| Budget Amount *help |
¥94,900,000 (Direct Cost: ¥73,000,000、Indirect Cost: ¥21,900,000)
Fiscal Year 2019: ¥19,630,000 (Direct Cost: ¥15,100,000、Indirect Cost: ¥4,530,000)
Fiscal Year 2018: ¥18,720,000 (Direct Cost: ¥14,400,000、Indirect Cost: ¥4,320,000)
Fiscal Year 2017: ¥19,110,000 (Direct Cost: ¥14,700,000、Indirect Cost: ¥4,410,000)
Fiscal Year 2016: ¥18,720,000 (Direct Cost: ¥14,400,000、Indirect Cost: ¥4,320,000)
Fiscal Year 2015: ¥18,720,000 (Direct Cost: ¥14,400,000、Indirect Cost: ¥4,320,000)
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| Outline of Final Research Achievements |
Based on a special electron microscopic technique using quick-frozen cells, new methods were established to enable observation of nano-scale distribution of functionally important phospholipids, including phosphatidylserine, in cellular membranes. By using the new method, TMEM16K, a protein in the endoplasmic reticulum, was revealed to have a function of induce redistribution of phospholipids in intracellular membranes. The membrane shaping by the membrane binding proteins were studied and membrane properties dependent on the lipid species were found to play crucial roles. Several new membrane shaping proteins and their membrane shaping mechanisms were revealed.
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