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Elucidation of the role of circadian clock mechanisms in temperature sensing, temperature response and body temperature control in living organisms

Planned Research

Project AreaIntegrative understanding of biological phenomena with temperature as a key theme
Project/Area Number 15H05933
Research Category

Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)

Allocation TypeSingle-year Grants
Review Section Biological Sciences
Research InstitutionKyoto University

Principal Investigator

Doi Masao  京都大学, 薬学研究科, 教授 (20432578)

Project Period (FY) 2015-06-29 – 2020-03-31
Project Status Completed (Fiscal Year 2019)
Budget Amount *help
¥103,740,000 (Direct Cost: ¥79,800,000、Indirect Cost: ¥23,940,000)
Fiscal Year 2019: ¥18,460,000 (Direct Cost: ¥14,200,000、Indirect Cost: ¥4,260,000)
Fiscal Year 2018: ¥18,590,000 (Direct Cost: ¥14,300,000、Indirect Cost: ¥4,290,000)
Fiscal Year 2017: ¥18,590,000 (Direct Cost: ¥14,300,000、Indirect Cost: ¥4,290,000)
Fiscal Year 2016: ¥18,590,000 (Direct Cost: ¥14,300,000、Indirect Cost: ¥4,290,000)
Fiscal Year 2015: ¥29,510,000 (Direct Cost: ¥22,700,000、Indirect Cost: ¥6,810,000)
Keywords体内時計 / 体温 / 時計遺伝子 / 睡眠 / G蛋白質共役受容体 / 視交叉上核 / 時間生物学 / 温度 / 生理学 / 神経科学 / シグナル伝達 / 時計蛋白質
Outline of Final Research Achievements

To elucidate the role of the circadian clock mechanism in temperature sensing, temperature response, and body temperature control in animals, we established a simple method of detecting temperature-dependent clock protein variation (Tainaka et al., Chronobiol Int 2018) and identified the G-protein-coupled receptor CALCR in the master circadian pacemaker in the brain as a component required for body temperature attenuation during napping (Doi et al., Nat Commun 2016; Goda & Doi et al., Genes Dev 2018). Furthermore, we developed mutant mice carrying a mutation only at the E′-box cis-element in the promoter region of the core clock gene Per2, and revealed, for the first time, the extent of the impact of the non-coding cis-element in daily maintenance of animal body temperature rhythmicity (Doi et al., Nat Commun 2019).

Academic Significance and Societal Importance of the Research Achievements

これまでゲノムの非コード領域は細胞分化などの生物の発生や、進化などへの寄与が示されていたが、成長後の動的な生理的制御での役割が不明であった。本研究は、この問題に対し、独自に開発したシスエレメント点変異マウスを用いることにより、当該エレメントがマウス成体において体温の日内リズムを生み出すことを見出した。蛋白質をコードしないDNA配列の成体における役割を日々の体温制御レベルで明らかにした初めての成果といえる。本研究では、さらに、昼寝という特殊な時間帯の体温を制御する脳内分子CALCR を見出した。昼寝の生物学的意義がつかめぬ状況においてその解明につながる基礎体温調節機序を示すことができたといえる。

Report

(6 results)
  • 2019 Annual Research Report   Final Research Report ( PDF )
  • 2018 Annual Research Report
  • 2017 Annual Research Report
  • 2016 Annual Research Report
  • 2015 Annual Research Report
  • Research Products

    (110 results)

All 2020 2019 2018 2017 2016 2015 Other

All Int'l Joint Research (4 results) Journal Article (34 results) (of which Int'l Joint Research: 11 results,  Peer Reviewed: 22 results,  Open Access: 12 results,  Acknowledgement Compliant: 2 results) Presentation (61 results) (of which Int'l Joint Research: 18 results,  Invited: 27 results) Book (4 results) Remarks (7 results)

  • [Int'l Joint Research] Florida State University(米国)

    • Related Report
      2019 Annual Research Report
  • [Int'l Joint Research] シンシナティ病院(米国)

    • Related Report
      2017 Annual Research Report
  • [Int'l Joint Research] シンシナティ大学(米国)

    • Related Report
      2016 Annual Research Report
  • [Int'l Joint Research] リューベック大学(ドイツ)

    • Related Report
      2016 Annual Research Report
  • [Journal Article] Identification and functional characterisation of N-linked glycosylation of the orphan G protein-coupled receptor Gpr1762020

    • Author(s)
      Tianyu Wang, Shumpei Nakagawa, Takahito Miyake, Genzui Setsu, Sumihiro Kunisue, Kaoru Goto, Akira Hirasawa, Hitoshi Okamura, Yoshiaki Yamaguchi, Masao Doi
    • Journal Title

      Scientific Reports

      Volume: 10 Issue: 1 Pages: 4429-4429

    • DOI

      10.1038/s41598-020-61370-y

    • NAID

      120006822520

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] 体内時計の中枢を調節するG蛋白質共役型受容体2020

    • Author(s)
      嶋谷 寛之、土居 雅夫
    • Journal Title

      膜タンパク質工学ハンドブック

      Volume: 1 Pages: 344-348

    • Related Report
      2019 Annual Research Report
  • [Journal Article] Reconstitution of Organismal Liver Clock Function Requires Light.2019

