Analysis and Synthesis of Multidimensional Immune Organ Network

• Project Area: Analysis and synthesis of multi-dimensional immune organ network
• Project/Area Number: 24111001
• Research Category: Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)
• Allocation Type: Single-year Grants
• Review Section: Biological Sciences
• Research Institution: The University of Tokushima
• Principal Investigator: TAKAHAMA Yousuke 徳島大学, 先端酵素学研究所, 教授 (20183858)
• Co-Investigator(Kenkyū-buntansha): 渡邊 武 公益財団法人田附興風会, 医学研究所, 特任研究指導者 (40028684) ; 湊 長博 京都大学, 医学(系)研究科(研究院), 教授 (40137716) ; 宮坂 昌之 大阪大学, その他部局等, 名誉教授 (50064613) ; 高田 慎治 大学共同利用機関法人自然科学研究機構(岡崎共通研究施設), 基礎生物学研究所, 教授 (60206753) ; 福井 宣規 九州大学, 生体防御医学研究所, 教授 (60243961) ; 長澤 丘司 大阪大学, 生命機能研究科, 教授 (80281690) ; 高木 淳一 大阪大学, たんぱく質研究所, 教授 (90212000)
• Project Period (FY): 2012-06-28 – 2017-03-31
• Project Status: Completed (Fiscal Year 2016)
• Budget Amount: ¥34,840,000 (Direct Cost: ¥26,800,000、Indirect Cost: ¥8,040,000); Fiscal Year 2016: ¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000); Fiscal Year 2015: ¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000); Fiscal Year 2014: ¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000); Fiscal Year 2013: ¥9,360,000 (Direct Cost: ¥7,200,000、Indirect Cost: ¥2,160,000); Fiscal Year 2012: ¥11,440,000 (Direct Cost: ¥8,800,000、Indirect Cost: ¥2,640,000)
• Keywords: 免疫学 / ストローマ細胞 / 免疫の場 / リンパ器官 / 免疫空間

Outline of Final Research Achievements

The findings include that (1) Foxc1 is a critical regulator of haematopoietic stem cell niche formation, (2) medullary thymic epithelial stem cells maintain a functional thymus to ensure lifelong central T cell tolerance, (3) TCR affinity for thymoproteasome-dependent positively selecting peptides conditions antigen responsiveness in CD8+ T cells, and (4) fibroblastic reticular cell-derived lysophosphatidic acid regulates T-cell motility within the lymph nodes. It was also found that (5) the transcription factor EPAS1 links DOCK8 deficiency to atopic skin inflammation via IL-31 induction, (6) lysosomal sorting of amyloid-beta by the SORLA receptor is impaired by a familial Alzheimer’s disease mutation, (7) a CD153+CD4+ T follicular cell population with cell-senescence features plays a crucial role in lupus pathogenesis via osteopontin production, and (8) gel-trapped lymphorganogenic chemokines trigger artificial tertiary lymphoid organs and mount adaptive immune responses in vivo.

Research Products

• [Int'l Joint Research] National Institutes of Health/University of California(米国)
• [Int'l Joint Research] University of Oxford(英国)
• [Int'l Joint Research] University of Basel(スイス)
• [Int'l Joint Research] McGill University(カナダ)
• [Int'l Joint Research] Universite Montpellier/Claude Bernard University(フランス)
• [Int'l Joint Research]
• [Int'l Joint Research] National Institutes of Health/University of California(米国)
• [Int'l Joint Research] University of Oxford(英国)
• [Int'l Joint Research] University of Basel(スイス)
• [Int'l Joint Research] McGill University(カナダ)
• [Int'l Joint Research] Universite Montpellier/Claude Bernard University(フランス)
• [Int'l Joint Research]
• [Journal Article] ASB7 regulates spindle dynamics and genome integrity by targeting DDA3 for proteasomal degradation. (2017)
  • Author(s): Uematsu K, Okumura F, Tonogai S, Joo-Okumura A, Alemayehu DH, Nishikimi A, Fukui Y, Nakatsukasa K, Kamura T.
  • Journal Title: J Cell Biol Volume: 215 Pages: 95-106
  • DOI: 10.1083/jcb.201603062
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Mathematical modeling of atopic dermatitis reveals “double switch” mechanisms underlying 4 common disease phenotypes (2017)
  • Author(s): Domínguez-Hüttinger E, Christodoulides P, Miyauchi K, Irvine AD, Okada-Hatakeyama M, Kubo M, Tanaka RJ
  • Journal Title: J Allergy Clin Immunol Pract Volume: -
  • DOI: 10.1016/j.jaci.2016.10.026
  • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
• [Journal Article] IL4 from T follicular helper cells downregulates antitumor immunity. (2017)
  • Author(s): Shirota H, Klinman DM, Ito S, Ito H, Kubo M, Ishioka C.
  • Journal Title: Chemotherapy. Volume: 5 Pages: 262-268
  • DOI: 10.1158/2326-6066.cir-16-0113
  • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
• [Journal Article] Allergen-induced CD4+ T-cell cytokine production within airway mucosal DC-T-cell clusters drives the local recruitment of myeloid effector cells. (2017)
  • Author(s): Veres TZ, Kopcsanyi T, van Panhuys N, Gerner MY, Liu Z, Rantakari P, Dunkel J, Miyasaka M, Salmi M, Jalkanen S, Germain RN.
  • Journal Title: J Immunol. Volume: 198 Pages: 895-907
  • DOI: 10.4049/jimmunol.1601448
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] The transcription factor EPAS1 links DOCK8 deficiency to atopic skin inflammation via IL-31 induction. (2017)
  • Author(s): Yamamura K, Uruno T, Shiraishi A, Tanaka Y, Ushijima M, Nakahara T, Watanabe M, Kido-Nakahara M, Tsuge I, Furue M, Fukui Y.
  • Journal Title: Nat Commun. Volume: 8 Pages: 13946-13946
  • DOI: 10.1038/ncomms13946
  • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
• [Journal Article] Conformational freedom of the LRP6 ectodomain is regulated by N-glycosylation and the binding of the Wnt antagonist Dkk1. (2017)
  • Author(s): Matoba K, Mihara E, Tamura-Kawakami K, Miyazaki N, Maeda S, Hirai H, Thompson S, Iwasaki K, and Takagi J.
  • Journal Title: Cell Reports Volume: 18 Pages: 32-40
  • DOI: 10.1016/j.celrep.2016.12.017
  • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
• [Journal Article] Stromal Cell Subsets Directing Neonatal Spleen Regeneration. (2017)
  • Author(s): Tan JK, Watanabe T.
  • Journal Title: Scientific Reports Volume: 7 Pages: 40401-40401
  • DOI: 10.1038/srep40401
  • NAID: 120005997788
  • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
• [Journal Article] Anti-SIRPα antibodies as a potential new tool for cancer immunotherapy. (2017)
  • Author(s): Yanagita T, Murata Y, Tanaka D, Motegi S, Arai E, Daniwijaya EW, Hazama D, Washio K, Saito Y, Kotani T, Ohnishi H, Oldenborg PA, Verjan Garcia N, Miyasaka M, Ishikawa O, Kanai Y, Komori T, Matozaki T.
  • Journal Title: JCI insight Volume: 2
  • DOI: 10.1172/jci.insight.89140
  • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
• [Journal Article] Foxn1-β5t transcriptional axis controls CD8+ T cell production in the thymus. (2017)
  • Author(s): Uddin, MM., Ohigashi, I., Motosugi, R., Nakayama, T., Sakata, M., Hamazaki, J., Nishito, Y., Rode, I., Tanaka, K., Takemoto, T., Murata, S., and Takahama, Y.
  • Journal Title: Nat. Commun. Volume: 8 Pages: 1-10
  • DOI: 10.1038/ncomms14419
  • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
• [Journal Article] DOCK8 Regulates Macrophage Migration through Cdc42 Activation and LRAP35a Interaction. (2017)
  • Author(s): Shiraishi A, Uruno T, Sanematsu F, Ushijima M, Sakata D, Hara T, Fukui Y.
  • Journal Title: Journal of Biological Chemistry Volume: 292 Pages: 2191-2202
  • DOI: 10.1074/jbc.m116.736306
  • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
• [Journal Article] Amine oxidase activity regulates the development of pulmonary fibrosis. (2017)
  • Author(s): Marttila-Ichihara F, Elima K, Auvinen K, Veres TZ, Rantakari P, Weston C, Miyasaka M, Adams D, Jalkanen S, Salmi M.
  • Journal Title: The FASEB Journal Volume: 印刷中
  • DOI: 10.1096/fj.201600935r
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Generation of diversity in thymic epithelial cells. (2017)
  • Author(s): Takahama Y, Ohigashi I, Baik S, Anderson G.
  • Journal Title: Nature Rev Immunol. Volume: 印刷中 Pages: 295-305
  • DOI: 10.1038/nri.2017.12
  • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
• [Journal Article] Generation of peptides that promote positive selection in the thymus. (2017)
  • Author(s): Takada K, Kondo K, Takahama Y.
  • Journal Title: Journal of Immunology Volume: 198 Pages: 2215-2222
  • DOI: 10.4049/jimmunol.1601862
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Intubation-free in vivo imaging of the tracheal mucosa using two photon microscopy. (2017)
  • Author(s): Veres TZ, Kopcsanyi T, Tirri M, Braun A, Miyasaka M, Germain RN, Jalkanen S, Salmi M.
  • Journal Title: Sci Rep. Volume: 印刷中 Pages: 694-694
  • DOI: 10.1038/s41598-017-00769-6
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Involvement of activation-induced cytidine deaminase in skin cancer development. (2016)
  • Author(s): Nonaka, T., Toda, Y., Hiai, H., Uemura, M., Nakamura, M., Yamamoto, N., Asato, R., Hattori, Y., Bessho, K., Minato, N., Kinoshita, K.
  • Journal Title: Journal of Clinical Investigation Volume: 126 Pages: 1367-1382
  • DOI: 10.1172/jci81522
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Relb acts downstream of medullary thymic epithelial stem cells and is essential for the emergence of RANK+ medullary epithelial progenitors. (2016)
  • Author(s): Baik S, Sekai M, Hamazaki Y, Jenkinson WE, Anderson G.
  • Journal Title: Eur J Immunol Volume: - Pages: 857-62
  • DOI: 10.1002/eji.201546253
  • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
• [Journal Article] Aberrant PD-L1 expression via 3'-UTR disruption in multiple cancers. (2016)
  • Author(s): Kataoka K, et al.
  • Journal Title: Nature Volume: 534 Issue: 7607 Pages: 402-406
  • DOI: 10.1038/nature18294
  • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
• [Journal Article] MEIS1-mediated transactivation of synaptotagmin-like 1 promotes CXCL12/CXCR4 signaling and leukemogenesis. (2016)
  • Author(s): Yokoyama T, Nakatake M, Kuwata T, Couiznet A, Goitsuka R, Tsutsumi S, Aburatani H, Valk PJ, Delwel R, Nakamura T.
  • Journal Title: J. Clin. Invest. Volume: 印刷中 Pages: 1664-1678
  • DOI: 10.1172/jci81516
  • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
• [Journal Article] Thy-1+IL-7+ lymphatic endothelial cells in iBALT provide a survival niche for memory T-helper cells in allergic airway inflammation (2016)
  • Author(s): Shinoda, K., Hirahara, K., Iinuma, T., Ichikawa, T., Suzuki, A. S., Sugaya, K., Tumes, D. J., Yamamoto, H., Hara, T., Tani-ichi, S., Ikuta, K., Okamoto, Y., and Nakayama, T.
