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Analysis and Synthesis of Multidimensional Immune Organ Network

Administrative Group

Project AreaAnalysis and synthesis of multi-dimensional immune organ network
Project/Area Number 24111001
Research Category

Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)

Allocation TypeSingle-year Grants
Review Section Biological Sciences
Research InstitutionThe University of Tokushima

Principal Investigator

TAKAHAMA Yousuke  徳島大学, 先端酵素学研究所, 教授 (20183858)

Co-Investigator(Kenkyū-buntansha) 渡邊 武  公益財団法人田附興風会, 医学研究所, 特任研究指導者 (40028684)
湊 長博  京都大学, 医学(系)研究科(研究院), 教授 (40137716)
宮坂 昌之  大阪大学, その他部局等, 名誉教授 (50064613)
高田 慎治  大学共同利用機関法人自然科学研究機構(岡崎共通研究施設), 基礎生物学研究所, 教授 (60206753)
福井 宣規  九州大学, 生体防御医学研究所, 教授 (60243961)
長澤 丘司  大阪大学, 生命機能研究科, 教授 (80281690)
高木 淳一  大阪大学, たんぱく質研究所, 教授 (90212000)
Project Period (FY) 2012-06-28 – 2017-03-31
Project Status Completed (Fiscal Year 2016)
Budget Amount *help
¥34,840,000 (Direct Cost: ¥26,800,000、Indirect Cost: ¥8,040,000)
Fiscal Year 2016: ¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2015: ¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2014: ¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2013: ¥9,360,000 (Direct Cost: ¥7,200,000、Indirect Cost: ¥2,160,000)
Fiscal Year 2012: ¥11,440,000 (Direct Cost: ¥8,800,000、Indirect Cost: ¥2,640,000)
Keywords免疫学 / ストローマ細胞 / 免疫の場 / リンパ器官 / 免疫空間
Outline of Final Research Achievements

The findings include that (1) Foxc1 is a critical regulator of haematopoietic stem cell niche formation, (2) medullary thymic epithelial stem cells maintain a functional thymus to ensure lifelong central T cell tolerance, (3) TCR affinity for thymoproteasome-dependent positively selecting peptides conditions antigen responsiveness in CD8+ T cells, and (4) fibroblastic reticular cell-derived lysophosphatidic acid regulates T-cell motility within the lymph nodes. It was also found that (5) the transcription factor EPAS1 links DOCK8 deficiency to atopic skin inflammation via IL-31 induction, (6) lysosomal sorting of amyloid-beta by the SORLA receptor is impaired by a familial Alzheimer’s disease mutation, (7) a CD153+CD4+ T follicular cell population with cell-senescence features plays a crucial role in lupus pathogenesis via osteopontin production, and (8) gel-trapped lymphorganogenic chemokines trigger artificial tertiary lymphoid organs and mount adaptive immune responses in vivo.

Report

(6 results)
  • 2016 Annual Research Report   Final Research Report ( PDF )
  • 2015 Annual Research Report
  • 2014 Annual Research Report
  • 2013 Annual Research Report
  • 2012 Annual Research Report
  • Research Products

    (284 results)

All 2017 2016 2015 2014 2013 2012 Other

All Int'l Joint Research (12 results) Journal Article (245 results) (of which Int'l Joint Research: 37 results,  Peer Reviewed: 245 results,  Open Access: 103 results,  Acknowledgement Compliant: 45 results) Presentation (18 results) (of which Int'l Joint Research: 11 results,  Invited: 12 results) Book (3 results) Remarks (3 results) Funded Workshop (3 results)

  • [Int'l Joint Research] National Institutes of Health/University of California(米国)

    • Related Report
      2016 Annual Research Report
  • [Int'l Joint Research] University of Oxford(英国)

    • Related Report
      2016 Annual Research Report
  • [Int'l Joint Research] University of Basel(スイス)

    • Related Report
      2016 Annual Research Report
  • [Int'l Joint Research] McGill University(カナダ)

    • Related Report
      2016 Annual Research Report
  • [Int'l Joint Research] Universite Montpellier/Claude Bernard University(フランス)

    • Related Report
      2016 Annual Research Report
  • [Int'l Joint Research]

    • Related Report
      2016 Annual Research Report
  • [Int'l Joint Research] National Institutes of Health/University of California(米国)

    • Related Report
      2015 Annual Research Report
  • [Int'l Joint Research] University of Oxford(英国)

    • Related Report
      2015 Annual Research Report
  • [Int'l Joint Research] University of Basel(スイス)

    • Related Report
      2015 Annual Research Report
  • [Int'l Joint Research] McGill University(カナダ)

    • Related Report
      2015 Annual Research Report
  • [Int'l Joint Research] Universite Montpellier/Claude Bernard University(フランス)

    • Related Report
      2015 Annual Research Report
  • [Int'l Joint Research]

    • Related Report
      2015 Annual Research Report
  • [Journal Article] IL4 from T follicular helper cells downregulates antitumor immunity.2017

    • Author(s)
      Shirota H, Klinman DM, Ito S, Ito H, Kubo M, Ishioka C.
    • Journal Title

      Cancer Immunol Res

      Volume: 5 Issue: 1 Pages: 61-71

    • DOI

      10.1158/2326-6066.cir-16-0113

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Allergen-induced CD4+ T-cell cytokine production within airway mucosal DC-T-cell clusters drives the local recruitment of myeloid effector cells.2017

    • Author(s)
      Veres TZ, Kopcsanyi T, van Panhuys N, Gerner MY, Liu Z, Rantakari P, Dunkel J, Miyasaka M, Salmi M, Jalkanen S, Germain RN.
    • Journal Title

      J Immunol

      Volume: 198 Issue: 2 Pages: 895-907

    • DOI

      10.4049/jimmunol.1601448

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] The transcription factor EPAS1 links DOCK8 deficiency to atopic skin inflammation via IL-31 induction.2017

    • Author(s)
      Yamamura K, Uruno T, Shiraishi A, Tanaka Y, Ushijima M, Nakahara T, Watanabe M, Kido-Nakahara M, Tsuge I, Furue M, Fukui Y.
    • Journal Title

      Nat Commun

      Volume: 8 Issue: 1 Pages: 13946-13946

    • DOI

      10.1038/ncomms13946

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Conformational freedom of the LRP6 ectodomain is regulated by N-glycosylation and the binding of the Wnt antagonist Dkk1.2017

    • Author(s)
      Matoba K, Mihara E, Tamura-Kawakami K, Miyazaki N, Maeda S, Hirai H, Thompson S, Iwasaki K, and Takagi J.
    • Journal Title

      Cell Rep

      Volume: 18 Issue: 1 Pages: 32-40

    • DOI

      10.1016/j.celrep.2016.12.017

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] Stromal Cell Subsets Directing Neonatal Spleen Regeneration.2017

    • Author(s)
      Tan JK, Watanabe T.
    • Journal Title

      Sci Rep

      Volume: 7 Issue: 1 Pages: 40401-40401

    • DOI

      10.1038/srep40401

    • NAID

      120005997788

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Anti-SIRPα antibodies as a potential new tool for cancer immunotherapy.2017

    • Author(s)
      Yanagita T, Murata Y, Tanaka D, Motegi S, Arai E, Daniwijaya EW, Hazama D, Washio K, Saito Y, Kotani T, Ohnishi H, Oldenborg PA, Verjan Garcia N, Miyasaka M, Ishikawa O, Kanai Y, Komori T, Matozaki T.
    • Journal Title

      JCI Insight

      Volume: 2 Issue: 1

    • DOI

      10.1172/jci.insight.89140

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Foxn1-β5t transcriptional axis controls CD8+ T cell production in the thymus.2017

    • Author(s)
      Uddin MM, Ohigashi I, Motosugi R, Nakayama T, Sakata M, Hamazaki J, Nishito Y, Rode I, Tanaka K, Takemoto T, Murata S, Takahama Y.
    • Journal Title

      Nat Commun

      Volume: 8 Issue: 1 Pages: 14419-14419

    • DOI

      10.1038/ncomms14419

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] DOCK8 Regulates Macrophage Migration through Cdc42 Activation and LRAP35a Interaction.2017

    • Author(s)
      Shiraishi A, Uruno T, Sanematsu F, Ushijima M, Sakata D, Hara T, Fukui Y.
    • Journal Title

      J Biol Chem

      Volume: 292 Issue: 6 Pages: 2191-2202

    • DOI

      10.1074/jbc.m116.736306

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] Amine oxidase activity regulates the development of pulmonary fibrosis.2017

    • Author(s)
      Marttila-Ichihara F, Elima K, Auvinen K, Veres TZ, Rantakari P, Weston C, Miyasaka M, Adams D, Jalkanen S, Salmi M.
    • Journal Title

      FASEB J

      Volume: 印刷中 Issue: 6 Pages: 2477-2491

    • DOI

      10.1096/fj.201600935r

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Generation of diversity in thymic epithelial cells.2017

    • Author(s)
      Takahama Y, Ohigashi I, Baik S, Anderson G.
    • Journal Title

      Nat Rev Immunol

      Volume: 印刷中 Issue: 5 Pages: 295-305

    • DOI

      10.1038/nri.2017.12

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] Generation of peptides that promote positive selection in the thymus.2017

    • Author(s)
      Takada K, Kondo K, Takahama Y.
    • Journal Title

      J Immunol

      Volume: 198 Issue: 6 Pages: 2215-2222

    • DOI

      10.4049/jimmunol.1601862

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Intubation-free in vivo imaging of the tracheal mucosa using two photon microscopy.2017

    • Author(s)
      Veres TZ, Kopcsanyi T, Tirri M, Braun A, Miyasaka M, Germain RN, Jalkanen S, Salmi M.
    • Journal Title

      Sci Rep

      Volume: 印刷中 Issue: 1 Pages: 694-694

    • DOI

      10.1038/s41598-017-00769-6

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Involvement of activation-induced cytidine deaminase in skin cancer development.2016

    • Author(s)
      Nonaka, T., Toda, Y., Hiai, H., Uemura, M., Nakamura, M., Yamamoto, N., Asato, R., Hattori, Y., Bessho, K., Minato, N., Kinoshita, K.
    • Journal Title

      J. Clini. Invest.

      Volume: 126 Issue: 4 Pages: 1367-1382

    • DOI

      10.1172/jci81522

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Relb acts downstream of medullary thymic epithelial stem cells and is essential for the emergence of RANK+ medullary epithelial progenitors.2016

    • Author(s)
      Baik S, Sekai M, Hamazaki Y, Jenkinson WE, Anderson G.
    • Journal Title

      Eur J Immunol.

      Volume: - Issue: 4 Pages: 857-62

    • DOI

      10.1002/eji.201546253

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] Aberrant PD-L1 expression via 3’-UTR disruption in multiple cancers.2016

    • Author(s)
      K.Kataoka, (27名) N. Minato, K.Kashiwase, K. Izutsu, A. Takaori-Kondo, Y. Miyazaki, S. Takahashi, T. Shibata, H. Kawamoto, Y. Akatsuka, K. Shimoda, K. Takeuchi, T. Seya, S. Miyano, S. Ogawa.
    • Journal Title

      Nature

      Volume: 534 Issue: 7607 Pages: 402-406

    • DOI

      10.1038/nature18294

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] MEIS1-mediated transactivation of synaptotagmin-like 1 promotes CXCL12/CXCR4 signaling and leukemogenesis.2016

    • Author(s)
      Yokoyama T, Nakatake M, Kuwata T, Couiznet A, Goitsuka R, Tsutsumi S, Aburatani H, Valk PJ, Delwel R, Nakamura T.
    • Journal Title

      J Clin Invest.

      Volume: 印刷中 Issue: 5 Pages: 1664-1678

    • DOI

      10.1172/jci81516

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Thy-1+IL-7+ lymphatic endothelial cells in iBALT provide a survival niche for memory T-helper cells in allergic airway inflammation2016

    • Author(s)
      Shinoda, K., Hirahara, K., Iinuma, T., Ichikawa, T., Suzuki, A. S., Sugaya, K., Tumes, D. J., Yamamoto, H., Hara, T., Tani-ichi, S., Ikuta, K., Okamoto, Y., and Nakayama, T.
    • Journal Title

      Proc. Natl. Acad. Sci. USA.

      Volume: 113 Issue: 20

    • DOI

      10.1073/pnas.1512600113

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Parallel Regulation of von Hippel-Lindau Disease by pVHL-Mediated Degradation of B-Myb and Hypoxia-Inducible Factor α.2016

    • Author(s)
      Okumura F, Uematsu K, Byrne SD, Hirano M, Joo-Okumura A, Nishikimi A, Shuin T, Fukui Y, Nakatsukasa K, Kamura T.
    • Journal Title

      Molecular Cellular Biology

      Volume: 36 Issue: 12 Pages: 1803-1817

    • DOI

      10.1128/mcb.00067-16

    • NAID

      120005844088

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Medullary thymic epithelial stem cells: role in thymic epithelial cell maintenance and thymic involution2016

    • Author(s)
      Hamazaki Y, Sekai M, Minato N
    • Journal Title

      Immunol Rev.

      Volume: 271 Issue: 1 Pages: 38-55

    • DOI

      10.1111/imr.12412

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] Development and developmental potential of cortical thymic epithelial cells.2016

    • Author(s)
      Ohigashi I, Kozai M, Takahama Y.
    • Journal Title

      Immunol Rev

      Volume: 271 Issue: 1 Pages: 10-22

    • DOI

      10.1111/imr.12404

    • NAID

      120006727049

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Microenvironmental control of high-speed interstitial T cell migration in the lymph node.2016

    • Author(s)
      Katakai T, Kinashi T.
    • Journal Title

      Front Immunol

      Volume: 7 Pages: 194-194

    • DOI

      10.3389/fimmu.2016.00194

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Sepsis-induced osteoblast ablation causes immunodeficiency2016

    • Author(s)
      Terashima, A., Okamoto, K., Nakashima, T., Akira, S., Ikuta, K. and Takayanagi, H.
    • Journal Title

      Immunity

      Volume: 44 Issue: 6 Pages: 1434-1443

    • DOI

      10.1016/j.immuni.2016.05.012

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Hyperactivation of JAK1 tyrosine kinase induces stepwise, progressive pruritic dermatitis2016

    • Author(s)
      Yasuda T, Fukada T, Nishida K, Nakayama M, Matsuda M, Miura I, Dainichi T, Fukuda S, Kabashima K, Nakaoka S, Bin BH, Kubo M, Ohno H, Hasegawa T, Ohara O, Koseki H, Wakana S, Yoshida H
    • Journal Title

      J. Clin. Invest

      Volume: 126(6) Issue: 6 Pages: 2064-76

    • DOI

      10.1172/jci82887

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] DOCK2 confers immunity and intestinal colonization resistance to Citrobacter rodentium infection.2016

    • Author(s)
      Liu Z, Man SM, Zhu Q, Vogel P, Frase S, Fukui Y, Kanneganti TD.
    • Journal Title

      Sci Rep

      Volume: 6 Issue: 1 Pages: 27814-27814

    • DOI

      10.1038/srep27814

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Structure of the plexin ectodomain bound by semaphorin-mimicking antibodies.2016

    • Author(s)
      Suzuki K, Tsunoda H, Omiya R, Matoba K, Baba T, Suzuki S, Segawa H, Kumanogoh A, Iwasaki K, Hattori K, Takagi J.
    • Journal Title

      PLoS One

      Volume: 11 Issue: 6 Pages: e0156719-e0156719

    • DOI

      10.1371/journal.pone.0156719

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Identification of embryonic precursor cells that differentiate into thymic epithelial cells expressing autoimmune regulator.2016

    • Author(s)
      Akiyama N, Takizawa N, Miyauchi M, Yanai H, Tateishi R, Shinzawa M, Yoshinaga R, Kurihara M, Demizu Y, Yasuda H, Yagi S, Wu G, Matsumoto M, Sakamoto R, Yoshida N, Penninger JM, Kobayashi Y, Inoue J, Akiyama T.
    • Journal Title

      The Journal of Experimental Medicine

      Volume: 213 Issue: 8 Pages: 1441-1458

    • DOI

      10.1084/jem.20151780

    • NAID

      120006532434

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] Heterogeneous fibroblasts underlie age-dependent tertiary lymphoid tissues in the kidney2016

    • Author(s)
      Sato Y, Mii A, Hamazaki Y, Fujita H, Nakata H, Masuda K, Nishiyama S, Shibuya S, Haga H, Ogawa O, Shimizu A, Narumiya S, Kaisho T, Arita M, Yanagisawa M, Miyasaka M, Sharma K, Minato N, Kawamoto H, and Yanagita M.
    • Journal Title

      JCI. Insight.

