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Brain Protein Aging and Dementia Control

Administrative Group

Project AreaPrevention of brain protein aging and dementia
Project/Area Number 26117001
Research Category

Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)

Allocation TypeSingle-year Grants
Review Section Biological Sciences
Research InstitutionNagoya University

Principal Investigator

Sobue Gen  名古屋大学, 医学系研究科, 特任教授 (20148315)

Research Collaborator WATANABE hirohisa  
Project Period (FY) 2014-07-10 – 2019-03-31
Project Status Completed (Fiscal Year 2018)
Budget Amount *help
¥157,820,000 (Direct Cost: ¥121,400,000、Indirect Cost: ¥36,420,000)
Fiscal Year 2018: ¥29,510,000 (Direct Cost: ¥22,700,000、Indirect Cost: ¥6,810,000)
Fiscal Year 2017: ¥29,380,000 (Direct Cost: ¥22,600,000、Indirect Cost: ¥6,780,000)
Fiscal Year 2016: ¥32,760,000 (Direct Cost: ¥25,200,000、Indirect Cost: ¥7,560,000)
Fiscal Year 2015: ¥32,630,000 (Direct Cost: ¥25,100,000、Indirect Cost: ¥7,530,000)
Fiscal Year 2014: ¥33,540,000 (Direct Cost: ¥25,800,000、Indirect Cost: ¥7,740,000)
Keywords蛋白質 / 痴呆 / 脳・神経 / 老化 / 神経科学 / 神経変性疾患 / タウ / 脳タンパク質 / 認知症
Outline of Final Research Achievements

Our general manager section coordinated the progress of the whole area and formulated the activity policy. The section made support and evaluation and advice on individual research activities while promoting exchange and cooperation among members necessary for achieving the purpose. We effectively promoted the exchange of information and joint research within our group and developed an external public relations activity of domain research including the promotion of internationalization and outreach activity. Specifically, we held a total of nine members' meetings and four retreats. Information and our activity were regularly sent on the website to support various domestic symposia. We held summer school and winter school for young researchers three to six times a year, and also held educational activities for high school students, and held one to two public lectures once a year. We proceeded with the management and transportation of PET probes.

Academic Significance and Societal Importance of the Research Achievements

総括班は、新学術領域研究(研究領域提案型)「脳タンパク質老化と認知症制御」に参画した国内外の多くの研究者が円滑に研究を推進しできるように包括的な支援をするとともに、若手の教育機会の提供や、市民へのアウトリーチ活動などを精力的に行った。結果として、別の報告書にあるように、当領域からの多くの国際的研究成果発信に繋がるとともに、今後の発展的な連携へ向けた多くの協力研究体制基盤や、大規模イメージング・ゲノム・オミックスコホートが構築された。これらは、将来的な認知症の克服に繋がると期待され、その社会的意義は極めて大きい。さらに、成果の社会・国民への発信も強力にサポートした。

Report

(6 results)
  • 2018 Annual Research Report   Final Research Report ( PDF )
  • 2017 Annual Research Report
  • 2016 Annual Research Report
  • 2015 Annual Research Report
  • 2014 Annual Research Report
  • Research Products

    (135 results)

All 2019 2018 2017 2016 2015 2014 Other

All Int'l Joint Research (7 results) Journal Article (52 results) (of which Int'l Joint Research: 5 results,  Peer Reviewed: 52 results,  Open Access: 28 results,  Acknowledgement Compliant: 9 results) Presentation (61 results) (of which Int'l Joint Research: 23 results,  Invited: 22 results) Book (4 results) Remarks (2 results) Patent(Industrial Property Rights) (4 results) (of which Overseas: 2 results) Funded Workshop (5 results)

  • [Int'l Joint Research] ペトロナス工科大学(マレーシア)

    • Related Report
      2018 Annual Research Report
  • [Int'l Joint Research] ピッツバーグ大学(米国)

    • Related Report
      2017 Annual Research Report
  • [Int'l Joint Research] ノッティンガム大学(英国)

    • Related Report
      2017 Annual Research Report
  • [Int'l Joint Research] 香港中文大学(中国)

    • Related Report
      2017 Annual Research Report
  • [Int'l Joint Research] ペトロナス工科大学(マレーシア)

    • Related Report
      2017 Annual Research Report
  • [Int'l Joint Research] University of Pittsburgh(米国)

    • Related Report
      2016 Annual Research Report
  • [Int'l Joint Research] University of Laval(シンガポール)

    • Related Report
      2016 Annual Research Report
  • [Journal Article] Brain Protein Aging and Dementia Control2019

    • Author(s)
      G Sobue G,N Sahara.
    • Journal Title

      Frontiers

      Volume: -

    • DOI

      10.3389/fnins.2019.00029

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Effects of Gradient Coil Noise and Gradient Coil Replacement on the Reproducibility of Resting State Networks2018

    • Author(s)
      Bagarinao Epifanio、Tsuzuki Erina、Yoshida Yukina、Ozawa Yohei、Kuzuya Maki、Otani Takashi、Koyama Shuji、Isoda Haruo、Watanabe Hirohisa、Maesawa Satoshi、Naganawa Shinji、Sobue Gen
    • Journal Title

      Frontiers in Human Neuroscience

      Volume: 12 Pages: 148-148

    • DOI

      10.3389/fnhum.2018.00148

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Silencing of FUS in the common marmoset (Callithrix jacchus) brainvia stereotaxic injection of an adeno-associated virus encoding shRNA.2018

    • Author(s)
      Endo K, Ishigaki S, Masamizu Y, Fujioka Y, Watakabe A, Yamamori T, Hatanaka N, Nambu A, Okado H, Katsuno M, Watanabe H, Matsuzaki M, Sobue G
    • Journal Title

      Neurosci Res

      Volume: in press Pages: 30183-9

    • DOI

      10.1016/j.neures.2017.08.006

    • Related Report
      2018 Annual Research Report 2017 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Modeling sporadic ALS in iPSC-derived motor neurons identifies a potential therapeutic agent.2018

    • Author(s)
      Fujimori K, Ishikawa M, Otomo A, Atsuta N, Nakamura R, Akiyama T, Hadano S, Aoki M, Saya H, Sobue G, Okano H.
    • Journal Title

      Nat Med.

      Volume: 24 Issue: 10 Pages: 1579-1589

    • DOI

      10.1038/s41591-018-0140-5

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Corpus callosal involvement is correlated with cognitive impairment in multiple system atrophy.2018

    • Author(s)
      Hara K, Watanabe H, Bagarinao E, Kawabata K, Yoneyama N, Ohdake R, Imai K, Masuda M, Yokoi T, Ogura A, Tsuboi T, Ito M, Atsuta N, Niwa H, Taoka T, Maesawa S, Naganawa S, Katsuno M, Sobue G.
    • Journal Title

      J Neurol.

