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The function of non-coding DNA for genome integrity

Administrative Group

Project AreaFunctions of non-coding DNA region for genome integrity
Project/Area Number 23114001
Research Category

Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)

Allocation TypeSingle-year Grants
Review Section Biological Sciences
Research InstitutionThe University of Tokyo (2015)
National Institute of Genetics

Principal Investigator

Kobayashi Takehiko  東京大学, 分子細胞生物学研究所, 教授 (40270475)

Co-Investigator(Kenkyū-buntansha) NAKAYAMA Jun-ichi  名古屋市立大学, 大学院システム自然科学研究科, 教授 (60373338)
OHTA Kunihiro  東京大学, 大学院総合文化研究科, 教授 (90211789)
Co-Investigator(Renkei-kenkyūsha) INNAN Hideki  総合研究大学院大学, 先導科学研究科, 准教授 (90444140)
KAJIKAWA Masaki  東京工業大学, 大学院生命理工学研究科研究科, 講師 (90361766)
HISHIDA Takashi  学習院大学, 理学部, 教授 (60335388)
Masumoto Hiroshi  公益財団法人かずさDNA研究所, 先端研究部, 室長 (70229384)
KANOH Junko  大阪大学, 蛋白質研究所, 准教授 (10323809)
TAKATA Minoru  京都大学, 放射線生物研究センター, 教授 (30281728)
Project Period (FY) 2011-04-01 – 2016-03-31
Project Status Completed (Fiscal Year 2015)
Budget Amount *help
¥110,630,000 (Direct Cost: ¥85,100,000、Indirect Cost: ¥25,530,000)
Fiscal Year 2015: ¥8,190,000 (Direct Cost: ¥6,300,000、Indirect Cost: ¥1,890,000)
Fiscal Year 2014: ¥8,190,000 (Direct Cost: ¥6,300,000、Indirect Cost: ¥1,890,000)
Fiscal Year 2013: ¥8,710,000 (Direct Cost: ¥6,700,000、Indirect Cost: ¥2,010,000)
Fiscal Year 2012: ¥8,580,000 (Direct Cost: ¥6,600,000、Indirect Cost: ¥1,980,000)
Fiscal Year 2011: ¥76,960,000 (Direct Cost: ¥59,200,000、Indirect Cost: ¥17,760,000)
Keywords非コードDNA / インターメア / ゲノム / 染色体 / ゲノムの安定性 / テロメア / クロマチン / セントロメア / 非コードDNA領域 / クロマチン構造 / 反復配列 / クロマチンネットワーク / 非コード機能配列 / 連携研究 / 細胞老化 / 組換え / 出芽酵母 / リボソームRNA遺伝子
Outline of Final Research Achievements

The organizing group provided support and evaluation to the research projects, and educated Ph.D students, young researchers and postdoctoral fellows. The group held the scientific meetings to discuss the individual research projects and promote collaboration among the members in this research area twice a year. The organizing group supported research activities by organizing research equipments as “Technology hubs” and held the training courses. In order to notice the scientific achievement to the public, the organizing group established the web site where every one can access our activities including publications. A small booklet “News Letter” was distributed twice a year to introduce our important achievements. In addition to domestic scientific meetings, we held two international symposiums with several distinguished scientists invited from abroad. Finally, a book “INTERMERE-as a operator of chromosome” that introduces our achievements was published by the KAGAKUDOUJIN.

Report

(6 results)
  • 2015 Annual Research Report   Final Research Report ( PDF )
  • 2014 Annual Research Report
  • 2013 Annual Research Report
  • 2012 Annual Research Report
  • 2011 Annual Research Report
  • Research Products

    (125 results)

All 2016 2015 2014 2013 2012 2011 Other

All Journal Article (39 results) (of which Int'l Joint Research: 1 results,  Peer Reviewed: 39 results,  Open Access: 11 results,  Acknowledgement Compliant: 9 results) Presentation (49 results) (of which Int'l Joint Research: 4 results,  Invited: 28 results) Book (16 results) Remarks (16 results) Patent(Industrial Property Rights) (4 results) Funded Workshop (1 results)

  • [Journal Article] More than 10% of yeast genes are related to genome stability and influence cellular senescence via rDNA maintenance2016

    • Author(s)
      Kimiko Saka, Akihiro Takahashi, Mariko Sasaki and Takehiko Kobayashi
    • Journal Title

      Nucleic Acids Research

      Volume: in press Issue: 9 Pages: 1-11

    • DOI

      10.1093/nar/gkw110

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Extended string-like binding of the phosphorylated HP1α N-terminal tail to the lysine 9-methylated histone H3 tail.2016

    • Author(s)
      Shimojo H, Kawaguchi A, Oda T, Hashiguchi N, Omori S, Moritsugu K, Kidera A, Hiragami-Hamada K, Nakayama J, Sato M, Nishimura Y.
    • Journal Title

      Sci Rep.

      Volume: 6 Issue: 1 Pages: 22527-22527

    • DOI

      10.1038/srep22527

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Gic1 is a novel heterochromatin boundary protein in vivo.2016

    • Author(s)
      Mitsumori R, Shinmyozu K, Nakayama J, Uchida H, Oki M.
    • Journal Title

      Genes Genet Syst.

      Volume: in press

    • NAID

      130005170330

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] The Human PolI Transcription Terminator Complex Acts as a Replication Fork Barrier that Coordinates the Progress of Replication with rRNA Transcription Activity.2015

    • Author(s)
      Akamatsu Y, Kobayashi T.
    • Journal Title

      Mol Cell Biol.