    • Author(s)
      Takahito Miyake, Masao Doi
    • Journal Title

      Trends in endocrinology and metabolism

      Volume: 30 Issue: 9 Pages: 569-571

    • DOI

      10.1016/j.tem.2019.07.017

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Non-coding cis-element of Period2 is essential for maintaining organismal circadian behaviour and body temperature rhythmicity2019

    • Author(s)
      Doi Masao、Shimatani Hiroyuki、Atobe Yuta、Murai Iori、Hayashi Hida、Takahashi Yukari、Fustin Jean-Michel、Yamaguchi Yoshiaki、Kiyonari Hiroshi、Koike Nobuya、Yagita Kazuhiro、Lee Choogon、Abe Manabu、Sakimura Kenji、Okamura Hitoshi
    • Journal Title

      Nature Communications

      Volume: 10 Issue: 1 Pages: 2563-2563

    • DOI

      10.1038/s41467-019-10532-2

    • NAID

      120006644061

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] 昼寝の時刻の体温を制御する脳内中枢時計の分子機構2019

    • Author(s)
      前川 洋太、土居 雅夫
    • Journal Title

      内分泌・糖尿病・代謝内科

      Volume: 48 Pages: 415-419

    • Related Report
      2019 Annual Research Report
  • [Journal Article] Two Ck1δ transcripts regulated by m6A methylation code for two antagonistic kinases in the control of the circadian clock2018

    • Author(s)
      Fustin Jean-Michel、Kojima Rika、Itoh Kakeru、Chang Hsin-Yi、Ye Shiqi、Zhuang Bowen、Oji Asami、Gibo Shingo、Narasimamurthy Rajesh、Virshup David、Kurosawa Gen、Doi Masao、Manabe Ichiro、Ishihama Yasushi、Ikawa Masahito、Okamura Hitoshi
    • Journal Title

      Proceedings of the National Academy of Sciences

      Volume: 115 Issue: 23 Pages: 5980-5985

    • DOI

      10.1073/pnas.1721371115

    • NAID

      120006957427

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Fetal Leydig cells dedifferentiate and serve as adult Leydig stem cells2018

    • Author(s)
      Shima Yuichi、Miyabayashi Kanako、Sato Tetsuya、Suyama Mikita、Ohkawa Yasuyuki、Doi Masao、Okamura Hitoshi、Suzuki Kentaro
    • Journal Title

      Development

      Volume: 145 Issue: 23 Pages: 169136-169136

    • DOI

      10.1242/dev.169136

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 体内時計の中枢を調節するG蛋白質共役型受容体シグナル2018

    • Author(s)
      中川 峻平, 土居雅夫
    • Journal Title

      医学のあゆみ

      Volume: 267 Pages: 429-433

    • Related Report
      2018 Annual Research Report
  • [Journal Article] 特集企画 生体リズムを基盤とした時間医薬科学の展開2018

    • Author(s)
      土居雅夫
    • Journal Title

      医学のあゆみ

      Volume: 267 Pages: 427-427

    • Related Report
      2018 Annual Research Report
  • [Journal Article] Calcitonin receptors are ancient modulators for rhythms of preferential temperature in insects and body temperature in mammals2018

    • Author(s)
      Goda Tadahiro、Doi Masao、Umezaki Yujiro、Murai Iori、Shimatani Hiroyuki、Chu Michelle L.、Nguyen Victoria H.、Okamura Hitoshi、Hamada Fumika N.
    • Journal Title

      Genes & Development

      Volume: 32 Issue: 2 Pages: 140-155

    • DOI

      10.1101/gad.307884.117

    • NAID

      120006401705

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Circadian coordination of ATP release in the urothelium via connexin43 hemichannels2018

    • Author(s)
      Sengiku A, Ueda M, Kono J, Sano T, Nishikawa N, Kunisue S, Tsujihana K, Liou L, Kanematsu A, Shimba S, Doi M, Okamura H, Ogawa O, and Negoro H
    • Journal Title

      Sci. Rep.

      Volume: 8 Issue: 1 Pages: 1996-1996

    • DOI

      10.1038/s41598-018-20379-0

    • NAID

      120006510288

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] <b>Circadian rhythms of micturition during jet </b><b>lag </b>2018

    • Author(s)
      Ito K, Yasuda M, Maeda Y, Fustin JM, Yamaguchi Y, Kono Y, Negoro H, Kanematsu A, Ogawa O, Doi M, and Okamura H
    • Journal Title

      Biomedical Research

      Volume: 39 Issue: 2 Pages: 57-63

    • DOI

      10.2220/biomedres.39.57

    • NAID

      130006708567

    • ISSN
      0388-6107, 1880-313X
    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Effect of daily light on c-Fos expression in the suprachiasmatic nucleus under the jet lag condition.2018

    • Author(s)
      Chen Y, Yamaguchi Y, Suzuki T, Doi M, and Okamura H
    • Journal Title

      Acta Histochem. Cytochem.

