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Understanding human diseases from the viewpoint of lipoquality

Planned Research

Project AreaQuality of lipids in biological systems
Project/Area Number 15H05906
Research Category

Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)

Allocation TypeSingle-year Grants
Review Section Biological Sciences
Research InstitutionThe University of Tokyo

Principal Investigator

Yatomi Yutaka  東京大学, 医学部附属病院, 教授 (60200523)

Co-Investigator(Kenkyū-buntansha) 本田 哲也  京都大学, 医学研究科, 講師 (40452338)
Project Period (FY) 2015-06-29 – 2020-03-31
Project Status Completed (Fiscal Year 2019)
Budget Amount *help
¥94,770,000 (Direct Cost: ¥72,900,000、Indirect Cost: ¥21,870,000)
Fiscal Year 2019: ¥18,460,000 (Direct Cost: ¥14,200,000、Indirect Cost: ¥4,260,000)
Fiscal Year 2018: ¥18,590,000 (Direct Cost: ¥14,300,000、Indirect Cost: ¥4,290,000)
Fiscal Year 2017: ¥20,410,000 (Direct Cost: ¥15,700,000、Indirect Cost: ¥4,710,000)
Fiscal Year 2016: ¥20,410,000 (Direct Cost: ¥15,700,000、Indirect Cost: ¥4,710,000)
Fiscal Year 2015: ¥16,900,000 (Direct Cost: ¥13,000,000、Indirect Cost: ¥3,900,000)
Keywordsリポクオリティ / ヒト臨床サンプル / 動脈硬化性疾患 / 癌 / 神経障害性疼痛 / 皮膚疾患 / ヒト臨床検体 / リゾリン脂質 / エイコサノイド / 動脈硬化 / 神経障害疼痛 / ヒト検体 / 動脈硬化症 / アトピー性皮膚炎 / 冠動脈疾患 / 皮膚科疾患 / 分子種 / 臨床 / 内科 / 免疫学 / 生理活性 / 脂質 / アレルギー / プロスタグランジン / 肝癌 / 乾癬 / 腹膜癌腫症
Outline of Final Research Achievements

We have elucidated the importance of "Lipoquality" in the pathogenesis of human disaseses, especially atherosclerosis, cancer, neuropathic pain, and skin diseases, by integrated approach of clinical studies and basic study. We measured and analyzed lipids and their related proteins using human samples such as blood, cerebrospinal fluid, urine, and surgical specimen and based on the results from these clinical studies, we performed basic experiments using animals and cells to elucidate the underlying mechanisms and possible therapeutic application. From this research, we have shown that the field of "Lipoquality" could develop through further translational researches in the future.

Academic Significance and Societal Importance of the Research Achievements

本研究の学術的意義は、基礎研究から提唱されていたリポクオリティの重要性が実際のヒト疾患にもあてはまる可能性を提唱できたことである。特に、未だ治療法・予防法が十分でない、動脈硬化性疾患、癌、神経障害性疼痛、アレルギー・乾癬といった皮膚疾患において、リポクオリティの重要性を発見することができたことは意義深い。このことから、将来のトランスレーショナルリサーチを通じて、リポクオリティの臨床検査および疾患治療・予防法の確立へとつながることが期待できる。

Report

(6 results)
  • 2019 Annual Research Report   Final Research Report ( PDF )
  • 2018 Annual Research Report
  • 2017 Annual Research Report
  • 2016 Annual Research Report
  • 2015 Annual Research Report
  • Research Products

    (116 results)

All 2020 2019 2018 2017 2016 2015 Other

All Int'l Joint Research (1 results) Journal Article (46 results) (of which Int'l Joint Research: 5 results,  Peer Reviewed: 45 results,  Open Access: 27 results,  Acknowledgement Compliant: 7 results) Presentation (63 results) (of which Int'l Joint Research: 20 results,  Invited: 6 results) Book (1 results) Remarks (4 results) Funded Workshop (1 results)

  • [Int'l Joint Research] マイアミ大学(米国)

    • Related Report
      2018 Annual Research Report
  • [Journal Article] Analysis of urinary sphingolipids using liquid chromatography-tandem mass spectrometry in diabetic nephropathy.2020

    • Author(s)
      Morita Y, Kurano M, Sakai E, Nishikawa T, Nishikawa M, Sawabe M, Aoki J, Yatomi Y.
    • Journal Title

      J Diabetes Investig

      Volume: 11 Issue: 2 Pages: 441-449

    • DOI

      10.1111/jdi.13154

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Protection against insulin resistance by apolipoprotein M/sphingosine-1-phosphate2020

    • Author(s)
      Kurano M, Tsukamoto K, Shimizu T, Kassai H, Nakao K, Aiba A, Hara M, Yatomi Y.
    • Journal Title

      Diabetes

      Volume: 69 Issue: 5 Pages: 867

    • DOI

      10.2337/db19-0811

    • NAID

      40022523253

    • URL

      https://pure.teikyo.jp/en/publications/a3d6e058-c85d-4ca5-b6af-142fe379f161

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Elevated phosphatidylserine-specific phospholipase A1 level in hyperthyroidism.2020

    • Author(s)
      Nakawatari K, Kurano M, Araki O, Nishikawa M, Shimamoto S, Igarashi K, Aoki J, Murakami M, Yatomi Y.
    • Journal Title

      Clin Chim Acta.

      Volume: 503 Pages: 99-106

    • DOI

      10.1016/j.cca.2020.01.011

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Possible involvement of PS-PLA1 and lysophosphatidylserine receptor (LPS1) in hepatocellular carcinoma.2020

    • Author(s)
      Uranbileg B, Kurano M, Sato M, Ikeda H, Ishizawa T, Hasegawa K, Kokudo N, Yatomi Y.
    • Journal Title

      Sci Rep.

