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Promotion of the Transcription Cycle Area

Administrative Group

Project AreaIntegral understanding of the mechanism of transcription cycle through quantitative, high-resolution approaches
Project/Area Number 24118001
Research Category

Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)

Allocation TypeSingle-year Grants
Review Section Biological Sciences
Research InstitutionTokyo Institute of Technology

Principal Investigator

YAMAGUCHI Yuki  東京工業大学, 生命理工学院, 教授 (50345360)

Co-Investigator(Kenkyū-buntansha) 十川 久美子  東京工業大学, 生命理工学院, 准教授 (20291073)
中村 春木  大阪大学, たんぱく質研究所, 教授 (80134485)
松本 直通  横浜市立大学, 医学(系)研究科(研究院), 教授 (80325638)
高橋 陽介  広島大学, 理学(系)研究科(研究院), 教授 (90183855)
緒方 一博  横浜市立大学, 医学(系)研究科(研究院), 教授 (90260330)
伊藤 敬  長崎大学, 医歯(薬)学総合研究科, 教授 (90306275)
Research Collaborator ISHI Shunsuke  理化学研究所, 主任研究員
TANAKA Kiyoji  大阪大学, 教授
HIROSE Susumu  国立遺伝学研究所, 教授
SHIOMI Haruhiko  慶応義塾大学, 教授
SATO Fumitoshi  東京大学, 教授
Project Period (FY) 2012-06-28 – 2017-03-31
Project Status Completed (Fiscal Year 2016)
Budget Amount *help
¥119,340,000 (Direct Cost: ¥91,800,000、Indirect Cost: ¥27,540,000)
Fiscal Year 2016: ¥10,400,000 (Direct Cost: ¥8,000,000、Indirect Cost: ¥2,400,000)
Fiscal Year 2015: ¥8,580,000 (Direct Cost: ¥6,600,000、Indirect Cost: ¥1,980,000)
Fiscal Year 2014: ¥10,530,000 (Direct Cost: ¥8,100,000、Indirect Cost: ¥2,430,000)
Fiscal Year 2013: ¥8,580,000 (Direct Cost: ¥6,600,000、Indirect Cost: ¥1,980,000)
Fiscal Year 2012: ¥81,250,000 (Direct Cost: ¥62,500,000、Indirect Cost: ¥18,750,000)
Keywords転写サイクル / 遺伝子 / 発現制御 / 生体生命情報学 / 分子認識 / 1分子計測
Outline of Final Research Achievements

The goal of the Transcription Cycle Area is to gain an integrative perspective on multiple steps and layers of transcription using “high-resolution approaches,” in which leading edge technology and computational science are combined with conventional methodology. To facilitate research activity of the area toward this goal, the following support programs were conducted as planned: (1) Establishment and management of the Transcription Cycle Core Facility. (2) Promotion of cooperation within the Area and with outside groups. (3) Support of young researchers. (4) Public relations.

Report

(6 results)
  • 2016 Annual Research Report   Final Research Report ( PDF )
  • 2015 Annual Research Report
  • 2014 Annual Research Report
  • 2013 Annual Research Report
  • 2012 Annual Research Report
  • Research Products

    (523 results)

All 2017 2016 2015 2014 2013 2012 2011 Other

All Int'l Joint Research (2 results) Journal Article (193 results) (of which Int'l Joint Research: 63 results,  Peer Reviewed: 192 results,  Open Access: 86 results,  Acknowledgement Compliant: 78 results) Presentation (310 results) (of which Int'l Joint Research: 26 results,  Invited: 67 results) Book (10 results) Remarks (4 results) Patent(Industrial Property Rights) (4 results) (of which Overseas: 2 results)

  • [Int'l Joint Research] システムバイオロジー研究所/UT Southwestern Medical Center at Dallas/カーネギー研究所(米国)

    • Related Report
      2015 Annual Research Report
  • [Int'l Joint Research] オックスフォード大学(英国)

    • Related Report
      2015 Annual Research Report
  • [Journal Article] 転写反応の生化学2017

    • Author(s)
      山口雄輝
    • Journal Title

      生体の科学

      Volume: 68(3)

    • Related Report
      2016 Annual Research Report
  • [Journal Article] Autophosphorylation affects substrate-binding affinity of tobacco Ca2+-dependent protein kinase12017

    • Author(s)
      Ito, T., Ishida, S., Oe, S., Fukazawa, J. and Takahashi, Y.
    • Journal Title

      Plant Physiol.

      Volume: 印刷中

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] DELLA-GAF1 complex is a main component in gibberellin feedback regulation of GA20ox2 in Arabidopsis2017

    • Author(s)
      Fukazawa, J., Mori, M., Watanabe, S., Miyamoto, C., Ito, T. and Takahashi, Y.
    • Journal Title

      Plant Physiol.

      Volume: 印刷中

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Conformational changes in inhibitory PAS domain protein associated with binding of HIF-1α and Bcl-xL in living cells2017

    • Author(s)
      S. Kasai, S. Kajimoto, Y. Ito, T. Saito, K. Yasumoto, M. Tokunaga, K. Sakata-Sogawa, H. Fukumura, K. Sogawa
    • Journal Title

      J. Biochem.

      Volume: 161 Pages: 291-296

    • DOI

      10.1093/jb/mvw068

    • NAID

      40021162091

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] MKRN2 is a novel ubiquitin E3 ligase for the p65 subunit of NF-κB and negatively regulates inflammatory responses2017

    • Author(s)
      Shin C, Ito Y, Ichikawa S, Tokunaga M, Sakata-Sogawa K, Tanaka T
    • Journal Title

      Scientific Reports

      Volume: 7 Issue: 1 Pages: 46097-46097

    • DOI

      10.1038/srep46097

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] A novel GFI1B mutation at the first zinc finger domain causes congenital macrothrombocytopenia2017

    • Author(s)
      Uchiyama Y, Ogawa Y, Kunishima S, Shiina M, Nakashima M, Yanagisawa K, Yokohama A, Imagawa E, Miyatake S, Mizuguchi T, Takata A, Miyake N, Ogata K, Handa H, Matsumoto N
    • Journal Title

      British Journal of Haematology

      Volume: 印刷中 Issue: 6 Pages: 843-847

    • DOI

      10.1111/bjh.14710

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Molecular mechanisms of cooperative binding of transcription factors Runx1-CBFβ-Ets1 on the TCRα gene enhancer2017

    • Author(s)
      Kasahara K, Shiina M, Fukuda I, Ogata K, Nakamura H
    • Journal Title

      PloS One

      Volume: 12 Issue: 2 Pages: e0172654-e0172654

    • DOI

      10.1371/journal.pone.0172654

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Biallelic mutations in the 3' exonuclease TOE1 cause pontocerebellar hypoplasia and uncover a role in snRNA processing2017

    • Author(s)
      Lardelli RM, Schaffer AE, Eggens VR, ... Matsumoto N, Muramatsu K, Saitsu H, Shiina M, Ogata K, Foulds N, Dobyns WB, Chi NC, Traver D, Spaccini L, Bova SM, Gabriel SB, Gunel M, Valente EM, Nassogne MC, Bennett EJ, Yeo GW, Baas F, Lykke-Andersen J, Gleeson JG
    • Journal Title

      Nature Genetics

      Volume: 49 Issue: 3 Pages: 457-464

    • DOI

      10.1038/ng.3762

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] PARS2 and NARS2 mutations in infantile-onset neurodegenerative disorder2017

    • Author(s)
      Mizuguchi T, Nakashima M, Kato M, Yamada K, Okanishi T, Ekhilevitch N, Mandel H, Eran A, Toyono M, Sawaishi Y, Motoi H, Shiina M, Ogata K, Miyatake S, Miyake N, Saitsu H, Matsumoto N
    • Journal Title

      Journal of Human Genetics

      Volume: 62 Issue: 5 Pages: 525-529

    • DOI

      10.1038/jhg.2016.163

    • NAID

      40021210259

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] Biallelic mutations in MYPN, encoding Myopalladin, are associated with childhood-onset, slowly progressive nemaline myopathy2017

    • Author(s)
      Miyatake S, Mitsuhashi S, Hayashi YK, Purevjav E, Nishikawa A, Koshimizu E, Suzuki M, Yatabe K, Tanaka Y, Ogata K, Kuru S, Shiina M, Tsurusaki Y, Nakashima M, Mizuguchi T, Miyake N, Saitsu H, Ogata K, Kawai M, Towbin J, Nonaka I, Nishino I, Matsumoto N
    • Journal Title

      American Journal of Human Genetics

      Volume: 100 Issue: 1 Pages: 169-178

    • DOI

      10.1016/j.ajhg.2016.11.017

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] Distal arthrogryposis with variable clinical expression caused by TNNI2 mutation2017

    • Author(s)
      Culic V, Miyake N, Jankovic S, Petrovic D, Simunovic M, Dapic T, Shiina M, Ogata K, Matsumoto N
    • Journal Title

      Human Genome Variation

      Volume: 3 Issue: 1 Pages: 16035-16035

    • DOI

      10.1038/hgv.2016.35

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] The first report of Japanese patients with asparagine synthetase deficiency2017

    • Author(s)
      Yamamoto T, Endo W, Ohnishi H, Kubota K, Kawamoto N, Inui T, Imamura A, Takanashi JI, Shiina M, Saitsu H, Ogata K, Matsumoto N, Haginoya K, Fukao T
    • Journal Title

      Brain Development

      Volume: 39 Issue: 3 Pages: 236-242

    • DOI

      10.1016/j.braindev.2016.09.010

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Biallelic TBCD mutations cause early-onset neurodegenerative encephalopathy2017

    • Author(s)
      Miyake N, Fukai R, Ohba C, ... Shiina M, Ogata K, Okuno-Yuguchi J, Fueki N, Ogiso Y, Suzumura H, Watabe Y, Imataka G, Leong HY, Fattal-Valevski A, Kramer U, Miyatake S, Kato M, Okamoto N, Sato Y, Mitsuhashi S, Nishino I, Kaneko N, Nishiyama A, Tamura T, Mizuguchi T, Nakashima M, Tanaka F, Saitsu H, Matsumoto N
    • Journal Title

      American Journal of Human Genetics

      Volume: 99 Issue: 4 Pages: 950-961

    • DOI

      10.1016/j.ajhg.2016.08.005

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] Enhancement of canonical sampling by virtual-state transitions2017

    • Author(s)
      Junichi Higo, Kota Kasahara, Bhaskar Dasgupta, Haruki Nakamura
    • Journal Title

      J. Chem. Phys.

      Volume: 146 Issue: 4 Pages: 44104-44104

    • DOI

      10.1063/1.4974087

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Ultra-sensitive droplet digital PCR for detecting a low-prevalence somatic GNAQ mutation in Sturge-Weber syndrome.2016

    • Author(s)
      Uchiyama Y, Nakashima M, Watanabe S, Miyajima M, Taguri M, Miyatake S, Miyake N, Saitsu H, Mishima H, Kinoshita A, Arai H, Yoshiura K, Matsumoto N.
    • Journal Title

      Scientific Reports

      Volume: 6 Issue: 1 Pages: 22985-22985

    • DOI

      10.1038/srep22985

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] FDG-PET study of patients with Leigh syndrome2016

    • Author(s)
      Haginoya K, Kaneta T, Togashi N, Hino-Fukuyo N, Kobayashi T, Uematsu M, Kitamura T, Inui T, Okubo Y, Takezawa Y, Anzai M, Endo W, Miyake N, Saitsu H, Matsumoto N, Kure S.
    • Journal Title

      J Neurol Sci

      Volume: 362 Pages: 309-313

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Pathogenic Variants in PIGG Cause Intellectual Disability with Seizures and Hypotonia2016

    • Author(s)
      Makrythanasis P, Kato M, Zaki MS, Saitsu H, Nakamura K, Santoni FA, Miyatake S, Nakashima M, Issa MY, Guipponi M, Letourneau A, Logan CV, Roberts N, Parry DA, Johnson CA, Matsumoto N, Hamamy H, Sheridan E, Kinoshita T, Antonarakis SE, Murakami Y.
    • Journal Title

      Am J Hum Genet

      Volume: 98 Issue: 4 Pages: 615-626

    • DOI

      10.1016/j.ajhg.2016.02.007

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Mislocalization of syntaxin-1 and impaired neurite growth observed in a human iPSC model for STXBP1-related epileptic encephalopathy.2016

    • Author(s)
      Yamashita S, Chiyonobu T, Yoshida M, Maeda H, Zuiki M, Kidowaki S, Isoda K, Morimoto M, Kato M, Saitsu H, Matsumoto N, Nakahata T, Saito MK, Hosoi H
    • Journal Title

      Epilepsia

      Volume: 57 Issue: 4

    • DOI

      10.1111/epi.13338

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] Detection of low-prevalence somatic TSC2 mutations in sporadic pulmonary lymphangioleiomyomatosis tissues by deep sequencing.2016

    • Author(s)
      Fujita A, Ando K, Kobayashi E, Mitani K, Okudera K, Nakashima M, Miyatake S, Tsurusaki Y, Saitsu H, Seyama K, Miyake N, Matsumoto N.
    • Journal Title

      Hum Genet.

      Volume: 135(1) Issue: 1 Pages: 61-68

    • DOI

      10.1007/s00439-015-1611-0

    • Related Report
      2016 Annual Research Report 2015 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] A novel homozygous mutation in HSF4 causing autosomal recessive congenital cataract.2016

    • Author(s)
      Behnam M, Imagawa E, Chaleshtori AR, Ronasian F, Salehi M, Miyake N, Matsumoto N.
    • Journal Title

      J Hum Genet.

      Volume: 61 Issue: 2 Pages: 177-179

    • DOI

      10.1038/jhg.2015.127

    • NAID

      40020742278

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] Novel COL4A1 mutation in an infant with severe dysmorphic syndrome with schizencephaly, periventricular calcifications, and cataract resembling congenital infection.2016

    • Author(s)
      Smigiel R, Cabala M, Jakubiak A, Kodera H, Sasiadek MJ, Matsumoto N, Sasiadek MM, Saitsu H.
    • Journal Title

      Birth Defects Res A Clin Mol Teratol

      Volume: 106 Issue: 4 Pages: 304-307

    • DOI

      10.1002/bdra.23488

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Homozygous p.V116* mutation in C12orf65 results in Leigh syndrome.2016

    • Author(s)
      Imagawa E, Fattal-Valevski A, Eyal O, Miyatake S, Saada A, Nakashima M, Tsurusaki Y, Saitsu H, Miyake N, Matsumoto N.
    • Journal Title

      J Neurol Neurosurg Psychiatry.

      Volume: 87(2) Pages: 212-216

    • DOI

      10.1136/jnnp-2014-310084

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] De novo missense mutations in NALCN cause developmental and intellectual impairment with hypotonia2016

    • Author(s)
      Fukai R, Saitsu H, Okamoto N, Sakai Y, Fattal-Valevski A, Masaaki S, Kitai Y, Torio M, Kojima-Ishii K, Ihara K, Nakashima M, Miyatake S, Tanaka F, Miyake N, Matsumoto N
    • Journal Title

      J Hum Genet

      Volume: 61 Issue: 5 Pages: 451-455

    • DOI

      10.1038/jhg.2015.163

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] Dyschromatosis symmetrica hereditaria and Aicardi-Goutires syndrome 6 are phenotypic variants caused by ADAR1 mutations.2016

    • Author(s)
      Kono M, Matsumoto F, Suzuki Y, Suganuma M, Saitsu H, Ito Y, Fujiwara S, Matsumoto K, Moriwaki S, Matsumoto N, Tomita Y, Sugiura K, Akiyama M.
    • Journal Title

      J Invest Dermatol.

      Volume: 136 Issue: 4 Pages: 875-8

    • DOI

      10.1016/j.jid.2015.12.034

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Vein of Galen Aneurysmal malformation in monozygotic twin2016

    • Author(s)
      Komiyama M, Miyatake M Watanabe Y, Terada A, Ishiguro T, Ichiba H, Matsumoto M
    • Journal Title

      World Neurosurg

      Volume: 91:672 Pages: 672.e11-672.e15

    • DOI

      10.1016/j.wneu.2016.04.031

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] De novo KCNH1 mutations in four patients with syndromic developmental delay, hypotonia and seizures.2016

    • Author(s)
      Fukai R, Saitsu H, Tsurusaki Y, Sakai Y, Haginoya K, Takahashi K, Hubshman MW, Okamoto N, Nakashima M, Tanaka F, Miyake N, Matsumoto N
    • Journal Title

      J Hum Genet

      Volume: 61 Issue: 5 Pages: 381-387

    • DOI

      10.1038/jhg.2016.1

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] Two cases of early-onset myoclonic seizures with continuous parietal delta activity caused by EEF1A2 mutations2016

    • Author(s)
      Inui T, Kobayashi S, Ashikari Y, Sato R, Endo W, Uematsu M, Oba H, Saitsu H, Matsumoto N, Kure S, Haginoya K.
    • Journal Title

      Brain Dev.

      Volume: 38 Issue: 5 Pages: 520

    • DOI

      10.1016/j.braindev.2015.11.003

    • URL

      https://pure.teikyo.jp/en/publications/4f3c87fd-96ab-434e-b029-da15e1ab9c22

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] Impaired neuronal KCC2 function by biallelic SLC12A5 mutations in migrating focal seizures and severe developmental delay.2016

    • Author(s)
      Saitsu H, Watanabe M, Akita T, Ohba C, Sugai K, Ong WP, Shiraishi H, Yuasa S, Matsumoto H, Beng KT, Saitoh S, Miyatake S, Nakashima M, Miyake N, Kato M, Fukuda A. and Matsumoto N.
    • Journal Title

      Scientific Reports

      Volume: 6 Issue: 1 Pages: 30072-30072

    • DOI

      10.1038/srep30072

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] De novo truncating mutation of TRIM8 causes early-onset epileptic encephalopathy2016

    • Author(s)
      Sakai Y#, Fukai R# (# denotes equal contribution), Matsushita Y, Miyake N, Saitsu H, Akamine S, Torio M, Sasazaki M, Ishizaki Y, Sanefuji M, Torisu H, Shaw CA, Matsumoto N, Hara T
    • Journal Title

      Ann Hum Genet

      Volume: 80 Issue: 4 Pages: 235-240

    • DOI

      10.1111/ahg.12157

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] SMARCE1, a rare cause of Coffin-Siris Syndrome: Clinical description of three additional cases2016

    • Author(s)
      Zarate YA, Bhoj E, Kaylor J, Li D, Tsurusaki Y, Miyake N, Matsumoto N, Phadke S, Escobar L, Irani A, Hakonarson H, Schrier Vergano SA
    • Journal Title

      Am J Med Genet A

      Volume: 170 Issue: 8 Pages: 1967-1973

    • DOI

      10.1002/ajmg.a.37722

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] SAMD9 mutations cause a novel multisystem disorder, MIRAGE syndrome, and are associated with loss of chromosome 72016

    • Author(s)
      Narumi S*, et al., Matsumoto N, et al.
    • Journal Title

      Nat Genet

      Volume: 48 Issue: 7 Pages: 792-797

    • DOI

      10.1038/ng.3569

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] De novo p.Arg756Cys mutation of ATP1A3 causes an atypical form of alternating hemiplegia of childhood with prolonged paralysis and choreoathetosis2016

    • Author(s)
      Kanemasa H, Fukai R, Sakai Y, Torio M, Miyake N, Lee S, Ono H, Akamine S, Nishiyama K, Sanefuji M, Ishizaki Y, Torisu H, Saitsu H, Matsumoto N, Hara T
    • Journal Title

      BMC Neurol

      Volume: 16 Issue: 1 Pages: 174-174

    • DOI

      10.1186/s12883-016-0680-6

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] The first genetically confirmed Japanese patient with mucolipidosis type IV2016

    • Author(s)
      Saijo H, Hayashi M, Ezoe T, Ohba C, Saitsu H, Kurata K, Matsumoto N
    • Journal Title

      Clin Case Rep

      Volume: 4 Issue: 5 Pages: 509-512

    • DOI

      10.1002/ccr3.540

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] The first Japanese case of leukodystrophy with ovarian failure arising from novel compound heterozygous AARS2 mutations2016

    • Author(s)
      Hamatani M, Jingami N, Tsurusaki Y, Shimada S, Shimojima K, Asada-Utsugi M, Yoshinaga K, Uemura N, Yamashita H, Uemura K, Takahashi R, Matsumoto N, Yamamoto T
    • Journal Title

      J Hum Genet

      Volume: 61 Issue: 10 Pages: 899-902

    • DOI

      10.1038/jhg.2016.64

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Molecular genetic analysis of 30 families with Joubert syndrome2016

    • Author(s)
      Suzuki T, et al., Matsumoto N
    • Journal Title

      Clin Genet

      Volume: 90 Issue: 6 Pages: 526-535

    • DOI

      10.1111/cge.12836

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] Distinct but milder phenotypes with choreiform movements in siblings with compound heterozygous mutations in the transcription preinitiation mediator complex subunit 17 (MED17)2016

    • Author(s)
      Hirabayashi S, Saitsu H, Matsumoto N
    • Journal Title

      Brain Dev

      Volume: 38 Issue: 1 Pages: 118-123

    • DOI

      10.1016/j.braindev.2015.05.004

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Diagnosis of pancreatic lesions collected by endoscopic ultrasound-guided fine-needle aspiration using next-generation sequencing2016

    • Author(s)
      Kameta E, Sugimori K, Kaneko T, Ishii T, Miwa H, Sato T, Ishii Y, Sue S, Sasaki T, Yamashita Y, Shibata W, Matsumoto N, Maeda S
    • Journal Title

      Oncol Lett

      Volume: 12 Issue: 5 Pages: 3875-3881

    • DOI

      10.3892/ol.2016.5168

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Autosomal-recessive mutations in AP3B2, adaptor-related protein complex 3 beta 2 subunit, cause an early-onset epileptic encephalopathy with optic atrophy2016

    • Author(s)
      Assoum M, Philippe C, et al., Matsumoto N, et al.
    • Journal Title

      Am J Hum Genet

      Volume: 99 Issue: 6 Pages: 1368-1376

    • DOI

      10.1016/j.ajhg.2016.10.009

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] The molecular and phenotypic spectrum of IQSEC2-related epilepsy2016

    • Author(s)
      Zerem A, et al., Matsumoto N, et al.
    • Journal Title

      Epilepsia

      Volume: 57 Issue: 11 Pages: 1858-1869

    • DOI

      10.1111/epi.13560

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Association between invisible basal ganglia and ZNF335 mutations: a case report2016

    • Author(s)
      Sato R, Takanashi J, Tsuyusaki Y, Kato M, Saitsu H, Matsumoto N, Takahashi T
    • Journal Title

      Pediatrics

      Volume: 138 Issue: 3

    • DOI

      10.1542/peds.2016-0897

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Megalencephaly, polymicrogyria and ribbon-like band heterotopia: A new cortical malformation2016

    • Author(s)
      Kobayashi Y, Magara S, Okazaki K, Komatsubara T, Saitsu H, Matsumoto N, Kato M, Tohyama J
    • Journal Title

      Brain Dev

      Volume: 38 Issue: 10 Pages: 950-953

    • DOI

      10.1016/j.braindev.2016.06.004

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] A female case of aromatic l-amino acid decarboxylase deficiency responsive to MAO-B inhibition2016

    • Author(s)
      Kojima K, Anzai R, Ohba C, Goto T, Miyauchi A, Thony B, Saitsu H, Matsumoto N, Osaka H, Yamagata T
    • Journal Title

      Brain Dev

      Volume: 38 Issue: 10 Pages: 959-963

    • DOI

      10.1016/j.braindev.2016.06.002

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Clinical features of SMARCA2 duplication overlap with Coffin-Siris syndrome2016

    • Author(s)
      Miyake N, Abdel-Salam G, Yamagata T, Eid MM, Osaka H, Okamoto N, Mohamed AM, Ikeda T, Afifi HH, Piard J, van Maldergem L, Mizuguchi T, Miyatake S, Tsurusaki Y, Matsumoto N
    • Journal Title

      Am J Med Genet A

      Volume: 170 Issue: 10 Pages: 2662-2670

    • DOI

      10.1002/ajmg.a.37778

    • Related Report
      2016 Annual Research Report
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  • [Journal Article] De novo MEIS2 mutation causes syndromic developmental delay with persistent gastro-esophageal reflux2016

    • Author(s)
      Fujita A, Isidor B, Piloquet H, Corre P, Okamoto N, Nakashima M, Tsurusaki Y, Saitsu H, Miyake N, Matsumoto N
    • Journal Title

      J Hum Genet

      Volume: 61 Issue: 9 Pages: 835-838

    • DOI

      10.1038/jhg.2016.54

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      2016 Annual Research Report
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  • [Journal Article] First Japanese variant of late infantile neuronal ceroid lipofuscinosis caused by novel CLN6 mutations2016

    • Author(s)
      Sato R, Inui T, Endo W, Okubo Y, Takezawa Y, Anzai M, Morita H, Saitsu H, Matsumoto N, Haginoya K
    • Journal Title

      Brain Dev

      Volume: 38 Issue: 9 Pages: 852-826

    • DOI

      10.1016/j.braindev.2016.04.007

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Identification of biallelic LRRK1 mutations in osteosclerotic metaphyseal dysplasia and evidence for locus heterogeneity2016

    • Author(s)
      Iida A, Xing W, Docx MK, Nakashima T, Wang Z, Kimizuka M, Van Hul W, Rating D, Spranger J, Ohashi H, Miyake N, Matsumoto N, Mohan S, Nishimura G, Mortier G, Ikegawa S
    • Journal Title

      J Med Genet

      Volume: 53 Issue: 8 Pages: 568-574

    • DOI

      10.1136/jmedgenet-2016-103756

    • Related Report
      2016 Annual Research Report
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  • [Journal Article] High prevalence of genetic alterations in early-onset epileptic encephalopathies associated with infantile movement disorders.2016

    • Author(s)
      Kobayashi Y, Tohyama J, Kato M, Akasaka N, Magara S, Kawashima H, Ohashi T, Shiraishi H, Nakashima M, Saitsu H, Matsumoto N.
    • Journal Title

      Brain Dev.

      Volume: 38 Issue: 7 Pages: 285-92

    • DOI

      10.1038/jhg.2016.27

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      2016 Annual Research Report
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  • [Journal Article] Milder progressive cerebellar atrophy caused by biallelic SEPSECS mutations2016

    • Author(s)
      Iwama K, Sasaki M, Hirabayashi S, Ohba C, Iwabuchi E, Miyatake S, Nakashima M, Miyake N, Ito S, Saitsu H, Matsumoto N
    • Journal Title

      J Hum Genet

      Volume: 61 Issue: 6 Pages: 527-531

    • DOI

      10.1038/jhg.2016.9

    • Related Report
      2016 Annual Research Report
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  • [Journal Article] Dermatan 4-O-sulfotransferase 1-deficient Ehlers-Danlos syndrome complicated by a large subcutaneous hematoma on the back.2016

    • Author(s)
      Mochida K, Amano M, Miyake N, Matsumoto N, Hatamochi A, Kosho T.
    • Journal Title

      J Dermatol.