      Volume: 265 Issue: 9 Pages: 2079-2087

    • DOI

      10.1007/s00415-018-8923-7

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Importance of Functional Loss of FUS in FTLD/ALS2018

    • Author(s)
      Ishigaki Shinsuke、Sobue Gen
    • Journal Title

      Frontiers in Molecular Biosciences

      Volume: 5 Pages: 44-44

    • DOI

      10.3389/fmolb.2018.00044

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Distinct manifestation of cognitive deficits associate with different resting-state network disruptions in non-demented patients with Parkinson's disease.2018

    • Author(s)
      Kawabata K
    • Journal Title

      J Neurol.

      Volume: 265(3) Issue: 3 Pages: 688-700

    • DOI

      10.1007/s00415-018-8755-5

    • Related Report
      2018 Annual Research Report 2017 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Age-related impairment in Addenbrooke's cognitive examination revised scores in patients with amyotrophic lateral sclerosis.2018

    • Author(s)
      Masuda M, Watanabe H, Tanaka Y, Ohdake R, Ogura A, Yokoi T, Imai K, Kawabata K, Riku Y, Hara K, Nakamura R, Atsuta N, Katsuno M, Sobue G.
    • Journal Title

      Amyotroph Lateral Scler Frontotemporal Degener.

      Volume: Epub ahead of print Issue: 7-8 Pages: 1-7

    • DOI

      10.1080/21678421.2018.1510009

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Pathogenesis of Frontotemporal Lobar Degeneration: Insights From Loss of Function Theory and Early Involvement of the Caudate Nucleus2018

    • Author(s)
      Sobue Gen、Ishigaki Shinsuke、Watanabe Hirohisa
    • Journal Title

      Frontiers in Neuroscience

      Volume: 12 Pages: 473-473

    • DOI

      10.3389/fnins.2018.00473

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Frequency and characteristics of the TBK1 gene variants in Japanese patients with sporadic amyotrophic lateral sclerosis2018

    • Author(s)
      Tohnai Genki、Nakamura Ryoichi、Sone Jun、Nakatochi Masahiro、Yokoi Daichi、Katsuno Masahisa、Watanabe Hazuki、Watanabe Hirohisa、Ito Mizuki、Li Yuanzhe、Izumi Yuishin、et al. Atsuta Naoki、Sobue Gen
    • Journal Title

      Neurobiology of Aging

      Volume: 64 Pages: 158.e15-158.e19

    • DOI

      10.1016/j.neurobiolaging.2017.12.005

    • Related Report
      2018 Annual Research Report 2017 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Clinical and Imaging Features of Multiple System Atrophy: Challenges for an Early and Clinically Definitive Diagnosis.2018

    • Author(s)
      H Watanabe, Y. Riku, K Hara, K Kawabata, T Nakamura, M Ito, M Hirayama, M Yoshida, M Katsuno, G Sobue.
    • Journal Title

      J Mov Disord

      Volume: 11 (No3) Issue: 3 Pages: 107-120

    • DOI

      10.14802/jmd.18020

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Involvement of the Precuneus/Posterior Cingulate Cortex Is Significant for the Development of Alzheimer’s Disease: A PET (THK5351, PiB) and Resting fMRI Study2018

    • Author(s)
      Yokoi Takamasa、Watanabe Hirohisa、Ishigaki Shinsuke、Katsuno Masahisa、Miyao Shinichi、Kato Katsuhiko、Naganawa Shinji、Harada Ryuichi、Okamura Nobuyuki、Yanai Kazuhiko、Yoshida Mari、Sobue Gen (ほか9名)
    • Journal Title

      Frontiers in Aging Neuroscience

      Volume: 10 Pages: 304-304

    • DOI

      10.3389/fnagi.2018.00304

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Severe hyposmia and aberrant functional connectivity in cognitively normal Parkinson's disease.2018

    • Author(s)
      Yoneyama N
    • Journal Title

      PLoS One.

      Volume: 13(1) Issue: 1 Pages: e0190072-e0190072

    • DOI

      10.1371/journal.pone.0190072

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] An unbiased data-driven age-related structural brain parcellation for the identification of intrinsic brain volume changes over the adult lifespan.2018

    • Author(s)
      Bagarinao E
    • Journal Title

      Neuroimage.

      Volume: 169 Pages: 134-144

    • DOI

      10.1016/j.neuroimage.2017.12.014

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Altered GluA1 (Gria1) Function and Accumbal Synaptic Plasticity in the ClockΔ19 Model of Bipolar Mania.2017

    • Author(s)
      Parekh PK, Becker-Krail D, Sundaravelu P, Ishigaki S, Okado H, Sobue G, Huang Y, McClung CA.
    • Journal Title

      Biol Psychiatry

      Volume: S0006 Issue: 11 Pages: 31721-3

    • DOI

      10.1016/j.biopsych.2017.06.022

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] 3'UTR Length-Dependent Control of SynGAP Isoform α2 mRNA by FUS and ELAV-like Proteins Promotes Dendritic Spine Maturation and Cognitive Function.2017

    • Author(s)
      Yokoi S, Udagawa T, Fujioka Y, Honda D, Okado H, Watanabe H, Katsuno M.
    • Journal Title

      Cell Rep

      Volume: 20(13) Issue: 13 Pages: 3071-3084

    • DOI

      10.1016/j.celrep.2017.08.100

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Non-motor multiple system atrophy associated with sudden death: pathological observations of autonomic nuclei.2017

    • Author(s)
      Riku Y, Watanabe H, Mimuro M, Iwasaki Y, Ito M, Katsuno M, Sobue G, Yoshida M.
    • Journal Title

      J Neurol

      Volume: 264(11) Issue: 11 Pages: 2249-2257

    • DOI

      10.1007/s00415-017-8604-y

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Pathologic Involvement of Glutamatergic Striatal Inputs From the Cortices in TAR DNA-Binding Protein 43kDa-Related Frontotemporal Lobar Degeneration and Amyotrophic Lateral Sclerosis.2017

    • Author(s)
      Riku Y, Watanabe H, Yoshida M, Mimuro M, Iwasaki Y, Masuda M, Ishigaki S.
    • Journal Title

      J Neuropathol Exp Neurol

      Volume: 76(9) Issue: 9 Pages: 759-768

    • DOI

      10.1093/jnen/nlx055

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Structural MRI correlates of amyotrophic lateral sclerosis progression2017

    • Author(s)
      Senda Joe、Atsuta Naoki、Watanabe Hirohisa、Bagarinao Epifanio、Imai Kazunori、Yokoi Daichi、Riku Yuichi、Masuda Michihito、Nakamura Ryoichi、Watanabe Hazuki、Ito Mizuki、Katsuno Masahisa、Naganawa Shinji、Sobue Gen
    • Journal Title