      Volume: 10 Issue: 1 Pages: 2659-2659

    • DOI

      10.1038/s41598-020-59590-3

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Establishment of a Measurement System for Sphingolipids in the cerebrospinal fluid based on liquid chromatography-tandem mass spectrometry, and its application in the diagnosis of carcinomatous meningitis2020

    • Author(s)
      Sakai E, Kurano M, Morita Y, Aoki J, Yatomi Y
    • Journal Title

      J Appl Lab Med

      Volume: NA

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Serum autotaxin levels are associated with Graves’ disease2019

    • Author(s)
      Nojiri Takahiro、Kurano Makoto、Araki Osamu、Nakawatari Kazuki、Nishikawa Masako、Shimamoto Satoshi、Igarashi Koji、Kano Kuniyuki、Aoki Junken、Kihara Shinji、Murakami Masami、Yatomi Yutaka
    • Journal Title

      Endocrine Journal

      Volume: 66 Issue: 5 Pages: 409-422

    • DOI

      10.1507/endocrj.EJ18-0451

    • NAID

      130007655267

    • ISSN
      0918-8959, 1348-4540
    • Related Report
      2019 Annual Research Report 2018 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Serum GM3(d18:1-16:0) and GM3(d18:1-24:1) levels may be associated with lymphoma: An exploratory study with haematological diseases.2019

    • Author(s)
      Nishikawa M, Kurano M, Nitta T, Kanoh H, Inokuchi JI, Yatomi Y.
    • Journal Title

      Sci Rep.

      Volume: 19 Issue: 1 Pages: 6308-6308

    • DOI

      10.1038/s41598-019-42817-3

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Lysophosphatidic acids and their substrate lysophospholipids in cerebrospinal fluid as objective biomarkers for evaluating the severity of lumbar spinal stenosis2019

    • Author(s)
      Hayakawa Kentaro、Kurano Makoto、Ohya Junichi、Oichi Takeshi、Kano Kuniyuki、Nishikawa Masako、Uranbileg Baasanjav、Kuwajima Ken、Sumitani Masahiko、Tanaka Sakae、Aoki Junken、Yatomi Yutaka、Chikuda Hirotaka
    • Journal Title

      Scientific Reports

      Volume: 9 Issue: 1 Pages: 9144-9144

    • DOI

      10.1038/s41598-019-45742-7

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Evaluation of Lysophospholipid Measurement in Cerebrospinal Fluid Samples using Liquid Chromatography-Tandem Mass Spectrometry.2019

    • Author(s)
      Morita Y, Kurano M, Sakai E, Nishikawa M, Sawabe M, Aoki J, Yatomi Y.
    • Journal Title

      Lipids.

      Volume: 54 Issue: 8 Pages: 487-500

    • DOI

      10.1002/lipd.12175

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Redox state of albumin affects its lipid mediator binding characteristics.2019

    • Author(s)
      Kurano M, Yasukawa K, Ikeda H, Aoki J, Yatomi Y.
    • Journal Title

      Free Radic Res.

      Volume: 53 Issue: 8 Pages: 892-900

    • DOI

      10.1080/10715762.2019.1641603

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Serum phosphatidylserine-specific phospholipase A1 as a novel biomarker for monitoring systemic lupus erythematosus disease activity.2019

    • Author(s)
      Sawada T, Kurano M, Shirai H, Iwasaki Y, Tahara K, Hayashi H, Igarashi K, Fujio K, Aoki J, Yatomi Y.
    • Journal Title

      Int J Rheum Dis

      Volume: 22 Issue: 11 Pages: 2059-2066

    • DOI

      10.1111/1756-185x.13689

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Alteration of the lysophosphatidic acid and its precursor lysophosphatidylcholine levels in spinal cord stenosis: A study using a rat cauda equina compression model2019

    • Author(s)
      Uranbileg B, Ito N, Kurano M, Saigusa D, Saito R, Uruno A, Kano K, Ikeda H, Yamada Y, Sumitani M, Sekiguchi M, Aoki J, Yatomi Y.
    • Journal Title

      Scientific reports

      Volume: 9 Issue: 1 Pages: 16578-16578

    • DOI

      10.1038/s41598-019-52999-5

    • URL

      https://pure.teikyo.jp/en/publications/35fd44a1-252a-4f28-a3e0-48245ce26103

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Regulation of plasma glycero-lysophospholipid levels by lipoprotein metabolism2019

    • Author(s)
      Kurano M, Kano K, Hara M, Tsukamoto K, Aoki J, Yatomi Y.
    • Journal Title

      Biochem J

      Volume: 476 Issue: 23 Pages: 3565

    • DOI

      10.1042/bcj20190498

    • URL

      https://localhost/en/publications/6f85f089-b7ac-4462-949b-c623247c1ea1

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Prostaglandin E(2) (PGE(2))-EP2signaling negatively regulates murine atopic dermatitis-like skin inflammation by suppressing thymic stromal lymphopoietin expression.2019

    • Author(s)
      Sawada Y, Honda T, Nakamizo S, Nakajima S, Nonomura Y, Otsuka A, Egawa G, Yoshimoto T, Nakamura M, Narumiya S, Kabashima K.
    • Journal Title

      J Allergy Clin Immunol

      Volume: 144(5) Issue: 5 Pages: 1265-1273

    • DOI

      10.1016/j.jaci.2019.06.036

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Murine neonatal skin mast cells are phenotypically immature and minimally sensitized with transplacentally transferred IgE.2019

    • Author(s)
      Honda Y, Ono S, Honda T, Kataoka TR, Egawa G, Kitoh A, Otsuka A, Nakajima S, Nomura T, Dainichi T, Kabashima K.
    • Journal Title

      J Allergy Clin Immunol. 2019

      Volume: 144(2) Issue: 2 Pages: 617-620

    • DOI

      10.1016/j.jaci.2019.05.011

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Dietary coconut oil ameliorates skin contact hypersensitivity through mead acid production in mice2019

    • Author(s)
      Tiwari Prabha、Nagatake Takahiro、Hirata So‐ichiro、Sawane Kento、Saika Azusa、Shibata Yuki、Morimoto Sakiko、Honda Tetsuya、Adachi Jun、Abe Yuichi、Isoyama Junko、Tomonaga Takeshi、Kiyono Hiroshi、Kabashima Kenji、Kunisawa Jun
    • Journal Title

      Allergy

      Volume: NA Issue: 8 Pages: 1522-1532

    • DOI

      10.1111/all.13762

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Apolipoprotein M suppresses the phenotypes of IgA nephropathy in hyper-IgA mice2019

    • Author(s)
      Kurano Makoto、Tsuneyama Koichi、Morimoto Yuki、Nishikawa Masako、Yatomi Yutaka
    • Journal Title

      The FASEB Journal

      Volume: 33 Issue: 4 Pages: 5181-5195

    • DOI

      10.1096/fj.201801748r

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Autotaxin and soluble IL-2 receptor concentrations in cerebrospinal fluids are useful for the diagnosis of central nervous system invasion caused by haematological malignancies2019

    • Author(s)
      Shimura Takuya、Kurano Makoto、Morita Yoshifumi、Yoshikawa Naoyuki、Nishikawa Masako、Igarashi Koji、Shimamoto Satoshi、Aoki Junken、Yatomi Yutaka
    • Journal Title

