| Budget Amount *help |
¥69,420,000 (Direct Cost: ¥53,400,000、Indirect Cost: ¥16,020,000)
Fiscal Year 2019: ¥13,520,000 (Direct Cost: ¥10,400,000、Indirect Cost: ¥3,120,000)
Fiscal Year 2018: ¥13,520,000 (Direct Cost: ¥10,400,000、Indirect Cost: ¥3,120,000)
Fiscal Year 2017: ¥13,520,000 (Direct Cost: ¥10,400,000、Indirect Cost: ¥3,120,000)
Fiscal Year 2016: ¥13,520,000 (Direct Cost: ¥10,400,000、Indirect Cost: ¥3,120,000)
Fiscal Year 2015: ¥15,340,000 (Direct Cost: ¥11,800,000、Indirect Cost: ¥3,540,000)
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| Outline of Final Research Achievements |
A middle-sized molecule is effective in inhibiting protein-protein interactions, which cause various diseases; it should have hydrophobic groups to extend in at least three directions in order to interact with protein surface in a wide range. Therefore, we paid attention to three kinds of molecules, those are a molecule with multiple chiral centers, an axial chiral molecule, and an asymmetric cubic molecule, were synthesized very efficiently by the reaction integration method. To achieve this goal, we also investigated the flow method, which means a dissipative structure, but the tandem reaction in which the reactive species were automatically controlled was effective.
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