      Journal of Neurology, Neurosurgery & Psychiatry

      Volume: 88 Issue: 11 Pages: 901-907

    • DOI

      10.1136/jnnp-2016-314337

    • NAID

      120006375888

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Altered tau isoform ratio caused by loss of Fus and Sfpq function leads to FTLD-like phenotypes2017

    • Author(s)
      Ishigaki S, Fujioka Y, Okada Y, Riku Y, Udagawa T, Honda D, Yokoi S, Endo K, Ikenaka K, Takagi S, Iguchi Y, Sahara N, Takashima A, Okano H, Yoshida M, Warita H, Aoki M, Watanabe H, Okado H, Katsuno H, Sobue G.
    • Journal Title

      Cell Reports

      Volume: 18 Issue: 5 Pages: 1118-1131

    • DOI

      10.1016/j.celrep.2017.01.013

    • Related Report
      2017 Annual Research Report 2016 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Marked Involvement of the Striatal Efferent System in TAR DNA-Binding Protein 43 kDa-Related Frontotemporal Lobar Degeneration and Amyotrophic Lateral Sclerosis.2017

    • Author(s)
      Riku Y., Watanabe H., Yoshida M., Mimuro M., Iwasaki Y., Masuda M., Ishigaki S., Katsuno M., Sobue G.
    • Journal Title

      J Neuropathol Exp Neurol

      Volume: in press Issue: 8 Pages: 801-811

    • DOI

      10.1093/jnen/nlw053

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Gene Expression Profile of Inflammatory Myopathy with Malignancy is Similar to that of Dermatomyositis rather than Polymyositis2016

    • Author(s)
      Noda, T., Iijima, M., Noda, S., Maeshima, S., Nakanishi, H., Kimura, S., Koike, H., Ishigaki, S., Iguchi, Y., Katsuno, M., and Sobue, G.
    • Journal Title

      Internal Medicine

      Volume: 55 Issue: 18 Pages: 2571-2580

    • DOI

      10.2169/internalmedicine.55.6706

    • NAID

      130005414859

    • ISSN
      0918-2918, 1349-7235
    • Related Report
      2016 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Involvement of the caudate nucleus head and its networks in sporadic amyotrophic lateral sclerosis-frontotemporal dementia continuum.2016

    • Author(s)
      Masuda, M., Senda, J., Watanabe, H., Epifanio, B., Tanaka, Y., Imai, K., Riku, Y., Li, Y., Nakamura, R., Ito, M., Ishigaki, S., Atsuta, N., Koike, H., Katsuno, M., Hattori, N., Naganawa, S., and Sobue, G.
    • Journal Title

      Amyotroph Lateral Scler Frontotemporal Degener

      Volume: 17 Issue: 7-8 Pages: 571-579

    • DOI

      10.1080/21678421.2016.1211151

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Clinicopathological features of adult-onset neuronal intranuclear inclusion disease.2016

    • Author(s)
      Sone J., Nakamura T., Koike H., Takashima H., Hashiguchi A., Kohno Y., Kurashige T., Kuriyama M., Takiyama Y., Tsuchiya M., Kitagawa N., Kawamoto M., Yoshimura H., Suto Y., Nakayasu H., Uehara N., Sugiyama H., Takahashi M., Kokubun N., Konno T., Katsuno M., Tanaka F., Iwasaki Y., Yoshida M., Sobue G., et al
    • Journal Title

      Brain

      Volume: 139 Issue: 12 Pages: 3170-3186

    • DOI

      10.1093/brain/aww249

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Exosome secretion is a key pathway for clearance of pathological TDP-43.2016

    • Author(s)
      Iguchi Y,, Eid L,, Parent M,, Soucy G,, Bareil C,, Riku Y,, Kawai K,, Takagi S,, Yoshida M,, Katsuno M,, Sobue G., Julien JP.
    • Journal Title

      Brain

      Volume: 139 Issue: 12 Pages: 3187-3201

    • DOI

      10.1093/brain/aww237

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Impaired muscle uptake of creatine in spinal and bulbar muscular atrophy.2016

    • Author(s)
      Hijikata Y., Katsuno M., Suzuki K., Hashizume A., Araki A., Yamada S., Inagaki T., Iida M., Noda S., Nakanishi H., Banno H., Mano T., Hirakawa A., Adachi H., Watanabe H., Yamamoto M., Sobue G.
    • Journal Title

      Ann Clin Transl Neurol

      Volume: 3 Issue: 7 Pages: 537-546

    • DOI

      10.1002/acn3.324

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Amyotrophic lateral sclerosis and motor neuron syndromes in Asia.2016

    • Author(s)
      Shahrizaila N., Sobue G., Kuwabara S., Kim SH., Birks C., Fan DS., Bae JS., Hu CJ., Gourie-Devi M., Noto Y., Shibuya K., Goh KJ., Kaji R., Tsai CP., Cui L., Talman P., Henderson RD., Vucic S., Kiernan MC.
    • Journal Title

      J Neurol Neurosurg Psychiatry

      Volume: 87 Issue: 8 Pages: 821-830

    • DOI

      10.1136/jnnp-2015-312751

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] R-spondin 2 promotes acetylcholine receptor clustering at the neuromuscular junction via Lgr5.2016

    • Author(s)
      Nakashima H., Ohkawara B., Ishigaki S., Fukudome T., Ito K., Tsushima M., Konishi H., Okuno T., Yoshimura T., Ito M., Masuda A., Sobue G., Kiyama H., Ishiguro N., Ohno K.
    • Journal Title

      Sci Rep

      Volume: 22 Issue: 1 Pages: 28512-28512

    • DOI

      10.1038/srep28512

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] A rapid functional decline type of amyotrophic lateral sclerosis is linked to low expression of TTN.2016

    • Author(s)
      Watanabe H, Atsuta N, Hirakawa A, Nakamura R, Nakatochi M, Ishigaki S, Iida A, Sobue G.
    • Journal Title

      J Neurol Neurosurg Psychiatry

      Volume: in press Issue: 8 Pages: 851-8

    • DOI

      10.1136/jnnp-2015-311541

    • Related Report
      2016 Annual Research Report 2015 Annual Research Report
    • Peer Reviewed
  • [Journal Article] MiR-298 Counteracts Mutant Androgen Receptor Toxicity in Spinal and Bulbar Muscular Atrophy2016

    • Author(s)
      Pourshafie N, Lee PR, Chen KL, Harmison GG, Bott LC, Katsuno M, Sobue G, Burnett BG, Fischbeck KH, Rinaldi C
    • Journal Title

      Mol Ther

      Volume: 24 Issue: 5 Pages: 937-45

    • DOI

      10.1038/mt.2016.13

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Next-generation sequencing of 28 ALS-related genes in a Japanese ALS cohort2016

