| Budget Amount *help |
¥165,490,000 (Direct Cost: ¥127,300,000、Indirect Cost: ¥38,190,000)
Fiscal Year 2019: ¥28,210,000 (Direct Cost: ¥21,700,000、Indirect Cost: ¥6,510,000)
Fiscal Year 2018: ¥29,250,000 (Direct Cost: ¥22,500,000、Indirect Cost: ¥6,750,000)
Fiscal Year 2017: ¥30,290,000 (Direct Cost: ¥23,300,000、Indirect Cost: ¥6,990,000)
Fiscal Year 2016: ¥29,120,000 (Direct Cost: ¥22,400,000、Indirect Cost: ¥6,720,000)
Fiscal Year 2015: ¥48,620,000 (Direct Cost: ¥37,400,000、Indirect Cost: ¥11,220,000)
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| Outline of Final Research Achievements |
In this study, to investigate the mechanism and the physiological significance of intracellular temperature variation, we developed and modified our methodologies of temperature imaging and local heating in single cells. By using these techniques, we investigated temperature changes in various cell lines and tissues to find spatiotemporal temperature variations which depended on cellular states and functions, and furthermore, intracellular local thermogenesis-driven physiological events. These results suggested the existence of intracellular thermal signaling in which the spontaneous local temperature change inside cells contributes to cellular and physiological functions.
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