Glial assembly:a new regulatory machinery of brain function and disorders

• Project Area: Glial assembly: a new regulatory machinery of brain function and disorders
• Project/Area Number: 25117001
• Research Category: Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)
• Allocation Type: Single-year Grants
• Review Section: Biological Sciences
• Research Institution: National Institute for Physiological Sciences
• Principal Investigator: Ikenaka Kazuhiro 生理学研究所, 分子細胞生理研究領域, 教授 (00144527)
• Co-Investigator(Kenkyū-buntansha): 小泉 修一 山梨大学, 大学院総合研究部, 教授 (10280752) ; 吉良 潤一 九州大学, 医学研究院, 教授 (40183305) ; 尾崎 紀夫 名古屋大学, 医学系研究科, 教授 (40281480) ; 神庭 重信 九州大学, 医学研究院, 教授 (50195187) ; 竹林 浩秀 新潟大学, 医歯学系, 教授 (60353439) ; 大木 研一 東京大学, 大学院医学系研究科(医学部), 教授 (50332622) ; 植木 孝俊 名古屋市立大学, 大学院医学研究科, 教授 (60317328) ; 山崎 良彦 山形大学, 医学部, 准教授 (10361247) ; 田中 謙二 慶應義塾大学, 医学部, 准教授 (30329700) ; 岡部 繁男 東京大学, 医学(系)研究科(研究院), 教授 (60204012) ; 福山 秀直 京都大学, 医学(系)研究科(研究院), 教授 (90181297)
• Project Period (FY): 2013-06-28 – 2018-03-31
• Project Status: Completed (Fiscal Year 2017)
• Budget Amount: ¥120,380,000 (Direct Cost: ¥92,600,000、Indirect Cost: ¥27,780,000); Fiscal Year 2017: ¥13,650,000 (Direct Cost: ¥10,500,000、Indirect Cost: ¥3,150,000); Fiscal Year 2016: ¥11,180,000 (Direct Cost: ¥8,600,000、Indirect Cost: ¥2,580,000); Fiscal Year 2015: ¥13,650,000 (Direct Cost: ¥10,500,000、Indirect Cost: ¥3,150,000); Fiscal Year 2014: ¥11,180,000 (Direct Cost: ¥8,600,000、Indirect Cost: ¥2,580,000); Fiscal Year 2013: ¥70,720,000 (Direct Cost: ¥54,400,000、Indirect Cost: ¥16,320,000)
• Keywords: グリア / 精神・神経疾患 / 神経興奮制御 / 精神疾患 / 活動電位の伝達速度 / 活動電位の伝導速度

Outline of Final Research Achievements

Managing Committee of Scientific Research on Innovative Area “Glial Assembly” aimed to open our achievement to the public. For this purpose we organized Open Symposia for 5 times (two of which were international symposia). Also we participated and organized two symposia in Comprehensive Brain Science Network together with other Scientific Research on Innovative Area. Through these activities we succeeded in making the concept “Glial Assembly” popular in the neuroscience community.

Research Products

• [Int'l Joint Research] University of Saarland/University of Duesseldorf/MaxDelbruckCenterforMolecularMedicine(ドイツ)
• [Journal Article] Connexins in health and disease. (2018)
  • Author(s): Yamasaki R
  • Journal Title: Clin Exp Neuroimmunol Volume: 9 Issue: S1 Pages: 30-36
  • DOI: 10.1111/cen3.12433
  • Peer Reviewed / Open Access
• [Journal Article] Novel disease-modifying anti-rheumatic drug iguratimod suppresses chronic experimental autoimmune encephalomyelitis by down-regulating activation of macrophages/microglia through an NF-κB pathway (2018)
  • Author(s): Guangrui Li, Ryo Yamasaki, Mei Fang, Katsuhisa Masaki, Hirofumi Ochi, Takuya Matsushita, Jun-ichi Kira
  • Journal Title: SCIENTIFIC REPORTS Volume: 8 Issue: 1 Pages: 1933-1933
  • DOI: 10.1038/s41598-018-20390-5
  • Peer Reviewed / Open Access
• [Journal Article] Early strong intrathecal inflammation in cerebellar type multiple system atrophy by cerebrospinal fluid cytokine/chemokine profiles: a case control study. (2017)
  • Author(s): Yamasaki R, Yamaguchi H, Matsushita T, Fujii T, Hiwatashi A, *Kira JI.