    • Author(s)
      Ryoichi Nakamura, Jun Sone, Naoki Atsuta, Genki Tohnai, Hazuki Watanabe, Daichi Yokoi, Masahiro Nakatochi, Hirohisa Watanabe, Mizuki Ito, Jo Senda, Masahisa Katsuno, Fumiaki Tanaka, Yuanzhe Li, Yuishin Izumi, Mitsuya Morita, Akira Taniguchi, Osamu Kano, Masaya Oda, Satoshi Kuwabara, Koji Abe.
    • Journal Title

      Neurobiology of Aging

      Volume: 39 Pages: 219-219

    • DOI

      10.1016/j.neurobiolaging.2015.11.030

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Characteristic laryngoscopic findings in Parkinson's disease patients after subthalamic nucleus deep brain stimulation and its correlation with voice disorder2015

    • Author(s)
      Tsuboi, T. Watanabe, H. Tanaka, Y. Ohdake, R. Yoneyama, N. Hara, K. Ito, M. Hirayama, M. Yamamoto, M. Fujimoto, Y. Kajita, Y. Wakabayashi, T. Sobue, G.
    • Journal Title

      J Neural Transm (Vienna)

      Volume: 122 Issue: 12 Pages: 1663-72

    • DOI

      10.1007/s00702-015-1436-y

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Immunoglobulin G4-related pathologic features in inflammatory neuropathies.2015

    • Author(s)
      Ohyama K, Koike H, Takahashi M, Kawagashira Y, Iijima M, Watanabe H, Sobue G.
    • Journal Title

      Neurology.

      Volume: 85 Issue: 16 Pages: 1400-1407

    • DOI

      10.1212/wnl.0000000000002039

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Head Lift Exercise Improves Swallowing Dysfunction in Spinal and Bulbar Muscular Atrophy2015

    • Author(s)
      Mano T, Katsuno M, Banno H, Suzuki K, Suga N, Hashizume A, Araki A, Hijikata Y, Tanaka S, Takatsu J, Watanabe H, Yamamoto M, Sobue G
    • Journal Title

      Eur Neurol

      Volume: 74 Issue: 5-6 Pages: 251-258

    • DOI

      10.1159/000431088

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Astrocyte-Derived TGF-β1 Accelerates Disease Progression in ALS Mice by Interfering with the Neuroprotective Functions of Microglia and T Cells.2015

    • Author(s)
      Endo F, Komine O, Fujimori-Tonou N, Katsuno M, Jin S, Watanabe S, Sobue G, Dezawa M, Wyss-Coray T, Yamanaka K
    • Journal Title

      Cell Reports

      Volume: 11 Issue: 4 Pages: 592-604

    • DOI

      10.1016/j.celrep.2015.03.053

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] Voice features of Parkinson's disease patients with subthalamic nucleus deep brain stimulation.2015

    • Author(s)
      Tanaka Y, Tsuboi T, Watanabe H, Kajita Y, Fujimoto Y, Ohdake R, Yoneyama N, Masuda M, Hara K, Senda J, Ito M, Atsuta N, Horiguchi S, Yamamoto M, Wakabayashi T, Sobue G.
    • Journal Title

      J Neurol.

      Volume: 262 Issue: 5 Pages: 1173-1181

    • DOI

      10.1007/s00415-015-7681-z

    • Related Report
      2015 Annual Research Report 2014 Annual Research Report
    • Peer Reviewed
  • [Journal Article] FUS regulates AMPA receptor function and FTLD/ALS-associated behaviour via GluA1 mRNA stabilization.2015

    • Author(s)
      Udagawa, T., Fujioka, Y., Tanaka, M., Honda, D., Yokoi, S., Riku, Y., Ibi, D., Nagai, T., Yamada, K., Watanabe, H., Katsuno, M., Inada, T., Ohno, K., Sokabe, M., Okado, H., Ishigaki S*., and Sobue, G.
    • Journal Title

      Nat Commun

      Volume: 6 Issue: 1 Pages: 7098-7098

    • DOI

      10.1038/ncomms8098

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Evaluation of resting state networks in patients with gliomas: connectivity changes in the unaffected side and its relation to cognitive function.2015

    • Author(s)
      Maesawa S, Bagarinao E, Fujii M, Futamura M, Motomura K, Watanabe H, Mori D, Sobue G, Wakabayashi T.
    • Journal Title

      PLoS One

      Volume: 10 Issue: 2 Pages: e0118072-e0118072

    • DOI

      10.1371/journal.pone.0118072

    • Related Report
      2015 Annual Research Report 2014 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Pioglitazone suppresses neuronal and muscular degeneration caused by polyglutamine-expanded androgen receptors.2015

    • Author(s)
      Iida M, Katsuno M, Nakatsuji H, Adachi H, Kondo N, Miyazaki Y, Tohnai G, Ikenaka K, Watanabe H, Yamamoto M, Kishida K, Sobue G
    • Journal Title

      Hum Mol Genet.

      Volume: 24 Issue: 2 Pages: 314-329

    • DOI

      10.1093/hmg/ddu445

    • Related Report
      2015 Annual Research Report 2014 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Variants associated with Gaucher disease in multiple system atrophy2015

    • Author(s)
      Mitsui J, Matsukawa T, Sasaki H, Yabe I, Nakahara Y, Momose Y, Takahashi Y, Hara K, Kakita A, Yamada M, Takahashi H, Onodera O, Nishizawa M, Watanabe H, Nakashima K, Ito H, Izumi Y, Kaji R, Kato T, Tsuji S, et al.
    • Journal Title

      Ann Clin Transl Neurol.

      Volume: 2 Issue: 4 Pages: 417

    • DOI

      10.1002/acn3.185

    • URL

      https://localhost/en/publications/c946bad2-a238-4d0e-a396-6d33b3922ab7

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Meclozine promotes longitudinal skeletal growth in transgenic mice with achondroplasia carrying a gain-of-function mutation in the FGFR3 gene2015

    • Author(s)
      Matsushita M, Hasegawa S, Kitoh H, Mori K, Ohkawara B, Yasoda A, Masuda A, Ishiguro N, Ohno K,
    • Journal Title

      Endocrinology

      Volume: 156 Issue: 1 Pages: 584-554

    • DOI

      10.1016/j.fob.2014.11.007

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Contractile dysfunction in muscle may underlie androgen-dependent motor dysfunction in spinal bulbar muscular atrophy2015

    • Author(s)
      Oki K, Halievski K, Vicente L, Xu Y, Zeolla D, Poort J, Katsuno M, Adachi H, Sobue G, Wiseman RW, Breedlove SM, Jordan CL
    • Journal Title

      J Appl Physiol

      Volume: 118 Issue: 7 Pages: 941-52

    • DOI

      10.1152/japplphysiol.00886.2014

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Distinct phenotypes of speech and voice disorders in Parkinson's disease after subthalamic nucleus deep brain stimulation.2014

    • Author(s)
      Tsuboi T, Watanabe H, Tanaka Y, Ohdake R, Yoneyama N, Hara K, Nakamura R, Watanabe H, Senda J, Atsuta N, Ito M, Hirayama M, Yamamoto M, Fujimoto Y, Kajita Y, Wakabayashi T, Sobue G.
    • Journal Title

      J Neurol Neurosurg Psychiatry

      Volume: Epub Issue: 8 Pages: 856-64

    • DOI

      10.1136/jnnp-2014-308043

    • Related Report
      2015 Annual Research Report 2014 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Factors affecting longitudinal functional decline and survival in amyotrophic lateral sclerosis patients.2014

    • Author(s)
      Watanabe H, Atsuta N, Nakamura R, Hirakawa A, Watanabe H, Ito M, Senda J, Katsuno M, Izumi Y, Morita M, Tomiyama H, Taniguchi A, Aiba I, Abe K, Mizoguchi K, Oda M, Kano O, Okamoto K, Kuwabara S, Hasegawa K, Imai T, Aoki M, Tsuji S, Nakano I, Kaji R, Sobue G.
    • Journal Title

      Amyotroph Lateral Scler Frontotemporal Degener.