      Annals of Clinical Biochemistry: International Journal of Laboratory Medicine

      Volume: 56 Issue: 2 Pages: 240-246

    • DOI

      10.1177/0004563218818197

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Lysophospholipids in laboratory medicine2018

    • Author(s)
      YATOMI Yutaka、KURANO Makoto、IKEDA Hitoshi、IGARASHI Koji、KANO Kuniyuki、AOKI Junken
    • Journal Title

      Proceedings of the Japan Academy, Series B

      Volume: 94 Issue: 10 Pages: 373-389

    • DOI

      10.2183/pjab.94.025

    • NAID

      130007529097

    • ISSN
      0386-2208, 1349-2896
    • Year and Date
      2018-12-11
    • Related Report
      2018 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Lysophosphatidic acid is associated with neuropathic pain intensity in humans: An exploratory study2018

    • Author(s)
      Kuwajima Ken、Sumitani Masahiko、Kurano Makoto、Kano Kuniyuki、Nishikawa Masako、Uranbileg Baasanjav、Tsuchida Rikuhei、Ogata Toru、Aoki Junken、Yatomi Yutaka、Yamada Yoshitsugu
    • Journal Title

      PLOS ONE

      Volume: 13 Issue: 11 Pages: 0207310-0207310

    • DOI

      10.1371/journal.pone.0207310

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Dihydro-sphingosine 1-phosphate interacts with carrier proteins in a manner distinct from that of sphingosine 1-phosphate2018

    • Author(s)
      Mishima Yuko、Kurano Makoto、Kobayashi Tamaki、Nishikawa Masako、Ohkawa Ryunosuke、Tozuka Minoru、Yatomi Yutaka
    • Journal Title

      Bioscience Reports

      Volume: 38 Issue: 5

    • DOI

      10.1042/bsr20181288

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Regulation of the metabolism of apolipoprotein M and sphingosine 1-phosphate by hepatic PPARγ activity2018

    • Author(s)
      Kurano Makoto、Ikeda Hitoshi、Iso-O Naoyuki、Hara Masumi、Tsukamoto Kazuhisa、Yatomi Yutaka
    • Journal Title

      Biochemical Journal

      Volume: 475 Issue: 12 Pages: 2009

    • DOI

      10.1042/bcj20180052

    • URL

      https://pure.teikyo.jp/en/publications/f7c4b4b0-8d2f-4509-8584-16709d14be2e

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Apolipoprotein M Protects Lipopolysaccharide-Treated Mice from Death and Organ Injury.2018

    • Author(s)
      Kurano M, Tsuneyama K, Morimoto Y, Shimizu T, Jona M, Kassai H, Nakao K, Aiba A, Yatomi Y
    • Journal Title

      Thromb Haemost.

      Volume: 印刷中 Issue: 06 Pages: 1021-1035

    • DOI

      10.1055/s-0038-1641750

    • Related Report
      2018 Annual Research Report 2017 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Measurement of plasma choline in acute coronary syndrome: importance of suitable sampling conditions for this assay2018

    • Author(s)
      Ohkawa Ryunosuke、Kurano Makoto、Sakai Noboru、Kishimoto Tatsuya、Nojiri Takahiro、Igarashi Koji、Hosogaya Shigemi、Ozaki Yukio、Dohi Tomotaka、Miyauchi Katsumi、Daida Hiroyuki、Aoki Junken、Okubo Shigeo、Ikeda Hitoshi、Tozuka Minoru、Yatomi Yutaka
    • Journal Title

      Scientific Reports

      Volume: 8 Issue: 1 Pages: 1-12

    • DOI

      10.1038/s41598-018-23009-x

    • Related Report
      2018 Annual Research Report 2017 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Resolvin E1 attenuates murine psoriatic dermatitis2018

    • Author(s)
      Sawada Yu、Honda Tetsuya、Nakamizo Satoshi、Otsuka Atsushi、Ogawa Narihito、Kobayashi Yuichi、Nakamura Motonobu、Kabashima Kenji
    • Journal Title

      Scientific Reports

      Volume: 8 Issue: 1 Pages: 1-9

    • DOI

      10.1038/s41598-018-30373-1

    • NAID

      120006539571

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Association between serum autotaxin or phosphatidylserine-specific phospholipase A1 levels and melanoma2018

    • Author(s)
      Kurano Makoto、Miyagaki Tomomitsu、Miyagawa Takuya、Igarashi Koji、Shimamoto Satoshi、Ikeda Hitoshi、Aoki Junken、Sato Shinichi、Yatomi Yutaka
    • Journal Title

      The Journal of Dermatology

      Volume: - Issue: 5 Pages: 571-579

    • DOI

      10.1111/1346-8138.14278

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Sitosterol prevents obesity-related chronic inflammation2018

    • Author(s)
      Kurano Makoto、Hasegawa Koji、Kunimi Motoei、Hara Masumi、Yatomi Yutaka、Teramoto Tamio、Tsukamoto Kazuhisa
    • Journal Title

      Biochim Biophys Acta.

      Volume: 1863 Issue: 2 Pages: 191-198

    • DOI

      10.1016/j.bbalip.2017.12.004

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Sphingosine 1-Phosphate and Atherosclerosis2018

    • Author(s)
      Kurano Makoto、Yatomi Yutaka
    • Journal Title

      Journal of Atherosclerosis and Thrombosis

      Volume: 25 Issue: 1 Pages: 16-26

    • DOI

      10.5551/jat.RV17010

    • NAID

      130006301107

    • ISSN
      1340-3478, 1880-3873
    • Related Report
      2017 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Thromboxane A2 facilitates IL-17A production from Vγ4+ γδ T cells and promotes psoriatic dermatitis in mice.2018

    • Author(s)
      Ueharaguchi Y, Honda T, Kusuba N, Hanakawa S, Adachi A, Sawada Y, Otsuka A, Kitoh A, Dainichi T, Egawa G, Nakashima C, Nakajima S, Murata T, Ono S, Arita M, Narumiya S, Miyachi M, Kabashima K.
    • Journal Title

      J Allergy Clin Immunol

      Volume: -

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Multipolarity of cytokine axes in the pathogenesis of atopic dermatitis in terms of age, race, species, disease stage and biomarkers2018

    • Author(s)
      Nomura Takashi、Honda Tetsuya、Kabashima Kenji
    • Journal Title

      International Immunology

      Volume: - Issue: 9 Pages: 419-428

    • DOI

      10.1093/intimm/dxy015

    • Related Report
      2017 Annual Research Report
  • [Journal Article] Evidence Suggests Sphingosine 1-Phosphate Might Be Actively Generated, Degraded, and Transported to Extracellular Spaces With Increased S1P <sub>2</sub> and S1P <sub>3</sub> Expression in Colon Cancer2017

    • Author(s)
      Uranbileg B, Nishikawa T, Ikeda H, Kurano M, Sato M, Saigusa D, Aoki J, Watanabe T, Yatomi Y.
    • Journal Title

      Clin Colorectal Cancer.