  • Journal Title: J Neuroinflammation Volume: 14 Issue: 1 Pages: 89-89
  • DOI: 10.1186/s12974-017-0863-0
  • Peer Reviewed / Open Access
• [Journal Article] Dysregulated gene expressions of MEX3D, FOS and BCL2 in human induced-neuronal (iN) cells from NF1 patients: a pilot study (2017)
  • Author(s): Sagata N, Kato TA, Kano SI, Ohgidani M, Shimokawa N, Sato-Kasai M, Hayakawa K, Kuwano N, Wilson AM, Ishizuka K, Kato S, Nakahara T, Nakahara-Kido M, Setoyama D, Sakai Y, Ohga S, Furue M, Sawa A, Kanba S.
  • Journal Title: Sci Rep. Volume: 7 Issue: 1 Pages: 13905-13905
  • DOI: 10.1038/s41598-017-14440-7
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Fibromyalgia and microglial TNF-α: Translational research using human blood induced microglia-like cells (2017)
  • Author(s): Ohgidani Masahiro、Kato Takahiro A.、Hosoi Masako、Tsuda Makoto、Hayakawa Kohei、Hayaki Chie、Iwaki Rie、Sagata Noriaki、Hashimoto Ryota、Inoue Kazuhide、Sudo Nobuyuki、Kanba Shigenobu
  • Journal Title: Scientific Reports Volume: 7 Issue: 1 Pages: 1-6
  • DOI: 10.1038/s41598-017-11506-4
  • Peer Reviewed / Open Access
• [Journal Article] Microglial CD206 gene has potential as a state marker of bipolar disorder (2017)
  • Author(s): 1.Ohgidani M, Kato TA, Haraguchi Y, Matsushima T, Mizoguchi Y, Murakawa-Hirachi T, Sagata N, Monji A, Kanba S.
  • Journal Title: Frontiers in Immunology Volume: 7 Pages: 676-676
  • DOI: 10.3389/fimmu.2016.00676
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Rabies virus-mediated oligodendrocyte labeling reveals a single oligodendrocyte myelinates axons from distinct brain regions (2017)
  • Author(s): Osanai Y, Shimizu T, Mori T, Yoshimura Y, Hatanaka N, Nambu A, Kimori Y, Koyama S, Kobayashi K, Ikenaka K.
  • Journal Title: Glia Volume: 65 Issue: 1 Pages: 93-105
  • DOI: 10.1002/glia.23076
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] High-resolution copy number variation analysis of schizophrenia in Japan. (2017)
  • Author(s): Kushima I, Aleksic B, Nakatochi M, Shimamura T, Shiino T, Yoshimi A, Kimura H, Takasaki Y, Wang C, Xing J, Ishizuka K, Oya-Ito T, Nakamura Y, Arioka Y, Maeda T, Yamamoto M, Yoshida M, Noma H, Hamada S, Morikawa M, Uno Y, Okada T, Iidaka T, Iritani S, Yamamoto T,
  • Journal Title: Molecular Psychiatry Volume: 22 Issue: 3 Pages: 430-440
  • DOI: 10.1038/mp.2016.88
  • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
• [Journal Article] Characteristic microglial features in patients with hereditary diffuse leukoencephalopathy with spheroids (2016)
  • Author(s): Tada M，Konno T，Tada M, Tezuka T, Okazaki K, Arakawa M，Itoh K，Yamamoto T, Yokoo H, Yoshikura N，Ishihara K, Horie M, Takebayashi H, Toyoshima Y, Naito M, Onodera O, Nishizawa M, Takahashi H, Ikeuchi T，Kakita A
  • Journal Title: Annals of Neurology Volume: 80 Issue: 4 Pages: 554-565
  • DOI: 10.1002/ana.24754
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] Allergic inflammation leads to neuropathic pain via glial cell activation (2016)
  • Author(s): Yamasaki R, Fujii T, Qang B, Masaki K, A Kido M, Yoshida M, Matsushita T, Kira JI.