      Volume: Epub ahead of print Issue: 3-4 Pages: 230-6

    • DOI

      10.3109/21678421.2014.990036

    • Related Report
      2015 Annual Research Report 2014 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Endolymphatic space size in patients with vestibular migraine and Meniere's disease.2014

    • Author(s)
      Nakada T, Yoshida T, Suga K, Kato M, Otake H, Kato K, Teranishi M, Sone M, Sugiura S, Kuno K, Pyykko I, Naganawa S, Watanabe H, Sobue G, Nakashima T.
    • Journal Title

      J Neurol.

      Volume: 261(11) Issue: 11 Pages: 2079-2084

    • DOI

      10.1007/s00415-014-7458-9

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Hyposmia and cardiovascular dysautonomia correlatively appear in early-stage Parkinson's disease2014

    • Author(s)
      Mizutani, Y. Nakamura, T. Okada, A. Suzuki, J. Watanabe, H. Hirayama, M. Sobue, G.
    • Journal Title

      Parkinsonism & related disorders

      Volume: 20 Issue: 5 Pages: 520-4

    • DOI

      10.1016/j.parkreldis.2014.02.010

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Role of cardiac sympathetic nerves in preventing orthostatic hypotension in Parkinson's disease2014

    • Author(s)
      Nakamura, T. Hirayama, M. Hara, T. Mizutani, Y. Suzuki, J. Watanabe, H. Sobue, G.
    • Journal Title

      Parkinsonism Relat Disord

      Volume: 20 Issue: 4 Pages: 409-14

    • DOI

      10.1016/j.parkreldis.2014.01.003

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Early pathologic changes in hereditary diffuse leukoencephalopathy with spheroids.2014

    • Author(s)
      Riku Y, Ando T, Goto Y, Mano K, Iwasaki Y, Sobue G, Yoshida M
    • Journal Title

      J Neuropathol Exp Neurol

      Volume: 73 Issue: 12 Pages: 1183-90

    • DOI

      10.1097/nen.0000000000000139

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Differential motor neuron involvement in progressive muscular atrophy: a comparative study with amyotrophic lateral sclerosis2014

    • Author(s)
      Riku Y, Atsuta N, Yoshida M, Tatsumi S, Iwasaki Y, Mimuro M, Watanabe H, Ito M, Senda J, Nakamura R, Koike H, Sobue G
    • Journal Title

      BMJ Open

      Volume: 4 Issue: 5 Pages: e005213-e005213

    • DOI

      10.1136/bmjopen-2014-005213

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Identification and characterization of GABAA receptor autoantibodies in autoimmune encephalitis2014

    • Author(s)
      Ohkawa T, Satake S, Yokoi N, Miyazaki Y, Ohshita T, Sobue G, Takashima H, Watanabe O, *Fukata Y, *Fukata M (*corresponding author).
    • Journal Title

      J Neurosci

      Volume: 34 Issue: 24 Pages: 8151-8163

    • DOI

      10.1523/jneurosci.4415-13.2014

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Brugada syndrome in spinal and bulbar muscular atrophy.2014

    • Author(s)
      Araki A, Katsuno M, Suzuki K, Banno H, Suga N, Hashizume A, Mano T, Hijikata Y, Nakatsuji H, Watanabe H, Yamamoto M, Makiyama T, Ohno S, Fukuyama M, Morimoto S, Horie M, Sobue G
    • Journal Title

      Neurology

      Volume: 82 Issue: 20 Pages: 1813-1821

    • DOI

      10.1212/wnl.0000000000000434

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Paeoniflorin eliminates a mutant AR via NF-YA-dependent proteolysis in spinal and bulbar muscular atrophy.2014

    • Author(s)
      Tohnai G, Adachi H, Katsuno M, Doi H, Matsumoto S, Kondo N, Miyazaki Y, Iida M, Nakatsuji H, Qiang Q, Ding Y, Watanabe H, Yamamoto M, Ohtsuka K, Sobue G.
    • Journal Title

      Hum Mol Genet.

      Volume: 23 Issue: 13 Pages: 3552-3565

    • DOI

      10.1093/hmg/ddu066

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access
  • [Presentation] 大規模臨床、ゲノム、不死化細胞リソースを基盤としたオミックス解析による孤発性ALS治療法開発研究2019

    • Author(s)
      祖父江 元
    • Organizer
      AMED難治性疾患実用化研究事業成果報告会 東京
    • Related Report
      2018 Annual Research Report
  • [Presentation] Real world data analysis and modifier gene survey on ALS patients registry (JaCALS)2018

    • Author(s)
      祖父江 元
    • Organizer
      3rd Global ARO Network Workshop, Tokyo
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] JaCALS Registry Based Therapeutic Research in ALS2018

    • Author(s)
      祖父江 元
    • Organizer
      International Meeting of Pan-Asian Consortium for Treatment and Research in ALS (PACTALS), Seoul,
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] 認知症の病態と治療2018

    • Author(s)
      祖父江 元
    • Organizer
      第115回日本内科学会講演会 パネルディスカッション「日常診療における難治性疾患への対応とピットフォール」 京都
    • Related Report
      2018 Annual Research Report
    • Invited
  • [Presentation] FTLD/ALSの神経回路病態解明に基づく革新的診断治療開発2018

    • Author(s)
      祖父江 元
    • Organizer
      平成30年度第一回 革新脳臨床研究G分科会 東京
    • Related Report
      2018 Annual Research Report
  • [Presentation] ALSレジストリー研究(JaCALS)から見えるもの2018

    • Author(s)
      祖父江 元
    • Organizer
      第59回日本神経学会学術集会 シンポジウム「レジストリー・コホート研究が目指すもの - 病態解明・創薬に向けて」 札幌
    • Related Report
      2018 Annual Research Report
    • Invited
  • [Presentation] 神経変性疾患のdisease-modifying therapyの開発に向けて2018