      Volume: 1 Issue: 11

    • DOI

      10.1172/jci.insight.87680

    • NAID

      120005820865

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] Gel-trapped lymphorganogenic chemokines trigger artificial tertiary lymphoid organs and mount adaptive immune responses in vivo.2016

    • Author(s)
      Kobayashi Y, Watanabe T.
    • Journal Title

      Front Immunol

      Volume: 7 Pages: 316-316

    • DOI

      10.3389/fimmu.2016.00316

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Gene expression profiling of different arms of lymphatic vasculature identifies new candidates for manipulation of cell traffic.2016

    • Author(s)
      Iftakhar-E-Khuda I, Fair-Makela R, Kukkonen-Macchi A, Elima K, Karikoski M, Rantakari P, Miyasaka M, Salmi M, Jalkanen S.
    • Journal Title

      Proc Natl Acad Sci USA

      Volume: 113 Issue: 38 Pages: 10643-10648

    • DOI

      10.1073/pnas.1602357113

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Probing conformational and functional states of human hepatocyte growth factor by a panel of monoclonal antibodies.2016

    • Author(s)
      Umitsu M, Sakai K, Ogasawara S, Kaneko M, Asaki R, Tamura-Kawakami K, Kato Y, Matsumoto K, Takagi J.
    • Journal Title

      Sci Rep

      Volume: 9 Issue: 1 Pages: 33149-33149

    • DOI

      10.1038/srep33149

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Mice Deficient in Angiopoietin-like Protein 2 (Angptl2) Gene Show Increased Susceptibility to Bacterial Infection Due to Attenuated Macrophage Activity2016

    • Author(s)
      Yugami M, Odagiri H, Endo M, Tsutsuki H, Fujii S, Kadomatsu T, Masuda T, Miyata K, Terada K, Tanoue H, Ito H, Morinaga J, Horiguchi H, Sugizaki T, Akaike T, Gotoh T, Takai T, Sawa T, Mizuta H, Oike Y
    • Journal Title

      Journal of Biological Chemistry

      Volume: 291 Issue: 36 Pages: 18843-18852

    • DOI

      10.1074/jbc.m116.720870

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Structural basis for multi-specific peptide recognition by the anti-IDH1/2 monoclonal antibody, MsMab-1.2016

    • Author(s)
      Kitago Y, Kaneko MK, Ogasawara S, Kato Y, Takagi J.
    • Journal Title

      Biochem Biophys Res Commun

      Volume: 478 Issue: 3 Pages: 1274-1279

    • DOI

      10.1016/j.bbrc.2016.08.110

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Protective neutralizing influenza antibody response in the absence of T follicular helper cells2016

    • Author(s)
      Miyauchi K, Sugimoto-Ishige A, Harada Y, Adachi Y, Usami Y, Kaji T, Inoue K, Hasegawa H, Watanabe T, Hijikata A, Fukuyama S, Maemura T, Okada-Hatakeyama M, Ohara O, Kawaoka Y, Takahashi Y, Takemori T, Kubo M
    • Journal Title

      Nature Immunology

      Volume: 17(12) Issue: 12 Pages: 1447-1458

    • DOI

      10.1038/ni.3563

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Fibroblastic reticular cells regulate intestinal inflammation through IL-15-mediated control of group 1 ILCs2016

    • Author(s)
      Gil-Cruz, C., Perez-Shibayama, C., Onder, L., Chai, Q., Cupovic, J., Cheng, H., Novkovic, M., Lang, P. A., Geuking, M. B., McCoy, K. D., Abe, S., Cui, G., Ikuta, K., Scandella, E., and Ludewig, B.
    • Journal Title

      Nat. Immunol.

      Volume: 17 Issue: 12 Pages: 1388-1396

    • DOI

      10.1038/ni.3566

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] Redox-assisted regulation of Ca2+ homeostasis in the endoplasmic reticulum by disulfide reductase ERdj52016

    • Author(s)
      R. Ushioda, A. Miyamotod, M. Inoue, S. Watanabe, M. Okumurae, K. Maegawa, K. Uegaki, S. Fujii, Y. Fukuda, M. Umitsu, J. Takagi, K. Inaba, K. Mikoshibad, and K. Nagata
    • Journal Title

      Proc Natl Acad Sci U S A.

      Volume: 113(41) Issue: 41 Pages: 6055-6063

    • DOI

      10.1073/pnas.1605818113

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Three-dimensional localization of T-cell receptors in relation to microvilli using a combination of super-resolution microscopies.2016

    • Author(s)
      Jung Y, Riven I, Feigelson SW, Kartvelishvily E, Tohya K, Miyasaka M, Alon R, Haran G.
    • Journal Title

      Proc Natl Acad Sci USA

      Volume: 113 Issue: 40

    • DOI

      10.1073/pnas.1605399113

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] ASB7 regulates spindle dynamics and genome integrity by targeting DDA3 for proteasomal degradation.2016

    • Author(s)
      Uematsu K, Okumura F, Tonogai S, Joo-Okumura A, Alemayehu DH, Nishikimi A, Fukui Y, Nakatsukasa K, Kamura T.
    • Journal Title

      Journal of Cell Biology

      Volume: 215 Issue: 1 Pages: 95-106

    • DOI

      10.1083/jcb.201603062

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Upregulation of ANGPTL6 in mouse keratinocytes enhances susceptibility to psoriasis.2016

    • Author(s)
      Tanigawa H, Miyata K, Tian Z, Aoi J, Kadomatsu T, Fukushima S, Ogata A, Takeda N, Zhao J, Zhu S, Terada K, Endo M, Morinaga J, Sugizaki T, Sato M, Morioka MS, Manabe I, Mashimo Y, Hata A, Taketomi Y, Yamamoto K, Murakami M, Araki K, Jinnin M, Ihn H, Oike Y
    • Journal Title

      Scientific Reports

      Volume: 6 Issue: 1 Pages: 34690-34690

    • DOI

      10.1038/srep34690

    • NAID

      120006534970

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Adrenergic control of the adaptive immune response by diurnal lymphocyte recirculation through lymph nodes2016

    • Author(s)
      Suzuki, K., Hayano, Y., Nakai, A., Furuta, F. and Noda, M.
    • Journal Title

      J. Exp. Med.

      Volume: 213 Issue: 12 Pages: 2567-2574

    • DOI

      10.1084/jem.20160723

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Allosteric inhibition of a semaphorin 4D receptor plexin B1 by a high-affinity macrocyclic peptide.2016

    • Author(s)
      Matsunaga Y, Bashiruddin NK, Kitago Y, Takagi J, Suga H.
    • Journal Title

      Cell Chem Biol

      Volume: 23 Issue: 11 Pages: 1341-1350

    • DOI

      10.1016/j.chembiol.2016.09.015

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Thymocytes in Lyve1-CRE/S1pr1f/f mice accumulate in the thymus due to cell-intrinsic loss of sphingosine-1-phosphate receptor expression.2016

    • Author(s)
      Takeda A, Hossain MS, Rantakari P, Simmons S, Sasaki N, Salmi M, Jalkanen S, Miyasaka M.
    • Journal Title

      Front Immunol

      Volume: 7 Pages: 489-489

    • DOI

      10.3389/fimmu.2016.00489

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] Hematopoietic stem cell niches produce lineage-instructive signals to control multipotent progenitor differentiation2016

    • Author(s)
      Gomes, A. C., Hara, T., Lim, V. Y., Herndler-Brandstetter, D., Nevius, E., Sugiyama, T., Tani-ichi, S., Schlenner, S., Richie, E., Rodewald, H., Flavell, R. A., Nagasawa, T., Ikuta, K., and Pereira, J. P.
    • Journal Title

      Immunity

      Volume: 45 Issue: 6 Pages: 1219-1231

    • DOI

      10.1016/j.immuni.2016.11.004

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] Obesity accelerates T-cell senescence in visceral adipose tissue2016

    • Author(s)
      Shirakawa K, Yan X, Shinmura K, Endo J, Kataoka M, Katsumata Y, Yamamoto T, Anzai A, Isobe S, Yoshida N, Itoh H, Manabe I, Sekai M, Hamazaki Y, Fukuda K, Minato N, and Sano M.
    • Journal Title

      J Clin Invest.

      Volume: 126 Issue: 12 Pages: 4626-4639

    • DOI

      10.1172/jci88606

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] Allergin-1 inhibits TLR2-mediated mast cell activation and suppresses dermatitis2016

    • Author(s)
      Tsurusaki S, Tahara-Hanaoka S, Shibagaki S, Miyake S, Imai M, Shibayama S, Kubo M, Shibuya A
    • Journal Title

      International Immunology

      Volume: 28(12) Issue: 12 Pages: 605-609

    • DOI

      10.1093/intimm/dxw046

    • NAID

      120007135029

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Mathematical modeling of atopic dermatitis reveals “double switch” mechanisms underlying 4 common disease phenotypes2016

    • Author(s)
      Domínguez-Hüttinger E, Christodoulides P, Miyauchi K, Irvine AD, Okada-Hatakeyama M, Kubo M, Tanaka RJ
    • Journal Title

      Journal of Allergy and Clinical Immunology

      Volume: - Issue: 6 Pages: 1861-1872.e7

    • DOI

      10.1016/j.jaci.2016.10.026

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] Flow cytometry analysis of thymic epithelial cells and their subpopulation2016

    • Author(s)
      Ohigashi I, Takahama Y
    • Journal Title

      Methods in Molecular Biology

      Volume: 1323 Pages: 65-73

    • DOI

      10.1007/978-1-4939-2809-5_5

    • ISBN
      9781493928088, 9781493928095
    • Related Report
      2016 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Small intestinal eosinophils regulate TH17 cells by producing IL-1 receptor antagonist.2016

    • Author(s)
      Sugawara R, Lee E-J, Jang MS, Jeun E-J, Hong C-P, Kim J-H, Park A, Yun CH, Hong S-W, Kim Y-M, Seoh J-Y, Jung YJ, Surh CD, Miyasaka M, Yang B-G, Jang MH
    • Journal Title

      J Exp Med.

      Volume: 213 Issue: 4 Pages: 555-567

    • DOI

      10.1084/jem.20141388

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] Active and water-soluble form of lipidated Wnt protein is maintained by a serum glycoprotein afamin/α-albumin.2016

    • Author(s)
      Mihara, E., Hirai, H., Yamamoto, H., Tamura-Kawakami, K., Matano, M., Kikuchi, A., Sato, T., and Takagi, J.
    • Journal Title

      Elife

      Volume: 5 Pages: 1-19

    • DOI

      10.7554/elife.11621

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Fibroblastic reticular cell-derived lysophosphatidic acid regulates confined intranodal T-cell motility.2016

    • Author(s)
      Takeda A, Kobayashi D, Aoi K, Sasaki N, Sugiura Y, Igarashi H, Tohya K, Inoue A, Hata E, Akahoshi N, Hayasaka H, Kikuta J, Scandella E, Ludewig B, Ishii S, Aoki J, Suematsu M, Ishii M, Takeda K, Jalkanen S, Miyasaka M, Umemoto E.
    • Journal Title

      Elife

      Volume: 5

    • DOI

      10.7554/elife.10561

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Structure and biological function of ENPP6, a choline-specific glycerophosphodiester-phosphodiesterase2016

    • Author(s)
      Morita J, Kano K, Kato K, Takita H, Skagami H, Yamamoto Y, Mihara E, Ueda H, Sato T, Tokuyama H, Arai H, Asou H, Takagi J, Ishitani R, Nishimasu H, Nureki O, Aoki J
    • Journal Title

      Sci Rep.

      Volume: 6 Issue: 1 Pages: 20995-20995

    • DOI

      10.1038/srep20995

    • URL

      https://localhost/en/publications/d1085467-bb47-4f70-98b0-09d6a10814d8

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Tailored placement of a turn-forming PA tag into the structured domain of a protein to probe its conformational state.2016

    • Author(s)
      Fujii Y, Matsunaga Y, Arimori T, Kitago Y, Ogasawara S, Kaneko M, Kato Y, Takagi J
    • Journal Title

      J Cell Sci.

      Volume: 12- Issue: 7 Pages: 1512-1522

    • DOI

      10.1242/jcs.176685

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Role of histamine H1-receptor on behavioral states and wake maintenance during deficiency of a brain activating system: A study using a knockout mouse model.2016

    • Author(s)
      Parmentier R, Zhao Y, Perier M, Akaoka H, Lintunen M, Hou Y, Panula P, Watanabe T, Franco P, Lin JS
    • Journal Title

      Neuropharmacology

      Volume: なし Pages: 20-34

    • DOI

      10.1016/j.neuropharm.2015.12.014

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] Dynamic spatio-temporal contribution of single b5t+ cortical epithelial precursors to the thymus medulla2016

    • Author(s)
      Mayer CE, Zuklys S, Zhanybekova S, Ohigashi I, Teh HY, Sansom SN, Shikama-Dorn N, Hafen K, Macaulay IC, Deadman ME, Ponting CP, Takahama Y, Hollander GA.
    • Journal Title

      European Journal of Immunology

      Volume: 46 Issue: 4 Pages: 846-856

    • DOI

      10.1002/eji.201545995

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] TGF-β induces the differentiation of human CXCL13-producing CD4+ T cells.2016

    • Author(s)
      Kobayashi S, Watanabe T, Suzuki R, Furu M, Ito H, Ito J, Matsuda S, Yoshitomi H
    • Journal Title

      Eur J Immunol

      Volume: 46 Issue: 2 Pages: 360-371

    • DOI

      10.1002/eji.201546043

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Lysophosphatidic acid receptors LPA4 and LPA6 differentially promote lymphocyte transmigration across high endothelial venules in lymph nodes.2016

    • Author(s)
      Hata E, Sasaki N, Takeda A, Tohya K, Umemoto E, Akahoshi N, Ishii S, Bando K, Abe T, Kano K, Aoki J, Hayasaka H, Miyasaka M
    • Journal Title

      Int Immunol.