      Volume: 35 Issue: 10 Pages: 1871-1881

    • DOI

      10.1128/mcb.01521-14

    • Related Report
      2015 Annual Research Report 2014 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Glycerophospholipid regulation of modality-specific sensory axon guidance in the spinal cord.2015

    • Author(s)
      Guy AT, Nagatsuka Y, Ooashi N, Inoue M, Nakata A, Greimel P, Inoue A, Nabetani T, Murayama A, Ohta K, Ito Y, Aoki J, Hirabayashi Y, Kamiguchi H
    • Journal Title

      Science

      Volume: 349 Issue: 6251 Pages: 974-977

    • DOI

      10.1126/science.aab3516

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] Dynamic transition of transcription and chromatin landscape during fission yeast adaptation to glucose starvation2015

    • Author(s)
      Oda A, Takemata N, Hirata Y, Miyoshi T, Suzuki Y, Sugano S, and Ohta K
    • Journal Title

      Genes to Cells

      Volume: 5 Issue: 5 Pages: 392-407

    • DOI

      10.1111/gtc.12229

    • Related Report
      2015 Annual Research Report 2014 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Environmental factors that affect pupation decision in the horned flour beetle Gnatocerus cornutus2015

    • Author(s)
      Takane Ozawa, Kunihiro Ohta, Masakazu Shimada, Kensuke Okada, Yasukazu Okada
    • Journal Title

      Zoological Science

      Volume: 32 Issue: 2 Pages: 183-187

    • DOI

      10.2108/zs140203

    • Related Report
      2015 Annual Research Report 2014 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Antagonistic controls of chromatin and mrna start site selection by Tup family corepressors and the CCAAT-binding factor.2015

    • Author(s)
      Asada R, Takemata N, Hoffman CS, Ohta K, Hirota K.
    • Journal Title

      Mol Cell Biol.

      Volume: 35 Issue: 5 Pages: 847-855

    • DOI

      10.1128/mcb.00924-14

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Ribosomal RNA gene repeats, their stability and cellular senescence2014

    • Author(s)
      Kobayashi T
    • Journal Title

      Proceedings of the Japan Academy, Series B

      Volume: 90 Issue: 4 Pages: 119-129

    • DOI

      10.2183/pjab.90.119

    • NAID

      130003392358

    • ISSN
      0386-2208, 1349-2896
    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Population genomics of the fission yeast Schizosaccharomyces pombe2014

    • Author(s)
      Jeffrey A. Fawcett, Tetsushi Iida, Shohei Takuno, Ryuichi P. Sugino, Tomoyuki Kado, Kazuto Kugou, Sachiko Mura, Takehiko Kobayashi, Kunihiro Ohta, Jun-ichi Nakayama, Hideki Innan
    • Journal Title

      PLOS ONE

      Volume: 9 Issue: 8 Pages: e104241-e104241

    • DOI

      10.1371/journal.pone.0104241

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] N-terminal phosphorylation of HP1α increases its nucleosome-binding specificity.2014

    • Author(s)
      Nishibuchi G, Machida S, Osakabe A, Murakoshi H, Hiragami-Hamada K, Nakagawa R, Fischle W, Nishimura Y, Kurumizaka H, Tagami H, Nakayama JI.
    • Journal Title

      Nucleic Acids Res.

      Volume: 42 Issue: 20 Pages: 12498-12511

    • DOI

      10.1093/nar/gku995

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Physical and Functional Interactions between the Histone H3K4 Demethylase KDM5A and the Nucleosome Remodeling and Deacetylase (NuRD) Complex.2014

    • Author(s)
      Nishibuchi G, Shibata Y, Hayakawa T, Hayakawa N, Ohtani Y, Shinmyozu K, Tagami H, Nakayama JI.
    • Journal Title

      J Biol Chem.

      Volume: 289 Issue: 42 Pages: 28956-28970

    • DOI

      10.1074/jbc.m114.573725

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Biochemical and structural properties of heterochromatin protein 1: understanding its role in chromatin assembly.2014

    • Author(s)
      Nishibuchi G, Nakayama J
    • Journal Title

      J Biochem

      Volume: 56 Issue: 1 Pages: 11-20

    • DOI

      10.1093/jb/mvu032

    • NAID

      40020124382

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Ribosomal DNA and cellular senescence: new evidence supporting the connection between rDNA and aging.2014

    • Author(s)
      Ganley, A.R., and Kobayashi, T.
    • Journal Title

      FEMS Yeast Res.

      Volume: 14 Issue: 1 Pages: 49-59

    • DOI

      10.1111/1567-1364.12133

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Cellular senescence in yeast is regulated by rDNA noncoding transcription.2013

    • Author(s)
      Saka, K., Ide, S., Ganley, A.R., and Kobayashi, T.
    • Journal Title

      Curr. Biol.

      Volume: 23 Issue: 18 Pages: 1794-1798

    • DOI

      10.1016/j.cub.2013.07.048

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Rtt109 prevents hyper-amplification of ribosomal RNA genes through histone modification in budding yeast2013

    • Author(s)
      Ide S, Saka K, Kobayashi T.
    • Journal Title

      PLoS Genet

      Volume: 9 Issue: 4 Pages: e1003410-e1003410

    • DOI

      10.1371/journal.pgen.1003410

    • Related Report
      2013 Annual Research Report 2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Single Cell Visualization of Yeast Gene Expression Shows Correlation of Epigenetic Switching Between Multiple Heterochromatic Regions Through Multiple Generations2013

    • Author(s)
      Yasunobu Mano, Tetsuya J. Kobayashi, Jun-ichi Nakayama, Hiroyuki Uchida, Masaya Oki
    • Journal Title

      Plos Biology

      Volume: 11 Issue: 7 Pages: e1001601-e1001601

    • DOI

      10.1371/journal.pbio.1001601

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] C-terminus of the Sgf73 subunit of SAGA and SLIK is important for retention in the larger complex and for heterochromatin boundary function.2013

    • Author(s)
      Kamata K, Hatanaka A, Goswami G, Shinmyozu K, Nakayama JI, Urano T, Hatashita M, Uchida H, Oki M.
    • Journal Title

      Genes cells

      Volume: 9 Issue: 9 Pages: 823-837

    • DOI

      10.1111/gtc.12075

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Spt6 prevents transcription-coupled loss of posttranslationally modified histone H3.2013

    • Author(s)
      Kato H, Okazaki K, Iida T, Nakayama J, Murakami Y, Urano T.
    • Journal Title

      Sci Rep.

