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Multidisciplinary studies of the effects of low-fluence particle radiations on animal individuals and adaptation of living organisms

Planned Research

Project Area"LIVING IN SPACE" - Integral Understanding of life-regulation mechanism from "SPACE"
Project/Area Number 15H05944
Research Category

Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)

Allocation TypeSingle-year Grants
Review Section Complex systems
Research InstitutionNational Institutes for Quantum and Radiological Science and Technology

Principal Investigator

Nenoi Mitsuru  国立研究開発法人量子科学技術研究開発機構, 本部 安全管理部, 部長(任常) (10164659)

Co-Investigator(Kenkyū-buntansha) 王 冰  国立研究開発法人量子科学技術研究開発機構, 放射線医学総合研究所 放射線影響研究部, グループリーダー(定常) (10300914)
勝部 孝則  国立研究開発法人量子科学技術研究開発機構, 放射線医学総合研究所 放射線影響研究部, 主幹研究員(定常) (10311375)
藤森 亮  国立研究開発法人量子科学技術研究開発機構, 放射線医学総合研究所 放射線障害治療研究部, グループリーダー(定常) (50314183)
丸山 耕一  国立研究開発法人量子科学技術研究開発機構, 高度被ばく医療センター 福島再生支援研究部, 主任研究員(定常) (70349033)
中島 徹夫  国立研究開発法人量子科学技術研究開発機構, 放射線医学総合研究所 放射線影響研究部, グループリーダー(定常) (80237271)
鈴木 健之  国立研究開発法人宇宙航空研究開発機構, 有人宇宙技術部門, 宇宙航空プロジェクト研究員 (20726442)
永松 愛子  国立研究開発法人宇宙航空研究開発機構, 有人宇宙技術部門, 研究開発員 (00421868)
Project Period (FY) 2015-06-29 – 2020-03-31
Project Status Completed (Fiscal Year 2019)
Budget Amount *help
¥95,030,000 (Direct Cost: ¥73,100,000、Indirect Cost: ¥21,930,000)
Fiscal Year 2019: ¥16,640,000 (Direct Cost: ¥12,800,000、Indirect Cost: ¥3,840,000)
Fiscal Year 2018: ¥16,640,000 (Direct Cost: ¥12,800,000、Indirect Cost: ¥3,840,000)
Fiscal Year 2017: ¥16,640,000 (Direct Cost: ¥12,800,000、Indirect Cost: ¥3,840,000)
Fiscal Year 2016: ¥16,640,000 (Direct Cost: ¥12,800,000、Indirect Cost: ¥3,840,000)
Fiscal Year 2015: ¥28,470,000 (Direct Cost: ¥21,900,000、Indirect Cost: ¥6,570,000)
Keywords宇宙放射線 / ストレス / ゲノム損傷 / 感受性修飾 / 鉄イオン線 / 小核試験 / 染色体異常 / 放射線防護物質 / ゲノム不安定性 / マウス / メダカ
Outline of Final Research Achievements

Particle radiation is one of the important risk factors for the human beings in their long-term residence in the space. By focusing on “collapse” and “plasticity” of the genome which are closely related to the tumorigenicity by some radiations and chemical reagents, we investigated the risk of the particle radiations by applying the in-vivo animal models that was recently updated for unknown human hazards. Exposure to the particle radiations (iron ion beams) at the low fluence could induce genomic instability, the condition of which is comparable to the low-dose conventional X-rays. In addition, our results suggested that human psychological factors are possible enhancing factors in the tumorigenicity which is primarily induced by various genotoxic reagents.

Academic Significance and Societal Importance of the Research Achievements

一般に発がんの原因として日常のストレス(複合要因)の寄与が無視できないと考えられる。本研究を通じて確立されたモデル動物の実験系は宇宙銀河放射線の生体影響の評価に役立つことが示された。今後これらは、ヒトに対する放射線防護剤の検定や生活習慣等によるストレスの評価に有用である。動物の個体レベルの高次なストレスと細胞の遺伝子染色体損傷の修復過程との関わりが示唆された一方、メカニズムの詳細は未だ明らかでない。今後、個体の生理的応答と細胞のより詳細な分子的関連を探索し、その成果を人為的ながん予防の開発に結びつけるアプローチによって、ゲノム損傷などが原因となる発がんの抑制に貢献することが期待される。

