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Understanding human diseases from the viewpoint of lipoquality

Planned

Project AreaQuality of lipids in biological systems
Project/Area Number 15H05906
Research Category

Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)

Allocation TypeSingle-year Grants
Review Section Biological Sciences
Research InstitutionThe University of Tokyo

Principal Investigator

矢冨 裕  東京大学, 医学部附属病院, 教授 (60200523)

Co-Investigator(Kenkyū-buntansha) 本田 哲也  京都大学, 医学研究科, 講師 (40452338)
Project Period (FY) 2015-06-29 – 2020-03-31
Project Status Granted (Fiscal Year 2019)
Budget Amount *help
¥94,770,000 (Direct Cost: ¥72,900,000、Indirect Cost: ¥21,870,000)
Fiscal Year 2019: ¥18,460,000 (Direct Cost: ¥14,200,000、Indirect Cost: ¥4,260,000)
Fiscal Year 2018: ¥18,590,000 (Direct Cost: ¥14,300,000、Indirect Cost: ¥4,290,000)
Fiscal Year 2017: ¥20,410,000 (Direct Cost: ¥15,700,000、Indirect Cost: ¥4,710,000)
Fiscal Year 2016: ¥20,410,000 (Direct Cost: ¥15,700,000、Indirect Cost: ¥4,710,000)
Fiscal Year 2015: ¥16,900,000 (Direct Cost: ¥13,000,000、Indirect Cost: ¥3,900,000)
Keywordsリポクオリティ / ヒト検体 / 癌 / 皮膚疾患 / 神経障害性疼痛 / 冠動脈疾患 / 皮膚科疾患 / 分子種 / 臨床 / 内科 / 免疫学 / 生理活性 / 脂質 / アレルギー / リゾリン脂質 / プロスタグランジン / 肝癌 / アトピー性皮膚炎 / 乾癬 / 腹膜癌腫症
Outline of Annual Research Achievements

【矢冨グループ】
・急性冠症候群では、血漿中において長鎖不飽和リゾホスファチジン酸(LPA)が、オートタキシン非依存性に増加しており、その産生にマイナーグリセロリゾリン脂質が関与していることを冠動脈・大腿動脈から得た血漿検体を用いた検討にて確認した。また、リポ蛋白質の酸化・糖化、冠動脈疾患の発生母地である糖尿病モデルマウスによるリゾリン脂質、ジアシルリン脂質の変動を確認した。
・肝癌、大腸癌では、癌の進展に重要と想定されているスフィンゴシン1-リン酸(S1P)は、むしろスフィンゴ脂質からグリセロ脂質への中間体である可能性が示唆された。この現象はin vitroにて再現できた。また、肝癌、大腸癌におけるリゾリン脂質定量、関連受容体・酵素の発現を検討し、リゾリン脂質の肝癌、大腸癌進展における関与について疫学的検討およびin vitroの実験にて示した。また、胃癌腹水を用いた検討でも、グリセロリゾリン脂質の増加、病態への関連を追求する意義を確認し、腹膜癌播種モデルマウスでも再現されることを発見した。
【本田グループ】
・尋常性乾癬のマウスモデルを用いて、高脂肪食中の飽和脂肪酸が皮膚血管内皮細胞からの細胞遊走因子発現誘導という新規メカニズムを見出した。一方、オメガ3脂肪酸由来脂質代謝物であるレゾルビンE1は皮膚樹状細胞からのIL-23産生制御を介し、IL-17産生細胞の増殖や活性化を制御することで乾癬発症に抑制的に作用することを明らかとした。またオメガ6脂肪酸由来脂質代謝物であるトロンボキサンが、IL-17産生を促進することで、乾癬病態に促進的作用をすることを見出した。乾癬病変部でトロンボキサン産生酵素は上昇しており、バイオマーカーとしてのトロンボキサンの可能性も示唆された。

Current Status of Research Progress
Current Status of Research Progress

2: Research has progressed on the whole more than it was originally planned.