      Volume: なし Issue: 6 Pages: 283-292

    • DOI

      10.1093/intimm/dxv072

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] TCR affinity for thymoproteasome-dependent positively selecting peptides conditions antigen responsiveness in CD8(+) T cells2015

    • Author(s)
      Takada K, Van Laethem F, Xing Y, Akane K, Suzuki H, Murata S, Tanaka K, Jameson SC, Singer A, Takahama Y.
    • Journal Title

      Nature Immunology

      Volume: 16 Issue: 10 Pages: 1069-1076

    • DOI

      10.1038/ni.3237

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] Dual functions of Rap1 are crucial for T-cell homeostasis and prevention of spontaneous colitis.2015

    • Author(s)
      Ishihara S, Nishikimi A, Umemoto E, Miyasaka M, Saegusa M, Katagiri K
    • Journal Title

      Nature Communications

      Volume: 6 Issue: 1 Pages: 8982-8982

    • DOI

      10.1038/ncomms9982

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Intronic regulation of Aire expression by Jmjd6 for self-tolerance induction in the thymus.2015

    • Author(s)
      Yanagihara T, Sanematsu F, Sato T, Uruno T, Duan X, Tomino T, Harada Y, Watanabe M, Wang Y, Tanaka Y, Nakanishi Y, Suyama M, Yoshinori F.
    • Journal Title

      Nature Communications

      Volume: 6 Issue: 1 Pages: 8820-8820

    • DOI

      10.1038/ncomms9820

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Thymoproteasomes produce unique peptide motifs for positive selection of CD8(+) T cells.2015

    • Author(s)
      Sasaki K, Takada K, Ohte Y, Kondo H, Sorimachi H, Tanaka K, Takahama Y, Murata S.
    • Journal Title

      Nature Communications

      Volume: 6 Issue: 1 Pages: 7484-7484

    • DOI

      10.1038/ncomms8484

    • NAID

      120006999409

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Aquaporin-3 mediated hydrogen peroxide transport required for NF-kB signaling in epidermal keratinocytes and development of psoriasis.2015

    • Author(s)
      Hara-Chikuma M, Satooka H, Miyachi Y, Watanabe T, Verkman AS
    • Journal Title

      Nat Commun.

      Volume: 6 Issue: 1 Pages: 7454-7454

    • DOI

      10.1038/ncomms8454

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] Adult thymic medullary epithelium is maintained and regenerated by lineage-restricted cells rather than bipotent progenitors2015

    • Author(s)
      Ohigashi I, Zuklys S, Sakata M, Mayer CE, Hamazaki Y, Minato N, Hollander GA, Takahama Y.
    • Journal Title

      Cell Rep.

      Volume: 13 Issue: 7 Pages: 1432-43

    • DOI

      10.1016/j.celrep.2015.10.012

    • NAID

      120006727050

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Interplay of endosomal pH and ligand occupancy in integrin α5β1 ubiquitination, endocytic sorting, and cell migration.2015

    • Author(s)
      Kharitidi D, Apaja PM, Manteghi S, Suzuki K, Malitskaya E, Roldan A, Gingras MC, Takagi J, Lukacs GL, Pause A
    • Journal Title

      Cell Rep.

      Volume: 13 Issue: 3 Pages: 599-609

    • DOI

      10.1016/j.celrep.2015.09.024

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] A CD153+CD4+ T follicular cell population with cell-senescence features plays a crucial role in lupus pathogenesis via osteopontin production.2015

    • Author(s)
      1.Tahir S, Fukushima Y, Sakamoto K, Sato K, Fujita H, Inoue J, Uede T, Hamazaki Y, Hattori M, Minato N.
    • Journal Title

      The Journal of Immunology

      Volume: 194 Issue: 12 Pages: 5725-5735

    • DOI

      10.4049/jimmunol.1500319

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] A G protein-coupled receptor promotes its own surface expression by recruiting a Rap1-dependent signaling cascade.2015

    • Author(s)
      Zhang, Z., Zhang, W., Huang, S., Sun,Q., Wang, Y., Hu, Y., Zhang, Y., Minato, N., Pin, J-P., Su, L., and Liu, J.
    • Journal Title

      J. Cell Sci.

      Volume: 128 Issue: 12 Pages: 2302-2313

    • DOI

      10.1242/jcs.167056

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] The protective function of galectin-9 in liver ischemia and reperfusion injury in mice.2015

    • Author(s)
      Hirofumi Hirao, Yoichiro Uchida, Kentaro Kadono, Hirokazu Tanaka, Toshiro Niki, Akira Yamauchi, Koichiro Hata, Takeshi Watanabe, Hiroaki Terajima, Shinji Uemoto
    • Journal Title

      Liver Transplantation

      Volume: 21 Issue: 7 Pages: 969-981

    • DOI

      10.1002/lt.24159

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Protection from diet-induced obesity and insulin resistance in mice lacking CCL19-CCR7 signaling.2015

    • Author(s)
      Sano T, Iwashita M, Nagayasu S, Yamashita A, Shinjo T, Hashikata A, Asano T, Kushiyama A, Ishimaru N, Takahama Y, Nishimura F
    • Journal Title

      Obesity

      Volume: 23 Issue: 7 Pages: 1460-1471

    • DOI

      10.1002/oby.21127

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Inhibition of MMP-2-Mediated Mast Cell Invasion by NF-κB Inhibitor DHMEQ in Mast Cells2015

    • Author(s)
      Noma N, Asagiri M, Takeiri M, Ohmae S, Takemoto K, Iwaisako K, Minato N, Maeda-Yamamoto M, Simizu S, Umezawa K
    • Journal Title

      Int Arch Allergy Immunol

      Volume: 166 Issue: 2 Pages: 84-90

    • DOI

      10.1159/000371419

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Structural basis for amyloidogenic peptide recognition by sorLA.2015

    • Author(s)
      Kitago Y, Nagae M, Nakata Z, Yagi-Utsumi M, Takagi-Niidome S, Mihara E, Nogi T, Kato K, Takagi J.
    • Journal Title

      Nat Struct Mol Biol.

      Volume: 22 Issue: 3 Pages: 199-206

    • DOI

      10.1038/nsmb.2954

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Real-time tracking of cell cycle progression during CD8(+) effector and memory T-cell differentiation.2015

    • Author(s)
      Kinjyo I, Qin J, Tan SY, Wellard CJ, Mrass P, Ritchie W, Doi A, Cavanagh LL, Tomura M, Sakaue-Sawano A, Kanagawa O, Miyawaki A, Hodgkin PD, Weninger W.
    • Journal Title

      Nat Commun.

      Volume: 6 Issue: 1 Pages: 6301-6301

    • DOI

      10.1038/ncomms7301

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] The thymic cortical epithelium determines the TCR repertoire of IL-17-producing gdT cells.2015

    • Author(s)
      Nitta T, Muro R, Shimizu Y, Nitta S, Oda H, Ohte Y, Goto M, Yanobu R, Narita T, Takayanagi H, Yasuda H, Okamura T, Murata T, Suzuki H.
    • Journal Title

      EMBO Rep.

      Volume: なし Issue: 5 Pages: 638-653

    • DOI

      10.15252/embr.201540096

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed
  • [Journal Article] IL-1β in eosinophil-mediated small intestinal homeostasis and IgA production2015

    • Author(s)
      Jung Y, Wen T, Mingler MK, Wang YH, Chaplin DD, Lee EH, Jang MH, Woo SY, Seoh JY, Miyasaka M, Rothenberg ME.
    • Journal Title

      Mucosal Immunol.

      Volume: なし Issue: 4 Pages: 930-942

    • DOI

      10.1038/mi.2014.123

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] JNK Regulatory Molecule G5PR Induces IgG Autoantibody-Producing Plasmablasts from Peritoneal B1a Cells.2015

    • Author(s)
      Kitabatake M, Soma M, Zhang T, Kuwahara K, Fukushima Y, Nojima T, Kitamura D, Sakaguchi N.
    • Journal Title

      J Immunol.

      Volume: 194 Issue: 4 Pages: 1480-1488

    • DOI

      10.4049/jimmunol.1401127

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] A genome-wide analysis identifies a Notch-RBP-Jκ-IL-7Rα axis that controls IL-17-producing γδ T cell homeostasis in mice.2015

    • Author(s)
      Nakamura M, Shibata K, Hatano S, Sato T, Ohkawa Y, Yamada H, Ikuta K, Yoshikai Y.
    • Journal Title

      J Immunol.

      Volume: 194 Issue: 1 Pages: 243-251

    • DOI

      10.4049/jimmunol.1401619

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Egress of Mature Murine Regulatory T Cells from the Thymus Requires RelA.2015

    • Author(s)
      Fukazawa T, Hiraiwa N, Umemura T, Mise-Omata S, Obata Y, Doi T.
    • Journal Title

      J Immunol.

      Volume: 194 Issue: 7 Pages: 3020-3028

    • DOI

      10.4049/jimmunol.1302756

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Crucial role of the Rap G protein signal in Notch activation and leukemogenicity of T-cell acute lymphoblastic leukemia.2015

    • Author(s)
      Doi K, Imai T, Kressler C, Yagita H, Agata Y, Vooijs M, Hamazaki Y, Inoue J, Minato N.
    • Journal Title

      Sci Rep.

      Volume: 5 Issue: 1 Pages: 7978-7985

    • DOI

      10.1038/srep07978

    • NAID

      120005555511

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Axl phosphorylates Elmo scraffold proteins to promote Rac activation and cell invasion.2015

    • Author(s)
      Abu-Thuraia A, Gauthier R, Chidiac R, Fukui Y, Screaton RA, Gratton JP, Cote JF.
    • Journal Title

      Mol Cell Biol.

      Volume: 35 Issue: 1 Pages: 76-87

    • DOI

      10.1128/mcb.00764-14

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Anchorage-dependent multicellular aggregate formation induces CD44 high cancer stem cell-like ATL cells in an NF-κB- and vimentin-dependent manner.2015

    • Author(s)
      Miyatake Y, Sheehy N, Ikeshita S, Hall WW, Kasahara M.
    • Journal Title

      Cancer Lett.

      Volume: 357 Issue: 1 Pages: 355-363

    • DOI

      10.1016/j.canlet.2014.11.055

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] The SKINT1-like gene is inactivated in hominoids but not in all primate species: implications for the origin of epidermal dendritic T cells.2015

    • Author(s)
      Mohamed R H, Sutoh Y, Itoh Y, Miyatake Y, Otsuka N, Ogasawara K, Kasahara M.
    • Journal Title

      PLoS ONE.

      Volume: 10 Issue: 4 Pages: e0123258-e0123258

    • DOI

      10.1371/journal.pone.0123258

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] The HIV-1 gp120/CXCR4 axis promotes CCR7 ligand-dependent CD4 T cell migration: CCR7 homo- and CCR7/CXCR4 hetero-oligomer formation as a possible mechanism for up-regulation of functional CCR7.2015

    • Author(s)
      Hayasaka H, Kobayashi D, Yoshimura H, Nakayama EE, Shioda T, Miyasaka M.
    • Journal Title

      PLoS ONE.

      Volume: 10 Issue: 2 Pages: 1371-1371

    • DOI

      10.1371/journal.pone.0117454

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] New immunosuppressive strategies for transplantation based on pluripotent stem cell (PSC)-derived immunoregulatory cells.2015

    • Author(s)
      Seino K, Wada H, Baghdadi M.
    • Journal Title

      Stem Cell Transl Invest

      Volume: 2 Pages: 1-6

    • DOI

      10.14800/scti.504

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Decreased expression of thymus-specific proteasome subunit β5t in Down syndrome patients.2015

    • Author(s)
      Tomaru U, Tsuji T, Kiuchi S, Ishizu A, Suzuki A, Otsuka N, Ito T, Ikeda H, Fukasawa Y, Kasahara M.
    • Journal Title

      Histopathology.

      Volume: なし Issue: 2 Pages: 235-244

    • DOI

      10.1111/his.12642

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Establishment of a vascular endothelial cell-reactive type II NKT cell clone from a rat model of autoimmune vasculitis.2015

    • Author(s)
      Iinuma C, Waki M, Kawakami A, Yamaguchi M, Tomaru U, Sasaki N, Masuda S, Matsui Y, Iwasaki S, Baba T, Kasahara M, Yoshiki T, Paletta D, Herrmann T, Ishizu A.
    • Journal Title

      Int Immunol.

      Volume: 27 Issue: 2 Pages: 105-114

    • DOI

      10.1093/intimm/dxu088

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Pancreatic cancer cells express CD44 variant 9 and multidrug resistance protein 1 during mitosis.2015

    • Author(s)
      Kiuchi S, Ikeshita S, Miyatake Y, Kasahara M.
    • Journal Title

      Exp Mol Pathol.

      Volume: 98 Issue: 1 Pages: 41-46

    • DOI

      10.1016/j.yexmp.2014.12.001

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Immunohistochemical Validation and Expression Profiling of NKG2D Ligands in a Wide Spectrum of Human Epithelial Neoplasms.2015

    • Author(s)
      Fujita H, Hatanaka Y, Sutoh Y, Suzuki Y, Oba K, Hatanaka KC, Mitsuhashi T, Otsuka N, Fugo K, Kasahara M, Matsuno Y.
    • Journal Title

      J Histochem Cytochem.

      Volume: 63 Issue: 3 Pages: 217-227

    • DOI

      10.1369/0022155414563800

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Cytotoxic T lymphocytes block tumor growth both by lytic activity and IFN-γ-dependent cell cycle arrest.2015

    • Author(s)
      Matsushita H, Hosoi A, Ueha S, Abe J, Fujieda N, Tomura M, Maekawa R, Matsushima K, Ohara O, Kakimi K.
    • Journal Title

      Cancer Immunol Res.

      Volume: 3 Issue: 1 Pages: 26-36

    • DOI

      10.1158/2326-6066.cir-14-0098

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Dermal Vγ4(+) γδ T Cells Possess a Migratory Potency to the Draining Lymph Nodes and Modulate CD8(+) T-Cell Activity through TNF-α Production.2015

    • Author(s)
      Nakamizo S, Egawa G, Tomura M, Sakai S, Tsuchiya S, Kitoh A, Honda T, Otsuka A, Nakajima S, Dainichi T, Tanizaki H, Mitsuyama M, Sugimoto Y, Kawai K, Yoshikai Y, Miyachi Y, Kabashima K.
    • Journal Title

      Journal of Investigative Dermatology

      Volume: 135 Issue: 4 Pages: 1007-1015

    • DOI

      10.1038/jid.2014.516

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Foxc1 is a critical regulator of haematopoietic stem/progenitor cell niche formation2014

    • Author(s)
      Omatsu Y, Seike M, Sugiyama T, Kume T, Nagasawa T.
    • Journal Title

      Nature

      Volume: 508 Issue: 7497 Pages: 536-540

    • DOI

      10.1038/nature13071

    • Related Report
      2014 Annual Research Report 2013 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Elephant shark genome provides unique insights into gnathostome evolution.2014

    • Author(s)
      Venkatesh B, Lee AP, Ravi V, Maurya AK, Lian MM, Swann JB, Ohta Y, Flajnik MF, Sutoh Y, Kasahara M, Hoon S, Gangu V, Roy SW, Irimia M, Korzh V, Kondrychyn I, Lim ZW, Tay BH, Tohari S, Kong KW, Ho S, Lorente-Galdos B, Quilez J, Marques-Bonet T, Raney BJ, Ingham PW, Tay A
    • Journal Title

      Nature

      Volume: 505 Issue: 7482 Pages: 174-179

    • DOI

      10.1038/nature12826

    • Related Report
      2014 Annual Research Report 2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Neutrophils scan for activated platelets to initiate inflammation.2014

    • Author(s)
      Sreeramkumar V, Adrover JM, Ballesteros I, Cuartero MI, Rossaint J, Bilbao I, Nacher M, Pitaval C, Radovanovic I, Fukui Y, McEver RP, Filippi M-D, Lizasoain I, Ruiz-Cabello J, Zarbock A, Moro MA, Hidalgo A.
    • Journal Title

      Science

      Volume: 346 Issue: 6214 Pages: 1234-1238

    • DOI

      10.1126/science.1256478

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Pathogenic conversion of Foxp3+ T cells into TH17 cells in autoimmune arthritis.2014

    • Author(s)
      Komatsu, N., Okamoto, K., Sawa, S., Nakashima, T., Oh-hora, M., Kodama, T., Tanaka, S., Bluestone, JA. and Takayanagi, H.
    • Journal Title

      Nature Medicine

      Volume: 20 Issue: 1 Pages: 62-68

    • DOI

      10.1038/nm.3432

    • Related Report
      2014 Annual Research Report 2013 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Medullary thymic epithelial stem cells maintain a functional thymus to ensure lifelong central T cell tolerance.2014

    • Author(s)
      Sekai M, Hamazaki Y, Minato N.
    • Journal Title

      Immunity.