  • Journal Title: Proc. Natl. Acad. Sci. USA Volume: 113
  • DOI: 10.1073/pnas.1512600113
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Parallel Regulation of von Hippel-Lindau Disease by pVHL-Mediated Degradation of B-Myb and Hypoxia-Inducible Factor α. (2016)
  • Author(s): Okumura F, Uematsu K, Byrne SD, Hirano M, Joo-Okumura A, Nishikimi A, Shuin T, Fukui Y, Nakatsukasa K, Kamura T.
  • Journal Title: Molecular and cellular Biology Volume: 36 Pages: 1803-17
  • DOI: 10.1128/mcb.00067-16
  • NAID: 120005844088
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Medullary thymic epithelial stem cells: role in thymic epithelial cell maintenance and thymic involution (2016)
  • Author(s): Hamazaki Y, Sekai M, Minato N
  • Journal Title: Immunological Reviews Volume: 271 Pages: 38-55
  • DOI: 10.1111/imr.12412
  • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
• [Journal Article] Development and developmental potential of cortical thymic epithelial cells. (2016)
  • Author(s): Ohigashi I, Kozai M, Takahama Y.
  • Journal Title: Immunol Rev. Volume: 271 Pages: 10-22
  • DOI: 10.1111/imr.12404
  • NAID: 120006727049
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Microenvironmental control of high-speed interstitial T cell migration in the lymph node. (2016)
  • Author(s): Katakai T, Kinashi T.
  • Journal Title: Front Immunol. Volume: 7 Pages: 194-194
  • DOI: 10.3389/fimmu.2016.00194
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Sepsis-Induced Osteoblast Ablation Causes Immunodeficiency (2016)
  • Author(s): Asuka Terashima, Kazuo Okamoto, Tomoki Nakashima, Shizuo Akira, Koichi Ikuta, Hiroshi Takayanagi
  • Journal Title: Immunity Volume: 44 Pages: 1434-1443
  • DOI: 10.1016/j.immuni.2016.05.012
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Hyperactivation of JAK1 tyrosine kinase induces stepwise, progressive pruritic dermatitis (2016)
  • Author(s): Yasuda T, Fukada T, Nishida K, Nakayama M, Matsuda M, Miura I, Dainichi T, Fukuda S, Kabashima K, Nakaoka S, Bin BH, Kubo M, Ohno H, Hasegawa T, Ohara O, Koseki H, Wakana S, Yoshida H
  • Journal Title: J. Clin. Invest. Volume: 126(6) Pages: 2064-2076
  • DOI: 10.1172/jci82887
  • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
• [Journal Article] DOCK2 confers immunity and intestinal colonization resistance to Citrobacter rodentium infection. (2016)
  • Author(s): Liu Z, Man SM, Zhu Q, Vogel P, Frase S, Fukui Y, Kanneganti TD.
  • Journal Title: Sci. Rep. Volume: 6 Pages: 27814-27814
  • DOI: 10.1038/srep27814
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Structure of the plexin ectodomain bound by semaphorin-mimicking antibodies. (2016)
  • Author(s): Suzuki K, Tsunoda H, Omiya R, Matoba K, Baba T, Suzuki S, Segawa H, Kumanogoh A, Iwasaki K, Hattori K, Takagi J.
  • Journal Title: PLoS One Volume: 11
  • DOI: 10.1371/journal.pone.0156719
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Identification of embryonic precursor cells that differentiate into thymic epithelial cells expressing autoimmune regulator. (2016)
  • Author(s): Akiyama N, Takizawa N, Miyauchi M, Yanai H, Tateishi R, Shinzawa M, Yoshinaga R, Kurihara M, Demizu Y, Yasuda H, Yagi S, Wu G, Matsumoto M, Sakamoto R, Yoshida N, Penninger JM, Kobayashi Y, Inoue J, Akiyama T.
  • Journal Title: J Exp Med Volume: 213 Pages: 1441-1458
  • DOI: 10.1084/jem.20151780
  • NAID: 120006532434
  • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
• [Journal Article] Heterogeneous fibroblasts underlie age-dependent tertiary lymphoid tissues in the kidney (2016)
  • Author(s): Sato Y, Mii A, Hamazaki Y, Fujita H, Nakata H, Masuda K, Nishiyama S, Shibuya S, Haga H, Ogawa O, Shimizu A, Narumiya S, Kaisho T, Arita M, Yanagisawa M, Miyasaka M, Sharma K, Minato N, Kawamoto H, and Yanagita M.
  • Journal Title: JCI insight Volume: 1
  • DOI: 10.1172/jci.insight.87680
  • NAID: 120005820865
  • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
• [Journal Article] Gel-trapped lymphorganogenic chemokines trigger artificial tertiary lymphoid organs and mount adaptive immune responses in vivo. (2016)
  • Author(s): Kobayashi Y, Watanabe T.
  • Journal Title: Frontiers in Immunology Volume: 7 Pages: 316-316
  • DOI: 10.3389/fimmu.2016.00316
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Gene expression profiling of different arms of lymphatic vasculature identifies new candidates for manipulation of cell traffic. (2016)
  • Author(s): Iftakhar-E-Khuda I, Fair-Makela R, Kukkonen-Macchi A, Elima K, Karikoski M, Rantakari P, Miyasaka M, Salmi M, Jalkanen S.
  • Journal Title: Proc Natl Acad Sci USA. Volume: 113 Pages: 10643-10648
  • DOI: 10.1073/pnas.1602357113
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Probing conformational and functional states of human hepatocyte growth factor by a panel of monoclonal antibodies. (2016)
  • Author(s): Umitsu M, Sakai K, Ogasawara S, Kaneko M, Asaki R, Tamura-Kawakami K, Kato Y, Matsumoto K, Takagi J.
  • Journal Title: Scientific Reports Volume: 9 Pages: 33149-33149
  • DOI: 10.1038/srep33149
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Mice Deficient in Angiopoietin-like Protein 2 (Angptl2) Gene Show Increased Susceptibility to Bacterial Infection Due to Attenuated Macrophage Activity (2016)
  • Author(s): Yugami M, Odagiri H, Endo M, Tsutsuki H, Fujii S, Kadomatsu T, Masuda T, Miyata K, Terada K, Tanoue H, Ito H, Morinaga J, Horiguchi H, Sugizaki T, Akaike T, Gotoh T, Takai T, Sawa T, Mizuta H, Oike Y
  • Journal Title: The Journal of Biological Chemistry Volume: 291 Pages: 18843-18852
  • DOI: 10.1074/jbc.m116.720870
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Structural basis for multi-specific peptide recognition by the anti-IDH1/2 monoclonal antibody, MsMab-1. (2016)
  • Author(s): Kitago Y, Kaneko MK, Ogasawara S, Kato Y, Takagi J.
  • Journal Title: Biochemical and Biophysical Research Communications Volume: 478 Pages: 1274-1279
  • DOI: 10.1016/j.bbrc.2016.08.110
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Protective neutralizing influenza antibody response in the absence of T follicular helper cells (2016)
  • Author(s): Miyauchi K, Sugimoto-Ishige A, Harada Y, Adachi Y, Usami Y, Kaji T, Inoue K, Hasegawa H, Watanabe T, Hijikata A, Fukuyama S, Maemura T, Okada-Hatakeyama M, Ohara O, Kawaoka Y, Takahashi Y, Takemori T, Kubo M
  • Journal Title: Nat Immunol Volume: 17(12) Pages: 1447-1458
  • DOI: 10.1038/ni.3563
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Fibroblastic reticular cells regulate intestinal inflammation through IL-15-mediated control of group 1 ILCs (2016)
  • Author(s): Gil-Cruz, C., Perez-Shibayama, C., Onder, L., Chai, Q., Cupovic, J., Cheng, H., Novkovic, M., Lang, P. A., Geuking, M. B., McCoy, K. D., Abe, S., Cui, G., Ikuta, K., Scandella, E., and Ludewig, B.
  • Journal Title: Nat Immunol Volume: 17 Pages: 1388-1396
  • DOI: 10.1038/ni.3566
  • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
• [Journal Article] Redox-assisted regulation of Ca2+ homeostasis in the endoplasmic reticulum by disulfide reductase ERdj5 (2016)
  • Author(s): R. Ushioda, A. Miyamotod, M. Inoue, S. Watanabe, M. Okumurae, K. Maegawa, K. Uegaki, S. Fujii, Y. Fukuda, M. Umitsu, J. Takagi, K. Inaba, K. Mikoshibad, and K. Nagata
  • Journal Title: Proc. Natl. Acad. Sci. USA Volume: 113(41) Pages: 6055-6063
  • DOI: 10.1073/pnas.1605818113
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Three-dimensional localization of T-cell receptors in relation to microvilli using a combination of super-resolution microscopies. (2016)
  • Author(s): Jung Y, Riven I, Feigelson SW, Kartvelishvily E, Tohya K, Miyasaka M, Alon R, Haran G.
  • Journal Title: Proc Natl Acad Sci USA. Volume: 113
  • DOI: 10.1073/pnas.1605399113
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Upregulation of ANGPTL6 in mouse keratinocytes enhances susceptibility to psoriasis. (2016)
  • Author(s): Tanigawa H, Miyata K, Tian Z, Aoi J, Kadomatsu T, Fukushima S, Ogata A, Takeda N, Zhao J, Zhu S, Terada K, Endo M, Morinaga J, Sugizaki T, Sato M, Morioka MS, Manabe I, Mashimo Y, Hata A, Taketomi Y, Yamamoto K, Murakami M, Araki K, Jinnin M, Ihn H, Oike Y
  • Journal Title: Scientific Reports. Volume: 6 Pages: 1-12
  • DOI: 10.1038/srep34690
  • NAID: 120006534970
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Adrenergic control of the adaptive immune response by diurnal lymphocyte recirculation through lymph nodes (2016)
  • Author(s): Suzuki, K., Hayano, Y., Nakai, A., Furuta, F. and Noda, M.
  • Journal Title: Journal of Experimental Medicine Volume: 213 Pages: 2567-2574
  • DOI: 10.1084/jem.20160723
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Allosteric inhibition of a semaphorin 4D receptor plexin B1 by a high-affinity macrocyclic peptide. (2016)
  • Author(s): Matsunaga Y, Bashiruddin NK, Kitago Y, Takagi J, Suga H.
  • Journal Title: Cell Chem. Biol. Volume: 23 Pages: 1341-1350
  • DOI: 10.1016/j.chembiol.2016.09.015
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] Thymocytes in Lyve1-CRE/S1pr1f/f mice accumulate in the thymus due to cell-intrinsic loss of sphingosine-1-phosphate receptor expression. (2016)
  • Author(s): Takeda A, Hossain MS, Rantakari P, Simmons S, Sasaki N, Salmi M, Jalkanen S, Miyasaka M.
  • Journal Title: Front Immunol. Volume: 7 Pages: 489-489
  • DOI: 10.3389/fimmu.2016.00489
  • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
• [Journal Article] Hematopoietic stem cell niches produce lineage-instructive signals to control multipotent progenitor differentiation (2016)
  • Author(s): Gomes, A. C., Hara, T., Lim, V. Y., Herndler-Brandstetter, D., Nevius, E., Sugiyama, T., Tani-ichi, S., Schlenner, S., Richie, E., Rodewald, H., Flavell, R. A., Nagasawa, T., Ikuta, K., and Pereira, J. P.
  • Journal Title: Immunity Volume: 45 Pages: 1219-1231
  • DOI: 10.1016/j.immuni.2016.11.004
  • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
• [Journal Article] Obesity accelerates T-cell senescence in visceral adipose tissue (2016)
  • Author(s): Shirakawa K, Yan X, Shinmura K, Endo J, Kataoka M, Katsumata Y, Yamamoto T, Anzai A, Isobe S, Yoshida N, Itoh H, Manabe I, Sekai M, Hamazaki Y, Fukuda K, Minato N, and Sano M.