  • Journal Title: The journal of neuroscience Volume: 36(47) Issue: 47 Pages: 11929-11945
  • DOI: 10.1523/jneurosci.1981-16.2016
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Resequencing and Association Analysis of Six PSD-95-Related Genes as Possible Susceptibility Genes for Schizophrenia and Autism Spectrum Disorders (2016)
  • Author(s): Xing J, Kimura H, Wang C, Ishizuka K, Kushima I, Arioka Y, Yoshimi A, Nakamura Y, Shiino T, Oya-Ito T, Takasaki Y, Uno Y, Okada T, Iidaka T, Aleksic B, Mori D, Ozaki N.
  • Journal Title: Scientific Reports Volume: 6 Issue: 1 Pages: 27491-27491
  • DOI: 10.1038/srep27491
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Th1 cells downregulate connexin 43 gap junctions in astrocytes via microglial activation (2016)
  • Author(s): Watanabe M, Masaki K, Yamasaki R, Kawanokuchi J, Takeuchi H, Matsushita T, Suzumura A, Kira JI.
  • Journal Title: Scientific Reports Volume: 6 Issue: 1 Pages: 38387-38387
  • DOI: 10.1038/srep38387
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Mutation screening of GRIN2B in schizophrenia and autism spectrum disorder in a Japanese population. (2016)
  • Author(s): Takasaki Y, Koide T, Wang C, Kimura H, Xing J, Kushima I, Ishizuka K, Mori D, Sekiguchi M, Ikeda M, Aizawa M, Tsurumaru N, Iwayama Y, Yoshimi A, Arioka Y, Yoshida M, Noma H, Oya-Ito T, Nakamura Y, Kunimoto S, Aleksic B, Uno Y, Okada T, Ujike H, Egawa J, Kuwabara H, Someya T, Yoshikawa T, Iwata N, Ozaki N
  • Journal Title: Scientific Reports Volume: 6 Issue: 1 Pages: 33311-33311
  • DOI: 10.1038/srep33311
  • Peer Reviewed / Open Access
• [Journal Article] Aripiprazole inhibits polyI:C-induced microglial activation possibly via TRPM7 (2016)
  • Author(s): Sato-Kasai M, Kato TA, Ohgidani M, Mizoguchi Y, Sagata N, Inamine S, Horikawa H, Hayakawa K, Shimokawa N, Kyuragi S, Seki Y, Monji A, Kanba S.
  • Journal Title: Schizophrenia Research Volume: 178(1-3) Issue: 1-3 Pages: 35-43
  • DOI: 10.1016/j.schres.2016.08.022
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] Identification of a rare variant in CHD8 that contributes to schizophrenia and autism spectrum disorder susceptibility (2016)
  • Author(s): Kimura H, Wang C, Ishizuka K, Xing J, Takasaki Y, Kushima I, Aleksic B, Uno Y, Okada T, Ikeda M, Mori D, Inada T, Iwata N, Ozaki N.
  • Journal Title: Schizophr Res Volume: 178 Issue: 1-3 Pages: 104-106
  • DOI: 10.1016/j.schres.2016.08.023
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Investigation of Rare Single-Nucleotide PCDH15 Variants in Schizophrenia and Autism Spectrum Disorders (2016)
  • Author(s): Ishizuka, K., H. Kimura, C. Wang, J. Xing, I. Kushima, Y. Arioka, T. Oya-Ito, Y. Uno, T. Okada, D. Mori, B. Aleksic, and N. Ozaki.
  • Journal Title: PLoS One Volume: 11 Issue: 4 Pages: e0153224-e0153224
  • DOI: 10.1371/journal.pone.0153224
  • Peer Reviewed / Open Access
• [Journal Article] Plasma Metabolites Predict Severity of Depression and Suicidal Ideation in Psychiatric Patients-A Multicenter Pilot Analysis (2016)
  • Author(s): Setoyama D, Kato TA, Hashimoto R, Kunugi H, Hattori K, Hayakawa K, Sato-Kasai M, Shimokawa N, Kaneko S, Yoshida S, Goto YI, Yasuda Y, Yamamori H, Ohgidani M, Sagata N, Miura D, Kang D, Kanba S
  • Journal Title: PLoS ONE Volume: 11(12) Issue: 12 Pages: e0165267-e0165267
  • DOI: 10.1371/journal.pone.0165267
  • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
• [Journal Article] TNF-α from hippocampal microglia directly induces working memory deficits by acute stress in mice. (2016)
  • Author(s): Ohgidani M, Kato TA*, Sagata N, Hayakawa K, Shimokawa N, Sato-Kasai M, Kanba S
  • Journal Title: Brain, Behavior, and Immunity Volume: in press Pages: 17-24
  • DOI: 10.1016/j.bbi.2015.08.022
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] Early and Extensive Spinal White Matter Involvement in Neuromyelitis Optica. (2015)
  • Author(s): Hayashida S, et al
  • Journal Title: Brain Pathol Volume: in press Issue: 3 Pages: 249-265
  • DOI: 10.1111/bpa.12386
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] Introducing directly induced microglia-like (iMG) cells from fresh human monocytes: A novel translational research tool for psychiatric disorders (2015)
  • Author(s): Ohgidani M, Kato TA*, Kanba S.