Report

(6 results)
  • 2019 Annual Research Report   Final Research Report ( PDF )
  • 2018 Annual Research Report
  • 2017 Annual Research Report
  • 2016 Annual Research Report
  • 2015 Annual Research Report
  • Research Products

    (70 results)

All 2020 2019 2018 2017 2016 2015 Other

All Journal Article (21 results) (of which Int'l Joint Research: 18 results,  Peer Reviewed: 20 results,  Open Access: 15 results,  Acknowledgement Compliant: 2 results) Presentation (47 results) (of which Int'l Joint Research: 21 results,  Invited: 13 results) Book (1 results) Remarks (1 results)

  • [Journal Article] Aspergillus niger Spores Are Highly Resistant to Space Radiation2020

    • Author(s)
      Cortesao Marta、de Haas Aram、Unterbusch Rebecca、Fujimori Akira、Schutze Tabea、Meyer Vera、Moeller Ralf
    • Journal Title

      Frontiers in Microbiology

      Volume: 11

    • DOI

      10.3389/fmicb.2020.00560

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Diallyl Disulfide Mitigates DNA Damage and Spleen Tissue Effects After Irradiation2019

    • Author(s)
      Nakajima Tetsuo、Vares Guillaume、Ninomiya Yasuharu、Wang Bing、Katsube Takanori、Tanaka Kaoru、Maruyama Kouichi、Nenoi Mitsuru
    • Journal Title

      Medical Science Monitor

      Volume: 25 Pages: 8920-8927

    • DOI

      10.12659/msm.917207

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Monoenergetic 290 MeV/n carbon-ion beam biological lethal dose distribution surrounding the Bragg peak2019

    • Author(s)
      Buglewicz Dylan J.、Banks Austin B.、Hirakawa Hirokazu、Fujimori Akira、Kato Takamitsu A.
    • Journal Title

      Scientific Reports

      Volume: 9 Issue: 1 Pages: 6157-6157

    • DOI

      10.1038/s41598-019-42600-4

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Reduction of Delayed Homologous Recombination by Induction of Radioadaptive Response in RaDR-GFP Mice (Yonezawa Effect): An Old Player with A New Role2019

    • Author(s)
      Cuihua Liu , Hirokazu Hirakawa , Kaoru Tanaka , Fazliana Mohd saaya , Mitsuru Nenoi , Akira Fujimori , Bing Wang
    • Journal Title

      Dose-Response

      Volume: 17(1) Issue: 1

    • DOI

      10.1177/1559325819833840

    • Related Report
      2019 Annual Research Report 2018 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] A Small Fish Model for Quantitative Analysis of Radiation Effects Using Visualized Thymus Responses in GFP Transgenic Medaka2019

    • Author(s)
      Maruyama Kouichi、Iwanami Norimasa、Maruyama-Hayakawa Takako、Doi Kazutaka、Wang Bing
    • Journal Title

      International Journal of Radiation Biology

      Volume: 未定 Issue: 8 Pages: 1-16

    • DOI

      10.1080/09553002.2019.1589019

    • Related Report
      2019 Annual Research Report 2018 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Radiobiological Characterization of Canine Malignant Melanoma Cell Lines with Different Types of Ionizing Radiation and Efficacy Evaluation with Cytotoxic Agents2019

    • Author(s)
      Yoshikawa Hiroto、Sunada Shigeaki、Hirakawa Hirokazu、Fujimori Akira、Elmegerhi Suad、Leary Del、Kato Takamitsu
    • Journal Title

      International Journal of Molecular Sciences

      Volume: 20 Issue: 4 Pages: 841-841

    • DOI

      10.3390/ijms20040841

    • Related Report
      2019 Annual Research Report 2018 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] DNA Repair Deficient Chinese Hamster Ovary Cells Exhibiting Differential Sensitivity to Charged Particle Radiation under Aerobic and Hypoxic Conditions2018

    • Author(s)
      Cartwright Ian M.、Su Cathy、Haskins Jeremy S.、Salinas Victoria A.、Sunada Shigeaki、Yu Hao、Uesaka Mitsuru、Hirakawa Hirokazu、Chen David J.、Fujimori Akira、Kato Takamitsu A.
    • Journal Title

