [Presentation] Chemical library screening to identify a small compound that promotes motor neurons differentiation from iPSCs/ESCs (2014)
  • Author(s): Kazuya Goto
  • Organizer: CSHA
  • Place of Presentation: 蘇州
  • Year and Date: 2014-08-26
• [Presentation] GBA変異メダカは軸索内にalpha-synucleinを蓄積する (2014)
  • Author(s): 上村紀仁、石川智子、木下政人、小池正人、松井秀彰、山門穂高、内山安男、藤堂剛、武田俊一、髙橋良輔
  • Organizer: 第23回日本Cell Death学会学術集会
  • Place of Presentation: 東京都
  • Year and Date: 2014-07-18
• [Presentation] 運動ニューロン特異的26Sプロテアソームノックアウトマウスの遺伝子網羅的解析 (2014)
  • Author(s): 星野 友則, 山下 博史, 田代 善崇, 三澤 日出巳, 高橋良輔
  • Organizer: 日本Cell death 学会
  • Place of Presentation: 東京都
  • Year and Date: 2014-07-18
• [Presentation] Involvement of iron in the pathogenesis of Parkinson’s disease (2014)
  • Author(s): Takeshi Asano
  • Organizer: MDS-AOS Basic Scientists Summer School
  • Place of Presentation: 台北
  • Year and Date: 2014-07-14
• [Presentation] Microarray analysis in spinal cords of sporadic ALS patients with cell-type specific transcriptome (2014)
  • Author(s): Hirofumi Yamashita, Noriko Fujimori, Hidefumi Ito, Yohei Iguchi, Naoki Atsuta, Fumiaki Tanaka, Gen Sobue, Ryosuke Takahashi, Koji Yamanaka
  • Organizer: Nucleic Acid Summit
  • Place of Presentation: San Diego
  • Year and Date: 2014-06-19
• [Presentation] 運動ニューロン特異的26Sプロテアソームノックアウトマウスの遺伝子網羅的解析 (2014)
  • Author(s): 星野 友則, 山下 博史, 田代 善崇, 三澤 日出巳, 高橋良輔
  • Organizer: 第55回日本神経病理学会総会学術研究会
  • Place of Presentation: 東京都
  • Year and Date: 2014-06-06
• [Presentation] 孤発性パーキンソン病の遺伝的リスク因子を利用した新しいモデルマウス作製の試み（ポスター） (2014)
  • Author(s): 生野真嗣
  • Organizer: 第55回日本神経学会学術大会
  • Place of Presentation: 福岡市
  • Year and Date: 2014-05-24
• [Presentation] Therapeutic approach to Parkinson’s disease by modifying α-synuclein transcription (2014)
  • Author(s): Yamakado H, Asano T, Takahashi R.
  • Organizer: 第55回日本神経学会学術大会
  • Place of Presentation: 福岡市
  • Year and Date: 2014-05-24
• [Presentation] マウスを用いたin vivoにおけるゾニサミドの作用機構 (2014)
  • Author(s): 浅野 剛史、山門 穂高、高橋 良輔
  • Organizer: 第55回日本神経学会学術大会
  • Place of Presentation: 福岡市
  • Year and Date: 2014-05-24
• [Presentation] GBA変異メダカは脳にalpha-synuclein凝集体を形成する (2014)
  • Author(s): 上村紀仁、石川智子、木下政人、小池正人、松井秀彰、山門穂高、植村健吾、内山安男、藤堂剛、武田俊一、髙橋良輔
  • Organizer: 第55回日本神経学会学術大会
  • Place of Presentation: 福岡市
  • Year and Date: 2014-05-24
• [Presentation] NF-κB経路を介したOptineurinのノックダウンによる神経細胞死 (2014)
  • Author(s): 秋月真由美、山下博文、植村健吾、丸山博文、川上秀史、伊東秀文、高橋良輔
  • Organizer: 第55回日本神経学会学術大会
  • Place of Presentation: 福岡市
  • Year and Date: 2014-05-23
• [Presentation] 培養細胞モデルを用いたALSにおけるTDP-43の分子的機構の解析（ポスター） (2014)
  • Author(s): 内田 司
  • Organizer: 第55回日本神経学会学術大会
  • Place of Presentation: 福岡市
  • Year and Date: 2014-05-23