      Volume: 印刷中

    • NAID

      130006727962

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Circadian PER2 protein oscillations do not persist in cycloheximide-treated mouse embryonic fibroblasts in culture2018

    • Author(s)
      Tainaka Motomi、Doi Masao、Inoue Yuichi、Murai Iori、Okamura Hitoshi
    • Journal Title

      Chronobiology International

      Volume: 35 Issue: 1 Pages: 132-136

    • DOI

      10.1080/07420528.2017.1316731

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] 「昼寝」の体温リズムを調整する遺伝子を発見2018

    • Author(s)
      土居 雅夫
    • Journal Title

      化学

      Volume: 73 Pages: 73-73

    • Related Report
      2017 Annual Research Report
  • [Journal Article] Gz-linked orphan GPCR regulating the center of the circadian clock2017

    • Author(s)
      國末 純宏, 土居 雅夫
    • Journal Title

      生化学

      Volume: 89 Issue: 5 Pages: 752-755

    • DOI

      10.14952/SEIKAGAKU.2017.890752

    • NAID

      40021377448

    • ISSN
      0037-1017
    • Year and Date
      2017-10-25
    • Related Report
      2017 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Circadian clock regulates hepatic polyploidy by modulating Mkp1-Erk1/2 signaling pathway.2017

    • Author(s)
      Chao HW, Doi M, Fustin JM, Chen H, Murase K, Maeda Y, Hayashi H, Tanaka R, Sugawa M, Mizukuchi N, Yamaguchi Y, Yasunaga J, Matsuoka M, Sakai M, Matsumoto M, Hamada S, and Okamura H
    • Journal Title

      Nature Commun.

      Volume: 8 Issue: 1 Pages: 2238-2238

    • DOI

      10.1038/s41467-017-02207-7

    • NAID

      120006373904

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] G-protein-coupled receptor signaling through Gpr176, Gz, and RGS16 tunes time in the center of the circadian clock [Review]2017

    • Author(s)
      Goto Kaoru、Doi Masao、Wang Tianyu、Kunisue Sumihiro、Murai Iori、Okamura Hitoshi
    • Journal Title

      Endocrine Journal

      Volume: 64 Issue: 6 Pages: 571-579

    • DOI

      10.1507/endocrj.EJ17-0130

    • NAID

      130007307959

    • ISSN
      0918-8959, 1348-4540
    • Related Report
      2017 Annual Research Report 2016 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] <i><b>Gm7325</b></i><b> is MyoD-dependently expressed in activated muscle satellite </b><b>cells </b>2017

    • Author(s)
      Takei D, Nishi M, Fukada S, Doi M, Okamura H, Uezumi A, Zhang L, Yoshida M, Miyazato M, Ichimura A, Takeshima H.
    • Journal Title

      Biomedical Research

      Volume: 38 Issue: 3 Pages: 215-219

    • DOI

      10.2220/biomedres.38.215

    • NAID

      130006865614

    • ISSN
      0388-6107, 1880-313X
    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Carbachol induces phase-dependent phase shifts of Per1 transcription rhythms in cultured suprachiasmatic nucleus slices.2017

    • Author(s)
      Dojo K, Yamaguchi Y, Fustin JM, Doi M, Kobayashi M, and Okamura H
    • Journal Title

      J. Biol. Rhythms

      Volume: 32 Issue: 2 Pages: 101-108

    • DOI

      10.1177/0748730417691205

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Circadian PER2 protein oscillations do not persist in cycloheximide-treated mouse embryonic fibroblasts in culture.2017

    • Author(s)
      Tainaka M, Doi M, Inoue Y, Murai I, and Okamura H
    • Journal Title

      Chronobiol. Int.

      Volume: 印刷中

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Carbachol Induces phase-dependent phase shifts of Per1 transcription rhythms in cultured suprachiasmatic nucleus slices.2017

    • Author(s)
      Dojo K, Yamaguchi Y, Fustin JM, Doi M, Kobayashi M, and Okamura H
    • Journal Title

      J. Biol. Rhythms

      Volume: 印刷中

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Clock genes and salt-sensitive hypertension: a new type of aldosterone-synthesizing enzyme controlled by the circadian clock and angiotensin II.2016

    • Author(s)
      Okamura H, Doi M, Goto K, and Kojima R
    • Journal Title

      Hypertens. Res.

      Volume: 39 Issue: 10 Pages: 681-687

    • DOI

      10.1038/hr.2016.91

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 体内時計の中枢を制御するオーファンGPCRの同定2016

    • Author(s)
      土居 雅夫, 岡村 均
    • Journal Title

      医学のあゆみ

      Volume: 257 Pages: 790-791

    • Related Report
      2016 Annual Research Report
  • [Journal Article] 体内時計の中枢を制御するオーファンG蛋白質共役受容体2016

    • Author(s)
      土居 雅夫, 岡村 均
    • Journal Title

      BIO Clinica

      Volume: 31 Pages: 43-47

    • Related Report
      2016 Annual Research Report
  • [Journal Article] 生活習慣病と体内時計2016

    • Author(s)
      土居 雅夫
    • Journal Title

      日本内科学会雑誌

      Volume: 105 Pages: 1669-1674

    • Related Report
      2016 Annual Research Report
  • [Journal Article] Gpr176 is a Gz-linked orphan G-protein coupled receptor that sets the pace of circadian behavior.2016