  • Journal Title: Journal of Clinical Investigation Volume: 126 Pages: 4626-4639
  • DOI: 10.1172/jci88606
  • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
• [Journal Article] Allergin-1 inhibits TLR2-mediated mast cell activation and suppresses dermatitis (2016)
  • Author(s): Tsurusaki S, Tahara-Hanaoka S, Shibagaki S, Miyake S, Imai M, Shibayama S, Kubo M, Shibuya A
  • Journal Title: Int Immunol Volume: 28(12) Pages: 605-609
  • DOI: 10.1093/intimm/dxw046
  • NAID: 120007135029
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Flow cytometry analysis of thymic epithelial cells and their subpopulation (2016)
  • Author(s): Ohigashi I, Takahama Y
  • Journal Title: Methods Mol Biol Volume: 1323 Pages: 65-73
  • DOI: 10.1007/978-1-4939-2809-5_5
  • Peer Reviewed
• [Journal Article] Thymus epithelium conditions antigen responsiveness in CD8+ T cells (2016)
  • Author(s): Takada, K., Laethem, F-V, m Xing, Y., Akane, K., Suzuki, H., Murata, S., Tanaka, K., Jameson, S. C., Singer, A., and Takahama, Y.
  • Journal Title: Nat Immunol. Volume: 16 Pages: 1069-1076
  • DOI: 10.1038/ni.3237
  • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
• [Journal Article] Small intestinal eosinophils regulate TH17 cells by producing IL-1 receptor antagonist. (2016)
  • Author(s): Sugawara R, Lee E-J, Jang MS, Jeun E-J, Hong C-P, Kim J-H, Park A, Yun CH, Hong S-W, Kim Y-M, Seoh J-Y, Jung YJ, Surh CD, Miyasaka M, Yang B-G, Jang MH
  • Journal Title: J Exp Med. Volume: 213 Pages: 555-567
  • DOI: 10.1084/jem.20141388
  • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
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  • Journal Title: J. Invest. Dermatol. Volume: 134 Pages: 396-404
  • DOI: 10.1038/jid.2013.353
  • Peer Reviewed
• [Journal Article] A structure-based model of substrate discrimination by a non-canonical PDZ tandem in the intramembrane-cleaving protease RseP. (2014)
  • Author(s): 檜作 洋平, 小田 隆, 田畑 早苗, 川上-田村 恵子, 大井 里香, 佐藤 衛, 高木 淳一, 秋山 芳展, 禾 晃和
  • Journal Title: Structure. Volume: 22 Pages: 326-336
  • DOI: 10.1016/j.str.2013.12.003
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] P-Rex1 directly activates RhoG to regulate GPCR-driven Rac signalling and actin polarity in neutrophils. (2014)
  • Author(s): Damoulakis G, Gambardella L, Rossman K, Lawson C, Anderson K, Fukui Y, Welch H, Der C, Stephens L, Hawkins P.
  • Journal Title: J. Cell Sci. Volume: 127 Pages: 2589-2600
  • DOI: 10.1242/jcs.153049
  • Peer Reviewed
• [Journal Article] DOCK2 and DOCK5 act additively in neutrophils to regulate chemotaxis, superoxide production, and extracellular trap formation. (2014)
  • Author(s): Watanabe M, Terasawa M, Miyano K, Yanagihara T, Uruno T, Sanematsu F, Nishikimi A, Cote JF, Sumimoto H, Fukui Y.
  • Journal Title: J Immunol Volume: 193 Pages: 5660-5607
  • DOI: 10.4049/jimmunol.1400885
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Lymph Node Stromal Cells Negatively Regulate Antigen-Specific CD4+ T Cell Responses. (2014)
  • Author(s): Abe J, Shichino S, Ueha S, Hashimoto S, Tomura M, Inagaki Y, Stein JV, Matsushima K.
  • Journal Title: J Immunol Volume: 193 Pages: 1636-1644
  • DOI: 10.4049/jimmunol.1302946
  • Peer Reviewed
• [Journal Article] Gp49B-mediated negative regulation of antibody production by memory and marginal zone B cells. (2014)
  • Author(s): Fukao S, Haniuda K, Nojima T, Takai T, Kitamura D.
  • Journal Title: The Journal of Immunology Volume: 193 Pages: 635-644
  • DOI: 10.4049/jimmunol.1302772
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Murine Spleen Tissue Regeneration from Neonatal Spleen Capsule Requires Lymphotoxine Priming of Stromal Cells. (2014)
  • Author(s): Tan J, Watanabe T.
  • Journal Title: J Immunol. Volume: 193 Pages: 1194-1203
  • DOI: 10.4049/jimmunol.1302115
  • Peer Reviewed
• [Journal Article] Autotaxin Produced by Stromal Cells Promotes LFA-1－Independent and Rho-Dependent Interstitial T Cell Motility (2014)
  • Author(s): Katakai T., Kondo N., Ueda Y., and Kinashi T
  • Journal Title: J. Immunol. Volume: 193 Pages: 617-626
  • DOI: 10.4049/jimmunol.1400565
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] Genomic sequence analysis of the major histocompatibility complex (MHC) class I G/F segment in common marmoset (Callithrix jacchus) (2014)
  • Author(s): Kono A, Brameier M, Roos C, Suzuki S, Shigenari A, Kametani Y, Kitaura K, Matsutani T, Suzuki R, Inoko H, Walter L, Shiina T
  • Journal Title: J. Immunol Volume: 192 Pages: 3239-3246
  • DOI: 10.4049/jimmunol.1302745
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] Thymic medullary epithelium and thymocyte self-tolerance require cooperation between CD28-CD80/86 and CD40-CD40L costimulatory pathways. (2014)
  • Author(s): Williams JA, Zhang J, Jeon H, Nitta T, Ohigashi I, Klug D, Kruhlak MJ, Choudhury B, Sharrow SO, Granger L, Adams A, Eckhaus MA, Jenkinson SR, Richie ER, Gress RE, Takahama Y, Hodes RJ.
  • Journal Title: The Journal of Immunology Volume: 192 Pages: 630-640
  • DOI: 10.4049/jimmunol.1302550
  • Peer Reviewed
• [Journal Article] Tracking and quantification of dendritic cell migration and antigen trafficking between the skin and lymph nodes. (2014)
  • Author(s): Tomura M, Hata A, Matsuoka S, Shand FH, Nakanishi Y, Ikebuchi R, Ueha S, Tsutsui H, Inaba K, Matsushima K, Miyawaki A, Kabashima K, Watanabe T, Kanagawa O.
  • Journal Title: Scientific Reports Volume: 4 Pages: 1-11
  • DOI: 10.1038/srep06030
  • NAID: 120005749847
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] A novel CD3-specific antibody induces immunosuppression via impaired phosphorylation of LAT and PLCγ1 following T-cell stimulation (2014)
  • Author(s): Shiheido H, Aoyama T, Takahashi H, Hanaoka K, Abe T, Nishida E, Chen C, Koga O, Hikida M, Shibagaki Y, Morita A, Nikawa T, Hattori S, Watanabe T, Shimizu J.
  • Journal Title: Eur J Immunol. Volume: in press Pages: 1770-1780
  • DOI: 10.1002/eji.201344146
  • Peer Reviewed
• [Journal Article] Gimap3 and Gimap5 cooperate to maintain T-cell numbers in the mouse (2014)
  • Author(s): Yano K, Carter C, Yoshida N, Abe T, Yamada A, Nitta T, Ishimaru N, Takada K, Butcher GW, Takahama Y.
  • Journal Title: European Journal of Immunology Volume: 44 Pages: 561572-561572
  • DOI: 10.1002/eji.201343750
  • Peer Reviewed
• [Journal Article] Dental pulp dendritic cells migrate to regional lymph nodes (2014)
  • Author(s): Bhingare AC, Ohno T, Tomura M, Zhang C, Aramaki O, Otsuki M, Tagami J, Azuma M
  • Journal Title: J Dent Res Volume: 93 Pages: 288-293
  • DOI: 10.1177/0022034513518223
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] Activation of fibroblast-like synoviocytes derived from rheumatoid arthritis via lysophosphatidic acid - lysophosphatidic acid receptor 1 cascade. (2014)
  • Author(s): Miyabe Y, Miyabe C, Iwai Y, Yokoyama W, Sekine C, Sugimoto K, Harigai M, Miyasaka M, Miyasaka N, Nanki T.
  • Journal Title: Arthritis Res Ther Volume: 16 Pages: 461-461
  • DOI: 10.1186/s13075-014-0461-9
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Meis1 regulates epidermal stem cells and is required for skin tumorigenesis (2014)
  • Author(s): Okumura K, Saito M, Isogai E, Aoto Y, Hachiya T, Sakakibara Y, Katsuragi Y, Hirose S, Kominami R, Goitsuka R, Nakamura T and Wakabayashi Y.
  • Journal Title: PLoS One Volume: 9
  • DOI: 10.1371/journal.pone.0102111
  • Peer Reviewed / Open Access
• [Journal Article] Induction of Macrophage-Like Immunosuppressive Cells from Mouse ES Cells That Contribute to Prolong Allogeneic Graft Survival. (2014)
  • Author(s): Kudo H, Wada H, Sasaki H, Tsuji H, Otsuka R, Baghdadi M, Kojo S, Chikaraishi T, Seino K.
  • Journal Title: PLoS ONE Volume: 9 Pages: 1-9
  • DOI: 10.1371/journal.pone.0111826
  • NAID: 120005540295
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Retinoic acid and GM-CSF coordinately induce retinal dehydrogenase 2 (RALDH2) expression through cooperation between the RAR/RXR complex and Sp1 in dendritic cells (2014)
  • Author(s): Ohoka Y, Yokota-Nakatsuma A, Maeda N, Takeuchi H, and Iwata M
  • Journal Title: PLoS One Volume: 9(5)
  • DOI: 10.1371/journal.pone.0096512
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Modulation of the human T cell response by a novel non-mitogenic anti-CD3 antibody. (2014)
  • Author(s): Shiheido H, Chen C, Hikida M, Watanabe T, Shimizu J.
  • Journal Title: PLoS One Volume: 9
  • DOI: 10.1371/journal.pone.0094324
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] A novel and effective cancer immunotherapy mouse model using antigen-specific B cells selected in vitro. (2014)
  • Author(s): Moutai T, Yamana H, Nojima T and Kitamura D.
  • Journal Title: PLoS One. Volume: 9 Pages: 92732-92732
  • DOI: 10.1371/journal.pone.0092732
  • Peer Reviewed
• [Journal Article] Enteroendocrine cells are specifically marked by cell surface expression of claudin-4 in mouse small intestine (2014)
  • Author(s): Nagatake T, Fujita H, Minato N, Hamazaki Y.
  • Journal Title: PLoS ONE Volume: 9
  • DOI: 10.1371/journal.pone.0090638
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Meis1 is required for the maintenance of postnatal thymic epithelial cells. (2014)
  • Author(s): Hirayama T, Asano Y, Iida H, Watanabe T, Nakamura T, Goitsuka R.
  • Journal Title: PLoS One Volume: 9
  • DOI: 10.1371/journal.pone.0089885
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Differential Function of Themis CABIT Domains during T Cell Development. (2014)
  • Author(s): Okada T, Nitta T, Kaji K, Takashima A, Oda H, Tamehiro N, Goto M, Okamura T, Patrick MS, Suzuki H.
  • Journal Title: PLoS One. Volume: 9
  • DOI: 10.1371/journal.pone.0089115
  • Peer Reviewed
• [Journal Article] Homeodomain transcription factor meis1 is a critical regulator of adult bone marrow hematopoiesis. (2014)
  • Author(s): Ariki R, Morikawa S, Mabuchi Y, Suzuki S, Nakatake M, Yoshioka K, Hidano S, Nakauchi H, Matsuzaki Y, Nakamura T, Goitsuka R.