      Volume: Epub ahead of print Issue: 7 Pages: 1-2

    • DOI

      10.1111/1346-8138.13273

    • Related Report
      2016 Annual Research Report
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  • [Journal Article] mDCC_tools: Characterizing Multi-modal Atomic Motions in Molecular Dynamics Trajectories2016

    • Author(s)
      Kota Kasahara, Neetha Mohan, Ikuo Fukuda, Haruki Nakamura
    • Journal Title

      Bioinformatics

      Volume: 32 Issue: 16 Pages: 2531-2533

    • DOI

      10.1093/bioinformatics/btw129

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Elastic properties of dynein motor domain obtained from all-atom molecular dynamics simulations2016

    • Author(s)
      Narutoshi Kamiya, Tadaaki Mashimo, Yu Takano, Takahide Kon, Genji Kurisu, Haruki Nakamura
    • Journal Title

      Protein Engineering, Design and Selection

      Volume: 29 Issue: 8 Pages: 317-325

    • DOI

      10.1093/protein/gzw022

    • Related Report
      2016 Annual Research Report
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  • [Journal Article] Rapid and efficient analysis of gene function using CRISPR-Cas9 in Xenopus tropicalis founders2016

    • Author(s)
      Shigeta, Mitsuki; Sakane, Yuto; Iida, Midori; Suzuki, Miyuki; Kashiwagi, Keiko; Kashiwagi, Akihiko; Fujii, Satoshi; Yamamoto, Takashi; Suzuki, Ken-ichi
    • Journal Title

      Genes to Cells

      Volume: in press Issue: 7 Pages: 755-771

    • DOI

      10.1111/gtc.12379

    • Related Report
      2016 Annual Research Report
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  • [Journal Article] Revisiting Antibody Modeling Assessment for CDR-H3 loop2016

    • Author(s)
      Hiroshi Nishigami, Narutoshi Kamiya, Haruki Nakamura
    • Journal Title

      Protein Engineering, Design and Selection

      Volume: 29 Issue: 11 Pages: 477-484

    • DOI

      10.1093/protein/gzw028

    • Related Report
      2016 Annual Research Report
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  • [Journal Article] Identification of aryl hydrocarbon receptor signaling pathways altered in TCDD- treated red seabream embryos by transcriptome analysis2016

    • Author(s)
      Midori Iida, Satoshi Fujii, Masaya Uchida, , Hiroshi Nakamura, Yoshihiro Kagami, Tetsuro Agusa, Masashi Hirano, Su-Min Bak, Eun-Young Kim, Hisato Iwata
    • Journal Title

      Aquatic Toxicology

      Volume: 177 Pages: 156-170

    • DOI

      10.1016/j.aquatox.2016.05.014

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] myPresto/omegagene: a GPU-accelerated molecular dynamics simulator tailored for enhanced conformational sampling methods with a non-Ewald electrostatic scheme2016

    • Author(s)
      Kota Kasahara, Benson Ma, Kota Goto, Bhaskar Dasgupta, Junichi Higo, Ikuo Fukuda, Tadaaki Mashimo, Yutaka Akiyama, Haruki Nakamura
    • Journal Title

      Biophysics and Physicobiology

      Volume: 13 Issue: 0 Pages: 209-216

    • DOI

      10.2142/biophysico.13.0_209

    • NAID

      130007041560

    • ISSN
      2189-4779
    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] Variation of Free-Energy Landscape of the p53 C-terminal Domain Induced by Acetylation: Enhanced Conformational Sampling2016

    • Author(s)
      Shinji Iida, Tadaaki Mashimo, Takashi Kurosawa, Hironobu Hojo, Hiroya Muta, Yuji Goto, Yoshifumi Fukunishi, Haruki Nakamura, Junichi Higo
    • Journal Title

      J. Comput. Chem.

      Volume: 37 Issue: 31 Pages: 2687-2700

    • DOI

      10.1002/jcc.24494

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      2016 Annual Research Report
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  • [Journal Article] Haem-dependent dimerization of PGRMC1/Sigma-2 receptor facilitates cancer proliferation and chemoresistance.2016

    • Author(s)
      Kabe Y, Nakane T, Koike I, Yamamoto T, Sugiura Y, Harada E, Sugase K, Shimamura T, Ohmura M, Muraoka K, Yamamoto A, Uchida T, Iwata S, Yamaguchi Y, Krayukhina E, Noda M, Handa H, Ishimori K, Uchiyama S, Kobayashi T, Suematsu M.
    • Journal Title

      Nature Communications

      Volume: 7 Issue: 1 Pages: 11030-11030

    • DOI

      10.1038/ncomms11030

    • NAID

      130007529314

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      2015 Annual Research Report
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  • [Journal Article] SMARCAD1 is an ATP-dependent stimulator of nucleosomal H2A acetylation via CBP, resulting in transcriptional regulation.2016

    • Author(s)
      Doiguchi M
    • Journal Title

      Sci. Rep.

      Volume: 6 Issue: 1 Pages: 20179-20179

    • DOI

      10.1038/srep20179

    • Related Report
      2015 Annual Research Report
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  • [Journal Article] Phenotypic spectrum of GNAO1 variants: Epileptic encephalopathy to involuntary movements with severe developmental delay2016

    • Author(s)
      Saitsu H, Fukai R, Ben-Zeev B, Sakai Y, Mimaki M, Okamoto N, Suzuki Y, Monden Y, Saito H, Tziperman B, Torio M, Akamine S, Takahashi N, Osaka H, Yamagata T, Nakamura K, Tsurusaki Y, Nakashima M, Miyake N, Shiina M, Ogata K, Matsumoto N
    • Journal Title

      Eur J Hum Genet

      Volume: 24 Issue: 1 Pages: 129

    • DOI

      10.1038/ejhg.2015.92

    • URL

      https://pure.teikyo.jp/en/publications/06a45aed-f2e5-424a-b8d1-3e9a6923fdc5

    • Related Report
      2015 Annual Research Report
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  • [Journal Article] Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition)2016

    • Author(s)
      Klionsky DJ., Abdelmohsen K., Abe A., Abedin MJ.,Inomata M., et al.
    • Journal Title

      Autophagy

      Volume: 12(1) Issue: 1 Pages: 1-222

    • DOI

      10.1080/15548627.2015.1100356

    • Related Report
      2015 Annual Research Report
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  • [Journal Article] FDG-PET study of patients with Leigh syndrome2016

    • Author(s)
      Haginoya K, Kaneta T, Togashi N, Hino-Fukuyo N, Kobayashi T, Uematsu M, Kitamura T, Inui T, Okubo Y, Takezawa Y, Anzai M, Endo W, Miyake M, Saitsu H, Matsumoto N, Kure S
    • Journal Title

      Journal of the Neurological Sciences

      Volume: 362 Pages: 309-313

    • DOI

      10.1016/j.jns.2016.02.008

    • Related Report
      2015 Annual Research Report
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  • [Journal Article] Omokage search: shape similarity search service for biomolecular structures in both the PDB and EMDB.2016

    • Author(s)
      Hirofumi Suzuki, Takeshi Kawabata, Haruki Nakamura
    • Journal Title

      Bioinformatics

      Volume: 32 Issue: 4 Pages: 619-620

    • DOI

      10.1093/bioinformatics/btv614

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Development of Massive Multilevel Molecular Dynamics Simulation Program, Platypus (PLATform for dYnamic Protein Unified Simulation), for the Elucidation of Protein2016

    • Author(s)
      Takano Y, Nakata K, Yonezawa Y, Nakamura H
    • Journal Title

      Journal of Computational Chemistry

      Volume: 37 Issue: 12 Pages: 1125-1132

    • DOI

      10.1002/jcc.24318

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      2015 Annual Research Report
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  • [Journal Article] A critical appraisal of the zero-multipole method: Structural, thermodynamic, dielectrid, and dynamical properties of a water system2016

    • Author(s)
      Wang H, Nakamura H, Fukuda I
    • Journal Title

      Journal of Chemical Physics

      Volume: 144 Issue: 11 Pages: 114503-114503

    • DOI

      10.1063/1.4943956

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] Density functional study of molecular interactions in secondary structures of proteins2016

    • Author(s)
      Takano Y, Kusaka A, Nakamura H
    • Journal Title

      Biophysics and Physicobiology

      Volume: 13 Issue: 0 Pages: 27-35

    • DOI

      10.2142/biophysico.13.0_27

    • NAID

      130005126232

    • ISSN
      2189-4779
    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] De novo GABRA1 mutations in Ohtahara and West syndromes2015

    • Author(s)
      ○Hirofumi Kodera, et al, Hirotomo Saitsu and Naomichi Matsumoto
    • Journal Title

      Epilepsia

      Volume: 57 Issue: 4 Pages: 566-573

    • DOI

      10.1111/epi.13344

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] Panventriculomegaly with a wide foramen of Magendie and large cisterna magna.2015

    • Author(s)
      Hiroshi Kageyama, Masakazu Miyajima, Ikuko Ogino, Madoka Nakajima, Kazuaki Shimoji, Ryoko Fukai, Noriko Miyake, Kenichi Nishiyama, Naomichi Matsumoto, Hajime Arai
    • Journal Title

      Journal of Neurosurgery

      Volume: E-pub Issue: 6 Pages: 1-9

    • DOI

      10.3171/2015.6.jns15162

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] Characterization of the Human Transcription Elongation Factor Rtf1: Evidence for Non-overlapping Functions of Rtf1 and the Paf1 Complex.2015

    • Author(s)
      Cao, Q. F., C., Yamamoto, J., Isobe, T., Tateno, S., Murase, Y., Chen, Y., Handa, H. and Yamaguchi, Y.
    • Journal Title

      Mol Cell. Biol.

      Volume: 35 Issue: 20 Pages: 3459-3470

    • DOI

      10.1128/mcb.00601-15

    • Related Report
      2015 Annual Research Report
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  • [Journal Article] CTCF regulates NELF, DSIF and P-TEFb recruitment during transcription.2015

    • Author(s)
      Laitem, C., Zaborowska, J., Tellier, M., Yamaguchi, Y., Cao. Q.-F., Egloff, S., Handa, H., and Murphy, S.
    • Journal Title

      Transcription

      Volume: 6 Pages: 79-90

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      2015 Annual Research Report
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  • [Journal Article] Enhancer of Acetyltransferase Chameau(EAChm) Is a Novel Transcriptional Co-Activator2015

    • Author(s)
      Takeya Nakagawa, Tsuyoshi Ikehara, Masamichi Doiguchi, Yuko Imamura, Miki Higashi, Mitsuhiro Yoneda, Takashi Ito
    • Journal Title

      PLoS ONE

      Volume: 10(11) Issue: 11 Pages: e0142305-e0142305

    • DOI

      10.1371/journal.pone.0142305

    • NAID

      120006987224

    • Related Report
      2015 Annual Research Report
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  • [Journal Article] Dzip3 regulates developmental genes in mouse embryonic stem cells by reorganizing 3D chromatin conformation.2015

    • Author(s)
      Inoue D, Aihara H, Sato T, Mizusaki H, Doiguchi M, Higashi M, Imamura Y, Yoneda M, Miyanishi T, Fujii S, Okuda A, Nakagawa T, Ito T
    • Journal Title

      Scientific Reports

      Volume: 5 Issue: 1 Pages: 16567-16567

    • DOI

      10.1038/srep16567

    • NAID

      120006986837

    • Related Report
      2015 Annual Research Report
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  • [Journal Article] Binding of GID1 to DELLAs Promotes Dissociation of GAF1 from DELLA in GA Dependent Manner2015

    • Author(s)
      Fukazawa, J., Ito, T., Yoshida, M., Kamiya, Y., Yamaguchi, S., and Takahashi, Y.
    • Journal Title

      Plant Signaling and Behavior

      Volume: 10 Issue: 10 Pages: e1052923-e1052923

    • DOI

      10.1080/15592324.2015.1052923

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      2015 Annual Research Report
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  • [Journal Article] Short-lasting unilateral neuralgiform headache attacks with ispilateral facial flushing is a new variant of paroxysmal extreme pain disorder2015

    • Author(s)
      Imai N, Miyake N, Saito Y, Kobayashi E, Ikawa M, Manaka S, Shiina M, Ogata K, Matsumoto N
    • Journal Title

      J Headache Pain

      Volume: 16(1) Issue: 1 Pages: 519-519

    • DOI

      10.1186/s10194-015-0519-3

    • Related Report
      2015 Annual Research Report
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  • [Journal Article] A novel allosteric mechanism on protein-DNA interactions underlying the phosphorylation-dependent regulation of Ets1 target gene expressions2015

    • Author(s)
      Shiina M, Hamada K, Inoue-Bungo T, Shimamura M, Uchiyama A, Baba S, Sato K, Yamamoto M, Ogata K
    • Journal Title

      J Mol Biol

      Volume: 427(8) Issue: 8 Pages: 1655-1669

    • DOI

      10.1016/j.jmb.2014.07.020

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      2015 Annual Research Report 2014 Annual Research Report
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  • [Journal Article] Novel compound heterozygous LIAS mutations cause glycine encephalopathy2015

    • Author(s)
      Tsurusaki Y, Tanaka R, Shimada S, Shimojima K, Shiina M, Nakashima M, Saitsu H, Miyake N, Ogata K, Yamamoto T, Matsumoto N
    • Journal Title

      J Hum Genet

      Volume: 60(10) Issue: 10 Pages: 631-635

    • DOI

      10.1038/jhg.2015.72

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] De novo SHANK3 mutation causes a female patient with Rett syndrome like phenotype.2015

    • Author(s)
      Hara M, Ohba C, Yamashita Y, Saitsu H, Matsumoto N, Matsuishi T.
    • Journal Title

      J Med Genet Part A

      Volume: 167(7) Issue: 7 Pages: 1593-1596

    • DOI

      10.1002/ajmg.a.36775

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      2015 Annual Research Report
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  • [Journal Article] Japanese familial case of myoclonus-dystonia syndrome with a splicing mutation in SGCE.2015

    • Author(s)
      Wada T, Takano K, Tsurusaki Y, Miyake N, Nakashima M, Saitsu H, Matsumoto N, Osaka H.
    • Journal Title

      Pediatr Int.

      Volume: 57 Issue: 2 Pages: 324-326

    • DOI

      10.1111/ped.12613

    • NAID

      120005666180

    • Related Report
      2015 Annual Research Report
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  • [Journal Article] A family of distal arthrogryposis type 5 due to a novel PIEZO2 mutation2015

    • Author(s)
      Okubo M, Fujita A, Saito Y, Komaki H, Ishiyama A, Kojima E, Koichihara R, Saito T, Nakagawa E, Sugai K, Yamazaki H, Kusaka K, Tanaka H, Matsumoto N, Sasaki M
    • Journal Title

      Am J Med Genet Part A

      Volume: 167(5) Issue: 5 Pages: 1100-1106

    • DOI

      10.1002/ajmg.a.36881

    • Related Report
      2015 Annual Research Report
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  • [Journal Article] Mutations in the glutaminyl-tRNA synthetase gene cause early-onset epileptic encephalopathy.2015

    • Author(s)
      Kodera H, Osaka H, Iai M, Aida N, Yamashita A, Tsurusaki Y, Nakashima M, Miyake N, Saitsu H, Matsumoto N.
    • Journal Title

      J Hum Genet.

      Volume: 60(2) Issue: 2 Pages: 97-101

    • DOI

      10.1038/jhg.2014.103

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Detecting copy number variations in whole exome sequencing data using exome hidden markov model - an expectation of “exome-first” approach.2015

    • Author(s)
      Miyatake S, Koshimizu E, Fujita A, Fukai R, Imagawa E, Ohba C, Kuki I, Makita Y, Ogata T, Nakashima M, Tsurusaki Y, Miyake N, Saitsu H, Matsumoto N
    • Journal Title

      J Hum Genet

      Volume: 1 Issue: 4 Pages: 124-124

    • DOI

      10.1038/jhg.2014.124

    • Related Report
      2015 Annual Research Report
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  • [Journal Article] SPTAN1 encephalopathy: distinct phenotypes and genotypes2015

    • Author(s)
      Tohyama J, Nakashima M, Nabatame S, Gaik-Siew C, Miyata R, Rener-Primec Z, Kato M, Matsumoto N, Saitsu H
    • Journal Title

      Journal of Human Genetics

      Volume: 60(4) Issue: 4 Pages: 167-173

    • DOI

      10.1038/jhg.2015.5

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      2015 Annual Research Report
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  • [Journal Article] GRIN1 mutations cause encephalopathy with infantile-onset epilepsy, and hyperkinetic and stereotyped movement disorders2015

    • Author(s)
      Ohba C, Shiina M, Tohyama J, Haginoya K, Lerman-Sagie T, Okamoto N, Blumkin L, Lev D, Mukaida S, Nozaki F, Uematsu M, Onuma A, Kodera H, Nakashima M, Tsurusaki Y, Miyake N, Tanaka F, Kato M, Ogata K, Saitsu H, Matsumoto N
    • Journal Title

      Epilepsia

      Volume: 印刷中 Issue: 6 Pages: 841-848

    • DOI

      10.1111/epi.12987

    • Related Report
      2015 Annual Research Report 2014 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Sporadic infantile-onset spinocerebellar ataxia caused by missense mutations of the inositol 1,4,5-triphosphate receptor type 1 gene.2015

    • Author(s)
      Sasaki M, Ohba C, Iai M, Hirabayashi S, Osaka H, Hiraide T, Saitsu H, Matsumoto N
    • Journal Title

      J Neurol

      Volume: 262(5) Issue: 5 Pages: 1278-1284

    • DOI

      10.1007/s00415-015-7705-8

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      2015 Annual Research Report
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  • [Journal Article] A Japanese case of cerebellar ataxia, spastic paraparesis and deep sensory impairment associated with a novel homozygous TTC19 mutation2015

    • Author(s)
      Kunii M, Doi H, Higashiyama Y, Kugimoto C, Ueda N, Hirata J, Tomita-Katsumoto A, Kashikura-Kojima M, Kubota S, Taniguchi M, Murayama K, Nakashima M, Tsurusaki Y, Miyake N, Saitsu H, Matsumoto N, Tanaka F.
    • Journal Title

      J Hum Genet

      Volume: 60 Issue: 4 Pages: 187-191

    • DOI

      10.1038/jhg.2015.7

    • NAID

      40020433141

    • Related Report
      2015 Annual Research Report
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  • [Journal Article] A case of autism spectrum disorder arising from a de novo missense mutation in POGZ.2015

    • Author(s)
      Fukai R, Hiraki Y, Yofune H, Tsurusaki Y, Nakashima M, Saitsu H, Tanaka F, Miyake N, Matsumoto N.
    • Journal Title

      J Hum Genet.

      Volume: 60(5) Issue: 5 Pages: 277-279

    • DOI

      10.1038/jhg.2015.13

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      2015 Annual Research Report
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  • [Journal Article] An Aberrant Splice Acceptor Site Due to a Novel Intronic Nucleotide Substitution in MSX1 Gene Is the Cause of Congenital Tooth Agenesis in a Japanese Family2015

    • Author(s)
      Tatematsu T, Kimura M, Nakashima M, Machida J, Yamaguchi S, Shibata A, Goto H, Nakayama A, Higashi Y, Miyachi H, Shimozato K, Matsumoto N, Tokita Y
    • Journal Title

      Plos One

      Volume: 10(6) Issue: 6 Pages: e0128227-e0128227

    • DOI

      10.1371/journal.pone.0128227

    • Related Report
      2015 Annual Research Report
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  • [Journal Article] A novel mutation in ELOVL4 leading to spinocerebellar ataxia (SCA) with the hot cross bun sign but lacking erythrokeratodermia: a broadened spectrum of SCA34.2015

    • Author(s)
      Ozaki K, Doi H, Mitsui J, Sato N, Iikuni Y, Majima T, Yamane K, Irioka T, Ishiura H, Doi K, Morishita S, Higashi M, Sekiguchi T, Koyama K, Ueda N, Miura Y, Miyatake S, Matsumoto N, Yokota T, Tanaka F, Tsuji S, Mizusawa H, Ishikawa K.
    • Journal Title

      JAMA Neurology

      Volume: 72 Issue: 7 Pages: 797-805

    • DOI

      10.1001/jamaneurol.2015.0610

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] Novel rare variations of the oxytocin receptor (OXTR) gene in autism spectrum disorder individuals.2015

    • Author(s)
      Liu X, Kawashima M, Miyagawa T, Otowa T, Latt KZ, Thiri M, Nishida H, Sugiyama T, Tsurusaki Y, Matsumoto N, Mabuchi A, Tokunaga K, Sasaki T.
    • Journal Title

      Human Genome Variation

      Volume: 2 Issue: 1 Pages: 15024-15024

    • DOI

      10.1038/hgv.2015.24

    • Related Report
      2015 Annual Research Report
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  • [Journal Article] Predominant cerebellar phenotype in spastic paraplegia 7 (SPG7).2015

    • Author(s)
      Yahikozawa H, Yoshida K, Shunichi S, Hanyu N, Doi H, Miyatake S, Matsumoto N.
    • Journal Title

      Human Genome Variation

      Volume: 2 Issue: 1 Pages: 15015-15015

    • DOI

      10.1038/hgv.2015.12

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Somatic Mutations in the MTOR gene cause focal cortical dysplasia type IIb2015

    • Author(s)
      Nakashima M, Saitsu H, Takei N, Tohyama J, Kato M, Kitaura H, Shiina M, Shirozu H, Masuda H, Watanabe K, Ohba C, Tsurusaki Y, Miyake N, Zheng Y, Sato T, Takebayashi H, Ogata K, Kameyama S, Kakita A, Matsumoto N
    • Journal Title

      Ann. Neurol.

      Volume: 78 Issue: 3 Pages: 375-386

    • DOI

      10.1002/ana.24444

    • Related Report
      2015 Annual Research Report
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  • [Journal Article] Two novel homozygous RAB3GAP1 mutations cause Warburg micro syndrome.2015

    • Author(s)
      Imagawa E, Fukai R, Behnam M, Goyal M, Nouri N, Nakashima M, Tsurusaki Y, Saitsu H, Salehi M, Kapoor S, Tanaka F, Miyake N, Matsumoto N.
    • Journal Title

      Hum Genome Var.

      Volume: 2 Issue: 1 Pages: 15034-15034

    • DOI

      10.1038/hgv.2015.34

    • Related Report
      2015 Annual Research Report
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  • [Journal Article] Electroclinical features of epileptic encephalopathy caused by SCN8A mutation2015

    • Author(s)
      Takahashi S, Yamamoto S, Okayama A, Araki A, Saitsu H, Matsumoto N, Azuma H
    • Journal Title

      Pediatrics International

      Volume: 57(4) Issue: 4 Pages: 758-762

    • DOI

      10.1111/ped.12622

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] DNA methylation and gene expression dynamics during spermatogonial stem cell differentiation in the early postnatal mouse testis.2015

    • Author(s)
      Kubo N, Toh H, Shirane K, Shirakawa T, Kobayashi H, Sato T, Sone H, Sato Y, Tomizawa S, Tsurusaki Y, Shibata H, Saitsu H, Suzuki Y, Matsumoto N, Suyama M, Kono T, Ohbo K, Sasaki H.
    • Journal Title

      BMC Genomics.

      Volume: 16 Issue: 1 Pages: 624-624

    • DOI

      10.1186/s12864-015-1833-5

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] De Novo 17q24.2-q24.3 microdeletion presenting with generalized hypertrichosis terminalis, gingival fibromatous hyperplasia, and distinctive facial features2015

    • Author(s)
      Afifi H, Fukai R, Miyake N, Gamal E, Din A, Eid M, Eid O, Thomas M, El-Badry T, Tosson A, Abdel-Salam G, Matsumoto N
    • Journal Title

      Am J Med Genet Part A

      Volume: 167(10) Issue: 10 Pages: 2418-2424

    • DOI

      10.1002/ajmg.a.37185

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] Biallelic mutations in nuclear pore complex subunit NUP107 cause early-childhood-onset steroid-resistant nephrotic syndrome2015

    • Author(s)
      Miyake N, Tsukaguchi H, Koshimizu E, Shono A, Matsunaga S, Shiina M, Mimura Y, Imamura S, Hirose T, Okudela K, Nozu K, Akioka Y, Hattori M, Yoshikawa N, Kitamura A, Cheong HI, Kagami S, Yamashita M, Fujita A, Miyatake S, Tsurusaki Y, Nakashima M, Saitsu H, Ohashi K, Imamoto N, Ryo A, Ogata K, Iijima K, Matsumoto N
    • Journal Title

      Am J Hum Genet

      Volume: 97(4) Issue: 4 Pages: 555-566

    • DOI

      10.1016/j.ajhg.2015.08.013

    • Related Report
      2015 Annual Research Report
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  • [Journal Article] Identification of HOXD4 Mutations in Spinal Extradural Arachnoid Cyst2015

    • Author(s)
      Ogura Y, Miyake N, Kou I, Iida A, Nakajima M, Takeda K, Fujibayashi S, Shiina M, Okada E, Toyama Y, Iwanami A, Ishii K, Ogata K, Asahara H, Matsumoto N, Nakamura M, Matsumoto M, Ikegawa S
    • Journal Title

      PLoS One

      Volume: 10(11) Issue: 11 Pages: e0142126-e0142126

    • DOI

      10.1371/journal.pone.0142126

    • NAID

      120005763410

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] De novo KCNB1 mutations in infantile epilepsy inhibit repetitive neuronal firing.2015

    • Author(s)
      Saitsu, H., T. Akita, J. Tohyama, H. Goldberg-Stern, Y. Kobayashi, R. Cohen, M. Kato, C. Ohba, S. Miyatake, Y. Tsurusaki, M. Nakashima, N. Miyake, A. Fukuda, and N. Matsumoto
    • Journal Title

      Sci Rep

      Volume: 5 Issue: 1 Pages: 15199-15199

    • DOI

      10.1038/srep15199

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] De novo DNM1 mutations in two cases of epileptic encephalopathy.2015

    • Author(s)
      Nakashima M, Kouga T, Lourenço CM, Shiina M, Goto T, Tsurusaki Y, Miyatake S, Miyake N, Saitsu H, Ogata K, Osaka H, Matsumoto N.
    • Journal Title

      Epilepsia

      Volume: Epub 2015 Nov 27. Issue: 1

    • DOI

      10.1111/epi.13257

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] Virtual-system coupled adaptive umbrella sampling to compute free-energy landscape for flexible molecular docking2015

    • Author(s)
      Higo J, Dasgupta B, Mashimo T, Kasahara K, Fukunishi Y, Nakamura H
    • Journal Title

      Journal of Computational Chemistry

      Volume: 36 Issue: 20 Pages: 1489-1501

    • DOI

      10.1002/jcc.23948

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Computational Study of Drug Binding Affinity to Influenza A Neuraminidase Using Smooth Reaction Path Generation (SRPG) Method2015

    • Author(s)
      Nguyen H, Tran T, Fukunishi Y, Higo J, Nakamura H, Le L
    • Journal Title

      Journal of Chemical Information and Modeling

      Volume: 55 Issue: 9 Pages: 1936-1943

    • DOI

      10.1021/acs.jcim.5b00319

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] SV40 VP1 major capsid protein in its self-assembled form allows VP1 pentamers to coat various types of artificial beads in vitro regardless of their sizes and shapes2015

    • Author(s)
      M.-A. Kawano, K. Doi, H. Fukuda, Y. Kita, K. Imai, T. Inoue, T. Enomoto, M. Matsui, M. Hatakeyama, Y. Yamaguchi, H. Handa
    • Journal Title

      Biotechnol. Rep.

      Volume: 5 Pages: 105-111

    • DOI

      10.1016/j.btre.2014.12.008

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Phosphatase protection assay: 14-3-3 binding protects the phosphate group of RSG from λ protein phosphatase2015

    • Author(s)
      Ito, T. and Takahashi, Y.
    • Journal Title

      Bio-Protocol

      Volume: 5

    • Related Report
      2014 Annual Research Report
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  • [Journal Article] Identification of diphtheria toxin R domain mutants with enhanced inhibitory activity against HB-EGF2015

    • Author(s)
      Suzuki K, Mizushima H, Abe H, Iwamoto R, Nakamura H, Mekada E
    • Journal Title

      J Biochem

      Volume: mvu079 Issue: 5 Pages: 331-343

    • DOI

      10.1093/jb/mvu079

    • NAID

      40020461422

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] A Japanese girl with an early-infantile onset vanishing white matter disease resembling Cree leukoencephalopathy.2014

    • Author(s)
      Takano K, Tsuyusaki Y, Sato M, Takagi M, Anzai R, Okuda M, Iai M, Yamashita S,
    • Journal Title

      Brain Dev.