Reason

本研究においては、リポクオリティを切り口としたヒト疾患の理解に臨床医(臨床検査医・内科医として矢冨、皮膚科医として本田)の視点・立場から取り組むとしていたが、循環器・動脈硬化性疾患、悪性腫瘍(肝細胞癌など)、皮膚免疫・アレルギー疾患に関して、順調に成果をあげることができ、計画通り進行していると考えられる。
特に、急性冠動脈疾患におけるLPA、癌におけるマイナーグリセロリゾリン脂質、乾癬発症におけるトロンボキサン受容体の関与の重要性を明らかにすることができ、これらの現象の疾患における意義を基礎実験によって解明できつつある。
また、研究倫理委員会の承認の元、各種疾患の血液、組織(癌組織、皮膚など)を中心に、着実に、検体収集を行い、領域全体の臨床検体センターとしての基盤も整えた。

Strategy for Future Research Activity

【矢冨グループ】
臨床研究は、平成29年度の研究を継続して行う。また、癌の病態生理へのリポクオリティの関与について検討するため、癌の進展に関係があるとされる物質の発現を検討し、リゾリン脂質や関連蛋白の発現との関係について検討を行う。基礎研究では、平成29年度の研究を継続するとともに、多価不飽和LPAが増加する機序にリポ蛋白の糖化が関係するかどうか、マウスモデルを用いて検討を行う。また、脊髄損傷モデルラットを用い、ATX阻害薬の疼痛疾患への応用について企業と共同研究する。また、臨床検体センターとして、佐々木班(佐々木、青木)、杉本班(村上)との共同研究も推進する。
【本田グループ】
高脂肪食が乾癬病態に及ぼす作用メカニズム、オメガ3脂肪酸由来脂質(レゾルビンE1)の乾癬制御メカニズムを動物モデルにてさらに検討し、作用点を明確にする。またトロンボキサンの乾癬バイオマーカーとしての可能性を、臨床検体を用いて解析する
。また、腸内細菌由来脂質代謝物が乾癬病態に及ぼす作用について、動物モデルを用いて検討する。また食事内容、運動情報データとともに、腸内細菌叢・脂質代謝物解析を進め、疾患制御候補の腸内細菌由来脂質代謝物を少なくとも一つ選定し、標的細胞・作用メカニズムを解析する。

Report

(3 results)
  • 2017 Annual Research Report
  • 2016 Annual Research Report
  • 2015 Annual Research Report

Research Products

(56 results)

All 2018 2017 2016 2015 Other

All Journal Article Presentation Book Remarks Funded Workshop

  • [Journal Article] Apolipoprotein M Protects Lipopolysaccharide-Treated Mice from Death and Organ Injury.2018

    • Author(s)
      Tsuneyama Koichi、Morimoto Yuki、Shimizu Tomo、Jona Masahiro、Kassai Hidetoshi、Nakao Kazuki、Aiba Atsu、Kurano Makoto、Yatomi Yutaka
    • Journal Title

      Thromb Haemost.

      Volume: -

    • DOI
      10.1055/s-0038-1641750
    • Related Report
      2017 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Measurement of plasma choline in acute coronary syndrome: importance of suitable sampling conditions for this assay.2018

    • Author(s)
      Ohkawa Ryunosuke、Kurano Makoto、Sakai Noboru、Kishimoto Tatsuya、Nojiri Takahiro、Igarashi Koji、Hosogaya Shigemi、Ozaki Yukio、Dohi Tomotaka、Miyauchi Katsumi、Daida Hiroyuki、Aoki Junken、Okubo Shigeo、Ikeda Hitoshi、Tozuka Minoru、Yatomi Yutaka
    • Journal Title

      Sci Rep.

      Volume: 8 Pages: 1-12

    • DOI
      10.1038/s41598-018-23009-x
    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Association between serum autotaxin or phosphatidylserine-specific phospholipase A1 levels and melanoma2018

    • Author(s)
      Kurano Makoto、Miyagaki Tomomitsu、Miyagawa Takuya、Igarashi Koji、Shimamoto Satoshi、Ikeda Hitoshi、Aoki Junken、Sato Shinichi、Yatomi Yutaka
    • Journal Title

      The Journal of Dermatology

      Volume: -

    • DOI
      10.1111/1346-8138.14278
    • Related Report
      2017 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Sitosterol prevents obesity-related chronic inflammation2018

    • Author(s)
      Kurano Makoto、Hasegawa Koji、Kunimi Motoei、Hara Masumi、Yatomi Yutaka、Teramoto Tamio、Tsukamoto Kazuhisa
    • Journal Title