  • Journal Title: PLOS ONE Volume: 9 Pages: 87646-87646
  • DOI: 10.1371/journal.pone.0087646
  • Peer Reviewed / Open Access
• [Journal Article] Crystal structure of the lamprey variable-lymphocyte receptor C reveals an unusual feature in its N-terminal capping module (2014)
  • Author(s): Kanda R, Sutoh Y, Kasamatsu J, Maenaka K, Kasahara M, Ose T
  • Journal Title: PLoS ONE Volume: 23
  • DOI: 10.1371/journal.pone.0085875
  • Peer Reviewed
• [Journal Article] Decreased proteasomal activity causes photoreceptor degeneration in mice. (2014)
  • Author(s): Ando R, Noda K, Tomaru U, Kamoshita M, Ozawa Y, Notomi S, Hisatomi T, Noda M, Kanda A, Ishibashi T, Kasahara M, Ishida S.
  • Journal Title: Invest. Ophthalmol. Vis. Sci. Volume: 55 Pages: 4682-4690
  • DOI: 10.1167/iovs.13-13272
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] NF-κB RELA-deficient bone marrow macrophages fail to support bone formation and to maintain the hematopoietic niche after lethal irradiation and stem cell transplantation. (2014)
  • Author(s): Mise-Omata S, Alles N, Fukazawa T, Aoki K, Ohya K, Jimi E, Obata Y, Doi T.
  • Journal Title: International Immunology Volume: 26 Pages: 607-618
  • DOI: 10.1093/intimm/dxu062
  • Peer Reviewed
• [Journal Article] NKG2D functions as an activating receptor on natural killer cells in common marmoset (callithrix jacchus). (2014)
  • Author(s): Watanabe M, Kudo Y, Kawano M, Nakayama M, Nakamura K, Kameda M, Ebara M, Sato T, Nakamura M, Omine K, Kametani Y, Suzuki R, Ogasawara K.
  • Journal Title: Int Immunol Volume: 26 Pages: 597-606
  • DOI: 10.1093/intimm/dxu053
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Increased number of Hassall's corpuscles in myasthenia gravis patients with thymic hyperplasia (2014)
  • Author(s): Matsui N, Ohigashi I, Tanaka K, Nagayama Y, Kondo K, Kitagawa T, Yamashita S, Nomura Y, Takahama Y, Kaji R.
  • Journal Title: Journal of Neuroimmunology Volume: 269 Pages: 56-61
  • DOI: 10.1016/j.jneuroim.2014.01.011
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Copy number and sequence variation of leucine-rich repeat modules suggests distinct functional constraints operating on variable lymphocyte receptors expressed by agnathan T cell-like and B cell-like lymphocytes. (2014)
  • Author(s): Sutoh Y, Kasahara M.
  • Journal Title: Immunogenetics Volume: 66 Pages: 403-409
  • DOI: 10.1007/s00251-014-0773-6
  • Peer Reviewed
• [Journal Article] Corticomedullary differentiation and maturational arrest in thymomas. (2014)
  • Author(s): Storbel P, Hartmann E, Rosenwald A, Kalla J, Ott G, Schalke B, Kasahara M, Tomaru U, Marx A.
  • Journal Title: Histopathology. Volume: 64 Pages: 276-278
  • DOI: 10.1111/his.12279
  • Peer Reviewed
• [Journal Article] MICA/B expression in macrophage foam cells infiltrating atherosclerotic plaques. (2014)
  • Author(s): Ikeshita S, Miyatake Y, Otsuka N, Kasahara M.
  • Journal Title: Exp. Mol. Pathol. Volume: 97 Pages: 171-175
  • DOI: 10.1016/j.yexmp.2014.07.002
  • NAID: 120005476102
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Expression of thymoproteasome subunit β5t in type AB thymoma. (2014)
  • Author(s): Yamada Y, Tomaru U, Ishizu A, Kiuchi T, Kasahara M, Matsuno Y.
  • Journal Title: J Clin Pathol Volume: 67 Pages: 276-278
  • DOI: 10.1136/jclinpath-2013-201930
  • Peer Reviewed
• [Journal Article] Gimap3 and Gimap5 cooperate to maintain T-cell numbers in the mouse. (2014)
  • Author(s): Yano K, Carter C, Yoshida N, Abe T, Yamada A, Nitta T, Ishimaru N, Takada K, Butcher GW, Takahama Y.
  • Journal Title: Biochemical and Biophysical Research Communications Volume: 44 Pages: 241247-241247
  • DOI: 10.1016/j.bbrc.2014.05.023
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] Environments of B cell development. (2014)
  • Author(s): Tsuneto M, Kajikhina E, Seiler K, Reimer A, Tornack J, Bouquet C, Simmons S, Knoll M, Wolf I, Tokoyoda K, Hauser A, Hara T, Tani-Ichi S, Ikuta K, Grun J. R, Grutzkau A, Engels N, Wienands J, Yanagisawa Y, Ohnishi K , Melchers F.
  • Journal Title: Immunol. Lett. Volume: 157 Pages: 60-63
  • DOI: 10.1016/j.imlet.2013.11.011
  • Peer Reviewed
• [Journal Article] Generation of a Tlx1(CreER-Venus) knock-in mouse strain for the study of spleen development. (2014)
  • Author(s): Nakahara R, Kawai Y, Oda A, Nishimura M, Murakami A, Azuma T, Kaifu T, Goitsuka, R.
  • Journal Title: Genesis Volume: 52 Pages: 916-23
  • DOI: 10.1002/dvg.22829
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] Differentiation ability of multipotent hematopoietic stem/progenitor cells detected by a porcine specific anti-CD117 monoclonal antibody (2014)
  • Author(s): Ohshima S, Mori S, Shigenari A, Miyamoto A, Takasu M, Imaeda N, Nunomura S, Okayama Y, Tanaka M, Kitagawa H, Kulski JK, Inoko H, Ando A, Kametani Y.
  • Journal Title: BST Volume: 8 Issue: 6 Pages: 308-315
  • DOI: 10.5582/bst.2014.01084
  • NAID: 130005054671
  • ISSN: 1881-7815, 1881-7823
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] Defect of tropomyosin-related kinase B isotype expression in ovarian clear cell adenocarcinoma. (2014)
  • Author(s): Goto Y, Kametani Y, Kikugawa A, Tsuda B, Miyazawa M, Kajiwara H, Terao Y, Takekoshi S, Nakamura N, Takeda S, Mikami M.
  • Journal Title: Biosci Trends. Volume: 8 Pages: 93-100
  • Peer Reviewed
• [Journal Article] PA tag: a versatile protein tagging system using a super high affinity antibody against a dodecapeptide derived from human podoplanin (2014)
  • Author(s): Fujii Y, Kaneko M, Neyazaki M, Nogi T, Kato Y, Takagi J.
  • Journal Title: Protein Purification and Expression Volume: 95 Pages: 240-247
  • DOI: 10.1016/j.pep.2014.01.009
  • Peer Reviewed
• [Journal Article] The Rac-specific exchange factors Dock1 and Dock5 are dispensable for the establishment of the glomerular filtration barrier in vivo. (2014)
  • Author(s): Laurin M, Dumouchel A, Fukui Y, Cote J-F.
  • Journal Title: Small GTPases Volume: 4 Pages: 221-230
  • DOI: 10.4161/sgtp.27430
  • Peer Reviewed
• [Journal Article] Human T cells expressing BEND3 on their surface represent a novel subpopulation that preferentially produces IL-6 and IL-8. (2014)
  • Author(s): Shiheido H, Kitagori K, Sasaki C, Kobayashi S, Aoyama T, Urata K, Oku T, Hirayama Y, Yoshitomi H, Hikida M, Yoshifuji H, Mimori T, Watanabe T, Shimizu J.
  • Journal Title: Immunity,Inflammation and Diseases Volume: 2 Pages: 35-35
  • DOI: 10.1002/iid3.17
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Genomic sequence analysis of the major histocompatibility complex (MHC) class I G/F segment in common marmoset (Callithrix jacchus). (2014)
  • Author(s): Kono A, Brameier M, Roos C, Suzuki S, Shigenari A, Kametani Y, Kitaura K, Suzuki R, Inoko H, Walter L, Shiina T.
  • Journal Title: J Immunol Volume: 192 Pages: 3239-3246
  • Peer Reviewed
• [Journal Article] Human T cells expressing BEND3 on their surface represent a novel subpopulation that preferentially produces IL-6 and IL-8. (2014)
  • Author(s): Shiheido H, Kitagori K, Sasaki C, Kobayashi S, Aoyama T, Urata K, Oku T, Hirayama Y, Yoshitomi H, Hikida M, Yoshifuji H, Mimori T, Watanabe T, Shimizu J.
  • Journal Title: Immunity, Inflammation and Diseases Volume: in press
  • Peer Reviewed
• [Journal Article] GATA-1 regulates the generation and function of basophils (2014)
  • Author(s): Nei Y, Obata-Ninomiya K, Tsutsui H, Ishiwata K, Miyasaka M, Matsumoto K, Nakae S, Kanuka H, Inase N, Karasuyama H
  • Journal Title: Proc. Natl. Acad. Sci. USA. Volume: 110 Pages: 18620-18625
  • DOI: 10.1073/pnas.1311668110
  • Peer Reviewed
• [Journal Article] CXCL12 in early mesenchymal progenitors is required for haematopoietic stem-cell maintenance (2013)
  • Author(s): Greenbaum, A., Hsu, Y.M., Day, R.B., Schuettpel,z L.G., Christopher, M.J., Borgerding, J.N., Nagasawa, T., *Link, D.C.
  • Journal Title: Nature Volume: 495 Pages: 227-230
  • DOI: 10.1038/nature11926
  • Peer Reviewed
• [Journal Article] Germinal center centroblasts transition to a centrocyte phenotype according to a timed program and depend on the dark zone for effective selection (2013)
  • Author(s): Bannard O, Horton RM, Allen CD, An J, Nagasawa T, Cyster JG.
  • Journal Title: Immunity Volume: 39 Pages: 912-924
  • DOI: 10.1016/j.immuni.2013.08.038
  • Peer Reviewed
• [Journal Article] The cell polarity protein mInsc regulates neutrophil chemotaxis via a noncanonical G protein signaling pathway (2013)
  • Author(s): Kamakura S., Nomura M., Hayase J., Iwakiri Y., Nishikimi A., Fukui Y., Takayanagi R., Sumimoto H.
  • Journal Title: Developmental Cell Volume: 26 Pages: 292-302
  • DOI: 10.1016/j.devcel.2013.06.008
  • Peer Reviewed
• [Journal Article] Peripheral Nerve-Derived CXCL12 and VEGF-A Regulate the Patterning of Arterial Vessel Branching in Developing Limb Skin (2013)
  • Author(s): Li, W., Kohara, H., Uchida, Y., James, J.M., Soneji, K., Cronshaw, D.G., Zou, Y.R., Nagasawa, T., *Mukouyama, Y.S.
  • Journal Title: Dev Cell Volume: Dev. Cell Pages: 359-371
  • DOI: 10.1016/j.devcel.2013.01.009
  • Peer Reviewed
• [Journal Article] Annular PIP3 accumulation controls actin architecture and modulates cytotoxicity at the immunological synapse (2013)
  • Author(s): Le Floc'h A, Tanaka Y, Bantilan NS, Voisinne G, Altan-Bonner G, Fukui Y, Huse M.
