| Budget Amount *help |
¥115,830,000 (Direct Cost: ¥89,100,000、Indirect Cost: ¥26,730,000)
Fiscal Year 2019: ¥15,730,000 (Direct Cost: ¥12,100,000、Indirect Cost: ¥3,630,000)
Fiscal Year 2018: ¥15,730,000 (Direct Cost: ¥12,100,000、Indirect Cost: ¥3,630,000)
Fiscal Year 2017: ¥15,730,000 (Direct Cost: ¥12,100,000、Indirect Cost: ¥3,630,000)
Fiscal Year 2016: ¥15,730,000 (Direct Cost: ¥12,100,000、Indirect Cost: ¥3,630,000)
Fiscal Year 2015: ¥52,910,000 (Direct Cost: ¥40,700,000、Indirect Cost: ¥12,210,000)
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| Outline of Final Research Achievements |
Many metalloenzymes exist in nature and are responsible for various redox reactions and hydrolysis that support biosynthesis and metabolic degradation. The active centers are formed by unique metal cofactors which bind to the protein cavities, and the amino acid residues constituting the cavity act as a coordination sphere, controlling the activity and selectivity of the catalytic reactions. Learning from the structure of the metalloenzymes, our group has designed and created new biocatalysts consisting of artificial metal cofactors and protein reaction fields. These biocatalysts are found to promote several reactions, which may be highly difficult to convert substrates into products via C-H bond activation, C-C bond formation, or hydrogen generation.
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