  • Journal Title: Frontiers in Cellular Neuroscience Volume: in press Pages: 184-184
  • DOI: 10.3389/fncel.2015.00184
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] White matter microstructure between the pre-SMA and the cingulum bundle is related to response conflict in healthy subjects. (2015)
  • Author(s): Yamamoto M, Kushima I, Kimura H, Hayashi A, Kawano N, Aleksic B, Iidaka T, Ozaki N
  • Journal Title: Brain Behav Volume: 5 Issue: 10
  • DOI: 10.1002/brb3.375
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Glia-related genes and their contribution to schizophrenia. (2015)
  • Author(s): Wang C, Aleksic B, Ozaki N
  • Journal Title: Psychiatry Clin Neurosci Volume: in press Issue: 8 Pages: 448-461
  • DOI: 10.1111/pcn.12290
  • Peer Reviewed / Open Access
• [Journal Article] Identification of Rare, Single-Nucleotide Mutations in NDE1 and Their Contributions to Schizophrenia Susceptibility. (2015)
  • Author(s): Kimura H, Tsuboi D, Wang C, Kushima I, Koide T, Ikeda M, Iwayama Y, Toyota T, Yamamoto N, Kunimoto S, Nakamura Y, Yoshimi A, Banno M, Xing J, Takasaki Y, Yoshida M, Aleksic B, Uno Y, Okada T, Iidaka T, Inada T, Suzuki M, Ujike H, Kunugi H, Kato T, Yoshikawa T, Iwata N, Kaibuchi K
  • Journal Title: Schizophrenia Bulltein Volume: 41 Issue: 3 Pages: 744-753
  • DOI: 10.1093/schbul/sbu147
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Association study of BCL9 gene polymorphism rs583583 with schizophrenia and negative symptoms in Japanese population. (2015)
  • Author(s): Kimura H, Tanaka S, Kushima I, Koide T, Banno M, Kikuchi T, Nakamura Y, Shiino T, Yoshimi A, Oya-Ito T, Xing J, Wang C, Takasaki Y, Aleksic B, Okada T, Ikeda M, Inada T, Iidaka T, Iwata N, Ozaki N.
  • Journal Title: Scientific reports Volume: 5 Issue: 1 Pages: 15705-15705
  • DOI: 10.1038/srep15705
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] ストレスとミクログリア―トランスレーショナル研究― (2015)
  • Author(s): 加藤隆弘, 扇谷昌宏, 早川宏平, 渡部幹, 神庭重信
  • Journal Title: ストレス科学 Volume: 29(4) Pages: 373-388
  • Acknowledgement Compliant
• [Journal Article] 精神疾患患者のミクログリア活性化特性と精神病理現象との相関を解明するためのトランスレーショナル研究 (2015)
  • Author(s): 加藤隆弘, 扇谷昌宏, 渡部幹, 神庭重信
  • Journal Title: 日本生物学的精神医学会誌（旧：脳と精神の科学） Volume: 26(3) Pages: 140-145
  • NAID: 130005395599
  • Acknowledgement Compliant
• [Journal Article] 免疫と統合失調症―ミクログリア仮説― (2015)
  • Author(s): 加藤隆弘, 神庭重信
  • Journal Title: 精神科 Volume: 27(4) Pages: 228-233
  • Acknowledgement Compliant
• [Journal Article] 精神疾患のミクログリア仮説解明のための橋渡し研究 (2015)
  • Author(s): 加藤隆弘, 扇谷昌宏, 神庭重信
  • Journal Title: 生命の科学 Volume: 66(6) Pages: 584-588
  • Acknowledgement Compliant
• [Journal Article] Resequencing and Association Analysis of PTPRA, a Possible Susceptibility Gene for Schizophrenia and Autism Spectrum Disorders (2014)
  • Author(s): Xing J, Wang C, Kimura H, Takasaki Y, Kunimoto S, Yoshimi A, Nakamura Y, Koide T, Banno M, Kushima I, Uno Y, Okada T, Aleksic B, Ikeda M, Iwata N, Ozaki N.