    • Author(s)
      Doi M, Murai I, Kunisue S, Setsu G, Uchio N, Tanaka R, Kobayashi S, Shimatani H, Hayashi H, Chao HW, Nakagawa Y, Takahashi Y, Hotta Y, Yasunaga JI, Matsuoka M, Hastings MH, Kiyonari H, and Okamura H.
    • Journal Title

      Nat Commun

      Volume: 7 Issue: 1 Pages: 10583-10583

    • DOI

      10.1038/ncomms10583

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Real-time recording of circadian Per1 and Per2 expression in the suprachiasmatic nucleus of freely moving rats.2016

    • Author(s)
      Yamaguchi Y, Okada K, Mizuno T, Ota T, Yamada H, Doi M, Kobayashi M, Tei H, Shigeyoshi Y, and Okamura H
    • Journal Title

      J. Biol. Rhythms.

      Volume: 31 Issue: 1 Pages: 108-111

    • DOI

      10.1177/0748730415621412

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 生体リズムを調節するGPCR2016

    • Author(s)
      土居 雅夫, 岡村 均
    • Journal Title

      医学のあゆみ

      Volume: 256, Pages: 15984-15989

    • Related Report
      2015 Annual Research Report
  • [Journal Article] Stimulus-selective induction of the orphan nuclear receptor NGFIB underlies different influences of angiotensin II and potassium on the human adrenal gland zona glomerulosa-specific 3&beta;-HSD isoform gene expression in adrenocortical H295R cells2015

    • Author(s)
      Yarimizu D, Doi M, Ota T, and Okamura H
    • Journal Title

      Endocrine Journal

      Volume: 62 Issue: 9 Pages: 765-776

    • DOI

      10.1507/endocrj.EJ15-0211

    • NAID

      130005100644

    • ISSN
      0918-8959, 1348-4540
    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] 3ß-hydroxysteroid dehydrogenase isoforms in human aldosterone-producing adenoma2015

    • Author(s)
      Konosu-Fukaya S, Nakamura Y, Satoh F, Ono Y, Felizola SJ, Ise K, Maekawa T, Takeda K, Katsu K, Fujishima F, Kasajima A, Watanabe M, Arai Y, Gomez-Sanchez EP, Gomez-Sanchez CE, Doi M, Okamura H, and Sasano H
    • Journal Title

      Mol. Cell. Endocrinol.

      Volume: 印刷中 Pages: 205-212

    • DOI

      10.1016/j.mce.2014.10.008

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] 概日リズム異常による高血圧2015

    • Author(s)
      鑓水 大介, 土居 雅夫, 岡村 均
    • Journal Title

      Medical Science Digest

      Volume: 18 Pages: 394-397

    • Related Report
      2015 Annual Research Report
  • [Journal Article] 新しいアルドステロン症の病理診断2015

    • Author(s)
      土居 雅夫, 岡村 均
    • Journal Title

      腎臓内科・泌尿器科

      Volume: 2 Pages: 404-409

    • NAID

      40022582721

    • Related Report
      2015 Annual Research Report
  • [Journal Article] 中枢時計とエネルギー代謝制御2015

    • Author(s)
      薛 元瑞, 土居 雅夫, 岡村 均
    • Journal Title

      内分泌・糖尿病・代謝内科

      Volume: 41 Pages: 36-42

    • Related Report
      2015 Annual Research Report
  • [Presentation] Real-time FRET imaging of circadian kinase activity in ex vivo cultured SCN slices2020

    • Author(s)
      Youichi Tanaka, Masao Doi
    • Organizer
      第140回日本薬学会年会
    • Related Report
      2019 Annual Research Report
  • [Presentation] 昼寝の体温・代謝リズムを制御する脳内サーカディアンリズム中枢の分子機構2020

    • Author(s)
      土居雅夫
    • Organizer
      第34回日本糖尿病・肥満動物学会
    • Related Report
      2019 Annual Research Report
    • Invited
  • [Presentation] 1.Time-restricted G-protein signaling through Gpr176/Gz/Rgs16 sets the pace of the central clock2019

    • Author(s)
      Masao Doi
    • Organizer
      V World Congress for Chronobiology
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] The orphan G protein-coupled receptor Gpr176 is N-glycosylated in the suprachiasmatic nucleus2019

    • Author(s)
      Tianyu Wang, Genzui Setsu, Masao Doi
    • Organizer
      V World Congress for Chronobiology
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research
  • [Presentation] The suprachiasmatic nucleus-enriched orphan G protein-coupled receptor Gpr176 exerts its cAMP-repressing activity through Gz2019

    • Author(s)
      Shumpei Nakagawa, Sumihiro Kunisue, Masao Doi
    • Organizer
      V World Congress for Chronobiology
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Identification and functional characterization of N-lglycosylation of the orphan Gz-linked receptor Gpr1762019

    • Author(s)
      Shumpei Nakagawa, Tianyu Wang, Masao Doi
    • Organizer
      The 11th Seoul-Kyoto-Osaka Joint Symposium on Pharmaceutical Sciences for Young Scientists
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Optogenetic Assessment of Interneuronal Connectivity between the Central Circadian Clock Neurons2019