  • Journal Title: J. Exp. Med. Volume: 210 Pages: 2721-2737
  • DOI: 10.1084/jem.20131324
  • Peer Reviewed
• [Journal Article] Neutrophil mobilization via plerixafor-mediated CXCR4 inhibition arises from lung demargination and blockade of neutrophil homing to the bone marrow (2013)
  • Author(s): Devi S, Wang Y, Chew WK, Lima R, A-Gonzalez N, Mattar CN, Chong SZ, Schlitzer A, Bakocevic N, Chew S,
  • Journal Title: J. Exp. Med. Volume: 210 Pages: 2321-2336
  • DOI: 10.1084/jem.20130056
  • Peer Reviewed
• [Journal Article] Germinal center dysregulation by histone methyltransferase EZH2 promotes lymphomagenesis. (2013)
  • Author(s): Caganova M, Carrisi C, Varano G, Mainoldi F, Zanardi F, Germain PL, George L, Alberghini F, Ferrarini L, Talukder AK, Ponzoni M, Testa G, Nojima T, Doglioni C, Kitamura D,
  • Journal Title: J. Clin. Invest Volume: 123 Pages: 5009-5022
  • DOI: 10.1172/jci70626
  • Peer Reviewed
• [Journal Article] Histamine receptor 2 modifies dendritic cell responses to microbial ligands (2013)
  • Author(s): Frei F, Ferstl R, Konieczna P, Ziegler M, Simon T, Rugeles TM, Mailand S, Watanabe T, Lauener R, Akdis C, O’Mahony L.
  • Journal Title: J. Allergy and Clinical Immunology Volume: 132 Pages: 194-204
  • DOI: 10.1016/j.jaci.2013.01.013
  • Peer Reviewed
• [Journal Article] The Rac activator DOCK2 regulates natural killer cell-mediated cytotoxicity in mice through the lytic synapse formation (2013)
  • Author(s): Sakai Y, Tanaka Y, Yanagihara T, Watanabe M, Duan X, Terasawa M, Nishikimi A, Sanematsu F, Fukui Y.
  • Journal Title: Blood Volume: 122 Pages: 386-393
  • DOI: 10.1182/blood-2012-12-475897
  • Peer Reviewed
• [Journal Article] TRAF3 enforces the requirement for T cell cross-talk in thymic medullary epithelial development (2013)
  • Author(s): Jenkinson SR, Williams JA, Jeon H, Zhang J, Nitta T, Ohigashi I, Kruhlak MJ, Zuklys S, Sharrow SO, Adams A, Granger L, Choi Y, Siebenlist U, Bishop GA, Hollander G, Takahama Y, Hodes RJ.
  • Journal Title: Proceedings of the National Academy of Sciences of the United States of America Volume: 110 Pages: 21107-21112
  • DOI: 10.1073/pnas.1314859111
  • Peer Reviewed
• [Journal Article] Rac-specific guanine nucleotide exchange factor DOCK1 is a critical regulator of HER2-mediated breast cancer metastasis (2013)
  • Author(s): Laurin M
  • Journal Title: Proc Natl Acad Sci USA Volume: 未定 Pages: 7434-7439
  • DOI: 10.1073/pnas.1213050110
  • Peer Reviewed
• [Journal Article] Interleukin-7 receptor controls development and maturation of late stages of thymocyte subpopulations. (2013)
  • Author(s): Tani-Ichi, S., Shimba, A., Wagatsuma, K., Miyachi, H., Kitano, S., Imai, K., Hara, T., and Ikuta, K.
  • Journal Title: Proc Natl Acad Sci USA Volume: 110 Pages: 612-617
  • DOI: 10.1073/pnas.1219242110
  • NAID: 120005241695
  • Peer Reviewed
• [Journal Article] Aire-expressing thymic medullary epithelial cells originate from β5t-expressing progenitor cells. (2013)
  • Author(s): Ohigashi, I., Zuklys, S., Sakata, M., Mayer, GE., Zhanybekova. S., Murata, S., Tanaka, K., Hollander, G., and Takahama, Y.
  • Journal Title: Proceedings of the National Academy of Sciences of the United States of America Volume: 110 Pages: 9885-9890
  • DOI: 10.1073/pnas.1301799110
  • Peer Reviewed
• [Journal Article] HTLV-1 bZIP Factor Induces Inflammation through Labile Foxp3 Expression. (2013)
  • Author(s): Yamamoto-Taguchi N, Satou Y, Miyazato P, Ohshima K, Nakagawa M, Katagiri K, Kinashi T, Matsuoka M.
  • Journal Title: PLoS Pathog Volume: 9(9):e1003630. Pages: 1-12
  • DOI: 10.1371/journal.ppat.1003630
  • NAID: 120005341884
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] A pyrrolo-pyrimidine derivative targets human primary AML stem cells in vivo (2013)
  • Author(s): Saito Y, Yuki H, Kuratani M, Hashizume Y, Takagi S, Honma T, Tanaka A, Shirouzu M, Mikuni J, Handa N, Ogahara I, Sone A, Najima Y, Tomabechi Y,
  • Journal Title: Sci Transl Med Volume: 5
  • DOI: 10.1126/scitranslmed.3004387
  • Peer Reviewed
• [Journal Article] B cell progenitors and precursors change their microenvironment in fetal liver during early development. (2013)
  • Author(s): Tsuneto M, Tokoyoda K, Kajikhina E, Hauser AE, Hara T, Tani-ichi S, Ikuta K, Melchers F.
  • Journal Title: Stem Cells Volume: 31 Pages: 2800-2812
  • DOI: 10.1002/stem.1421
  • Peer Reviewed
• [Journal Article] A distinct human CD4+ T cell subset that secretes CXCL13 in rheumatoid synovium (2013)
  • Author(s): Kobayashi S, Miura K, Shibuya H, Morita M, Ishikawa M, Furu M, Ito H, Matsuda S, Watanabe T, Yoshitomi H.
  • Journal Title: Arthritis and Rheumatism Volume: 65 Pages: 3063-3072
  • DOI: 10.1002/art.38173
  • Peer Reviewed
• [Journal Article] Necessity of Lysophosphatidic Acid Receptor 1 for Development of Arthritis (2013)
  • Author(s): Miyabe Y, Miyabe C, Iwai Y, Takayasu A, Fukuda S, Yokoyama W, Nagai J, Jona M, Tokuhara Y, Ohkawa R, Albers HM, Ovaa H, Aoki J, Chun J, Yatomi Y, Ueda H, Miyasaka M, Miyasaka N, Nanki T
  • Journal Title: Arthritis & Rheumatism Volume: 65 Pages: 2037-2037
  • DOI: 10.1002/art.37991
  • Peer Reviewed
• [Journal Article] A point mutation in Semaphorin 4A associates with defective endosomal sorting and causes retinal degeneration (2013)
  • Author(s): Nojima S, et al.
  • Journal Title: Nature Communications Volume: 4 Pages: 1-10
  • DOI: 10.1038/ncomms2420
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• [Journal Article] Basophils are required for the induction of Th2 immunity to haptens and peptide antigens. (2013)
  • Author(s): Otsuka A, Nakajima S, Kubo M, Egawa G, Honda T, Kitoh A, Nomura T, Hanakawa S, Sagita Moniaga C, Kim B, Matsuoka S, Watanabe T, Miyachi Y , Kabashima K.
  • Journal Title: Nature Communication Volume: 4 Pages: 1738-1738
  • DOI: 10.1038/ncomms2740
  • NAID: 120005244552
  • Peer Reviewed
• [Journal Article] Role of macrophage-derived hypoxia-inducible factor (HIF)-1α as a mediator of vascular remodelling (2013)
  • Author(s): Nakayama T, Kurobe H, Sugasawa N, Kinoshita H, Higashida M, Matsuoka Y, Yoshida Y, Hirata Y, Sakata M, Maxfield M, Shimabukuro M, Takahama Y, Sata M, Tamaki T, Kitagawa T, Tomita S.
  • Journal Title: Cardiovasc Res. Volume: 99 Pages: 705-715
  • DOI: 10.1093/cvr/cvt146
  • Peer Reviewed
• [Journal Article] Retinoid X Receptor Agonists Modulate Foxp3 + Regulatory T Cell and Th17 Cell Differentiation with Differential Dependence on Retinoic Acid Receptor Activation. (2013)
  • Author(s): Takeuchi, H.; Yokota-Nakatsuma, A.; Ohoka, Y.; Kagechika, H.; Kato, C.; Si-Young Song, S.-Y.; Iwata, M.
  • Journal Title: J Immunol. Volume: 191 Pages: 3725-3733
  • DOI: 10.4049/jimmunol.1300032
  • Peer Reviewed
• [Journal Article] Human CD1c^+ myeloid dendritic cells acquire a high level of retinoic acid-producing capacity in response to vitamin D_3 (2013)
  • Author(s): Sato T, Kitawaki T, Fujita H, Iwata M, Iyoda T, Inaba K, Ohteki T, Hasegawa S, Kawada K, Sakai Y, Ikeuchi H, Nakase H, Niwa A, Takaori-Kondo A, and Kadowaki N
  • Journal Title: J Immunol. Volume: 191(6) Pages: 3152-3160
  • DOI: 10.4049/jimmunol.1203517
  • Peer Reviewed
• [Journal Article] Dendritic Cells Regulate High-Speed Interstitial T Cell Migration in the Lymph Node via LFA-1/ICAM-1. (2013)
  • Author(s): Katakai T, Habiro K, Kinashi T.
  • Journal Title: J. Immunol. Volume: 191(3) Pages: 1188-1199
  • DOI: 10.4049/jimmunol.1300739
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• [Journal Article] Interleukin-7 produced by thymic epithelial cells plays a major role in the development of thymocytes and TCRγδ+ intraepithelial lymphocytes. (2013)
  • Author(s): Shitara S, Hara T, Liang B, Wagatsuma K, Zuklys S, Hollander GA, Nakase H, Chiba T, Tani-ichi S, Ikuta K.
  • Journal Title: J. Immunol. Volume: 190 Pages: 6173-6179
  • DOI: 10.4049/jimmunol.1202573
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• [Journal Article] Lymphotoxin beta receptor regulates the development of CCL21-expressing subset of postnatal medullary thymic epithelial cells (2013)
  • Author(s): Lkhagvasuren E, Sakata M, Ohigashi I, Takahama Y.
  • Journal Title: The Journal of Immunology Volume: 190 Pages: 5110-5117
  • DOI: 10.4049/jimmunol.1203203
  • Peer Reviewed
• [Journal Article] Constitutive lymphocyte transmigration across the basal lamina of high endothelial venules is regulated by the autotaxin/lysophosphatidic acid axis (2013)
  • Author(s): Bai Z
  • Journal Title: J Immunol. Volume: 190 Pages: 2036-2048
  • DOI: 10.4049/jimmunol.1202025
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• [Journal Article] Recirculating memory T cells are a unique subset of CD4+ T cells with a distinct phenotype and migratory pattern. (2013)
  • Author(s): Bromley SK, Yan S, Tomura M, Kanagawa O, Luster AD.
  • Journal Title: J. Immunol. Volume: 190 Pages: 970-976
  • DOI: 10.4049/jimmunol.1202805
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• [Journal Article] Recent advances in intravital imaging of dynamic biological systems. (2013)
  • Author(s): 菊田 順一
  • Journal Title: J. Immunol. Volume: vol.119 Pages: 193-197
  • DOI: 10.4049/jimmunol.1201345
  • NAID: 10030986703
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• [Journal Article] Phosphatidic acid-dependent recruitment and function of the Rac activator DOCK1 during dorsal ruffle formation. (2013)
  • Author(s): Sanematsu F, Nishikimi A, Watanabe M, Hongu T, Tanaka Y, Kanaho Y, Cote JF, Fukui Y
  • Journal Title: J Biol Chem. Volume: 288 Pages: 8092-8100
  • DOI: 10.1074/jbc.m112.410423
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• [Journal Article] Lysyl 5-Hydroxylation, a Novel Histone Modification, by Jumonji Domain Containing 6 (JMJD6) (2013)
  • Author(s): M. Unoki, A. Masuda, N. Dohmae, K. Arita, M. Yoshimatsu, Y. Iwai, Y. Fukui, K. Ueda, R. Hamamoto, M. Shirakawa, H. Sasaki, and Y. Nakamura
  • Journal Title: J. Biol. Chem. Volume: 288(9) Pages: 6053-6062
  • DOI: 10.1074/jbc.m112.433284
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• [Journal Article] Dynamic changes in endothelial cell adhesion molecule nepmucin/CD300LG expression under physiological and pathological conditions. (2013)
  • Author(s): Umemoto, E, Takeda, A., Jin, S., Luo, Z., Nakahogi, N., Hayasaka, H., Lee, C.M., Tanaka, T. & Miyasaka, M.