      Biochim Biophys Acta

      Volume: 1863 Pages: 191-198

    • DOI
      10.1016/j.bbalip.2017.12.004
    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Sphingosine 1-Phosphate and Atherosclerosis2018

    • Author(s)
      Kurano Makoto、Yatomi Yutaka
    • Journal Title

      J Atheroscler Thromb

      Volume: 25 Issue: 1 Pages: 16-26

    • DOI
      10.5551/jat.RV17010
    • NAID
      130006301107
    • Related Report
      2017 Annual Research Report
    • Peer Reviewed
  • [Journal Article] The 17,18-epoxyeicosatetraenoic acid-G protein-coupled receptor 40 axis ameliorates contact hypersensitivity by inhibiting neutrophil mobility in mice and cynomolgus macaques2018

    • Author(s)
      Nagatake T, Shiogama Y, Inoue A, Kikuta J, Honda T, Tiwari P, Kishi T, Yanagisawa A, Isobe Y, Matsumoto N, Shimojou M, Morimoto S, Suzuki H, Hirata S, Steneberg P, Edlund H, Aoki J, Arita M, Kiyono H, Yasutomi Y, Ishii M, Kabashima K, Kunisawa J
    • Journal Title

      J Allergy Clin Immunol

      Volume: S0091-6749 Pages: 32949-32944

    • DOI
      10.1016/j.jaci.2017.09.053
    • NAID
      120006501316
    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Thromboxane A2 facilitates IL-17A production from Vγ4+ γδ T cells and promotes psoriatic dermatitis in mice.2018

    • Author(s)
      Ueharaguchi Y, Honda T, Kusuba N, Hanakawa S, Adachi A, Sawada Y, Otsuka A, Kitoh A, Dainichi T, Egawa G, Nakashima C, Nakajima S, Murata T, Ono S, Arita M, Narumiya S, Miyachi M, Kabashima K.
    • Journal Title

      J Allergy Clin Immunol

      Volume: -

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Multipolarity of cytokine axes in the pathogenesis of atopic dermatitis in terms of age, race, species, disease stage and biomarkers2018

    • Author(s)
      Nomura Takashi、Honda Tetsuya、Kabashima Kenji
    • Journal Title

      International Immunology

      Volume: -

    • DOI
      10.1093/intimm/dxy015
    • Related Report
      2017 Annual Research Report
  • [Journal Article] Evidence Suggests Sphingosine 1-Phosphate Might Be Actively Generated, Degraded, and Transported to Extracellular Spaces With Increased S1P 2 and S1P 3 Expression in Colon?Cancer2017

    • Author(s)
      Uranbileg B, Nishikawa T, Ikeda H, Kurano M, Sato M, Saigusa D, Aoki J, Watanabe T, Yatomi Y.
    • Journal Title

      Clinical Colorectal Cancer

      Volume: Nov 21. pii: Pages: 30369-9

    • DOI
      10.1016/j.clcc.2017.11.004
    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Involvement of Band 3 in the efflux of sphingosine 1-phospate from erythrocytes2017

    • Author(s)
      Kurano M, Nishikawa M, Kuma H, Jona M, Yatomi Y.
    • Journal Title

      PLos One

      Volume: 12

    • DOI
      10.1371/journal.pone.0177543
    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Analysis of glycero-lysophospholipids in gastric cancerous ascites2017

    • Author(s)
      Emoto, S., Kurano, M., Kano, K., Matsusaki, K., Yamashita, H., Nishikawa, M., Igarashi, K., Ikeda, H., Aoki, J., Kitayama, J., and Yatomi, Y.
    • Journal Title

      Journal of Lipid Research

      Volume: 58 Pages: 763-771

    • DOI
      10.1194/jlr.p072090
    • Related Report
      2017 Annual Research Report 2016 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] High fat diet exacerbates murine psoriatic dermatitis by increasing the number of IL-17-producing γδ T cells.2017

    • Author(s)
      Nakamizo Satoshi、Honda Tetsuya、Adachi Akimasa、Nagatake Takahiro、Kunisawa Jun、Kitoh Akihiko、Otsuka Atsushi、Dainichi Teruki、Nomura Takashi、Ginhoux Florent、Ikuta Koichi、Egawa Gyohei、Kabashima Kenji
    • Journal Title

      Sci. Rep.