    • Author(s)
      祖父江 元
    • Organizer
      第59回日本神経学会学術集会 イブニングセミナー 札幌
    • Related Report
      2018 Annual Research Report
    • Invited
  • [Presentation] 前頭側頭型認知症の分子標的治療薬・バイオマーカー開発によるdisease-modifying therapyへの展開2018

    • Author(s)
      祖父江 元
    • Organizer
      認知症チーム第5回分科会 東京
    • Related Report
      2018 Annual Research Report
  • [Presentation] FTLDの病態解明とそれに基づくタウisoformを標的とした核酸治療薬の開発2018

    • Author(s)
      祖父江 元
    • Organizer
      新学術領域(研究提案型)脳タンパク質老化と認知症制御 第8回班会議・第4回リトリート 東京
    • Related Report
      2018 Annual Research Report
  • [Presentation] 筋萎縮性側索硬化症患者のレジストリ構築:創薬促進に向けて2018

    • Author(s)
      祖父江 元
    • Organizer
      AMEDクリニカル・イノベーション・ネットワーク推進支援事業公開シンポジウム 東京
    • Related Report
      2018 Annual Research Report
  • [Presentation] 神経変性疾患のdisease-modifying therapyの開発2018

    • Author(s)
      祖父江 元
    • Organizer
      第41回日本神経科学大会 特別教育講演 神戸
    • Related Report
      2018 Annual Research Report
    • Invited
  • [Presentation] 運動ニューロン疾患の病態と治療 球脊髄性筋萎縮症(SBMA)に筋萎縮性硬化症(ALS)について2018

    • Author(s)
      祖父江 元
    • Organizer
      第14回日本神経筋摂食嚥下栄養研究会 名古屋
    • Related Report
      2018 Annual Research Report
    • Invited
  • [Presentation] FTLDの人および動物脳画像研究2018

    • Author(s)
      祖父江 元
    • Organizer
      平成29年度 第2回 革新脳臨床研究グループ分科会
    • Related Report
      2017 Annual Research Report
  • [Presentation] 神経変性疾患のdisease-modifying therapyの開発2018

    • Author(s)
      祖父江 元
    • Organizer
      創薬薬理フォーラム 第63回談話会
    • Related Report
      2017 Annual Research Report
  • [Presentation] Development of disease-modifying therapy for neurodegenerative diseases2018

    • Author(s)
      祖父江 元
    • Organizer
      第10回NAGOYAグローバルリトリート
    • Related Report
      2017 Annual Research Report
  • [Presentation] THK5351 imaging and neural network.2017

    • Author(s)
      祖父江 元
    • Organizer
      Brain Protein Aging and Dementia Control International Tau Symposium
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] SBMA (Kennedy’s disease) and ALS: Development of disease-modifying therapy.2017

    • Author(s)
      祖父江 元
    • Organizer
      XXIII World Congress of Neurology
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Perspectives of patient registry study for ALS From JaCALS2017

    • Author(s)
      祖父江 元
    • Organizer
      Summit Meeting for Global Registries of Stroke, Parkinson's disease, and ALS’ to construct a global stroke registry
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] JaCALS/FTLD-J2017

    • Author(s)
      祖父江 元
    • Organizer
      JaCALS/FTLD-J. Joint meeting of PACTALS and BRAIN PROTEIN AGING AND DEMENTIA CONTROL PROJECT
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 名古屋神経変性疾患のdisease-modifying therapyをめざして2017

    • Author(s)
      祖父江 元
    • Organizer
      第39回神経組織培養研究会
    • Related Report
      2017 Annual Research Report
  • [Presentation] Molecular mechanism and therapeutic approach for FUS-mediated FTLD/ALS.2017

    • Author(s)
      祖父江 元
    • Organizer
      2nd International Symposium on Protein Aging and Dementia Control
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Perspectives of Large-scale ALS Patient Registry Study.2017

    • Author(s)
      祖父江 元
    • Organizer
      The 5th Kyoto Course on Bioinformatics for Genomic Medicine International Symposium on Genomic Medicine-Genomics of Rare and Intractable Diseases,
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 前頭側頭型認知症の分子標的治療薬・バイオマーカー開発によるdisease-modifying therapyへの展開2017

    • Author(s)
      祖父江 元
    • Organizer
      平成29年度融合脳認知症チーム進捗報告会
    • Related Report
      2017 Annual Research Report
  • [Presentation] STN-DBS 後のパーキンソン病で認める発声・発話障害:その病態と対策2017

    • Author(s)
      渡辺宏久、勝野雅央、祖父江元
    • Organizer
      第43回関東機能的脳外科カンファレンス
    • Related Report
      2017 Annual Research Report
    • Invited
  • [Presentation] 放射線科医が知っておくべき神経内科領域の最近の話題2017

    • Author(s)
      渡辺宏久、勝野雅央、祖父江元
    • Organizer
      第37回神経放射線ワークショップ モーニングセミナー
    • Related Report
      2017 Annual Research Report
    • Invited
  • [Presentation] パーキンソン病の薬物療法の課題:ヒトにおける可視化技術の果たす役割2017

    • Author(s)
      渡辺宏久、勝野雅央、祖父江元
    • Organizer
      第32回日本大脳基底核研究会
    • Related Report
      2017 Annual Research Report
    • Invited
  • [Presentation] Neural network imaging and clinical features in patients with amyotrophic lateral sclerosis & frontotemporal lobar degeneration spectrum2017

    • Author(s)
      渡辺宏久、祖父江元
    • Organizer
      BrainConnects 2017
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] タウタンパク質の蓄積とconnectomics2017

    • Author(s)
      渡辺宏久、石垣診祐、祖父江元
    • Organizer
      タウ研究会2017
    • Related Report
      2017 Annual Research Report
    • Invited
  • [Presentation] 200年目のパーキンソン病:早期病態理解の進歩と展望2017

    • Author(s)
      渡辺宏久、勝野雅央、祖父江元
    • Organizer
      第49回日本臨床分子形態学会学術集会
    • Related Report
      2017 Annual Research Report
    • Invited
  • [Presentation] 蛋白特異的PETならびにMRI等を用いた、加齢およびパーキンソン病と関連疾患の可視化の現状2017

    • Author(s)
      渡辺宏久、祖父江元
    • Organizer
      第27回ブレイン・ファンクション・イメージング・カンファレンス
    • Related Report
      2017 Annual Research Report
    • Invited
  • [Presentation] Our interprofessional collaboration approach for favourable outcome of voice and speech in patient with Parkinson's disease after deep brain stimulation2017

    • Author(s)
      渡辺宏久、坪井崇、田中康博、藤本保志、中坪大輔、前澤聡、梶田泰一、勝野雅央、祖父江元
    • Organizer
      第76回日本脳神経外科学会学術集会
    • Related Report
      2017 Annual Research Report
    • Invited
  • [Presentation] パーキンソン病の衝動制御障害 update2017