      Volume: 3 Issue: 1 Pages: 2186-2186

    • DOI

      10.1038/srep02186

    • NAID

      120006539377

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Initiation of meiotic recombination in chromatin structure2013

    • Author(s)
      山田貴富、太田邦史
    • Journal Title

      J. Biochem.

      Volume: 154 Issue: 2 Pages: 107-114

    • DOI

      10.1093/jb/mvt054

    • NAID

      40019731054

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Stress-induced lncRNAs evade nuclear degradation and enter the translational machinery2013

    • Author(s)
      Galipon, Josephine ; Miki, Atsuko ; Oda, Arisa ; Inada, Toshifumi ; Ohta, Kunihiro
    • Journal Title

      Genes to Cells

      Volume: 18 Issue: 5 Pages: 353-368

    • DOI

      10.1111/gtc.12042

    • Related Report
      2013 Annual Research Report 2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Acetylated Histone H3K9 is associated with meiotic recombination hotspots, and plays a role in recombination redundantly with other factors including the H3K4 methylase Setl in fission yeast.2013

    • Author(s)
      山田真太郎
    • Journal Title

      Nucleic Acids Research

      Volume: 41 Issue: 6 Pages: 3504-3517

    • DOI

      10.1093/nar/gkt049

    • Related Report
      2013 Annual Research Report 2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] patiotemporal regulation of meiotic recombination by Liaisonin.2013

    • Author(s)
      三好知一郎ら
    • Journal Title

      Bioarchitecture

      Volume: 3 Issue: 1 Pages: 20-24

    • DOI

      10.4161/bioa.23966

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Yeast hypertrophy: cause or consequence of aging? Reply to Bilinski et al2012

    • Author(s)
      Ganley AR, Breitenbach M, Kennedy BK, Kobayashi T.
    • Journal Title

      FEMS Yeast Res

      Volume: 12 Issue: 3 Pages: 267-268

    • DOI

      10.1111/j.1567-1364.2012.00796.x

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] A positive role for yeast extrachromosomal rDNA circles?2012

    • Author(s)
      Poole AM, Kobayashi T, Ganley AR.
    • Journal Title

      Bioessays

      Volume: 34 Issue: 9 Pages: 725-729

    • DOI

      10.1002/bies.201200037

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] A central coupler for recombination initiation linking chromosome architecture to S phase checkpoint.2012

    • Author(s)
      三好知一郎
    • Journal Title

      Molecular Cell

      Volume: 14 Issue: 5 Pages: 722-733

    • DOI

      10.1016/j.molcel.2012.06.023

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] A novel RNAi protein, Dsh1, assembles RNAi machinery on chromatin to amplify heterochromatic siRNA2012

    • Author(s)
      Kawakami K, Hayashi A, Nakayama J, & Murakami Y
    • Journal Title

      Genes Dev

      Volume: 26 Issue: 16 Pages: 811-1824

    • DOI

      10.1101/gad.190272.112

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Intrinsic Nucleic Acid-Binding activity of Chp1 Chromodomain Is Required for Heterochromatic Gene Silencing2012

    • Author(s)
      Ishida M, Shimojo H, Hayashi A, Kawaguchi R, Ohtani Y, Uegaki K, Nishimura Y, Nakayama J
    • Journal Title

      Mol Cell

      Volume: 47 Issue: 2 Pages: 228-241

    • DOI

      10.1016/j.molcel.2012.05.017

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Two different RFC proteins, Ctf18 and RFC1 separately control PCNA-CRL4Cdt2-mediated Cdt1 proteolysis during S phase and following UV-irradiation2012

    • Author(s)
      Shiomi Y, Ishii T, Hayashi A, Shinmyozu K, Nakayama J, Sugasawa K, & Nishitani H
    • Journal Title

      Mol Cell Biol

      Volume: 32 Issue: 12 Pages: 2279-88

    • DOI

      10.1128/mcb.06506-11

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Heterochromatin protein 1 homologue Swi6 acts in concert with Ers1 to regulate RNAi-directed heterochromatin assembly2012

    • Author(s)
      Hayashi, A., Ishida, M., Kawaguchi, R., Urano, T., Murakami, Y., Nakayama, J-I.
    • Journal Title

      Proc. Natl. Acad. Sci. USA

      Volume: (印刷中) Issue: 16 Pages: 6159-64

    • DOI

      10.1073/pnas.1116972109

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Endogenous DNA replication stress results in expansion of dNTP pools and a mutator phenotype2012

    • Author(s)
      Davidson MB, Katou Y, Keszthelyi A, Sing TL, Xia T, Ou J, Vaisica JA, Thevakumaran N, Marjavaara L, Myers CL, Chabes A, Shirahige K, Brown GW
    • Journal Title

      EMBO J.