      Volume: 41 Issue: 5 Pages: 753-761

    • DOI

      10.1016/j.immuni.2014.10.011

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Thromboxane A2 acts as tonic immunoregulator by preferentialdisruption of low-avidity CD4+ T cell-dendritic cell interactions.2014

    • Author(s)
      Moalli F, Cupovic J, Thelen F, Halbherr P, Fukui Y, Narumiya S, Ludewig B, Stein JV.
    • Journal Title

      J Exp Med.

      Volume: 211 Issue: 13 Pages: 2507-2517

    • DOI

      10.1084/jem.20140137

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed
  • [Journal Article] DOCK5 functions as a key signaling adaptor that links FcεRI signals to microtubule dynamics during mast cell degranulation.2014

    • Author(s)
      Ogawa K, Tanaka Y, Uruno T, Duan X, Harada Y, et al.
    • Journal Title

      J. Exp. Med.

      Volume: (In press) Issue: 7 Pages: 1407-1419

    • DOI

      10.1084/jem.20131926

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] In vivo imaging reveals PKA regulation of ERK activity during neutrophil recruitment to inflamed intestines.2014

    • Author(s)
      Mizuno, R., Kamioka, Y., Kabashima, K., Imajo, M., Sumiyama, K., Nakasho, E., Ito, T., Hamazaki, Y., Okuchi, Y., Sakai, Y., Kiyokawa, E., and Matsuda, M.
    • Journal Title

      J Exp Med

      Volume: 211 Issue: 6 Pages: 1123-36

    • DOI

      10.1084/jem.20132112

    • NAID

      120005439165

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Novel role for SORLA/SORL1 as lysosomal sorting receptor for amyloid-b peptide is impaired by familial Alzheimer disease mutation2014

    • Author(s)
      Caglayan S, Takagi-Niidome S, Liao F, Carlo A-S, Schmidt V, Burgert T, Kitago Y, Fuchtbauer E-M, Fachtbauer A, Holtzman DM, Takagi J, and Wilnow TE
    • Journal Title

      Science Translational Medicine

      Volume: 6(223) Issue: 223

    • DOI

      10.1126/scitranslmed.3007747

    • Related Report
      2014 Annual Research Report 2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Toll-like receptor 4 and MAIR-II/CLM-4/LMIR2 immunoreceptor regulate VLA-4-mediated infammatory monocyte migration2014

    • Author(s)
      Naoya T otsuka, Yun-Gi Kim, Kazumasa Kanemaru, Kouta Niizuma, Eiji Umemoto, Kei Nagai, Satoko T ahara-Hanaoka, Chigusa Nakahasi-Oda, Shin-ichiro Honda, Masayuki Miyasaka, Kazuko Shibuya & Akira Shibuya
    • Journal Title

      Nature Communications

      Volume: 5:4710 Issue: 1 Pages: 4710-4710

    • DOI

      10.1038/ncomms5710

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Generation of colonic IgA-secreting cells in the cecal patch2014

    • Author(s)
      Masahata, K., Umemoto, E., Kayama, H., Kotani, M., Nakamura, S., Kurakawa, T., Kikuta, J., Gotoh, K., Motooka, D., Sato, S., Higuchi, T., Baba, Y., Kurosaki, T., Kinoshita, M., Shimada, Y., Kimura, T., Okumura, R., Takeda, A., Tajima, M., Yoshie, O., Fukuzawa, M., Kiyono, H., Fagarasan, S., Iida, T., Ishii, M., Takeda, K
    • Journal Title

      Nature Comm

      Volume: 5 Issue: 1 Pages: 3704-3704

    • DOI

      10.1038/ncomms4704

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Spleen supports a pool of innate-like B cells in white adipose tissue that protects against obesity-associated insulin resistance2014

    • Author(s)
      Wu L, Parekh V V, Hsiao J, Kitamura D, Van Kaer L.
    • Journal Title

      Proc Natl Acad Sci USA.

      Volume: 111 Issue: 43 Pages: 4638-4647

    • DOI

      10.1073/pnas.1324052111

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Tracking of intertissue migration reveals the origins of tumor-infiltrating monocytes.2014

    • Author(s)
      Shand FH, Ueha S, Otsuji M, Koid SS, Shichino S, Tsukui T, Kosugi-Kanaya M, Abe J, Tomura M, Ziogas J, Matsushima K.
    • Journal Title

      Proc Natl Acad Sci USA.

      Volume: 111 Issue: 21 Pages: 7771-7776

    • DOI

      10.1073/pnas.1402914111

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Leucophores are similar to xanthophores in their specification and differentiation processes in medaka2014

    • Author(s)
      T. Kimura, Y. Nagao, H. Hashimoto, Y. Yamamoto-Shiraishi, S. Yamamoto, T. Yabe, S. Takada, M. Kinoshita, A. Kuroiwa and K. Naruse
    • Journal Title

      Proc Natl Acad Sci U S A

      Volume: 111 Issue: 20 Pages: 1986767-1986767

    • DOI

      10.1073/pnas.1311254111

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Characterization of the interleukin-15 niche in primary and secondary lymphoid organs in vivo.2014

    • Author(s)
      Cui G, Hara T, Simmons S, Wagatsuma K, Abe A, Miyachi H, Kitano S, Ishii M, Tani-ichi S, Ikuta K.
    • Journal Title

      Proc Natl Acad Sci USA

      Volume: 111 Issue: 5 Pages: 1915-1920

    • DOI

      10.1073/pnas.1318281111

    • Related Report
      2014 Annual Research Report 2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Rab13 acts downstream of the kinase Mst1 to deliver the integrin LFA-1 to the cell surface for lymphocyte trafficking.2014

    • Author(s)
      Nishikimi A, Ishihara S, Ozawa M, Etoh K, Fukuda M, Kinashi T and Katagiri K
    • Journal Title

      Sci. Signal.

      Volume: Vol. 7, Issue 336 Issue: 336

    • DOI

      10.1126/scisignal.2005199

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] DOCK2 is critical for CD8+TCR- graft facilitating cells to enhance engraftment of hematopoietic stem and progenitor cells.2014

    • Author(s)
      Wen Y, Elliott MJ, Huang Y, Miller TO, Corbin DR, Hussain L-R, Ratajczak MZ, Fukui Y, Ildstad ST.
    • Journal Title

      Stem Cells.

      Volume: 32 Issue: 10 Pages: 2732-2743

    • DOI

      10.1002/stem.1780

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed
  • [Journal Article] NKG2D triggers cytotoxicity in murine epidermal γδ T cells via PI3K-dependent, Syk/ZAP70-independent signaling pathway.2014

    • Author(s)
      Ibusuki A, Kawai K, Yoshida S, Uchida Y, Nitahara-Takeuchi A, Kuroki K, Kajikawa M, Ose T, Maenaka K, Kasahara M, Kanekura T.
    • Journal Title

      J Invest Dermatol

      Volume: 134 Issue: 2 Pages: 396-404

    • DOI

      10.1038/jid.2013.353

    • Related Report
      2014 Annual Research Report 2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] A structure-based model of substrate discrimination by a non-canonical PDZ tandem in the intramembrane-cleaving protease RseP.2014

    • Author(s)
      檜作 洋平, 小田 隆, 田畑 早苗, 川上-田村 恵子, 大井 里香, 佐藤 衛, 高木 淳一, 秋山 芳展, 禾 晃和
    • Journal Title

      Structure

      Volume: 22 Issue: 2 Pages: 326-336

    • DOI

      10.1016/j.str.2013.12.003

    • Related Report
      2014 Annual Research Report 2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] P-Rex1 directly activates RhoG to regulate GPCR-driven Rac signalling and actin polarity in neutrophils.2014

    • Author(s)
      Damoulakis G, Gambardella L, Rossman K, Lawson C, Anderson K, Fukui Y, Welch H, Der C, Stephens L, Hawkins P.
    • Journal Title

      J Cell Sci.

      Volume: 127 Pages: 2589-2600

    • DOI

      10.1242/jcs.153049

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed
  • [Journal Article] DOCK2 and DOCK5 act additively in neutrophils to regulate chemotaxis, superoxide production, and extracellular trap formation.2014

    • Author(s)
      Watanabe M, Terasawa M, Miyano K, Yanagihara T, Uruno T, Sanematsu F, Nishikimi A, Cote JF, Sumimoto H, Fukui Y.
    • Journal Title

      J Immunol.

      Volume: 193 Issue: 11 Pages: 5660-5667

    • DOI

      10.4049/jimmunol.1400885

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Lymph Node Stromal Cells Negatively Regulate Antigen-Specific CD4+ T Cell Responses.2014

    • Author(s)
      Abe J, Shichino S, Ueha S, Hashimoto S, Tomura M, Inagaki Y, Stein JV, Matsushima K.
    • Journal Title

      J Immunol.

      Volume: 193 Issue: 4 Pages: 1636-1644

    • DOI

      10.4049/jimmunol.1302946

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Gp49B-mediated negative regulation of antibody production by memory and marginal zone B cells.2014

    • Author(s)
      Fukao S, Haniuda K, Nojima T, Takai T, Kitamura D.
    • Journal Title

      J Immunol.

      Volume: 193 Issue: 2 Pages: 635-644

    • DOI

      10.4049/jimmunol.1302772

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Murine Spleen Tissue Regeneration from Neonatal Spleen Capsule Requires Lymphotoxine Priming of Stromal Cells.2014

    • Author(s)
      Tan J, Watanabe T.
    • Journal Title

      J Immunol.

      Volume: 193 Issue: 3 Pages: 1194-1203

    • DOI

      10.4049/jimmunol.1302115

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Autotaxin Produced by Stromal Cells Promotes LFA-1-Independent and Rho-Dependent Interstitial T Cell Motility2014

    • Author(s)
      Katakai T., Kondo N., Ueda Y., and Kinashi T
    • Journal Title

      J Immunol

      Volume: 193 Issue: 2 Pages: 617-626

    • DOI

      10.4049/jimmunol.1400565

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Genomic sequence analysis of the major histocompatibility complex (MHC) class I G/F segment in common marmoset (Callithrix jacchus)2014

    • Author(s)
      Kono A, Brameier M, Roos C, Suzuki S, Shigenari A, Kametani Y, Kitaura K, Matsutani T, Suzuki R, Inoko H, Walter L, Shiina T
    • Journal Title

      J Immunol.

      Volume: 192 Issue: 7 Pages: 3239-3246

    • DOI

      10.4049/jimmunol.1302745

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Thymic medullary epithelium and thymocyte self-tolerance require cooperation between CD28-CD80/86 and CD40-CD40L costimulatory pathways.2014

    • Author(s)
      Williams JA, Zhang J, Jeon H, Nitta T, Ohigashi I, Klug D, Kruhlak MJ, Choudhury B, Sharrow SO, Granger L, Adams A, Eckhaus MA, Jenkinson SR, Richie ER, Gress RE, Takahama Y, Hodes RJ.
    • Journal Title

      J Immunol

      Volume: 192 Issue: 2 Pages: 630-640

    • DOI

      10.4049/jimmunol.1302550

    • Related Report
      2014 Annual Research Report 2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Tracking and quantification of dendritic cell migration and antigen trafficking between the skin and lymph nodes.2014

    • Author(s)
      Tomura M, Hata A, Matsuoka S, Shand FH, Nakanishi Y, Ikebuchi R, Ueha S, Tsutsui H, Inaba K, Matsushima K, Miyawaki A, Kabashima K, Watanabe T, Kanagawa O.
    • Journal Title

      Sci Rep.

      Volume: 4 Issue: 1 Pages: 6030-6030

    • DOI

      10.1038/srep06030

    • NAID

      120005749847

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] A novel CD3-specific antibody induces immunosuppression via impaired phosphorylation of LAT and PLCγ1 following T-cell stimulation2014

    • Author(s)
      Shiheido H, Aoyama T, Takahashi H, Hanaoka K, Abe T, Nishida E, Chen C, Koga O, Hikida M, Shibagaki Y, Morita A, Nikawa T, Hattori S, Watanabe T, Shimizu J.
    • Journal Title

      Eur J Immunol

      Volume: in press Issue: 6 Pages: 1770-1780

    • DOI

      10.1002/eji.201344146

    • Related Report
      2014 Annual Research Report 2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Gimap3 and Gimap5 cooperate to maintain T-cell numbers in the mouse2014

    • Author(s)
      Yano K, Carter C, Yoshida N, Abe T, Yamada A, Nitta T, Ishimaru N, Takada K, Butcher GW, Takahama Y.
    • Journal Title

      Eur J Immunol

      Volume: 44 Issue: 2 Pages: 561-572

    • DOI

      10.1002/eji.201343750

    • Related Report
      2014 Annual Research Report 2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Dental pulp dendritic cells migrate to regional lymph nodes2014

    • Author(s)
      Bhingare AC, Ohno T, Tomura M, Zhang C, Aramaki O, Otsuki M, Tagami J, Azuma M
    • Journal Title

      J Dental Res

      Volume: 93 Issue: 3 Pages: 288-293

    • DOI

      10.1177/0022034513518223

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Activation of fibroblast-like synoviocytes derived from rheumatoid arthritis via lysophosphatidic acid - lysophosphatidic acid receptor 1 cascade.2014

    • Author(s)
      Miyabe Y, Miyabe C, Iwai Y, Yokoyama W, Sekine C, Sugimoto K, Harigai M, Miyasaka M, Miyasaka N, Nanki T.
    • Journal Title

      Arthritis Res Ther.

      Volume: 16 Issue: 5 Pages: 461-461

    • DOI

      10.1186/s13075-014-0461-9

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Meis1 regulates epidermal stem cells and is required for skin tumorigenesis2014

    • Author(s)
      Okumura K, Saito M, Isogai E, Aoto Y, Hachiya T, Sakakibara Y, Katsuragi Y, Hirose S, Kominami R, Goitsuka R, Nakamura T and Wakabayashi Y.
    • Journal Title

      PLOS ONE

      Volume: 9 Issue: 7 Pages: e102111-e102111

    • DOI

      10.1371/journal.pone.0102111

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Induction of Macrophage-Like Immunosuppressive Cells from Mouse ES Cells That Contribute to Prolong Allogeneic Graft Survival.2014

    • Author(s)
      Kudo H, Wada H, Sasaki H, Tsuji H, Otsuka R, Baghdadi M, Kojo S, Chikaraishi T, Seino K.
    • Journal Title

      PLoS One.