      Volume: 37(6) Issue: 6 Pages: 638-42

    • DOI

      10.1016/j.braindev.2014.10.002

    • Related Report
      2015 Annual Research Report
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  • [Journal Article] Dominant mutations in ORAI1 cause tubular-aggregate-myopathy with hypocalcemia by constitutive activation of store-operated Ca2+ channel2014

    • Author(s)
      Endo Y, Noguchi S, Hara Y, Hayashi YK, Motomura K, Murakami N, Tanaka S, Yamashita S, Kizu R, Bamba M, Goto Y, Matsumoto N, Nonaka I, Nishino I.
    • Journal Title

      Hum Mol Genet

      Volume: 24(3) Issue: 3 Pages: 637-648

    • DOI

      10.1093/hmg/ddu477

    • Related Report
      2015 Annual Research Report 2014 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Identification and in vivo functional characterization of novel compound heterozygous BMP1 variants in osteogenesis imperfecta.2014

    • Author(s)
      Cho SY, Asharani PV, Kim OH, Iida A, Miyake N, Matsumoto N, Nishimura G, Ki CS, Hong G, Kim SJ, Sohn YB, Park SW, Lee J, Kwun Y, Carney TJ, Huh R, Ikegawa S, Jin DK.
    • Journal Title

      Hum Mutat

      Volume: 36(2) Issue: 2 Pages: 191-5

    • DOI

      10.1002/humu.22731

    • Related Report
      2015 Annual Research Report 2014 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] DSIF and NELF interact with Integrator to specify the correct post-transcriptional fate of snRNA genes2014

    • Author(s)
      J. Yamamoto, Y. Hagiwara, K. Chiba, T. Isobe, T. Narita, H. Handa, Y. Yamaguchi
    • Journal Title

      Nat. Commun.

      Volume: 5 Issue: 1 Pages: 4263-4263

    • DOI

      10.1038/ncomms5263

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Inhibition of protein SUMOylation by davidiin, an ellagitannin from Davidia involucrata2014

    • Author(s)
      M. Takemoto, Y. Kawamura, M. Hirohama, Y. Yamaguchi, H. Handa, H. Saitoh, Y. Nakao, M. Kawada, K. Khalid, H. Koshino, K. Kimura, A. Ito, M. Yoshida
    • Journal Title

      J. Antibiot. (Tokyo)

      Volume: 67 Issue: 4 Pages: 335-338

    • DOI

      10.1038/ja.2013.142

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Magnetically promoted rapid immunoreactions using functionalized fluorescent magnetic beads: A proof of principle2014

    • Author(s)
      S. Sakamoto, K. Omagari, Y. Kita, Y. Mochizuki, Y. Naito, S. Kawata, S. Matsuda, O. Itano, H. Jinno, H. Takeuchi, Y. Yamaguchi, Y. Kitagawa, H. Handa
    • Journal Title

      Clin Chem.

      Volume: 60 Issue: 4 Pages: 610

    • DOI

      10.1373/clinchem.2013.211433

    • URL

      https://pure.teikyo.jp/en/publications/18ea63f4-cb9b-4398-88f0-548212ebe312

    • Related Report
      2014 Annual Research Report 2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Scaffold function of Ca2+-dependent protein kinase: NtCDPK1 transfers 14-3-3 to the substrate RSG after phosphorylation2014

    • Author(s)
      Ito T, Nakata M, Fukazawa J, Ishida S, Takahashi Y.
    • Journal Title

      Plant Physiol.

      Volume: 165 Issue: 4 Pages: 1737-1750

    • DOI

      10.1104/pp.114.236448

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] DELLAs function as coactivators of GAI ASSOCIATED FACTOR1 in regulation of GA homeostasis and signaling in Arabidopsis2014

    • Author(s)
      Fukazawa J, Teramura H, Murakoshi S, Nasuno K, Nishida N, Ito T, Yoshida M, Kamiya Y, Yamaguchi S, Takahashi Y.
    • Journal Title

      Plant Cell

      Volume: 26 Issue: 7 Pages: 2920-2938

    • DOI

      10.1105/tpc.114.125690

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Phosphorylation-independent binding of 14-3-3 to NtCDPK1 by a new mode2014

    • Author(s)
      Ito T, Nakata M, Fukazawa J, Ishida S, Takahashi Y.
    • Journal Title

      Plant Signal Behav.

      Volume: 9 Issue: 12 Pages: e977721-e977721

    • DOI

      10.4161/15592324.2014.977721

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Crystallization of the Ets1-Runx1-CBFβ-DNA complex formed on the TCRα gene enhancer2014

    • Author(s)
      Shiina M, Hamada K, Inoue-Bungo T, Shimamura M, Baba S, Sato K, Ogata K
    • Journal Title

      Acta Crystallogr F Struct Biol Commun

      Volume: 70 Issue: 10 Pages: 1380-1384

    • DOI

      10.1107/s2053230x14018470

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] A hemizygous GYG2 mutation and Leigh syndrome: a possible link?2014

    • Author(s)
      Imagawa E, Osaka H, Yamashita A, Shiina M, Takahashi E, Sugie H, Nakashima M, Tsurusaki Y, Saitsu H, Ogata K, Matsumoto N, Miyake N.
    • Journal Title

      Hum Genet.

      Volume: 133(2 Issue: 2 Pages: 225-34

    • DOI

      10.1007/s00439-013-1372-6

    • Related Report
      2014 Annual Research Report 2013 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Regulation of RNA polymerase II activation by histone acetylation in single living cells2014

    • Author(s)
      Stasevich TJ, Hayashi-Takanaka Y, Sato Y, Maehara K, Ohkawa Y, Sakata-Sogawa K, Tokunaga M, Nagase T, Nozaki N, McNally JG, Kimura H
    • Journal Title

      Nature

      Volume: 516 Issue: 7530 Pages: 272-275

    • DOI

      10.1038/nature13714

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] A Facile Preparation of Glass-supported Lipid Bilayers for Analyzing Molecular Dynamics2014

    • Author(s)
      Yuma Ito, Kumiko Sakata-Sogawa, Makio Tokunaga
    • Journal Title

      Analytical Sciences

      Volume: 30 Issue: 12 Pages: 1103-1106

    • DOI

      10.2116/analsci.30.1103

    • NAID

      130004704345

    • ISSN
      0910-6340, 1348-2246
    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Nuclear actin activates human transcription factor genes including the OCT4 gene2014

    • Author(s)
      Yamazaki S., Yamamoto K., Tokunaga M., Sakata-Sogawa K., Harata M.
    • Journal Title

      Biosci Biotechnol Biochem

      Volume: 79 Pages: 242-246

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Clinical exome sequencing in neurology practice2014

    • Author(s)
      Miyatake S,Matsumoto N.
    • Journal Title

      Nat Rev Neurol

      Volume: 10(12) Issue: 12 Pages: 676-678

    • DOI

      10.1038/nrneurol.2014.213

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] De novo SOX11 mutations cause Coffin-Siris syndrome2014

    • Author(s)
      Tsurusaki Y, Ohashi H, Phadke S, Koshimizu E, Kou I, Shiina M, Suzuki T, Okamoto N, Imamura S, Yamashita M, Watanabe S, Yoshiura K-i, Kodera H, Miyatake S, Nakashima N, Saitsu H, Ogata K, Ikegawa S, Miyake N, and Matsumoto N.
    • Journal Title

      Nat Commun

      Volume: 5 Issue: 1 Pages: 4011-4011

    • DOI

      10.1038/ncomms5011

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Expanding the phenotypic spectrum of TUBB4A-associated2014

    • Author(s)
      Miyatake S, Osaka H, Shiina M, Sasaki M, Takanashi J, Haginoya K, Wada T,
    • Journal Title

      Neurology

      Volume: 82(24) Issue: 24 Pages: 2230-7

    • DOI

      10.1212/wnl.0000000000000535

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] PIGA mutations cause early-onset epileptic encephalopathies and distinctive features2014

    • Author(s)
      Kato M, Saitsu H, Murakami Y , Kikuchi K, Watanabe S, Iai M, Miya K, Matsuura R, Takayama R, Ohba C, Nakashima M, Tsurusaki Y, Miyake N, Hamano S, Osaka H, Hayasaka K, Kinoshita T, Matsumoto N.
    • Journal Title

      Neurology

      Volume: 82(18) Issue: 18 Pages: 1587-1596

    • DOI

      10.1212/wnl.0000000000000389

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] AKT3 and PIK3R2 mutations in two patients with megalencephaly-related syndromes2014

    • Author(s)
      Nakamura K, Kato M, Tohyama J, Shiohama T, Hayasaka K, Nishiyama K, Kodera H, Nakashima M, Tsurusaki Y, Miyake N, Matsumoto N, Saitsu H.
    • Journal Title

      Clin Genet

      Volume: 85(4) Issue: 4 Pages: 396-398

    • DOI

      10.1111/cge.12188

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] PIGN mutations cause congenital anomalies, developmental delay, hypotonia, epilepsy, and progressive cerebellar atrophy2014

    • Author(s)
      Ohba C, Okamoto N, Murakami Y, Kawato K, Suzuki Y, Ikeda T, Tsurusaki Y, Nakashima M, Miyake N, Tanaka F, Kinoshita T, Matsumoto N, Saitsu H .
    • Journal Title

      Neurogenet

      Volume: 15(2) Issue: 2 Pages: 85-92

    • DOI

      10.1007/s10048-013-0384-7

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Early onset epileptic encephalopathy caused by de novo SCN8A mutations2014

    • Author(s)
      Ohba C, Kato M, Takahashi S, Lerman-Sagie T, Lev D, Terashima H, Kubota M, Kawawaki H, Matsufuji M, Kojima Y, Tateno A, Goldberg-Stern H, Straussberg R, Marom D, Leshinsky-Silver E, Nakashima M, Nishiyama K, Tsurusaki Y, Miyake N, Tanaka F, Matsumoto N, Saitsu H:
    • Journal Title

      Epilepsia

      Volume: 55 Issue: 7 Pages: 994-1000

    • DOI

      10.1111/epi.12668

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed
  • [Journal Article] De novo WDR45 mutation in a patient showing clinically Rett syndrome with childhood iron deposition in brain2014

    • Author(s)
      Ohba C, Nabatame S, Iijima Y, Nishiyama K, Tsurusaki Y, Nakashima M, Miyake N, Tanaka F, Ozono K, Saitsu H, Matsumoto N.
    • Journal Title

      J Hum Genet

      Volume: 59(5) Issue: 5 Pages: 292-295

    • DOI

      10.1038/jhg.2014.18

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Deep sequencing detects very low-grade somatic mosaicism in the unaffected mother of siblings with nemaline myopathy2014

    • Author(s)
      Miyatake S, Koshimizu E, Hayashi YK, Miya K, Shiina M, Nakashima M, Tsurusaki Y, Miyake N, Saitsu H, Ogata K, Nishino I, Matsumoto N.
    • Journal Title

      Neuromuscul Disord

      Volume: 24(7) Issue: 7 Pages: 642-647

    • DOI

      10.1016/j.nmd.2014.04.002

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Novel compound heterozygous PIGT mutations caused multiple congenital anomalies-hypotonia-seizures syndrome 32014

    • Author(s)
      Nakashima M, Kashii H, Murakami Y, Kato M, Tsurusaki Y, Miyake N, Kubota M, Kinoshita T, Saitsu H, Matsumoto N.
    • Journal Title

      Neurogenet

      Volume: 15(3) Issue: 3 Pages: 193-200

    • DOI

      10.1007/s10048-014-0408-y

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Numerous BAF complex genes are mutated in Coffin-Siris syndrome2014

    • Author(s)
      Miyake N, Tsurusaki Y, Matsumoto N.
    • Journal Title

      Am J Med Genet Part C

      Volume: 166c(3) Issue: 3 Pages: 257-261

    • DOI

      10.1002/ajmg.c.31406

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Causative novel PNKP mutations and concomitant PCDH15 mutations in a patient with microcephaly with early-onset seizures and developmental delay syndrome and hearing loss2014

    • Author(s)
      Nakashima M, Takano K, Osaka H, Aida N, Tsurusaki Y, Miyake N, Saitsu H, Matsumoto N.
    • Journal Title

      J Hum Genet

      Volume: 59(8) Issue: 8 Pages: 471-474

    • DOI

      10.1038/jhg.2014.51

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Whole exome analysis identifies frequent CNGA1 mutations in Japanese population with autosomal recessive retinitis pigmentosa2014

    • Author(s)
      Katagiri S, Akahori M, Sergeev Y, Yoshitake K, Ikeo K, Furuno M, Hayashi T, Kondo M, Ueno S, Tsunoda K, Shinoda K, Kuniyoshi K, Tsurusaki Y, Matsumoto N, Tsuneoka H, Iwata T.
    • Journal Title

      Plos One

      Volume: 9(9) Issue: 9 Pages: e108721-e108721

    • DOI

      10.1371/journal.pone.0108721

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Whole exome sequencing revealed biallelic IFT122 mutations in a family with CED1 and recurrent pregnancy loss.2014

    • Author(s)
      Tsurusaki Y, Yonezawa R, Furuya M, Nishimura G, Pooh R, Nakashima M, Saitsu H, Miyake N, Saito S, Matsumoto N.
    • Journal Title

      Clin Genet.

      Volume: 85 Issue: 6 Pages: 592-594

    • DOI

      10.1111/cge.12215

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Coffin-Siris syndrome is a SWI/SNF complex disorder2014

    • Author(s)
      Tsurusaki Y, Okamoto N, Ohashi H, Mizuno S, Matsumoto N, Makita Y, Fukuda M, Isidor B, Perrier J, Aggarwal S, Al-Kindy A, Liebelt J, Mowat D, Nakashima M, Saitsu H, Miyake N, Matsumoto N.
    • Journal Title

      Clin Genet

      Volume: 85(6) Issue: 6 Pages: 548-554

    • DOI

      10.1111/cge.12225

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] De novo EEF1A2 mutations in patients with characteristic facial features, intellectual disability and, autistic behaviors and epilepsy2014

    • Author(s)
      Nakajima J, Okamoto N, Tohyama J, Kato M, Arai H, Funahashi O, Tsurusakia Y, Nakashima M, Kawashima H, Saitsu H, Matsumoto N, Miyake N.
    • Journal Title

      Clin Genet

      Volume: 87(4) Issue: 4 Pages: 356-361

    • DOI

      10.1111/cge.12394

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Late-onset spastic ataxia phenotype in a patient with a homozygous DDHD2 mutation2014

    • Author(s)
      Doi H, Ushiyama M, Baba T, Tani K, Shiina M, Ogata K, Miyatake S, Yuzawa YF, Tsuji S, Nakashima M, Tsurusaki Y, Miyake N, Saitsu H, Ikeda S, Tanaka F, Matsumoto N, Yoshida K
    • Journal Title

      Sci Rep

      Volume: 4 Issue: 1 Pages: 7132-7132

    • DOI

      10.1038/srep07132

    • NAID

      120007100602

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Atypical giant axonal neuropathy arising from a homozygous mutation by uniparental isodisomy2014

    • Author(s)
      Miyatake S, Koshimizu E, Tada H, Satoshi Moriya S, Takanashi J, Hirano Y, Hayashi M, Nakashima M, Tsurusaki Y, Miyake N, Matsumoto N, Saitsu H.
    • Journal Title

      Clin Genet

      Volume: 87(4) Issue: 4 Pages: 395-397

    • DOI

      10.1111/cge.12455

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] High-resolution modeling of antibody structures by a combination of bioinformatics, expert knowledge, and molecular simulations.2014

    • Author(s)
      Hiroki Shirai, Kazuyoshi Ikeda, Kazuo Yamashita, Yuko Tsuchiya, Jamica Sarmiento, Shide Liang, Tatsuaki Morokata, Kenji Mizuguchi, Junichi Higo, Daron M. Standley, Haruki Nakamura
    • Journal Title

      Proteins

      Volume: 印刷中 Issue: 8 Pages: 1624-1635

    • DOI

      10.1002/prot.24591

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] The Zero-multipole summation method for estimating electrostatic interactions in molecular dynamics : analysis of the accuracy and application to liquid systems2014

    • Author(s)
      Fukuda I, Kamiya N, Nakamura H
    • Journal Title

      J. Chem. Phys

      Volume: 140 Issue: 19 Pages: 194307-194307

    • DOI

      10.1063/1.4875693

    • NAID

      120005596268

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] 3D flexible alignment using 2D maximum common substructure: dependence of prediction accuracy on target-reference chemical similarity2014

    • Author(s)
      Takeshi Kawabata, Haruki Nakamura
    • Journal Title

      Journal of Chemical Information and Modeling

      Volume: 54 (7) Issue: 7 Pages: 1850-1863

    • DOI

      10.1021/ci500006d

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Structure of the entire stalk region of the dynein motor domain2014

    • Author(s)
      Yosuke Nishikawa, Takuji Oyama, Narutoshi Kamiya, Takahide Kon, Yoko Y. Toyoshima, Haruki Nakamura, Genji Kurisu
    • Journal Title

      Journal of Molecular Biology

      Volume: 426 Issue: 19 Pages: 3232-3245

    • DOI

      10.1016/j.jmb.2014.06.023

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Kotai Antibody Builder: Automated, high-resolution structural modeling of antibodies2014

    • Author(s)
      Kazuo Yamashita, Kazuyoshi Ikeda, Karlou Amada, Shide Liang, Yuko Tsuchiya,Haruki Nakamura, Hiroki Shirai, Daron M Standley
    • Journal Title

      Bioinformatics

      Volume: 30 (22) Pages: 3279-3280

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed
  • [Journal Article] A Novel Approach of Dynamic Cross Correlation Analysis on Molecular Dynamics Simulations and its Application to Ets1 dimer–DNA Complex2014

    • Author(s)
      Kota Kasahara, Ikuo Fukuda, Haruki Nakamura
    • Journal Title

      PLoS One

      Volume: 9 (11) Issue: 11 Pages: e112419-e112419

    • DOI

      10.1371/journal.pone.0112419

    • NAID

      120005596267

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] The specification and global reprogramming of histone epigenetic marks during gamete formation and early embryo development in C. elegans2014

    • Author(s)
      Samson M, Jow MM, Wong CC, Fitzpatrick C, Aslanian A, Saucedo I, Estrada R, Ito T, Park SK, Yates JR, Chu, DS
    • Journal Title

      PLoS Genet

      Volume: 10 Issue: 10 Pages: e1004588-e1004588

    • DOI

      10.1371/journal.pgen.1004588

    • NAID

      120006986360

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Characterization of nuclear pore complex components in fission yeast Schizosaccharomyces pombe2014

    • Author(s)
      Asakawa H, Yang HJ, Yamamoto T G, Ohtsuki C, Chikashige Y, Sakata-Sogawa K, Tokunaga M, Iwamoto M, Hiraoka Y, Haraguchi T.
    • Journal Title

      Nucleus

      Volume: 5(印刷中) Issue: 2 Pages: 1-14

    • DOI

      10.4161/nucl.28487

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Scaffold function of Ca2+-dependent protein kinase: NtCDPK1 transfers 14-3-3 to the substrate RSG after phosphorylation2014

    • Author(s)
      Ito, T., Nakata, M., Fukazawa, J., Ishida, S. and Takahashi, Y.
    • Journal Title

      Plant Physiol.

      Volume: in press

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Vesnarinone Suppresses TNF α mRNA Expression by Inhibiting Valosin-containing Protein2013

    • Author(s)
      Hotta K, Nashimoto A, Yasumura E, Suzuki M, Azuma M, Iizumi Y, Shima D, Nabeshima R, Hiramoto M, Okada A, Sakata-Sogawa K, Tokunaga M, Ito T, Ando H, Sakamoto S, Kabe Y, Aizawa S, Imai T, Yamaguchi Y, Watanabe H, Handa H
    • Journal Title

      Mol Pharmacol

      Volume: Vol.83 Issue: 5 Pages: 930-938

    • DOI

      10.1124/mol.112.081935

    • Related Report
      2013 Annual Research Report 2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Viral protein-coating of magnetic nanoparticles using simian virus 40 VP12013

    • Author(s)
      T. Enomoto, M.-A. Kawano, H. Fukuda, W. Sawada, T. Inoue, K. C. Haw, Y. Kita, S. Sakamoto, Y. Yamaguchi, T. Imai, M. Hatakeyama, S. Saito, A. Sandhu, M. Matsui, I. Aoki, H. Handa
    • Journal Title

      J. Biotechnol.

      Volume: 167 Issue: 1 Pages: 8-15

    • DOI

      10.1016/j.jbiotec.2013.06.005

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Activation-induced cytidine deaminase auto-activates and triggers aberrant gene expression2013

    • Author(s)
      Isobe, T., Song, S.-N. J., Tiwari, P., Ito, H., Yamaguchi, Y., and Yoshizaki, K.
    • Journal Title

      FEBS Letters

      Volume: 587 Issue: 16 Pages: 2487-2492

    • DOI

      10.1016/j.febslet.2013.06.028

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Salicylic acid induces mitochondrial injury by inhibiting ferrochelatase heme biosynthesis activity2013

    • Author(s)
      V. Gupta, S. Liu, H. Ando, R. Ishii, S. Tateno, Y. Kaneko, M. Yugami, S. Sakamoto, Y. Yamaguchi, O. Nureki, H. Handa
    • Journal Title

      Mol. Pharmacol.

      Volume: 84 Issue: 6 Pages: 824-833

    • DOI

      10.1124/mol.113.087940

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Mitochondrial complex III deficiency caused by a homozygous UQCRC2 mutation presenting with neonatal-onset recurrent metabolic decompensation2013

    • Author(s)
      Miyake N^<#>, Yano S^<#> (# denotes equal contribution), Sakai C, Hatakeyama H, Shiina M, Watanabe Y, Bartley J, Abdenur JE, Wang RY, Chang R, Tsurusaki Y, Doi H, Saitsu H, Ogata K, Goto Y, *Matsumoto N
    • Journal Title

      Hum Mut

      Volume: 34(3):446-452 Issue: 3 Pages: 446-452

    • DOI

      10.1002/humu.22257

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Exome sequencing identifies a novel INPPL1 mutation in opsismodysplasia2013

    • Author(s)
      Iida A, Okamoto N, Miyake N, Nishimura G, Minami S, Sugimoto T, Nakashima M, Tsurusaki Y, Saitsu H, Shiina M, Ogata K, Watanabe S, Ohashi H, Matsumoto N, Ikegawa S
    • Journal Title

      J Hum Genet

      Volume: 58 Issue: 6 Pages: 391-394

    • DOI

      10.1038/jhg.2013.25

    • NAID

      10031184228

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Identification of KLHL41 mutations implicates BTB-Kelch-mediated ubiquitination as an alternate pathway to myofibrillar disruption in nemaline myopathy2013

    • Author(s)
      Gupta V, Shiina M, Ogata K, Matsumoto N, Beggs N et al.
    • Journal Title

      Am J Hum Genet

      Volume: 93 Issue: 6 Pages: 1108-1117

    • DOI

      10.1016/j.ajhg.2013.10.020

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Mutations in KLHL40 are a frequent cause of severe autosomal-recessive nemaline myopathy2013

    • Author(s)
      Ravenscroft G, Ogata K, Shiina M, Matsumoto N, Laing NG et al.
    • Journal Title

      Am J Hum Genet

      Volume: 93 Issue: 1 Pages: 6-18

    • DOI

      10.1016/j.ajhg.2013.05.004

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] De Novo Mutations in GNAO1, Encoding a Gαo Subunit of Heterotrimeric G Proteins, Cause Epileptic Encephalopathy.2013

    • Author(s)
      Nakamura, K., et al.,
    • Journal Title

      Am. J. Hum. Genet.

      Volume: 93 Issue: 3 Pages: 496-505

    • DOI

      10.1016/j.ajhg.2013.07.014

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] De novo mutations in the autophagy gene WDR45 cause static encephalopathy of childhood with neurodegeneration in adulthood2013

    • Author(s)
      Saitsu H, Nishimura T, Muramatsu K, Kodera H, Kumada S, Sugai K, Kasai-Yoshida E, Sawaura N, Nishida H, Hoshino A, Ryujin F, Yoshioka S, Nishiyama K, Kondo Y, Tsurusaki Y, Nakashima M, Miyake N, Arakawa H, Kato M, Mizushima, Matsumoto N
    • Journal Title

      Nat Genet

      Volume: 45 Issue: 4 Pages: 445-449

    • DOI

      10.1038/ng.2562

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Essential role of the IRF8-KLF4 transcription factor cascade in murine monocyte differentiation.2013

    • Author(s)
      Daisuke Kurotaki et al.
    • Journal Title

      Blood

      Volume: 121 Issue: 10 Pages: 1839-1849

    • DOI

      10.1182/blood-2012-06-437863

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Whole genome sequencing in patients with retinitis pigmentosa reveals pathogenic DNA structural changes and NEK2 as a new disease gene2013

    • Author(s)
      Nishiguchi KM, Tearle RG, Liu YP, Oh EC, Miyake N, Benaglio P, Harper S, Koskiniemi-Kuendig H, Venturini G, Sharon D, Koenekoop RK, Nakamura M, Kondo M, Ueno S, Yasuma TR, Beckmann JS, Ikegawa S, Matsumoto N, Terasaki H, Berson EL, Katsanis N, Rivolta C
    • Journal Title

      Proc Natl Acad Sci U S A

      Volume: 110 Issue: 40 Pages: 16139-16144

    • DOI

      10.1073/pnas.1308243110

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] MLL2 and KDM6A mutations in patients with Kabuki syndrome.2013

    • Author(s)
      Miyake N*, Koshimizu E, Okamoto N, Mizuno S, Ogata T,at all
    • Journal Title

      Am J Med Genet A

      Volume: 161 Issue: 9 Pages: 2234-2243

    • DOI

      10.1002/ajmg.a.36072

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] The USP21 short variant (USP21SV) lacking NES, located mostly in the nucleus in vivo, activates transcription by deubiquitylating ubH2A in vitro2013

    • Author(s)
      Okuda H, Ohdan H, Nakayama M, Koseki H, Nakagawa T, Ito T.
    • Journal Title

      PLoS One

      Volume: 8 Issue: 11 Pages: 1-9

    • DOI

      10.1371/journal.pone.0079813

    • NAID

      120006986685

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] A virtual-system coupled multicanonical molecular dynamics simulation : Principles and applications to free-energy landscape of protein-protein interaction with an all-atom model in explicit solvent2013

    • Author(s)
      J. Higo, K. Umezawa, H. Nakamura
    • Journal Title

      Journal of Chemical Physics

      Volume: 138 Issue: 18 Pages: 184106-184106

    • DOI

      10.1063/1.4803468

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] LigandBox: A database for 3D structures of chemical compounds2013

    • Author(s)
      Takeshi Kawabata, Yusuke Sugihara, Yoshifumi Fukunishi, Haruki Nakamura
    • Journal Title

      BIOPHYSICS

      Volume: 9 Issue: 0 Pages: 113-121

    • DOI

      10.2142/biophysics.9.113

    • NAID

      130003366038

    • ISSN
      1349-2942
    • Related Report
      2013 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Exhaustive comparison and classification of ligand-binding surfaces in proteins2013

    • Author(s)
      Murakami Y, Kinoshita K, Kinjo AR, Nakamura H
    • Journal Title

      Protein Science

      Volume: 22 Issue: 10 Pages: 1379-1391

    • DOI

      10.1002/pro.2329

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Molecular dynamics simulations of a double-stranded DNA in an explicit solvent model with zero-dipole summation method2013

    • Author(s)
      Arakawa T, Kamiya N, Nakamura H, Fukuda I
    • Journal Title

      PLoS ONE

      Volume: 8 Issue: 10 Pages: e76606-e76606

    • DOI

      10.1371/journal.pone.0076606

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Vitamin K2 covalently binds to Bak and induces Bak-mediated apoptosis.2013

    • Author(s)
      Karasawa S, Azuma M, Kasama T, Sakamoto S, Kabe Y, Imai T, Yamaguchi Y, Miyazawa K, Handa H
    • Journal Title

      Mol Pharmacol

      Volume: 83 Issue: 3 Pages: 613-620

    • DOI

      10.1124/mol.112.082602

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] NYC4, the rice ortholog of Arabidopsis THF1, is involved in the degradation of chlorophyll-protein complexes during leaf senescence.2013

    • Author(s)
      Yamatani, H.
    • Journal Title

      Plant J.