      Volume: 31(4) Issue: 4 Pages: 895-907

    • DOI

      10.1038/emboj.2011.485

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] RNA and epigenetic silencing : Insight from fission yeast2012

    • Author(s)
      Derek Goto
    • Journal Title

      Development, Growth & Differentiation

      Volume: 54 Issue: 1 Pages: 129-141

    • DOI

      10.1111/j.1440-169x.2011.01310.x

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] How does genome instability affect lifespan?: roles of rDNA and telomeres.2011

    • Author(s)
      Kobayashi T.
    • Journal Title

      Genes Cells.

      Volume: 16 Issue: 6 Pages: 617-624

    • DOI

      10.1111/j.1365-2443.2011.01519.x

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Visualization of the dynamic behavior of ribosomal RNA gene repeats in living yeast cells2011

    • Author(s)
      Miyazaki T, Kobayashi T.
    • Journal Title

      Genes Cells

      Volume: 16 Issue: 5 Pages: 491-502

    • DOI

      10.1111/j.1365-2443.2011.01506.x

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Regulation of ribosomal RNA gene copy number and its role in modulating genome integrity and evolutionary adaptability in yeast2011

    • Author(s)
      Kobayashi T.
    • Journal Title

      Cell Mol Life Sci.

      Volume: 68 Issue: 8 Pages: 1395-1403

    • DOI

      10.1007/s00018-010-0613-2

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Replisome stability at defective DNA replication forks is independent of S phase checkpoint kinases2011

    • Author(s)
      De Piccoli G, Katou Y, Itoh T, Nakato R, Shirahige K, Labib K
    • Journal Title

      Mol Cell.

      Volume: 45 Issue: 5 Pages: 696-704

    • DOI

      10.1016/j.molcel.2012.01.007

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Origin association of Sld3, Sld7, and Cdc45 proteins is a key step for determination of origin-firing timing2011

    • Author(s)
      Tanaka, S., Nakano, R., Katou, Y., Shirahige, K. and Araki, H.
    • Journal Title

      Curr. Biol

      Volume: 21 Issue: 24 Pages: 2055-2063

    • DOI

      10.1016/j.cub.2011.11.038

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] The replication checkpoint protects fork stability by releasing trans cribed genes from nuclear pores2011

    • Author(s)
      Bermejo R, Capra T, Jossen R, Colosio A, Frattini C, Carotenuto W, Cocito A, Doksani Y, Klein H, Gomez-Gonzalez B, Aguilera A, Katou Y, Shirahige K, Foiani M
    • Journal Title

      Cell

      Volume: 146 Issue: 2 Pages: 233-246

    • DOI

      10.1016/j.cell.2011.06.033

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Fub1p, a novel protein isolated by boundary screening, binds the proteasome complex2011

    • Author(s)
      Hatanaka A, Chen B, Sun J-Q, Mano Y, Funakoshi M, Kobayashi H, Ju Y, Mizutani T, Shimyozu K, Nakayama J, Miyamoto K, Uchida H, Oki M
    • Journal Title

      Genes & Genetic Systems

      Volume: 86 Issue: 5 Pages: 305-314

    • DOI

      10.1266/ggs.86.305

    • NAID

      10030209843

    • ISSN
      1341-7568, 1880-5779
    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Presentation] ヘテロクロマチン構造形成におけるCLRC複合体の役割2016

    • Author(s)
      中山潤一
    • Organizer
      第33回染色体ワークショップ・第14回核ダイナミクス研究会 合同大会
    • Place of Presentation
      松島一の坊(宮城県宮城郡松島町)
    • Year and Date
      2016-01-13
    • Related Report
      2015 Annual Research Report
  • [Presentation] グルコース飢餓ストレス時のセンス・アンチセンス長鎖非コードRNAを介した遺伝子発現制御2015

    • Author(s)
      小田有沙 太田邦史
    • Organizer
      BMB2015
    • Place of Presentation
      ポートピアホテル(兵庫県神戸市)
    • Year and Date
      2015-12-02
    • Related Report
      2015 Annual Research Report
  • [Presentation] rDNA stability determines the faye of cell2015

    • Author(s)
      Kobayashi T
    • Organizer
      国際シンポジウムMolecular Biology of Ageing
    • Place of Presentation
      オランダ、フローリンゲン
    • Year and Date
      2015-10-25
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] More than 10 % of yeast genes are related to genome stability and influence cellular senescence via rDNA maintenance.2015

    • Author(s)
      Kobayashi T
    • Organizer
      国際シンポジウムNon-coding DNA and Chromosomal Integrity
    • Place of Presentation
      淡路夢舞台国際会議場(兵庫県淡路市)
    • Year and Date
      2015-08-07
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Crosstalk between histone modifications during heterochromatin assembly.2015

    • Author(s)
      Nakayama J.
    • Organizer
      第8回分裂酵母国際学会
    • Place of Presentation
      生田神社会館(兵庫県神戸市)
    • Year and Date
      2015-06-22
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Long noncoding RNAs stimulate promoter binding of the transcription factor Atf1 by antagonizing the Grougho/Tup1-like corepressors Tup11 and Tup122015

    • Author(s)
      Takemata N, Ohta K
    • Organizer
      Pombe2015
    • Place of Presentation
      生田神社会館(兵庫県神戸市)
    • Year and Date
      2015-06-21
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research
  • [Presentation] HP1における分裂期特異的リン酸化の動的制御とその機能2014

    • Author(s)
      西淵剛平、中山潤一
    • Organizer
      第32回染色体ワークショップ、第13回核ダイナミクス研究会
    • Place of Presentation
      広島市、安芸グランドホテル
    • Year and Date
      2014-12-16
    • Related Report
      2014 Annual Research Report
  • [Presentation] Stability of ribosomal RNA gene cluster and cellular senescence2014