      Volume: 9 Issue: 10 Pages: 1-9

    • DOI

      10.1371/journal.pone.0111826

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Retinoic acid and GM-CSF coordinately induce retinal dehydrogenase 2 (RALDH2) expression through cooperation between the RAR/RXR complex and Sp1 in dendritic cells2014

    • Author(s)
      Ohoka Y, Yokota-Nakatsuma A, Maeda N, Takeuchi H, and Iwata M
    • Journal Title

      PLoS ONE

      Volume: 9(5) Issue: 5 Pages: e96512-e96512

    • DOI

      10.1371/journal.pone.0096512

    • Related Report
      2014 Annual Research Report 2013 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Modulation of the human T cell response by a novel non-mitogenic anti-CD3 antibody.2014

    • Author(s)
      Shiheido H, Chen C, Hikida M, Watanabe T, Shimizu J.
    • Journal Title

      PLoS One.

      Volume: 9 Issue: 4 Pages: e94324-e94324

    • DOI

      10.1371/journal.pone.0094324

    • Related Report
      2014 Annual Research Report 2013 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] A novel and effective cancer immunotherapy mouse model using antigen-specific B cells selected in vitro.2014

    • Author(s)
      Moutai T, Yamana H, Nojima T and Kitamura D.
    • Journal Title

      PLOS ONE

      Volume: 9 Issue: 3 Pages: 92732-92732

    • DOI

      10.1371/journal.pone.0092732

    • Related Report
      2014 Annual Research Report 2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Enteroendocrine cells are specifically marked by cell surface expression of claudin-4 in mouse small intestine2014

    • Author(s)
      Nagatake T, Fujita H, Minato N, Hamazaki Y.
    • Journal Title

      PLoS One

      Volume: 9 Issue: 3 Pages: e90638-e90638

    • DOI

      10.1371/journal.pone.0090638

    • Related Report
      2014 Annual Research Report 2013 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Meis1 is required for the maintenance of postnatal thymic epithelial cells.2014

    • Author(s)
      Hirayama T, Asano Y, Iida H, Watanabe T, Nakamura T, Goitsuka R.
    • Journal Title

      PLOS One

      Volume: 9 Issue: 3 Pages: e89885-e89885

    • DOI

      10.1371/journal.pone.0089885

    • Related Report
      2014 Annual Research Report 2013 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Differential Function of Themis CABIT Domains during T Cell Development.2014

    • Author(s)
      Okada T, Nitta T, Kaji K, Takashima A, Oda H, Tamehiro N, Goto M, Okamura T, Patrick MS, Suzuki H.
    • Journal Title

      PLoS One

      Volume: 9 Issue: 2 Pages: e89115-e89115

    • DOI

      10.1371/journal.pone.0089115

    • Related Report
      2014 Annual Research Report 2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Homeodomain transcription factor meis1 is a critical regulator of adult bone marrow hematopoiesis.2014

    • Author(s)
      Ariki R, Morikawa S, Mabuchi Y, Suzuki S, Nakatake M, Yoshioka K, Hidano S, Nakauchi H, Matsuzaki Y, Nakamura T, Goitsuka R.
    • Journal Title

      PLoS One.

      Volume: 9 Issue: 2 Pages: 87646-87646

    • DOI

      10.1371/journal.pone.0087646

    • Related Report
      2014 Annual Research Report 2013 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Crystal structure of the lamprey variable-lymphocyte receptor C reveals an unusual feature in its N-terminal capping module2014

    • Author(s)
      Kanda R, Sutoh Y, Kasamatsu J, Maenaka K, Kasahara M, Ose T
    • Journal Title

      PLoS One

      Volume: 23 Issue: 1 Pages: e85875-e85875

    • DOI

      10.1371/journal.pone.0085875

    • Related Report
      2014 Annual Research Report 2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Decreased proteasomal activity causes photoreceptor degeneration in mice.2014

    • Author(s)
      Ando R, Noda K, Tomaru U, Kamoshita M, Ozawa Y, Notomi S, Hisatomi T, Noda M, Kanda A, Ishibashi T, Kasahara M, Ishida S.
    • Journal Title

      Invest Ophthalmol Vis Sci.

      Volume: 55 Issue: 7 Pages: 4682-4690

    • DOI

      10.1167/iovs.13-13272

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] NF-κB RELA-deficient bone marrow macrophages fail to support bone formation and to maintain the hematopoietic niche after lethal irradiation and stem cell transplantation.2014

    • Author(s)
      Mise-Omata S, Alles N, Fukazawa T, Aoki K, Ohya K, Jimi E, Obata Y, Doi T.
    • Journal Title

      Int Immunol.

      Volume: 26 Issue: 11 Pages: 607-618

    • DOI

      10.1093/intimm/dxu062

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed
  • [Journal Article] NKG2D functions as an activating receptor on natural killer cells in common marmoset (callithrix jacchus).2014

    • Author(s)
      Watanabe M, Kudo Y, Kawano M, Nakayama M, Nakamura K, Kameda M, Ebara M, Sato T, Nakamura M, Omine K, Kametani Y, Suzuki R, Ogasawara K.
    • Journal Title

      Int Immunol.

      Volume: 26 Issue: 11 Pages: 597-606

    • DOI

      10.1093/intimm/dxu053

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Increased number of Hassall's corpuscles in myasthenia gravis patients with thymic hyperplasia2014

    • Author(s)
      Matsui N, Ohigashi I, Tanaka K, Nagayama Y, Kondo K, Kitagawa T, Yamashita S, Nomura Y, Takahama Y, Kaji R.
    • Journal Title

      J Neuroimmunol

      Volume: 269 Issue: 1-2 Pages: 56-61

    • DOI

      10.1016/j.jneuroim.2014.01.011

    • Related Report
      2014 Annual Research Report 2013 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Copy number and sequence variation of leucine-rich repeat modules suggests distinct functional constraints operating on variable lymphocyte receptors expressed by agnathan T cell-like and B cell-like lymphocytes.2014

    • Author(s)
      Sutoh Y, Kasahara M.
    • Journal Title

      Immunogenetics.

      Volume: 66 Issue: 6 Pages: 403-409

    • DOI

      10.1007/s00251-014-0773-6

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Corticomedullary differentiation and maturational arrest in thymomas.2014

    • Author(s)
      Storbel P, Hartmann E, Rosenwald A, Kalla J, Ott G, Schalke B, Kasahara M, Tomaru U, Marx A.
    • Journal Title

      Histopathology

      Volume: 64 Issue: 4 Pages: 557-566

    • DOI

      10.1111/his.12279

    • Related Report
      2014 Annual Research Report 2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] MICA/B expression in macrophage foam cells infiltrating atherosclerotic plaques.2014

    • Author(s)
      Ikeshita S, Miyatake Y, Otsuka N, Kasahara M.
    • Journal Title

      Exp Mol Pathol.

      Volume: 97 Issue: 1 Pages: 171-175

    • DOI

      10.1016/j.yexmp.2014.07.002

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Expression of thymoproteasome subunit β5t in type AB thymoma.2014

    • Author(s)
      Yamada Y, Tomaru U, Ishizu A, Kiuchi T, Kasahara M, Matsuno Y.
    • Journal Title

      J Clin Pathol.

      Volume: 67 Issue: 3 Pages: 276-278

    • DOI

      10.1136/jclinpath-2013-201930

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Gimap3 and Gimap5 cooperate to maintain T-cell numbers in the mouse.2014

    • Author(s)
      Yano K, Carter C, Yoshida N, Abe T, Yamada A, Nitta T, Ishimaru N, Takada K, Butcher GW, Takahama Y.
    • Journal Title

      Eur J Immunol

      Volume: 44 Issue: 2 Pages: 561-572

    • DOI

      10.1016/j.bbrc.2014.05.023

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Environments of B cell development.2014

    • Author(s)
      Tsuneto M, Kajikhina E, Seiler K, Reimer A, Tornack J, Bouquet C, Simmons S, Knoll M, Wolf I, Tokoyoda K, Hauser A, Hara T, Tani-Ichi S, Ikuta K, Grun J. R, Grutzkau A, Engels N, Wienands J, Yanagisawa Y, Ohnishi K , Melchers F.
    • Journal Title

      Immunol Lett.

      Volume: 157 Issue: 1-2 Pages: 60-63

    • DOI

      10.1016/j.imlet.2013.11.011

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Generation of a Tlx1(CreER-Venus) knock-in mouse strain for the study of spleen development.2014

    • Author(s)
      Nakahara R, Kawai Y, Oda A, Nishimura M, Murakami A, Azuma T, Kaifu T, Goitsuka, R.
    • Journal Title

      Genesis.

      Volume: 52 Issue: 11 Pages: 916-923

    • DOI

      10.1002/dvg.22829

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Differentiation ability of multipotent hematopoietic stem/progenitor cells detected by a porcine specific anti-CD117 monoclonal antibody2014

    • Author(s)
      Ohshima S, Mori S, Shigenari A, Miyamoto A, Takasu M, Imaeda N, Nunomura S, Okayama Y, Tanaka M, Kitagawa H, Kulski JK, Inoko H, Ando A, Kametani Y.
    • Journal Title

      BioScience Trends

      Volume: 8 Issue: 6 Pages: 308-315

    • DOI

      10.5582/bst.2014.01084

    • NAID

      130005054671

    • ISSN
      1881-7815, 1881-7823
    • Related Report
      2014 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Defect of tropomyosin-related kinase B isotype expression in ovarian clear cell adenocarcinoma.2014

    • Author(s)
      Goto Y, Kametani Y, Kikugawa A, Tsuda B, Miyazawa M, Kajiwara H, Terao Y, Takekoshi S, Nakamura N, Takeda S, Mikami M.
    • Journal Title

      Biosci Trends.

      Volume: 8 Pages: 93-100

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed
  • [Journal Article] PA tag: a versatile protein tagging system using a super high affinity antibody against a dodecapeptide derived from human podoplanin2014

    • Author(s)
      Fujii Y, Kaneko M, Neyazaki M, Nogi T, Kato Y, Takagi J.
    • Journal Title

      Protein Expr Purif

      Volume: 95 Pages: 240-247

    • DOI

      10.1016/j.pep.2014.01.009

    • Related Report
      2014 Annual Research Report 2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] The Rac-specific exchange factors Dock1 and Dock5 are dispensable for the establishment of the glomerular filtration barrier in vivo.2014

    • Author(s)
      Laurin M, Dumouchel A, Fukui Y, Cote J-F.
    • Journal Title

      Small GTPases

      Volume: 4 Issue: 4 Pages: 221-230

    • DOI

      10.4161/sgtp.27430

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Human T cells expressing BEND3 on their surface represent a novel subpopulation that preferentially produces IL-6 and IL-8.2014

    • Author(s)
      Shiheido H, Kitagori K, Sasaki C, Kobayashi S, Aoyama T, Urata K, Oku T, Hirayama Y, Yoshitomi H, Hikida M, Yoshifuji H, Mimori T, Watanabe T, Shimizu J.
    • Journal Title

      Immunity, Inflammation and Disease.

      Volume: 2 Issue: 1 Pages: 35-43

    • DOI

      10.1002/iid3.17

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Genomic sequence analysis of the major histocompatibility complex (MHC) class I G/F segment in common marmoset (Callithrix jacchus).2014

    • Author(s)
      Kono A, Brameier M, Roos C, Suzuki S, Shigenari A, Kametani Y, Kitaura K, Suzuki R, Inoko H, Walter L, Shiina T.
    • Journal Title

      J Immunol

      Volume: 192 Pages: 3239-3246

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Human T cells expressing BEND3 on their surface represent a novel subpopulation that preferentially produces IL-6 and IL-8.2014

    • Author(s)
      Shiheido H, Kitagori K, Sasaki C, Kobayashi S, Aoyama T, Urata K, Oku T, Hirayama Y, Yoshitomi H, Hikida M, Yoshifuji H, Mimori T, Watanabe T, Shimizu J.
    • Journal Title

      Immunity, Inflammation and Diseases

      Volume: in press

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Retinoic acid prevents mesenteric lymph node dendritic cells from inducing IL-13-producing inflammatory Th2 cells2013

    • Author(s)
      Yokota-Nakatsuma A, Takeuchi H, Ohoka Y, Kato C, Song SY, Hoshino T, Yagita H, Ohteki T, and Iwata M
    • Journal Title

      Mucosal Immunol

      Volume: 7 Issue: 4 Pages: 786-801

    • DOI

      10.1038/mi.2013.96

    • Related Report
      2014 Annual Research Report 2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] CXCL12 in early mesenchymal progenitors is required for haematopoietic stem-cell maintenance2013

    • Author(s)
      Greenbaum, A., Hsu, Y.M., Day, R.B., Schuettpel,z L.G., Christopher, M.J., Borgerding, J.N., Nagasawa, T., *Link, D.C.
    • Journal Title

      Nature

      Volume: 495 Issue: 7440 Pages: 227-230

    • DOI

      10.1038/nature11926

    • Related Report
      2013 Annual Research Report 2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Germinal center centroblasts transition to a centrocyte phenotype according to a timed program and depend on the dark zone for effective selection2013

    • Author(s)
      Bannard O, Horton RM, Allen CD, An J, Nagasawa T, Cyster JG.
    • Journal Title

      Immunity

      Volume: 39 Issue: 5 Pages: 912-924

    • DOI

      10.1016/j.immuni.2013.08.038

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] The cell polarity protein mInsc regulates neutrophil chemotaxis via a noncanonical G protein signaling pathway2013

    • Author(s)
      Kamakura S., Nomura M., Hayase J., Iwakiri Y., Nishikimi A., Fukui Y., Takayanagi R., Sumimoto H.
    • Journal Title

      Dev Cell

      Volume: 26 Issue: 3 Pages: 292-302

    • DOI

      10.1016/j.devcel.2013.06.008

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Peripheral Nerve-Derived CXCL12 and VEGF-A Regulate the Patterning of Arterial Vessel Branching in Developing Limb Skin2013

    • Author(s)
      Li, W., Kohara, H., Uchida, Y., James, J.M., Soneji, K., Cronshaw, D.G., Zou, Y.R., Nagasawa, T., *Mukouyama, Y.S.
    • Journal Title

      Dev. Cell

      Volume: Dev. Cell Issue: 4 Pages: 359-371

    • DOI

      10.1016/j.devcel.2013.01.009

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Annular PIP3 accumulation controls actin architecture and modulates cytotoxicity at the immunological synapse2013

    • Author(s)
      Le Floc'h A, Tanaka Y, Bantilan NS, Voisinne G, Altan-Bonner G, Fukui Y, Huse M.
    • Journal Title

      J Exp Med

      Volume: 210 Issue: 12 Pages: 2721-2737

    • DOI

      10.1084/jem.20131324

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Neutrophil mobilization via plerixafor-mediated CXCR4 inhibition arises from lung demargination and blockade of neutrophil homing to the bone marrow2013

    • Author(s)
      Devi S, Wang Y, Chew WK, Lima R, A-Gonzalez N, Mattar CN, Chong SZ, Schlitzer A, Bakocevic N, Chew S,
    • Journal Title

      J Exp Med

      Volume: 210 Issue: 11 Pages: 2321-2336

    • DOI

      10.1084/jem.20130056

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Germinal center dysregulation by histone methyltransferase EZH2 promotes lymphomagenesis.2013

    • Author(s)
      Caganova M, Carrisi C, Varano G, Mainoldi F, Zanardi F, Germain PL, George L, Alberghini F, Ferrarini L, Talukder AK, Ponzoni M, Testa G, Nojima T, Doglioni C, Kitamura D,
    • Journal Title

      J Clin Invest

      Volume: 123 Issue: 12 Pages: 5009-5022

    • DOI

      10.1172/jci70626

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Histamine receptor 2 modifies dendritic cell responses to microbial ligands2013