      Volume: 17 Issue: 2 Pages: 30369-9

    • DOI

      10.1016/j.clcc.2017.11.004

    • URL

      https://localhost/en/publications/d098fb62-2329-4603-ac82-13a91a0bc0b5

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Involvement of Band3 in the efflux of sphingosine 1-phosphate from erythrocytes2017

    • Author(s)
      Kurano M, Nishikawa M, Kuma H, Jona M, Yatomi Y.
    • Journal Title

      PLOS ONE

      Volume: 12 Issue: 5 Pages: e0177543-e0177543

    • DOI

      10.1371/journal.pone.0177543

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Analysis of glycero-lysophospholipids in gastric cancerous ascites.2017

    • Author(s)
      Emoto, S., Kurano, M., Kano, K., Matsusaki, K., Yamashita, H., Nishikawa, M., Igarashi, K., Ikeda, H., Aoki, J., Kitayama, J., and Yatomi, Y.
    • Journal Title

      J. Lipid Res

      Volume: 58 Issue: 4 Pages: 763-771

    • DOI

      10.1194/jlr.p072090

    • Related Report
      2017 Annual Research Report 2016 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] High fat diet exacerbates murine psoriatic dermatitis by increasing the number of IL-17-producing γδ T cells2017

    • Author(s)
      Nakamizo Satoshi、Honda Tetsuya、Adachi Akimasa、Nagatake Takahiro、Kunisawa Jun、Kitoh Akihiko、Otsuka Atsushi、Dainichi Teruki、Nomura Takashi、Ginhoux Florent、Ikuta Koichi、Egawa Gyohei、Kabashima Kenji
    • Journal Title

      Scientific Reports

      Volume: 7 Issue: 1 Pages: 999-999

    • DOI

      10.1038/s41598-017-14292-1

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] 17,18-EpETE-GPR40 axis ameliorates contact hypersensitivity by inhibiting neutrophil mobility in mice and cynomolgus macaques2017

    • Author(s)
      Nagatake T, Shiogama Y, Inoue A, Kikuta J, Honda T, Tiwari P, Kishi T, Yanagisawa A, Isobe Y, Matsumoto N, Shimojou M, Morimoto S, Suzuki H, Hirata S, Steneberg P, Edlund H, Aoki J, Arita M, Kiyono H, Yasutomi Y, Ishii M, Kabashima K, Kunisawa J
    • Journal Title

      Journal of Allergy and Clinical Immunology

      Volume: S0091-6749 Issue: 2 Pages: 32949-32944

    • DOI

      10.1016/j.jaci.2017.09.053

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Involvement of Cholesteryl Ester Transfer Protein in the Shift of Sphingosine 1-Phosphate Among Lipoproteins and in the Modulation of its Functions.2017

    • Author(s)
      Kurano, M., Hara, M., Ikeda, H., Tsukamoto, K., and Yatomi, Y
    • Journal Title

      Arterioscler. Thromb. Vasc. Biol.

      Volume: 37 Issue: 3 Pages: 506-514

    • DOI

      10.1161/atvbaha.116.308692

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Different Origins of Lysophospholipid Mediators between Coronary and Peripheral Arteries in Acute Coronary Syndrome.2017

    • Author(s)
      Kurano, M., Kano, K., Dohi, T., Matsumoto, H., Igarashi, K., Nishikawa, M., Ohkawa, R., Ikeda, H., Miyauchi, K., Daida, H., Aoki, J., and Yatomi, Y.
    • Journal Title

      J. Lipid Res.

      Volume: 58 Issue: 2 Pages: 433-442

    • DOI

      10.1194/jlr.p071803

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Vehicle-dependent Effects of Sphingosine 1-phosphate on Plasminogen Activator Inhibitor-1 Expression2017

    • Author(s)
      Takahashi, C., Kurano, M., Nishikawa, M., Kano, K., Dohi, T., Miyauchi, K., Daida, H., Shimizu, T., Aoki, J., and Yatomi, Y.
    • Journal Title

      Journal of Atherosclerosis and Thrombosis

      Volume: 24 Issue: 9 Pages: 954-969

    • DOI

      10.5551/jat.37663

    • NAID

      130006038432

    • ISSN
      1340-3478, 1880-3873
    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] RIPK3 controls keratinocyte activation in a necroptosis-independent manner and promotes psoriatic dermatitis in mice2017

    • Author(s)
      Tetsuya Honda, Osamu Yamamoto MD, Yu Sawada, Gyohei Egawa, Akihiko Kitoh, Atsushi Otsuka, Teruki Dainichi, Saeko Nakajima, Yoshiki Miyachi, Kenji Kabashima
    • Journal Title

      Journal of Allergy and Clinical Immunology

      Volume: 5 Issue: 2 Pages: 619-622.e6

    • DOI

      10.1016/j.jaci.2017.02.027

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] Higher LPA2 and LPA6 mRNA Levels in Hepatocellular Carcinoma Are Associated with Poorer Differentiation, Microvascular Invasion and Earlier Recurrence with Higher Serum Autotaxin Levels.2016

    • Author(s)
      Enooku K, Uranbileg B, Ikeda H, Kurano M, Sato M, Kudo H, Maki H, Koike K, Hasegawa K, Kokudo N, Yatomi Y.
    • Journal Title

      PLoS One

      Volume: 11 Issue: 9 Pages: e0161825-e0161825

    • DOI

      10.1371/journal.pone.0161825

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Resveratrol exerts a biphasic effect on apolipoprotein M2016

    • Author(s)
      Kurano M, Hara M, Nojiri T, Ikeda H, Tsukamoto K, Yatomi Y.
    • Journal Title

      Br J Pharmacol

      Volume: 173 Issue: 1 Pages: 222

    • DOI

      10.1111/bph.13360

    • URL

      https://localhost/en/publications/493cbee5-50a6-452c-9935-d050da3345cf

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Regulation of the lysophosphatidylserine and sphingosine 1-phosphate levels in autologous whole blood by the pre-storage leukocyte reduction2016

    • Author(s)
      Nagura, Y., Tsuno, NH., Kano, K., Inoue, A., Aoki, J., Hirowatari, Y., Kaneko, M., Kurano, M., Matsuhashi, M., Ohkawa, R., Tozuka, M., Yatomi, Y., and Okazaki, H.
    • Journal Title

      Transfus. Med.