  • Journal Title: PLoS One Volume: 9 Issue: 1-3 Pages: 149-156
  • DOI: 10.1016/j.schres.2014.04.032
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Direct induction of ramified microglia-like cells from human monocytes: Dynamic microglial dysfunction in Nasu-Hakola disease. (2014)
  • Author(s): Ohgidani M, Kato TA*, Setoyama D, Sagata N, Hashimoto R, Shigenobu K, Yoshida T, Hayakawa K, Shimokawa N, Miura D, Utsumi H, Kanba S
  • Journal Title: Scientific Reports Volume: 4 Issue: 1 Pages: 4957-4957
  • DOI: 10.1038/srep04957
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Presentation] グリア細胞によるシナプス制御；液性と接触性因子 (2015)
  • Author(s): 小泉修一
  • Organizer: 第13回糖鎖科学コンソーシアムシンポジウム
  • Place of Presentation: 愛知県産業労働センター「ウインクあいち」愛知県名古屋市
  • Year and Date: 2015-10-20
  • Invited
• [Presentation] How does an oligodendrocyte select axons to myelinate? (2015)
  • Author(s): 池中一裕
  • Organizer: XII European Meeting on Glial Cells in Health and Disease
  • Place of Presentation: Bilbao, Spain
  • Year and Date: 2015-07-15
  • Int'l Joint Research / Invited
• [Presentation] In vivo imaging of glial Ca2＋ dynamics using an ultrasensitive Ca2＋ indicator (2015)
  • Author(s): 飯野正光
  • Organizer: XII European Meeting on Glial Cells in Health and Disease
  • Place of Presentation: Bilbao, Spain
  • Year and Date: 2015-07-15
  • Int'l Joint Research / Invited
• [Presentation] KENGE-tet system: promising strategy to achieve sufficient probe expression in glial cells (2015)
  • Author(s): 田中謙二
  • Organizer: XII European Meeting on Glial Cells in Health and Disease
  • Place of Presentation: Bilbao, Spain
  • Year and Date: 2015-07-15
  • Int'l Joint Research / Invited
• [Presentation] Imaging microglia and synapses with an optical clearing technique (2015)
  • Author(s): 岡部繁男
  • Organizer: XII European Meeting on Glial Cells in Health and Disease
  • Place of Presentation: Bilbao, Spain
  • Year and Date: 2015-07-15
  • Int'l Joint Research / Invited
• [Presentation] グリアアセンブリの破綻からみた神経疾患 (2014)
  • Author(s): 吉良潤一
  • Organizer: 包括脳シンポジウム 新学術領域研究「精神神経疾患研究の現状と展望：新学術5領域の相互理解・連携を目指して」
  • Place of Presentation: 東京医科歯科大学 鈴木章夫記念講堂（東京都文京区）
  • Year and Date: 2014-12-11
• [Presentation] グリアアセンブリの破綻としての精神疾患を特定する (2014)
  • Author(s): 尾崎紀夫
  • Organizer: 包括脳シンポジウム 新学術領域研究「精神神経疾患研究の現状と展望：新学術5領域の相互理解・連携を目指して」
  • Place of Presentation: 東京医科歯科大学 鈴木章夫記念講堂（東京都文京区）
  • Year and Date: 2014-12-11
• [Remarks] グリアアセンブリによる脳機能発現の制御と病態
  • URL: http://square.umin.ac.jp/glialassembl/
• [Remarks] Young Glia (国際グリア研究ネットワーク構築プロジェクト)
  • URL: http://www.ims.med.tohoku.ac.jp/youngglia/index.html
• [Patent(Industrial Property Rights)] MARKER FOR NEUROPATHIC PAIN AND USE THEREOF (2018)
  • Inventor(s): 藤井敬之、山﨑亮、飯沼今日子、吉良潤一、他2名
  • Industrial Property Rights Holder: 九州大学
  • Industrial Property Rights Type: 特許
  • Filing Date: 2018
  • Overseas