      International Journal of Molecular Sciences

      Volume: 19 Issue: 8 Pages: 2228-2228

    • DOI

      10.3390/ijms19082228

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Apoptosis Induction by Iron Radiation via Inhibition of Autophagy in Trp53+/- Mouse Testes: Is Chronic Restraint-Induced Stress a Modifying Factor?2018

    • Author(s)
      Li Hongyan、Wang Bing、Zhang Hong、Katsube Takanori、Xie Yi、Gan Lu
    • Journal Title

      International Journal of Biological Sciences

      Volume: 14 Issue: 9 Pages: 1109-1121

    • DOI

      10.7150/ijbs.22805

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Increased Hematopoietic Stem Cells/Hematopoietic Progenitor Cells Measured as Endogenous Spleen Colonies in Radiation-Induced Adaptive Response in Mice (Yonezawa Effect)2018

    • Author(s)
      Wang Bing、Tanaka Kaoru、Ninomiya Yasuharu、Maruyama Kouichi、Var?s Guillaume、Katsube Takanori、Murakami Masahiro、Liu Cuihua、Fujimori Akira、Fujita Kazuko、Liu Qiang、Eguchi-Kasai Kiyomi、Nenoi Mitsuru
    • Journal Title

      Dose-Response

      Volume: 16 Issue: 3 Pages: 1-10

    • DOI

      10.1177/1559325818790152

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Palmitoyl ascorbic acid 2-glucoside has the potential to protect mammalian cells from high-LET carbon-ion radiation2018

    • Author(s)
      Alexis H. Haskins, Dylan J. Buglewicz, Hirakawa Hirokazu, Akira Fujimori, Yasushi Aizawa, Takamitsu A. Kato
    • Journal Title

      Scientific Reports

      Volume: 8(1) Issue: 1 Pages: 1-7

    • DOI

      10.1038/s41598-018-31747-1

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Histone Deacetylase Inhibitor induced Radiation Sensitization Effects2018

    • Author(s)
      Ariungerel Gerelchuluun, Junko Maeda, Akira Fujimori et al.
    • Journal Title

      Journal of Molecular Sciences

      Volume: 19(2) Issue: 2 Pages: 496-496

    • DOI

      10.3390/ijms19020496

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] 微生物学的生体モデルを用いた銀河宇宙放射線の生物効果に関する研究2018

    • Author(s)
      藤森 亮, Kristina Beblo-Vranesevic, Stefan Leuko, Ralf Moeller
    • Journal Title

      生体の科学

      Volume: 69 Pages: 157-161

    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Journal Article] Investigation of the relative biological effectiveness and uniform isobiological killing effects of irradiation with a clinical carbon SOBP beam on DNA repair deficient CHO cells.2017

    • Author(s)
      S.Sunada, I.M. Cartwright, H.Hirakawa, A.Fujimori, M.Uesaka and T.A. Kato
    • Journal Title

      Oncology Letters

      Volume: 13 Issue: 6 Pages: 4911-4916

    • DOI

      10.3892/ol.2017.6072

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Low and High LET Ionizing Radiation-Induced Delayed Homologous Recombination Persists for Two Weeks Before Resolving.2017

    • Author(s)
      C.P. Allen, H.Hirakawa, N.Izumi-Nakajima, S.Moore, J.Nie, N.Sharma, M.Sugiura, Y.Hoki, R.Araki, M.Abe, R.Okayasu, A.Fujimori and J.A.Nickoloff
    • Journal Title

      Radiation Research

      Volume: 188 Issue: 1 Pages: 82-93

    • DOI

      10.1667/rr14748.1

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] STARLIFE-An International Campaign to Study the Role of Galactic Cosmic Radiation in Astrobiological Model Systems.2017

    • Author(s)
      R.Moeller, M. Raguse, S. Leuko, T. Berger, C.E. Hellweg, A. Fujimori, Ryuichi Okayasu, Gerda Horneck
    • Journal Title

      Astrobiology

      Volume: 17 Issue: 2 Pages: 101-109

    • DOI

      10.1089/ast.2016.1571

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Cryptoendolithic Antarctic Black Fungus Cryomyces antarcticus Irradiated with2017

    • Author(s)
      Claudia Pacelli, Ralf Moeller, Akira Fujimori et al.
    • Journal Title

      Frontiers in Microbiology

      Volume: 8 Pages: 2002-2002

    • DOI

      10.3389/fmicb.2017.02002

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Oxygen Enhancement Ratio in Radiation-Induced Initial DSBs by an Optimized Flow Cytometry-based Gamma-H2AX Analysis in A549 Human Cancer Cells.2017

