Deep brain oscillation and motor control in primate and rodent models

• Project Area: Non-linear Neuro-oscillology: Towards Integrative Understanding of Human Nature
• Project/Area Number: 15H05873
• Research Category: Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)
• Allocation Type: Single-year Grants
• Review Section: Complex systems
• Research Institution: National Institute for Physiological Sciences
• Principal Investigator: 南部 篤 生理学研究所, システム脳科学研究領域, 教授 (80180553)
• Project Period (FY): 2015-06-29 – 2020-03-31
• Project Status: Granted (Fiscal Year 2019)
• Budget Amount: ¥157,560,000 (Direct Cost: ¥121,200,000、Indirect Cost: ¥36,360,000); Fiscal Year 2019: ¥28,210,000 (Direct Cost: ¥21,700,000、Indirect Cost: ¥6,510,000); Fiscal Year 2018: ¥28,340,000 (Direct Cost: ¥21,800,000、Indirect Cost: ¥6,540,000); Fiscal Year 2017: ¥28,340,000 (Direct Cost: ¥21,800,000、Indirect Cost: ¥6,540,000); Fiscal Year 2016: ¥28,340,000 (Direct Cost: ¥21,800,000、Indirect Cost: ¥6,540,000); Fiscal Year 2015: ¥44,330,000 (Direct Cost: ¥34,100,000、Indirect Cost: ¥10,230,000)
• Keywords: 脳・神経 / 脳神経疾患 / ソフトコンピューティング / 神経科学 / 生理学 / 脳、神経

Outline of Annual Research Achievements

霊長類、げっ歯類モデルでの脳深部振動と運動制御に関して、以下の研究を行った。
パーキンソン病の病態生理に関して、これまで大脳基底核や視床の神経活動が調べられており、平均発射頻度の変化や発射パターンの変化などが報告されてきた。これらの神経活動は最終的に大脳皮質に伝達されることにより、症状を発現していると考えられるが、大脳皮質の神経活動を調べた報告は少ない。そこで本年度は、パーキンソン病の病態を調べるため、ドーパミン神経毒であるMPTPを投与してパーキンソン病にしたニホンザルの一次運動野（M1）と補足運動野（SMA）から神経活動の記録を行った。パーキンソン病の際には、M1とSMAの神経活動のうち時間、周波数、非線形パラメータなどが変化していた。しかし、例えばパーキンソン病の際、M１の発射頻度は上昇するがSMAは変化しない、発射頻度のばらつきはM1では減少するがSMAでは不変、M1ではα帯域とβ帯域は増大するのに対し、SMAでは減少するなど、M1とSMAとで異なる変化を示した。概してM1の方がSMAに比べて、受ける影響が大きかった。このようなM1とSMAの複雑な変化は、感覚ー運動のコントロールの破綻によって特徴づけられるパーキンソン病の症状の複雑さを反映していると考えられる。M1とSMAの活動が異なることから、パーキンソン病は大脳皮質の神経活動に対して一様な影響を与えているのではないことがわかった。パーキンソン病の際の大脳皮質の神経活動を、今後も調べる必要がある。

Current Status of Research Progress

2: Research has progressed on the whole more than it was originally planned.