      Volume: 26 Issue: 5 Pages: 365-372

    • DOI

      10.1111/tme.12326

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Sphingosine kinase-1, S1P transporter spinster homolog 2 and S1P2 mRNA expressions are increased in liver with advanced fibrosis in human2016

    • Author(s)
      Sato M, Ikeda H, Uranbileg B, Kurano M, Saigusa D, Aoki J, Maki H, Kudo H, Hasegawa K, Kokudo N, Yatomi Y.
    • Journal Title

      Sci Rep.

      Volume: 6 Issue: 1 Pages: 32119-32119

    • DOI

      10.1038/srep32119

    • URL

      https://pure.teikyo.jp/en/publications/6c646c5a-fdef-4a82-b6b9-d05519c49ef9

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Serum Autotaxin Levels Are Associated with Proteinuria and Kidney Lesions in Japanese Type 2 Diabetic Patients with Biopsy-proven Diabetic Nephropathy2016

    • Author(s)
      Shimizu M, Furuichi K, Toyama T, Yamahana J, Ohkawa R, Igarashi K, Aoki J, Kaneko S, Yatomi Y, Wada T
    • Journal Title

      Internal Medicine

      Volume: 55 Issue: 3 Pages: 215-221

    • DOI

      10.2169/internalmedicine.55.5473

    • NAID

      130005122604

    • ISSN
      0918-2918, 1349-7235
    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Increased mRNA Levels of Sphingosine Kinases and S1P Lyase and Reduced Levels of S1P Were Observed in Hepatocellular Carcinoma in Association with Poorer Differentiation and Earlier Recurrence2016

    • Author(s)
      Uranbileg B, Ikeda H, Kurano M, Enooku K, Sato M, Saigusa D, Aoki J, Ishizawa T, Hasegawa K, Kokudo N, Yatomi Y.
    • Journal Title

      PLoS One

      Volume: 11 Issue: 2 Pages: e0149462-e0149462

    • DOI

      10.1371/journal.pone.0149462

    • URL

      https://localhost/en/publications/62fb74ec-2e4f-4012-8c4f-752054cad4ee

    • Related Report
      2016 Annual Research Report 2015 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Prostanoids in allergy2015

    • Author(s)
      Honda T, Kabashima K.
    • Journal Title

      Allergology International

      Volume: 64 Issue: 1 Pages: 11-16

    • DOI

      10.1016/j.alit.2014.08.002

    • NAID

      130004873121

    • ISSN
      1323-8930, 1440-1592
    • Related Report
      2015 Annual Research Report
    • Peer Reviewed
  • [Presentation] Apolipoprotein M and sphingosine 1-phosphate prevents the progression of diabetic nephropathy2019

    • Author(s)
      Kurano M and Yatomi Y
    • Organizer
      60th International Conference on the Bioscience of Lipids
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Involvement of LPA and its precursor, LPC in spinal cord stenosis: studies using rat models2019

    • Author(s)
      59.Uranbileg B, Ito N, Kurano M, Saigusa D, Kano K, Ikeda H, Yamada Y, Sumitani M, Sekiguchi M, Aoki J, and Yatomi Y
    • Organizer
      60th International Conference on the Bioscience of Lipids
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Lysophospholipids: from bench to clinic & from clinic to bench2019

    • Author(s)
      Yatomi Y and Kurano M
    • Organizer
      60th International Conference on the Bioscience of Lipids
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Involvement of dysregulation of apolipoproteinM, a sphingosine 1-phosphate carrier, in human diseases2019

    • Author(s)
      Yatomi Y and Kurano M
    • Organizer
      16th International Conference on Bioactive Lipids in Cancer, Inflammation and Related Diseases
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] ヒトサンプルを用いた生理活性脂質測定系によるヒト疾患病態の解明と臨床検査への応用2019

    • Author(s)
      蔵野 信, 森田 賢史, 坂井 英里, Uranbileg B, 青木 淳賢, 矢冨 裕
    • Organizer
      第66回日本臨床検査医学会学術集会
    • Related Report
      2019 Annual Research Report
    • Invited
  • [Presentation] Possible involvement of PS-PLA1 and lysophosphatidylserine receptor 1 in hepatocellular carcinoma2019

    • Author(s)
      Uranbileg B, 蔵野 信, 佐藤 雅哉, 池田 均, 矢冨 裕
    • Organizer
      第66回日本臨床検査医学会学術集会
    • Related Report
      2019 Annual Research Report
  • [Presentation] Involvement of LPA and its precursor, LPC in spinal cord stenosis: studies using a rat CEC model2019

    • Author(s)
      Uranbileg B, Ito N, Kurano M, Ikeda H, and Yatomi Y
    • Organizer
      第59回日本臨床化学会年次学術集会
    • Related Report
      2019 Annual Research Report
  • [Presentation] リポ蛋白の酸化によるグリセロリゾリン脂質の変化は、酸化リポ蛋白の催炎症作用に寄与する2019

    • Author(s)
      蔵野 信, 矢冨 裕
    • Organizer
      第59回日本臨床化学会年次学術集会
    • Related Report
      2019 Annual Research Report
  • [Presentation] 髄液中リゾホスファチジン酸、リゾホスファチジルコリンは客観的疼痛マーカーである2019

    • Author(s)
      蔵野 信, 住谷 昌彦, 坂井 英里, 可野 邦行, 青木 淳賢, 矢冨 裕
    • Organizer
      第44回日本医用マススペクトル学会年会
    • Related Report
      2019 Annual Research Report
  • [Presentation] グリセロリゾリン脂質の網羅的測定のための採血管の開発2019

    • Author(s)
      吉川 直之, 蔵野 信, 矢冨 裕
    • Organizer
      第66回日本臨床検査医学会学術集会
    • Related Report
      2019 Annual Research Report
  • [Presentation] 大腸菌におけるリゾリン脂質-ジアリルリン脂質系の役割についての検討2019