    • Author(s)
      S. Sunada, H. Hirakawa, A. Fujimori, M. Uesaka, R. Okayasu
    • Journal Title

      Radiation Research

      Volume: 188 Issue: 5 Pages: 591-594

    • DOI

      10.1667/rr14824.1

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Research and development of radioprotective agents: A mini-review.2017

    • Author(s)
      Fazliana Mohd Saaya, Takanori Katsube, Yi Xie, Kaoru Tanaka, Kazuko Fujita, Bing Wang
    • Journal Title

      International Journal of Radiology

      Volume: 4 Issue: 2 Pages: 128-138

    • DOI

      10.17554/j.issn.2313-3406.2017.04.41

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Investigation of the relative biological effectiveness and uniform isobiological killing effects of irradiation with a clinical carbon SOBP beam on DNA repair deficient CHO cells.2017

    • Author(s)
      Shigeaki Sunada, Ian M. Cartwright, Hirokazu Hirakawa, Akira Fujimori, Mitsuru Uesaka and Takamitsu Kato
    • Journal Title

      Oncology Letters

      Volume: 印刷中

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] Effects of chronic restraint-induced stress on radiation-induced chromosomal aberrations in mouse splenocytes.2016

    • Author(s)
      T. Katsube, B. Wang, K. Tanaka, Y. Ninomiya, G. Vares, T. Kawagoshi, N. Shiomi, Y. Kubota, Q. Liu, A. Morita, T. Nakajima, and M. Nenoi
    • Journal Title

      Mutation Research/Genetic Toxicology and Environmental Mutagenesis

      Volume: 813 Pages: 18-26

    • DOI

      10.1016/j.mrgentox.2016.11.005

    • Related Report
      2017 Annual Research Report 2016 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Revisiting the health effect of psychological stress: Its influence on susceptibility to ionizing radiation. A mini-review.2016

    • Author(s)
      Bing Wang, Takanori Katsube, Nasrin Begum, and Mitsuru Nenoi
    • Journal Title

      Journal of Radiation Research

      Volume: 57 Issue: 4 Pages: 325-335

    • DOI

      10.1093/jrr/rrw035

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
  • [Presentation] メダカ放射線適応応答効果の検証2020

    • Author(s)
      丸山耕一
    • Organizer
      日本動物学会関東支部大会
    • Related Report
      2019 Annual Research Report
  • [Presentation] Differences in DNA damage response to high-LET ionizing radiation between human and rodent cells2019

    • Author(s)
      勝部孝則、村上正弘、LIU Qiang、XIE Yi、王冰
    • Organizer
      第42回日本分子生物学会年会
    • Related Report
      2019 Annual Research Report
  • [Presentation] Radiation-protective abilities of DADS, a garlic oil component in X-ray irradiated mice2019

    • Author(s)
      Tetsuo Nakajima, Yasuharu Ninomiya and Mitsuru Nenoi
    • Organizer
      The 7th International Conference on Food Factors
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research
  • [Presentation] FISH analysis of chromosomal aberrations in splenocytes of Trp53-heterozygous mice exposed to both chronic restraint-induced stress and Fe-particle irradiation2019

    • Author(s)
      勝部孝則, 王冰, 田中薫, 二宮康晴, 平川博一, 劉翠華, 丸山耕一, Guillaume Vares, Qiang Liu, 中島徹夫, 藤森亮, 根井充
    • Organizer
      第62回日本放射線影響学会大会
    • Related Report
      2019 Annual Research Report
  • [Presentation] Biological effects of high LET heavy ions in human blood lymphocytes and mouse cells2019

    • Author(s)
      P. Hande, D. Zeegers, S. Venkatesan, M. Seah, P. Velmurugan, S. Koh, S. Sethu, M. Jayapal, B. Banerjee, H. Hirakawa, C. Liu, R. Okayasu, A. Fujimori
    • Organizer
      第62回日本放射線影響学会大会
    • Related Report
      2019 Annual Research Report
    • Invited
  • [Presentation] Modification of radiation effects by psychosocial stress using syngenic tumor-grafted mice2019