Reason

霊長類モデル、とくにパーキンソン病モデルを使った研究が順調に進んでいる。

Strategy for Future Research Activity

これらの成果を論文などにおいて発表する。また、今後ともパーキンソン病やジストニアなどの疾患モデルの解析に取り組む。

Research Products

• [Int'l Joint Research] Bar-Ilan 大学(イスラエル)
• [Int'l Joint Research] hm CINAC(スペイン)
• [Int'l Joint Research] 北京大学(中国)
• [Int'l Joint Research] スウェーデン王立工科大学(スウェーデン)
• [Int'l Joint Research] サウスアラバマ大学(アメリカ合衆国)
• [Int'l Joint Research] ケムニッツ工科大学(ドイツ)
• [Int'l Joint Research] ボルドー大学(フランス)
• [Int'l Joint Research] HM CINAC(スペイン)
• [Journal Article] Silencing of FUS in the common marmoset ( Callithrix jacchus ) brain via stereotaxic injection of an adeno-associated virus encoding shRNA (2018)
  • Author(s): Endo K, Ishigaki S, Masamizu Y, Fujioka Y, Watakabe A, Yamamori T, Hatanaka N, Nambu A, Okado H, Katsuno M, Watanabe H, Matsuzaki M, Sobue G
  • Journal Title: Neurosci Res. Volume: in press Pages: 30183-9
  • DOI: 10.1016/j.neures.2017.08.006
  • Peer Reviewed
• [Journal Article] The subthalamic nucleus-external globus pallidus loop biases exploratory decisions towards known alternatives: a neuro-computational study. (2018)
  • Author(s): Baladron J, Nambu A, Hamker F
  • Journal Title: Eur J Neurosci Volume: in press
  • DOI: 10.1111/ejn.13666
  • Peer Reviewed
• [Journal Article] Development of stereotaxic recording system for awake marmosets (Callithrix jacchus). (2018)
  • Author(s): Wakabayashi M, Koketsu D, Kondo H, Sato S, Ohara K, Polyakova Z, Chiken S, Hatanaka N, Nambu A
  • Journal Title: Neurosci Res Volume: in press
  • DOI: 10.1016/j.neures.2018.01.001
  • Peer Reviewed / Open Access
• [Journal Article] Rabies virus-mediated oligodendrocyte labeling reveals a singleoligodendrocyte myelinates axons from distinct brain regions (2017)
  • Author(s): Osanai Y, Shimizu T, Mori T, Yoshimura Y, Hatanaka N, Nambu A, Kimori Y, Koyama S, Kobayashi K, Ikenaka K.
  • Journal Title: GLIA Volume: 65 Pages: 93-105
  • DOI: 10.1002/glia.23076
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] Adeno-associated virus-mediated gene transfer into taste cells in vivo. (2017)
  • Author(s): Taruno A, Kashio M, Sun H, Kobayashi K, Sano H, Nambu A, Marunaka Y
  • Journal Title: Chemical Senses Volume: 42 Pages: 69-78
  • Peer Reviewed
• [Journal Article] Computational Model of Recurrent Subthalamo-Pallidal Circuit for Generation of Parkinsonian Oscillations. (2017)
  • Author(s): Shouno O, Tachibana Y, Nambu A and Doya K
  • Journal Title: Front. Neuroanat Volume: 11 Pages: 11-21
  • DOI: 10.3389/fnana.2017.00021
  • NAID: 120006406563
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Optogenctic activation of the sensorimotor cortex reveals "local inhibitory and global excitatory" inputs to the basal ganglia. (2017)
  • Author(s): Ozaki M, Sano H, Sato S, Ogura M, Mushiake H, Chiken S, Nakao N, Nambu A.
  • Journal Title: Cereb Cortex. Volume: 27 Pages: 5716-5726
  • DOI: 10.1093/cercor/bhx234
  • Peer Reviewed / Open Access
• [Journal Article] Information processing from the motor cortices to the subthalamic nucleus and globus pallidus and their somatotopic organizations revealed electrophysiologically in monkeys. (2017)
  • Author(s): Iwamuro H, Tachibana Y, Ugawa Y, Saito N, Nambu A
  • Journal Title: Eur J Neurosci Volume: 46 Pages: 2684-2701
  • DOI: 10.1111/ejn.13738
  • NAID: 120006456930
  • Peer Reviewed / Open Access
• [Journal Article] Zonisamide reduces nigrostriatal dopaminergic neurodegeneration in a mouse genetic model of Parkinson's disease. (2015)
  • Author(s): Sano H, Murata M, Nambu A.