    • Author(s)
      Daichi Moriyasu, Yoshiaki Yamaguchi, Masao Doi
    • Organizer
      The 11th Seoul-Kyoto-Osaka Joint Symposium on Pharmaceutical Sciences for Young Scientists
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Per2遺伝子プロモーターシス調節配列E’-boxを欠損したマウス個体の脆弱な概日振動2019

    • Author(s)
      土居雅夫
    • Organizer
      第26回日本時間生物学会年会
    • Related Report
      2019 Annual Research Report
  • [Presentation] Period2遺伝子シス調節エレメントE’-boxを欠損したマウス個体の脆弱な概日振動2019

    • Author(s)
      嶋谷寛之, 跡部祐太, 土居雅夫, 岡村均
    • Organizer
      第26回日本時間生物学会年会
    • Related Report
      2019 Annual Research Report
  • [Presentation] Non-coding cis-regulatory element E’-box of Period2 is essential for daily maintenance of organismal behavior and physiology2019

    • Author(s)
      Masao Doi
    • Organizer
      第3回日本循環器学会基礎研究フォーラム
    • Related Report
      2019 Annual Research Report
    • Invited
  • [Presentation] The circadian clock regulator Gpr176 undergoes N-glycosylation and couples to Gz2019

    • Author(s)
      Masao Doi
    • Organizer
      第15回GPCR研究会
    • Related Report
      2019 Annual Research Report
  • [Presentation] Circadian rhythms in nicotinamide adenine dinucleotide concentration in mouse liver2019

    • Author(s)
      Aya Shimada, Hiroki Nakamura, Daisuke Yarimizu, Masao Doi
    • Organizer
      The 9th Federation of the Asian and Oceanian Physiological Science Congress
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 時差環境下における視交叉上核の光応答性2019

    • Author(s)
      森安大地, 陳宇林, 山口賀章, 鈴木暢, 土居雅夫, 岡村均
    • Organizer
      日本薬学会第139年会
    • Related Report
      2018 Annual Research Report
  • [Presentation] オーファンG蛋白質共役受容体シグナルの生化学を基軸とした生体リズム中枢調整薬の研究開発2019

    • Author(s)
      土居雅夫
    • Organizer
      生化学若い研究者の会 冬のセミナー
    • Related Report
      2018 Annual Research Report
    • Invited
  • [Presentation] Calcitonin Receptor Modulates Body Temperature Rhythm in Mammals -Immunolocalization of the Calcitonin Receptor in Extra-SCN Regions-2018

    • Author(s)
      Yota Maekawa, Yoshiaki Yamaguchi, Iori Murai, Hiroyuki Shimatani, Hitoshi Okamura, Masao Doi
    • Organizer
      International Symposium on Biological Rhythms “20 Years since Discovery of mammalian Clock Genes”
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Light Responsiveness in the Neurons of the Suprachiasmatic Nucleus under Jet Lag Condition2018

    • Author(s)
      Daichi Moriyasu, Yulin Chen, Yoshiaki Yamaguchi, Toru Suzuki, Masao Doi, Hitoshi Okamura
    • Organizer
      International Symposium on Biological Rhythms “20 Years since Discovery of mammalian Clock Genes”
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Carbachol-induced phase-dependent phase-shift of core clock transcription rhythms in slice cultured suprachiasmatic nucleus2018

    • Author(s)
      Kumiko Dojo, Yoshiaki Yamaguchi, Jean-Michel Fustin, Masao Doi, Masaki Kobayashi, Hitoshi Okamura
    • Organizer
      The 9th Congress of Asian Sleep Research Society
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Development of high throughput screening assay method for Gz-linked orphan receptor Gpr1762018

    • Author(s)
      Tianyu Wang, Masao Doi
    • Organizer
      International GPCR Symposium
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Agonist-independent cAMP-repressing activity of the orphan receptor Gpr176 requires Gz2018

    • Author(s)
      Shumpei Nakagawa, Sumihiro Kunisue, Masao Doi
    • Organizer
      International GPCR Symposium
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 昼寝の体温を制御する脳内中枢時計の分子機構2018

    • Author(s)
      土居雅夫
    • Organizer
      第3回バイオサーモロジーワークショップ ー1℃の違いを知るー
    • Related Report
      2018 Annual Research Report
    • Invited
  • [Presentation] 昼寝の体温を制御するGPCR2018

    • Author(s)
      土居雅夫
    • Organizer
      生理学研究所研究会 運動器/代謝系連関による生体機能制御とその変容の仕組み
    • Related Report
      2018 Annual Research Report
    • Invited
  • [Presentation] 体内時計の中枢を制御するG蛋白質共役受容体シグナル2018

    • Author(s)
      土居雅夫
    • Organizer
      第22回睡眠科学研究講座
    • Related Report
      2018 Annual Research Report
    • Invited
  • [Presentation] The detection of cAMP-repressing activity of an SCN-enriched orphan G-protein-coupled receptor Gpr1762018

    • Author(s)
      王甜宇, 土居雅夫
    • Organizer
      第41回日本神経科学大会
    • Related Report
      2018 Annual Research Report
  • [Presentation] Vipr2の視床における発現と網膜入力の影響2018