    • Author(s)
      Yasuharu Ninomiya, Tetsuo Nakajima
    • Organizer
      第62回日本放射線影響学会大会
    • Related Report
      2019 Annual Research Report
  • [Presentation] 中性子線被ばく影響評価と食品由来防護剤探索2019

    • Author(s)
      中島徹夫、二宮康晴、丸山耕一、小川原亮、須田充、根井充
    • Organizer
      第33回宇宙生物科学会
    • Related Report
      2019 Annual Research Report
  • [Presentation] Effects from Chronic Restraint-Induced Stress and Total Body Fe Irradiation on the Hematopoietic System in Trp53-Heterozygous Mice2019

    • Author(s)
      田中薫, 王冰, 勝部孝則, 二宮康晴, 平川博一, 劉翠華, 丸山耕一, Guillaume Vares, Qiang Liu, 中島徹夫, 藤森亮, 根井充
    • Organizer
      第33回宇宙生物科学会
    • Related Report
      2019 Annual Research Report
  • [Presentation] Chromosomal aberrations induced in Trp53-heterozygous mice exposed to both chronic restraint-induced stress and Fe-particle irradiation2019

    • Author(s)
      勝部孝則, 王冰, 田中薫, 二宮康晴, 平川博一, 劉翠華, 丸山耕一, Guillaume Vares, Qiang Liu, 中島徹夫, 藤森亮, 根井充
    • Organizer
      第33回宇宙生物科学会
    • Related Report
      2019 Annual Research Report
  • [Presentation] New Findings in Characterization of Radioadaptive Response in Mice (Yonezawa Effect)2019

    • Author(s)
      王冰, 劉翠華, 田中薫, 勝部孝則, 平川博一, 二宮康晴, 丸山耕一, 村上正弘, 藤田和子, Qiang Liu, 藤森亮, 根井充
    • Organizer
      第33回宇宙生物科学会
    • Related Report
      2019 Annual Research Report
  • [Presentation] Bioindocators of heavy Ion exposures in human lymphocytes: use of molecular cytogenetic techniques2019

    • Author(s)
      Dimphy Zeegers, Shriram Venkatesan, Birendranath Banerjee, Swaminathan Sethu, Manikandan Jayapal, Akira Fujimori, Ryuichi Okayasu, Prakash Hande
    • Organizer
      第33回宇宙生物科学会
    • Related Report
      2019 Annual Research Report
    • Invited
  • [Presentation] 放射線に誘発されたマウス胸腺腫とゲノム不安定性2019

    • Author(s)
      藤森亮、劉翠華、平川博一、王冰、勝部孝則 、中島徹夫 、二宮康晴、田中薫 、根井充
    • Organizer
      第33回宇宙生物科学会
    • Related Report
      2019 Annual Research Report
  • [Presentation] Characterization of Radioadaptive Response in a Mouse Model (Yonezawa Effect)2019

    • Author(s)
      Bing Wang, Cuihua Liu, Kaoru Tanaka, Takanori Katsube, Hirokazu Hirakawa, Yasuharu Ninomiya, Kouichi Maruyama, Masahiro Murakami, Kazuko Fujita, Qiang Liu, Akira Fujimori, Mitsuru Nenoi
    • Organizer
      International Congress of Radiation Research
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Effects of chronic restraint-induced stress and Fe-particle irradiation on induction of chromosomal aberrations in Trp53-heterozygous mice2019

    • Author(s)
      Takanori Katsube, Bing Wang, Kaoru Tanaka, Yasuharu Ninomiya, Cuihua Liu, Hirokazu Hirakawa, Kouichi Maruyama, Guillaume Vares, Qiang Liu, Tetsuo Nakajima, Akira Fujimori, Mitsuru Nenoi
    • Organizer
      International Congress of Radiation Research
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Psychosocial stress promotes radiation-induced acute damage in mice2019

    • Author(s)
      Tetsuo Nakajima, Yasuharu Ninomiya, Keiko Unno, Takamitsu Morioka, Mayumi Nishimura, Mitsuru Nenoi, Shizuko Kakinuma
    • Organizer
      International Congress of Radiation Research
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research
  • [Presentation] FISH analysis of chromosomal aberrations induced in Trp53-heterozygous mice exposed to both chronic restraint-induced stress and Fe-particle irradiation2019

