| Budget Amount *help |
¥157,560,000 (Direct Cost: ¥121,200,000、Indirect Cost: ¥36,360,000)
Fiscal Year 2019: ¥28,210,000 (Direct Cost: ¥21,700,000、Indirect Cost: ¥6,510,000)
Fiscal Year 2018: ¥28,340,000 (Direct Cost: ¥21,800,000、Indirect Cost: ¥6,540,000)
Fiscal Year 2017: ¥28,340,000 (Direct Cost: ¥21,800,000、Indirect Cost: ¥6,540,000)
Fiscal Year 2016: ¥28,340,000 (Direct Cost: ¥21,800,000、Indirect Cost: ¥6,540,000)
Fiscal Year 2015: ¥44,330,000 (Direct Cost: ¥34,100,000、Indirect Cost: ¥10,230,000)
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| Outline of Final Research Achievements |
The brain, including our human brain, is filled with a variety of oscillatory activity. The brain seems to utilize oscillatory mechanisms to accomplish its normal functions. On the other hand, abnormal oscillatory activity is often observed in disease states, and may be closely related to disease mechanisms. Analyzing oscillatory activity is important not only to understand disease mechanisms, but also to cure diseases. We investigate the relationship between oscillations and brain functions in deep brain structures, such as basal ganglia, and its relation to pathophysiology of neurological disorders using non-human primates and rodents. We investigated (1)Mechanism of voluntary movement control by oscillation and information transmission in the basal ganglia: cortico-basal ganglia information processing including somatotopy and center-surround organization, and (2)Pathophysiologcal mechanism of basal ganglia disorders and oscillation, especially Parkinson’s disease and dyskinesia.
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