| Budget Amount *help |
¥166,790,000 (Direct Cost: ¥128,300,000、Indirect Cost: ¥38,490,000)
Fiscal Year 2019: ¥32,370,000 (Direct Cost: ¥24,900,000、Indirect Cost: ¥7,470,000)
Fiscal Year 2018: ¥32,500,000 (Direct Cost: ¥25,000,000、Indirect Cost: ¥7,500,000)
Fiscal Year 2017: ¥32,500,000 (Direct Cost: ¥25,000,000、Indirect Cost: ¥7,500,000)
Fiscal Year 2016: ¥32,500,000 (Direct Cost: ¥25,000,000、Indirect Cost: ¥7,500,000)
Fiscal Year 2015: ¥36,920,000 (Direct Cost: ¥28,400,000、Indirect Cost: ¥8,520,000)
|
|---|
| Outline of Final Research Achievements |
In vertebrates, the central nervous system (CNS) is established during early embryogenesis by the collective closing movement of a sheet of neural cells in a process called neural tube closure (NTC), and NTC failure causes a common human birth defect. During NTC, neuroepithelial cells change from a columnar to a wedge shape. As a common strategy for folding an epithelial sheet, this cellular morphogenesis, called apical constriction (AC), generates physical force to bend the neural plate (NP) inward. The lateral edges of the bending neural plate lift above the dorsal surface, eventually come together along the dorsal midline and fuse to form the neural tube. In this study, we investigated the mechanism of neural tissue folding focusing on cell shape change and physical properties such as stiffness of the tissue. We found that AC triggered by Ca2+ oscillation and subsequent stiffening of the neural epithelial tissue is essential for this morphogenesis.
|
