| Budget Amount *help |
¥43,160,000 (Direct Cost: ¥33,200,000、Indirect Cost: ¥9,960,000)
Fiscal Year 2019: ¥9,230,000 (Direct Cost: ¥7,100,000、Indirect Cost: ¥2,130,000)
Fiscal Year 2018: ¥9,230,000 (Direct Cost: ¥7,100,000、Indirect Cost: ¥2,130,000)
Fiscal Year 2017: ¥9,230,000 (Direct Cost: ¥7,100,000、Indirect Cost: ¥2,130,000)
Fiscal Year 2016: ¥9,230,000 (Direct Cost: ¥7,100,000、Indirect Cost: ¥2,130,000)
Fiscal Year 2015: ¥6,240,000 (Direct Cost: ¥4,800,000、Indirect Cost: ¥1,440,000)
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| Outline of Final Research Achievements |
Polystyrene(PS)-supported phosphines are widely used for heterogeneous metal catalysis. The phosphine moieties have generally significant mobility even in cross-linked PS resins, and hence exhibit ligand properties similar to those of their homogeneous counterparts. In many cases, however, the polymer chain causes unfavorable steric effects, resulting in reduced catalyst efficiency. We prepared a new type of PS-phosphine hybrid (PS-DPPBz) through radical emulsion copolymerization of styrene monomers in the presence of tetravinylated 1,2-bis(diphenylphosphino)benzene. PS-DPPBz exhibited good swelling properties with aprotic organic solvents.
As a conceptual advance of our studies with solid-immobilized ligand toward enantioselective reactions, we showed that the BINOL-based monodentate phosphite chiral ligand enabled the highly enantioselective Ir-catalyzed directed borylation of unactivated methylene C(sp3)-H bonds in saturated hydrocarbon frameworks of substituted heteroarenes.
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