    • Author(s)
      Frei F, Ferstl R, Konieczna P, Ziegler M, Simon T, Rugeles TM, Mailand S, Watanabe T, Lauener R, Akdis C, O’Mahony L.
    • Journal Title

      J Allergy Clin Immunol

      Volume: 132 Issue: 1 Pages: 194-204

    • DOI

      10.1016/j.jaci.2013.01.013

    • Related Report
      2013 Annual Research Report 2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] The Rac activator DOCK2 regulates natural killer cell-mediated cytotoxicity in mice through the lytic synapse formation2013

    • Author(s)
      Sakai Y, Tanaka Y, Yanagihara T, Watanabe M, Duan X, Terasawa M, Nishikimi A, Sanematsu F, Fukui Y.
    • Journal Title

      Blood

      Volume: 122 Issue: 3 Pages: 386-393

    • DOI

      10.1182/blood-2012-12-475897

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] TRAF3 enforces the requirement for T cell cross-talk in thymic medullary epithelial development2013

    • Author(s)
      Jenkinson SR, Williams JA, Jeon H, Zhang J, Nitta T, Ohigashi I, Kruhlak MJ, Zuklys S, Sharrow SO, Adams A, Granger L, Choi Y, Siebenlist U, Bishop GA, Hollander G, Takahama Y, Hodes RJ.
    • Journal Title

      Proc Natl Acad Sci USA

      Volume: 110 Issue: 52 Pages: 21107-21112

    • DOI

      10.1073/pnas.1314859111

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] GATA-1 regulates the generation and function of basophils2013

    • Author(s)
      Nei Y, Obata-Ninomiya K, Tsutsui H, Ishiwata K, Miyasaka M, Matsumoto K, Nakae S, Kanuka H, Inase N, Karasuyama H
    • Journal Title

      Proc Natl Acad Sci USA

      Volume: 110 Issue: 46 Pages: 18620-5

    • DOI

      10.1073/pnas.1311668110

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Rac-specific guanine nucleotide exchange factor DOCK1 is a critical regulator of HER2-mediated breast cancer metastasis2013

    • Author(s)
      Laurin M
    • Journal Title

      Proc. Natl. Acad. Sci. USA

      Volume: 未定 Issue: 18 Pages: 7434-7439

    • DOI

      10.1073/pnas.1213050110

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Interleukin-7 receptor controls development and maturation of late stages of thymocyte subpopulations.2013

    • Author(s)
      Tani-Ichi, S., Shimba, A., Wagatsuma, K., Miyachi, H., Kitano, S., Imai, K., Hara, T., and Ikuta, K.
    • Journal Title

      Proc. Natl. Acad. Sci. U.S.A.

      Volume: 110 Issue: 2 Pages: 612-617

    • DOI

      10.1073/pnas.1219242110

    • NAID

      120005241695

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Aire-expressing thymic medullary epithelial cells originate from β5t-expressing progenitor cells.2013

    • Author(s)
      Ohigashi, I., Zuklys, S., Sakata, M., Mayer, GE., Zhanybekova. S., Murata, S., Tanaka, K., Hollander, G., and Takahama, Y.
    • Journal Title

      Proc Natl Acad Sci USA

      Volume: 110 Issue: 24 Pages: 9885-9890

    • DOI

      10.1073/pnas.1301799110

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] HTLV-1 bZIP Factor Induces Inflammation through Labile Foxp3 Expression.2013

    • Author(s)
      Yamamoto-Taguchi N, Satou Y, Miyazato P, Ohshima K, Nakagawa M, Katagiri K, Kinashi T, Matsuoka M.
    • Journal Title

      PLoS Pathog.

      Volume: 9(9):e1003630. Issue: 9 Pages: 1-12

    • DOI

      10.1371/journal.ppat.1003630

    • NAID

      120005341884

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] A pyrrolo-pyrimidine derivative targets human primary AML stem cells in vivo2013

    • Author(s)
      Saito Y, Yuki H, Kuratani M, Hashizume Y, Takagi S, Honma T, Tanaka A, Shirouzu M, Mikuni J, Handa N, Ogahara I, Sone A, Najima Y, Tomabechi Y,
    • Journal Title

      Sci Transl Med

      Volume: 5 Issue: 181

    • DOI

      10.1126/scitranslmed.3004387

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] B cell progenitors and precursors change their microenvironment in fetal liver during early development.2013

    • Author(s)
      Tsuneto M, Tokoyoda K, Kajikhina E, Hauser AE, Hara T, Tani-ichi S, Ikuta K, Melchers F.
    • Journal Title

      Stem Cells

      Volume: 31 Issue: 12 Pages: 2800-2812

    • DOI

      10.1002/stem.1421

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] A distinct human CD4+ T cell subset that secretes CXCL13 in rheumatoid synovium2013

    • Author(s)
      Kobayashi S, Miura K, Shibuya H, Morita M, Ishikawa M, Furu M, Ito H, Matsuda S, Watanabe T, Yoshitomi H.
    • Journal Title

      Arthritis Rheum

      Volume: 65 Issue: 12 Pages: 3063-3072

    • DOI

      10.1002/art.38173

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Necessity of Lysophosphatidic Acid Receptor 1 for Development of Arthritis2013

    • Author(s)
      Miyabe Y, Miyabe C, Iwai Y, Takayasu A, Fukuda S, Yokoyama W, Nagai J, Jona M, Tokuhara Y, Ohkawa R, Albers HM, Ovaa H, Aoki J, Chun J, Yatomi Y, Ueda H, Miyasaka M, Miyasaka N, Nanki T
    • Journal Title

      Arthritis Rheum

      Volume: 65 Issue: 8 Pages: 2037-2047

    • DOI

      10.1002/art.37991

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] A point mutation in Semaphorin 4A associates with defective endosomal sorting and causes retinal degeneration2013

    • Author(s)
      Nojima S, et al.
    • Journal Title

      Nat Commun

      Volume: 4 Issue: 1 Pages: 1406-1406

    • DOI

      10.1038/ncomms2420

    • Related Report
      2013 Annual Research Report 2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Basophils are required for the induction of Th2 immunity to haptens and peptide antigens.2013

    • Author(s)
      Otsuka A, Nakajima S, Kubo M, Egawa G, Honda T, Kitoh A, Nomura T, Hanakawa S, Sagita Moniaga C, Kim B, Matsuoka S, Watanabe T, Miyachi Y , Kabashima K.
    • Journal Title

      Nature Communications

      Volume: 4 Issue: 1 Pages: 1739-1739

    • DOI

      10.1038/ncomms2740

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Role of macrophage-derived hypoxia-inducible factor (HIF)-1α as a mediator of vascular remodelling2013

    • Author(s)
      Nakayama T, Kurobe H, Sugasawa N, Kinoshita H, Higashida M, Matsuoka Y, Yoshida Y, Hirata Y, Sakata M, Maxfield M, Shimabukuro M, Takahama Y, Sata M, Tamaki T, Kitagawa T, Tomita S.
    • Journal Title

      Cardiovasc Res

      Volume: 99 Issue: 4 Pages: 705-715

    • DOI

      10.1093/cvr/cvt146

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Retinoid X Receptor Agonists Modulate Foxp3 + Regulatory T Cell and Th17 Cell Differentiation with Differential Dependence on Retinoic Acid Receptor Activation.2013

    • Author(s)
      Takeuchi, H.; Yokota-Nakatsuma, A.; Ohoka, Y.; Kagechika, H.; Kato, C.; Si-Young Song, S.-Y.; Iwata, M.
    • Journal Title

      J. Immunol.

      Volume: 191 Issue: 7 Pages: 3725-3733

    • DOI

      10.4049/jimmunol.1300032

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Human CD1c^+ myeloid dendritic cells acquire a high level of retinoic acid-producing capacity in response to vitamin D_32013

    • Author(s)
      Sato T, Kitawaki T, Fujita H, Iwata M, Iyoda T, Inaba K, Ohteki T, Hasegawa S, Kawada K, Sakai Y, Ikeuchi H, Nakase H, Niwa A, Takaori-Kondo A, and Kadowaki N
    • Journal Title

      J Immunol

      Volume: 191(6) Issue: 6 Pages: 3152-3160

    • DOI

      10.4049/jimmunol.1203517

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Dendritic Cells Regulate High-Speed Interstitial T Cell Migration in the Lymph Node via LFA-1/ICAM-1.2013

    • Author(s)
      Katakai T, Habiro K, Kinashi T.
    • Journal Title

      J Immunol

      Volume: 191(3) Issue: 3 Pages: 1188-99

    • DOI

      10.4049/jimmunol.1300739

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Interleukin-7 produced by thymic epithelial cells plays a major role in the development of thymocytes and TCRγδ+ intraepithelial lymphocytes.2013

    • Author(s)
      Shitara S, Hara T, Liang B, Wagatsuma K, Zuklys S, Hollander GA, Nakase H, Chiba T, Tani-ichi S, Ikuta K.
    • Journal Title

      J Immunol

      Volume: 190 Issue: 12 Pages: 6173-6179

    • DOI

      10.4049/jimmunol.1202573

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Lymphotoxin beta receptor regulates the development of CCL21-expressing subset of postnatal medullary thymic epithelial cells2013

    • Author(s)
      Lkhagvasuren E, Sakata M, Ohigashi I, Takahama Y.
    • Journal Title

      J Immunol

      Volume: 190 Issue: 10 Pages: 5110-5117

    • DOI

      10.4049/jimmunol.1203203

    • Related Report
      2013 Annual Research Report 2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Constitutive lymphocyte transmigration across the basal lamina of high endothelial venules is regulated by the autotaxin/lysophosphatidic acid axis2013

    • Author(s)
      Bai Z
    • Journal Title

      J. Immunology

      Volume: 190 Issue: 5 Pages: 2036-2048

    • DOI

      10.4049/jimmunol.1202025

    • Related Report
      2013 Annual Research Report 2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Recirculating memory T cells are a unique subset of CD4+ T cells with a distinct phenotype and migratory pattern.2013

    • Author(s)
      Bromley SK, Yan S, Tomura M, Kanagawa O, Luster AD.
    • Journal Title

      J Immunol

      Volume: 190 Issue: 3 Pages: 970-976

    • DOI

      10.4049/jimmunol.1202805

    • Related Report
      2013 Annual Research Report 2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Phosphatidic acid-dependent recruitment and function of the Rac activator DOCK1 during dorsal ruffle formation.2013

    • Author(s)
      Sanematsu F, Nishikimi A, Watanabe M, Hongu T, Tanaka Y, Kanaho Y, Cote JF, Fukui Y
    • Journal Title

      J. Biol. Chem.

      Volume: 288 Issue: 12 Pages: 8092-8100

    • DOI

      10.1074/jbc.m112.410423

    • Related Report
      2013 Annual Research Report 2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Lysyl 5-Hydroxylation, a Novel Histone Modification, by Jumonji Domain Containing 6 (JMJD6)2013

    • Author(s)
      M. Unoki, A. Masuda, N. Dohmae, K. Arita, M. Yoshimatsu, Y. Iwai, Y. Fukui, K. Ueda, R. Hamamoto, M. Shirakawa, H. Sasaki, and Y. Nakamura
    • Journal Title

      The Journal of biological chemistry

      Volume: 288(9) Issue: 9 Pages: 6053-62

    • DOI

      10.1074/jbc.m112.433284

    • Related Report
      2013 Annual Research Report 2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Dynamic changes in endothelial cell adhesion molecule nepmucin/CD300LG expression under physiological and pathological conditions.2013

    • Author(s)
      Umemoto, E, Takeda, A., Jin, S., Luo, Z., Nakahogi, N., Hayasaka, H., Lee, C.M., Tanaka, T. & Miyasaka, M.
    • Journal Title

      PLoS One

      Volume: 8 Issue: 12 Pages: 1-12

    • DOI

      10.1371/journal.pone.0083681

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Moesin Controls Clathrin-Mediated S1PR1 Internalization in T Cells.2013

    • Author(s)
      Nomachi A, Yoshinaga M, Liu J, Kanchanawong P, Tohyama K, Thumkeo D, Watanabe T, Narumiya S, Hirata T.
    • Journal Title

      PLoS One

      Volume: 8 Issue: 12 Pages: e82590-e82590

    • DOI

      10.1371/journal.pone.0082590

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] DNase γ Is the Effector Endonuclease for Internucleo- somal DNA Fragmentation in Necrosis2013

    • Author(s)
      Mizuta R., Araki S., Furukawa M., Furukawa Y., Ebara S., Shiokawa D., Hayashi K., Tanuma S., and Kitamura D
    • Journal Title

      PLoS One

      Volume: 8(12) Issue: 12 Pages: 1-8

    • DOI

      10.1371/journal.pone.0080223

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Contrasting Quiescent G0 Phase with Mitotic Cell Cycling in the Mouse Immune System.2013

    • Author(s)
      Tomura M, Sakaue-Sawano A, Mori Y, Takase-Utsugi M, Hata A, Ohtawa K, Kanagawa O, Miyawaki A.
    • Journal Title

      Plos One

      Volume: 8 Issue: 9 Pages: e73801-e73801

    • DOI

      10.1371/journal.pone.0073801

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Antigen-specific suppression and immunological synapse formation by regulatory T cells require the mst1 kinase.2013

    • Author(s)
      Tomiyama T, Ueda Y, Katakai T, Kondo N, Okazaki K, Kinashi T.
    • Journal Title

      PLoS One.

      Volume: 8(9):e73874. Issue: 9 Pages: e73874-e73874

    • DOI

      10.1371/journal.pone.0073874

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Cell-autonomous defects in thymic epithelial cells disrupt endothelial-perivascular cell interactions in the mouse thymus2013

    • Author(s)
      Bryson JL, Griffith AV, Hughes B, Saito F, Takahama Y, Richie ER, Manley NR.
    • Journal Title

      PLoS One

      Volume: 8 Issue: 6 Pages: e65196-e65196

    • DOI

      10.1371/journal.pone.0065196

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] CD49b-dependent estabhshment of T helper cell memory.2013

    • Author(s)
      Hanazawa, A., Hayashizaki, K.,Shinoda, K., Yagita, H., Okumura, K., Löhning, M., Hara, T., Tani-ichi, S., Ikuta, K., Eckes, B.,Radbruch, A., Tokoyoda, K, and Nakayama, T.
    • Journal Title

      Immuno1. Cell Bio1

      Volume: 91 Issue: 8 Pages: 524-531

    • DOI

      10.1038/icb.2013.36

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Metameric pattern of intervertebral disc/vertebral body is generated independently of Mesp2/Ripply-mediated rostro-caudal patterning of somites in the mouse embryo.2013

    • Author(s)
      Takahashi Y, Yasuhiko Y, Takahashi J, Takada S, Johnson RL, Saga Y, Kanno J.
    • Journal Title

      Dev Biol.