  • Journal Title: J Neurochemi Volume: 134(2) Pages: 371-381
  • DOI: 10.1111/jnc.13116
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] opamine D1 receptor-mediated transmission maintains information flow through the cortico-striato-entopeduncular direct pathway to release movements. (2015)
  • Author(s): Chiken S, Sato A, Ohta C, Kurokawa M, Arai S, Maeshima J, Sunayama-Morita T, Sasaoka T, Nambu A
  • Journal Title: Cereb. Cortex Volume: 25 Pages: 4885-4897
  • DOI: 10.1093/cercor/bhv209
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Cause of parkinsonian symptoms: Firing rate, firing pattern or dynamic activity changes? (2015)
  • Author(s): Nambu A, Tachibana Y, Chiken S.
  • Journal Title: Basal Ganglia Volume: 5 Pages: 1-6
  • DOI: 10.1016/j.baga.2014.11.001
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Presentation] Pathophysiology of dystonia (2018)
  • Author(s): Atsushi Nambu
  • Organizer: Stockholm-Okazaki Workshop on "Multi-scale dynamics of basal ganglia in brain function and dysfunction"
  • Int'l Joint Research / Invited
• [Presentation] Physiological roles of striatal projection neurons revealed by optogenetics (2018)
  • Author(s): Hiromi Sano, Atsushi Nambu
  • Organizer: 第95回 日本生理学会大会
  • Invited
• [Presentation] マーモセットを用いた電気生理学的研究 (2018)
  • Author(s): 纐纈 大輔、南部 篤
  • Organizer: マーモセット研究会
• [Presentation] マーモセットの線条体ドーパミンD1、D2受容体の選択的ノックダウン法を用いた大脳基底核神経回路の機能解析 (2018)
  • Author(s): 纐纈 大輔、南部 篤
  • Organizer: 大脳基底核機能研究会
• [Presentation] The chemogenetic suppression of the primate subthalamic nucleus induces abnormal involuntary movements (2018)
  • Author(s): Taku Hasegawa, Satomi Chiken, Kenta Kobayashi, Atsushi Nambu
  • Organizer: 第95回日本生理学会大会
• [Presentation] Aberrant signalling of basal ganglia circuitry induces dyskinesia after chronic L-dopa administration in 6-hydroxydopamine mice (2018)
  • Author(s): Dwi Wahyu Indriani, Hiromi Sano, Satomi Chiken, Atsushi Nambu
  • Organizer: Stockholm-Okazaki Workshop on "Multi-scale dynamics of basal ganglia in brain function and dysfunction"
  • Int'l Joint Research / Invited
• [Presentation] Cortical control of monkey subthalamic nucleus (2018)
  • Author(s): Zlata Polyakova, Nobuhiko Hatanaka, Satomi Chiken, Atsushi Nambu
  • Organizer: 95th Annual Meeting of the Physiological Society of Japan.
• [Presentation] ネットワーク異常としてのパーキンソン病 (2018)
  • Author(s): 南部 篤
  • Organizer: 第６回ニューロカンファレンス和歌山
  • Invited
• [Presentation] 淡蒼球の機能解剖について (2018)
  • Author(s): 南部 篤
  • Organizer: 革新脳臨床G分科会
  • Invited
• [Presentation] 大脳皮質ー大脳基底核投射について (2018)
  • Author(s): 南部 篤
  • Organizer: 平成29年度京都大学霊長類研究所共同利用研究会「先端技術の導入による霊長類脳科学の進展と新たな概念の創出」
  • Invited
• [Presentation] Parkinson's disease as a network disorder (2018)
  • Author(s): Atsushi Nambu
  • Organizer: The 4th CiNet Conference, Neural oscillation and functional connectivity: from anatomy to perception
  • Int'l Joint Research / Invited