    • Author(s)
      渡辺宏久、勝野雅央、祖父江元
    • Organizer
      第11回パーキンソン病・運動障害疾患コングレス
    • Related Report
      2017 Annual Research Report
    • Invited
  • [Presentation] Typical feature of MSA with videos2017

    • Author(s)
      渡辺宏久、祖父江元
    • Organizer
      2017 KMDS Autumn Symposium
    • Related Report
      2017 Annual Research Report
    • Invited
  • [Presentation] Clinical, genetic, and imaging features of multiple system atrophy2017

    • Author(s)
      渡辺宏久、祖父江元
    • Organizer
      2017 KMDS Autumn Symposium
    • Related Report
      2017 Annual Research Report
    • Invited
  • [Presentation] Development of a single cell analysis tool for neurological disorders on 2D-plate with positional information.2017

    • Author(s)
      Ishigaki S., Uno H., Wang Z-H., Ukita Y., Bhardwaj R., Tue P. T., Yurino H., Hashimoto S., Oka T., Kawahara K., Urisu T., Takamura Y., and Sobue G.
    • Organizer
      The 40th annual Meeting of the Japan Neuroscience Society
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Cooperative control of SynGAP isoform α2 mRNA stability by FUS and ELAV-like proteins promotes dendritic spine maturation and cognitive function2017

    • Author(s)
      Yokoi S, Udagawa T, Fujioka Y, Honda D, Okado H, Watanabe H, Katsuno M, Ishigaki S, Sobue G.
    • Organizer
      The 40th annual Meeting of the Japan Neuroscience Society
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Establishment of adeno-associated virus vector system for silencing FUS in common marmoset brain2017

    • Author(s)
      Endo K, Ishigaki S, Masamizu Y, Hatanaka N, Fujioka Y, Watakabe A, Yamamori T, Katsuno M, Watanabe H, Matsuzaki M, Nambu A, Sobue G.
    • Organizer
      The 40th annual Meeting of the Japan Neuroscience Society
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 3’UTR length-dependent control of SynGAP isoform α2 mRNA by FUS and ELAV-like proteins promotes dendritic spine maturation and cognitive function.2017

    • Author(s)
      Yokoi S, Udagawa T, Fujioka Y, Honda D, Okado H, Watanabe H, Katsuno M, Ishigaki S, Sobue G.
    • Organizer
      WCN 2017
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Silencing of FUS in the brain of non-human primates via stereotaxic injection of an adeno-associated virus encoding shRNA.2017

    • Author(s)
      Endo K, Ishigaki S, Fujioka Y, Watanabe H, Katsuno M, Sobue G.
    • Organizer
      WCN 2017
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Aberrant interaction between FUS and SFPQ in 4R-tau dominant tauopathy brains.2017

    • Author(s)
      Ishigaki S, Riku Y, Fujioka Y, Honda D, Yokoi S, Endo K., Kawai K, Watanabe H, Katsuno M, Sobue G.
    • Organizer
      The 47th Society for Neuroscience annual meeting
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Silencing of FUS in the non-human primate brain via stereotaxic injection of an adeno-associated virus encoding shRNA2017

    • Author(s)
      Endo K, Ishigaki S, Fujioka Y, Watanabe H, Katsuno M, Sobue G.
    • Organizer
      The 47th Society for Neuroscience annual meeting
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] FUS and ELAV-like proteins cooperatively control SynGAP isoform α2 in a 3'UTR length-dependent manner to promote dendritic spine maturation and cognitive function.2017

    • Author(s)
      Yokoi S, Udagawa T, Fujioka Y, Honda D, Okado H, Watanabe H, Katsuno M, Ishigaki S, Sobue G.
    • Organizer
      The 47th Society for Neuroscience annual meeting
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 神経難病の治療研究の現状と将来展望 球脊髄性筋萎縮症(SBMA)と筋萎縮性側索硬化症(ALS)の治験・レジストリ研究から2017

    • Author(s)
      祖父江 元
    • Organizer
      日本臨床試験学会第8回学術集会総会
    • Related Report
      2016 Annual Research Report
    • Invited
  • [Presentation] Accumulation of phosphorylated tau in neurons in FUS-silenced mice.2016

    • Author(s)
      Ishigaki S, Fujioka Y., Honda D, Yokoi S, Endo K, Okado H, Watanabe H, Katsuno M, Takashima A, Sobue G.
    • Organizer
      The 46th Society for Neuroscience annual meeting
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Loss of SFPQ, an intra-nuclear counterpart of FUS causes FTLD-like phenotypes.2016

    • Author(s)
      Fujioka Y, Ishigaki S, Yokoi S, Honda D, Okado H.
    • Organizer
      The 46th Society for Neuroscience annual meeting
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Skin-related dysautonomia and bladder dysfunction in PD.2016

    • Author(s)
      Watanabe H, Sobue G.
    • Organizer
      4th World Parkinson Congress Parallel Sessions
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 球脊髄性筋萎縮症のdisease-modifying therapyの開発について2016

    • Author(s)
      祖父江 元
    • Organizer
      第57回日本神経学会学術大会
    • Related Report
      2016 Annual Research Report
    • Invited
  • [Presentation] 新専門医制度にどう対応していくのか2016

    • Author(s)
      祖父江 元
    • Organizer
      第57回日本神経学会学術大会
    • Related Report
      2016 Annual Research Report
    • Invited
  • [Presentation] 脳タンパク質老化とマクロ、ミクロ神経回路破綻2016

    • Author(s)
      祖父江 元
    • Organizer
      新学術領域(研究提案型)脳タンパク質老化と認知症制御 第4回班会議・第2回学術領域研究リトリート
    • Related Report
      2016 Annual Research Report
  • [Presentation] 認知症の克服に向けて2016

    • Author(s)
      祖父江 元
    • Organizer
      第70回日本交通医学会総会
    • Related Report
      2016 Annual Research Report
    • Invited
  • [Presentation] 前頭側頭葉変性症(FTLD)/筋萎縮性側索硬化症(ALS)の神経回路破綻解明に基づく革新的治療開発2016

    • Author(s)
      祖父江 元
    • Organizer
      革新脳 臨床グループ・変性チーム分科会
    • Related Report
      2016 Annual Research Report
  • [Presentation] 認知症の病態に基づく治療開発 神経変性性認知症を中心に2016

    • Author(s)
      祖父江 元
    • Organizer
      認知症研究を知る若手研究者の集まり
    • Related Report
      2016 Annual Research Report
  • [Presentation] Visualization of tau protein accumulation and neural network breakdown with aging and dementia.2016

    • Author(s)
      祖父江 元
    • Organizer
      Brain Connects 2016
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 認知症に寄り添う~地域生活継続可能な社会に向けて~ 認知症の診断2016