  • Journal Title: PLOS One Volume: 8 Pages: 1-12
  • DOI: 10.1371/journal.pone.0083681
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• [Journal Article] Moesin Controls Clathrin-Mediated S1PR1 Internalization in T Cells. (2013)
  • Author(s): Nomachi A, Yoshinaga M, Liu J, Kanchanawong P, Tohyama K, Thumkeo D, Watanabe T, Narumiya S, Hirata T.
  • Journal Title: PLoS ONE Volume: 8
  • DOI: 10.1371/journal.pone.0082590
  • Peer Reviewed
• [Journal Article] DNase γ Is the Effector Endonuclease for Internucleo- somal DNA Fragmentation in Necrosis (2013)
  • Author(s): Mizuta R., Araki S., Furukawa M., Furukawa Y., Ebara S., Shiokawa D., Hayashi K., Tanuma S., and Kitamura D
  • Journal Title: PLOS ONE Volume: 8(12) Pages: 1-8
  • DOI: 10.1371/journal.pone.0080223
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• [Journal Article] Contrasting Quiescent G0 Phase with Mitotic Cell Cycling in the Mouse Immune System. (2013)
  • Author(s): Tomura M, Sakaue-Sawano A, Mori Y, Takase-Utsugi M, Hata A, Ohtawa K, Kanagawa O, Miyawaki A.
  • Journal Title: PLoS One. Volume: 8
  • DOI: 10.1371/journal.pone.0073801
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• [Journal Article] Antigen-specific suppression and immunological synapse formation by regulatory T cells require the mst1 kinase. (2013)
  • Author(s): Tomiyama T, Ueda Y, Katakai T, Kondo N, Okazaki K, Kinashi T.
  • Journal Title: PLoS One Volume: 8(9):e73874.
  • DOI: 10.1371/journal.pone.0073874
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• [Journal Article] Cell-autonomous defects in thymic epithelial cells disrupt endothelial-perivascular cell interactions in the mouse thymus (2013)
  • Author(s): Bryson JL, Griffith AV, Hughes B, Saito F, Takahama Y, Richie ER, Manley NR.
  • Journal Title: PLoS One Volume: 8
  • DOI: 10.1371/journal.pone.0065196
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• [Journal Article] CD49b-dependent estabhshment of T helper cell memory. (2013)
  • Author(s): Hanazawa, A., Hayashizaki, K.,Shinoda, K., Yagita, H., Okumura, K., Löhning, M., Hara, T., Tani-ichi, S., Ikuta, K., Eckes, B.,Radbruch, A., Tokoyoda, K, and Nakayama, T.
  • Journal Title: Immunol. Cell Biol. Volume: 91 Pages: 524-31
  • DOI: 10.1038/icb.2013.36
  • Peer Reviewed
• [Journal Article] Metameric pattern of intervertebral disc/vertebral body is generated independently of Mesp2/Ripply-mediated rostro-caudal patterning of somites in the mouse embryo. (2013)
  • Author(s): Takahashi Y, Yasuhiko Y, Takahashi J, Takada S, Johnson RL, Saga Y, Kanno J.
  • Journal Title: Dev Biol Volume: 380 Pages: 172-184
  • DOI: 10.1016/j.ydbio.2013.05.020
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• [Journal Article] Signal transducer and activator of transcription 3 (Stat3) contributes to T-cell homeostasis by regulating pro-survival Bcl-2 family genes. (2013)
  • Author(s): Lee JK, Won C, Yi EH, Seok SH, Kim MH, Kim SJ, Chung MH, Lee HG, Ikuta K, Ye SK.
  • Journal Title: Immunol. Volume: 140 Pages: 288-300
  • DOI: 10.1111/imm.12133
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• [Journal Article] Four-dimensional spatial nanometry of single particles in living cells using polarized quantum rods (2013)
  • Author(s): Watanabe TM, Fujii F, Jin T, Umemoto E, Miyasaka M, Fujita H, Yanagida T.
  • Journal Title: Biophys J. Volume: 105 Pages: 555-564
  • DOI: 10.1016/j.bpj.2013.07.001
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• [Journal Article] Complete but not partial thymectomy in early infancy reduces T-cell-mediated immune response: three-year tracing study after pediatric cardiac surgery (2013)
  • Author(s): Kurobe H, Tominaga T, Sugano M, Hayabuchi Y, Egawa Y, Takahama Y, Kitagawa T
  • Journal Title: J Thorac Cardiovasc Surg. Volume: 143 Pages: 656-662
  • DOI: 10.1016/j.jtcvs.2012.12.015
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• [Journal Article] Comparative analysis of gamma-delta T cell responses and farnesyl diphosphate synthase inhibition in tumor cells pretreated with zoledronic acid (2013)
  • Author(s): Idrees, AM., Sugie, T., Inoue, C., Murata-Hirai, K., Okamura, H., Morita, CT. Minato, N., Toi, M., Tanaka, Y
  • Journal Title: Cancer Sci Volume: (印刷中) Pages: 536-42
  • DOI: 10.1111/cas.12124
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• [Journal Article] Lymphocyte-stromal cell interaction induces IL-7 expression by interferon regulatory factors. (2013)
  • Author(s): Sekai M, Tani-ichi S, Yoneyama M, Fujita T, Kina T, Ikuta K.
  • Journal Title: Mol. Immunol. Volume: 54 Pages: 378-385
  • DOI: 10.1016/j.molimm.2013.01.002
  • NAID: 120005242487
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• [Journal Article] A multi-purpose fusion tag derived from an unstructured and hyper-acidic region of the amyloid precursor protein. (2013)
  • Author(s): Sangawa, T., Tabata, S., Suzuki, K., Saeki, Y., Tanaka, K., and Takagi, J.
  • Journal Title: Protein Sci. Volume: 22 Pages: 840-850
  • DOI: 10.1002/pro.2254
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• [Journal Article] Ablation of the microglial protein DOCK2 reduces amyloid burden in a mouse model of Alzheimer's disease. (2013)
  • Author(s): Cimino PJ, Yang Y, Li X, Hemingway JF, Cherne MK, Khademi SB, Fukui Y, Montine KS, Montine TJ, Keene CD
  • Journal Title: Exp Mol Pathol Volume: 94 Pages: 366-371
  • DOI: 10.1016/j.yexmp.2013.01.002
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• [Journal Article] Functional cooperation of spns2 and fibronectin in cardiac and lower jaw development (2013)
  • Author(s): Yu Hisano, Satoshi Ota, Shinji Takada and Atsuo Kawahara
  • Journal Title: Biol Open Volume: 2 Pages: 789-794
  • DOI: 10.1242/bio.20134994
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Basophils are required for the induction of Th2 immunity to haptens and peptide antigens (2013)
  • Author(s): Otsuka A
  • Journal Title: Nature Comm Volume: -
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• [Journal Article] Systemic circulation and bone recruitment of osteoclast precursors tracked by using fluorescent imaging techniques (2013)
  • Author(s): Kotani M
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• [Journal Article] Optimizing fluorescence excitation and detection for intravital two-photon microscopy (2013)
  • Author(s): Suan D
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  • DOI: 10.1016/b978-0-12-407239-8.00014-8
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• [Journal Article] Analysis of cell movement between skin and other anatomical sites in vivo using photoconvertible fluorescent protein "Kaede"-transgenic mice (2013)
  • Author(s): Tomura M and Kabashima K
  • Journal Title: Methods Mol. Biol Volume: 961 Pages: 279-286
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• [Journal Article] The development of T lymphocytes in fetal thymus organ culture (2013)
  • Author(s): Nitta T
  • Journal Title: Methods Mol Biol Volume: 946 Pages: 85-102
  • Peer Reviewed
• [Journal Article] Zoledronic acid-induced expansion of γ δT cells from early-stage breast cancer patients : effect of IL-18 on helper NK cells (2013)
  • Author(s): Sugie, T., Murata-Hirai, K., Iwasaki, M., Morita, C. T., Li, W., Okamura, H., Minato, N., Toi, M., Tanaka, Y.
  • Journal Title: Cancer Immunol Immunother Volume: (印刷中) Pages: 677-687
  • DOI: 10.1007/s00262-012-1368-4
  • Peer Reviewed
• [Journal Article] Reconstitution of mouse spermatogonial stem cell niches in culture (2012)
  • Author(s): Kanatsu-Shinohara, M., Inoue, K., Takashima, S.,Takehashi, M.,Ogonuki, N., Morimoto, H., Nagasawa, T., Ogura, A. and Shinohara, T
  • Journal Title: Cell Stem Cell Volume: 11(4) Pages: 567-578
  • DOI: 10.1016/j.stem.2012.06.011
  • Peer Reviewed
• [Journal Article] Il2rg gene-targeted severe combined immunodeficiency pigs (2012)
  • Author(s): Suzuki S, Iwamoto M, Saito Y, Fuchimoto D, Sembon S, Suzuki M, Mikawa S, Hashimoto M, Aoki Y, Najima Y, Takagi S, Suzuki N, Suzuki E, Kubo M, Mimuro J, Kashiwakura Y, Madoiwa S, et al.
  • Journal Title: Cell Stem Cell Volume: 10 Pages: 753-758
  • DOI: 10.1016/j.stem.2012.04.021
  • Peer Reviewed
• [Journal Article] Rank signaling links the development of invariant γδ T cell progenitors and Aire+ medullary epithelium (2012)
  • Author(s): Roberts NM, White AJ, Jenkinson WE, Turchinovich G, Nakamura K, Withers DR, McConnell FM, Desanti GE, Benezech C, Parnell SM, Cunningham AF, Paolino M, Penninger J, Simon K, Nitta T, Ohigashi I, Takahama Y, Caamano JH, Hayday AC, Lane PJ, Jenkinson EJ, Anderson G
  • Journal Title: Immunity Volume: 36 Pages: 427-437
  • DOI: 10.1016/j.immuni.2012.01.016
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• [Journal Article] Trans-mesenteric neural crest cells are the principal source of the colonic enteric nervous system. (2012)
  • Author(s): Nishiyama, C., Uesaka, T., Manabe, T., Yonekura, Y., Nagasawa, T., Newgreen, D.F., Young, H.M., *Enomoto, H.
  • Journal Title: Nat Neurosci Volume: 15(9) Pages: 1211-1218
  • DOI: 10.1038/nn.3184
  • Peer Reviewed
• [Journal Article] Langerhans cells are critical in epicutaneous sensitization with protein antigen via thymic stromal lymphopoietin (2012)
  • Author(s): 中島沙恵子、椛島健治, 他
  • Journal Title: J Allergy Clin Immunol. Volume: 129 Pages: 1048-1055
  • DOI: 10.1016/j.jaci.2012.01.063
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• [Journal Article] Crystal structure of α5β1 integrin ectodomain : Atomic details of the fibronectin receptor (2012)
  • Author(s): Nagae, M., et al.