    • Author(s)
      小林武彦
    • Organizer
      Vienna Biocenter seminar
    • Place of Presentation
      オーストリア、ウイーン
    • Year and Date
      2014-12-04 – 2014-12-06
    • Related Report
      2014 Annual Research Report
    • Invited
  • [Presentation] Instability of repetitive sequence and cellular senescence2014

    • Author(s)
      小林武彦
    • Organizer
      日本分子生物学会シンポジウム
    • Place of Presentation
      横浜、パシフィコ横浜
    • Year and Date
      2014-11-25 – 2014-11-27
    • Related Report
      2014 Annual Research Report
    • Invited
  • [Presentation] ゲノムの安定性と細胞老化2014

    • Author(s)
      小林武彦
    • Organizer
      第87回 日本生化学会大会
    • Place of Presentation
      京都、京都国際会議場
    • Year and Date
      2014-10-18
    • Related Report
      2014 Annual Research Report
    • Invited
  • [Presentation] HP1のリン酸化はH3K9me3 nucleosomeに対する結合特異性を制御している2014

    • Author(s)
      西淵剛平、町田晋一、越阪部晃永、村越大夢、濱田京子、中川れい子、Wolfgang Fischle、胡桃坂仁志、田上英明、中山潤一
    • Organizer
      第87回 日本生化学会大会
    • Place of Presentation
      京都市、京都国際会議場
    • Year and Date
      2014-10-16
    • Related Report
      2014 Annual Research Report
  • [Presentation] rDNA Instability and Cellular Senescence2014

    • Author(s)
      小林武彦
    • Organizer
      Gordon research conference
    • Place of Presentation
      香港、香港科学技術大学
    • Year and Date
      2014-07-06 – 2014-07-11
    • Related Report
      2014 Annual Research Report
    • Invited
  • [Presentation] Meiotic DSB Cold Spots in Yeast Chromosomal Axes2014

    • Author(s)
      太田邦史
    • Organizer
      2014 Meiosis Gordon Research Conference
    • Place of Presentation
      米国、ニューハンプシャー州
    • Year and Date
      2014-06-01 – 2014-06-06
    • Related Report
      2014 Annual Research Report
    • Invited
  • [Presentation] Role of Heterochromatin Protein 1 in higher-order chromatin assembly2014

    • Author(s)
      Jun-ichi Nakayama
    • Organizer
      IIAS Research Conference 2014 Chromatin Decoding
    • Place of Presentation
      木津川市、国際高等研究所
    • Year and Date
      2014-05-14
    • Related Report
      2014 Annual Research Report
    • Invited
  • [Presentation] Epigenetics and dynamics of non-coding genome2014

    • Author(s)
      太田邦史
    • Organizer
      高等研カンファレンス2014
    • Place of Presentation
      京都府木津川市、国際高等研究所
    • Year and Date
      2014-05-12 – 2014-05-15
    • Related Report
      2014 Annual Research Report
    • Invited
  • [Presentation] 栄養代謝・環境要素のエピゲノムへの影響2014

    • Author(s)
      太田邦史
    • Organizer
      第87回日本内分泌学会学術総会
    • Place of Presentation
      福岡市
    • Year and Date
      2014-04-24 – 2014-04-25
    • Related Report
      2014 Annual Research Report
    • Invited
  • [Presentation] Noncoding transcription regulates senescence in yeast2013

    • Author(s)
      Kobayashi T
    • Organizer
      国際シンポジウム"Evolution of non-coding DNA"
    • Place of Presentation
      神奈川県葉山町
    • Related Report
      2013 Annual Research Report
    • Invited
  • [Presentation] いきものの寿命-ヒトは何才まで生きられるのか2013

    • Author(s)
      小林武彦
    • Organizer
      三島市市民公開講座・遺伝学普及会連携事業
    • Place of Presentation
      静岡県三島市
    • Related Report
      2013 Annual Research Report
    • Invited
  • [Presentation] Spatio-temporal control of meiotic recombination initiation2013

    • Author(s)
      太田邦史
    • Organizer
      EMBO conference on fission yeast
    • Place of Presentation
      英国、ロンドン
    • Related Report
      2013 Annual Research Report
    • Invited
  • [Presentation] Determinants of meiotic recombination hotspot in S. pombe2013

    • Author(s)
      太田邦史
    • Organizer
      EMBO conference on meiosis
    • Place of Presentation
      ドイツ、ドレスデン
    • Related Report
      2013 Annual Research Report
    • Invited
  • [Presentation] Roles of chromodomain proteins in higher-order chromatin assembly2013

    • Author(s)
      中山潤一
    • Organizer
      エピジェネティクス国際シンポジウム
    • Place of Presentation
      福井県あわら市
    • Related Report
      2013 Annual Research Report
    • Invited
  • [Presentation] ヘテロクロマチンタンパク質HP1による高次クロマチン構造形成のメカニズム2013

    • Author(s)
      中山潤一
    • Organizer
      第86回 日本生化学会大会
    • Place of Presentation
      神奈川県横浜市
    • Related Report
      2013 Annual Research Report
    • Invited
  • [Presentation] rDNA instability and cellular senescence2012

    • Author(s)
      Kobayashi, Takehiko
    • Organizer
      The 8th 3R Symposium
    • Place of Presentation
      Awaji, Japan
    • Year and Date
      2012-11-25
    • Related Report
      2012 Annual Research Report
    • Invited
  • [Presentation] A novel mediator for meiotic recombination initiation that links chromosome architecture to S- phase checkpoint2012

