| Budget Amount *help |
¥144,820,000 (Direct Cost: ¥111,400,000、Indirect Cost: ¥33,420,000)
Fiscal Year 2019: ¥25,610,000 (Direct Cost: ¥19,700,000、Indirect Cost: ¥5,910,000)
Fiscal Year 2018: ¥25,740,000 (Direct Cost: ¥19,800,000、Indirect Cost: ¥5,940,000)
Fiscal Year 2017: ¥25,350,000 (Direct Cost: ¥19,500,000、Indirect Cost: ¥5,850,000)
Fiscal Year 2016: ¥25,610,000 (Direct Cost: ¥19,700,000、Indirect Cost: ¥5,910,000)
Fiscal Year 2015: ¥42,510,000 (Direct Cost: ¥32,700,000、Indirect Cost: ¥9,810,000)
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| Outline of Final Research Achievements |
We found that hot and cold environments activate the neural circuits for negative emotion projecting from the paraventricular thalamic nucleus (PVT) to the nucleus accumbens, bed nucleus of the stria terminalis (BNST), and central amygdaloid nucleus (CeA). Real time measurement of neuronal activity was performed in the PVT. It was demonstrated that hot and cold environments enhanced noradrenergic neurotransmission in the BNST and that the activation of neuronal projections from the BNST to the CeA induced negative emotion. An evaluation system for behavioral thermoregulation in mice was developed. It was shown that local temperature is elevated in the epileptogenic brain region and that TRPV4, which senses brain temperature, senses the elevated temperature in the epileptogenic region and exacerbates epilepsy. We have established a method for monitoring the temperature distribution in brain slice preparations by injecting temperature-sensitive fluorescent polymers.
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