      Volume: 74 Issue: 4 Pages: 652-662

    • DOI

      10.1111/tpj.12154

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Application of zero-dipole summation method to molecular dynamics2013

    • Author(s)
      Narutoshi Kamiya
    • Journal Title

      Chem. Phys. Lett.

      Volume: 568-569 Pages: 26-32

    • DOI

      10.1016/j.cplett.2013.03.014

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] NF-E2 p45 activates genes involved in the regulation of platelet function2013

    • Author(s)
      Fujita, R.
    • Journal Title

      Molecular and Cellular Biology

      Volume: 印刷中

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] KDM6A point mutations cause Kabuki syndrome2012

    • Author(s)
      Miyake N, Mizuno S, Okamoto N, Ohashi H, Shiina M, Ogata K, Tsurusaki Y, Nakashima M, Saitsu H, *Matsumoto N (*: co-corresponding)
    • Journal Title

      Hum Mut

      Volume: 34(1):108-110 Issue: 1 Pages: 108-110

    • DOI

      10.1002/humu.22229

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Systematic changes to the apparent diffusion tensor of in vivo rat brain measured with an oscillating-gradient spin-echo sequence.2012

    • Author(s)
      Kershaw J, Leuze C, Aoki I, Obata I, Kanno I, Ito H, Yamaguchi Y, Handa H.
    • Journal Title

      Neuroimage.

      Volume: 70 Pages: 10-20

    • DOI

      10.1016/j.neuroimage.2012.12.036

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Identification of DNA-dependent protein kinase catalytic subunit (DNA-PKcs) as a novel target of Bisphenol A.2012

    • Author(s)
      Ito, Y., Ito, T., Karasawa, S., Enomoto, T., Nashimoto, A., Hase, Y., Sakamoto, S., Ito, T., Mimori, T., Matsumoto, Y., Yamaguchi, Y., Handa, H.
    • Journal Title

      PLos ONE

      Volume: 7(12) Issue: 12 Pages: e50481-e50481

    • DOI

      10.1371/journal.pone.0050481

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] DSIF restricts NF-kappa B signaling by coordinating elongation with mRNA Processing of negative feedback genes2012

    • Author(s)
      Diamant, G.
    • Journal Title

      Cell Reports

      Volume: 2 Issue: 4 Pages: 722-731

    • DOI

      10.1016/j.celrep.2012.08.041

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Transcription elongation factors DSIF and NELF: promoter-proximal pausing and beyond2012

    • Author(s)
      Yamaguchi, Y.
    • Journal Title

      Biochim. Biophys. Acta

      Volume: 1829 Issue: 1 Pages: 98-104

    • DOI

      10.1016/j.bbagrm.2012.11.007

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Histone H2A Mono-Ubiquitination Is a Crucial Step to Mediate PRC1-Dependent Repression of Developmental Genes to Maintain ES Cell Identity.2012

    • Author(s)
      Endoh M, Endo TA, Endoh T, Isono K, Sharif J, Ohara O, Toyoda T, Ito T, Eskeland R, Bickmore WA, Vidal M, Bernstein BE, Koseki H.
    • Journal Title

      PLoS Genet.

      Volume: 8 Issue: 7 Pages: e1002774-e1002774

    • DOI

      10.1371/journal.pgen.1002774

    • NAID

      120006985569

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Histone Monoubiquitylation Position Determines Specificity and Direction of Enzymatic Cross-talk with Histone Methyltransferases Dot1L and PRC2.2012

    • Author(s)
      Whitcomb, S.J., Fierz, B., McGinty, R.K., Holt, M., Ito, T., Muir, T.W., and Allis, C.D.
    • Journal Title

      J Biol Chem

      Volume: 287 Issue: 28 Pages: 23718-23725

    • DOI

      10.1074/jbc.m112.361824

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Rapid detection of gene mutations responsible for non-syndromic aortic aneurysm and dissection using two different methods : resequencing microarray technology and next-generation sequencing2012

    • Author(s)
      Sakai H, Suzuki S, Mizuguchi T, Imoto K, Yamashita Y, Doi H, Kikuchi M, Tsurusaki Y, Saitsu H, Miyake N, Masuda M, Matsumoto N
    • Journal Title

      Hum Genet

      Volume: 131巻 Issue: 4 Pages: 591-599

    • DOI

      10.1007/s00439-011-1105-7

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] A family of oculofaciocardiodental syndrome(OFCD) with a novel BCOR mutation and genomic rearrangements involving NHS2012

    • Author(s)
      Kondo Y, Saitsu H, Miyamoto T, Nishiyama K, Tsurusaki Y, Doi H, Miyake N, Ryoo NK, Kim JH, Yu YS, Matsumoto N
    • Journal Title

      J Hum Genet

      Volume: 57巻 Issue: 3 Pages: 197-201

    • DOI

      10.1038/jhg.2012.4

    • NAID

      10030712110

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Missense mutations in the DNA-binding/dimerization domain of NFIX cause Sotos-like features2012

    • Author(s)
      Yoneda Y, Saitsu H, Touyama M, Makita Y, Miyamoto A, Hamada K, Kurotaki N, Tomita H, Nishiyama K, Tsurusaki Y, Doi H, Miyake N, Ogata K, Naritomi K, Matsumoto N
    • Journal Title

      J Hum Genet

      Volume: 57巻 Issue: 3 Pages: 207-211

    • DOI

      10.1038/jhg.2012.7

    • NAID

      10030712151

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] A girl with early-onset epileptic encephalopathy associated with microdeletion involving CDKL52012

    • Author(s)
      *Saitsu H et al.
    • Journal Title

      Brain Dev

      Volume: 34(5):364-7 Issue: 5 Pages: 364-367

    • DOI

      10.1016/j.braindev.2011.07.004

    • NAID

      10031050724

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Homozygous c. 14576G> A Variant of<I> RNF213</I> Predicts Early-Onset and Severe Form of Moyamoya Disease2012

    • Author(s)
      Miyatake S, Miyake N, Touho H, Nishimura-T, A, Kondo Y, Okada ; I, Tsurusaki ; Y, Doi H, Sakai H, Saitsu ; H, Shimojima K, Yamamoto T, Higurashi M, Kawahara, N, Kawauchi, H, Nagasaka, K, Okamoto N, Mori, T, Koyano S, Kuroiwa Y, Taguri M, Morita S, Matsuba S, Kure S, Matsumoto N
    • Journal Title

      Neurology

      Volume: 78(11) Issue: 11 Pages: 803-10

    • DOI

      10.1212/wnl.0b013e318249f71f

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Identification of a novel in-frame de novo mutation in SPTAN1 in intellectual disability and pontocerebellar atrophy2012

    • Author(s)
      Hamdan F, Saitsu H (Co-first Author) et al.
    • Journal Title

      Eur J Hum Genet

      Volume: 20(7):796-800 Issue: 7 Pages: 796-800

    • DOI

      10.1038/ejhg.2011.271

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Association of genomic deletions in the STXBP1 gene with Ohtahara syndrome2012

    • Author(s)
      *Saitsu H et al.
    • Journal Title

      Clinical Genetics

      Volume: 81(4):399-402 Issue: 4 Pages: 86-90

    • DOI

      10.1111/j.1399-0004.2011.01733.x

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Neurodevelopmental features in 2q23.1 microdeletion syndrome: Report of a new patient with intractable seizures and review of literature2012

    • Author(s)
      Motobayashi, M.
    • Journal Title

      Am. J. Med. Genet. Part A

      Volume: 158 Issue: 4 Pages: 861-868

    • DOI

      10.1002/ajmg.a.35235

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Mutations affecting components of the SWI/SNF complex cause Coffin-Siris syndrome2012

    • Author(s)
      Tsurusaki Y, Okamoto N, Ohashi H, Kosho T, Imai Y, Hibi-Ko Y, Kaname T, Naritomi K, Kawame H, Wakui K, Fukushima Y, Homma T, Kato M, Hiraki Y, Yamagata T, Yano S, Mizuno S, Sakazume S, Ishii T, Nagai T, Shiina M, Ogata K, Ohta T, Niikawa N, Miyatake S, Okada I, Mizuguchi T, Doi H, Saitsu H, Miyake N, Matsumoto N
    • Journal Title

      Nat Genet

      Volume: 44 Issue: 4 Pages: 376-378

    • DOI

      10.1038/ng.2219

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Contiguous deletion of SLC6A8 and BAP31 in a patient with severe dystonia and sensorineural deafness2012

    • Author(s)
      Osaka, H.
    • Journal Title

      Mol. Genet. Metab.

      Volume: 106 Issue: 1 Pages: 43-47

    • DOI

      10.1016/j.ymgme.2012.02.018

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Early onset West syndrome with severe hypomyelination and coloboma-like optic discs in a girl with SPTAN1 mutation2012

    • Author(s)
      Writzl K,…Saitsu H.
    • Journal Title

      Epilepsia

      Volume: 53(6):e106-10 Issue: 6

    • DOI

      10.1111/j.1528-1167.2012.03437.x

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Whole exome sequencing identifies KCNQ2 mutations in Ohtahara syndrome2012

    • Author(s)
      *Saitsu H et al.
    • Journal Title

      Ann Neurol

      Volume: 72(2):298-300 Issue: 2 Pages: 298-300

    • DOI

      10.1002/ana.23620

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Diffuse central hypomyelination presenting as4H syndrome caused by compound heterozygous mutations in POLR3A encoding the catalytic subunit of polymerase III.2012

    • Author(s)
      Terao Y, Saitsu H, Segawa M, Kondo Y, Sakamoto K, Matsumoto N et al.
    • Journal Title

      J Neurol Sci

      Volume: 320(1-2) Issue: 1-2 Pages: 102-5

    • DOI

      10.1016/j.jns.2012.07.005

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] CASK aberrations in male patients with Ohtahara syndrome and cerebellar hypoplasia2012

    • Author(s)
      *Saitsu H et al.
    • Journal Title

      Epilepsia

      Volume: 53(8):1441-1449 Issue: 8 Pages: 1441-1449

    • DOI

      10.1111/j.1528-1167.2012.03548.x

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] PAPSS2 mutations cause autosomal recessive brachyolmia2012

    • Author(s)
      Miyake N^<#>, Elcioglu NH^<#> (# denotes equal contribution), Iida A, Isguven P, Dai J, Murakami N, Takamura K, Cho T-J, Kim O-H, Nagai T, Ohashi H, Nishimura G, Matsumoto N, Ikegawa S
    • Journal Title

      J Med Genet

      Volume: 49(8): 533-538 Issue: 8 Pages: 533-538

    • DOI

      10.1136/jmedgenet-2012-101039

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] A novel SACS mutation in a Japanese family with atypical phenotype of autosomal recessive spastic ataxia of Charlevoix-Saguenay (ARSACS)2012

    • Author(s)
      Miyatake, S.
    • Journal Title

      Intern. Med.

      Volume: 51 Pages: 2221-2226

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] A DYNC1H1 mutation causes a dominant spinal muscular atrophy with lower extremity.2012

    • Author(s)
      Tsurusaki Y, Saitoh S, Tomizawa K, Sudo A, Asahina N, Shiraishi H, Ito J, Tanaka H, Doi H, Saitsu H, Miyake N, Matsumoto N.
    • Journal Title

      Neurogenetics.

      Volume: 13 Issue: 4 Pages: 327-332

    • DOI

      10.1007/s10048-012-0337-6

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Simple and Accurate Scheme to Compute Electrostatic Interactions: Zero-dipole Summation Technique for Molecular System and Application to Bulk Water.2012

    • Author(s)
      Ikuo Fukuda, Narutoshi Kamiya, Yasushige Yonezawa, Haruki Nakamura
    • Journal Title

      Journal of Chemical Physics

      Volume: 137 Issue: 5 Pages: 54314-54314

    • DOI

      10.1063/1.4739789

    • NAID

      120005647641

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Non-Ewald methods : Theory and Applications to Molecular Systems2012

    • Author(s)
      Fukuda I, Nakamura H
    • Journal Title

      Biophysical Reviews

      Volume: 4 Issue: 3 Pages: 161-170

    • DOI

      10.1007/s12551-012-0089-4

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] De Novo and Inherited Mutations in COL4A2, Encoding the Type IV Collagen alpha2 Chain Cause Porencephaly2011

    • Author(s)
      Yoneda Y, et al.
    • Journal Title

      Am J Hum Genet

      Volume: 90 Issue: 1 Pages: 86-90

    • DOI

      10.1016/j.ajhg.2011.11.016

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Presentation] GAF1 とその相互作用因子によるジベレリン生合成酵素遺伝転写制御(優秀発表賞受賞)2017

    • Author(s)
      勝部隆義,伊藤岳,深澤壽太郎,高橋陽介
    • Organizer
      第74回中国四国植物学会
    • Place of Presentation
      高知大学(高知県高知市)
    • Year and Date
      2017-05-14
    • Related Report
      2016 Annual Research Report
  • [Presentation] ホメオドメインタンパク質によるジベレリン生合成遺伝子の転写制御機構の解析2017

    • Author(s)
      中村駿志,深澤壽太郎,高橋陽介
    • Organizer
      第74回中国四国植物学会
    • Place of Presentation
      高知大学(高知県高知市)
    • Year and Date
      2017-05-13
    • Related Report
      2016 Annual Research Report
  • [Presentation] ジベレリンによるシロイヌナズナの花成制御(優秀発表賞受賞)2017

    • Author(s)
      大橋由紀,髙橋竜平,伊藤岳,深澤壽太郎,高橋陽介
    • Organizer
      第74回中国四国植物学会
    • Place of Presentation
      高知大学(高知県高知市)
    • Year and Date
      2017-05-13
    • Related Report
      2016 Annual Research Report
  • [Presentation] DELLA を介したジベレリンとジャスモン酸のクロストーク制御2017

    • Author(s)
      森 亮太,藤井麻耶,伊藤 岳,深澤壽太郎,高橋陽介
    • Organizer
      第74回中国四国植物学会
    • Place of Presentation
      高知大学(高知県高知市)
    • Year and Date
      2017-05-13
    • Related Report
      2016 Annual Research Report
  • [Presentation] Search for anti-leukemic drugs targeting the transcription factor Runx1 by INTENDD2017

    • Author(s)
      Shiina M, Baba S, Uchiyama A, Okada C, Tanaka T, Ikeda K, Kawakita S, Matsuzaki T, Komatsu H, Hosoda M, Ogata K
    • Organizer
      The 137th Annual Meeting of the Pharmaceutical Society of Japan, 3rd International Symposium for Medicinal Sciences
    • Place of Presentation
      仙台国際センター・東北大学川内北キャンパス(宮城県仙台市)
    • Year and Date
      2017-03-24
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] ジベレリン信号伝達におけるDELLA-GAF1複合体による新たな標的遺伝子の制御2017

    • Author(s)
      深澤壽太郎、大橋由紀、森亮太、高橋陽介
    • Organizer
      日本植物生理学会 第58回年会
    • Place of Presentation
      鹿児島大学(鹿児島県鹿児島市)
    • Year and Date
      2017-03-17
    • Related Report
      2016 Annual Research Report
  • [Presentation] 細胞分化における核内アクチンの機能解析2017

    • Author(s)
      横山吟司, 山本浩志, 山崎祥他, 十川久美子, 徳永万喜洋, 原田昌彦
    • Organizer
      日本農芸化学会2017年度大会
    • Place of Presentation
      京都女子大学(京都府京都市)
    • Year and Date
      2017-03-17
    • Related Report
      2016 Annual Research Report
  • [Presentation] 抗炎症薬サリチル酸が示す生体内作用メカニズムの解析2017

    • Author(s)
      坂本 聡、Gupta Vipul、劉 舒捷、安藤秀樹、舘野峻平、金子裕生、湯上真人、石井亮平、濡木 理、山口雄輝、半田 宏
    • Organizer
      日本化学会第97春季年会
    • Place of Presentation
      慶應義塾大学(神奈川県横浜市)
    • Year and Date
      2017-03-16
    • Related Report
      2016 Annual Research Report
  • [Presentation] RNAポリメラーゼⅡ転写産物の長さを決める3’末端プロセシングの制御メカニズムの解明2017

    • Author(s)
      瑞慶覧 安里、舘野 峻平、山本 淳一、山口 雄輝
    • Organizer
      新学術領域研究「転写サイクル」冬の若手ワークショップ2017
    • Place of Presentation
      一宮シーサイドオーツカ(千葉県一宮町)
    • Year and Date
      2017-01-30
    • Related Report
      2016 Annual Research Report
  • [Presentation] マウスES細胞における2細胞期特異的な遺伝子の発現制御メカニズムの解析2017

    • Author(s)
      鈴木 翔子、柴田 紘孝、山口 雄輝
    • Organizer
      新学術領域研究「転写サイクル」冬の若手ワークショップ2017
    • Place of Presentation
      一宮シーサイドオーツカ(千葉県一宮町)
    • Year and Date
      2017-01-30
    • Related Report
      2016 Annual Research Report
  • [Presentation] E3ユビキチンリガーゼCRBNの細胞内局在が免疫調整薬IMiDsの薬効に及ぼす影響2017

    • Author(s)
      徳山 遥香、片山 美樹、山口 雄輝
    • Organizer
      新学術領域研究「転写サイクル」冬の若手ワークショップ2017
    • Place of Presentation
      一宮シーサイドオーツカ(千葉県一宮町)
    • Year and Date
      2017-01-30
    • Related Report
      2016 Annual Research Report
  • [Presentation] ターゲット因子の解析を基盤とする生物活性物質が示す作用機構の解明2017

    • Author(s)
      坂本 聡、山口 雄輝、半田 宏
    • Organizer
      新学術領域研究「転写サイクル」冬の若手ワークショップ2017
    • Place of Presentation
      一宮シーサイドオーツカ(千葉県一宮町)
    • Year and Date
      2017-01-30
    • Related Report
      2016 Annual Research Report
  • [Presentation] DNA損傷時に誘導される転写制御の生理的意義とTLPの役割2017

    • Author(s)
      鈴木 秀文、前田 亮、木村 宏、浦 聖恵、山口 雄輝、田村 隆明
    • Organizer
      新学術領域研究「転写サイクル」冬の若手ワークショップ2017
    • Place of Presentation
      一宮シーサイドオーツカ(千葉県一宮町)
    • Year and Date
      2017-01-30
    • Related Report
      2016 Annual Research Report
  • [Presentation] 多発性骨髄腫における Pomalidomide 標的因子の網羅的探索2017

    • Author(s)
      舘野 峻平 、飯田 緑 、藤井 聡 、佐倉 絵里、山口 雄輝
    • Organizer
      新学術領域研究「転写サイクル」冬の若手ワークショップ2017
    • Place of Presentation
      一宮シーサイドオーツカ(千葉県一宮町)
    • Year and Date
      2017-01-30
    • Related Report
      2016 Annual Research Report
  • [Presentation] ウェットとドライの真の融合を目指して2017

    • Author(s)
      藤井 聡
    • Organizer
      冬の若手ワークショップ2017
    • Place of Presentation
      一宮シーサイドオーツカ(千葉県長生郡)
    • Year and Date
      2017-01-30
    • Related Report
      2016 Annual Research Report
  • [Presentation] 転写因子とヒストン修飾の関連性を提示するためのデータベース構築2017

    • Author(s)
      飯田 緑、藤井 聡
    • Organizer
      冬の若手ワークショップ2017
    • Place of Presentation
      一宮シーサイドオーツカ(千葉県長生郡)
    • Year and Date
      2017-01-30
    • Related Report
      2016 Annual Research Report
  • [Presentation] Multi-modal Dynamic Cross Correlation (mDCC) 法の開発と転写因子- DNA 複合体におけ る動的相関ネットワークの解析2017

    • Author(s)
      笠原 浩太
    • Organizer
      名古屋大学 IGER セミナー
    • Place of Presentation
      名古屋大学(愛知県名古屋市)
    • Related Report
      2016 Annual Research Report
  • [Presentation] 天然変性領域による転写制御の分子機構2017

    • Author(s)
      笠原 浩太
    • Organizer
      第5回 関西4私大 生命科学シンポジウム
    • Place of Presentation
      関西学院会館光の間(兵庫県西宮市)
    • Related Report
      2016 Annual Research Report
  • [Presentation] 1分子イメージングとFRAPによるINO80クロマチン再構成複合体の核内動態解析2016

    • Author(s)
      伊藤由馬, 原田昌彦, 木村宏, 十川久美子, 徳永万喜洋
    • Organizer
      第8回「光塾」
    • Place of Presentation
      東京工業大学すずかけ台キャンパス(神奈川県横浜市)
    • Year and Date
      2016-12-17
    • Related Report
      2016 Annual Research Report
  • [Presentation] How Pol II termination and 3' processing sites are precisely determined in higher eukaryotes.高等真核生物においてPol IIの転写終結と3'プロセシングの部位はいかにして正確に決定されるのか2016

    • Author(s)
      Ari Zukeran, Junichi Yamamoto, and Yuki Yamaguchi
    • Organizer
      第39回日本分子生物学会年会
    • Place of Presentation
      パシフィコ横浜(神奈川県横浜市)
    • Year and Date
      2016-11-30
    • Related Report
      2016 Annual Research Report
    • Invited
  • [Presentation] NELFを中心としたポリ(A)付加部位選択のメカニズム2016

    • Author(s)
      瑞慶覧 安里、山本 淳一、山口 雄輝
    • Organizer
      第39回日本分子生物学会年会
    • Place of Presentation
      パシフィコ横浜(神奈川県横浜市)
    • Year and Date
      2016-11-30
    • Related Report
      2016 Annual Research Report
  • [Presentation] パートナー因子によるEts1のコンフォーメーション分布の変化と活性制御機構の解析2016

    • Author(s)
      内山晃子,椎名政昭,浜田恵輔,馬場しほ,岡田千佳子,鈴木香絵,佐藤 光,緒方一博
    • Organizer
      第39回日本分子生物学会年会
    • Place of Presentation
      パシフィコ横浜 (神奈川県横浜市)
    • Year and Date
      2016-11-30
    • Related Report
      2016 Annual Research Report
  • [Presentation] 転写因子Ets1の天然変性領域のリン酸化によるDNA結合制御機構の速度論的解析2016

    • Author(s)
      椎名政昭,笠原浩太,肥後順一,馬場しほ,内山晃子,岡田千佳子,浜田恵輔,佐藤 光,中村春木,緒方一博
    • Organizer
      第39回日本分子生物学会年会
    • Place of Presentation
      パシフィコ横浜 (神奈川県横浜市)
    • Year and Date
      2016-11-30
    • Related Report
      2016 Annual Research Report
  • [Presentation] Single-molecule imaging of the INO80 chromatin remodeling complex in the living cell nucleus2016

    • Author(s)
      伊藤 由馬, 原田 昌彦, 十川久美子, 徳永万喜洋
    • Organizer
      第54回日本生物物理学会年会
    • Place of Presentation
      つくば国際会議場( 茨城県つくば市)
    • Year and Date
      2016-11-25
    • Related Report
      2016 Annual Research Report
  • [Presentation] CLIP-170 phosphorylation mediates repositioning of microtubule-organizing center during T cell activation2016

    • Author(s)
      林 偉銘, 伊藤 由馬, 徳永万喜洋, 十川久美子
    • Organizer
      第54回日本生物物理学会年会
    • Place of Presentation
      つくば国際会議場( 茨城県つくば市)
    • Year and Date
      2016-11-25
    • Related Report
      2016 Annual Research Report
  • [Presentation] Single molecule imaging and quantitative analysis of nucleolar-localized protein dynamics2016

    • Author(s)
      松本 大輝, 伊藤 由馬, 斉藤 典子,徳永万喜洋, 十川久美子
    • Organizer
      第54回日本生物物理学会年会
    • Place of Presentation
      つくば国際会議場( 茨城県つくば市)
    • Year and Date
      2016-11-25
    • Related Report
      2016 Annual Research Report
  • [Presentation] Super-resolution analysis of microtubule dynamics on T cell activation2016

    • Author(s)
      史 恒宇, 伊藤 由馬, 林 偉銘, 十川久美子, 徳永万喜洋
    • Organizer
      第54回日本生物物理学会年会
    • Place of Presentation
      つくば国際会議場( 茨城県つくば市)
    • Year and Date
      2016-11-25
    • Related Report
      2016 Annual Research Report
  • [Presentation] Fluorescence recovery after photobleaching(FRAP) analysis of INO80 chromatin remodeling complex2016

    • Author(s)
      磯垣 翼, 伊藤 由馬, 市川 翔太, 木村 宏, 原田 昌彦, 十川久美子, 徳永万喜洋
    • Organizer
      第54回日本生物物理学会年会
    • Place of Presentation
      つくば国際会議場( 茨城県つくば市)
    • Year and Date
      2016-11-25
    • Related Report
      2016 Annual Research Report
  • [Presentation] PDLIM2-interacting protein MKRN2 functions as a novel E3 ligase for p65 subunit of NF-κB2016

    • Author(s)
      申 纂暎, 伊藤 由馬, 徳永万喜洋, 田中 貴志, 十川久美子
    • Organizer
      第54回日本生物物理学会年会
    • Place of Presentation
      つくば国際会議場( 茨城県つくば市)
    • Year and Date
      2016-11-25
    • Related Report
      2016 Annual Research Report
  • [Presentation] Live cell imaging and quantitative analysis of anti-inflammatory protein PDLIM2 activation upon LPS stimulation2016

    • Author(s)
      市川 翔太, 伊藤 由馬, 田中 貴志, 徳永万喜洋, 十川久美子
    • Organizer
      第54回日本生物物理学会年会
    • Place of Presentation
      つくば国際会議場( 茨城県つくば市)
    • Year and Date
      2016-11-25
    • Related Report
      2016 Annual Research Report
  • [Presentation] Quantitative image analysis of dynamics of promoter-proximal pausing related proteins2016

    • Author(s)
      國見 慎之介, 伊藤 由馬, 山口 雄輝, 十川久美子, 徳永万喜洋
    • Organizer
      第54回日本生物物理学会年会
    • Place of Presentation
      つくば国際会議場( 茨城県つくば市)
    • Year and Date
      2016-11-25
    • Related Report
      2016 Annual Research Report
  • [Presentation] Flexible docking between cyclin-dependent kinase 2 and its inhibitor using multicanonical MD2016

    • Author(s)
      Gert-Jan Bekker, Narutoshi Kamiya, Mitsugu Araki, Yasushi Okuno, Haruki Nakamura
    • Organizer
      第54回日本生物物理学会年会
    • Place of Presentation
      つくば国際会議場(茨城県つくば市)
    • Year and Date
      2016-11-25
    • Related Report
      2016 Annual Research Report
  • [Presentation] 分子シミュレーションにおける静電相互作用計算法:零多重極子法の理論と実際2016

    • Author(s)
      福田 育夫, Wang Han, 神谷 成敏, 笠原 浩太, 寺田 透, 櫻庭 俊, 中村 春木
    • Organizer
      第54回日本生物物理学会年会
    • Place of Presentation
      つくば国際会議場(茨城県つくば市)
    • Year and Date
      2016-11-25
    • Related Report
      2016 Annual Research Report
  • [Presentation] Oct4の2つのDNA結合サブドメインを結ぶ柔軟なlinker領域の自由エネルギー地形2016

    • Author(s)
      速水 智教、高田 彰二、中村 春木、肥後 順一
    • Organizer
      第54回日本生物物理学会年会
    • Place of Presentation
      つくば国際会議場(茨城県つくば市)
    • Year and Date
      2016-11-25
    • Related Report
      2016 Annual Research Report
  • [Presentation] 巨大生体分子の長時間 MD シミュレーションの開発と生体分子の構造機能相関の解明2016