    • Author(s)
      村井伊織, 土居雅夫, 岡村均
    • Organizer
      第25回日本時間生物学会年会
    • Related Report
      2018 Annual Research Report
  • [Presentation] 時差環境下における日々の光刺激がSCNのc-Fos発現に及ぼす影響2018

    • Author(s)
      森安大地, 陳宇林, 山口賀章, 鈴木暢, 土居雅夫, 岡村均
    • Organizer
      第25回日本時間生物学会年会
    • Related Report
      2018 Annual Research Report
  • [Presentation] Immunohistological distribution of Calcitonin receptor in the brain:Where is a mediator of body temperature rhythm?2018

    • Author(s)
      Yota Maekawa, Yoshiaki Yamaguchi, Iori Murai, Hitoshi Okamura, Masao Doi
    • Organizer
      第25回日本時間生物学会年会
    • Related Report
      2018 Annual Research Report
  • [Presentation] 体温のサーカディアンリズムを制御する脳内中枢時計の分子機構2018

    • Author(s)
      土居雅夫
    • Organizer
      第65回日本実験動物学会総会
    • Related Report
      2018 Annual Research Report
    • Invited
  • [Presentation] 体内時計の中枢を制御するGz共役型オーファンGPCRシグナル2017

    • Author(s)
      土居雅夫、岡村 均
    • Organizer
      第94回 日本生理学会大会
    • Place of Presentation
      浜松
    • Year and Date
      2017-03-30
    • Related Report
      2016 Annual Research Report
    • Invited
  • [Presentation] 脳内中枢時計におけるオーファンG蛋白質共役受容体GPRLの発現プロファイル2017

    • Author(s)
      後藤 馨、村井伊織、土居雅夫、岡村 均
    • Organizer
      第137回日本薬学会年会
    • Place of Presentation
      仙台
    • Year and Date
      2017-03-27
    • Related Report
      2016 Annual Research Report
  • [Presentation] オーファンGPCRを介した生体リズム中枢の制御2017

    • Author(s)
      土居雅夫、岡村 均
    • Organizer
      第137回 日本薬学会年会
    • Place of Presentation
      仙台
    • Year and Date
      2017-03-25
    • Related Report
      2016 Annual Research Report
    • Invited
  • [Presentation] A new class of Gz-linked orphan GPCR in the brain’s central clock2017

    • Author(s)
      Masao Doi
    • Organizer
      Gordon Research Conference, Molecular Pharmacology
    • Place of Presentation
      Lucca, Italy
    • Year and Date
      2017-03-12
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] オーファンGPCRを介した生体リズム中枢の制御2017

    • Author(s)
      土居雅夫
    • Organizer
      第5回Academy of Aging and CArdiovascular-Diabetes Research
    • Place of Presentation
      東京
    • Year and Date
      2017-01-07
    • Related Report
      2016 Annual Research Report
    • Invited
  • [Presentation] Sleep Brain: Why do we need sleep?2017

    • Author(s)
      Masao Doi
    • Organizer
      The Japanese-American-German Frontiers of Science Symposium 2017
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] G-protein coupled receptors in the SCN: Timed Gi/Gz signaling sets the pace of the central clock2017

    • Author(s)
      Masao Doi
    • Organizer
      XV European Biological Rhythms Society Congress
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] 脳内中枢時計によるG蛋白質共役受容体を介した体温の概日性制御機構2017

    • Author(s)
      土居雅夫
    • Organizer
      次世代脳プロジェクト冬のシンポジウム
    • Related Report
      2017 Annual Research Report
    • Invited
  • [Presentation] マウスの体温の日内変動パターンを規定するG蛋白質共役受容体の解析2017

    • Author(s)
      土居雅夫、村井伊織、嶋谷寛之、岡村 均
    • Organizer
      第24回日本時間生物学会年会
    • Related Report
      2017 Annual Research Report
    • Invited
  • [Presentation] 生体リズム中枢における創薬標的分子探索2017

    • Author(s)
      土居雅夫、岡村 均
    • Organizer
      第39回日本生物学的精神医学会・第47回日本神経精神薬理学会
    • Related Report
      2017 Annual Research Report
    • Invited
  • [Presentation] 生物時計を標的にした創薬戦略-生体リズムを調節するための鍵はどこにあるのか?-2017

    • Author(s)
      土居雅夫、岡村 均
    • Organizer
      日本睡眠学会第42回定期学術集会
    • Related Report
      2017 Annual Research Report
    • Invited
  • [Presentation] 体内時計の中枢を調節するG蛋白質共役型受容体シグナル機構2017

    • Author(s)
      土居雅夫、岡村 均
    • Organizer
      第90回日本内分泌学会学術総会
    • Related Report
      2017 Annual Research Report
    • Invited
  • [Presentation] 高齢化社会における睡眠覚醒時間治療2016

    • Author(s)
      土居雅夫
    • Organizer
      第3回 Geroscience Initiative Japan
    • Place of Presentation
      仙台
    • Year and Date
      2016-11-26
    • Related Report
      2016 Annual Research Report
    • Invited
  • [Presentation] Does the SCN provide new space for time medicine? -GPCR signaling in the SCN-2016