      Volume: 380 Issue: 2 Pages: 172-184

    • DOI

      10.1016/j.ydbio.2013.05.020

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Signal transducer and activator of transcription 3 (Stat3) contributes to T-cell homeostasis by regulating pro-survival Bcl-2 family genes.2013

    • Author(s)
      Lee JK, Won C, Yi EH, Seok SH, Kim MH, Kim SJ, Chung MH, Lee HG, Ikuta K, Ye SK.
    • Journal Title

      Immunology

      Volume: 140 Issue: 3 Pages: 288-300

    • DOI

      10.1111/imm.12133

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Four-dimensional spatial nanometry of single particles in living cells using polarized quantum rods2013

    • Author(s)
      Watanabe TM, Fujii F, Jin T, Umemoto E, Miyasaka M, Fujita H, Yanagida T.
    • Journal Title

      Biophys J

      Volume: 105 Issue: 3 Pages: 555-564

    • DOI

      10.1016/j.bpj.2013.07.001

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Complete but not partial thymectomy in early infancy reduces T-cell-mediated immune response: three-year tracing study after pediatric cardiac surgery2013

    • Author(s)
      Kurobe H, Tominaga T, Sugano M, Hayabuchi Y, Egawa Y, Takahama Y, Kitagawa T
    • Journal Title

      J Thorac Cardiovasc Surg

      Volume: 143 Issue: 3 Pages: 656-662

    • DOI

      10.1016/j.jtcvs.2012.12.015

    • Related Report
      2013 Annual Research Report 2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Comparative analysis of gamma-delta T cell responses and farnesyl diphosphate synthase inhibition in tumor cells pretreated with zoledronic acid2013

    • Author(s)
      Idrees, AM., Sugie, T., Inoue, C., Murata-Hirai, K., Okamura, H., Morita, CT. Minato, N., Toi, M., Tanaka, Y
    • Journal Title

      Cancer Science

      Volume: (印刷中) Issue: 5 Pages: 536-542

    • DOI

      10.1111/cas.12124

    • Related Report
      2013 Annual Research Report 2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Lymphocyte-stromal cell interaction induces IL-7 expression by interferon regulatory factors.2013

    • Author(s)
      Sekai M, Tani-ichi S, Yoneyama M, Fujita T, Kina T, Ikuta K.
    • Journal Title

      Mol Immunol

      Volume: 54 Issue: 3-4 Pages: 378-385

    • DOI

      10.1016/j.molimm.2013.01.002

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] A multi-purpose fusion tag derived from an unstructured and hyper-acidic region of the amyloid precursor protein.2013

    • Author(s)
      Sangawa, T., Tabata, S., Suzuki, K., Saeki, Y., Tanaka, K., and Takagi, J.
    • Journal Title

      Protein Science

      Volume: 22 Issue: 6 Pages: 840-850

    • DOI

      10.1002/pro.2254

    • Related Report
      2013 Annual Research Report 2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Ablation of the microglial protein DOCK2 reduces amyloid burden in a mouse model of Alzheimer's disease.2013

    • Author(s)
      Cimino PJ, Yang Y, Li X, Hemingway JF, Cherne MK, Khademi SB, Fukui Y, Montine KS, Montine TJ, Keene CD
    • Journal Title

      Exp. Mol. Pathol.

      Volume: 94 Issue: 2 Pages: 366-371

    • DOI

      10.1016/j.yexmp.2013.01.002

    • Related Report
      2013 Annual Research Report 2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Functional cooperation of spns2 and fibronectin in cardiac and lower jaw development2013

    • Author(s)
      Yu Hisano, Satoshi Ota, Shinji Takada and Atsuo Kawahara
    • Journal Title

      Biology Open

      Volume: 2 Issue: 8 Pages: 789-794

    • DOI

      10.1242/bio.20134994

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Basophils are required for the induction of Th2 immunity to haptens and peptide antigens2013

    • Author(s)
      Otsuka A
    • Journal Title

      Nature Comm

      Volume: -

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Systemic circulation and bone recruitment of osteoclast precursors tracked by using fluorescent imaging techniques2013

    • Author(s)
      Kotani M
    • Journal Title

      J Immunol

      Volume: 190 Pages: 605-612

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Optimizing fluorescence excitation and detection for intravital two-photon microscopy2013

    • Author(s)
      Suan D
    • Journal Title

      Methods Cell Biol

      Volume: 113 Pages: 311-323

    • DOI

      10.1016/b978-0-12-407239-8.00014-8

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Analysis of cell movement between skin and other anatomical sites in vivo using photoconvertible fluorescent protein "Kaede"-transgenic mice2013

    • Author(s)
      Tomura M and Kabashima K
    • Journal Title

      Methods Mol Biol

      Volume: 961 Pages: 279-286

    • DOI

      10.1007/978-1-62703-227-8_18

    • ISBN
      9781627032261, 9781627032278
    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] The development of T lymphocytes in fetal thymus organ culture2013

    • Author(s)
      Nitta T
    • Journal Title

      Methods Mol Biol

      Volume: 946 Pages: 85-102

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Zoledronic acid-induced expansion of γ δT cells from early-stage breast cancer patients : effect of IL-18 on helper NK cells2013

    • Author(s)
      Sugie, T., Murata-Hirai, K., Iwasaki, M., Morita, C. T., Li, W., Okamura, H., Minato, N., Toi, M., Tanaka, Y.
    • Journal Title

      Cancer Immunol. Immunoth

      Volume: (印刷中) Issue: 4 Pages: 677-87

    • DOI

      10.1007/s00262-012-1368-4

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Recent advances in intravital imaging of dynamic biological systems.2012

    • Author(s)
      菊田 順一
    • Journal Title

      Journal of Pharmacological Sciences

      Volume: vol.119 Issue: 2 Pages: 193-197

    • DOI

      10.4049/jimmunol.1201345

    • NAID

      10030986703

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Reconstitution of mouse spermatogonial stem cell niches in culture2012

    • Author(s)
      Kanatsu-Shinohara, M., Inoue, K., Takashima, S.,Takehashi, M.,Ogonuki, N., Morimoto, H., Nagasawa, T., Ogura, A. and Shinohara, T
    • Journal Title

      Cell Stem Cell

      Volume: 11(4) Issue: 4 Pages: 567-578

    • DOI

      10.1016/j.stem.2012.06.011

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Il2rg gene-targeted severe combined immunodeficiency pigs2012

    • Author(s)
      Suzuki S, Iwamoto M, Saito Y, Fuchimoto D, Sembon S, Suzuki M, Mikawa S, Hashimoto M, Aoki Y, Najima Y, Takagi S, Suzuki N, Suzuki E, Kubo M, Mimuro J, Kashiwakura Y, Madoiwa S, et al.
    • Journal Title

      Cell Stem Cell

      Volume: 10 Issue: 6 Pages: 753-758

    • DOI

      10.1016/j.stem.2012.04.021

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Rank signaling links the development of invariant γδ T cell progenitors and Aire+ medullary epithelium2012

    • Author(s)
      Roberts NM, White AJ, Jenkinson WE, Turchinovich G, Nakamura K, Withers DR, McConnell FM, Desanti GE, Benezech C, Parnell SM, Cunningham AF, Paolino M, Penninger J, Simon K, Nitta T, Ohigashi I, Takahama Y, Caamano JH, Hayday AC, Lane PJ, Jenkinson EJ, Anderson G
    • Journal Title

      Immunity

      Volume: 36 Issue: 3 Pages: 427-437

    • DOI

      10.1016/j.immuni.2012.01.016

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Trans-mesenteric neural crest cells are the principal source of the colonic enteric nervous system.2012

    • Author(s)
      Nishiyama, C., Uesaka, T., Manabe, T., Yonekura, Y., Nagasawa, T., Newgreen, D.F., Young, H.M., *Enomoto, H.
    • Journal Title

      Nat. Neurosci.

      Volume: 15(9) Issue: 9 Pages: 1211-1218

    • DOI

      10.1038/nn.3184

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Langerhans cells are critical in epicutaneous sensitization with protein antigen via thymic stromal lymphopoietin2012

    • Author(s)
      中島沙恵子、椛島健治, 他
    • Journal Title

      The journal of allergy and clinical immunology

      Volume: 129 Issue: 4 Pages: 1048-1055

    • DOI

      10.1016/j.jaci.2012.01.063

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Crystal structure of α5β1 integrin ectodomain : Atomic details of the fibronectin receptor2012

    • Author(s)
      Nagae, M., et al.
    • Journal Title

      The Journal of Cell Biology

      Volume: 197 Issue: 1 Pages: 131-140

    • DOI

      10.1083/jcb.201111077

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Spi-B is critical for plasmacytoid dendritic cell function and development2012

    • Author(s)
      Sasaki, K. Hoshino, T. Sugiyama, C. Yamazaki, T. Yano, A. Iizuka, H. Hemmi, T. Tanaka, M. Saito, M. Sugiyama, Y. Fukuda, T. Ohta, K. Sato, A. Ainai, T. Suzuki, H. Hasegawa, N. Toyama-Sorimachi, H. Kohara, T. Nagasawa, T. Kaisho
    • Journal Title

      Blood

      Volume: 120 Issue: 24 Pages: 4733-4743

    • DOI

      10.1182/blood-2012-06-436527

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Extracellul- ar matrix protein Tenascin-C is req- uired in the bone marrow microenvio- nment primed for hematopoietic rege- neration2012

    • Author(s)
      Nakamura-Ishizu A, Okuno Y, Omatsu Y, Okabe K, Morimoto J, Uede T, Nagasa- wa T, Suda T, Kubota Y
    • Journal Title

      Blood

      Volume: 119 Issue: 23 Pages: 5429-5437

    • DOI

      10.1182/blood-2011-11-393645

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] DOCK8 is a Cdc42 activator critical for interstitial dendritic cell migrataon during immune responses2012

    • Author(s)
      Yosuke Harada, Yoshihiko Tanaka, Masao Terasawa, Markus Pieczyk, Katsuyoshi Habiro, Tomoya Katakai, Kyoko Hanawa-Suetsugu, Mutsuko Kukimoto-Niino, Tomoko Nishizaki, Mikako Shirouzu, Xuefeng Duan, Takehito Uruno, Akihiko Nishikimi, Fumiyuki Sanematsu, Shigeyuki Yokoyama, Jens V.Stein, Tatsuo Kinashi, Yoshinori Fukui
    • Journal Title

      Blood

      Volume: (In press) Issue: 19 Pages: 4451-4461

    • DOI

      10.1182/blood-2012-01-407098

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Membrane-bound human SCF/KL promotes in vivo human hematopoietic engraftment and myeloid differentiation.2012

    • Author(s)
      Takagi, S
    • Journal Title

      Blood

      Volume: 119 Issue: 12 Pages: 2768-2777

    • DOI

      10.1182/blood-2011-05-353201

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Crystal structure of Enpp1, an extracellular glycoprotein involved in bone mineralization and insulin signaling2012

    • Author(s)
      Kato K, Nishimasu H, Okudaira S, Mihara E, Ishitani R, Takagi J, Aoki J, Nureki O
    • Journal Title

      Proc. Natl Acad. Sci. U. S. A.

      Volume: 109 Issue: 42 Pages: 16876-16881

    • DOI

      10.1073/pnas.1208017109

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Structural basis for mutual relief of the Rac guanine nucleotide exchange factor DOCK2 and its partner ELMO1 from their autoinhibited forms.2012

    • Author(s)
      Hanawa-Suetsugu K, Kukimoto-Niino M, Mishima-Tsumagari C, Akasaka R, Ohsawa N, Sekine S, Ito T, Tochio N, Koshiba S, Kigawa T, Terada T, Shirouzu M, Nishikimi A, Uruno T, Katakai T, Kinashi T, Kohda D, Fukui Y, Yokoyama S
    • Journal Title

      Proc. Natl. Acad. Sci. USA

      Volume: 109 Issue: 9 Pages: 3305-3310

    • DOI

      10.1073/pnas.1113512109

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Thymic nurse cells provide microenvironment for secondary TCRα rearrangement in cortical thymocytes2012

    • Author(s)
      Nakagawa Y
    • Journal Title

      Proc Natl Acad Sci USA

      Volume: 109 Issue: 50 Pages: 20572-20577

    • DOI

      10.1073/pnas.1213069109

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Mst1 regulates integrin-dependent thymocyte trafficking and antigen-recognition in the thymus.2012

    • Author(s)
      Ueda Y., Katagiri K., Tomiyama T., Yasuda K., Habiro K., Katakai T., Ikehara S., Matsumoto M, Kinashi T.
    • Journal Title

      Nat. Commun.

      Volume: 3 Issue: 1 Pages: 1098-1098

    • DOI

      10.1038/ncomms2105

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Neutralizationof theγ-secretase activity bymonoclonal antibody againstextracellular domain of nicastrin2012

    • Author(s)
      Hayashi I, Takatori S, Urano Y, Miyake Y, Takagi J, Sakata-Yanagimoto M, Iwanari H, Osawa S, Morohashi Y, Li T, Wong PC, Chiba S, Kodama T, Hamakubo T, Tomita T, Iwatsubo T
    • Journal Title

      Oncogene

      Volume: 31 Issue: 6 Pages: 787-79

    • DOI

      10.1038/onc.2011.265

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Schwann cell myelination requires integration of laminin activities2012

    • Author(s)
      Karen K. McKee
    • Journal Title

      Journal of Cell Science

      Volume: 125 Pages: 4609-4619

    • DOI

      10.1242/jcs.107995

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Loss of Porcupine impairs convergent extension during gastrulation in zebrafish2012

    • Author(s)
      Chen, Q Takada, R., ^*Takada' S.
    • Journal Title

      J. Cell Sci.

      Volume: 125 Pages: 2224-2234

    • DOI

      10.1242/jcs.098368

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Blockade of inflammatory responses by a small-molecule inhibitor of the Rac activatorDOCK22012

    • Author(s)
      Nishikimi A, Uruno T, Duan X, Cao Q, Okamura Y, Saitoh T, Saitoh N, Sakaoka S, Du Y, Suenaga A, Kukimoto-Niino M, Miyano K, Gotoh K, Okabe T, Sanematsu F, Tanaka Y, Sumimoto H., Honma T, Yokoyama S, Nagano T, Kohda D, Kanai M, and Fukui Y
    • Journal Title

      Chem. Biol

      Volume: 19 Issue: 4 Pages: 488-497

    • DOI

      10.1016/j.chembiol.2012.03.008

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] miRNAs control the maintenance of thymic epithelia and their competence for T lineage committment and thymocyte selection2012

    • Author(s)
      Zuklys S
    • Journal Title

      J Immunol

      Volume: 189 Issue: 8 Pages: 3894-3904

    • DOI

      10.4049/jimmunol.1200783

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] The Endothelial Antigen ESAM Monitors Hematopoietic Stem Cell Status between Quiescence and Self-Renewal.2012

    • Author(s)
      Sudo, T.
    • Journal Title

      J. Immunol.

      Volume: 189 Issue: 1 Pages: 200-210

    • DOI

      10.4049/jimmunol.1200056

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Constitutive Plasmacytoid Dendritic Cell Migration to the Splenic White Pulp Is Cooperatively Regulated by CCR7- and CXCR4-Mediated Signaling.2012

    • Author(s)
      Umemoto, E.
    • Journal Title

      J. Immunol.

      Volume: 189 Issue: 1 Pages: 191-199

    • DOI

      10.4049/jimmunol.1200802

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Development of mature and functional human myeloid subsets in HSC engrafted NOD/SCID/IL2rγKO mice.2012

    • Author(s)
      Tanaka, S
    • Journal Title

      J. Immunol.

      Volume: 188 Issue: 12 Pages: 6145-6155

    • DOI

      10.4049/jimmunol.1103660

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] E2A and CBP/p300 act in synergy to promote chromatin accessibility of the immunoglobulin | locus.2012

    • Author(s)
      Sakamoto, S., ffakae, K., Anzai, Y., Murai, K., Tamaki, N., Miyazaki, M., Miyazaki, K., Romanow, W. J., Ikawa, T., Kitamura, D., Yanagihira, I., Minato, N., Murre, C., Agata, Y
    • Journal Title

      J. Immunol

      Volume: 188 Issue: 11 Pages: 5547-5560

    • DOI

      10.4049/jimmunol.1002346

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] CCR7-independent transport of skin antigens occurs in the dermis2012

    • Author(s)
      Yoshino, M., Okuyama, K., Murata, A., Tomura, M., and Hayashi, S.I.
    • Journal Title

      Eur. J. Immunol.