• [Presentation] "Inhibitory center-excitatory surround" inputs from the motor cortex to the globus pallidus revealed by optogenetic stimulation (2017)
  • Author(s): Atsushi Nambu
  • Organizer: 2017 Yonsei-Korean-NIPS Symposium
  • Int'l Joint Research
• [Presentation] The chemogenetic suppression of the primate subthalamic nucleus induces abnormal involuntary movements (2017)
  • Author(s): Taku Hasegawa, Satomi Chiken, Kenta Kobayashi, Atsushi Nambu
  • Organizer: International symposium, Neural Oscillation Conference 2017, Problems of Consciousness and Neuropsychiatric Disorders as Network Diseases
  • Int'l Joint Research
• [Presentation] Cortico-striatal induced responses in the basal ganglia (2017)
  • Author(s): Hiromi Sano, Kenta Kobayashi, Shigeki Sato, Satomi Chiken, Kazuto Kobayashi, Atsushi Nambu
  • Organizer: International symposium, Neural Oscillation Conference 2017, Problems of Consciousness and Neuropsychiatric Disorders as Network Diseases
  • Int'l Joint Research
• [Presentation] "Inhibitory center-excitatory surround" inputs from the motor cortex to the globus pallidus revealed by optogenetic stimulation (2017)
  • Author(s): Atsushi Nambu, Mitsunori Ozaki, Hiromi Sano, Shigeki Sato, Mitsuhiro Ogura, Hajime Mushiake, Satomi Chiken, Naoyuki Nakao
  • Organizer: International symposium, Neural Oscillation Conference 2017, Problems of Consciousness and Neuropsychiatric Disorders as Network Diseases
  • Int'l Joint Research
• [Presentation] 我慢をする脳内メカニズムー視床下核の新たな機能を探るー (2017)
  • Author(s): 橘 吉寿、南部 篤
  • Organizer: 第３２回日本大脳基底核研究会
• [Presentation] qAIM-MRIによるD1ドーパミン受容体コンディショナルノックダウンマウスの全脳神経活動解析 (2017)
  • Author(s): 小山内誠、菊田里美、谷平大樹、本間経康、中尾聡宏、小田佳奈子、笹岡俊邦、南部篤
  • Organizer: 第３２回日本大脳基底核研究会
• [Presentation] D1/D2ドーパミン受容体コンディショナル発現マウスによる運動制御機構の解明 (2017)
  • Author(s): 笹岡俊邦、佐藤朝子、知見聡美、大久保直、阿部学、川村名子、中尾聡宏、小田佳奈子、酒井清子、前田宣俊、神保幸弘、佐藤俊哉、藤澤信義、崎村建司、南部篤
  • Organizer: 第３２回日本大脳基底核研究会
• [Presentation] Differential involvement of direct- and indirect-pathway spiny projection neurons in action valuation and update in the dorsomedial striatum (2017)
  • Author(s): Minoru Kimura, Satoshi Nomura, Kayo Nishizawa, Kazuto Kobayashi, Yutaka Sakai, Yasuo Kawaguchi, Atsushi Nambu, Ko Yamanaka, Yoshikazu Isomura
  • Organizer: The 40th Annual Meeting of the Japan Neuroscicence Society
  • Invited
• [Presentation] Basal ganglia meet cerebellum: Introduction (2017)
  • Author(s): Atsushi Nambu
  • Organizer: The 40th Annual Meeting of the Japan Neuroscicence Society
  • Invited
• [Presentation] How do the basal ganglia and cerebellum control thalamocortical activity? (2017)
  • Author(s): Satomi Chiken, Atsushi Nambu
  • Organizer: The 40th Annual Meeting of the Japan Neuroscicence Society
  • Invited
• [Presentation] Elucidation of motor control mechanism using genetically mice harboring tetracycline-regulated expressiom of D1/D2 dopamine receptors (2017)