    • Author(s)
      鷹野 優、Neetha Mohan、草鹿 あゆみ、川端 猛、笠原 浩太、真下 忠彰、神谷 成敏、中村 春木
    • Organizer
      第8回「学際計算科学による新たな知の発展・統合・創出」 シンポジウム
    • Place of Presentation
      筑波大学計算科学研究センター(茨城県つくば市)
    • Year and Date
      2016-10-17
    • Related Report
      2016 Annual Research Report
  • [Presentation] 高等真核生物においてPOL Ⅱの転写終結と3'プロセシングの部位はいかにして正確に決定されるのか2016

    • Author(s)
      瑞慶覧 安里、長谷川 冴妃子、館野 峻平、山本 淳一、山口 雄輝
    • Organizer
      新学術領域研究「転写サイクル」班会議2016
    • Place of Presentation
      松島一の坊(宮城県宮城郡)
    • Year and Date
      2016-09-05
    • Related Report
      2016 Annual Research Report
  • [Presentation] TBP類似因子TLPによるDNA損傷応答時の転写抑制と細胞死誘導機構の解析2016

    • Author(s)
      鈴木 秀文、前田 亮、浦 聖恵、木村 宏、山口 雄輝、田村 隆明
    • Organizer
      新学術領域研究「転写サイクル」班会議2016
    • Place of Presentation
      松島一の坊(宮城県宮城郡)
    • Year and Date
      2016-09-05
    • Related Report
      2016 Annual Research Report
  • [Presentation] NELFを中心としたポリ(A)付加部位選択のメカニズム2016

    • Author(s)
      瑞慶覧 安里、館野 峻平、山本 淳一、山口 雄輝
    • Organizer
      新学術領域研究「転写サイクル」班会議2016
    • Place of Presentation
      松島一の坊(宮城県宮城郡)
    • Year and Date
      2016-09-05
    • Related Report
      2016 Annual Research Report
  • [Presentation] 公共ChIP-Seqデータの統合解析による転写制御の解析2016

    • Author(s)
      藤井 聡
    • Organizer
      転写サイクル合同班会議2016
    • Place of Presentation
      松島一の坊(宮城県宮城郡)
    • Year and Date
      2016-09-05
    • Related Report
      2016 Annual Research Report
  • [Presentation] 転写産物とPolIIエンリッチメントプロファイリングによるDecapping exoribonuclease (Dom3z) の機能解析2016

    • Author(s)
      飯田 緑、磯部 智康、山口 雄輝、藤井 聡
    • Organizer
      転写サイクル合同班会議2016
    • Place of Presentation
      松島一の坊(宮城県宮城郡)
    • Year and Date
      2016-09-05
    • Related Report
      2016 Annual Research Report
  • [Presentation] 計算・情報科学による 転写サイクルにおける情報変換機構の解明2016

    • Author(s)
      笠原 浩太、Neetha Mohan、中村 春木
    • Organizer
      転写サイクル合同班会議2016
    • Place of Presentation
      松島一の坊(宮城県宮城郡)
    • Year and Date
      2016-09-05
    • Related Report
      2016 Annual Research Report
  • [Presentation] Molecular behavior of a higher-order complex of multiple transcription factors on enhancer site upon phosphorylation2016

    • Author(s)
      Ogata K, Shiina M, Kasahara K, Higo J, Hamada K, Nakamura H
    • Organizer
      6th International Conference on Structural Biology (Structural Biology 2016)
    • Place of Presentation
      Hilton New Orleans Airport Hotel (米国ルイジアナ州)
    • Year and Date
      2016-08-22
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] DELLA-GAF1/IDD2 complex regulates gibberellin homeostasis and signaling2016

    • Author(s)
      Fukazawa, J., Ito, T., Takahashi, Y.
    • Organizer
      22nd International Plant Growth Substances Association Conference
    • Place of Presentation
      トロント(カナダ)
    • Year and Date
      2016-06-21
    • Related Report
      2016 Annual Research Report 2015 Annual Research Report
    • Int'l Joint Research
  • [Presentation] CRBNに対するサリドマイド光学異性体の結合基盤解析2016

    • Author(s)
      坂本 聡、伊藤 拓水、森 智行、安藤 秀樹、山口 雄輝、箱嶋 敏雄、半田 宏
    • Organizer
      日本ケミカルバイオロジー学会第11回年会
    • Place of Presentation
      京都テルサ(京都府京都市)
    • Year and Date
      2016-06-15
    • Related Report
      2016 Annual Research Report
  • [Presentation] リガンド依存的ユビキチンリガーゼCRBNの制御機構2016

    • Author(s)
      伊藤 拓水、朝妻 知子、山本 淳一 安藤 秀樹、佐藤 智美、山口 雄輝、半田 宏
    • Organizer
      日本ケミカルバイオロジー学会第11回年会
    • Place of Presentation
      京都テルサ(京都府京都市)
    • Year and Date
      2016-06-15
    • Related Report
      2016 Annual Research Report
  • [Presentation] p53 C末端ドメインのアセチル化およびヒスチジンの荷電状態の変化がその立体構造集団に及ぼす影響2016

    • Author(s)
      飯田 慎仁, 牟田 寛弥, 後藤 祐児, 北條 裕信, 中村 春木, 肥後 順一
    • Organizer
      第16回日本蛋白質科学会年会
    • Place of Presentation
      福岡国際会議場(福岡県福岡市)
    • Year and Date
      2016-06-07
    • Related Report
      2016 Annual Research Report
  • [Presentation] 天然変性領域の過渡的な相互作用による転写制御の分子機構2016

    • Author(s)
      笠原 浩太、椎名 政昭、肥後 順一、緒方 一博、中村 春木
    • Organizer
      第16回日本蛋白質科学会年会
    • Place of Presentation
      福岡国際会議場(福岡県福岡市)
    • Year and Date
      2016-06-07
    • Related Report
      2016 Annual Research Report
  • [Presentation] Insights Derived from Molecular Dynamics Simulations into the Subunit Assembly and Clamp Motions of Thermococcus kodakarensis RNA Polymerase2016

    • Author(s)
      Neetha Mohan, Kota Kasahara, Akira Hirata, Haruki Nakamura
    • Organizer
      第16回日本蛋白質科学会年会
    • Place of Presentation
      福岡国際会議場(福岡県福岡市)
    • Year and Date
      2016-06-07
    • Related Report
      2016 Annual Research Report
  • [Presentation] An efficient new methodology for path elucidation and binding free energy calculation2016

    • Author(s)
      Gert-Jan Bekker, Narutoshi Kamiya, Haruki Nakamura
    • Organizer
      第16回日本蛋白質科学会年会
    • Place of Presentation
      福岡国際会議場(福岡県福岡市)
    • Year and Date
      2016-06-07
    • Related Report
      2016 Annual Research Report
  • [Presentation] Molecular mechanism for modulation of a multiple transcription factor complex formed on enhancer site up on phosphorylation2016

    • Author(s)
      Ogata K, Shiina M, Kasahara K, Higo J, Hamada K, Nakamura H
    • Organizer
      5th International Conference and Exhibition on Metabolomics
    • Place of Presentation
      ハイアットリージェンシー大阪(大阪府大阪市)
    • Year and Date
      2016-05-16
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] GAF1複合体によるGA生合成酵素遺伝子の転写抑制機構の解析(優秀発表賞受賞)2016

    • Author(s)
      勝部隆義, 伊藤岳, 深澤壽太郎, 高橋陽介
    • Organizer
      第73回 中国四国植物学会
    • Place of Presentation
      米子コンベンションセンター(島根県)
    • Year and Date
      2016-05-15
    • Related Report
      2016 Annual Research Report
  • [Presentation] ジベレリンとオーキシンによる茎部の伸長制御機構の解析(優秀発表賞受賞)2016

    • Author(s)
      伊東裕太, 伊藤岳, 高橋陽介
    • Organizer
      第73回 中国四国植物学会
    • Place of Presentation
      米子コンベンションセンター(島根県)
    • Year and Date
      2016-05-15
    • Related Report
      2016 Annual Research Report
  • [Presentation] DELLA-GAF1複合体によるジベレリン信号伝達の制御機構2016

    • Author(s)
      深澤壽太郎、高橋竜平、藤井麻弥、高橋陽介
    • Organizer
      第73回 中国四国植物学会
    • Place of Presentation
      米子コンベンションセンター(島根県)
    • Year and Date
      2016-05-15
    • Related Report
      2016 Annual Research Report
  • [Presentation] DELLA-GAF1複合体によるジベレリン信号伝達の制御機構2016

    • Author(s)
      深澤 壽太郎、高橋 竜平、藤井 麻弥、高橋 陽介
    • Organizer
      第73回中国四国植物学会
    • Place of Presentation
      米子コンベンションセンター(鳥取県米子市)
    • Year and Date
      2016-05-15
    • Related Report
      2015 Annual Research Report
  • [Presentation] ジベレリンとオーキシンによる茎部の伸長制御機構の解析2016

    • Author(s)
      伊東 裕太, 伊藤 岳, 高橋 陽介
    • Organizer
      第73回中国四国植物学会
    • Place of Presentation
      米子コンベンションセンター(鳥取県米子市)
    • Year and Date
      2016-05-14
    • Related Report
      2015 Annual Research Report
  • [Presentation] GAF1複合体によるGA生合成酵素遺伝子の転写抑制機構の解析2016

    • Author(s)
      勝部 隆義, 伊藤 岳, 深澤 壽太郎, 高橋 陽介
    • Organizer
      第73回中国四国植物学会
    • Place of Presentation
      米子コンベンションセンター(鳥取県米子市)
    • Year and Date
      2016-05-14
    • Related Report
      2015 Annual Research Report
  • [Presentation] カルシウム依存性タンパク質リン酸化酵素NtCDPK1の自己リン酸化による機能制御の解析2016

    • Author(s)
      伊藤 岳, 石田 さらみ, 高橋 陽介
    • Organizer
      第57回日本植物生理学会
    • Place of Presentation
      岩手大学(岩手県岩手市)
    • Year and Date
      2016-03-19
    • Related Report
      2015 Annual Research Report
  • [Presentation] ヒストンH2Aのリン酸化と癌化2016

    • Author(s)
      伊藤 敬
    • Organizer
      生物多様性コロキウム
    • Place of Presentation
      京都大学(京都府京都市)
    • Year and Date
      2016-03-14
    • Related Report
      2015 Annual Research Report
  • [Presentation] BigData to Knowledge to Wisdom2016

    • Author(s)
      Haruki Nakamura
    • Organizer
      Data Sharing Symposium
    • Place of Presentation
      一橋大学一橋講堂(東京都千代田区)
    • Year and Date
      2016-02-29
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] ヒストン翻訳後修飾と癌化2016

    • Author(s)
      伊藤 敬
    • Organizer
      Science Medical Frontier Forum
    • Place of Presentation
      御茶ノ水ソラシティカンファレンスセンター(東京都千代田区)
    • Year and Date
      2016-02-08
    • Related Report
      2015 Annual Research Report
  • [Presentation] 多発性骨髄腫におけるPomalidomide標的因子の網羅的探索2016

    • Author(s)
      舘野 峻平、飯田 緑、藤井 聡、山口 雄輝
    • Organizer
      冬の若手ワークショップ2016
    • Place of Presentation
      ホテル清渓(山梨県南都留郡)
    • Year and Date
      2016-02-05
    • Related Report
      2015 Annual Research Report
  • [Presentation] 新規抗がん剤の作用機構の解明2016

    • Author(s)
      佐倉 絵里、舘野 峻平、山口 雄輝
    • Organizer
      冬の若手ワークショップ2016
    • Place of Presentation
      ホテル清渓(山梨県南都留郡)
    • Year and Date
      2016-02-05
    • Related Report
      2015 Annual Research Report
  • [Presentation] PolⅡ複合体をモデルとしたタンパク質間相互作用の実験系の評価2016

    • Author(s)
      新垣 貴之、徳山 遥香、山口 雄輝
    • Organizer
      冬の若手ワークショップ2016
    • Place of Presentation
      ホテル清渓(山梨県南都留郡)
    • Year and Date
      2016-02-05
    • Related Report
      2015 Annual Research Report
  • [Presentation] NELFを中心としたRNAの品質管理のメカニズム2016

    • Author(s)
      瑞慶覧 安里、山本 淳一、磯部 智康、山口 雄輝
    • Organizer
      冬の若手ワークショップ2016
    • Place of Presentation
      ホテル清渓(山梨県南都留郡)
    • Year and Date
      2016-02-05
    • Related Report
      2015 Annual Research Report
  • [Presentation] サリドマイド標的タンパク質CRBNの相互作用因子の探索2016

    • Author(s)
      徳山 遥香、新垣 貴之、山口雄輝
    • Organizer
      冬の若手ワークショップ2016
    • Place of Presentation
      ホテル清渓(山梨県南都留郡)
    • Year and Date
      2016-02-05
    • Related Report
      2015 Annual Research Report
  • [Presentation] マウスES細胞における2細胞期特異的な遺伝子の発現制御メカニズムの解析2016

    • Author(s)
      鈴木 翔子、柴田 紘孝、山口 雄輝
    • Organizer
      冬の若手ワークショップ2016
    • Place of Presentation
      ホテル清渓(山梨県南都留郡)
    • Year and Date
      2016-02-05
    • Related Report
      2015 Annual Research Report
  • [Presentation] サリドマイドの多様な薬理作用の分子メカニズム2016

    • Author(s)
      山口 雄輝、伊藤 巧水、山本 淳一、半田 宏
    • Organizer
      冬の若手ワークショップ2016
    • Place of Presentation
      ホテル清渓(山梨県南都留郡)
    • Year and Date
      2016-02-05
    • Related Report
      2015 Annual Research Report
  • [Presentation] snRNA3'末端プロセシング因子インテグレーターの構造・機能解析2016

    • Author(s)
      外山 黛、荻原 裕里、Thiengtrong, Benjarat、山口 雄輝
    • Organizer
      冬の若手ワークショップ2016
    • Place of Presentation
      ホテル清渓(山梨県南都留郡)
    • Year and Date
      2016-02-05
    • Related Report
      2015 Annual Research Report
  • [Presentation] Decapping exoribonuclease(DOX:Dom3z)の転写制御における機能解析2016

    • Author(s)
      飯田緑、磯部智康、山口雄輝、藤井聡
    • Organizer
      冬の若手ワークショップ2015
    • Place of Presentation
      ホテル清渓(山梨県南都留郡)
    • Year and Date
      2016-02-04
    • Related Report
      2015 Annual Research Report
  • [Presentation] Computational approaches to analyze and predict protein-protein interactions2016

    • Author(s)
      Haruki Nakamura
    • Organizer
      IPR International Workshop
    • Place of Presentation
      大阪大学蛋白質研究所 (大阪府吹田市)
    • Year and Date
      2016-02-02
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] 細胞核内アクチンフィラメントのゲノム機能への関与2016

    • Author(s)
      山崎祥他,山本浩二,十川久美子,徳永万喜洋,原田昌彦
    • Organizer
      第33回染色体ワークショップ・第14回核ダイナミクス研究会
    • Place of Presentation
      一の坊(宮城県宮城郡)
    • Year and Date
      2016-01-12
    • Related Report
      2015 Annual Research Report
  • [Presentation] 細胞分化における核内アクチンの機能解析2016

    • Author(s)
      山本浩二,山崎祥他,十川久美子,徳永万喜洋,原田昌彦
    • Organizer
      第33回染色体ワークショップ・第14回核ダイナミクス研究会
    • Place of Presentation
      一の坊(宮城県宮城郡)
    • Year and Date
      2016-01-12
    • Related Report
      2015 Annual Research Report
  • [Presentation] Somatic mutation in Sturge Weber syndrome2016

    • Author(s)
      Naomichi Matsumoto
    • Organizer
      The 11th Asisan & Oceanian Epilepsy Congress(AOEC)
    • Place of Presentation
      Hong Kong Convention & Exhibition Centre(香港)
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Rare variants in human diseases2016

    • Author(s)
      Naomichi Matsumoto
    • Organizer
      International Symposium on Genomic Medicine 2016
    • Place of Presentation
      Samsung Medical Center(韓国ソウル市)
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Mendelian Exome in Japan2016

    • Author(s)
      Naomichi Matsumoto
    • Organizer
      LMCE2016, Symposium 13
    • Place of Presentation
      The-K Hotel(韓国ソウル市)
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Rare variants in human diseases2016

    • Author(s)
      Naomichi Matsumoto
    • Organizer
      The 2016 Annual Meeting of the Chinese Society of Medical Genetics (CSMG)
    • Place of Presentation
      中国杭州市
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] New Methods for Structure Guided Drug Development2016

    • Author(s)
      Haruki Nakamura
    • Organizer
      JCUP VII
    • Place of Presentation
      大手町サンスカイルーム朝日生命大手町ビル(東京都千代田区)
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Computational Approaches to Coupled Folding and Binding in Protein-Protein Interactions2016

    • Author(s)
      Haruki Nakamura
    • Organizer
      21st Biophysics Conference
    • Place of Presentation
      Hsinchu (台湾)
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Computational analysis on electrostatic properties of protein and Protein-Protein Interactions2016

    • Author(s)
      Haruki Nakamura
    • Organizer
      Asia Pacific Protein Association (APPA), IPR International Seminar
    • Place of Presentation
      大阪大学蛋白質研究所(大阪府吹田市)
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] バイオインフォマティクスの世界へようこそ2016

    • Author(s)
      飯田 緑
    • Organizer
      第3回LaMer 特別講演会
    • Place of Presentation
      愛媛大学(愛媛県松山市)
    • Related Report
      2016 Annual Research Report
  • [Presentation] Computational Approaches to Coupled Folding and Binding in Protein-Protein Interactions2016

    • Author(s)
      Haruki Nakamura
    • Organizer
      The 11th International Symposium of the Protein Society of Thailand
    • Place of Presentation
      Bangkok (タイ)
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Computational Approaches to Protein Interactions2016

    • Author(s)
      Haruki Nakamura
    • Organizer
      Japan-Slovenia JSPS Bilateral scientific exchange
    • Place of Presentation
      Koper(スロベニア)
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] 1分子顕微鏡で観る免疫細胞活性化の初期過程2015

    • Author(s)
      十川久美子
    • Organizer
      宇都宮大学 オプト-バイオシンポジウム
    • Place of Presentation
      宇都宮大学(栃木県宇都宮市)
    • Year and Date
      2015-12-21
    • Related Report
      2015 Annual Research Report
    • Invited
  • [Presentation] 最先端テクノロジーによる疾患ゲノム解析2015

    • Author(s)
      松本 直通
    • Organizer
      第1回日本産婦人科遺伝診療学会学術講演会・教育講演
    • Place of Presentation
      長崎ブリックホール(長崎県長崎市)
    • Year and Date
      2015-12-18
    • Related Report
      2015 Annual Research Report
    • Invited
  • [Presentation] Elucidation of the molecular mechanisms of action of bioactive natural products using high performance affinity beads2015

    • Author(s)
      Satoshi Sakamoto, Yuki Yamaguchi, Takumi Ito, Hiroshi Handa
    • Organizer
      PACIFCHEM2015
    • Place of Presentation
      ホノルル(アメリカ)
    • Year and Date
      2015-12-17
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Biochemical analyses of CRBN, the target protein for immunomodulatory drugs (IMiDs)2015

    • Author(s)
      Satoshi Sakamoto, Takumi Ito, Yuki Yamaguchi, Hideki Ando, Hiroshi Handa
    • Organizer
      PACIFCHEM2015
    • Place of Presentation
      ホノルル(アメリカ)
    • Year and Date
      2015-12-16
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research
  • [Presentation] ヒト疾患とrare variants2015

    • Author(s)
      松本 直通
    • Organizer
      第23回食細胞機能異常症研究会
    • Place of Presentation
      東京慈恵医科大学(東京都港区)
    • Year and Date
      2015-12-12
    • Related Report
      2015 Annual Research Report
    • Invited
  • [Presentation] Computational approach to find a specific interaction among many IDR relating fuzzy complexes2015

    • Author(s)
      Haruki Nakamura
    • Organizer
      International Symposium on Structure and Folding of Disease Related Proteins
    • Place of Presentation
      ソウル(韓国)
    • Year and Date
      2015-12-04
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] 多発性骨髄腫に対するポマリドマイドの標的因子の網羅的探索2015

    • Author(s)
      館野 俊平、飯田 緑、藤井 聡、山口 雄輝
    • Organizer
      第38回日本分子生物学会年会
    • Place of Presentation
      神戸ポートアイランド(兵庫県神戸市)
    • Year and Date
      2015-12-03
    • Related Report
      2015 Annual Research Report
  • [Presentation] EPR1の新規転写抑制モチーフの機能解析2015

    • Author(s)
      伊藤 岳, 岡村 僚太, 佐久間 哲史, 山本 卓, 高橋 陽介
    • Organizer
      第38回日本分子生物学会
    • Place of Presentation
      神戸ポートアイランド(兵庫県神戸市)
    • Year and Date
      2015-12-03
    • Related Report
      2015 Annual Research Report
  • [Presentation] ATP依存的なクロマチンリモデリング因子でCBPによるヒストンアセチル化を刺激し転写を亢進する2015

    • Author(s)
      土井口 真康 、中川 武弥 、伊藤 敬
    • Organizer
      第38回日本分子生物学会年会
    • Place of Presentation
      神戸ポートピアホテル(兵庫県神戸市)
    • Year and Date
      2015-12-01
    • Related Report
      2015 Annual Research Report
  • [Presentation] Dzip3はマウス胚性幹細胞において染色体の高次構造を調整することによって発生に関する遺伝子を制御する2015

    • Author(s)
      井上 大嗣、里 龍晴、相原 仁、水崎 博文、土井口 真康、東 美樹、宮西 隆幸、奥田 晶彦、中川武弥、伊藤 敬
    • Organizer
      第38回日本分子生物学会年会
    • Place of Presentation
      ポートピアホテル(兵庫県神戸市)
    • Year and Date
      2015-12-01
    • Related Report
      2015 Annual Research Report
  • [Presentation] Ets1とRunx1のエンハンサー上での立体的な位置関係と協調性2015

    • Author(s)
      内山 晃子,椎名 政昭,浜田 恵輔,豊後 泰子,嶋村 麻利子,緒方 一博
    • Organizer
      BMB2015(第38回日本分子生物学会年会、第88回日本生化学会大会 合同大会)
    • Place of Presentation
      神戸ポートアイランド(兵庫県神戸市)
    • Year and Date
      2015-12-01
    • Related Report
      2015 Annual Research Report
  • [Presentation] Kinetic characterization of a DNA binding activity of the transcription factor Ets1 and its regulation by phosphorylation in an intrinsically disordered region2015

    • Author(s)
      Shiina M, Kasahara K, Higo J, Baba S, Hamada K, Uchiyama A, Suzuki K, Sato K, Nakamura H, Ogata K
    • Organizer
      BMB2015(第38回日本分子生物学会年会、第88回日本生化学会大会 合同大会)
    • Place of Presentation
      神戸ポートアイランド(兵庫県神戸市)
    • Year and Date
      2015-12-01
    • Related Report
      2015 Annual Research Report
  • [Presentation] 分子構造に基づく転写因子Nuclear factor (erythroid-derived2)-like2(Nrf2)の抗酸化剤応答配列認識機構の解析2015

    • Author(s)
      鈴木 香絵,椎名 政昭,浜田 恵輔,石川 涼平,金井 達哉,豊後 泰子,岡田 千佳子,馬場 しほ,鈴木 隆史,太田 力,山本 雅之,緒方 一博
    • Organizer
      BMB2015(第38回日本分子生物学会年会、第88回日本生化学会大会 合同大会)
    • Place of Presentation
      神戸ポートアイランド(兵庫県神戸市)
    • Year and Date
      2015-12-01
    • Related Report
      2015 Annual Research Report
  • [Presentation] Somatic mutations in the MTOR gene cause focal cortical dysplasia type IIb2015

    • Author(s)
      Naomichi Matsumoto
    • Organizer
      Biochemistry and Molecular Biology (BMB) 2015
    • Place of Presentation
      神戸ポートピアホテル(兵庫県神戸市)
    • Year and Date
      2015-12-01
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] 遺伝子解析におけるドロップレットディジタルPCRの活用2015

    • Author(s)
      松本直通
    • Organizer
      第38回日本分子生物学会年会(第88回日本生化学会大会)BMB2015, ランチョンセミナー
    • Place of Presentation
      神戸ポートピアホテル(兵庫県神戸市)
    • Year and Date
      2015-12-01
    • Related Report
      2015 Annual Research Report
    • Invited
  • [Presentation] A specific interaction among many fuzzy complexes regulated by phosphorylation: Molecular simulation approach2015

    • Author(s)
      Haruki Nakamura
    • Organizer
      RSC/IPR Joint Symposium “Protein Structure and Function”
    • Place of Presentation
      キャンベラ(オーストラリア)
    • Year and Date
      2015-11-14
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Pol IIの転写伸長と運命決定制御のメカニズム2015

    • Author(s)
      山口 雄輝
    • Organizer
      第2回北陸エピジェネティクス研究会
    • Place of Presentation
      富山大学(富山県富山市)
    • Year and Date
      2015-11-10
    • Related Report
      2015 Annual Research Report
    • Invited
  • [Presentation] Rare variants in human diseases2015

    • Author(s)
      Naomichi Matsumoto
    • Organizer
      University of Split Lecture
    • Place of Presentation
      スプリット(クロアチア)
    • Year and Date
      2015-11-09
    • Related Report
      2015 Annual Research Report
    • Invited
  • [Presentation] Next Generation Sequencing Dissecting Human “Genetic” Diseases2015

    • Author(s)
      Naomichi Matsumoto
    • Organizer
      The VI Croatian Congress of Human Genetics
    • Place of Presentation
      スプリット(クロアチア)
    • Year and Date
      2015-11-06
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] ジベレリン信号伝達におけるDELLA-GAF1複合体の標的遺伝子の探索2015

    • Author(s)
      深澤 壽太郎、高橋 竜平、藤井 麻弥、三島 由佳、高橋 陽介
    • Organizer
      第50回植物化学調節学会大会
    • Place of Presentation
      東京大学(東京都文京区)
    • Year and Date
      2015-10-25
    • Related Report
      2015 Annual Research Report
  • [Presentation] 低頻度体細胞モザイク変異が惹起するヒト疾患2015

    • Author(s)
      松本 直通
    • Organizer
      日本人類遺伝学会第60回大会
    • Place of Presentation
      京王プラザホテル(東京都新宿区)
    • Year and Date
      2015-10-16
    • Related Report
      2015 Annual Research Report
  • [Presentation] クロマチン動態制御におけるアクチン関連タンパク質Arp4の核内ダイナミクス2015

    • Author(s)
      伊藤由馬,木村宏,原田昌彦,十川久美子,徳永万喜洋
    • Organizer
      第53回日本生物物理学会年会
    • Place of Presentation
      金沢大学(石川県金沢市)
    • Year and Date
      2015-09-13
    • Related Report
      2015 Annual Research Report
  • [Presentation] Yeast two hybridおよび定量イメージング解析によるPDLIM2相互作用タンパク質の同定2015

    • Author(s)
      申纂暎,伊藤由馬,十川久美子,田中貴志,徳永万喜洋
    • Organizer
      第53回日本生物物理学会年会
    • Place of Presentation
      金沢大学(石川県金沢市)
    • Year and Date
      2015-09-13
    • Related Report
      2015 Annual Research Report
  • [Presentation] リポ多糖刺激における炎症抑制タンパク質PDLIM2活性化のイメージング定量解析2015

    • Author(s)
      市川翔太,伊藤由馬,田中貴志,徳永万喜洋,十川久美子
    • Organizer
      第53回日本生物物理学会年会
    • Place of Presentation
      金沢大学(石川県金沢市)
    • Year and Date
      2015-09-13
    • Related Report
      2015 Annual Research Report
  • [Presentation] CLIP170 phosphorylation mediates repositioning of microtubule-organizing center during T cell activation2015

    • Author(s)
      林偉銘,伊藤由馬,徳永万喜洋,十川久美子
    • Organizer
      第53回日本生物物理学会年会
    • Place of Presentation
      金沢大学(石川県金沢市)
    • Year and Date
      2015-09-13
    • Related Report
      2015 Annual Research Report
  • [Presentation] 蛍光褪色回復法によるINO80クロマチンリモデリング複合体の核内動態解析2015