• [Presentation] ATP13A2 変異メダカの解析 (2014)
  • Author(s): 樽野陽亮、上村紀人、松井秀彰、山門穂高、高橋良輔
  • Organizer: 第55回 日本神経学会学術大会
  • Place of Presentation: 福岡市
  • Year and Date: 2014-05-23
• [Presentation] Aβ,細胞死への酸化ストレスの影響に対する神経保護物質の抵抗性のin vitroでの検証 (2014)
  • Author(s): 宮本将和、小形美果、渡邉究、浅田めぐみ、植村健吾、高橋良輔、木下彩栄
  • Organizer: 第55回 日本神経学会学術大会
  • Place of Presentation: 福岡市
  • Year and Date: 2014-05-23
• [Presentation] 血管性認知症におけるペリサイトとBMPに関する研究 （タイトル：BMP-4 expression by immature pericytes correlates with white matter damage.) (2014)
  • Author(s): 上村麻衣子、猪原匡史、中込隆之、松山知弘、長束一行、木下彩栄、高橋良輔
  • Organizer: 第55回 日本神経学会学術大会
  • Place of Presentation: 福岡市
  • Year and Date: 2014-05-23
• [Presentation] iPS細胞モデルによるLRRK2 I2020T 変異パーキンソン病の研究 (2014)
  • Author(s): 小芝泰、森実飛鳥、菊地哲広、山門穂高、陣上直人、土井大輔、西村周泰、皆川栄子、江川斉宏、井上治久、髙橋淳、髙橋良輔
  • Organizer: 第55回日本神経学会学術総会
  • Place of Presentation: 福岡市
  • Year and Date: 2014-05-22
• [Presentation] Optineurin suppression causes neuronal cell death via NF-κB pathway (2014)
  • Author(s): Mayumi Akizuki, Hirofumi Yamashita, Kengo Uemura, Hirofumi Maruyama, Hideshi Kawakami, Hidefumi Ito, Ryosuke Takahashi
  • Organizer: 14th asian ＆ oceanian congress of Neurology
  • Place of Presentation: マカオ
  • Year and Date: 2014-03-02 – 2014-03-05
• [Presentation] Bone morphogenic protein expression in pericytes is a pathological correlate of vascular cognitive impariment） (2014)
  • Author(s): 上村麻衣子、猪原匡史、長束一行、木下彩栄、高橋良輔
  • Organizer: International Stroke Conference 2014
  • Place of Presentation: アメリカ、サンディエゴ
  • Year and Date: 2014-02-13
• [Presentation] ADAM10切断阻害変異導入N-カドヘリンマウスの解析 (2013)
  • Author(s): 浅田めぐみ、久保田正和、野田泰葉、上田奈津実、諏訪あゆみ、田代善崇、山門穂高、下濱俊、高橋良輔、植村健吾、木下専、木下彩栄
  • Organizer: 第36回 日本分子生物学会
  • Place of Presentation: 神戸市
  • Year and Date: 2013-12-05
• [Presentation] PINK1とParkinは脊椎動物において相補的にミトコンドリアを保護する (2013)
  • Author(s): 浅野 剛史、松井 秀彰、 Robert Gavinio、上村紀人、伊東秀文、谷口善仁、Jie Shen、武田 俊一、植村 健吾、山門 穂高、髙橋 良輔
  • Organizer: 第３６回 日本分子生物学会
  • Place of Presentation: 神戸市
  • Year and Date: 2013-12-04
• [Presentation] Neurodegeneration, molecular mechanism, Parkinson's diease, animal model, medaka, mouse. (2013)
  • Author(s): Ryosuke Takahashi
  • Organizer: Swiss-Kyoto Symposium
  • Place of Presentation: 京都市
  • Year and Date: 2013-11-22
  • Invited
• [Presentation] NF-κB経路を介したOptineurinのノックダウンによる神経細胞死 (2013)
  • Author(s): 20.秋月真由美、山下博文、植村健吾、丸山博文、川上秀史、伊東秀文、高橋良輔
  • Organizer: Neuro2013
  • Place of Presentation: 京都市
  • Year and Date: 2013-11-12
• [Presentation] Viable Gaucher's disease model of medaka fish completely deficienct in glucocerebrosidase activity developed alpha-synuclein aggregation in the brain (2013)