  • Author(s): Toshikuni Sasaoka, Asako Sato, Satomi Chiken, Tadashi Okubo, Manabe Abe, Meiko Kawamura, Satohiro Nakao, Kanako Oda, Seiko Sakai, Yoshitaka Maeba, Yukihiro Jimbo, Minoru Tanaka, Yoshitaka Yamamoto, Toshiya Sato, Nobuyoshi, Fujisawa, Kenji Sakimura Atsushi Nambu
  • Organizer: The 40th Annual Meeting of the Japan Neuroscicence Society
• [Presentation] Subthalamic neurons signal vigor of reward-seeking actions (2017)
  • Author(s): Yoshihisa Tachibana, Atsushi Nambu
  • Organizer: The 40th Annual Meeting of the Japan Neuroscicence Society
• [Presentation] Responses in the basal ganglia induced by cortico-striatal neurons (2017)
  • Author(s): Hiromi Sano, Kenta Kobayashi, Shigeki Kato, Satomi Chiken, Kazuto Kobayashi, Atsushi Nambu
  • Organizer: The 40th Annual Meeting of the Japan Neuroscicence Society
• [Presentation] Motor commands transferred from the deep cerebellar nuclei to the motor cortex (2017)
  • Author(s): Nobuya Sano, Yoshihisa Nakayama, Eiji Hoshi, Satomi Chiken, Atsushi Nambu, Yukio Nishimura
  • Organizer: The 40th Annual Meeting of the Japan Neuroscicence Society
• [Presentation] How do the basal ganglia and cerebellum control thalamocortical activity? (2017)
  • Author(s): Satomi Chiken, Atsushi Nambu
  • Organizer: International Workshop on Basal Ganglia Functions 2017
  • Invited
• [Presentation] 大脳皮質－大脳基底核ループとパーキンソン病 (2017)
  • Author(s): 知見聡美、南部篤
  • Organizer: 生理研研究会「脳の階層的理解を目指して」
  • Invited
• [Presentation] Basal ganglia and cerebellar control of tharamocortical activity (2017)
  • Author(s): Satomi Chiken, Atsushi Nambu
  • Organizer: 7th NIPS-CIN Joint Symosium
  • Int'l Joint Research / Invited
• [Presentation] Functional analysis of Rho/Rho-kinase signaling pathway in corticostriatal neuron survival using a new gene delivery system (2017)
  • Author(s): Kenta Kobayash, Hiromi Sano, Shigeki Kato, Keisuke Kuroda, Shinichi Nakamuta, Tadashi Isa, Atsushi Nambu, Kozo Kaibuchi, Kazuto Kobayashi
  • Organizer: The 40th Annual Meeting of the Japan Neuroscicence Society
• [Presentation] マウス神経麻痺性角膜症モデルに対する三叉神経節でのTRPV４強制発現による治療効果 (2017)
  • Author(s): 岡田由香、富永真琴、佐野裕美、小林憲太、南部篤、雑賀司珠也
  • Organizer: 第47回日本創傷治癒学会
• [Presentation] Concurrent activation of striatal medium spiny neurons induces involuntary movements similar to L-DOPA induced dyskinesia (2017)
  • Author(s): Hiromi Sano, Kenji F Tanaka, Atsushi Nambu
  • Organizer: International Symposium on Adaptive Circuit Shift 2017, Behavioral adaptation and functional recovery from pathological states
  • Int'l Joint Research
• [Presentation] マーモセット前頭皮質の神経生理学的マッピング (2017)
  • Author(s): 纐纈 大輔、南部 篤
  • Organizer: 生理学研究所研究会＠東北
• [Presentation] Correlated activity in globus pallidus neurons of a macaque monkey during hand reaching movements (2017)
  • Author(s): Woranan Wongmassang, Satomi Chiken, Taku Hasegawa, Atsushi Nambu
  • Organizer: Society for Neuroscience 2017
  • Int'l Joint Research
• [Presentation] Correlated activity in globus pallidus neurons of a macaque monkey during hand reaching movements (2017)