      Volume: 7 Pages: 14076-14076

    • DOI
      10.1038/s41598-017-14292-1
    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Involvement of CETP (Cholesteryl Ester Transfer Protein) in the Shift of Sphingosine-1-Phosphate Among Lipoproteins and in the Modulation of its Functions.2017

    • Author(s)
      Kurano, M., Hara, M., Ikeda, H., Tsukamoto, K., and Yatomi, Y
    • Journal Title

      Arterioscler Thromb Vasc Biol.

      Volume: 37 Pages: 506-514

    • DOI
      10.1161/atvbaha.116.308692
    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Different origins of lysophospholipid mediators between coronary and peripheral arteries in acute coronary syndrome.2017

    • Author(s)
      Kurano, M., Kano, K., Dohi, T., Matsumoto, H., Igarashi, K., Nishikawa, M., Ohkawa, R., Ikeda, H., Miyauchi, K., Daida, H., Aoki, J., and Yatomi, Y.
    • Journal Title

      J Lipid Res.

      Volume: 58 Pages: 433-442

    • DOI
      10.1194/jlr.p071803
    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Vehicle-dependent Effects of Sphingosine 1-phosphate on Plasminogen Activator Inhibitor-1 Expression2017

    • Author(s)
      Takahashi, C., Kurano, M., Nishikawa, M., Kano, K., Dohi, T., Miyauchi, K., Daida, H., Shimizu, T., Aoki, J., and Yatomi, Y.
    • Journal Title

      J Atheroscler Thromb

      Volume: in press Issue: 9 Pages: 954-969

    • DOI
      10.5551/jat.37663
    • NAID
      130006038432
    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Receptor-interacting protein kinase 3 controls keratinocyte activation in a necroptosis-independent manner and promotes psoriatic dermatitis in mice2017

    • Author(s)
      Tetsuya Honda, Osamu Yamamoto MD, Yu Sawada, Gyohei Egawa, Akihiko Kitoh, Atsushi Otsuka, Teruki Dainichi, Saeko Nakajima, Yoshiki Miyachi, Kenji Kabashima
    • Journal Title

      J Allergy Clin Immunol.

      Volume: 5

    • DOI
      10.1016/j.jaci.2017.02.027
    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Higher LPA2 and LPA6 mRNA levels in hepatocellular carcinoma are associated with poorer differentiation, microvascular invasion and earlier recurrence with higher serum autotaxin levels2016

    • Author(s)
      Enooku K, Uranbileg B, Ikeda H, Kurano M, Sato M, Kudo H, Maki H, Koike K, Hasegawa K, Kokudo N, Yatomi Y.
    • Journal Title

      PLoS One

      Volume: 11

    • DOI
      10.1371/journal.pone.0161825
    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Resveratrol exerts a biphasic effect on apolipoprotein M2016

    • Author(s)
      Kurano M, Hara M, Nojiri T, Ikeda H, Tsukamoto K, Yatomi Y.
    • Journal Title

      Br. J. Pharmacol.

      Volume: 173 Pages: 222-233

    • DOI
      10.1111/bph.13360
    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Regulation of the lysophosphatidylserine and sphingosine 1-phosphate levels in autologous whole blood by the pre-storage leukocyte reduction2016

    • Author(s)
      Nagura, Y., Tsuno, NH., Kano, K., Inoue, A., Aoki, J., Hirowatari, Y., Kaneko, M., Kurano, M., Matsuhashi, M., Ohkawa, R., Tozuka, M., Yatomi, Y., and Okazaki, H.
    • Journal Title

      Transfus Med

      Volume: 26 Pages: 365-372

    • DOI
      10.1111/tme.12326
    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Sphingosine kinase-1, S1P transporter spinster homolog 2 and S1P2 mRNA expressions are increased in liver with advanced fibrosis in human2016

    • Author(s)
      Sato M, Ikeda H, Uranbileg B, Kurano M, Saigusa D, Aoki J, Maki H, Kudo H, Hasegawa K, Kokudo N, Yatomi Y.
    • Journal Title

      Scientific Reports

      Volume: 6 Pages: 32119-32119

    • DOI
      10.1038/srep32119
    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Serum Autotaxin Levels Are Associated with Proteinuria and Kidney Lesions in Japanese Type 2 Diabetic Patients with Biopsy-proven Diabetic Nephropathy2016

    • Author(s)
      Shimizu M, Furuichi K, Toyama T, Yamahana J, Ohkawa R, Igarashi K, Aoki J, Kaneko S, Yatomi Y, Wada T
    • Journal Title

      Intern. Med.