  • Author(s): Norihito Uemura, Tomoko Fujiwara-Ishikawa, Masato Kinoshita, Masato Koike, Hideaki Matsui, Hodaka Yamakado, Kengo Uemura, Yasuo Uchiyama, Takeshi Todo, Shun-ichi Takeda and Ryosuke Takahashi
  • Organizer: Neuroscience 2013
  • Place of Presentation: SanDiego
  • Year and Date: 2013-11-10
• [Presentation] Exploring the molecular mechanism underlying Parkinson's diease with genetic medaka models. (2013)
  • Author(s): Ryosuke Takahashi
  • Organizer: International Symposium on Mitochondria 2013
  • Place of Presentation: 東京都
  • Year and Date: 2013-11-06
  • Invited
• [Presentation] ATP13A2変異メダカの解析 (2013)
  • Author(s): 樽野陽亮、谷口善仁、松井秀彰、上村紀仁、山門穂高、高橋良輔
  • Organizer: 第７回パーキンソン病・運動障害疾患コングレス
  • Place of Presentation: 東京都
  • Year and Date: 2013-10-11
• [Presentation] マウスを用いたゾニサミドの作用機序の解析 (2013)
  • Author(s): 浅野剛史、山門穂高、高橋良輔
  • Organizer: 第７回 パーキンソン病・運動障害疾患コングレス
  • Place of Presentation: 東京都
  • Year and Date: 2013-10-11
• [Presentation] 疾患特異的iPS細胞モデルによるLRRK2変異パーキンソン病の研究 (2013)
  • Author(s): 小芝泰、森実飛鳥、山門穂高、陣上直人、菊地哲広、土井大輔、皆川栄子、江川斉宏、井上治久、髙橋淳、髙橋良輔
  • Organizer: 第７回パーキンソン病・運動障害疾患コングレス
  • Place of Presentation: 東京都
  • Year and Date: 2013-10-10 – 2013-10-12
• [Presentation] NF-κB経路を介したOptineurinのノックダウンによる神経細胞死 (2013)
  • Author(s): 秋月真由美、山下博文、植村健吾、丸山博文、川上秀史、伊東秀文、高橋良輔
  • Organizer: 第22回日本cell death学会学術集会
  • Place of Presentation: 京都市
  • Year and Date: 2013-07-19
• [Presentation] PINK1とParkinは脊椎動物において相補的にミトコンドリアを保護する (2013)
  • Author(s): 浅野 剛史、松井 秀彰、 Robert Gavinio、上村 紀人、伊東 秀文、谷口 善仁、Jie Shen、武田 俊一、植村 健吾、山門 穂高、髙橋 良輔
  • Organizer: 第22回日本Cell Death学会学術集会
  • Place of Presentation: 京都市
  • Year and Date: 2013-07-19
• [Presentation] GBAノックアウトメダカは脳にアルファシヌクレイン凝集体を形成する (2013)
  • Author(s): 上村紀仁、石川智子、木下政人、小池正人、松井秀彰、山門穂高、植村健吾、内山安男、藤堂剛、武田俊一、高橋良輔
  • Organizer: 第22回日本Cell Death学会学術集会
  • Place of Presentation: 京都市
  • Year and Date: 2013-07-19
• [Presentation] Viable Gaucher's disease model of medaka fish completely deficienct in glucocerebrosidase activity developed alpha-synuclein aggregation in the brain (2013)
  • Author(s): Norihito Uemura, Tomoko Fujiwara-Ishikawa, Masato Kinoshita, Masato Koike, Hideaki Matsui, Hodaka Yamakado, Kengo Uemura, Yasuo Uchiyama, Takeshi Todo, Shun-ichi Takeda and Ryosuke Takahashi
  • Organizer: 日本神経科学学会
  • Place of Presentation: 京都市
  • Year and Date: 2013-06-22
• [Presentation] ATP13A2変異メダカの解析 (2013)
  • Author(s): 樽野陽亮、谷口善仁、松井秀彰、上村紀仁、山門穂高、高橋良輔
  • Organizer: 日本神経科学学会
  • Place of Presentation: 京都市
  • Year and Date: 2013-06-22
• [Presentation] Microarray analysis in spinal cords of sporadic ALS patients with cell-type specific transcriptome. (2013)
  • Author(s): Hirofumi Yamashita, Noriko Fujimori, Hidefumi Ito, Yohei Iguchi, Naoki Atsuta, Fumiaki Tanaka, Gen Sobue, Ryosuke Takahashi, Koji Yamanaka.