    • Author(s)
      土居雅夫, 岡村均
    • Organizer
      第23回日本時間生物学会年会
    • Place of Presentation
      名古屋
    • Year and Date
      2016-11-12
    • Related Report
      2016 Annual Research Report
    • Invited
  • [Presentation] Circadian PER2 protein oscillations do not persist in cycloheximide-treated mouse embryonic fibroblasts in culture2016

    • Author(s)
      田井中元美, 土居雅夫, 井ノ上雄一, 岡村均
    • Organizer
      第23回日本時間生物学会年会
    • Place of Presentation
      名古屋
    • Year and Date
      2016-11-12
    • Related Report
      2016 Annual Research Report
  • [Presentation] Carbachol-induced biphasic phase-dependent phase-shift of core clock transcription rhythms in slice cultured suprachiasmatic nucleus2016

    • Author(s)
      Kumiko Dojo, Yoshiaki Yamaguchi, Jean-Michel Fustin, Masao Doi, Masaki Kobayashi and Hitoshi Okamura
    • Organizer
      第23回日本時間生物学会年会
    • Place of Presentation
      名古屋
    • Year and Date
      2016-11-12
    • Related Report
      2016 Annual Research Report
  • [Presentation] Gpr176 is an SCN-specific Gz-coupled orphan GPCR that controls circadian behavior.2016

    • Author(s)
      Masao Doi and Hitoshi Okamura
    • Organizer
      SRBR 2016, Society for research on biological rhythms
    • Place of Presentation
      Palm Harbor, FL, USA
    • Year and Date
      2016-05-22
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Gpr176: 体内時計の中枢を制御するGz共役型オーファンGPCR2016

    • Author(s)
      土居雅夫
    • Organizer
      第13回GPCR研究会
    • Place of Presentation
      東京
    • Year and Date
      2016-05-14
    • Related Report
      2016 Annual Research Report
    • Invited
  • [Presentation] Immunolocalization of Gpr176 and Vipr2 in the suprachiasmatic nucleus2016

    • Author(s)
      Iori Murai, Masao Doi, Hitoshi Okamura
    • Organizer
      第13回GPCR研究会
    • Place of Presentation
      東京
    • Year and Date
      2016-05-14
    • Related Report
      2016 Annual Research Report
  • [Presentation] Gpr176 is a Gz-linked orphan GPCR with constitutive cAMP-repressing activity.2016

    • Author(s)
      Kaoru Goto, Sumihiro Kunisue, Masao Doi, Hitoshi Okamura
    • Organizer
      第13回GPCR研究会
    • Place of Presentation
      東京
    • Year and Date
      2016-05-14
    • Related Report
      2016 Annual Research Report
  • [Presentation] 体内時計を調節するオーファンGPCRの同定 -Gz共役型GPCR-2016

    • Author(s)
      土居雅夫, 岡村均
    • Organizer
      第89回日本内分泌学会学術総会
    • Place of Presentation
      京都
    • Year and Date
      2016-04-23
    • Related Report
      2016 Annual Research Report
    • Invited
  • [Presentation] Differential regulation of the type I 3β-HSD gene expression by angiotensin II and potassium in human adrenocortical H295R cells2016

    • Author(s)
      鑓水大介, 土居雅夫, 岡村均
    • Organizer
      第89回日本内分泌学会学術総会
    • Place of Presentation
      京都
    • Year and Date
      2016-04-23
    • Related Report
      2016 Annual Research Report
  • [Presentation] 生活習慣病と体内時計2016

    • Author(s)
      土居雅夫
    • Organizer
      第113回日本内科学会講演会
    • Place of Presentation
      東京
    • Year and Date
      2016-04-15
    • Related Report
      2016 Annual Research Report
    • Invited
  • [Presentation] Clock Genes and Salt-Sensitive Hypertension: A new type of aldosterone synthesizing enzyme controlled by circadian clock and angiotensin II2016

    • Author(s)
      Masao Doi
    • Organizer
      Hypertension Summit 2016
    • Place of Presentation
      Kyoto, Japan
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] 視交叉上核ニューロンの概日振動を調節するGz共役型オーファン受容体の同定2015

    • Author(s)
      土居雅夫,岡村 均
    • Organizer
      BMB2015
    • Place of Presentation
      神戸
    • Year and Date
      2015-12-04
    • Related Report
      2015 Annual Research Report
    • Invited
  • [Presentation] Time-dependent recruitment of circadian negative regulators PER and CRY to the target gene promoter2015

    • Author(s)
      Hiroyuki Shimatani, Masao Doi, Hitoshi Okamura
    • Organizer
      BMB2015
    • Place of Presentation
      神戸
    • Year and Date
      2015-12-01
    • Related Report
      2015 Annual Research Report
  • [Presentation] Agonist-independent basal activity of Gz-linked orphan GPCR2015

    • Author(s)
      Genzui Setsu, Masao Doi, Hitoshi Okamura
    • Organizer
      BMB2015
    • Place of Presentation
      神戸
    • Year and Date
      2015-12-01
    • Related Report
      2015 Annual Research Report
  • [Presentation] 生体中枢時計を調律する新規オーファンGPCRの同定2015