  • Journal Title: J Cell Biol Volume: 197 Pages: 131-140
  • DOI: 10.1083/jcb.201111077
  • Peer Reviewed
• [Journal Article] Spi-B is critical for plasmacytoid dendritic cell function and development (2012)
  • Author(s): Sasaki, K. Hoshino, T. Sugiyama, C. Yamazaki, T. Yano, A. Iizuka, H. Hemmi, T. Tanaka, M. Saito, M. Sugiyama, Y. Fukuda, T. Ohta, K. Sato, A. Ainai, T. Suzuki, H. Hasegawa, N. Toyama-Sorimachi, H. Kohara, T. Nagasawa, T. Kaisho
  • Journal Title: Blood. Volume: 120 Pages: 4733-43
  • DOI: 10.1182/blood-2012-06-436527
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• [Journal Article] Extracellul- ar matrix protein Tenascin-C is req- uired in the bone marrow microenvio- nment primed for hematopoietic rege- neration (2012)
  • Author(s): Nakamura-Ishizu A, Okuno Y, Omatsu Y, Okabe K, Morimoto J, Uede T, Nagasa- wa T, Suda T, Kubota Y
  • Journal Title: Blood Volume: 119 Pages: 5429-37
  • DOI: 10.1182/blood-2011-11-393645
  • Peer Reviewed
• [Journal Article] DOCK8 is a Cdc42 activator critical for interstitial dendritic cell migrataon during immune responses (2012)
  • Author(s): Yosuke Harada, Yoshihiko Tanaka, Masao Terasawa, Markus Pieczyk, Katsuyoshi Habiro, Tomoya Katakai, Kyoko Hanawa-Suetsugu, Mutsuko Kukimoto-Niino, Tomoko Nishizaki, Mikako Shirouzu, Xuefeng Duan, Takehito Uruno, Akihiko Nishikimi, Fumiyuki Sanematsu, Shigeyuki Yokoyama, Jens V.Stein, Tatsuo Kinashi, Yoshinori Fukui
  • Journal Title: Blood. Volume: (In press) Pages: 4451-4461
  • DOI: 10.1182/blood-2012-01-407098
  • Peer Reviewed
• [Journal Article] Membrane-bound human SCF/KL promotes in vivo human hematopoietic engraftment and myeloid differentiation. (2012)
  • Author(s): Takagi, S
  • Journal Title: Blood Volume: 119 Pages: 2768-2777
  • DOI: 10.1182/blood-2011-05-353201
  • Peer Reviewed
• [Journal Article] Crystal structure of Enpp1, an extracellular glycoprotein involved in bone mineralization and insulin signaling (2012)
  • Author(s): Kato K, Nishimasu H, Okudaira S, Mihara E, Ishitani R, Takagi J, Aoki J, Nureki O
  • Journal Title: Proc Natl Acad Sci USA Volume: 109 Pages: 16876-16876
  • DOI: 10.1073/pnas.1208017109
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• [Journal Article] Structural basis for mutual relief of the Rac guanine nucleotide exchange factor DOCK2 and its partner ELMO1 from their autoinhibited forms. (2012)
  • Author(s): Hanawa-Suetsugu K, Kukimoto-Niino M, Mishima-Tsumagari C, Akasaka R, Ohsawa N, Sekine S, Ito T, Tochio N, Koshiba S, Kigawa T, Terada T, Shirouzu M, Nishikimi A, Uruno T, Katakai T, Kinashi T, Kohda D, Fukui Y, Yokoyama S
  • Journal Title: Proc Natl Acad Sci USA Volume: 109 Pages: 3305-3310
  • DOI: 10.1073/pnas.1113512109
  • Peer Reviewed
• [Journal Article] Thymic nurse cells provide microenvironment for secondary TCRα rearrangement in cortical thymocytes (2012)
  • Author(s): Nakagawa Y
  • Journal Title: Proceedings of the National Academy of Sciences USA Volume: 109 Pages: 20572-20577
  • DOI: 10.1073/pnas.1213069109
  • Peer Reviewed
• [Journal Article] Mst1 regulates integrin-dependent thymocyte trafficking and antigen-recognition in the thymus. (2012)
  • Author(s): Ueda Y., Katagiri K., Tomiyama T., Yasuda K., Habiro K., Katakai T., Ikehara S., Matsumoto M, Kinashi T.
  • Journal Title: Nat Commun Volume: 3 Pages: 1098-1098
  • DOI: 10.1038/ncomms2105
  • Peer Reviewed
• [Journal Article] Neutralizationof theγ-secretase activity bymonoclonal antibody againstextracellular domain of nicastrin (2012)
  • Author(s): Hayashi I, Takatori S, Urano Y, Miyake Y, Takagi J, Sakata-Yanagimoto M, Iwanari H, Osawa S, Morohashi Y, Li T, Wong PC, Chiba S, Kodama T, Hamakubo T, Tomita T, Iwatsubo T
  • Journal Title: Oncogene. 9 Volume: 31 Pages: 787-79
  • DOI: 10.1038/onc.2011.265
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• [Journal Article] Schwann cell myelination requires integration of laminin activities (2012)
  • Author(s): Karen K. McKee
  • Journal Title: J Cell Sci Volume: 125 Pages: 4609-4619
  • DOI: 10.1242/jcs.107995
  • Peer Reviewed
• [Journal Article] Loss of Porcupine impairs convergent extension during gastrulation in zebrafish (2012)
  • Author(s): Chen, Q Takada, R., ^*Takada' S.
  • Journal Title: J Cell Sci Volume: 125 Pages: 2224-2234
  • DOI: 10.1242/jcs.098368
  • Peer Reviewed
• [Journal Article] Blockade of inflammatory responses by a small-molecule inhibitor of the Rac activatorDOCK2 (2012)
  • Author(s): Nishikimi A, Uruno T, Duan X, Cao Q, Okamura Y, Saitoh T, Saitoh N, Sakaoka S, Du Y, Suenaga A, Kukimoto-Niino M, Miyano K, Gotoh K, Okabe T, Sanematsu F, Tanaka Y, Sumimoto H., Honma T, Yokoyama S, Nagano T, Kohda D, Kanai M, and Fukui Y
  • Journal Title: Chem Biol Volume: 19 Pages: 488-497
  • DOI: 10.1016/j.chembiol.2012.03.008
  • Peer Reviewed
• [Journal Article] miRNAs control the maintenance of thymic epithelia and their competence for T lineage committment and thymocyte selection (2012)
  • Author(s): Zuklys S
  • Journal Title: J Immunol Volume: 189 Pages: 3894-3904
  • DOI: 10.4049/jimmunol.1200783
  • Peer Reviewed
• [Journal Article] The Endothelial Antigen ESAM Monitors Hematopoietic Stem Cell Status between Quiescence and Self-Renewal. (2012)
  • Author(s): Sudo, T.
  • Journal Title: The Journal of Immunology Volume: 189 Pages: 200-210
  • DOI: 10.4049/jimmunol.1200056
  • Peer Reviewed
• [Journal Article] Constitutive Plasmacytoid Dendritic Cell Migration to the Splenic White Pulp Is Cooperatively Regulated by CCR7- and CXCR4-Mediated Signaling. (2012)
  • Author(s): Umemoto, E.
  • Journal Title: Journal of Immunology Volume: 189 Pages: 191-199
  • DOI: 10.4049/jimmunol.1200802
  • Peer Reviewed
• [Journal Article] Development of mature and functional human myeloid subsets in HSC engrafted NOD/SCID/IL2rγKO mice. (2012)
  • Author(s): Tanaka, S
  • Journal Title: J Immunol Volume: 188 Pages: 6145-55
  • DOI: 10.4049/jimmunol.1103660
  • Peer Reviewed
• [Journal Article] E2A and CBP/p300 act in synergy to promote chromatin accessibility of the immunoglobulin | locus. (2012)
  • Author(s): Sakamoto, S., ffakae, K., Anzai, Y., Murai, K., Tamaki, N., Miyazaki, M., Miyazaki, K., Romanow, W. J., Ikawa, T., Kitamura, D., Yanagihira, I., Minato, N., Murre, C., Agata, Y
  • Journal Title: J. Immunol. Volume: 188 Pages: 5547-5560
  • DOI: 10.4049/jimmunol.1002346
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• [Journal Article] CCR7-independent transport of skin antigens occurs in the dermis (2012)
  • Author(s): Yoshino, M., Okuyama, K., Murata, A., Tomura, M., and Hayashi, S.I.
  • Journal Title: Eur J Immunol Volume: 42 Pages: 1459-1467
  • DOI: 10.1002/eji.201142114
  • Peer Reviewed
• [Journal Article] CCR7 with S1P1 signaling through AP1 for migration of Foxp3+ regulatory T cells controls autoimmune exocrinopathy (2012)
  • Author(s): Ishimaru N
  • Journal Title: The American Journal of Pathology Volume: 180 Pages: 199-208
  • DOI: 10.1016/j.ajpath.2011.09.027
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• [Journal Article] Real-time interactive two-photon photoconversion of recirculating lymphocytes for discontinuous cell tracking in live adult mice (2012)
  • Author(s): Chtanova T
  • Journal Title: J Biophotonics Volume: -
  • Peer Reviewed
• [Journal Article] Dimerization of DOCK2 is essential for DOCK2-mediated Rac activation and lymphocyte migration (2012)
  • Author(s): Terasawa M, Uruno T, Mori S, Kukimoto-Niino M, Nishikimi A, Sanematsu F, Tanaka Y, Yokoyama S, Fukui Y
  • Journal Title: PLoS One Volume: 7
  • DOI: 10.1371/journal.pone.0046277
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• [Journal Article] Claudin-4 deficiency results in urothelial hyperplasia and lethal hydronephrosis. (2012)
  • Author(s): Fujita, H., Hamazaki, Y. , Noda, Y., Oshima, M., Minato, N.
  • Journal Title: PLoS One. Volume: 7
  • DOI: 10.1371/journal.pone.0052272
  • Peer Reviewed
• [Journal Article] Development and fibronectin signaling requirements of the zebrafish interrenal vessel. (2012)
  • Author(s): Chiu CH, Chou CW, Takada S, Liu YW.
  • Journal Title: PLoS One Volume: 7
  • DOI: 10.1371/journal.pone.0043040
  • Peer Reviewed
• [Journal Article] Stromal cell-derived factor 1 regulates the actin organization of chondrocytes and chondrocyte hypertrophy. (2012)
  • Author(s): Murata, K.
  • Journal Title: Telemed J E Health. Volume: 7 Pages: 237-44
  • DOI: 10.1371/journal.pone.0037163
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• [Journal Article] Mesogenin causes embryonic mesoderm progenitors to differentiate during development of zebrafish tail somites (2012)
  • Author(s): Yabe T., ^*Takada' S.
  • Journal Title: Dev Biol Volume: 370 Pages: 213-222
  • DOI: 10.1016/j.ydbio.2012.07.029
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• [Journal Article] Moesin-deficient mice reveal a non-redundant role for moesin in lymphocyte homeostasis. (2012)
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  • Journal Title: Int Immunol Volume: 24 Pages: 705-717
  • DOI: 10.1093/intimm/dxs077
  • Peer Reviewed
• [Journal Article] B cells regulate antibody responses through the medullary remodeling of inflamed lymph nodes (2012)
  • Author(s): Jun Abe, Satoshi Ueha, Hiroyuki Yoneyama, Yusuke Shono, Makoto Kurachi, Akiteru Goto, Masashi Fukayama, Michio Tomura, Kazuhiro Kakimi, and Kouji Matsushima
  • Journal Title: Int Immunol Volume: 24 Pages: 17-27
  • DOI: 10.1093/intimm/dxr089
  • Peer Reviewed
• [Journal Article] Increased susceptibility to severe chronic liver damage in CXCR4 conditional knock-out mice. (2012)
  • Author(s): Tsuchiya A.
