| Project Area | Unraveling micro-endophenotypes of psychiatric disorders at the molecular, cellular and circuit levels. |
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| Project/Area Number |
24116001
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| Research Category |
Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)
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| Allocation Type | Single-year Grants |
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| Review Section |
Biological Sciences
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| Research Institution | Tokyo University of Agriculture |
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Principal Investigator |
Kida Satoshi 東京農業大学, 応用生物科学部, 教授 (80301547)
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| Co-Investigator(Kenkyū-buntansha) |
廣瀬 謙造 東京大学, 医学(系)研究科(研究院), 教授 (00292730)
加藤 忠史 国立研究開発法人理化学研究所, その他部局等, その他 (30214381)
吉川 武男 国立研究開発法人理化学研究所, その他部局等, その他 (30249958)
岩本 和也 熊本大学, その他の研究科, 教授 (40342753)
林 朗子 (高木朗子 / 高木 朗子 / 林 朗子(高木朗子)) 東京大学, 医学(系)研究科(研究院), 講師 (60415271)
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| Co-Investigator(Renkei-kenkyūsha) |
HASHIMOTO Kenji 千葉大学, 社会精神保健教育研究センター, 教授 (10189483)
TOMITA Hiroaki 東北大学, 災害科学国際研究所, 教授 (90295064)
NAWA Hiroyuki 新潟大学, 脳研究所, 教授 (50183083)
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| Project Period (FY) |
2012-06-28 – 2017-03-31
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| Project Status |
Completed (Fiscal Year 2016)
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| Budget Amount *help |
¥249,860,000 (Direct Cost: ¥192,200,000、Indirect Cost: ¥57,660,000)
Fiscal Year 2016: ¥41,080,000 (Direct Cost: ¥31,600,000、Indirect Cost: ¥9,480,000)
Fiscal Year 2015: ¥36,400,000 (Direct Cost: ¥28,000,000、Indirect Cost: ¥8,400,000)
Fiscal Year 2014: ¥37,440,000 (Direct Cost: ¥28,800,000、Indirect Cost: ¥8,640,000)
Fiscal Year 2013: ¥40,560,000 (Direct Cost: ¥31,200,000、Indirect Cost: ¥9,360,000)
Fiscal Year 2012: ¥94,380,000 (Direct Cost: ¥72,600,000、Indirect Cost: ¥21,780,000)
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| Keywords | 神経科学 / 精神疾患 / 脳・神経 / 精神病態 / マイクロエンドフェノタイプ / PTSD / 統合失調症 / 気分障害 / 双極性障害 / 躁うつ病 / 神経科学科学 / マイクロエンドフェアタイプ / うつ病 |
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| Outline of Final Research Achievements |
To develop basic research on psychiatric disorders, we tried to identify “micro-endophenotypes” that are the visualized phenotypes of psychiatric disorders at the molecular, cellular and circuit levels, as an interface between basic and clinical studies, and understand their molecular basis. To do this, we had more than 7 meetings to present and share our findings and employed support activities for scientist in this innovative area by providing with analyses of next generation sequence and epigenome, imaging using two-photon excitation microscopy and STORM/STED, iPS cells derived from patients of psychiatric disorders and so on. We also encouraged young scientists to join basic research fields of psychiatric disorders. Through these activities, we identified candidates of micro-endophenotypes of psychiatric disorders such as schizophrenia, bipolar disorders, PTSD and depression and furthermore, developed state-of-the-art technologies to identify and analyze micro-endophenotypes.
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