    • Author(s)
      伊藤由馬,磯垣翼,木村宏,原田昌彦,十川久美子,徳永万喜洋
    • Organizer
      第53回日本生物物理学会年会
    • Place of Presentation
      金沢大学(石川県金沢市)
    • Year and Date
      2015-09-13
    • Related Report
      2015 Annual Research Report
  • [Presentation] 1分子イメージングによる転写伸長因子NELFとDSIFのダイナミクス定量解析2015

    • Author(s)
      池田大地,伊藤由馬,徳永万喜洋,十川久美子
    • Organizer
      第53回日本生物物理学会年会
    • Place of Presentation
      金沢大学(石川県金沢市)
    • Year and Date
      2015-09-13
    • Related Report
      2015 Annual Research Report
  • [Presentation] 転写因子Ets1天然変性領域のリン酸化によるDNA認識阻害メカニズムの検討2015

    • Author(s)
      笠原浩太、肥後順一、椎名政昭、緒方一博、中村春木
    • Organizer
      第53回日本生物物理学会年会
    • Place of Presentation
      金沢大学角間キャンパス(石川県金沢市)
    • Year and Date
      2015-09-13
    • Related Report
      2015 Annual Research Report
  • [Presentation] EMDBとPDBデータの形状類似検索:Omokage検索2015

    • Author(s)
      鈴木博文, 川端猛, 中村春木
    • Organizer
      第53回日本生物物理学会年会
    • Place of Presentation
      金沢大学角間キャンパス(石川県金沢市)
    • Year and Date
      2015-09-13
    • Related Report
      2015 Annual Research Report
  • [Presentation] ヘムの構造歪みが酸化還元電位に与える影響の計算科学的研究2015

    • Author(s)
      今田康博, 中村春木, 鷹野優
    • Organizer
      第53回日本生物物理学会年会
    • Place of Presentation
      金沢大学角間キャンパス(石川県金沢市)
    • Year and Date
      2015-09-13
    • Related Report
      2015 Annual Research Report
  • [Presentation] 抗体CDR-H3ループ領域の立体構造予測2015

    • Author(s)
      西上博士, Gert-Jan Bekker, 神谷成敏, 肥後順一, 中村春木
    • Organizer
      第53回日本生物物理学会年会
    • Place of Presentation
      金沢大学角間キャンパス(石川県金沢市)
    • Year and Date
      2015-09-13
    • Related Report
      2015 Annual Research Report
  • [Presentation] 天然変性領域であるp53C末端ドメインの構造と物性にアセチル化が及ぼす影響2015

    • Author(s)
      飯田慎仁, 北條裕信, 中村春木, 肥後順一
    • Organizer
      第53回日本生物物理学会年会
    • Place of Presentation
      金沢大学角間キャンパス(石川県金沢市)
    • Year and Date
      2015-09-13
    • Related Report
      2015 Annual Research Report
  • [Presentation] On the convergence of binding free-energy landscape calculation by improved virtual-system coupled adaptive umbrella sampling2015

    • Author(s)
      Bhaskar Dasgupta, 肥後順一, 中村春木
    • Organizer
      第53回日本生物物理学会年会
    • Place of Presentation
      金沢大学角間キャンパス(石川県金沢市)
    • Year and Date
      2015-09-13
    • Related Report
      2015 Annual Research Report
  • [Presentation] A novel method to determine the optimal unbinding path between receptor and ligand using advanced molecular dynamics simulation2015

    • Author(s)
      Gert-Jan Bekker, 神谷成敏, 中村春木
    • Organizer
      第53回日本生物物理学会年会
    • Place of Presentation
      金沢大学角間キャンパス(石川県金沢市)
    • Year and Date
      2015-09-13
    • Related Report
      2015 Annual Research Report
  • [Presentation] 低解像度密度マップへの複数のサブユニットのあてはめ計算-実験情報による拘束の利用-2015

    • Author(s)
      川端猛, 鈴木博文, 中村春木
    • Organizer
      第53回日本生物物理学会年会
    • Place of Presentation
      金沢大学角間キャンパス(石川県金沢市)
    • Year and Date
      2015-09-13
    • Related Report
      2015 Annual Research Report
  • [Presentation] Molecular Tailoring Approach法による蛋白質二次構造内に働く相互作用の量子化学的研究2015

    • Author(s)
      草鹿あゆみ, 中村春木, 鷹野優
    • Organizer
      第53回日本生物物理学会年会
    • Place of Presentation
      金沢大学角間キャンパス(石川県金沢市)
    • Year and Date
      2015-09-13
    • Related Report
      2015 Annual Research Report
  • [Presentation] 分子シミュレーションにおける静電相互作用計算のための新規非エバルト法2015

    • Author(s)
      福田育夫, 神谷成敏, Han Wang, 笠原浩太、中村春木
    • Organizer
      第53回日本生物物理学会年会
    • Place of Presentation
      金沢大学角間キャンパス(石川県金沢市)
    • Year and Date
      2015-09-13
    • Related Report
      2015 Annual Research Report
  • [Presentation] Interaction of two subunits of D/L hetero dimer with catalytic subunits in archaeal RNA polymerase: Insights from MD simulations2015

    • Author(s)
      Neetha Mohan, 笠原浩太、平田章、中村春木
    • Organizer
      第53回日本生物物理学会年会
    • Place of Presentation
      金沢大学角間キャンパス(石川県金沢市)
    • Year and Date
      2015-09-13
    • Related Report
      2015 Annual Research Report
  • [Presentation] Regulatory Mechanisms for Pol II Termination Sites and 3' Processing Pathways in Higher Eukaryotes2015

    • Author(s)
      Yuki Yamaguchi and Junichi Yamamoto
    • Organizer
      MECHANISM OF EUKARYOTIC TRANSCRIPTION
    • Place of Presentation
      Cold Spring Harbor(アメリカ)
    • Year and Date
      2015-08-27
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 転写伸張因子DSIFのCTRを介した転写制御機構の解析2015

    • Author(s)
      磯部 智康、山口 雄輝
    • Organizer
      転写サイクル班会議2015
    • Place of Presentation
      ホテル暖香園(静岡県伊東市)ホテル暖香園
    • Year and Date
      2015-08-05
    • Related Report
      2015 Annual Research Report
  • [Presentation] NELFを中心としたmRNAの品質管理のメカニズム2015

    • Author(s)
      瑞慶覧 安里、山本 淳一、磯部 智康、山口 雄輝
    • Organizer
      転写サイクル班会議2015
    • Place of Presentation
      ホテル暖香園(静岡県伊東市)
    • Year and Date
      2015-08-05
    • Related Report
      2015 Annual Research Report
  • [Presentation] 転写伸長段階の制御メカニズム:新たな制御因子の探索2015

    • Author(s)
      山口 雄輝、磯部 智康、曹 青福、山本 淳一
    • Organizer
      転写サイクル班会議2015
    • Place of Presentation
      ホテル暖香園(静岡県伊東市)
    • Year and Date
      2015-08-04
    • Related Report
      2015 Annual Research Report
  • [Presentation] 分子シミュレーションから解き明かす転写因子Ets1のDNA結合調節機構2015

    • Author(s)
      笠原浩太、Neetha Mohan、肥後順一、福田育夫、中村春木
    • Organizer
      転写サイクル合同班会議2015
    • Place of Presentation
      ホテル暖香園(静岡県伊東市)
    • Year and Date
      2015-08-03
    • Related Report
      2015 Annual Research Report
  • [Presentation] 転写制御に関係するヒストン修飾パターンの解析2015

    • Author(s)
      藤井 聡、西山 晃、田村 智彦
    • Organizer
      転写サイクル合同班会議2015
    • Place of Presentation
      ホテル暖香園(静岡県伊東市)
    • Year and Date
      2015-08-03
    • Related Report
      2015 Annual Research Report
  • [Presentation] RNA polymerase IIのプロファイル解析2015

    • Author(s)
      飯田 緑、磯部 智康、山口 雄輝、藤井 聡
    • Organizer
      転写サイクル合同班会議2015
    • Place of Presentation
      ホテル暖香園(静岡県伊東市)
    • Year and Date
      2015-08-03
    • Related Report
      2015 Annual Research Report
  • [Presentation] 遺伝性疾患における話題提供2015

    • Author(s)
      松本 直通
    • Organizer
      第22回日本遺伝子診療学会大会・プレシジョン医療と診断情報の質保証
    • Place of Presentation
      かながわ労働プラザ(神奈川県横浜市)
    • Year and Date
      2015-07-19
    • Related Report
      2015 Annual Research Report
    • Invited
  • [Presentation] ヒト疾患とrare variants2015

    • Author(s)
      松本 直通
    • Organizer
      第33回内分泌代謝学サマーセミナー・続・内分泌至上主義・シンポジスト
    • Place of Presentation
      柳川藩主立花邸(福岡県柳川市)
    • Year and Date
      2015-07-09
    • Related Report
      2015 Annual Research Report
    • Invited
  • [Presentation] Computational Approaches to Coupled Folding and Binding in Protein-Protein Interactions2015

    • Author(s)
      Haruki Nakamura
    • Organizer
      19th KPPS (Korean Peptide Protein Symposium) Symposium
    • Place of Presentation
      泰安郡(韓国)
    • Year and Date
      2015-07-07
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] ヘムの構造歪みが酸化還元電位に与える影響の計算科学的研究2015

    • Author(s)
      今田康博, 中村春木, 鷹野優
    • Organizer
      第15回日本蛋白質科学会年会
    • Place of Presentation
      あわぎんホール(徳島県徳島市)
    • Year and Date
      2015-06-24
    • Related Report
      2015 Annual Research Report
  • [Presentation] p53蛋白質C末端天然変性領域の構造探索2015

    • Author(s)
      飯田慎仁, 神谷成敏, 北條裕信, 中村春木, 肥後順一
    • Organizer
      第15回日本蛋白質科学会年会
    • Place of Presentation
      あわぎんホール(徳島県徳島市)
    • Year and Date
      2015-06-24
    • Related Report
      2015 Annual Research Report
  • [Presentation] 転写因子Ets1とパートナー転写因子の協調的結合によるDNA結合活性制御機構の計算科学的検討2015

    • Author(s)
      笠原浩太, 福田育夫, 中村春木
    • Organizer
      第15回日本蛋白質科学会年会
    • Place of Presentation
      あわぎんホール(徳島県徳島市)
    • Year and Date
      2015-06-24
    • Related Report
      2015 Annual Research Report
  • [Presentation] FRET法とRAMD法を用いた核内受容体PPARγのリガンド結合に関する実験・理論的研究2015

    • Author(s)
      神谷成敏, Gert-Jan Bekker, 白木琢磨, 中村春木
    • Organizer
      第15回日本蛋白質科学会年会
    • Place of Presentation
      あわぎんホール(徳島県徳島市)
    • Year and Date
      2015-06-24
    • Related Report
      2015 Annual Research Report
  • [Presentation] Molecular Tailoring Approachによるタンパク質の二次構造に働く相互作用の量子化学的解析2015

    • Author(s)
      鷹野優, 草鹿あゆみ, 中村春木
    • Organizer
      第15回日本蛋白質科学会年会
    • Place of Presentation
      あわぎんホール(徳島県徳島市)
    • Year and Date
      2015-06-24
    • Related Report
      2015 Annual Research Report
  • [Presentation] HOMCOSサーバを用いた複合体立体構造の進化的保存性の解析2015

    • Author(s)
      川端猛, 中村春木
    • Organizer
      第15回日本蛋白質科学会年会
    • Place of Presentation
      あわぎんホール(徳島県徳島市)
    • Year and Date
      2015-06-24
    • Related Report
      2015 Annual Research Report
  • [Presentation] EMDBとPDBを対象とした形状類似性検索:Omokage検索2015

    • Author(s)
      鈴木博文, 川端猛, 中村春木
    • Organizer
      第15回日本蛋白質科学会年会
    • Place of Presentation
      あわぎんホール(徳島県徳島市)
    • Year and Date
      2015-06-24
    • Related Report
      2015 Annual Research Report
  • [Presentation] 全エクソーム解析データの様々な活用法2015

    • Author(s)
      松本 直通
    • Organizer
      2015アジレントゲノミクスフォーラム・招聘講演
    • Place of Presentation
      ヒューリックホール浅草橋(東京都台東区)
    • Year and Date
      2015-06-16
    • Related Report
      2015 Annual Research Report
    • Invited
  • [Presentation] IMiDs標的タンパク質CRBNの生化学的解析2015

    • Author(s)
      坂本 聡、伊藤 拓水、安藤 秀樹、山口 雄輝、半田 宏
    • Organizer
      日本ケミカルバイオロジー学会第10回年会
    • Place of Presentation
      東北大学(宮城県仙台市)
    • Year and Date
      2015-06-10
    • Related Report
      2015 Annual Research Report
  • [Presentation] Deep sequencing detects very low-grade somatic mosaicism in the unaffected mother of siblings with nemaline myopathy2015

    • Author(s)
      Naomichi Matsumoto, Eriko Koshimizu, Satoko Miyatake
    • Organizer
      European Human Genetics Conference 2015
    • Place of Presentation
      グラスゴー(イギリス)
    • Year and Date
      2015-06-06
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Prediction of protein-protein and protein-ligand interactions, and application to drug discovery2015

    • Author(s)
      Haruki Nakamura
    • Organizer
      The 9th Asian Biophysics Association Symposium (ABA2015)
    • Place of Presentation
      瀋陽(中国)
    • Year and Date
      2015-05-10
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] 遺伝性疾患の次世代シーケンス解析2015

    • Author(s)
      松本 直通
    • Organizer
      産総研Computational Biology Research Center (CBRC)セミナー
    • Place of Presentation
      産総研・臨海副都心センター別館(東京都江東区)
    • Year and Date
      2015-04-23
    • Related Report
      2015 Annual Research Report
    • Invited
  • [Presentation] Computational analysis on electrostatic properties of proteins and their assembly2015

    • Author(s)
      Haruki Nakamura
    • Organizer
      The first trilateral workshop for frontier protein studies
    • Place of Presentation
      北京(中国)
    • Year and Date
      2015-04-23
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] アフィニティビーズを利用した生物活性物質標的タンパク質の単離・同定・評価2015

    • Author(s)
      坂本 聡、山口 雄輝、半田 宏
    • Organizer
      日本薬学会第135年会
    • Place of Presentation
      神戸学院大学(兵庫県神戸市)
    • Year and Date
      2015-03-28
    • Related Report
      2014 Annual Research Report
  • [Presentation] DELLA-GAF1/IDD2複合体によるGA信号伝達とフィードバック制御機構2015

    • Author(s)
      深澤壽太郎、高橋陽介
    • Organizer
      第56回日本植物生理学会
    • Place of Presentation
      東京農業大学(東京都世田谷区)
    • Year and Date
      2015-03-18
    • Related Report
      2014 Annual Research Report
  • [Presentation] EPR1の新奇転写抑制モチーフの機能解析2015

    • Author(s)
      伊藤岳、高橋陽介
    • Organizer
      第56回日本植物生理学会
    • Place of Presentation
      東京農業大学(東京都世田谷区)
    • Year and Date
      2015-03-17
    • Related Report
      2014 Annual Research Report
  • [Presentation] 転写因子Ets1の天然変性領域によるDNA認識調節メカニズムに関する計算化学的検討2015

    • Author(s)
      笠原浩太
    • Organizer
      第3回天然変性蛋白質計算科学セミナー
    • Place of Presentation
      御殿場高原時之栖(静岡県御殿場市)
    • Year and Date
      2015-03-11
    • Related Report
      2014 Annual Research Report
  • [Presentation] DSIF and NELF interact with Integrator to specify the correct post-transcriptional fate of snRNA genes2015

    • Author(s)
      山本 淳一、半田 宏、山口 雄輝
    • Organizer
      冬の若手ワークショップ2015
    • Place of Presentation
      ホテル松本楼(群馬県渋川市)
    • Year and Date
      2015-02-06
    • Related Report
      2014 Annual Research Report
  • [Presentation] 転写伸長因子DSIFのリン酸化の転写伸長反応への寄与の解析2015

    • Author(s)
      磯部 智康、千葉 国俊、山口 雄輝
    • Organizer
      冬の若手ワークショップ2015
    • Place of Presentation
      ホテル松本楼(群馬県渋川市)
    • Year and Date
      2015-02-06
    • Related Report
      2014 Annual Research Report
  • [Presentation] 核内アクチンフィラメントの転写制御への関与とその分子機構の解析2014

    • Author(s)
      山崎 祥他, 山本 浩二、十川 久美子, 徳永 万喜洋, 原田 昌彦
    • Organizer
      第32回染色体ワークショップ・第13回核ダイナミクス研究会
    • Place of Presentation
      安芸グランドホテル(広島県廿日市市)
    • Year and Date
      2014-12-15 – 2014-12-17
    • Related Report
      2014 Annual Research Report
  • [Presentation] 個別化医療を進めるために2014

    • Author(s)
      松本 直道
    • Organizer
      日本遺伝子診療学会:遺伝子診断・検査技術推進フォーラム公開シンポジウム2014)
    • Place of Presentation
      コクヨホール(東京都港区)
    • Year and Date
      2014-12-12
    • Related Report
      2014 Annual Research Report
  • [Presentation] Coffin-Siris症候群の新規遺伝子探索2014

    • Author(s)
      松本 直道
    • Organizer
      NCNP(精神・神経疾患研究開発費(後藤班)平成26年度報告会
    • Place of Presentation
      NCNP(東京都小平市)
    • Year and Date
      2014-12-09
    • Related Report
      2014 Annual Research Report
    • Invited
  • [Presentation] TUBB4A変異による先天性白質形成不全症2014

    • Author(s)
      松本 直道
    • Organizer
      NCNP(精神・神経疾患研究開発費(佐々木班)平成26年度報告会
    • Place of Presentation
      NCNP(東京都小平市)
    • Year and Date
      2014-11-30
    • Related Report
      2014 Annual Research Report
    • Invited
  • [Presentation] “Congenital intellectual disability syndromes arising from mutations of epigenetic regulators”in the symposium for epigenetic dysregulation and disease2014

    • Author(s)
      松本 直道
    • Organizer
      The 37th annual meeting of the molecular biology society of Japan
    • Place of Presentation
      パシフィコ横浜(神奈川県横浜市)
    • Year and Date
      2014-11-27
    • Related Report
      2014 Annual Research Report
  • [Presentation] 発癌誘導に関与するヒストンH2A変異体の解析2014

    • Author(s)
      相原 仁, 水崎 博文, 中川 武弥, 伊藤 敬
    • Organizer
      第37回日本分子生物学会年会
    • Place of Presentation
      パシフィコ横浜(神奈川県横浜市)
    • Year and Date
      2014-11-27
    • Related Report
      2014 Annual Research Report
  • [Presentation] ジベレリン信号伝達に関与するカルシウム依存性タンパク質リン酸化酵素NtCDPK1の自己リン酸化による機能制御の解析2014

    • Author(s)
      伊藤岳、高橋陽介
    • Organizer
      第37回日本分子生物学会
    • Place of Presentation
      パシフィコ横浜(神奈川県横浜市)
    • Year and Date
      2014-11-25 – 2014-11-27
    • Related Report
      2014 Annual Research Report
  • [Presentation] Kinetic characterization of a DNA binding activity of the transcription factor Ets1 and its regulation by phosphorylation at an intrinsically disordered region2014

    • Author(s)
      Shiina M, Hamada K, Bungo-Inoue T, Shimamura M, Uchiyama A, Baba S, Sato K, Suzuki K, Yamamoto M, Ogata K
    • Organizer
      第37回日本分子生物学会年会
    • Place of Presentation
      パシフィコ横浜(神奈川県横浜市)
    • Year and Date
      2014-11-25 – 2014-11-27
    • Related Report
      2014 Annual Research Report
  • [Presentation] Orientation of Ets1 and Runx1 binding sites on enhancers and their cooperative regulation2014

    • Author(s)
      Uchiyama A, Shiina M, Hamada K, Bungo T, Shimamura M, Ogata K
    • Organizer
      第37回日本分子生物学会年会
    • Place of Presentation
      パシフィコ横浜(神奈川県横浜市)
    • Year and Date
      2014-11-25 – 2014-11-27
    • Related Report
      2014 Annual Research Report
  • [Presentation] Structure-based analysis for DNA recognition mechanism of the Nrf2-containing transcription factor heterodimer2014

    • Author(s)
      Suzuki K, Shiina M, Hamada K, Bungo T, Okada C, Baba S, Ohta T, Ogata K
    • Organizer
      第37回日本分子生物学会年会
    • Place of Presentation
      パシフィコ横浜(神奈川県横浜市)
    • Year and Date
      2014-11-25 – 2014-11-27
    • Related Report
      2014 Annual Research Report
  • [Presentation] Microtubules Instability and Dynamics Mediated by CLIP-170 in T Cells2014

    • Author(s)
      Wei Ming Lim,伊藤 由馬, 十川 久美子, 徳永 万喜洋
    • Organizer
      第37回日本分子生物学会年会
    • Place of Presentation
      パシフィコ横浜(神奈川県横浜市)
    • Year and Date
      2014-11-25 – 2014-11-27
    • Related Report
      2014 Annual Research Report
  • [Presentation] Live cell single-molecule imaging of T cell receptor and microcluster with planar lipid bilayers2014

    • Author(s)
      伊藤 由馬, 十川 久美子, 徳永 万喜洋
    • Organizer
      第37回日本分子生物学会年会
    • Place of Presentation
      パシフィコ横浜(神奈川県横浜市)
    • Year and Date
      2014-11-25 – 2014-11-27
    • Related Report
      2014 Annual Research Report
  • [Presentation] E3ユビキチンリガーゼの基質認識レセプター CRBNとポマリドマイド依存的な基質Aiolosの生化学的解析2014

    • Author(s)
      片山 美樹,伊藤 拓水,安藤 秀樹,山口 雄輝,半田 宏
    • Organizer
      第37回日本分子生物学会年会
    • Place of Presentation
      パシフィコ横浜(神奈川県横浜市)
    • Year and Date
      2014-11-25
    • Related Report
      2014 Annual Research Report
  • [Presentation] Histone H2A Thr 120 phosphorylation results in cancer via up regulation of Cyclin D12014

    • Author(s)
      Hirofumi Mizusaki, Hitoshi Aihara, Takashi Ito
    • Organizer
      第37回日本分子生物学会年会
    • Place of Presentation
      パシフィコ横浜(神奈川県横浜市)
    • Year and Date
      2014-11-25
    • Related Report
      2014 Annual Research Report
  • [Presentation] Dzip3はマウスES細胞において分化に関与する様々な遺伝子を調節する2014

    • Author(s)
      井上 大嗣, 相原 仁, 水崎 博文, 土井口 真康, 中山 敏幸, 中川 武弥, 伊藤 敬
    • Organizer
      第37回日本分子生物学会年会
    • Place of Presentation
      パシフィコ横浜(神奈川県横浜市)
    • Year and Date
      2014-11-25
    • Related Report
      2014 Annual Research Report
  • [Presentation] Regulatory Mechanisms for Pol II Termination Sites and 3' Processing Pathways in Higher Eukaryotes2014

    • Author(s)
      山口雄輝、山本淳一
    • Organizer
      転写サイクル国際シンポジウム2014
    • Place of Presentation
      東工大蔵前会館(東京都目黒区)
    • Year and Date
      2014-11-24
    • Related Report
      2014 Annual Research Report
  • [Presentation] 人類遺伝学研究におけるデータベースの重要性2014

    • Author(s)
      松本 直道
    • Organizer
      日本人類遺伝学会第59回大会・松本直通・NPGランチョンセミナー
    • Place of Presentation
      タワーホール船堀・東京(東京都江戸川区)
    • Year and Date
      2014-11-22
    • Related Report
      2014 Annual Research Report
  • [Presentation] 次世代シーケンサーを用いた染色体・ゲノム構造異常解析2014

    • Author(s)
      松本 直道
    • Organizer
      日本人類遺伝学会第59回大会
    • Place of Presentation
      タワーホール船堀・東京(東京都江戸川区)
    • Year and Date
      2014-11-21
    • Related Report
      2014 Annual Research Report
    • Invited
  • [Presentation] 次世代シーケンサーによる遺伝子解析2014

    • Author(s)
      松本 直道
    • Organizer
      第56回日本先天代謝異常学会総会
    • Place of Presentation
      江陽グランドホテル・仙台(宮城県仙台市)
    • Year and Date
      2014-11-14
    • Related Report
      2014 Annual Research Report
  • [Presentation] 次世代シーケンサーの活用法2014

    • Author(s)
      松本 直道
    • Organizer
      第17回胎児遺伝子診断研究会
    • Place of Presentation
      長崎ハウステンボス(長崎県佐世保市)
    • Year and Date
      2014-11-07
    • Related Report
      2014 Annual Research Report
  • [Presentation] Zero-dipole summation法を用いたエンハンソソーム制御メカニズムの分子動力学的解析2014

    • Author(s)
      笠原浩太、福田育夫
    • Organizer
      第1回「京」を中核とするHPCIシステム利用研究課題成果報告会
    • Place of Presentation
      コクヨホール(東京都港区)
    • Year and Date
      2014-10-31
    • Related Report
      2014 Annual Research Report
  • [Presentation] DELLA-GAF1複合体によるGA信号伝達とフィードバック制御機構の解析2014

    • Author(s)
      深澤壽太郎、高橋陽介
    • Organizer
      第49回植物化学調節学会
    • Place of Presentation
      京都大学(京都府京都市)
    • Year and Date
      2014-10-19
    • Related Report
      2014 Annual Research Report
  • [Presentation] ヒストンシャペロンNap1の構造解析2014

    • Author(s)
      浜田恵輔,椎名政昭,中島理沙,斎藤 誠,伊藤 敬,緒方一博
    • Organizer
      第87回日本生化学会大会
    • Place of Presentation
      国立京都国際会館(京都府京都市)
    • Year and Date
      2014-10-15 – 2014-10-18
    • Related Report
      2014 Annual Research Report
  • [Presentation] Analysis of the function of nuclear actin in cell differentiation2014

    • Author(s)
      山本 浩志, 山崎 祥他, 十川 久美子, 徳永 万喜洋, 原田 昌彦
    • Organizer
      第87回日本生化学会大会
    • Place of Presentation
      国立京都国際会館・グランドプリンスホテル京都(京都府京都市)
    • Year and Date
      2014-10-15 – 2014-10-18
    • Related Report
      2014 Annual Research Report
  • [Presentation] Functional regulation of the dynamics of actin in the nucleus2014

    • Author(s)
      山崎 祥他, 十川 久美子, 徳永 万喜洋, 原田 昌彦
    • Organizer
      第87回日本生化学会大会
    • Place of Presentation
      国立京都国際会館・グランドプリンスホテル京都(京都府京都市)
    • Year and Date
      2014-10-15 – 2014-10-18
    • Related Report
      2014 Annual Research Report
  • [Presentation] 分子動力学シミュレーション解析のためのMulti-modal Dynamic Cross Correlation法の開発と応用2014

    • Author(s)
      笠原浩太、福田育夫、中村春木
    • Organizer
      第3回生命医薬情報学連合大会
    • Place of Presentation
      仙台国際センター(宮城県仙台市)
    • Year and Date
      2014-10-02
    • Related Report
      2014 Annual Research Report
  • [Presentation] Segmentation & fitting algorithm for multiple submit fitting into a low resolution density map2014

    • Author(s)
      Takeshi Kawabata, Hirofumi Suzuki, Haruki Nakamura
    • Organizer
      第52回日本生物物理学会年会
    • Place of Presentation
      札幌コンベンションセンター(北海道札幌市)
    • Year and Date
      2014-09-27
    • Related Report
      2014 Annual Research Report
  • [Presentation] Theoretical analysis of molecular interactions in secondary structures of proteins2014