    • Author(s)
      上市 裕子, 蔵野 信, 斎藤 良一, 矢冨 裕
    • Organizer
      第66回日本臨床検査医学会学術集会
    • Related Report
      2019 Annual Research Report
  • [Presentation] S1Pリアーゼの肝再生における役割の検討2019

    • Author(s)
      影山 裕子, Uranbileg B, 蔵野 信, 池田 均, 矢冨 裕
    • Organizer
      第66回日本臨床検査医学会学術集会
    • Related Report
      2019 Annual Research Report
  • [Presentation] 健常者血漿・血清エクソソーム中のリゾリン脂質成分の解析2019

    • Author(s)
      志村 拓也, 蔵野 信, 矢冨 裕
    • Organizer
      第66回日本臨床検査医学会学術集会
    • Related Report
      2019 Annual Research Report
  • [Presentation] 尿中セラミド一斉定量系の確立とその測定意義2019

    • Author(s)
      森田 賢史, 蔵野 信, 坂井 英里, 矢冨 裕
    • Organizer
      第66回日本臨床検査医学会学術集会
    • Related Report
      2019 Annual Research Report
  • [Presentation] Lipids, cell subsets, and cell dynamics in the skin2019

    • Author(s)
      Honda T
    • Organizer
      The 44th Annual Meeting of the Japanese Society for Investigative Dermatology
    • Related Report
      2019 Annual Research Report
  • [Presentation] 食事由来脂質とその代謝物による乾癬病態制御2019

    • Author(s)
      本田哲也
    • Organizer
      第118回日本皮膚科学会総会
    • Related Report
      2019 Annual Research Report
  • [Presentation] アトピー性皮膚炎の免疫学的病態2018

    • Author(s)
      本田 哲也
    • Organizer
      第67回日本アレルギー学会
    • Related Report
      2018 Annual Research Report
  • [Presentation] 乾癬病態形成における脂肪酸の役割2018

    • Author(s)
      本田 哲也
    • Organizer
      第33回日本乾癬学会
    • Related Report
      2018 Annual Research Report
  • [Presentation] 高脂肪食と乾癬・皮膚免疫2018

    • Author(s)
      本田 哲也
    • Organizer
      第33回日本乾癬学会
    • Related Report
      2018 Annual Research Report
  • [Presentation] Immune responses of the skin to allergens2018

    • Author(s)
      Tetsuya Honda
    • Organizer
      AAAAI/WAO Joint Congress 2018 3.2-3.5
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 糖代謝異常におけるスフィンゴシン1-リン酸/アポ蛋白M軸の役割2018

    • Author(s)
      蔵野 信,塚本 和久,清水 知,矢冨 裕
    • Organizer
      第60回 日本脂質生化学会
    • Related Report
      2018 Annual Research Report
  • [Presentation] 肝臓NPC1L1は血漿スフィンゴシン1-リン酸を増加させる2018

    • Author(s)
      蔵野 信,塚本 和久,原 眞純,矢冨 裕
    • Organizer
      第50回 日本動脈硬化学会総会・学術集会
    • Related Report
      2018 Annual Research Report
  • [Presentation] 新規生理活性脂質リゾホスファチジルセリンの炎症への関与:分子種による作用の相違2018

    • Author(s)
      蔵野 信,矢冨 裕
    • Organizer
      第58回 日本臨床化学会年次学術集会
    • Related Report
      2018 Annual Research Report
  • [Presentation] アポ蛋白M/スフィンゴシン1-リン酸軸の糖尿病性腎症における役割2018

    • Author(s)
      蔵野 信,塚本 和久,原 眞純,矢冨 裕.
    • Organizer
      第33回 日本糖尿病合併症学会学術集会
    • Related Report
      2018 Annual Research Report
  • [Presentation] 中枢神経系のアポ蛋白Mの役割2018

    • Author(s)
      蔵野 信,常山 幸一,矢冨 裕
    • Organizer
      第65回 日本臨床検査医学会学術集会
    • Related Report
      2018 Annual Research Report
  • [Presentation] 造血器腫瘍の髄膜浸潤におけるATX/LPA axisの関与 臨床検体を用いた検討2018

    • Author(s)
      志村 拓也,蔵野 信,吉川 直之,森田 賢史,田中 雅美,西川 真子,常名 政弘,五十嵐 浩二,矢冨 裕
    • Organizer
      第19回 日本検査血液学会学術集会
    • Related Report
      2018 Annual Research Report
  • [Presentation] 髄液検体におけるsIL-2RとATX 造血器腫瘍の中枢神経浸潤バイオマーカーとしての有用性2018

    • Author(s)
      志村 拓也,蔵野 信,森田 賢史,西川 真子,吉川 直之,田中 雅美,下坂 浩則,常名 政弘,島本 怜史,五十嵐 浩二,矢冨 裕
    • Organizer
      第65回 日本臨床検査医学会学術集会
    • Related Report
      2018 Annual Research Report
  • [Presentation] バセドウ病におけるPS-PLA1の新規バイオマーカーとしての有用性に関する検討2018

    • Author(s)
      中渡一 貴,蔵野 信,野尻 卓宏,島本 怜史,五十嵐 浩二,矢冨 裕
    • Organizer
      第65回 日本臨床検査医学会学術集会
    • Related Report
      2018 Annual Research Report
  • [Presentation] アラキドン酸またはDHA添加時の脂質メディエーターの解析:肝癌細胞株および大腸癌細胞株における検討2018

    • Author(s)
      西川 尚子,蔵野 信,Baasanjav Uranbileg,池田 均,矢冨 裕
    • Organizer
      第65回 日本臨床検査医学会学術集会
    • Related Report
      2018 Annual Research Report
  • [Presentation] 血清GM3分子種d18:1-16:0,d18:1-24:1は,リンパ腫の新規バイオマーカーである2018

    • Author(s)
      西川 真子,蔵野 信,新田 昴大,狩野 裕孝,井ノ口 仁一,矢冨 裕
    • Organizer
      第80回 日本血液学会学術集会
    • Related Report
      2018 Annual Research Report
  • [Presentation] 癌性髄膜炎における髄液中リゾリン脂質の測定意義2018

    • Author(s)
      森田 賢史,蔵野信,矢冨裕
    • Organizer
      第65回 日本臨床検査医学会学術集会
    • Related Report
      2018 Annual Research Report
  • [Presentation] The Status of the Sphingolipid Metabolism in Rat Cauda Equina Compression Model.2018