    • Author(s)
      太田邦史
    • Organizer
      The 8th 3R Symposium
    • Place of Presentation
      Awaji, Japan
    • Year and Date
      2012-11-25
    • Related Report
      2012 Annual Research Report
    • Invited
  • [Presentation] A novel mediator for meiotic recombination initiation links chromosome architecture to S- phase checkpoint2012

    • Author(s)
      太田邦史
    • Organizer
      The 2012 CSHL Meeting on Dynamic Organization of Nuclear Function
    • Place of Presentation
      NY, USA
    • Year and Date
      2012-09-27
    • Related Report
      2012 Annual Research Report
    • Invited
  • [Presentation] rDNA instability and cellular senescence.2012

    • Author(s)
      Kobayashi, Takehiko
    • Organizer
      FASEB Yeast,Chromosome Structure, Replication Segregation
    • Place of Presentation
      Steamboat, Colorado USA
    • Year and Date
      2012-07-15
    • Related Report
      2012 Annual Research Report
    • Invited
  • [Presentation] ADLibシステムを用いたシーズ抗体の開発2012

    • Author(s)
      太田邦史
    • Organizer
      第12回日本蛋白質化学
    • Place of Presentation
      名古屋
    • Year and Date
      2012-06-20
    • Related Report
      2012 Annual Research Report
    • Invited
  • [Presentation] rDNA recombination and cellular senescence.2012

    • Author(s)
      Kobayashi, Takehiko
    • Organizer
      Embo Workshop Recombination Mechanisms and Genome Instability
    • Place of Presentation
      Jerez de la Frontera, Spain
    • Year and Date
      2012-05-21
    • Related Report
      2012 Annual Research Report
    • Invited
  • [Presentation] Conditional induction of whole genome remodeling in plants and fungi2012

    • Author(s)
      太田邦史
    • Organizer
      EMBO Genetic Stability and Change Workshop(
    • Place of Presentation
      フランス
    • Year and Date
      2012-05-02
    • Related Report
      2012 Annual Research Report
    • Invited
  • [Presentation] リボソームRNA遺伝子と細胞老化2012

    • Author(s)
      Takehiko Kobayashi
    • Organizer
      日本農芸化学会
    • Place of Presentation
      京都市(招待講演)
    • Year and Date
      2012-03-25
    • Related Report
      2011 Annual Research Report
  • [Presentation] rDNAの安定性と細胞老化2012

    • Author(s)
      小林武彦
    • Organizer
      リボソーム研究会
    • Place of Presentation
      東広島市
    • Year and Date
      2012-03-15
    • Related Report
      2011 Annual Research Report
  • [Presentation] RTT109はrDNAの異常増幅を防ぐ2012

    • Author(s)
      小林武彦
    • Organizer
      染色体ワークショップ
    • Place of Presentation
      宮城県
    • Year and Date
      2012-01-26
    • Related Report
      2011 Annual Research Report
  • [Presentation] 分裂酵母ヘテロクロマチン形成におけるChp1の役割2012

    • Author(s)
      中山潤一
    • Organizer
      第29回染色体ワークショップ
    • Place of Presentation
      仙台市
    • Year and Date
      2012-01-26
    • Related Report
      2011 Annual Research Report
  • [Presentation] rDNA instability and cellular senescence.2012

    • Author(s)
      Kobayashi, Takehiko
    • Organizer
      The 34th Japan Society for Biomedical Gerontology Symposium Micro-Nano Global COE
    • Place of Presentation
      Nagoya Japan
    • Related Report
      2012 Annual Research Report
    • Invited
  • [Presentation] いきものの寿命―ヒトは何歳まで生きられるか―2012

    • Author(s)
      小林武彦
    • Organizer
      第12回学習院大学生命科学シンポジウム
    • Place of Presentation
      東京、目白
    • Related Report
      2012 Annual Research Report
    • Invited
  • [Presentation] 分裂酵母の遺伝子サイレンシングにおけるクロモドメインタンパク質の役割2012

    • Author(s)
      中山 潤一
    • Organizer
      第35回日本分子生物学会年会
    • Place of Presentation
      福岡
    • Related Report
      2012 Annual Research Report
    • Invited
  • [Presentation] TAQingシステムを用いた酵母の大規模ゲノム改変2012

    • Author(s)
      太田邦史
    • Organizer
      第183回酵母細胞研究会例
    • Place of Presentation
      東京
    • Related Report
      2012 Annual Research Report
    • Invited
  • [Presentation] Gene regulation by lncRNAs in response to low glucose stress2011

    • Author(s)
      太田邦史, ら
    • Organizer
      分子生物学会
    • Place of Presentation
      神奈川、パシフィコ横浜
    • Year and Date
      2011-12-16
    • Related Report
      2011 Annual Research Report
  • [Presentation] Recovery of rDNA stability contributes to rejuvenation in yeast2011

    • Author(s)
      小林武彦
    • Organizer
      分子生物学会シンポジウム
    • Place of Presentation
      横浜市(招待講演)
    • Year and Date
      2011-12-15
    • Related Report
      2011 Annual Research Report
  • [Presentation] Roles of chromodomain proteins in higher-order chromatin assembly2011

    • Author(s)
      中山潤一
    • Organizer
      第34回日本分子生物学会年会
    • Place of Presentation
      横浜市(招待講演)
    • Year and Date
      2011-12-15
    • Related Report
      2011 Annual Research Report
  • [Presentation] 部位特異的なアセチル化を含む『エピヌクレオソーム』の試験管内再構成2011

    • Author(s)
      梅原崇史
    • Organizer
      第34回日本分子生物学会年会
    • Place of Presentation
      横浜市
    • Year and Date
      2011-12-15
    • Related Report
      2011 Annual Research Report
  • [Presentation] 高次クロマチン構造の形成と維持の分子機構2011