      Volume: 55 Issue: 3 Pages: 215-21

    • DOI
      10.2169/internalmedicine.55.5473
    • NAID
      130005122604
    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Increased mRNA levels of sphingosine kinases and S1P lyase and reduced levels of S1P were observed in hepatocellular carcinoma in association with poorer differentiation and earlier recurrence.2016

    • Author(s)
      Uranbileg B, Ikeda H, Kurano M, Enooku K, Sato M, Saigusa D, Aoki J, Ishizawa T, Hasegawa K, Kokudo N, Yatomi Y.
    • Journal Title

      PLOS ONE

      Volume: 11

    • DOI
      10.1371/journal.pone.0149462
    • Related Report
      2016 Annual Research Report 2015 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Prostanoids in allergy2015

    • Author(s)
      Honda T, Kabashima K.
    • Journal Title

      Allergol. Int.

      Volume: 64 Issue: 1 Pages: 11-16

    • DOI
      10.1016/j.alit.2014.08.002
    • NAID
      130004873121
    • Related Report
      2015 Annual Research Report
    • Peer Reviewed
  • [Presentation] 植物ステロール吸収促進は,肥満による慢性炎症を抑制する2017

    • Author(s)
      蔵野 信,長谷川 浩司,国見 基瑩,原 眞純,矢冨 裕,塚本 和久
    • Organizer
      第60回 日本糖尿病学会年次学術集会
    • Related Report
      2017 Annual Research Report
  • [Presentation] K562細胞は,リゾホスファチジルセリンにより巨核球への分化誘導が修飾される2017

    • Author(s)
      蔵野 信,西川 真子,矢冨 裕
    • Organizer
      第39回 日本血栓止血学会学術集会
    • Related Report
      2017 Annual Research Report
  • [Presentation] リポ蛋白代謝・修飾によるグリセロリゾリン脂質の変動2017

    • Author(s)
      蔵野 信,可野 邦行,小林 玉宜,青木 淳賢,矢冨 裕
    • Organizer
      第59回 日本脂質生化学会
    • Related Report
      2017 Annual Research Report
  • [Presentation] 酸化,糖化によるリポ蛋白中のリゾリン脂質変化とその意義2017

    • Author(s)
      蔵野 信,可野 邦之,青木 淳賢,矢冨 裕
    • Organizer
      第32回 日本糖尿病合併症学会
    • Related Report
      2017 Annual Research Report
  • [Presentation] ホスファチジルセリン特異的ホスホリパーゼA1,リゾホスファチジルセリンの糖尿病の病態生理への関与の解明2017

    • Author(s)
      蔵野 信,五十嵐 浩二,池田 均,塚本 和久,矢冨 裕
    • Organizer
      第64回 日本臨床検査医学会学術集会
    • Related Report
      2017 Annual Research Report
  • [Presentation] Glycation of Apolipoprotein M attenuated its capacity to bind Sphingosine-1 Phosphate.2017

    • Author(s)
      Kobayashi, T., Kurano, M., Mishima, Y., Nojiri, T., Ohkawa, R., Tozuka, M., and Yatomi, Y.
    • Organizer
      The 29th World Congress of World Association of Societies of Pathology and Laboratory Medicine (WASPaLM)
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Possible involvement of glycero-lysophopholipids in the pathogenesis of ACS, revealed by an LC/MS technique.2017

    • Author(s)
      Kurano, M., Kano, K., Dohi, T., Ikeda, H., Aoki, J., and Yatomi Y
    • Organizer
      The 29th World Congress of World Association of Societies of Pathology and Laboratory Medicine (WASPaLM).
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Difference between sphingosine 1-phosphate and dihydrosphingosine 1-phosphate in their preference to HDL or albumin.2017

    • Author(s)
      Mishima,Y., Kurano,M., Kobayahsi,T., Nishikawa,M., Ohkawa,R., Tozuka,M.,Yatomi,Y
    • Organizer
      The 29th World Congress of World Association of Societies of Pathology and Laboratory Medicine (WASPaLM).
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Clinical Significance of Autotaxin in the field of Hematology.2017