  • Author(s): Woranan Wongmassang, Satomi Chiken, Taku Hasegawa, Atsushi Nambu
  • Organizer: 生理学研究所研究会「脳の階層的理解を目指して」
• [Presentation] Cortical control of monkey subthalamic nucleus (2017)
  • Author(s): Zlata Polyakova, Nobuhiko Hatanaka, Satomi Chiken, Atsushi Nambu
  • Organizer: Tohoku-NIPS symposium
• [Presentation] Cortical control of monkey subthalamic nucleus (2017)
  • Author(s): Zlata Polyakova, Nobuhiko Hatanaka, Satomi Chiken, Atsushi Nambu
  • Organizer: 7th NIPS-CIN (Tuebingen University) symposium
• [Presentation] Cortico-basal ganglia loop and movement disorders (2017)
  • Author(s): Atsushi Nambu
  • Organizer: McGill-NISP symposium
  • Int'l Joint Research / Invited
• [Presentation] 大脳基底核と小脳の生理と病態：基礎医学の視点から (2017)
  • Author(s): 南部 篤
  • Organizer: 第１１回パーキンソン病・運動障害疾患コングレス
  • Invited
• [Presentation] Cortico-basal ganglia loop and pathophysiology of movement disorders (2017)
  • Author(s): Atsushi Nambu
  • Organizer: 15th Chinese Biophysics Congress
  • Int'l Joint Research / Invited
• [Presentation] 大脳皮質ー大脳基底核ループとパーキンソン病 (2017)
  • Author(s): 南部 篤
  • Organizer: 第２回Osaka Neurology Colloquim
  • Invited
• [Presentation] 大脳皮質ー大脳基底核ループと運動異常症の病態生理 (2017)
  • Author(s): 南部 篤
  • Organizer: 徳島大学研究クラスター 重点クラスター・選定（脳科学）クラスター合同セミナー
  • Invited
• [Presentation] Increased variability in globus pallidus interna in Parkinson's disease. (2017)
  • Author(s): Chiken S, Kumar A, Nambu A, Spreize S
  • Organizer: The Nordic Neuroscience 2017
  • Int'l Joint Research
• [Presentation] Action-specific reinforcement and update by direct- and indirect- pathway striatal projection neurons (2017)
  • Author(s): S. Nonomura, K. Nishizawa, K. Kobayashi, Y. Sakai, Y. Kawaguchi, A. Nambu, K. Yamanaka, K. Enomoto, Y. Isomura, M. Kimura
  • Organizer: Society for Neuroscience 2017
  • Int'l Joint Research
• [Presentation] 大脳皮質ー大脳基底核ループとパーキンソン病 (2017)
  • Author(s): 南部 篤
  • Organizer: 宮城パーキンソン病フォーラム
  • Invited
• [Presentation] Chemogenetic Control of Neuronal Activity in the Primate Subthalamic Nucleus. (2016)
  • Author(s): Hasegawa T, Chiken S, Kobayashi K, Nambu A
  • Organizer: 第９３回日本生理学会大会
  • Place of Presentation: 北海道 札幌市 札幌コンベンションセンター
  • Year and Date: 2016-03-24
• [Presentation] Parkinson’s disease as a network disorder. (2016)
  • Author(s): Chiken S, Nambu A
  • Organizer: 第９３回日本生理学会大会シンポジウム「ネットワーク病としての神経・精神疾患」
  • Place of Presentation: 北海道 札幌市 札幌コンベンションセンター
  • Year and Date: 2016-03-23
  • Invited
• [Presentation] パーキンソン病の病態生理について (2016)
  • Author(s): 南部 篤
  • Organizer: 京大霊長研共同利用研究会「霊長類脳科学の新しい展開とゲノム科学の融合」
  • Place of Presentation: 愛知県 犬山市 京都大学霊長類研究所
  • Year and Date: 2016-03-12
  • Invited
• [Presentation] パーキンソン病モデルサルにおける大脳皮質－大脳基底核路の情報伝達異常 (2016)
  • Author(s): 知見聡美、南部篤
  • Organizer: 次ステージ機能生命科学の展望
  • Place of Presentation: 愛知県 岡崎市 生理学研究所
  • Year and Date: 2016-03-10
• [Presentation] Physiological roles of striatal projection neurons in voluntary movements (2016)