    • Author(s)
      中山潤一
    • Organizer
      第62回染色体学会年会
    • Place of Presentation
      横浜市(招待講演)
    • Year and Date
      2011-11-12
    • Related Report
      2011 Annual Research Report
  • [Presentation] Maintenance of the ribosomal RNA gene repeat and its role in cellular senescence2011

    • Author(s)
      Takehiko Kobayashi
    • Organizer
      The 5th International Workshop on Cell Regulations in Division and Arrest
    • Place of Presentation
      OIST, Okinawa(招待講演)
    • Year and Date
      2011-10-24
    • Related Report
      2011 Annual Research Report
  • [Presentation] Rec15Mer2 bridges meiotic recombination initiation sites to chromosome axes to facilitate the assembly of recombination initiation complexes2011

    • Author(s)
      太田邦史, ら
    • Organizer
      EMBO workshop (Meiosis)
    • Place of Presentation
      イタリア、Paestum
    • Year and Date
      2011-09-19
    • Related Report
      2011 Annual Research Report
  • [Presentation] ヒストン修飾とリボソームRNA遺伝子のコピー数制御2011

    • Author(s)
      小林武彦
    • Organizer
      酵母遺伝学フォーラム
    • Place of Presentation
      福岡市
    • Year and Date
      2011-09-06
    • Related Report
      2011 Annual Research Report
  • [Presentation] Role of long non-coding RNAs during glucose starvation in fission yeast2011

    • Author(s)
      竹俣直道, ら
    • Organizer
      FASEB Summer Conferences (epigenetics)
    • Place of Presentation
      アメリカ、Snowmass
    • Year and Date
      2011-08-03
    • Related Report
      2011 Annual Research Report
  • [Presentation] 環境応答とエピゲノム2011

    • Author(s)
      太田邦史
    • Organizer
      第25回環境ホルモン学会
    • Place of Presentation
      東京、東大(本郷)(招待講演)
    • Year and Date
      2011-06-16
    • Related Report
      2011 Annual Research Report
  • [Presentation] 大規模ゲノム再編成システム2011

    • Author(s)
      太田邦史
    • Organizer
      第7回よこはまバイオマス研究会
    • Place of Presentation
      神奈川、横浜市立大(招待講演)
    • Year and Date
      2011-05-31
    • Related Report
      2011 Annual Research Report
  • [Presentation] Regulation of ribosomal RNA gene copy number and its role in modulating genome integrity and evolutionary adaptability in yeast2011

    • Author(s)
      Takehiko Kobayashi
    • Organizer
      OIST Workshop (QECG2011) : Linkage and Recombination in Genome sequences
    • Place of Presentation
      OIST, Okinawa(招待講演)
    • Year and Date
      2011-05-25
    • Related Report
      2011 Annual Research Report
  • [Book] 岩波ジュニア新書「寿命はなぜ決まっているのかー長生き遺伝子のヒミツー」2016

    • Author(s)
      小林武彦
    • Total Pages
      240
    • Publisher
      岩波書店
    • Related Report
      2015 Annual Research Report
  • [Book] 岩波ジュニア新書「生命デザイン学入門」2016

    • Author(s)
      小川(西秋)葉子、太田邦史
    • Total Pages
      224
    • Publisher
      岩波書店
    • Related Report
      2015 Annual Research Report
  • [Book] ゲノムを司るインターメア:非コードDNAの新たな展開2015

    • Author(s)
      小林武彦 編
    • Total Pages
      248
    • Publisher
      化学同人
    • Related Report
      2015 Annual Research Report
  • [Book] エピジェネティクス革命2015

    • Author(s)
      ネッサ・キャリー著 中山潤一訳
    • Total Pages
      428
    • Publisher
      丸善出版
    • Related Report
      2015 Annual Research Report
  • [Book] 遺伝子が語る生命38億年の謎―なぜ、ゾウはネズミより長生きか?2014

    • Author(s)
      小林武彦(共著)
    • Total Pages
      248
    • Publisher
      悠書館
    • Related Report
      2014 Annual Research Report
  • [Book] 遺伝子図鑑2013

    • Author(s)
      小林武彦
    • Total Pages
      272
    • Publisher
      悠書館
    • Related Report
      2013 Annual Research Report
  • [Book] 染色体と細胞核のダイナミクス2013

    • Author(s)
      中山潤一
    • Total Pages
      224
    • Publisher
      化学同人
    • Related Report
      2013 Annual Research Report
  • [Book] エピジェネティクス2013

    • Author(s)
      中山潤一
    • Total Pages
      282
    • Publisher
      化学同人
    • Related Report
      2013 Annual Research Report
  • [Book] エピゲノムと生命2013

    • Author(s)
      太田邦史
    • Total Pages
      280
    • Publisher
      講談社
    • Related Report
      2013 Annual Research Report
  • [Book] 進化分子工学2013

    • Author(s)
      黒澤恒平,橋本講司,瀬尾秀宗,太田邦史
    • Total Pages
      466
    • Publisher
      (株)エヌ・ティー・エス
    • Related Report
      2013 Annual Research Report
  • [Book] Chimeric antibodies” In “Human Monoclonal Antibodies: Methods and Protocols2013

    • Author(s)
      黒澤恒平
    • Publisher
      Springer
    • Related Report
      2012 Annual Research Report
  • [Book] 岩波 生物学辞典 第5版2012

    • Author(s)
      巌佐庸
    • Total Pages
      2171
    • Publisher
      岩波書店
    • Related Report
      2012 Annual Research Report
  • [Book] 実験医学別冊「核酸実験の原理とプロトコール」2011