    • Author(s)
      渡辺宏久、勝野雅央、祖父江元
    • Organizer
      日本医師会生涯教育協力講座
    • Related Report
      2016 Annual Research Report
  • [Presentation] 認知症の病態を可視化する:脳血管障害および脳タンパク質老化とマクロ神経回路破綻2016

    • Author(s)
      渡辺宏久、勝野雅央、祖父江元
    • Organizer
      第15回釧路ニューロサイエンスワークショップ
    • Related Report
      2016 Annual Research Report
  • [Presentation] 脳タンパク質老化とマクロ神経回路破綻2016

    • Author(s)
      渡辺宏久、勝野雅央、祖父江元
    • Organizer
      第46回新潟神経学夏期セミナー
    • Related Report
      2016 Annual Research Report
  • [Presentation] 前頭側頭型認知症の病態診断2016

    • Author(s)
      渡辺宏久、勝野雅央、祖父江元
    • Organizer
      第30回老年期認知症研究会
    • Related Report
      2016 Annual Research Report
  • [Presentation] 脳タンパク質老化とマクロ神経回路破綻の可視化2016

    • Author(s)
      渡辺宏久、勝野雅央、祖父江元
    • Organizer
      第8回お茶の水 Neuroimaging Conference
    • Related Report
      2016 Annual Research Report
  • [Presentation] パーキンソン病の脳内神経回路解析2016

    • Author(s)
      渡辺宏久、勝野雅央、祖父江元
    • Organizer
      第10回 パーキンソン病・運動障害疾患コングレス
    • Related Report
      2016 Annual Research Report
  • [Presentation] Disrupted functional connectivity in Parkinson's disease patients with severe olfactory dysfunction.2015

    • Author(s)
      Watanabe H, Yoneyama N, Bagarinao E, Hara K, Kawabata K, Imai K, Hirayama M, Tsuboi T, Katsuno M, Sobue G
    • Organizer
      The 9th International Congress of the Asian Society Against Dementia in Kumamoto
    • Place of Presentation
      KKR HOTEL KUMAMOTO(熊本県熊本市)
    • Year and Date
      2015-09-15
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Disrupted functional connectivity of amygdala-based networks in Parkinson's disease patients with severe olfactory dysfunction.2015

    • Author(s)
      Watanabe H, Bagarinao E, Yoneyama N, Hara K, Kawabata K, Imai K, Hirayama M, Tsuboi T, Sobue G
    • Organizer
      The 67th AAN Annual Meeting Washington, DC.
    • Place of Presentation
      The Walter E. Washington Convention Center in Washington, DC
    • Year and Date
      2015-04-23
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research
  • [Book] 認知症疾患診療ガイドライン20172017

    • Author(s)
      饗場郁子、秋下雅弘、粟田主一、飯島 節、池内 健、池田 学、猪原匡史、數井裕光、三條伸夫、東海林幹夫 、鈴木匡子、高橋牧郎、玉岡 晃、寺田整司、中西亜紀、羽生春夫、原 英夫、水上勝義、鷲見幸彦、和田健二、渡辺宏久
    • Total Pages
      384
    • Publisher
      医学書院
    • Related Report
      2017 Annual Research Report
  • [Book] 標準的神経治療 しびれ感2017

    • Author(s)
      福武敏夫、安藤哲朗、冨本 秀和、渡辺宏久他
    • Total Pages
      144
    • Publisher
      医学書院
    • Related Report
      2017 Annual Research Report
  • [Book] Clinical Assessment of the Autonomic Nervous System2016

    • Author(s)
      Watanabe H, Sobue G.
    • Total Pages
      317
    • Publisher
      Technical Considerations for MIBG Cardiac Scintigraphy
    • Related Report
      2016 Annual Research Report
  • [Book] Clinical Assessment of the Autonomic Nervous System2016

    • Author(s)
      Watanabe H, Sobue G.
    • Total Pages
      317
    • Publisher
      indings of MIBG Cardiac Scintigraphy: Dementia with Lewy Bodies and Related Dementia
    • Related Report
      2016 Annual Research Report
  • [Remarks] 脳タンパク質と認知症制御

    • URL

      http://www.protein-dementia.jp

    • Related Report
      2018 Annual Research Report
  • [Remarks] 領域ホームページ

    • URL

      http://www.protein-dementia.jp

    • Related Report
      2014 Annual Research Report
  • [Patent(Industrial Property Rights)] タウのスプライシングを制御するアンチセンスオリゴヌクレオチド及びその用途2018

    • Inventor(s)
      祖父江元、石垣診祐、佐橋健太郎、遠藤邦幸、閨正博、他
    • Industrial Property Rights Holder
      名古屋大学、神戸天然物化学㈱
    • Industrial Property Rights Type
      特許
    • Filing Date
      2018
    • Related Report
      2018 Annual Research Report
  • [Patent(Industrial Property Rights)] TDP-43の発現量を調節するアンチセンスオリゴヌクレオチド及びその用途2018

    • Inventor(s)
      祖父江元、石垣診祐、永井義隆、前田和宏、武内敏秀、閨正博、他
    • Industrial Property Rights Holder
      名古屋大学、大阪大学、神戸天然物化学㈱
    • Industrial Property Rights Type
      特許
    • Filing Date
      2018
    • Related Report
      2018 Annual Research Report
    • Overseas
  • [Patent(Industrial Property Rights)] TDP-43の発現量を調節するアンチセンスオリゴヌクレオチド及びその用途2017

    • Inventor(s)
      祖父江 元、石垣 診祐、佐橋 健太郎、永井 義隆、前田 和宏 他
    • Industrial Property Rights Holder
      名古屋大学
    • Industrial Property Rights Type
      特許
    • Filing Date
      2017
    • Related Report
      2017 Annual Research Report
    • Overseas
  • [Patent(Industrial Property Rights)] 疾患モデル動物および疾患治療剤2016

    • Inventor(s)
      祖父江元、石垣
    • Industrial Property Rights Holder
      名古屋大学
    • Industrial Property Rights Type
      特許
    • Filing Date
      2016
    • Related Report
      2016 Annual Research Report
  • [Funded Workshop] International Tau symposium2017

    • Related Report
      2017 Annual Research Report
  • [Funded Workshop] oint Meeting of “Brain Protein Aging and Dementia Control” project & Pan-Asia Consortium for Treatment and Research in ALS (PACTALS)2017

    • Related Report
      2017 Annual Research Report
  • [Funded Workshop] 2nd International Symposium of Brain Protein Aging and Dementia Control2017

    • Related Report
      2017 Annual Research Report
  • [Funded Workshop] International workshop2016

    • Related Report
      2016 Annual Research Report
  • [Funded Workshop] 第1回国際シンポジウム2015

    • Place of Presentation
      野依記念学術交流館(愛知県名古屋市)
    • Year and Date
      2015-10-09
    • Related Report
      2015 Annual Research Report

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Published: 2014-11-20   Modified: 2022-03-29  

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