| Budget Amount *help |
¥152,620,000 (Direct Cost: ¥117,400,000、Indirect Cost: ¥35,220,000)
Fiscal Year 2019: ¥28,210,000 (Direct Cost: ¥21,700,000、Indirect Cost: ¥6,510,000)
Fiscal Year 2018: ¥28,730,000 (Direct Cost: ¥22,100,000、Indirect Cost: ¥6,630,000)
Fiscal Year 2017: ¥29,250,000 (Direct Cost: ¥22,500,000、Indirect Cost: ¥6,750,000)
Fiscal Year 2016: ¥30,550,000 (Direct Cost: ¥23,500,000、Indirect Cost: ¥7,050,000)
Fiscal Year 2015: ¥35,880,000 (Direct Cost: ¥27,600,000、Indirect Cost: ¥8,280,000)
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| Outline of Final Research Achievements |
In this study, in order to elucidate the roles of phospholipase A2 (PLA2) and prostaglandin (PG) receptors in diseases and the molecular mechanisms therein, we analyzed disease-like phenotypes in PLA2- or PG receptor-knockout mice. 1) We clarified the crystal structure of human EP4 and found that EP4 has a ligand access pocket opening toward plasma membrane. 2) We found that particular PG receptors are involved in myocyte reprogramming and gut microbiota-related responses in a lipoquality-dependent manner. 3) In white adipose tissues, PGE2 produced via PNPLA2/COX-1 by acting on EP4 receptor facilitates basal lipolysis and fat accumulation in liver.
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