    • Author(s)
      Nishikawa, M., Kurano, M., Shimamoto, S., Igarashi, K., Yatomi, Y.
    • Organizer
      The 29th World Congress of World Association of Societies of Pathology and Laboratory Medicine (WASPaLM).
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Serum autotaxin is increased and correlated with thyroid hormone in Graves' disease.2017

    • Author(s)
      Nojiri, T., Kurano, M., Nakawatari, K. Shimamoto,S., Igarashi, K., Sone, S., Ikeda, H., and Yatomi, Y.
    • Organizer
      The 29th World Congress of World Association of Societies of Pathology and Laboratory Medicine (WASPaLM).
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] S1P is actively metabolized and transported to extracellular spaces with increased receptors expression in colon cancer.2017

    • Author(s)
      Uranbileg, B., Nishikawa,T., Ikeda, H., Kurano, M., Sato, M., Saigusa, D., Aoki, J., Watanabe, T., and Yatomi, Y
    • Organizer
      The 29th World Congress of World Association of Societies of Pathology and Laboratory Medicine (WASPaLM).
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Identification of resolvin E1, an omega-3 poly-unsaturated fatty acids-derived lipid mediator, as an inhibitor for psoriatic dermatitis.2017

    • Author(s)
      本田 哲也
    • Organizer
      第42回日本研究皮膚科学会
    • Related Report
      2017 Annual Research Report
  • [Presentation] リポクオリティに着目した新しい臨床検査の可能性2017

    • Author(s)
      矢冨 裕
    • Organizer
      第42回日本医用マススペクトル学会年会
    • Related Report
      2017 Annual Research Report
    • Invited
  • [Presentation] Development of clinical laboratory tests from the viewpoint of lipoquality2017

    • Author(s)
      Yatomi Y
    • Organizer
      International Conference on Lipoquality 2017
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Diet in the pathogenesis of psoriasis: a review of recent progress2016

    • Author(s)
      本田哲也
    • Organizer
      第41回日本研究皮膚科学会
    • Place of Presentation
      仙台
    • Year and Date
      2016-12-09
    • Related Report
      2016 Annual Research Report
    • Invited
  • [Presentation] リコンビナントアポ蛋白Mを利用した多臓器不全に対する新規治療法の開発2016

    • Author(s)
      蔵野 信,矢冨 裕
    • Organizer
      第56回 日本臨床化学会年次学術集会
    • Place of Presentation
      熊本
    • Year and Date
      2016-12-03
    • Related Report
      2016 Annual Research Report
  • [Presentation] Involvement of Lysophosphatidylserine in the Pathophysiology of Hepatocellular Carcinoma2016

    • Author(s)
      Baasanjav Uranbileg, Hitoshi Ikeda, Makoto Kurano, Yutaka Yatomi
    • Organizer
      第56回 日本臨床化学会年次学術集会
    • Place of Presentation
      熊本
    • Year and Date
      2016-12-03
    • Related Report
      2016 Annual Research Report
  • [Presentation] Sphingosine 1-Phosphate Possesses the Carrier-dependent Effects on the Plasminogen Activator Inhibitor 1 Expression in Adipocytes2016

    • Author(s)
      Takahashi, C., Kurano, M., Nishikawa, M., Kano, K., Dohi, T., Miyauchi, K., Daida, H., Shimizu, T., Aoki, J., and Yatomi, Y.
    • Organizer
      AHA Scientific Sessions 2016
    • Place of Presentation
      New Orleans, Louisiana, USA
    • Year and Date
      2016-11-12
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] アポ蛋白Mの抗糖尿病性腎症作用2016

    • Author(s)
      蔵野 信,塚本 和久,矢冨 裕
    • Organizer
      第31回 日本糖尿病合併症学会
    • Place of Presentation
      仙台
    • Year and Date
      2016-10-08
    • Related Report
      2016 Annual Research Report
  • [Presentation] Carrier-dependent Effects of Sphingosine 1-phosphate on Plasminogen Activator Inhibitor-1 Expression in Adipocytes2016

    • Author(s)
      Takahashi, C., Kurano, M., Nishikawa, M., and Yatomi, Y.
    • Organizer
      The 9th Congress of the Asia Pacific Society on Thrombosis and Hemostasis
    • Place of Presentation
      Taipei, Chinese Taipei
    • Year and Date
      2016-10-06
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] IgA腎症におけるスフィンゴシン1-リン酸の役割2016

