| Budget Amount *help |
¥34,840,000 (Direct Cost: ¥26,800,000、Indirect Cost: ¥8,040,000)
Fiscal Year 2019: ¥7,410,000 (Direct Cost: ¥5,700,000、Indirect Cost: ¥1,710,000)
Fiscal Year 2018: ¥7,410,000 (Direct Cost: ¥5,700,000、Indirect Cost: ¥1,710,000)
Fiscal Year 2017: ¥7,410,000 (Direct Cost: ¥5,700,000、Indirect Cost: ¥1,710,000)
Fiscal Year 2016: ¥7,410,000 (Direct Cost: ¥5,700,000、Indirect Cost: ¥1,710,000)
Fiscal Year 2015: ¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
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| Outline of Final Research Achievements |
This study revealed that the helical poly(quinoxaline-2,3-diyl) scaffold provides highly effective chiral reaction environments for asymmetric catalysis, of which enantioselectivities are comparable or even superior to those obtained with low-molecular-weight chiral catalysts. Generality of the PQX scaffold as chiral catalysts was demonstrated by incorporation of various chiral catalyst pendants on the basis of copolymerization protocol, leading to the application to a wide array of asymmetric reactions with high enantioselectivities. The dynamic nature of the PQX scaffolds allows "chirality-amplifying" asymmetric catalysis in which chiral molecules with low enantiomeric excesses or those having weak nonbonding molecular interaction are used as sources of chirality. Through this research program, new possibilities of helical polymer scaffolds as a novel type of catalysts for asymmetric catalysis have been successfully demonstrated.
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