  • Journal Title: Digestive Diseases and Sciences Volume: 57 Pages: 2892-2900
  • DOI: 10.1007/s10620-012-2239-8
  • Peer Reviewed
• [Journal Article] Tilt-angle measurement of a sample stage using a capacitive liquid-based inclinometer (2012)
  • Author(s): M.Matoba, et al
  • Journal Title: J Electron Microsc (Tokyo) Volume: 61(3) Pages: 193-198
  • DOI: 10.1093/jmicro/dfs034
  • Peer Reviewed
• [Journal Article] Expression, purification, crystallization and preliminary X-ray crystallographic analysis of Enpp1 (2012)
  • Author(s): Kato K, Nishimasu H, Mihara E, Ishitani R, Takagi J, Aoki J, Nureki O
  • Journal Title: Acta Crystallographica Section F Volume: F68 Pages: 778-778
  • DOI: 10.1107/s1744309112019306
  • Peer Reviewed
• [Journal Article] Generation and characterization of severe combined immune deficientrats. (2012)
  • Author(s): Mashimo T, Takizawa A, Kobayashi J, Kunihiro Y, Yoshimi K, Ishida S, Tanabe K, Yanagi A, Tachibana A, Hirose J, Yomoda J, Morimoto S, Kuramoto T, Voigt B, Watanabe T, Hiai H, Tateno C, Komatsu K, Serikawa T.
  • Journal Title: Cell Reports Volume: 2(3) Pages: 685-694
  • DOI: 10.1016/j.celrep.2012.08.009
  • Peer Reviewed
• [Journal Article] Next-generation sequencing coupled with a cell-free display technology for high-throughput production of reliable interactome data (2012)
  • Author(s): Fujimori S
  • Journal Title: Scientific Reports Volume: 2 Pages: 1-5
  • DOI: 10.1038/srep00691
  • Peer Reviewed
• [Journal Article] Higher-order architecture of cell adhesion mediated by polymorphic synaptic adhesion molecules neurexin and neuroligin (2012)
  • Author(s): Tanaka, H., Miyazaki, N., Matoba, K., Nogi, T., Iwasaki, K., and Takagi, J
  • Journal Title: Cell Rep Volume: 2(1) Pages: 101-110
  • DOI: 10.1016/j.celrep.2012.06.009
  • Peer Reviewed
• [Journal Article] Thymic epithelial cells: working class heroes for T cell development and repertoire selection (2012)
  • Author(s): Anderson G
  • Journal Title: Trends Immunol Volume: 33 Pages: 256-263
  • DOI: 10.1016/j.it.2012.03.005
  • Peer Reviewed
• [Journal Article] Beta5t-containing thymoproteasome : specific expression in thymic cortical epithelial cells and role in positive selection of CD8+ T cells (2012)
  • Author(s): Takahama Y
  • Journal Title: Curr Op Immunol Volume: 24 Pages: 9298-9298
  • DOI: 10.1016/j.coi.2012.01.006
  • Peer Reviewed
• [Journal Article] XCL1 and XCR1 in the immune system (2012)
  • Author(s): Lei Y
  • Journal Title: Microbes and Infection Volume: 14 Pages: 262-267
  • DOI: 10.1016/j.micinf.2011.10.003
  • Peer Reviewed
• [Journal Article] Bone marrow niches for hematopoietic stem cells and immune cells. (2012)
  • Author(s): Sugiyama, T.
  • Journal Title: Inflamm Allergy Drug Targets Volume: 11 Pages: 201-206
  • DOI: 10.2174/187152812800392689
  • NAID: 120004287995
  • Peer Reviewed
• [Journal Article] Marginal reticular cells: a stromal subset directly descended from the lymphoid tissue organizer. (2012)
  • Author(s): Katakai T.
  • Journal Title: Front Immunol Volume: 3
  • DOI: 10.3389/fimmu.2012.00200
  • Peer Reviewed
• [Presentation] cTEC-dependent positive selection of CD8 T cells (2017)
  • Author(s): Yousuke Takahama
  • Organizer: KTCC2017: 7th International Workshop of Kyoto T Cell Conference
  • Place of Presentation: 京都大学芝蘭会館（京都府・京都市）
  • Year and Date: 2017-03-15
  • Int'l Joint Research
• [Presentation] Aging of Immunity and Immunity in Aging (2017)
  • Author(s): Nagahiro Minato
  • Organizer: KTCC2017: 7th International Workshop of Kyoto T Cell Conference
  • Place of Presentation: 京都大学芝蘭会館（京都府・京都市）
  • Year and Date: 2017-03-13
  • Int'l Joint Research / Invited
• [Presentation] How the thymic medulla attracts thymocytes for the establishment of self-tolerance (2016)
  • Author(s): 高濱 洋介
  • Organizer: NCI Thymus Symposium
  • Place of Presentation: National Institutes of Health（メリーランド州、アメリカ）
  • Year and Date: 2016-12-09
  • Int'l Joint Research / Invited
• [Presentation] カバーレター・レスポンスレターの重要性など (2016)
  • Author(s): 宮坂 昌之
  • Organizer: 第４５回日本免疫学会学術集会
  • Place of Presentation: 沖縄コンベンションセンター、ラグナガーデンホテル（沖縄県・宜野湾市）
  • Year and Date: 2016-12-07
• [Presentation] 免疫細胞の動態を規定する微小環境 (2016)
  • Author(s): 宮坂 昌之
  • Organizer: 第４０回日本リンパ学会総会
  • Place of Presentation: 東京大学伊藤国際学術研究センター（東京都・文京区）
  • Year and Date: 2016-06-24
• [Presentation] Emerging Approaches in Leukocyte Trafficking (2016)
  • Author(s): 宮坂 昌之
  • Organizer: The Scandinavian Society for Immunology 2016 Summer School "Recent breakthroughs in immunology - emerging new concepts, approaches and methods"
  • Place of Presentation: University of Turku（Turku, フィンランド）
  • Year and Date: 2016-05-10
  • Int'l Joint Research / Invited
• [Presentation] T cell development and selection in the thymus (2016)
  • Author(s): 高濱洋介
  • Organizer: 13th FIMSA Advanced Immunology Course
  • Place of Presentation: PGIMER（CHANDIGARH, INDIA）
  • Year and Date: 2016-03-17
  • Int'l Joint Research / Invited
• [Presentation] アレルギー疾患・自己免疫疾患などの発症機構と治療技術 (2016)
  • Author(s): 宮坂昌之
  • Organizer: 国立研究開発法人日本医療研究開発機構（AMED）革新的先端研究開発支援事業
  • Place of Presentation: 国立研究開発法人日本医療研究開発機構（東京都・千代田区）
  • Year and Date: 2016-02-02
• [Presentation] Cell-cell interactions in the thymus (2015)
  • Author(s): 高濱洋介
  • Organizer: 6th International Thymic Malignancy Interest Group Annual Meeting
  • Place of Presentation: Regal International East Asia Hotel（上海・中国）
  • Year and Date: 2015-10-23
  • Int'l Joint Research / Invited
• [Presentation] リンパ節での恒常的リンパ球血管外移動はリゾリン脂質シグナリングにより調節される (2015)
  • Author(s): 宮坂昌之
  • Organizer: 第22回国立国際医療研究センター研究所セミナー
  • Place of Presentation: 国立国際医療研究センター（東京都・新宿区）
  • Year and Date: 2015-10-19
  • Invited
• [Presentation] Thymus-dependent positive selection of T cells (2015)
  • Author(s): 高濱洋介
  • Organizer: Frontiers in Basic Immunology 2015
  • Place of Presentation: NIH（MD, アメリカ）
  • Year and Date: 2015-10-08
  • Int'l Joint Research / Invited
• [Presentation] Locally produced lysophospholipids direct lymphocyte extravasation (2015)
  • Author(s): 宮坂昌之
  • Organizer: MIKRO Seminars of Infection Biology and Infectious Diseases
  • Place of Presentation: Turku（フィンランド）
  • Year and Date: 2015-09-30
  • Int'l Joint Research / Invited
• [Presentation] A locally generated motogenic lysophospholipid, LPA, regulates trans-HEV and also interstitial migration of lymphocytes in lymph nodes (2015)
  • Author(s): 宮坂昌之
  • Organizer: Ringberg Symposium, Molecular mechanisms in Leukocyte Traffic
  • Place of Presentation: Ringberg（ドイツ）
  • Year and Date: 2015-09-13
  • Int'l Joint Research / Invited
• [Presentation] からだを守る免疫のしくみ、そして老化とは？－健康食品の有効性？ (2015)
  • Author(s): 宮坂昌之
  • Organizer: 第９９回信濃木崎夏期大学
  • Place of Presentation: 信州木崎夏期大学（長野県大町市）
  • Year and Date: 2015-08-09
  • Invited
• [Presentation] 炎症の慢性化機構の解明と制御 (2015)
  • Author(s): 宮坂昌之
  • Organizer: 国立研究開発法人科学技術振興機構戦略的創造研究推進事業
  • Place of Presentation: 国立研究開発法人科学技術振興機構（東京都・千代田区）
  • Year and Date: 2015-06-15
• [Presentation] Thymic microenvironments that form T cell repertoire (2015)
  • Author(s): 高濱洋介
  • Organizer: 3rd Belgrade EFIS Symposium on Immunoregulation
  • Place of Presentation: Hotel Izvor, Arandjelovac Spa (Belgrade, Serbia)
  • Year and Date: 2015-05-24
  • Int'l Joint Research / Invited
• [Presentation] T cell formation in thymus microenvironments (2015)
  • Author(s): 高濱洋介
  • Organizer: Asia CORD Asian Hematology Association Meeting
  • Place of Presentation: Sysmex Technop（兵庫県・神戸市）
  • Year and Date: 2015-05-01
  • Int'l Joint Research / Invited
• [Presentation] 炎症の慢性化機構の解明と制御に向けた基盤技術の創出 (2015)
  • Author(s): 宮坂昌之
  • Organizer: 国立研究開発法人日本医療研究開発機構革新的先端研究開発支援事業（AMED-CREST）
  • Place of Presentation: 国立研究開発法人日本医療研究開発機構（東京都・千代田区）
  • Year and Date: 2015-04-01
• [Book] Synthetic Immunology (2016)
  • Author(s): 渡邊武、高濱洋介
  • Total Pages: 200
  • Publisher: Springer Japan
• [Book] Chronic Inflammation (2016)
  • Author(s): 宮坂昌之
  • Total Pages: 702
  • Publisher: Springer Japan
• [Book] Encyclopedia of Immunobiology (2016)
  • Author(s): 宮坂昌之
  • Total Pages: 3126
  • Publisher: Elsevier
• [Remarks] 免疫四次元空間ダイナミクス
  • URL: http://www.genome.tokushima-u.ac.jp/ion/index.html
• [Remarks] 免疫四次元空間ダイナミクス
  • URL: http://www.genome.tokushima-u.ac.jp/ion/index.html
• [Remarks] 科学研究費補助金新学術領域研究「免疫四次元空間ダイナミクス」
  • URL: http://www.genome.tokushima-u.ac.jp/ion/index.html
• [Funded Workshop] The 3rd International Symposium for MEXT Grant-in-Aid for Scientific Research on Analysis and Synthesis of Multidimensional Immune Organ Network (2017)
  • Place of Presentation: 京都大学芝蘭会館（京都府・京都市）
  • Year and Date: 2017-03-13
• [Funded Workshop] 徳島大学国際免疫学シンポジウム (2016)
  • Place of Presentation: 徳島大学（徳島県・徳島市）
  • Year and Date: 2016-03-03
• [Funded Workshop] 次世代シンポジウム Environment Controlling normal and diseased hematopoietic and immune systems (2016)
  • Place of Presentation: 理化学研究所横浜キャンパス（神奈川県・横浜市）
  • Year and Date: 2016-03-02