    • Author(s)
      Uranbileg, B., Hasegawa, K., Ito, N., Kurano, M., Saigusa, D., Kano, K., Ikeda, H., Sumitani, M., Aoki, J., and Yatomi, Y.
    • Organizer
      第58回 日本臨床化学会年次学術集会
    • Related Report
      2018 Annual Research Report
  • [Presentation] Possible involvement of Phosphatidylserine-LysoPS Axis in the Pathophysiology of Carcinogenesis.2018

    • Author(s)
      Uranbileg, B., Kurano, M., Nishikawa, T., Sato, M., IkedaH., and Yatomi, Y.
    • Organizer
      第65回 日本臨床検査医学会学術集会
    • Related Report
      2018 Annual Research Report
  • [Presentation] The importance of S1P lyase in the pathophysiology of hepatocellular carcinoma and colon cancer.2018

    • Author(s)
      Uranbileg, B., Ikeda, H., Kurano, M., Saigusa, D., Kano, K., Aoki, J., and Yatomi, Y.
    • Organizer
      The 15th Congress of the Asian Society for Clinical Pathology and Laboratory Medicine (ASCPaLM)
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 植物ステロール吸収促進は,肥満による慢性炎症を抑制する2017

    • Author(s)
      蔵野 信,長谷川 浩司,国見 基瑩,原 眞純,矢冨 裕,塚本 和久
    • Organizer
      第60回 日本糖尿病学会年次学術集会
    • Related Report
      2017 Annual Research Report
  • [Presentation] K562細胞は,リゾホスファチジルセリンにより巨核球への分化誘導が修飾される2017

    • Author(s)
      蔵野 信,西川 真子,矢冨 裕
    • Organizer
      第39回 日本血栓止血学会学術集会
    • Related Report
      2017 Annual Research Report
  • [Presentation] リポ蛋白代謝・修飾によるグリセロリゾリン脂質の変動2017

    • Author(s)
      蔵野 信,可野 邦行,小林 玉宜,青木 淳賢,矢冨 裕
    • Organizer
      第59回 日本脂質生化学会
    • Related Report
      2017 Annual Research Report
  • [Presentation] 酸化,糖化によるリポ蛋白中のリゾリン脂質変化とその意義2017

    • Author(s)
      蔵野 信,可野 邦之,青木 淳賢,矢冨 裕
    • Organizer
      第32回 日本糖尿病合併症学会
    • Related Report
      2017 Annual Research Report
  • [Presentation] ホスファチジルセリン特異的ホスホリパーゼA1,リゾホスファチジルセリンの糖尿病の病態生理への関与の解明2017

    • Author(s)
      蔵野 信,五十嵐 浩二,池田 均,塚本 和久,矢冨 裕
    • Organizer
      第64回 日本臨床検査医学会学術集会
    • Related Report
      2017 Annual Research Report
  • [Presentation] Glycation of Apolipoprotein M attenuated its capacity to bind Sphingosine-1 Phosphate.2017

    • Author(s)
      Kobayashi, T., Kurano, M., Mishima, Y., Nojiri, T., Ohkawa, R., Tozuka, M., and Yatomi, Y.
    • Organizer
      The 29th World Congress of World Association of Societies of Pathology and Laboratory Medicine (WASPaLM)
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Possible involvement of glycero-lysophopholipids in the pathogenesis of ACS, revealed by an LC/MS technique.2017

    • Author(s)
      Kurano, M., Kano, K., Dohi, T., Ikeda, H., Aoki, J., and Yatomi Y
    • Organizer
      The 29th World Congress of World Association of Societies of Pathology and Laboratory Medicine (WASPaLM).
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Difference between sphingosine 1-phosphate and dihydrosphingosine 1-phosphate in their preference to HDL or albumin.2017

    • Author(s)
      Mishima,Y., Kurano,M., Kobayahsi,T., Nishikawa,M., Ohkawa,R., Tozuka,M.,Yatomi,Y
    • Organizer
      The 29th World Congress of World Association of Societies of Pathology and Laboratory Medicine (WASPaLM).
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Clinical Significance of Autotaxin in the field of Hematology.2017

    • Author(s)
      Nishikawa, M., Kurano, M., Shimamoto, S., Igarashi, K., Yatomi, Y.
    • Organizer
      The 29th World Congress of World Association of Societies of Pathology and Laboratory Medicine (WASPaLM).
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Serum autotaxin is increased and correlated with thyroid hormone in Graves' disease.2017

    • Author(s)
      Nojiri, T., Kurano, M., Nakawatari, K. Shimamoto,S., Igarashi, K., Sone, S., Ikeda, H., and Yatomi, Y.
    • Organizer
      The 29th World Congress of World Association of Societies of Pathology and Laboratory Medicine (WASPaLM).
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] S1P is actively metabolized and transported to extracellular spaces with increased receptors expression in colon cancer.2017

    • Author(s)
      Uranbileg, B., Nishikawa,T., Ikeda, H., Kurano, M., Sato, M., Saigusa, D., Aoki, J., Watanabe, T., and Yatomi, Y
    • Organizer
      The 29th World Congress of World Association of Societies of Pathology and Laboratory Medicine (WASPaLM).
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Identification of resolvin E1, an omega-3 poly-unsaturated fatty acids-derived lipid mediator, as an inhibitor for psoriatic dermatitis.2017

    • Author(s)
      本田 哲也
    • Organizer
      第42回日本研究皮膚科学会
    • Related Report
      2017 Annual Research Report
  • [Presentation] リポクオリティに着目した新しい臨床検査の可能性2017

    • Author(s)
      矢冨 裕
    • Organizer
      第42回日本医用マススペクトル学会年会
    • Related Report
      2017 Annual Research Report
    • Invited
  • [Presentation] Development of clinical laboratory tests from the viewpoint of lipoquality2017

    • Author(s)
      Yatomi Y
    • Organizer
      International Conference on Lipoquality 2017
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Diet in the pathogenesis of psoriasis: a review of recent progress2016

    • Author(s)
      本田哲也
    • Organizer
      第41回日本研究皮膚科学会
    • Place of Presentation
      仙台
    • Year and Date
      2016-12-09
    • Related Report
      2016 Annual Research Report
    • Invited
  • [Presentation] リコンビナントアポ蛋白Mを利用した多臓器不全に対する新規治療法の開発2016

    • Author(s)
      蔵野 信,矢冨 裕
    • Organizer
      第56回 日本臨床化学会年次学術集会
    • Place of Presentation
      熊本
    • Year and Date
      2016-12-03
    • Related Report
      2016 Annual Research Report
  • [Presentation] Involvement of Lysophosphatidylserine in the Pathophysiology of Hepatocellular Carcinoma2016