  • Organizer: Neuro2013
  • Place of Presentation: 京都市
  • Year and Date: 2013-06-21
• [Presentation] 疾患特異的iPS細胞モデルによる遺伝性パーキンソン病の研究 (2013)
  • Author(s): 小芝泰、森実飛鳥、山門穂高、菊地哲広、土井大輔、西村周泰、皆川栄子、江川斉宏、近藤孝之、井上治久、髙橋淳、髙橋良輔
  • Organizer: 第３６回日本神経科学大会
  • Place of Presentation: 京都市
  • Year and Date: 2013-06-20 – 2013-06-23
• [Presentation] Viable Gaucher's disease model of medaka fish completely deficienct in glucocerebrosidase activity developed alpha-synuclein aggregation in the brain (2013)
  • Author(s): Norihito Uemura, Tomoko Fujiwara-Ishikawa, Masato Kinoshita, Masato Koike, Hideaki Matsui, Hodaka Yamakado, Kengo Uemura, Yasuo Uchiyama, Takeshi Todo, Shun-ichi Takeda and Ryosuke Takahashi
  • Organizer: 17th international congress of Parkinson's disease and movement disorders
  • Place of Presentation: Ｓｙｄｎｅｙ
  • Year and Date: 2013-06-20
• [Presentation] α-Synucleinの発現量の調節を標的とするパーキンソン病治療薬剤のスクリーニング (2013)
  • Author(s): 浅野剛史、山門穂高、高橋良輔
  • Organizer: Neuro2013
  • Place of Presentation: 京都市
  • Year and Date: 2013-06-20
• [Presentation] ADAM10 切断阻害変異導入N-カドヘリンマウスの解析 (2013)
  • Author(s): 浅田めぐみ、諏訪あゆみ、久保田正和、野田泰葉、田代善崇、前迫真人、山門穂高、下濱俊、高橋良輔、植村健吾、木下彩栄
  • Organizer: Neuro2013
  • Place of Presentation: 京都市
  • Year and Date: 2013-06-20
• [Presentation] Therapeutic approach to Parkinson's disease by modifying α-synuclein expression. (2013)
  • Author(s): Yamakado H, Asano T, Takahashi, R
  • Organizer: The MDS 17th International Congress of Parkinson's Disease and Movement Disorders
  • Place of Presentation: Sydney
  • Year and Date: 2013-06-17
• [Presentation] メダカを用いたGBA変異とパーキンソン病の関連性の解析 (2013)
  • Author(s): 上村紀仁、石川智子、木下政人、小池正人、松井秀彰、山門穂高、植村健吾、内山安男、藤堂剛、武田俊一、高橋良輔
  • Organizer: 日本神経学会
  • Place of Presentation: 東京都
  • Year and Date: 2013-05-31
• [Presentation] ATP13A2変異メダカの解析 (2013)
  • Author(s): 樽野陽亮、谷口善仁、松井秀彰、上村紀仁、山門穂高、高橋良輔
  • Organizer: 第５４回日本神経学会学術大会
  • Place of Presentation: 東京都
  • Year and Date: 2013-05-31
• [Presentation] 疾患特異的iPS細胞モデルによる遺伝性パーキンソン病の研究 (2013)
  • Author(s): 小芝泰、森実飛鳥、山門穂高、菊地哲広、皆川栄子、土井大輔、西村周泰、江川斉宏、井上治久、髙橋淳、髙橋良輔
  • Organizer: 第54回日本神経学会学術総会
  • Place of Presentation: 東京都
  • Year and Date: 2013-05-29 – 2013-06-01
• [Presentation] Regulation of the PINK1 signaling by a mitochondrial protein PGAM5. (2012)
  • Author(s): Sawada T
  • Organizer: Neuroscience 2012
  • Place of Presentation: New Orleans, U.S.A
  • Year and Date: 2012-10-15
• [Presentation] BACテクノロジーを用いたパーキンソン病の治療薬候補の探索 (2012)
  • Author(s): 浅野剛史
  • Organizer: 第6回パーキンソン病・運動障害疾患コングレス
  • Place of Presentation: 京都ホテルオ-クラ
  • Year and Date: 2012-10-13
• [Presentation] α-synuclein BAC transgenic mice as a model for Parkinson’s disease manifested decreased anxiety-like behavior. (2012)
  • Author(s): Yamakado H
  • Organizer: The MDS 17th International Congress of Parkinson's Disease and Movement Disorders
  • Place of Presentation: Dablin, Ireland
  • Year and Date: 2012-06-21
• [Presentation] CONGNITIVE AND PHYCHIATRIC FEATURES IN ANIMAL PD MODELS. (2012)
  • Author(s): Takahashi R
  • Organizer: 8th International Congress On Mental Dysfunction Other Non-Motor Features In Parkinson’s Diease and Related Disorders
  • Place of Presentation: Berlin, Germany
  • Year and Date: 2012-05-04
  • Invited
• [Presentation] Regulation of the PINK1 signaling by a mitochondrial protein PGAM5.