    • Author(s)
      Yu Takano, Ayumi Kusaka, Haruki Nakamura
    • Organizer
      第52回日本生物物理学会年会
    • Place of Presentation
      札幌コンベンションセンター(北海道札幌市)
    • Year and Date
      2014-09-27
    • Related Report
      2014 Annual Research Report
  • [Presentation] Contact number diffusion model for the normal mode analysis of protein structure2014

    • Author(s)
      Bhaskar Dasgupta, Kota Kasahara, Narutoshi Kamiya, Haruki Nakamura, Akira Kinjo
    • Organizer
      第52回日本生物物理学会年会
    • Place of Presentation
      札幌コンベンションセンター(北海道札幌市)
    • Year and Date
      2014-09-26
    • Related Report
      2014 Annual Research Report
  • [Presentation] Formation of microclusters of receptor molecules improves signal/noise ratio in cellular signal transduction2014

    • Author(s)
      深川 暁宏, 十川 久美子, 徳永 万喜洋
    • Organizer
      第52回日本生物物理学会年会
    • Place of Presentation
      札幌コンベンションセンター(北海道札幌市)
    • Year and Date
      2014-09-25 – 2014-09-27
    • Related Report
      2014 Annual Research Report
  • [Presentation] Single molecule imaging and quantitative analysis of dynamics of negative elongation factor NELF2014

    • Author(s)
      池田 大地, 伊藤 由馬, 徳永 万喜洋, 十川 久美子
    • Organizer
      第52回日本生物物理学会年会
    • Place of Presentation
      札幌コンベンションセンター(北海道札幌市)
    • Year and Date
      2014-09-25 – 2014-09-27
    • Related Report
      2014 Annual Research Report
  • [Presentation] Studies of dynamic chromatin structure and function to understand fundamentals of life2014

    • Author(s)
      十川 久美子, 伊藤 由馬, 深川 暁宏, 原田 昌彦, 木村 宏, 徳永 万喜洋
    • Organizer
      第52回日本生物物理学会年会
    • Place of Presentation
      札幌コンベンションセンター(北海道札幌市)
    • Year and Date
      2014-09-25 – 2014-09-27
    • Related Report
      2014 Annual Research Report
    • Invited
  • [Presentation] The elucidation of the molecular mechanism of PDLIM2 activation2014

    • Author(s)
      鳥山 悟, 伊藤 由馬, 田中 貴志, 徳永 万喜洋, 十川 久美子
    • Organizer
      第52回日本生物物理学会年会
    • Place of Presentation
      札幌コンベンションセンター(北海道札幌市)
    • Year and Date
      2014-09-25 – 2014-09-27
    • Related Report
      2014 Annual Research Report
  • [Presentation] A series of GECO mutants suitable for calcium imaging in a wide range of calcium concentration2014

    • Author(s)
      大木 杜生, 伊藤 由馬, 徳永 万喜洋, 十川 久美子
    • Organizer
      第52回日本生物物理学会年会
    • Place of Presentation
      札幌コンベンションセンター(北海道札幌市)
    • Year and Date
      2014-09-25 – 2014-09-27
    • Related Report
      2014 Annual Research Report
  • [Presentation] T cell receptor on the surface of living cells changes in the dynamics inside microclusters revealed by single-molecule imaging analysis2014

    • Author(s)
      伊藤 由馬, 十川 久美子, 徳永 万喜洋
    • Organizer
      第52回日本生物物理学会年会
    • Place of Presentation
      札幌コンベンションセンター(北海道札幌市)
    • Year and Date
      2014-09-25 – 2014-09-27
    • Related Report
      2014 Annual Research Report
  • [Presentation] Free-energy landscape of C-terminal negative regulatory domain of p532014

    • Author(s)
      Shinji Iida, Haruki Nakamura, Junini Higo
    • Organizer
      第52回日本生物物理学会年会
    • Place of Presentation
      札幌コンベンションセンター(北海道札幌市)
    • Year and Date
      2014-09-25
    • Related Report
      2014 Annual Research Report
  • [Presentation] Computational study of the electronic structures of hemes in cytochrome c32014

    • Author(s)
      Yasuhiro Imada, Haruki Nakamura, Yu Takano
    • Organizer
      第52回日本生物物理学会年会
    • Place of Presentation
      札幌コンベンションセンター(北海道札幌市)
    • Year and Date
      2014-09-25
    • Related Report
      2014 Annual Research Report
  • [Presentation] Elastic properties of dynein motor domain obatined from all-atom molecular dynamics simulations in explicit water2014

    • Author(s)
      Narutoshi Kamiya, Tadaaki Mashimo, Yu Takano, Takahide Kon, Genji Kurisu, Haruki Nakamura
    • Organizer
      第52回日本生物物理学会年会
    • Place of Presentation
      札幌コンベンションセンター(北海道札幌市)
    • Year and Date
      2014-09-25
    • Related Report
      2014 Annual Research Report
  • [Presentation] Molecular dynamics study on cooperative binding of Ets1 and partner transcription factors on regulatory elements2014

    • Author(s)
      Kota Kasahara, Ikuo Fukuda, Haruki Nakamura
    • Organizer
      第52回日本生物物理学会年会
    • Place of Presentation
      札幌コンベンションセンター(北海道札幌市)
    • Year and Date
      2014-09-25
    • Related Report
      2014 Annual Research Report
  • [Presentation] Histone H2A Thr 120 phosphorylation results in cancer via up regulation of Cyclin D12014

    • Author(s)
      Hirofumi Mizusaki, Hitoshi Aihara, Takashi Ito
    • Organizer
      Cold Spring Harbor Laboratory Meeting & Courses Epigenetics & Chromatin
    • Place of Presentation
      コールドスプリングハーバー(アメリカ)
    • Year and Date
      2014-09-10
    • Related Report
      2014 Annual Research Report
  • [Presentation] Histone H2A Mutation Might Play Roles in Carcinogenesis2014

    • Author(s)
      Hitoshi Aihara, Hirofumi Mizusaki, Takeya Nakagawa, Takashi Ito
    • Organizer
      Cold Spring Harbor Laboratory Meeting & Courses Epigenetics & Chromatin
    • Place of Presentation
      コールドスプリングハーバー(アメリカ)
    • Year and Date
      2014-09-10
    • Related Report
      2014 Annual Research Report
  • [Presentation] ゲノム解析と医療--1000ドルゲノム時代を迎えて--2014

    • Author(s)
      松本 直道
    • Organizer
      KOBE内分泌・代謝スキルアップセミナー特別講演
    • Place of Presentation
      ホテルクラウンパレス神戸(兵庫県神戸市)
    • Year and Date
      2014-08-23
    • Related Report
      2014 Annual Research Report
  • [Presentation] A new non-Ewald scheme for molecular dynamics simulation and its application to a free energy landscape for protein-protein interaction2014

    • Author(s)
      Haruki Nakamura
    • Organizer
      2nd International Conference on Computational Science and Engineering (ICCSE 2014)
    • Place of Presentation
      ホーチミン(ベトナム)
    • Year and Date
      2014-08-23
    • Related Report
      2014 Annual Research Report
    • Invited
  • [Presentation] ヒト発生・発達異常の分子探索と診断法の開発2014

    • Author(s)
      松本 直道
    • Organizer
      文部科学省イノベーションシステム整備事業先端融合領域イノベーション創出拠点形成プログラム「翻訳後修飾プロテオミクス医療研究拠点の形成」第5回公開シンポジウム
    • Place of Presentation
      県民共済みなとみらいホール(神奈川県横浜市)
    • Year and Date
      2014-08-19
    • Related Report
      2014 Annual Research Report
    • Invited
  • [Presentation] 難病を解き明かすヒト全遺伝子・全ゲノム解析2014

    • Author(s)
      松本 直道
    • Organizer
      横浜市立大学先端医科学研究センター市民講座
    • Place of Presentation
      ウイング横浜(神奈川県横浜市)
    • Year and Date
      2014-08-07
    • Related Report
      2014 Annual Research Report
    • Invited
  • [Presentation] 転写伸長因子DSIFにリン酸化依存的に相互作用する因子の機能解析2014

    • Author(s)
      磯部 智康、千葉 国俊、山口 雄輝
    • Organizer
      転写サイクル班会議2014
    • Place of Presentation
      慶山(山梨県笛吹市)
    • Year and Date
      2014-08-05
    • Related Report
      2014 Annual Research Report
  • [Presentation] DSIF and NELF interact with Integrator to specify the correct post-transcriptional fate of snRNA genes2014

    • Author(s)
      山本淳一、半田宏、山口雄輝
    • Organizer
      転写サイクル班会議2014
    • Place of Presentation
      慶山(山梨県笛吹市)
    • Year and Date
      2014-08-05
    • Related Report
      2014 Annual Research Report
  • [Presentation] 転写伸長因子DSIFおよびNELFがES細胞の多分化能維持に果たす役割2014

    • Author(s)
      柴田 紘孝、半田 宏、山口 雄輝
    • Organizer
      転写サイクル班会議2014
    • Place of Presentation
      慶山(山梨県笛吹市)
    • Year and Date
      2014-08-05
    • Related Report
      2014 Annual Research Report
  • [Presentation] 新規転写伸長因子ヒトRtf1が関与する転写制御の分子機構2014

    • Author(s)
      曹 青福、陳 業熹、半田 宏、山口 雄輝
    • Organizer
      転写サイクル班会議2014
    • Place of Presentation
      慶山(山梨県笛吹市)
    • Year and Date
      2014-08-05
    • Related Report
      2014 Annual Research Report
  • [Presentation] ヒトRNA ポリメラーゼII 転写産物のプロセシング経路の選択機構2014

    • Author(s)
      山口 雄輝、山本 淳一、半田 宏
    • Organizer
      転写サイクル班会議2014
    • Place of Presentation
      慶山(山梨県笛吹市)
    • Year and Date
      2014-08-04
    • Related Report
      2014 Annual Research Report
  • [Presentation] GAF1, A DELLA INTERACTING PROTEIN, REGULATES GIBBERELLIN HOMEOSTASIS AND SIGNALING2014

    • Author(s)
      Fukazawa, J., Takahasi, Y.
    • Organizer
      25th International Conference on Arabidopsis Research
    • Place of Presentation
      バンクーバー(カナダ)
    • Year and Date
      2014-07-28 – 2014-08-01
    • Related Report
      2014 Annual Research Report
  • [Presentation] 共用スパコンを用いた分子動力学シミュレーション研究2014

    • Author(s)
      笠原浩太
    • Organizer
      国立遺伝学研究所スーパーコンピュータユーザ会
    • Place of Presentation
      国立遺伝学研究所(静岡県三島市)
    • Year and Date
      2014-07-22
    • Related Report
      2014 Annual Research Report
  • [Presentation] Scaffold function of Ca2+-dependent protein kinase: NtCDPK1 transfers 14-3-3 to the substrate RSG after phosphorylation2014

    • Author(s)
      Ito, T., Takahashi, Y.
    • Organizer
      Plant Biology 2014
    • Place of Presentation
      ポートランド(アメリカ)
    • Year and Date
      2014-07-12 – 2014-07-16
    • Related Report
      2014 Annual Research Report
  • [Presentation] 遺伝性疾患のゲノム解析---1000ドルゲノム時代を迎えて---2014

    • Author(s)
      松本 直道
    • Organizer
      がん研臨床試験・研究センター 第12回臨床研究セミナー
    • Place of Presentation
      がん研究会(東京都江東区)
    • Year and Date
      2014-07-03
    • Related Report
      2014 Annual Research Report
  • [Presentation] 発達障害のゲノム解析2014

    • Author(s)
      松本 直道
    • Organizer
      第110回日本精神神経学会学術総会
    • Place of Presentation
      パシフィコ横浜(神奈川県横浜市)
    • Year and Date
      2014-06-27
    • Related Report
      2014 Annual Research Report
  • [Presentation] fkcombu:2D-MCSを用いた鋳型ベースの低分子化合物ドッキング法の開発2014

    • Author(s)
      川端猛、中村春木
    • Organizer
      第14回日本蛋白質科学会年会
    • Place of Presentation
      ワークピア横浜(神奈川県横浜市)
    • Year and Date
      2014-06-27
    • Related Report
      2014 Annual Research Report
  • [Presentation] 抗原抗体ドッキングのデコイセット評価法2014

    • Author(s)
      榛葉教子、神谷成敏、中村春木
    • Organizer
      第14回日本蛋白質科学会年会
    • Place of Presentation
      ワークピア横浜(神奈川県横浜市)
    • Year and Date
      2014-06-26
    • Related Report
      2014 Annual Research Report
  • [Presentation] Cytochrome c3中のヘムの電子構造制御に関する計算科学的研究2014

    • Author(s)
      今田康博、中村春木、鷹野優
    • Organizer
      第14回日本蛋白質科学会年会
    • Place of Presentation
      ワークピア横浜(神奈川県横浜市)
    • Year and Date
      2014-06-26
    • Related Report
      2014 Annual Research Report
  • [Presentation] Regulation of DNA binding of Ets1 by phosphorylation in an intrinsic disordered region2014

    • Author(s)
      椎名政昭,浜田恵輔,井上-豊後泰子,嶋村麻利子,馬場しほ,内山晃子,鈴木香絵,タヒロフ タヒール,緒方一博
    • Organizer
      第14回日本蛋白質科学会年会
    • Place of Presentation
      ワークピア横浜(神奈川県横浜市)
    • Year and Date
      2014-06-25 – 2014-06-27
    • Related Report
      2014 Annual Research Report
    • Invited
  • [Presentation] 蛋白質の二次構造形成に関わる相互作用に関する理論的研究2014

    • Author(s)
      鷹野優、中村春木
    • Organizer
      第14回日本蛋白質科学会年会
    • Place of Presentation
      ワークピア横浜(神奈川県横浜市)
    • Year and Date
      2014-06-25
    • Related Report
      2014 Annual Research Report
    • Invited
  • [Presentation] Free-energy landscape of the C-terminal negative regulatory domain of p532014

    • Author(s)
      Sinji Iida, Haruki Nakamura, Junichi Higo
    • Organizer
      第14回日本蛋白質科学会年会
    • Place of Presentation
      ワークピア横浜(神奈川県横浜市)
    • Year and Date
      2014-06-25
    • Related Report
      2014 Annual Research Report
  • [Presentation] 分子動力学法に基づいた新しい動的相関解析手法の開発と転写因子Ets-1-DNA結合機構解析への応用2014

    • Author(s)
      笠原浩太、福田育夫、中村春木
    • Organizer
      第14回日本蛋白質科学会年会
    • Place of Presentation
      ワークピア横浜(神奈川県横浜市)
    • Year and Date
      2014-06-25
    • Related Report
      2014 Annual Research Report
  • [Presentation] ゲノム解析と医療:1000ドルゲノム時代を迎えて2014

    • Author(s)
      松本 直道
    • Organizer
      藤田保健衛生大学遺伝子網羅的解析センター開所記念セミナー・特別講演
    • Place of Presentation
      藤田保健衛生大学(愛知県豊明市)
    • Year and Date
      2014-06-21
    • Related Report
      2014 Annual Research Report
  • [Presentation] New Non-Ewald Scheme for Molecular Dynamics Simulation and Application to Free Energy Calculation2014

    • Author(s)
      Haruki Nakamura
    • Organizer
      Bioinformatics in Torun 2014 (BIT14)
    • Place of Presentation
      Torun(Poland)
    • Year and Date
      2014-06-12
    • Related Report
      2014 Annual Research Report
    • Invited
  • [Presentation] 抗炎症薬サリチル酸の生体内作用機構の解析2014

    • Author(s)
      坂本 聡、Vipul Gupta、劉 舒捷、安藤 秀樹、舘野 峻平、金子 裕生、湯上 真人、石井 亮平、濡木 理、山口 雄輝、半田 宏
    • Organizer
      日本ケミカルバイオロジー学会第9回年会
    • Place of Presentation
      大阪大学(大阪府豊中市)
    • Year and Date
      2014-06-11
    • Related Report
      2014 Annual Research Report
  • [Presentation] Neurodegeneration with Brain Iron Accumulation (NBIA): 急速に広がる疾患概念2014

    • Author(s)
      松本 直道
    • Organizer
      第55回日本神経病理学会総会学術集会
    • Place of Presentation
      学術総合センター(東京都千代田区)
    • Year and Date
      2014-06-07
    • Related Report
      2014 Annual Research Report
  • [Presentation] ゲノム解析と医療:1000ドルゲノムシーケンス時代を迎えて2014

    • Author(s)
      松本 直道
    • Organizer
      信州大学先鋭領域融合研究群バイオメディカル研究所設立記念講演会・記念講演会
    • Place of Presentation
      信州大学医学部(長野県松本市)
    • Year and Date
      2014-05-25
    • Related Report
      2014 Annual Research Report
  • [Presentation] ゲノム解析と医療:1000ドルゲノム時代を迎えて2014

    • Author(s)
      松本 直道
    • Organizer
      九州大学産婦人科セミナー
    • Place of Presentation
      第二博多偕成ビルアイクレオ(福岡県福岡市)
    • Year and Date
      2014-05-21
    • Related Report
      2014 Annual Research Report
  • [Presentation] New Approach to Electrostatic Properties of Proteins and Protein-Protein Interactions2014

    • Author(s)
      Haruki Nakamura
    • Organizer
      The 4th Asia Pacific Protein Association (APPA 2014)
    • Place of Presentation
      済州島(韓国)
    • Year and Date
      2014-05-18
    • Related Report
      2014 Annual Research Report
    • Invited
  • [Presentation] Molecular dynamics study on enhancer recognitions by cooperative binding of Ets1 and partner transcription factors2014

    • Author(s)
      笠原浩太、福田育夫、中村春木
    • Organizer
      The 4th Asia Pacific Protein Association (APPA 2014)
    • Place of Presentation
      済州島(韓国)
    • Year and Date
      2014-05-18
    • Related Report
      2014 Annual Research Report
  • [Presentation] 植物の新奇転写抑制モチーフ –真核生物に保存された転写抑制機構の解析2014

    • Author(s)
      岡村僚太、高橋陽介
    • Organizer
      第71回中国四国植物学会
    • Place of Presentation
      岡山理科大学(岡山県岡山市)
    • Year and Date
      2014-05-10
    • Related Report
      2014 Annual Research Report
  • [Presentation] 翻訳後修飾によるジベレリン信号伝達制御の解析2014

    • Author(s)
      三島由佳、高橋陽介
    • Organizer
      第71回中国四国植物学会
    • Place of Presentation
      岡山理科大学(岡山県岡山市)
    • Year and Date
      2014-05-10
    • Related Report
      2014 Annual Research Report
  • [Presentation] 遺伝性疾患におけるエクソーム解析の有用性2014

    • Author(s)
      松本 直道
    • Organizer
      第382回医学研究の基礎を語り合う集い
    • Place of Presentation
      東京慈恵医科大学(東京都港区)
    • Year and Date
      2014-04-21
    • Related Report
      2014 Annual Research Report
  • [Presentation] Next generation sequencing dissecting human genetic diseases2014

    • Author(s)
      松本 直道
    • Organizer
      The 9th Cherry Blossom Symposium
    • Place of Presentation
      横浜赤レンガ倉庫(神奈川県横浜市)
    • Year and Date
      2014-04-19
    • Related Report
      2014 Annual Research Report
  • [Presentation] 次世代シーケンサー解析のポテンシャルと小児医療2014

    • Author(s)
      松本 直通
    • Organizer
      第37回日本小児遺伝学会学術集会・シンポジウム
    • Place of Presentation
      名古屋市立大学桜山キャンパス(愛知県名古屋市)
    • Year and Date
      2014-04-10
    • Related Report
      2014 Annual Research Report
  • [Presentation] Quantitative imaging analysis of molecular dynamics of actin-related protein in the nucleus2014

    • Author(s)
      Yuma Ito, Naomichi Inaba, Masahiko Harata, Hiroshi Kimura, Makio Tokunaga, Kumiko Sakata-Sogawa
    • Organizer
      58th Annual Meeting of Biophysical Society
    • Place of Presentation
      Moscone Center(米国カリフォルニア州)
    • Related Report
      2013 Annual Research Report
  • [Presentation] Molecular imaging analysis of regulatory mechanism of inflammatory response2014

    • Author(s)
      Yuma Ito, Jun Takimoto, Takashi Tanaka, Tsuneyasu Kaisho, Makio Tokunaga, Kumiko Sakata-Sogawa
    • Organizer
      58th Annual Meeting of Biophysical Society
    • Place of Presentation
      Moscone Center(米国カリフォルニア州)
    • Related Report
      2013 Annual Research Report
  • [Presentation] 複数のChIP-Seqデータの統合解析手法の検討2014

    • Author(s)
      藤井 聡、西山 晃、田村 智彦
    • Organizer
      冬の若手ワークショップ2014
    • Place of Presentation
      舌切雀のお宿 磯部ガーデン(群馬県)
    • Related Report
      2013 Annual Research Report
  • [Presentation] 転写因子Ets1のDNA結合制御に関する分子シミュレーション研究2014

    • Author(s)
      笠原 浩太,福田 育夫,中村 春木
    • Organizer
      冬の若手ワークショップ2014
    • Place of Presentation
      舌切雀のお宿 磯部ガーデン(群馬県)
    • Related Report
      2013 Annual Research Report
  • [Presentation] Cellecta社製プール型レンチウイルスshRNAライブラリーを用いたスクリーニングデータ解析法の検討2014

    • Author(s)
      飯田 緑, 舘野 峻平, 山口 雄輝, 藤井 聡
    • Organizer
      冬の若手ワークショップ2014
    • Place of Presentation
      舌切雀のお宿 磯部ガーデン(群馬県)
    • Related Report
      2013 Annual Research Report
  • [Presentation] Transcriptome analysis of red seabream (Pagrus major) embryos treated with 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD)2014

    • Author(s)
      M. Iida, S. Fujii, M. Uchida, H. Nakamura, Y. Kagami, S.M. Bak, E.Y. Kim, Y. Shima, H. Iwata
    • Organizer
      Society of Toxicology
    • Place of Presentation
      Phoenix Convention Center(米国アリゾナ州)
    • Related Report
      2013 Annual Research Report
  • [Presentation] ジベレリンの転写代謝システム及翻訳後修飾制御機構2014

    • Author(s)
      深澤壽太郎,森雅彦,増谷優次,宮本知佳,高橋陽介
    • Organizer
      冬の若手ワークショップ
    • Place of Presentation
      磯部ガーデン(群馬県)
    • Related Report
      2013 Annual Research Report
  • [Presentation] 植物の新奇転写抑制モチーフ –真核生物に保存された転写抑制機構の解析–2014

    • Author(s)
      伊藤岳,岡村僚太,佐久間哲史,山本卓,高橋陽介
    • Organizer
      第55回日本植物生理学会
    • Place of Presentation
      富山大学(富山県)
    • Related Report
      2013 Annual Research Report
  • [Presentation] ジベレリン生合成酵素遺伝子 AtGA20ox2 のフィードバック制御機構の解析2014

    • Author(s)
      森雅彦,渡辺哲史,深沢寿太郎,伊藤岳,高橋陽介
    • Organizer
      第55回日本植物生理学会
    • Place of Presentation
      富山大学(富山県)
    • Related Report
      2013 Annual Research Report
  • [Presentation] 分子シミュレーションにおける静電相互作用計算法について: Ewald, Non-Ewald, and Zero-dipole summation2013

    • Author(s)
      福田育夫
    • Organizer
      京阪奈計算生物物理セミナー
    • Place of Presentation
      京都大学(京都)
    • Year and Date
      2013-03-29
    • Related Report
      2012 Annual Research Report
    • Invited
  • [Presentation] ジベレリン信号伝達に関与するタンパク質リン酸化酵素NtCDPK1の自己リン酸化による機能制御の解析2013

    • Author(s)
      大江 翔太
    • Organizer
      第54回日本植物生理学会
    • Place of Presentation
      岡山大学(岡山)
    • Year and Date
      2013-03-22
    • Related Report
      2012 Annual Research Report
  • [Presentation] JAシグナルを負に制御するbHLH型転写因子JAM1の解析2013

    • Author(s)
      中田 克
    • Organizer
      第54回日本植物生理学会
    • Place of Presentation
      岡山大学(岡山)
    • Year and Date
      2013-03-22
    • Related Report
      2012 Annual Research Report
  • [Presentation] The mechanism of action of thalidomide, a drug with two faces2013

    • Author(s)
      Yamaguchi, Y.
    • Organizer
      International Marine Biotechnology Symposium 2013
    • Place of Presentation
      沖縄産業支援センター(沖縄)
    • Year and Date
      2013-03-18
    • Related Report
      2012 Annual Research Report
    • Invited
  • [Presentation] Single molecule imaging in living cells and stochastic features of inter- and intra-molecular interactions.2013

    • Author(s)
      Makio Tokunaga
    • Organizer
      1st Bioscience and Biotechnology International symposium “Biomolecular assemblies from nano to micro”
    • Place of Presentation
      東京工業大学(神奈川)
    • Year and Date
      2013-01-30
    • Related Report
      2012 Annual Research Report
    • Invited
  • [Presentation] Drug Development for a GPCR with in-silico screening2013

    • Author(s)
      Haruki Nakamura
    • Organizer
      Nagoya Symposium, Frontiers in Structural Physiology
    • Place of Presentation
      名古屋大学(愛知)
    • Year and Date
      2013-01-24
    • Related Report
      2012 Annual Research Report
    • Invited
  • [Presentation] Computational Prediction and Analysis of Protein-Protein Interactions: Qualitative and Quantitative Approaches2013

    • Author(s)
      Haruki Nakamura
    • Organizer
      Special Seminar at Academia Sinica
    • Place of Presentation
      Academia Sinica, Shanghai
    • Year and Date
      2013-01-18
    • Related Report
      2012 Annual Research Report
    • Invited
  • [Presentation] A simple non-Ewald scheme for calculating electrostatic interactions of charged particle systems: the zero-dipole summation method and the application to molecular systems2013

    • Author(s)
      福田 育夫
    • Organizer
      2013年ハイパフォーマンスコンピューティングと計算科学シンポジウム
    • Place of Presentation
      東京工業大学(東京)
    • Year and Date
      2013-01-15
    • Related Report
      2012 Annual Research Report
  • [Presentation] GPUを利用したZero-dipole summation法による静電相互作用計算の高速化2013

    • Author(s)
      中村春木
    • Organizer
      2013年ハイパフォーマンスコンピューティングと計算科学シンポジウム
    • Place of Presentation
      東京工業大学(東京)
    • Year and Date
      2013-01-15
    • Related Report
      2012 Annual Research Report
  • [Presentation] A new non-Ewald scheme: The zero-dipole summation method and its applications to molecular dynamics simulations for homogeneous and inhomogeneous biomolecular systems2013

    • Author(s)
      Haruki Nakamura
    • Organizer
      National Symposium on Frontiers of Biophysics, Biotechnology Bioinformatics and 37'th Annual Meeting of Indian Biophysical Society
    • Place of Presentation
      University of Mumbai, India
    • Year and Date
      2013-01-14
    • Related Report
      2012 Annual Research Report
    • Invited
  • [Presentation] Prediction of protein-protein complex structures2013

    • Author(s)
      Haruki Nakamura
    • Organizer
      International Conference on Biomolecular Forms and Functions
    • Place of Presentation
      Indian Institute of Science Bangalore, India
    • Year and Date
      2013-01-10
    • Related Report
      2012 Annual Research Report
    • Invited
  • [Presentation] DSIF and NELF interact with Integrator and participate in 3’ processing of snRNA genes: A possible mechanism controlling the fate of Pol II2013

    • Author(s)
      Yamaguchi, Y., Yamamoto, J., and Handa, H.
    • Organizer
      CSHL Meeting on Mechanisms of Eukaryotic Transcription
    • Place of Presentation
      Cold Spring Harbor Laboratory(米国ニューヨーク州)
    • Related Report
      2013 Annual Research Report
  • [Presentation] The diverse pharmacological effects of thalidomide2013

    • Author(s)
      Yamaguchi, Y.
    • Organizer
      BioJapan 2013 World Business Forum
    • Place of Presentation
      パシフィコ横浜(神奈川県)
    • Related Report
      2013 Annual Research Report
    • Invited
  • [Presentation] 1分子研究が明かす動的でエントロピー的な分子間・分子内相互作用2013