    • Author(s)
      Baasanjav Uranbileg, Hitoshi Ikeda, Makoto Kurano, Yutaka Yatomi
    • Organizer
      第56回 日本臨床化学会年次学術集会
    • Place of Presentation
      熊本
    • Year and Date
      2016-12-03
    • Related Report
      2016 Annual Research Report
  • [Presentation] Sphingosine 1-Phosphate Possesses the Carrier-dependent Effects on the Plasminogen Activator Inhibitor 1 Expression in Adipocytes2016

    • Author(s)
      Takahashi, C., Kurano, M., Nishikawa, M., Kano, K., Dohi, T., Miyauchi, K., Daida, H., Shimizu, T., Aoki, J., and Yatomi, Y.
    • Organizer
      AHA Scientific Sessions 2016
    • Place of Presentation
      New Orleans, Louisiana, USA
    • Year and Date
      2016-11-12
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] アポ蛋白Mの抗糖尿病性腎症作用2016

    • Author(s)
      蔵野 信,塚本 和久,矢冨 裕
    • Organizer
      第31回 日本糖尿病合併症学会
    • Place of Presentation
      仙台
    • Year and Date
      2016-10-08
    • Related Report
      2016 Annual Research Report
  • [Presentation] Carrier-dependent Effects of Sphingosine 1-phosphate on Plasminogen Activator Inhibitor-1 Expression in Adipocytes2016

    • Author(s)
      Takahashi, C., Kurano, M., Nishikawa, M., and Yatomi, Y.
    • Organizer
      The 9th Congress of the Asia Pacific Society on Thrombosis and Hemostasis
    • Place of Presentation
      Taipei, Chinese Taipei
    • Year and Date
      2016-10-06
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] IgA腎症におけるスフィンゴシン1-リン酸の役割2016

    • Author(s)
      蔵野 信,矢冨 裕
    • Organizer
      第63回 日本臨床検査医学会学術集会
    • Place of Presentation
      神戸
    • Year and Date
      2016-09-02
    • Related Report
      2016 Annual Research Report
  • [Presentation] Detection and Regulation of Apolipoprotein M in Central Nervous System2016

    • Author(s)
      Hisasue, N., Kurano, M., Morimoto, Y., Tsuneyama, K., Kubota, T., Yatomi, Y.
    • Organizer
      The 32nd World Congress of Biomedical Laboratory Science 2016 IFBLS
    • Place of Presentation
      Kobe, Japan
    • Year and Date
      2016-08-31
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Oxidation and Glycation Modulate HDL Capacity to Carry Sphingosine 1-Phosphate, an Anti-Atherosclerotic Bioactive Lipid2016

    • Author(s)
      Kobayashi, T., Kurano, M., Nojiri, T., Ohkawa, R., Tozuka, M., Okubo, S., and Yatomi, Y.
    • Organizer
      The 32nd World Congress of Biomedical Laboratory Science 2016 IFBLS
    • Place of Presentation
      Kobe, Japan
    • Year and Date
      2016-08-31
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 2型糖尿病患者におけるリゾリン脂質関連蛋白と合併症の関係2016

    • Author(s)
      蔵野 信,清水 知,五十嵐 浩二,原 眞純,塚本 和久,矢冨 裕
    • Organizer
      第48回 日本動脈硬化学会学術集会
    • Place of Presentation
      東京
    • Year and Date
      2016-07-15
    • Related Report
      2016 Annual Research Report
  • [Presentation] アポ蛋白Mを用いた播種性血管内凝固症候群,多臓器不全の新規治療法の開発2016

    • Author(s)
      蔵野 信,常山 幸一,常名 政弘,矢冨 裕
    • Organizer
      第38回 日本血栓止血学会学術集会
    • Place of Presentation
      奈良
    • Year and Date
      2016-06-18
    • Related Report
      2016 Annual Research Report
  • [Presentation] The Laboratory Medicine of Lysophospholipids2016

    • Author(s)
      Yatomi, Y., Kurano, M., Ikeda, H., and Aoki, J.
    • Organizer
      Korea-Japan Bioactive Lipid Joint Symposium
    • Place of Presentation
      Jeju Island, South Korea
    • Year and Date
      2016-05-11
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] High fat diet exacerbates psoriatic dermatitis by facilitating IL-17-producing γδT cell accumulation in the skin2016

    • Author(s)
      Tetsuya Honda
    • Organizer
      SID2016 Society of Investigative Dermatology Annual Meeting
    • Place of Presentation
      Scottsdale, USA
    • Year and Date
      2016-05-11
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 糖尿病性腎症におけるアポ蛋白Mの役割2015

    • Author(s)
      蔵野 信,清水 知,矢冨 裕
    • Organizer
      第61回 日本臨床検査医学会学術集会
    • Place of Presentation
      岐阜
    • Year and Date
      2015-11-19
    • Related Report
      2015 Annual Research Report
  • [Presentation] High fat diet exacerbates psoriatic dermatitis by facilitating IL-17-producing gamma delta T cells accumulation in the skin via perivascular adipose tissue2015

    • Author(s)
      中溝聡、本田哲也、椛島健治
    • Organizer
      第14回国際Langerhans細胞ワークショップ
    • Place of Presentation
      京都府京都市左京区 京都市国際交流会館
    • Year and Date
      2015-11-05
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research
  • [Book] 炎症と免疫2017

    • Author(s)
      本田哲也
    • Publisher
      先端医学社
    • Related Report
      2016 Annual Research Report
  • [Remarks] 東京大学医学部附属病院検査部

    • URL

      http://lab-tky.umin.jp/index.html

    • Related Report
      2019 Annual Research Report
  • [Remarks] 東京大学医学部附属病院 検査部ホームページ

    • URL

      http://lab-tky.umin.jp/index.html

    • Related Report
      2018 Annual Research Report
  • [Remarks] 東京大学医学部附属病院 検査部

    • URL

      http://lab-tky.umin.jp

    • Related Report
      2017 Annual Research Report
  • [Remarks] 東京大学大学院医学系研究科 内科学専攻病態診断医学講座 臨床病態検査医学分野

    • URL

      http://lab-tky.umin.jp

    • Related Report
      2016 Annual Research Report
  • [Funded Workshop] International Conference on Lipoquality 20172017

    • Related Report
      2017 Annual Research Report

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Published: 2015-07-02   Modified: 2022-11-04  

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