    • Author(s)
      蔵野 信,矢冨 裕
    • Organizer
      第63回 日本臨床検査医学会学術集会
    • Place of Presentation
      神戸
    • Year and Date
      2016-09-02
    • Related Report
      2016 Annual Research Report
  • [Presentation] Detection and Regulation of Apolipoprotein M in Central Nervous System2016

    • Author(s)
      Hisasue, N., Kurano, M., Morimoto, Y., Tsuneyama, K., Kubota, T., Yatomi, Y.
    • Organizer
      The 32nd World Congress of Biomedical Laboratory Science 2016 IFBLS
    • Place of Presentation
      Kobe, Japan
    • Year and Date
      2016-08-31
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Oxidation and Glycation Modulate HDL Capacity to Carry Sphingosine 1-Phosphate, an Anti-Atherosclerotic Bioactive Lipid2016

    • Author(s)
      Kobayashi, T., Kurano, M., Nojiri, T., Ohkawa, R., Tozuka, M., Okubo, S., and Yatomi, Y.
    • Organizer
      The 32nd World Congress of Biomedical Laboratory Science 2016 IFBLS
    • Place of Presentation
      Kobe, Japan
    • Year and Date
      2016-08-31
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 2型糖尿病患者におけるリゾリン脂質関連蛋白と合併症の関係2016

    • Author(s)
      蔵野 信,清水 知,五十嵐 浩二,原 眞純,塚本 和久,矢冨 裕
    • Organizer
      第48回 日本動脈硬化学会学術集会
    • Place of Presentation
      東京
    • Year and Date
      2016-07-15
    • Related Report
      2016 Annual Research Report
  • [Presentation] アポ蛋白Mを用いた播種性血管内凝固症候群,多臓器不全の新規治療法の開発2016

    • Author(s)
      蔵野 信,常山 幸一,常名 政弘,矢冨 裕
    • Organizer
      第38回 日本血栓止血学会学術集会
    • Place of Presentation
      奈良
    • Year and Date
      2016-06-18
    • Related Report
      2016 Annual Research Report
  • [Presentation] The Laboratory Medicine of Lysophospholipids2016

    • Author(s)
      Yatomi, Y., Kurano, M., Ikeda, H., and Aoki, J.
    • Organizer
      Korea-Japan Bioactive Lipid Joint Symposium
    • Place of Presentation
      Jeju Island, South Korea
    • Year and Date
      2016-05-11
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] High fat diet exacerbates psoriatic dermatitis by facilitating IL-17-producing γδT cell accumulation in the skin2016

    • Author(s)
      Tetsuya Honda
    • Organizer
      SID2016 Society of Investigative Dermatology Annual Meeting
    • Place of Presentation
      Scottsdale, USA
    • Year and Date
      2016-05-11
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 糖尿病性腎症におけるアポ蛋白Mの役割2015

    • Author(s)
      蔵野 信,清水 知,矢冨 裕
    • Organizer
      第61回 日本臨床検査医学会学術集会
    • Place of Presentation
      岐阜
    • Year and Date
      2015-11-19
    • Related Report
      2015 Annual Research Report
  • [Presentation] High fat diet exacerbates psoriatic dermatitis by facilitating IL-17-producing gamma delta T cells accumulation in the skin via perivascular adipose tissue2015

    • Author(s)
      中溝聡、本田哲也、椛島健治
    • Organizer
      第14回国際Langerhans細胞ワークショップ
    • Place of Presentation
      京都府京都市左京区 京都市国際交流会館
    • Year and Date
      2015-11-05
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research
  • [Book] 炎症と免疫2017

    • Author(s)
      本田哲也
    • Publisher
      先端医学社
    • Related Report
      2016 Annual Research Report
  • [Remarks] 東京大学医学部附属病院 検査部

    • URL
      http://lab-tky.umin.jp
    • Related Report
      2017 Annual Research Report
  • [Remarks] 東京大学大学院医学系研究科 内科学専攻病態診断医学講座 臨床病態検査医学分野

    • URL
      http://lab-tky.umin.jp
    • Related Report
      2016 Annual Research Report
  • [Funded Workshop] International Conference on Lipoquality 20172017

    • Related Report
      2017 Annual Research Report

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Published: 2015-07-02   Modified: 2019-07-17  

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