  • Author(s): Sawada T
  • Organizer: Neuroscience 2012
  • Place of Presentation: New Orleans, U.S.A.
• [Presentation] BACテクノロジーを用いたパーキンソン病の治療薬候補の探索
  • Author(s): 浅野剛史
  • Organizer: 第6回パーキンソン病・運動障害疾患コングレス
  • Place of Presentation: 京都ホテルオークラ
• [Presentation] CONGNITIVE AND PHYCHIATRIC FEATURES IN ANIMAL PD MODELS.
  • Author(s): Takahashi R
  • Organizer: 8th International Congress On Mental Dysfunction & Other Non-Motor Features In Parkinson’s Diease and Related Disorders.
  • Place of Presentation: Berlin, Germany
  • Invited
• [Book] 医学のあゆみ (2015)
  • Author(s): 山下博史、漆谷 真
  • Total Pages: 70
  • Publisher: 医歯薬出版
• [Book] medicina (2014)
  • Author(s): 山下博史、高橋良輔
  • Total Pages: 5
  • Publisher: 医学書院
• [Book] Frontiers in Parkinson Diease (2014)
  • Author(s): 浅野剛史
  • Total Pages: 54
  • Publisher: メディカルレビュー社
• [Book] 医学のあゆみ (2014)
  • Author(s): 山下博史、漆谷真
  • Total Pages: 10
  • Publisher: 医歯薬出版
• [Book] 神経疾患 最新の治療2015－2017 (2014)
  • Author(s): 陣上直人、高橋良輔
  • Total Pages: 301
  • Publisher: 南江堂
• [Book] ミスフォールド蛋白質による神経細胞死と治療戦略. (2013)
  • Author(s): 守村 敏史、高橋 良輔、漆谷 真
  • Total Pages: 44
  • Publisher: メディカルドゥ
• [Book] Medical Science Digest 39巻 (2013)
  • Author(s): 高橋良輔
  • Publisher: ニューサイエンス社
• [Book] 変性疾患【１）鉄と神経変性疾患】 (2013)
  • Author(s): 浅野剛史、高橋良輔
  • Publisher: 神経 5巻
• [Book] 脳21 16巻(1) (2013)
  • Author(s): 澤田知世、今居 譲、高橋良輔
  • Publisher: 金芳堂
• [Book] Annual Review神経 2013 (2013)
  • Author(s): 糸数隆秀、高橋良輔、山下俊英
  • Total Pages: 278
  • Publisher: 中外医学社
• [Book] Amyotrophic Lateral Sclerosis: Symptoms, Treatment and Prognosis. (2013)
  • Author(s): Urushitani M and Morimura T
  • Total Pages: 24
  • Publisher: Nova Science Publishers, Inc.
• [Book] すべてがわかる筋委縮性側索硬化症・運動ニューロン疾患 (2013)
  • Author(s): 漆谷 真
  • Total Pages: 384
  • Publisher: 中山書店
• [Book] 臨床神経学 (2013)
  • Author(s): Takahashi R.
  • Publisher: Societas Neurologica Japonica
• [Book] 日本内科学会雑誌 (2013)
  • Author(s): Kondo T, Inoue H, Takahashi R.
  • Total Pages: 2015
  • Publisher: 日本内科学会
• [Book] 孤発性パーキンソン病におけるiPS細胞研究 (2013)
  • Author(s): 小芝泰、高橋良輔
  • Total Pages: 4
  • Publisher: 医学のあゆみ
• [Remarks] 「脳内環境：恒常性維持機構とその破綻」
  • URL: http://www.neurol.med.kyoto-u.ac.jp/brainenvironment/#
• [Remarks] 脳内環境：恒常性維持機構とその破綻
  • URL: http://www.neurol.med.kyoto-u.ac.jp/brainenvironment/#
• [Remarks] 脳内環境
  • URL: http://www.neurol.med.kyoto-u.ac.jp/brainenvironment/#
• [Remarks] 脳内環境
  • URL: http://www.neurol.med.kyoto-u.ac.jp/brainenvironment/#