  • Author(s): Sano H, Tanaka KF, Nambu A
  • Organizer: ACS2016
  • Place of Presentation: 京都府 京都市 同志社大学
  • Year and Date: 2016-03-03
  • Int'l Joint Research
• [Presentation] 科学と社会 科学への信用、信頼 (2016)
  • Author(s): 南部 篤
  • Organizer: 科学知の総合化シンポジウム
  • Place of Presentation: 東京都 中央区 東京コンベンションホール
  • Year and Date: 2016-02-20
  • Invited
• [Presentation] ネットワーク異常としてパーキンソン病を考える (2015)
  • Author(s): 南部 篤
  • Organizer: 第20回システム神経科学セミナー
  • Place of Presentation: 東京都 小平市 国立精神・神経医療研究センター神経研究所
  • Year and Date: 2015-12-21
  • Invited
• [Presentation] 大脳基底核の機能からパーキンソン病を理解する (2015)
  • Author(s): 南部 篤
  • Organizer: ハッピーフェイスセミナー in 宮崎
  • Place of Presentation: 宮崎県 宮崎市 宮崎観光ホテル
  • Year and Date: 2015-12-09
  • Invited
• [Presentation] システム神経科学がめざすもの (2015)
  • Author(s): 南部 篤
  • Organizer: 生理学研究所研究会「行動システム脳科学の新展開」
  • Place of Presentation: 愛知県岡崎市 生理学研究所
  • Year and Date: 2015-12-05
  • Invited
• [Presentation] Basal ganglia and cerebellar control of thalamocortical activity (2015)
  • Author(s): Chiken S, Sano H, Kawaguchi Y, Kimura M, Nambu A
  • Organizer: 8th FAOPS Congress
  • Place of Presentation: Bangkok Convention Centre, Bangkok, Thailand
  • Year and Date: 2015-11-24
  • Int'l Joint Research
• [Presentation] Correlated pallidal activity during voluntary reaching movements in a macaque monkey (2015)
  • Author(s): Woranan W, Chiken S, Nambu A
  • Organizer: 8th FAOPS Congress
  • Place of Presentation: Bangkok Convention Centre, Bangkok, Thailand
  • Year and Date: 2015-11-24
  • Int'l Joint Research
• [Presentation] Functions of the cortico-subthalamic hypedirect pathway investigated by a photodynamic technique (2015)
  • Author(s): Nambu A, Koketsu D, Chiken S, Hisatsune T, Miyachi S
  • Organizer: 8th FAOPS Congress
  • Place of Presentation: Bangkok Convention Centre, Bangkoku, Thailand
  • Year and Date: 2015-11-24
  • Int'l Joint Research
• [Presentation] 霊長類のパーキンソン病モデルにおける神経ネットワーク活動の解析と新規治療法への展望 (2015)
  • Author(s): 南部 篤
  • Organizer: CREST合同ワークショップ
  • Place of Presentation: 東京都 千代田区 AMED
  • Year and Date: 2015-11-19
  • Invited
• [Presentation] Pallidal and cerebellar control of thalamocortical activity (2015)
  • Author(s): Chiken S, Nambu A
  • Organizer: 5th NIPS-CIN Joint Symposium
  • Place of Presentation: 愛知県岡崎市 生理学研究所
  • Year and Date: 2015-11-05
  • Int'l Joint Research
• [Presentation] Dopamine D1 receptor activation maintains information flow through the cortico-basal ganglia direct pathway to release movements. (2015)
  • Author(s): Chiken S, Sato A, Sasaoka T, Nambu A
  • Organizer: International Symposium on Prediction and Decision Making
  • Place of Presentation: 東京都 文京区 東京大学小柴ホール
  • Year and Date: 2015-10-31
• [Presentation] Cortically induced responses in the basal ganglia through the cortico-striatal neurons (2015)
  • Author(s): Hiromi Sano, Kenta Kobayashi, Satomi Chiken, Shigeki Kato, Kazuto Kobayashi, Atsushi Nambu