      Volume: 42 Issue: 6 Pages: 1459-1467

    • DOI

      10.1002/eji.201142114

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] CCR7 with S1P1 signaling through AP1 for migration of Foxp3+ regulatory T cells controls autoimmune exocrinopathy2012

    • Author(s)
      Ishimaru N
    • Journal Title

      American Journal of Pathology

      Volume: 180 Issue: 1 Pages: 199-208

    • DOI

      10.1016/j.ajpath.2011.09.027

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Real-time interactive two-photon photoconversion of recirculating lymphocytes for discontinuous cell tracking in live adult mice2012

    • Author(s)
      Chtanova T
    • Journal Title

      J Biophotonics

      Volume: -

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Dimerization of DOCK2 is essential for DOCK2-mediated Rac activation and lymphocyte migration2012

    • Author(s)
      Terasawa M, Uruno T, Mori S, Kukimoto-Niino M, Nishikimi A, Sanematsu F, Tanaka Y, Yokoyama S, Fukui Y
    • Journal Title

      PLoS ONE

      Volume: 7 Issue: 9 Pages: e46277-e46277

    • DOI

      10.1371/journal.pone.0046277

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Claudin-4 deficiency results in urothelial hyperplasia and lethal hydronephrosis.2012

    • Author(s)
      Fujita, H., Hamazaki, Y. , Noda, Y., Oshima, M., Minato, N.
    • Journal Title

      PLoS One

      Volume: 7 Issue: 12 Pages: e52272-e52272

    • DOI

      10.1371/journal.pone.0052272

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Development and fibronectin signaling requirements of the zebrafish interrenal vessel.2012

    • Author(s)
      Chiu CH, Chou CW, Takada S, Liu YW.
    • Journal Title

      PLoS One.

      Volume: 7 Issue: 8 Pages: e43040-e43040

    • DOI

      10.1371/journal.pone.0043040

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Stromal cell-derived factor 1 regulates the actin organization of chondrocytes and chondrocyte hypertrophy.2012

    • Author(s)
      Murata, K.
    • Journal Title

      PLoS One.

      Volume: 7 Issue: 5 Pages: 237-44

    • DOI

      10.1371/journal.pone.0037163

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Mesogenin causes embryonic mesoderm progenitors to differentiate during development of zebrafish tail somites2012

    • Author(s)
      Yabe T., ^*Takada' S.
    • Journal Title

      Dev. Biol.

      Volume: 370 Issue: 2 Pages: 213-222

    • DOI

      10.1016/j.ydbio.2012.07.029

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Moesin-deficient mice reveal a non-redundant role for moesin in lymphocyte homeostasis2012

    • Author(s)
      Hirata T., et al
    • Journal Title

      Int Immunol.

      Volume: 24 Issue: 11 Pages: 705

    • DOI

      10.1093/intimm/dxs077

    • URL

      https://pure.teikyo.jp/en/publications/a111f7cf-bfc5-40a3-9022-8915b8375687

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] B cells regulate antibody responses through the medullary remodeling of inflamed lymph nodes2012

    • Author(s)
      Jun Abe, Satoshi Ueha, Hiroyuki Yoneyama, Yusuke Shono, Makoto Kurachi, Akiteru Goto, Masashi Fukayama, Michio Tomura, Kazuhiro Kakimi, and Kouji Matsushima
    • Journal Title

      International Immunology

      Volume: 24 Issue: 1 Pages: 17-27

    • DOI

      10.1093/intimm/dxr089

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Increased susceptibility to severe chronic liver damage in CXCR4 conditional knock-out mice.2012

    • Author(s)
      Tsuchiya A.
    • Journal Title

      Dig. Dis. Sci.

      Volume: 57 Issue: 11 Pages: 2892-2900

    • DOI

      10.1007/s10620-012-2239-8

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Tilt-angle measurement of a sample stage using a capacitive liquid-based inclinometer2012

    • Author(s)
      M.Matoba, et al
    • Journal Title

      J.Electron.Microsc.

      Volume: 61(3) Pages: 193-198

    • DOI

      10.1093/jmicro/dfs034

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Expression, purification, crystallization and preliminary X-ray crystallographic analysis of Enpp12012

    • Author(s)
      Kato K, Nishimasu H, Mihara E, Ishitani R, Takagi J, Aoki J, Nureki O
    • Journal Title

      Acta Crystallogr

      Volume: F68 Issue: 7 Pages: 778-782

    • DOI

      10.1107/s1744309112019306

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Generation and characterization of severe combined immune deficientrats.2012

    • Author(s)
      Mashimo T, Takizawa A, Kobayashi J, Kunihiro Y, Yoshimi K, Ishida S, Tanabe K, Yanagi A, Tachibana A, Hirose J, Yomoda J, Morimoto S, Kuramoto T, Voigt B, Watanabe T, Hiai H, Tateno C, Komatsu K, Serikawa T.
    • Journal Title

      Cell Reports

      Volume: 2(3) Issue: 3 Pages: 685-694

    • DOI

      10.1016/j.celrep.2012.08.009

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Next-generation sequencing coupled with a cell-free display technology for high-throughput production of reliable interactome data2012

    • Author(s)
      Fujimori S
    • Journal Title

      Scientific Reports

      Volume: 2 Issue: 1 Pages: 1-5

    • DOI

      10.1038/srep00691

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Higher-order architecture of cell adhesion mediated by polymorphic synaptic adhesion molecules neurexin and neuroligin2012

    • Author(s)
      Tanaka, H., Miyazaki, N., Matoba, K., Nogi, T., Iwasaki, K., and Takagi, J
    • Journal Title

      Cell Reports

      Volume: 2(1) Issue: 1 Pages: 101-110

    • DOI

      10.1016/j.celrep.2012.06.009

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Thymic epithelial cells: working class heroes for T cell development and repertoire selection2012

    • Author(s)
      Anderson G
    • Journal Title

      Trends Immunol

      Volume: 33 Issue: 6 Pages: 256-263

    • DOI

      10.1016/j.it.2012.03.005

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Beta5t-containing thymoproteasome : specific expression in thymic cortical epithelial cells and role in positive selection of CD8+ T cells2012

    • Author(s)
      Takahama Y
    • Journal Title

      Current Opinion in Immunology

      Volume: 24 Issue: 1 Pages: 92-98

    • DOI

      10.1016/j.coi.2012.01.006

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] XCL1 and XCR1 in the immune system2012

    • Author(s)
      Lei Y
    • Journal Title

      Microbes and Infection

      Volume: 14 Issue: 3 Pages: 262-267

    • DOI

      10.1016/j.micinf.2011.10.003

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Bone marrow niches for hematopoietic stem cells and immune cells.2012

    • Author(s)
      Sugiyama, T.
    • Journal Title

      Inflamm. Allergy Drug Targets

      Volume: 11 Issue: 3 Pages: 201-206

    • DOI

      10.2174/187152812800392689

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Marginal reticular cells: a stromal subset directly descended from the lymphoid tissue organizer.2012

    • Author(s)
      Katakai T.
    • Journal Title

      Front Immunol

      Volume: 3

    • DOI

      10.3389/fimmu.2012.00200

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Presentation] cTEC-dependent positive selection of CD8 T cells2017

    • Author(s)
      Yousuke Takahama
    • Organizer
      KTCC2017: 7th International Workshop of Kyoto T Cell Conference
    • Place of Presentation
      京都大学芝蘭会館(京都府・京都市)
    • Year and Date
      2017-03-15
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Aging of Immunity and Immunity in Aging2017

    • Author(s)
      Nagahiro Minato
    • Organizer
      KTCC2017: 7th International Workshop of Kyoto T Cell Conference
    • Place of Presentation
      京都大学芝蘭会館(京都府・京都市)
    • Year and Date
      2017-03-13
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] How the thymic medulla attracts thymocytes for the establishment of self-tolerance2016

    • Author(s)
      高濱 洋介
    • Organizer
      NCI Thymus Symposium
    • Place of Presentation
      National Institutes of Health(メリーランド州、アメリカ)
    • Year and Date
      2016-12-09
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] カバーレター・レスポンスレターの重要性など2016

    • Author(s)
      宮坂 昌之
    • Organizer
      第45回日本免疫学会学術集会
    • Place of Presentation
      沖縄コンベンションセンター、ラグナガーデンホテル(沖縄県・宜野湾市)
    • Year and Date
      2016-12-07
    • Related Report
      2016 Annual Research Report
  • [Presentation] 免疫細胞の動態を規定する微小環境2016

    • Author(s)
      宮坂 昌之
    • Organizer
      第40回日本リンパ学会総会
    • Place of Presentation
      東京大学伊藤国際学術研究センター(東京都・文京区)
    • Year and Date
      2016-06-24
    • Related Report
      2016 Annual Research Report
  • [Presentation] Emerging Approaches in Leukocyte Trafficking2016

    • Author(s)
      宮坂 昌之
    • Organizer
      The Scandinavian Society for Immunology 2016 Summer School "Recent breakthroughs in immunology - emerging new concepts, approaches and methods"
    • Place of Presentation
      University of Turku(Turku, フィンランド)
    • Year and Date
      2016-05-10
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] T cell development and selection in the thymus2016

    • Author(s)
      高濱洋介
    • Organizer
      13th FIMSA Advanced Immunology Course
    • Place of Presentation
      PGIMER(CHANDIGARH, INDIA)
    • Year and Date
      2016-03-17
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] アレルギー疾患・自己免疫疾患などの発症機構と治療技術2016

    • Author(s)
      宮坂昌之
    • Organizer
      国立研究開発法人日本医療研究開発機構(AMED)革新的先端研究開発支援事業
    • Place of Presentation
      国立研究開発法人日本医療研究開発機構(東京都・千代田区)
    • Year and Date
      2016-02-02
    • Related Report
      2015 Annual Research Report
  • [Presentation] Cell-cell interactions in the thymus2015

    • Author(s)
      高濱洋介
    • Organizer
      6th International Thymic Malignancy Interest Group Annual Meeting
    • Place of Presentation
      Regal International East Asia Hotel(上海・中国)
    • Year and Date
      2015-10-23
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] リンパ節での恒常的リンパ球血管外移動はリゾリン脂質シグナリングにより調節される2015

    • Author(s)
      宮坂昌之
    • Organizer
      第22回国立国際医療研究センター研究所セミナー
    • Place of Presentation
      国立国際医療研究センター(東京都・新宿区)
    • Year and Date
      2015-10-19
    • Related Report
      2015 Annual Research Report
    • Invited
  • [Presentation] Thymus-dependent positive selection of T cells2015

    • Author(s)
      高濱洋介
    • Organizer
      Frontiers in Basic Immunology 2015
    • Place of Presentation
      NIH(MD, アメリカ)
    • Year and Date
      2015-10-08
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Locally produced lysophospholipids direct lymphocyte extravasation2015

    • Author(s)
      宮坂昌之
    • Organizer
      MIKRO Seminars of Infection Biology and Infectious Diseases
    • Place of Presentation
      Turku(フィンランド)
    • Year and Date
      2015-09-30
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] A locally generated motogenic lysophospholipid, LPA, regulates trans-HEV and also interstitial migration of lymphocytes in lymph nodes2015

    • Author(s)
      宮坂昌之
    • Organizer
      Ringberg Symposium, Molecular mechanisms in Leukocyte Traffic
    • Place of Presentation
      Ringberg(ドイツ)
    • Year and Date
      2015-09-13
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] からだを守る免疫のしくみ、そして老化とは?-健康食品の有効性?2015

    • Author(s)
      宮坂昌之
    • Organizer
      第99回信濃木崎夏期大学
    • Place of Presentation
      信州木崎夏期大学(長野県大町市)
    • Year and Date
      2015-08-09
    • Related Report
      2015 Annual Research Report
    • Invited
  • [Presentation] 炎症の慢性化機構の解明と制御2015

    • Author(s)
      宮坂昌之
    • Organizer
      国立研究開発法人科学技術振興機構戦略的創造研究推進事業
    • Place of Presentation
      国立研究開発法人科学技術振興機構(東京都・千代田区)
    • Year and Date
      2015-06-15
    • Related Report
      2015 Annual Research Report
  • [Presentation] Thymic microenvironments that form T cell repertoire2015

    • Author(s)
      高濱洋介
    • Organizer
      3rd Belgrade EFIS Symposium on Immunoregulation
    • Place of Presentation
      Hotel Izvor, Arandjelovac Spa (Belgrade, Serbia)
    • Year and Date
      2015-05-24
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] T cell formation in thymus microenvironments2015

    • Author(s)
      高濱洋介
    • Organizer
      Asia CORD Asian Hematology Association Meeting
    • Place of Presentation
      Sysmex Technop(兵庫県・神戸市)
    • Year and Date
      2015-05-01
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] 炎症の慢性化機構の解明と制御に向けた基盤技術の創出2015

    • Author(s)
      宮坂昌之
    • Organizer
      国立研究開発法人日本医療研究開発機構革新的先端研究開発支援事業(AMED-CREST)
    • Place of Presentation
      国立研究開発法人日本医療研究開発機構(東京都・千代田区)
    • Year and Date
      2015-04-01
    • Related Report
      2015 Annual Research Report
  • [Book] Synthetic Immunology2016

    • Author(s)
      渡邊武、高濱洋介
    • Total Pages
      200
    • Publisher
      Springer Japan
    • Related Report
      2016 Annual Research Report
  • [Book] Chronic Inflammation2016

    • Author(s)
      宮坂昌之
    • Total Pages
      702
    • Publisher
      Springer Japan
    • Related Report
      2016 Annual Research Report
  • [Book] Encyclopedia of Immunobiology2016

    • Author(s)
      宮坂昌之
    • Total Pages
      3126
    • Publisher
      Elsevier
    • Related Report
      2016 Annual Research Report
  • [Remarks] 免疫四次元空間ダイナミクス

    • URL

      http://www.genome.tokushima-u.ac.jp/ion/index.html

    • Related Report
      2016 Annual Research Report 2015 Annual Research Report 2014 Annual Research Report
  • [Remarks] 免疫四次元空間ダイナミクス

    • URL

      http://www.genome.tokushima-u.ac.jp/ion/index.html

    • Related Report
      2013 Annual Research Report
  • [Remarks] 科学研究費補助金新学術領域研究「免疫四次元空間ダイナミクス」

    • URL

      http://www.genome.tokushima-u.ac.jp/ion/index.html

    • Related Report
      2012 Annual Research Report
  • [Funded Workshop] The 3rd International Symposium for MEXT Grant-in-Aid for Scientific Research on Analysis and Synthesis of Multidimensional Immune Organ Network2017

    • Place of Presentation
      京都大学芝蘭会館(京都府・京都市)
    • Year and Date
      2017-03-13
    • Related Report
      2016 Annual Research Report
  • [Funded Workshop] 徳島大学国際免疫学シンポジウム2016

    • Place of Presentation
      徳島大学(徳島県・徳島市)
    • Year and Date
      2016-03-03
    • Related Report
      2015 Annual Research Report
  • [Funded Workshop] 次世代シンポジウム Environment Controlling normal and diseased hematopoietic and immune systems2016

    • Place of Presentation
      理化学研究所横浜キャンパス(神奈川県・横浜市)
    • Year and Date
      2016-03-02
    • Related Report
      2015 Annual Research Report

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Published: 2012-11-27   Modified: 2019-07-29  

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