    • Author(s)
      徳永万喜洋、深川暁弘、十川久美子
    • Organizer
      日本顕微鏡学会第69回学術講演会・シンポジウム“超解像顕微鏡技術と生物応用”
    • Place of Presentation
      ホテル阪急エキスポパーク(大阪府)
    • Related Report
      2013 Annual Research Report
  • [Presentation] Single molecule analysis of signaling membrane proteins in T cell microcluster by multicolor live cell imaging2013

    • Author(s)
      伊藤由馬、十川久美子、徳永万喜洋
    • Organizer
      第51回日本生物物理学会年会
    • Place of Presentation
      国立京都国際会館(京都府)
    • Related Report
      2013 Annual Research Report
  • [Presentation] FRET - based analysis of interactions between elongin B and elongin C2013

    • Author(s)
      大山浩史、伊藤由馬、十川久美子、徳永万喜洋
    • Organizer
      第51回日本生物物理学会年会
    • Place of Presentation
      国立京都国際会館(京都府)
    • Related Report
      2013 Annual Research Report
  • [Presentation] Quantification of calcium concentration in cells by imaging analysis using GEM-GECO.2013

    • Author(s)
      大木杜生、伊藤由馬、十川久美子、徳永万喜洋
    • Organizer
      第51回日本生物物理学会年会
    • Place of Presentation
      国立京都国際会館(京都府)
    • Related Report
      2013 Annual Research Report
  • [Presentation] Why do cells use signaling cascades with a variety of the number of steps?2013

    • Author(s)
      深川暁弘、梶田真司、十川久美子、徳永万喜洋
    • Organizer
      第51回日本生物物理学会年会
    • Place of Presentation
      国立京都国際会館(京都府)
    • Related Report
      2013 Annual Research Report
  • [Presentation] Quantitative molecular imaging analysis of molecular dynamics of Arp4β upon transcriptional activation.2013

    • Author(s)
      稲葉直道、伊藤由馬、原田昌彦、木村宏、徳永万喜洋、十川久美子
    • Organizer
      第51回日本生物物理学会年会
    • Place of Presentation
      国立京都国際会館(京都府)
    • Related Report
      2013 Annual Research Report
  • [Presentation] The elucidation of the mechanism of PDLIM2 localization regulation2013

    • Author(s)
      鳥山悟、伊藤由馬、徳永万喜洋、十川久美子
    • Organizer
      第51回日本生物物理学会年会
    • Place of Presentation
      国立京都国際会館(京都府)
    • Related Report
      2013 Annual Research Report
  • [Presentation] Structural analyses for the effects of Ets1 phosphorylation on Ets1-containing TF-DNA assemblies2013

    • Author(s)
      Shiina M
    • Organizer
      HUPO 2013(12th Human Proteome Organization Annual World Congress)
    • Place of Presentation
      パシフィコ横浜(神奈川県)
    • Related Report
      2013 Annual Research Report
  • [Presentation] Cooperative Formation of a Multiple Transcription Factor Assembly on an Enhancer DNA and Its Regulation by Phosphorylation of a Transcription Factor via a Cell Signaling2013

    • Author(s)
      Shiina M
    • Organizer
      HUPO 2013(12th Human Proteome Organization Annual World Congress)
    • Place of Presentation
      パシフィコ横浜(神奈川県)
    • Related Report
      2013 Annual Research Report
  • [Presentation] DNA-mediated allosteric regulation in a complex of multiple transcription factors with DNA2013

    • Author(s)
      Shiina M
    • Organizer
      4th International Symposium on Diffraction Structural Biology
    • Place of Presentation
      名古屋市中小企業振興会館(愛知県)
    • Related Report
      2013 Annual Research Report
  • [Presentation] Crystal structural analysis of drosophila nucleosome assembly protein2013

    • Author(s)
      Hamada K
    • Organizer
      4th International Symposium on Diffraction Structural Biology
    • Place of Presentation
      名古屋市中小企業振興会館(愛知県)
    • Related Report
      2013 Annual Research Report
  • [Presentation] Allosteric Regulation of a Multiple Transcription Factor Assembly on an Enhancer DNA2013

    • Author(s)
      Shiina M
    • Organizer
      第36回日本分子生物学会
    • Place of Presentation
      神戸ポートアイランド(兵庫県)
    • Related Report
      2013 Annual Research Report
  • [Presentation] Mechanisms of DNA recognition by the Nrf2-containing transcription factor heterodimer2013

    • Author(s)
      Suzuki K
    • Organizer
      第36回日本分子生物学会
    • Place of Presentation
      神戸ポートアイランド(兵庫県)
    • Related Report
      2013 Annual Research Report
  • [Presentation] The cooperative activity of Ets1 and Runx1 on various target gene enhancers and the effect of phosphorylation of Ets1 on the cooperation2013

    • Author(s)
      Uchiyama A
    • Organizer
      第36回日本分子生物学会
    • Place of Presentation
      神戸ポートアイランド(兵庫県)
    • Related Report
      2013 Annual Research Report
  • [Presentation] Mendelian Exome Analysis2013

    • Author(s)
      Naomichi Matsumoto
    • Organizer
      The 10th International Workshop on Advanced Genomics
    • Place of Presentation
      National Center of Sciences(東京都)
    • Related Report
      2013 Annual Research Report
    • Invited
  • [Presentation] De novo mutations in the autophagy gene encoding WDR45 (WIPI4) cause static encephalopathy of childhood with neurodegeneration in adulthood2013

    • Author(s)
      N. Matsumoto, T. Nishimura, K. Muramatsu, H. Kodera, S. Kumada, K. Sugai, E. Kasai-Yoshida, N. Sawaura, H. Nishida, A. Hoshino, F. Ryujin, S. Yoshioka, H. Arakawa, M. Kato, N. Mizushima, H. Saitsu
    • Organizer
      European Conference of Human Genetic 2013
    • Place of Presentation
      Palais des Congres(フランス・パリ)
    • Related Report
      2013 Annual Research Report
  • [Presentation] 次世代シーケンサーを用いてわかってきたこと2013

    • Author(s)
      松本直通
    • Organizer
      第17回小児分子内分泌研究会
    • Place of Presentation
      札幌北広島クラッセホテル(北海道)
    • Related Report
      2013 Annual Research Report
    • Invited
  • [Presentation] 疾患ゲノム解析における次世代シーケンサーの有用性2013

    • Author(s)
      松本直通
    • Organizer
      第20回日本遺伝子診療学会大会
    • Place of Presentation
      アクトシティ―浜松コングレスセンター(静岡県)
    • Related Report
      2013 Annual Research Report
    • Invited
  • [Presentation] 次世代シーケンサーを用いた疾患ゲノム解析2013

    • Author(s)
      松本直通
    • Organizer
      CiRA genomics epigenomics and bioinformatics seminar series VIII
    • Place of Presentation
      CiRA京都大学(京都府)
    • Related Report
      2013 Annual Research Report
    • Invited
  • [Presentation] NGSがもたらしたヒト疾患ゲノム解析のパラダイムシフト2013

    • Author(s)
      松本直通
    • Organizer
      現場の会第三回研究会
    • Place of Presentation
      神戸国際会議場(兵庫県)
    • Related Report
      2013 Annual Research Report
    • Invited
  • [Presentation] 次世代シーケンサーを用いた疾患ゲノム解析:現状と限界2013

    • Author(s)
      松本直通
    • Organizer
      第22回発達腎研究会
    • Place of Presentation
      高槻市生涯学習センター(大阪府)
    • Related Report
      2013 Annual Research Report
    • Invited
  • [Presentation] 次世代シーケンス解析で分かってきたこと2013

    • Author(s)
      松本直通
    • Organizer
      第18回山形小児神経研究会
    • Place of Presentation
      パレスグランデール(山形県)
    • Related Report
      2013 Annual Research Report
    • Invited
  • [Presentation] ヒト疾患エクソーム解析の現状と課題2013

    • Author(s)
      松本直通
    • Organizer
      第58回日本人類遺伝学会大会
    • Place of Presentation
      江陽グランドホテル仙台(宮城県)
    • Related Report
      2013 Annual Research Report
    • Invited
  • [Presentation] 希少疾患・難病の全エクソーム解析-現状と課題-2013

    • Author(s)
      松本直通
    • Organizer
      日経バイオテク「希少疾患・難病の治療薬開発におけるゲノム活用」
    • Place of Presentation
      秋葉原コンベンションホ―ル(東京都)
    • Related Report
      2013 Annual Research Report
    • Invited
  • [Presentation] ATP-Dependent Stimulator of Nucleosomal Histone Acetylation (ASNA) plays a role in transcriptional regulation together with CBP/p300.2013

    • Author(s)
      Takashi Ito
    • Organizer
      第36回日本分子生物学会年会
    • Place of Presentation
      神戸国際会議場(兵庫県)
    • Related Report
      2013 Annual Research Report
  • [Presentation] Measuring similarity of binding modes between 3D structures of protein-small ligand complexes2013

    • Author(s)
      笠原 浩太
    • Organizer
      JCUP IV
    • Place of Presentation
      大手町サンスカイルーム(東京都)
    • Related Report
      2013 Annual Research Report
  • [Presentation] All-atomic molecular dynamics simulations of dynein motor domain in explicit water2013

    • Author(s)
      Narutoshi Kamiya, Tadaaki Mashimo, Yu Takano, Takahide Kon, Genji Kurisu, Haruki Nakamura
    • Organizer
      第13回日本蛋白質科学会年会
    • Place of Presentation
      とりぎん文化会館(鳥取県)
    • Related Report
      2013 Annual Research Report
  • [Presentation] GIANT: a database for pattern analysis of protein-small ligand atomic contacts2013

    • Author(s)
      Kota Kasahara, Kengo Kinoshita
    • Organizer
      第13回日本蛋白質科学会年会
    • Place of Presentation
      とりぎん文化会館(鳥取県)
    • Related Report
      2013 Annual Research Report
  • [Presentation] Prediction of Protein-Protein Interactions: Structural Approaches2013

    • Author(s)
      Haruki Nakamura
    • Organizer
      The 2nd HD Physiology International Symposium
    • Place of Presentation
      丸の内MY PLAZAホール(東京都)
    • Related Report
      2013 Annual Research Report
    • Invited
  • [Presentation] The zero-dipole summation method and its application to molecular simulation with homogenous and inhomogeneous systems2013

    • Author(s)
      Ikuo Fukuda, Narutoshi Kamiya, Kota Kasahara, Haruki Nakamura
    • Organizer
      The 12th Asia Pacific Physics Conference (APPC12)
    • Place of Presentation
      幕張メッセ(千葉県)
    • Related Report
      2013 Annual Research Report
  • [Presentation] GIANT: a web-server for analyzing protein-small ligand interactions based on statistically preferred patterns of atomic contacts2013

    • Author(s)
      Kota Kasahara, Kengo Kinoshita
    • Organizer
      ISMB/ECCB 2013
    • Place of Presentation
      ICC Berlin(ドイツ・ベルリン)
    • Related Report
      2013 Annual Research Report
  • [Presentation] All-atom molecular dynamics simulations of dynein motor domain in explicit water2013

    • Author(s)
      Narutoshi Kamiya, Tadaaki Mashimo, Yu Takano, Takahide Kon, Genji Kurisu, Haruki Nakamura
    • Organizer
      Protein Society the 27th Annual Symposium
    • Place of Presentation
      Boston Marriott, Copley Place(米国マサチューセッツ州)
    • Related Report
      2013 Annual Research Report
  • [Presentation] Gene Expression Changes Exposed to 2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD) in Early Developmental Stage Embryos of Red Seabream (Pagrus major)2013

    • Author(s)
      M. Iida, Y. Murakami, Y. Shima, H. Nakamura, Y. Kagami, S. Fujii, A. Srai, H. Iwata
    • Organizer
      転写サイクル合同班会議
    • Place of Presentation
      ホテルおかだ(神奈川県)
    • Related Report
      2013 Annual Research Report
  • [Presentation] ゲノム情報(1D)から蛋白質の動的構造情報(4D)へ2013

    • Author(s)
      中村 春木
    • Organizer
      日本学術会議公開シンポジウム
    • Place of Presentation
      日本学術会議講堂(東京都)
    • Related Report
      2013 Annual Research Report
    • Invited
  • [Presentation] 分子動力学法を用いた転写因子アロステリック制御機構の検討2013

    • Author(s)
      笠原 浩太
    • Organizer
      計算タンパク質科学研究会
    • Place of Presentation
      鳴子観光ホテル(宮城県)
    • Related Report
      2013 Annual Research Report
  • [Presentation] Zero-dipole summation method for evaluating eletrostatic interaction in molecular simulation of biomolecular system2013

    • Author(s)
      Ikuo Fukuda, Narutoshi Kamiya, Haruki Nakamura
    • Organizer
      第51回日本生物物理学会年会
    • Place of Presentation
      国立京都国際会館(京都府)
    • Related Report
      2013 Annual Research Report
  • [Presentation] PDBnet: Integration of Structural and Biochemical Information into Protein Interaction Network2013

    • Author(s)
      Satoshi Fujii, Yuji Kawakami, Satoshi komori, Akinori Sarai
    • Organizer
      第36回日本分子生物学会年会
    • Place of Presentation
      神戸国際会議場(兵庫県)
    • Related Report
      2013 Annual Research Report
  • [Presentation] New approaches to dynamic properties of proteins and their applications to drug discovery of GPCR2013

    • Author(s)
      Haruki Nakamura
    • Organizer
      CADD’13
    • Place of Presentation
      Institut Teknologi Bandung(インドネシア・バンドン)
    • Related Report
      2013 Annual Research Report
    • Invited
  • [Presentation] TCDD曝露したマダイ胚のトランスクリプトーム解析2013

    • Author(s)
      飯田 緑, 藤井 聡, 内田 雅也, 中村 浩, 鏡 良弘, Bak, Su-Min, 金 恩英, 島 康洋, 岩田久人
    • Organizer
      日本内分泌撹乱化学物質学会
    • Place of Presentation
      東京大学(東京都)
    • Related Report
      2013 Annual Research Report
  • [Presentation] Computational protein science: structural bioinformatics and molecular simulations2013

    • Author(s)
      Haruki Nakamura
    • Organizer
      CDAST symposium
    • Place of Presentation
      Jember University(インドネシア・ジャワ)
    • Related Report
      2013 Annual Research Report
    • Invited
  • [Presentation] GAF1, a DELLA interacting protein, regulates gibberellin signaling in Arabidopsis2013

    • Author(s)
      Fukazawa J, Fujiki T, Mori M, Miyamoto C, Kamiya Y, Yamaguchi S, Takahashi Y.
    • Organizer
      21th International Plant Growth Substances Association Conference
    • Place of Presentation
      中国・上海
    • Related Report
      2013 Annual Research Report
  • [Presentation] ジベレリンによる転写制御に関与するGAF1の解析2013

    • Author(s)
      宮本知佳, 深澤壽太郎, 高橋陽介
    • Organizer
      第70回中国四国植物学会
    • Place of Presentation
      徳島大学(徳島県)
    • Related Report
      2013 Annual Research Report
  • [Presentation] DELLA とSCL3 によるGA 生合成酵素遺伝子の転写制御機構の解析2013

    • Author(s)
      寺脇綾香, 伊藤岳, 高橋陽介
    • Organizer
      第70回中国四国植物学会
    • Place of Presentation
      徳島大学(徳島県)
    • Related Report
      2013 Annual Research Report
  • [Presentation] Ca2+を介する新しいGA 信号伝達経路の探索2013

    • Author(s)
      岡田佳那子, 伊藤岳, 高橋陽介
    • Organizer
      第70回中国四国植物学会
    • Place of Presentation
      徳島大学(徳島県)
    • Related Report
      2013 Annual Research Report
  • [Presentation] 植物の新奇転写抑制ドメイン –真核生物に保存された転写抑制機構の解析–2013

    • Author(s)
      伊藤岳, 岡村僚太, 高橋陽介
    • Organizer
      第36回日本分子生物学会
    • Place of Presentation
      神戸国際会議場(兵庫県)
    • Related Report
      2013 Annual Research Report
  • [Presentation] エピジェネティック制御における核内アクチン骨格の関与の解析2012

    • Author(s)
      山崎 祥他
    • Organizer
      第30回染色体ワークショップ・第11回核ダイナミクス研究会
    • Place of Presentation
      淡路夢舞台(兵庫)
    • Year and Date
      2012-12-19
    • Related Report
      2012 Annual Research Report
  • [Presentation] 光で観る計る生体分子のダイナミックな姿2012

    • Author(s)
      徳永 万喜洋
    • Organizer
      東京大学 光量子科学研究センター・レーザーアライアンス合同シンポジウム/第17回 先端光量子科学アライアンスセミナー
    • Place of Presentation
      東京大学(東京)
    • Year and Date
      2012-12-18
    • Related Report
      2012 Annual Research Report
    • Invited
  • [Presentation] ジベレリンによるDELLA-GAF1複合体を介した転写調節制御機構の解析2012

    • Author(s)
      深澤 壽太郎
    • Organizer
      第35回日本分子生物学会年会ワークショップ
    • Place of Presentation
      福岡国際会議場(福岡)
    • Year and Date
      2012-12-12
    • Related Report
      2012 Annual Research Report
    • Invited
  • [Presentation] 神経細胞における生体膜ラフトの動作メカニズムの解明2012

    • Author(s)
      戸田 収
    • Organizer
      第35回 日本分子生物学会年会
    • Place of Presentation
      福岡国際会議場(福岡)
    • Year and Date
      2012-12-12
    • Related Report
      2012 Annual Research Report
  • [Presentation] 3D-RISMを用いた酵素-DNA 複合体中の水和水分布計算2012

    • Author(s)
      入佐正幸
    • Organizer
      第35回溶液化学シンポジウム
    • Place of Presentation
      早稲田大学(東京)
    • Year and Date
      2012-11-12
    • Related Report
      2012 Annual Research Report
  • [Presentation] A simple non-Ewald scheme: the zero-dipole summation method and its application to molecular systems2012

    • Author(s)
      Ikuo Fukuda
    • Organizer
      Conference on Computational Physics (CCP2012)
    • Place of Presentation
      神戸ポートアイランドセンター(兵庫)
    • Year and Date
      2012-10-17
    • Related Report
      2012 Annual Research Report
  • [Presentation] GAF1, A DELLA interacting protein, regulates gibberellin signaling in Arabidops2012

    • Author(s)
      Fukazawa
    • Organizer
      Nature conference “Frontiers in plant biology: From discovery to applications”
    • Place of Presentation
      Ghent, Belgium
    • Year and Date
      2012-10-04
    • Related Report
      2012 Annual Research Report
  • [Presentation] Molecular Dynamics Simulations of Ets1-DNA complexes using Zero-Dipole Summation Method2012

    • Author(s)
      中村 春木
    • Organizer
      第50回日本生物物理学会年会
    • Place of Presentation
      名古屋大学(愛知)
    • Year and Date
      2012-09-24
    • Related Report
      2012 Annual Research Report
  • [Presentation] Spatial-temporal dynamics of calcium signaling and organelles in T cell activation2012

    • Author(s)
      下沢 将啓
    • Organizer
      第50回日本生物物理学会年会
    • Place of Presentation
      名古屋大学(愛知)
    • Year and Date
      2012-09-23
    • Related Report
      2012 Annual Research Report
  • [Presentation] Single molecule analysis of T cell activation with stimulatory lipid bilayers by live cell imaging2012

    • Author(s)
      伊藤 由馬
    • Organizer
      第50回日本生物物理学会年会
    • Place of Presentation
      名古屋大学(愛知)
    • Year and Date
      2012-09-23
    • Related Report
      2012 Annual Research Report
  • [Presentation] Quantitative analysis of changes in molecular dynamics of Arp4 upon transcriptional activation using single-molecule fluorescence imaging2012

    • Author(s)
      一宮 勝雄
    • Organizer
      第50回日本生物物理学会年会
    • Place of Presentation
      名古屋大学(愛知)
    • Year and Date
      2012-09-23
    • Related Report
      2012 Annual Research Report
  • [Presentation] Dynamics of intracellular Ca2+ distribution measured by genetically encoded Ca2+ indicators2012

    • Author(s)
      大山 浩史
    • Organizer
      第50回日本生物物理学会年会
    • Place of Presentation
      名古屋大学(愛知)
    • Year and Date
      2012-09-23
    • Related Report
      2012 Annual Research Report
  • [Presentation] Multifocal plane microscopy for three-dimensional molecular imaging and quantification in living cells2012

    • Author(s)
      稲葉 直道
    • Organizer
      第50回日本生物物理学会年会
    • Place of Presentation
      名古屋大学(愛知)
    • Year and Date
      2012-09-23
    • Related Report
      2012 Annual Research Report
  • [Presentation] Quantitative analysis of single molecule imaging of physicochemical field for genetic activities2012

    • Author(s)
      十川 久美子
    • Organizer
      第50回日本生物物理学会年会シンポジウム
    • Place of Presentation
      名古屋大学(愛知)
    • Year and Date
      2012-09-22
    • Related Report
      2012 Annual Research Report
    • Invited
  • [Presentation] The influence of solvent condition on DNA structures studied by molecular dynamics simulations2012

    • Author(s)
      Satoshi Fujii
    • Organizer
      第50回日本生物物理学会年会
    • Place of Presentation
      名古屋大学(愛知)
    • Year and Date
      2012-09-22
    • Related Report
      2012 Annual Research Report
  • [Presentation] Ion distribution in the EcoRV(restriction enzyme)-DNA complexcalculated by using 3D-RISM2012

    • Author(s)
      Masayuki Irisa
    • Organizer
      Foundations of Molecular Modeling and Simulation
    • Place of Presentation
      Mt. Hood, Oregon, USA
    • Year and Date
      2012-07-22
    • Related Report
      2012 Annual Research Report
  • [Presentation] Dynamics of Spatial-temporal regulation of inflammatory signaling by single molecule analysis2012

    • Author(s)
      Kumiko Sakata
    • Organizer
      Gordon Research Conference Single Molecule Approaches To Biology
    • Place of Presentation
      West Dover, USA
    • Year and Date
      2012-07-18
    • Related Report
      2012 Annual Research Report
  • [Presentation] Quantitative spatiotemoporal dynamics of T cell signaling using single molecule imaging2012

    • Author(s)
      Makio Tokunaga
    • Organizer
      Gordon Research Conference Single Molecule Approaches To Biology
    • Place of Presentation
      West Dover, USA
    • Year and Date
      2012-07-18
    • Related Report
      2012 Annual Research Report
  • [Presentation] Development of stimulatory lipid bilayer system for quantitative analysis of T cell activation by single molecule imaging2012

    • Author(s)
      Yuma Ito
    • Organizer
      Gordon Research Conference Single Molecule Approaches To Biology
    • Place of Presentation
      West Dover, USA
    • Year and Date
      2012-07-18
    • Related Report
      2012 Annual Research Report
  • [Book] 遺伝子発現制御機構 クロマチン,転写制御,エピジェネティクス2017

    • Author(s)
      田村隆明、浦清恵、山口雄輝ほか
    • Total Pages
      264
    • Publisher
      東京化学同人
    • Related Report
      2016 Annual Research Report
  • [Book] 植物生理学概論第二版2017

    • Author(s)
      桜井英博、柴岡弘郎、高橋陽介、小関良宏、藤田知道
    • Publisher
      培風館
    • Related Report
      2016 Annual Research Report
  • [Book] 生命のメカニズム - 美しいイメージで学ぶ構造生命科学入門2015

    • Author(s)
      中村春木(監訳)、工藤高裕、西川建、中村春木(訳)
    • Total Pages
      168
    • Publisher
      シナジー
    • Related Report
      2014 Annual Research Report
  • [Book] 1分子生物学2014

    • Author(s)
      原田 慶恵、石渡 信一、宝谷 紘一、船津 高志、城口 克之、吉田 賢右、上村 想太郎、井出 徹、佐甲 靖志、上田 昌宏、十川 久美子、樋口 秀男、多田隈 尚史、渡邉 朋信、徳永 万喜洋、石島 秋彦、安藤 敏夫、岡田 康志、他
    • Total Pages
      7
    • Publisher
      化学同人
    • Related Report
      2014 Annual Research Report
  • [Book] 見てわかる構造生命科学 - 生命科学研究へのタンパク質構造の利用 -2014

    • Author(s)
      椎名政昭,緒方一博
    • Total Pages
      28
    • Publisher
      化学同人
    • Related Report
      2014 Annual Research Report
  • [Book] 見てわかる構造生命科学 - 生命科学研究へのタンパク質構造の利用 -2014

    • Author(s)
      中村春木(編)、中村春木他9名
    • Total Pages
      326
    • Publisher
      化学同人
    • Related Report
      2014 Annual Research Report
  • [Book] 生命科学から創薬へのイノベーション2014

    • Author(s)
      米田悦啓、堤康央、石井健(編)、中村春木他45名
    • Total Pages
      202
    • Publisher
      南山堂
    • Related Report
      2014 Annual Research Report
  • [Book] 基礎からしっかり学ぶ生化学2014

    • Author(s)
      山口雄輝、成田央
    • Total Pages
      245
    • Publisher
      羊土社
    • Related Report
      2014 Annual Research Report
  • [Book] Fundamentals of Chromatin (Chapter 8 Histone Phosphorylation and Chromatin Dynamics)2014

    • Author(s)
      Mizusaki H, Aihara H, Ito T.
    • Total Pages
      587
    • Publisher
      Springer Science+Business Media New York
    • Related Report
      2013 Annual Research Report
  • [Book] Biomolecular Forms and Functions2013

    • Author(s)
      Eiji Kanamori
    • Total Pages
      502
    • Publisher
      World Scientific Publishing
    • Related Report
      2012 Annual Research Report
  • [Remarks] 新学術領域研究「転写サイクル」ウェブサイト

    • URL

      http://transcriptioncycle.org

    • Related Report
      2016 Annual Research Report
  • [Remarks] 新学術領域研究「転写サイクル」

    • URL

      http://transcriptioncycle.org/

    • Related Report
      2015 Annual Research Report 2014 Annual Research Report
  • [Remarks] 新学術領域「転写サイクル」

    • URL

      http://transcriptioncycle.org

    • Related Report
      2013 Annual Research Report
  • [Remarks] 新学術領域「転写サイクル」

    • URL

      http://transcriptioncycle.org

    • Related Report
      2012 Annual Research Report
  • [Patent(Industrial Property Rights)] 重度の知的障害及び運動発達遅滞を伴う難治性てんかんの検出方法2014

    • Inventor(s)
      松本直通・才津浩智
    • Industrial Property Rights Holder
      横浜市立大学
    • Industrial Property Rights Type
      特許
    • Filing Date
      2014-06-09
    • Related Report
      2014 Annual Research Report
    • Overseas
  • [Patent(Industrial Property Rights)] コフィン-シリス症候群の検出方法2014

    • Inventor(s)
      松本直通・三宅紀子・鶴崎美徳
    • Industrial Property Rights Holder
      横浜市立大学
    • Industrial Property Rights Type
      特許
    • Filing Date
      2014-07-14
    • Related Report
      2014 Annual Research Report
  • [Patent(Industrial Property Rights)] 孔脳症又は脳出血のリスクを予測する方法2014

    • Inventor(s)
      松本直通・才津浩智
    • Industrial Property Rights Holder
      横浜市立大学
    • Industrial Property Rights Type
      特許
    • Filing Date
      2014-05-09
    • Related Report
      2014 Annual Research Report
    • Overseas
  • [Patent(Industrial Property Rights)] Coffin-Siris症候群の新規遺伝子診断法2013

    • Inventor(s)
      鶴崎美徳、松本直通
    • Industrial Property Rights Holder
      鶴崎美徳、松本直通
    • Industrial Property Rights Type
      特許
    • Industrial Property Number
      2013-252720
    • Filing Date
      2013-12-06
    • Related Report
      2013 Annual Research Report

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Published: 2012-11-27   Modified: 2022-02-07  

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