| Project Area | "Matryoshka"-type evolution of eukaryotes |
|---|
| Project/Area Number |
23117001
|
|---|
| Research Category |
Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)
|
| Allocation Type | Single-year Grants |
|---|
| Review Section |
Biological Sciences
|
|---|
| Research Institution | National Institute of Infectious Diseases |
|---|
Principal Investigator |
|
|---|
| Co-Investigator(Kenkyū-buntansha) |
SUZAKI Toshinobu 神戸大学, 理学研究科, 准教授 (00187692)
TSUBOI Takafumi 愛媛大学, プロテオサイエンスセンター, 教授 (00188616)
MORIYA Shigeharu 国立研究開発法人理化学研究所, 主任研究員研究室等, 専任研究員 (00321828)
TSUKUI Kumiko 国立感染症研究所, 寄生動物部, 主任研究員 (00420092)
MATSUZAKI Motomichi 東京大学, 大学院医学系研究科(医学部), 助教 (00511396)
TACHIBANA Hiroshi 東海大学, 医学部, 教授 (10147168)
ISHIDA Kenichiro 筑波大学, 生命環境系, 教授 (30282198)
OBOKATA Junichi 京都府立大学, 生命環境科学研究科, 教授 (50185667)
HASHIMOTO Tetsuo 筑波大学, 生命環境系, 教授 (50208451)
KANEKO Osamu 長崎大学, 熱帯医学研究所, 教授 (50325370)
INAGAKI Yuji 筑波大学, 生命環境系, 准教授 (50387958)
INOUE Isao 筑波大学, 生命環境系, 教授 (70168433)
NAGAI Hiroki 大阪大学, 微生物病研究所, 准教授 (80222173)
KURODA Makoto 国立感染症研究所, 病原体ゲノム解析研究センター, センター長 (80317411)
NAGAMUNE Kisaburo 国立感染症研究所, 寄生動物部, 室長 (90314418)
|
|---|
| Project Period (FY) |
2011-04-01 – 2016-03-31
|
| Project Status |
Completed (Fiscal Year 2015)
|
| Budget Amount *help |
¥226,850,000 (Direct Cost: ¥174,500,000、Indirect Cost: ¥52,350,000)
Fiscal Year 2015: ¥28,600,000 (Direct Cost: ¥22,000,000、Indirect Cost: ¥6,600,000)
Fiscal Year 2014: ¥23,920,000 (Direct Cost: ¥18,400,000、Indirect Cost: ¥5,520,000)
Fiscal Year 2013: ¥30,160,000 (Direct Cost: ¥23,200,000、Indirect Cost: ¥6,960,000)
Fiscal Year 2012: ¥25,090,000 (Direct Cost: ¥19,300,000、Indirect Cost: ¥5,790,000)
Fiscal Year 2011: ¥119,080,000 (Direct Cost: ¥91,600,000、Indirect Cost: ¥27,480,000)
|
|---|
| Keywords | 進化 / 共生 / 寄生 / オルガネラ / ミトコンドリア / 葉緑体 / 内部共生 / 微生物 |
|---|
| Outline of Final Research Achievements |
Evolution of eukaryotes and organelles is one of the most fundamental topics of biology. Plastids and mitochondria are derived from endosymbiosis between bacteria and ancestral eukaryotes (most likely archeae), and gave significant metabolic advantages to eukaryotes. This study aimed at (1) identification of various primary and secondary (endo)symbiosis in nature and elucidation of shared fundamental mechanisms, (2) elucidation of physiological functions and mechanisms of quality control of such endosymbiosis-derived organelles, (3) establishment of a new paradigm of “endosymbiosis-driven evolution of eukaryotes”, which we named “Matryoshka-type evolution”, and (4) development of synthetic biological methods that allow artificial evolution of cell functions, such as addition of new metabolic functions to organelles and organelle manipulation/transfer.
|