  • Organizer: Neuroscience 2015
  • Place of Presentation: McCormick Place, Chicago, USA
  • Year and Date: 2015-10-17
• [Presentation] 大脳皮質ー大脳基底核ループとパーキンソン病 (2015)
  • Author(s): 南部 篤
  • Organizer: 第５回パーキンソン病QOL懇話会
  • Place of Presentation: 広島県 広島市 ホテルグランビア広島
  • Year and Date: 2015-09-30
  • Invited
• [Presentation] Abnormal neuronal activity of the basal ganglia in a transgenic mouse model of dopa-responsive dystonia with sepiapterin reductase deficiency (2015)
  • Author(s): Kubota H, Chiken S, Homma D, Takakusaki K, Ichinose H, Nambu A
  • Organizer: 第３８回日本神経科学大会
  • Place of Presentation: 兵庫県 神戸市 神戸国際会議場
  • Year and Date: 2015-07-30
• [Presentation] Neuronal responses in the basal ganglia evoked by optical stimulation of mice motor cortex (2015)
  • Author(s): Ozaki M, Sano H, Chiken S, Ogura M, Nakao N, Nambu A
  • Organizer: 第３８回日本神経科学大会
  • Place of Presentation: 兵庫県 神戸市 神戸国際会議場
  • Year and Date: 2015-07-30
• [Presentation] D1 dopamine receptor-mediated signal is required to maintain normal motor activity (2015)
  • Author(s): Sasaoka T, Sato A, Chiken S, Maeshima J, Arai S, Sunayama-Morita T, Oda K, Maeda Y, Sakai S, Jinbo Y, Umakawa E, Sato T, Okubo T, Fujisawa N, Yokoyama M, Nambu A
  • Organizer: 第３８回日本神経科学大会
  • Place of Presentation: 兵庫県 神戸市 神戸国際会議場
  • Year and Date: 2015-07-30
• [Presentation] Basal ganglia activity in a mouse model of dyskinesia (2015)
  • Author(s): Indriani DW, Sano H, Chiken S, Nambu A
  • Organizer: 第３８回日本神経科学大会
  • Place of Presentation: 兵庫県 神戸市 神戸国際会議場
  • Year and Date: 2015-07-30
• [Presentation] Abnormal information flow through the cortico-basal ganglia circuits in MPTP-treated parkinsonian monkeys (2015)
  • Author(s): Chiken S, Takada M, Nambu A
  • Organizer: 第３８回日本神経科学大会
  • Place of Presentation: 兵庫県 神戸市 神戸国際会議場
  • Year and Date: 2015-07-30
• [Presentation] Examination for possible involvement of the vestibular and reticular nuclei in the emergence for dystonia-like movements in Dystonin-deficient mice (2015)
  • Author(s): Horie M, Sano H, Chiken S, Kobayashi K, Ono K, Nambu A, Takebayashi H
  • Organizer: 第３８回日本神経科学大会
  • Place of Presentation: 兵庫県 神戸市 神戸国際会議場
  • Year and Date: 2015-07-28
• [Presentation] システム神経生理学：これまでの３０年、これからの２０年 (2015)
  • Author(s): 南部 篤
  • Organizer: 第３８回日本神経科学大会
  • Place of Presentation: 兵庫県 神戸市 神戸国際会議場
  • Year and Date: 2015-07-28
  • Invited
• [Remarks] 大脳皮質から大脳基底核へ情報が伝わる様子を、光を使って解明
  • URL: http://www.nips.ac.jp/release/2017/09/post_349.html
• [Remarks] 生理学研究所生体システム研究部門
  • URL: http://www.nips.ac.jp/sysnp/
• [Remarks] ドーパミン神経伝達は、大脳基底核における運動情報伝達と、運動発現に不可欠
  • URL: http://www.nips.ac.jp/release/2015/10/_d1.html
• [Patent(Industrial Property Rights)] 脳における電気的活動取得装置及びその利用 (2015)
  • Inventor(s): 南部篤、知見聡美、西村幸男、高良沙幸
  • Industrial Property Rights Holder: 大学共同利用機関法人自然科学研究機構
  • Industrial Property Rights Type: 特許
  • Filing Date: 2015
  • Application Year: 2015
  • Acquisition Date: 2018
  • Acquisition Year: 2018