    • Author(s)
      村井伊織,土居雅夫,岡村 均
    • Organizer
      第22回日本時間生物学会年会
    • Place of Presentation
      東京
    • Year and Date
      2015-11-22
    • Related Report
      2015 Annual Research Report
  • [Presentation] Identification of a new class of GPCR signaling that tunes the central clock2015

    • Author(s)
      Masao Doi, Hitoshi Okamura
    • Organizer
      第22回日本時間生物学会年会
    • Place of Presentation
      東京
    • Year and Date
      2015-11-21
    • Related Report
      2015 Annual Research Report
    • Invited
  • [Presentation] Identification of a new class of GPCR signalling that tunes the central clock2015

    • Author(s)
      Masao Doi and Hitoshi Okamura
    • Organizer
      Asian Forum on Chronobiology in 2015
    • Place of Presentation
      Sapporo, Japan
    • Year and Date
      2015-09-07
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] The orphan G-protein coupled receptor GPRS has an agonist-independent basal activity to reduce cAMP synthesis in a pertussis toxin-insensitive manner.2015

    • Author(s)
      Sumihiro Kunisue, Masao Doi, Hitoshi Okamura
    • Organizer
      第38回日本神経科学大会
    • Place of Presentation
      神戸
    • Year and Date
      2015-07-29
    • Related Report
      2015 Annual Research Report
  • [Presentation] Identification of a new class of GPCR signaling that tunes the central clock2015

    • Author(s)
      Sumihiro Kunisue, Masao Doi, Hitoshi Okamura
    • Organizer
      第32回内分泌代謝学サマーセミナー
    • Place of Presentation
      福岡
    • Year and Date
      2015-07-10
    • Related Report
      2015 Annual Research Report
  • [Presentation] Identification of Gz as a mediator of orphan GPCR constitutive activity2015

    • Author(s)
      Genzui Setsu, Masao Doi, Hitoshi Okamura
    • Organizer
      第32回内分泌代謝学サマーセミナー
    • Place of Presentation
      福岡
    • Year and Date
      2015-07-10
    • Related Report
      2015 Annual Research Report
  • [Presentation] Identification of a new class of GPCR signalling that tunes the central clock2015

    • Author(s)
      Masao Doi and Hitoshi Okamura
    • Organizer
      Gordon Research Conference, Chronobiology
    • Place of Presentation
      Girona, Spain
    • Year and Date
      2015-06-30
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research
  • [Book] 生体リズムと現代病-時計遺伝子を活用して治療する.2017

    • Author(s)
      土居 雅夫, 岡村 均:
    • Total Pages
      11
    • Publisher
      くすりをつくる研究者の仕事(京都大学大学院薬学研究科編)化学同人
    • Related Report
      2016 Annual Research Report
  • [Book] 生体リズム異常と原発性アルドステロン症2017

    • Author(s)
      岡村 均, 土居 雅夫
    • Total Pages
      3
    • Publisher
      原発性アルドステロン症診療マニュアル 改訂第2版 (成瀬光栄、平田結喜緒)診断と治療社
    • Related Report
      2016 Annual Research Report
  • [Book] 視交叉上核ニューロンの概日振動を調節するGz共役型オーファン受容体の同定 ブレインサイエンスレビュー20162016

    • Author(s)
      土居 雅夫
    • Total Pages
      7
    • Publisher
      クバプロ
    • Related Report
      2015 Annual Research Report
  • [Book] 哺乳類の生物時計 光と生命の事典(日本光生物協会編)2016

    • Author(s)
      土居 雅夫
    • Total Pages
      2
    • Publisher
      朝倉書店
    • Related Report
      2015 Annual Research Report
  • [Remarks] 京都大学大学院薬学研究科医薬創成情報科学専攻システムバイオロジー分野

    • URL

      http://systems-biology.pharm.kyoto-u.ac.jp/

    • Related Report
      2019 Annual Research Report 2018 Annual Research Report
  • [Remarks] 京都大学大学院薬学研究科医薬創成情報科学専攻システムバイオロジー分野

    • URL

      http://www.pharm.kyoto-u.ac.jp/system-biology/doimasao/

    • Related Report
      2017 Annual Research Report
  • [Remarks] マウスとハエに共通にみられる体温の日内リズムを制御する仕組み

    • URL

      http://www.kyoto-u.ac.jp/ja/research/research_results/2017/180214_1.html/

    • Related Report
      2017 Annual Research Report
  • [Remarks] 温度生物学

    • URL

      http://www.nips.ac.jp/thermalbio/research/research-MT2018-01.html

    • Related Report
      2017 Annual Research Report
  • [Remarks] 温度と体内時計を結ぶパスウェイ

    • URL

      http://www.nips.ac.jp/thermalbio/report/report2016_02.html

    • Related Report
      2016 Annual Research Report
  • [Remarks] 京都大学 大学院 薬学研究科 医薬創成情報科学専攻 システムバイオロジー分野

    • URL

      http://www.pharm.kyoto-u.ac.jp/system-biology/doimasao/index.html

    • Related Report
      2016 Annual Research Report
  • [Remarks]

    • URL

      http://www.pharm.kyoto-u.ac.jp/system-biology/doimasao/

    • Related Report
      2015 Annual Research Report

URL: 

Published: 2015-07-02   Modified: 2022-11-04  

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