    • Author(s)
      小林武彦、坂季美子
    • Total Pages
      7
    • Publisher
      羊土社
    • Related Report
      2011 Annual Research Report
  • [Book] 生体の科学「細胞核」vol.622011

    • Author(s)
      小林武彦
    • Total Pages
      7
    • Publisher
      医学書院
    • Related Report
      2011 Annual Research Report
  • [Book] 実験医学v292011

    • Author(s)
      太田邦史、小田有沙, ら
    • Total Pages
      5
    • Publisher
      羊土社
    • Related Report
      2011 Annual Research Report
  • [Book] Endocrine Disrupter News Letter2011

    • Author(s)
      太田邦史
    • Total Pages
      1
    • Publisher
      環境ホルモン学会
    • Related Report
      2011 Annual Research Report
  • [Remarks] ゲノムを支える非コードDNA領域の機能

    • URL

      http://www.nsc.nagoya-cu.ac.jp/~jnakayam/ncDNA.html

    • Related Report
      2015 Annual Research Report 2014 Annual Research Report 2012 Annual Research Report
  • [Remarks] 小林研究室

    • URL

      http://lafula-com.info/kobayashiken/CytoGen/index.html

    • Related Report
      2015 Annual Research Report
  • [Remarks] 中山研究室

    • URL

      http://www.nsc.nagoya-cu.ac.jp/~jnakayam/ncDNA.html

    • Related Report
      2015 Annual Research Report
  • [Remarks] 太田研究室

    • URL

      http://www.ohta-lab.c.u-tokyo.ac.jp

    • Related Report
      2015 Annual Research Report
  • [Remarks] 小林研究室

    • URL

      http://lafula-com.info/kobayashiken/CytoGen/

    • Related Report
      2014 Annual Research Report
  • [Remarks] 中山研究室

    • URL

      http://www.nsc.nagoya-cu.ac.jp/~jnakayam/

    • Related Report
      2014 Annual Research Report
  • [Remarks] 太田研究室

    • URL

      http://www.ohta-lab.c.u-tokyo.ac.jp/

    • Related Report
      2014 Annual Research Report
  • [Remarks] 新学術領域「ゲノムを支える非コードDNA領域の機能」

    • URL

      http://www.nsc.nagoya-cu.ac.jp/~jnakayam/ncDNA.html

    • Related Report
      2013 Annual Research Report
  • [Remarks] 小林研究室

    • URL

      http://www.nig.ac.jp/labs/CytoGen/index.html

    • Related Report
      2013 Annual Research Report
  • [Remarks] 中山研究室

    • URL

      http://www.nsc.nagoya-cu.ac.jp/~jnakayam/

    • Related Report
      2013 Annual Research Report
  • [Remarks] 太田研究室

    • URL

      http://www.ohta-lab.c.u-tokyo.ac.jp/

    • Related Report
      2013 Annual Research Report
  • [Remarks] 小林研究室

    • URL

      http://www.nig.ac.jp/labs/CytoGen/index.html

    • Related Report
      2012 Annual Research Report
  • [Remarks] 東京大学大学院総合文化研究科太田研究室

    • Related Report
      2012 Annual Research Report
  • [Remarks] Nakayama lab

    • URL

      http://www.nsc.nagoya-cu.ac.jp/~jnakayam/

    • Related Report
      2012 Annual Research Report
  • [Remarks]

    • URL

      http://www.nig.ac.jp/labs/CytoGen/index.html

    • Related Report
      2011 Annual Research Report
  • [Remarks]

    • URL

      http://www.ohta-lab.c.u-tokyo.ac.jp/

    • Related Report
      2011 Annual Research Report
  • [Patent(Industrial Property Rights)] 空間的な近さの概念を用いた生体分子データの3次元構造の再構2016

    • Inventor(s)
      平田祥人、小田有沙、太田邦史、合原一幸
    • Industrial Property Rights Holder
      平田祥人、小田有沙、太田邦史、合原一幸
    • Industrial Property Rights Type
      特許
    • Industrial Property Number
      2016-023214
    • Filing Date
      2016-02-10
    • Related Report
      2015 Annual Research Report
  • [Patent(Industrial Property Rights)] 植物バイオマスの増産方法2013

    • Inventor(s)
      村本伸彦ら
    • Industrial Property Rights Holder
      豊田中央研究 所、東京大学
    • Industrial Property Rights Type
      特許
    • Industrial Property Number
      2013-049689
    • Filing Date
      2013-03-12
    • Related Report
      2012 Annual Research Report
  • [Patent(Industrial Property Rights)] 非誘導体型LPAに対して作製された抗LPA抗体2012

    • Inventor(s)
      太田邦史ら
    • Industrial Property Rights Holder
      東京大学
    • Industrial Property Rights Type
      特許
    • Industrial Property Number
      2012-284612
    • Filing Date
      2012-12-28
    • Related Report
      2012 Annual Research Report
  • [Patent(Industrial Property Rights)] タンパク質の迅速改良法2012

    • Inventor(s)
      黒澤恒平、太田 邦史、瀬尾秀宗
    • Industrial Property Rights Holder
      東京大学、カイオ ム・バイオサイエ ンス
    • Industrial Property Rights Type
      特許
    • Industrial Property Number
      2012-138293
    • Filing Date
      2012-06-20
    • Related Report
      2012 Annual Research Report
  • [Funded Workshop] Non-coding DNA and Chromosomal Integrity2015

    • Place of Presentation
      淡路夢舞台国際会議場(兵庫県淡路市)
    • Year and Date
      2015-08-07
    • Related Report
      2015 Annual Research Report

URL: 

Published: 2011-08-01   Modified: 2019-07-29  

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