    • Author(s)
      Takanori Katsube, Bing Wang, Kaoru Tanaka, Yasuharu Ninomiya, Hirokazu Hirakawa, Cuihua Liu, Kouichi Maruyama, Guillaume Vares, Qiang Liu, Tetsuo Nakajima, Akira Fujimori, Mitsuru Nenoi
    • Organizer
      Workshop of Radiation Medicine and Protection", Workshop of Radiation Medicine and Protection
    • Related Report
      2019 Annual Research Report
    • Invited
  • [Presentation] New Progress in Characterization of Radioadaptive Response in a Mouse Model (Yonezawa Effect)2019

    • Author(s)
      Bing Wang, Cuihua Liu, Kaoru Tanaka, Takanori Katsube, Hirokazu Hirakawa, Yasuharu Ninomiya, Kouichi Maruyama, Masahiro Murakami, Kazuko Fujita, Qiang Liu, Akira Fujimori, Mitsuru Nenoi
    • Organizer
      Workshop of Radiation Medicine and Protection
    • Related Report
      2019 Annual Research Report
    • Invited
  • [Presentation] DIALLYL DISULFIDE AMELIORATES RADIATION DAMAGE IN CELLS AND MICE2019

    • Author(s)
      Tetsuo Nakajima, Guillaume Vares, Yasuharu Ninomiya, Bing Wang, Takanori Katsube, Kaoru Tanaka, Kouichi Maruyama, and Mitsuru Nenoi
    • Organizer
      国際ガーリックシンポジウム
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] FISH analysis of chromosomal aberrations induced by accelerated heavy iron particles in mouse splenocytes2018

    • Author(s)
      Takanori Katsube, Bing Wang, Kaoru Tanaka, Yasuharu Ninomiya, Hirokazu Hirakawa, Cuihua Liu, Kouichi Maruyama, Guillaume Varès, Tetsuo Nakajima, Akira Fujimori, Mitsuru Nenoi
    • Organizer
      The 42nd COSPAR Scientific Assembly
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Induction of genotoxicity by accelerated heavy iron particles in the hematopoietic system in mice2018

    • Author(s)
      Bing Wang, Kaoru Tanaka, Takanori Katsube, Yasuharu Ninomiya, Hirokazu Hirakawa, Cuihua Liu, Kouichi Maruyama, Guillaume Vares, Tetsuo Nakajima, Akira Fujimori, Mitsuru Nenoi
    • Organizer
      The 42nd COSPAR Scientific Assembly
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research
  • [Presentation] ヒト骨髄由来幹細胞を用いた中性子線被ばく影響評価と防護剤効果2018

    • Author(s)
      中島徹夫、二宮康晴、丸山耕一、小川原亮、須田充、根井充
    • Organizer
      日本放射線影響学会第61回大会
    • Related Report
      2018 Annual Research Report
  • [Presentation] ジアリルジスルフィドの放射線防護効果と宇宙環境での利用について2018

    • Author(s)
      中島 徹夫, Guillaume Vares, 二宮 康晴, 王 冰, 勝部 孝則, 田中 薫, 劉 翠華, 平川 博一, 丸山 耕一, 藤森 亮, 根井 充
    • Organizer
      第72回日本栄養・食糧学会大会
    • Related Report
      2018 Annual Research Report
  • [Presentation] Changes in free amino acids in mice exposed to X-ray or Fe-ion radiation.2017

    • Author(s)
      Tetsuo Nakajima, Guillaume Vares, Yasuharu Ninomiya, Bing Wang, Takanori Katsube, Kaoru Tanaka, Cuihua Liu, Hirokazu Hirakawa, Kouichi Maruyama, Akira Fujimori, Mitsuru Nenoi
    • Organizer
      The 7th International Society of Radiation Neurobiology Conference
    • Place of Presentation
      Yuzawa, Japan
    • Year and Date
      2017-02-09
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Visualization of In Vivo DNA damage responses to galactic cosmic radiation.2017

    • Author(s)
      A.Fujimori, H.Hirakawa, C.Liu
    • Organizer
      The 5th International Symposium on Space Radiation and Particle Radiotherapy
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Comparative exploration of biomarkers in mice exposed to X-ray or Fe-ion radiation2017

    • Author(s)
      T.Nakajima, G.Vares, Y.Ninomiya, B.Wang, T.Katsube, K.Tanaka, C.Liu, H.Hirakawa, K.Maruyama, A.Fujimori
    • Organizer
      The 56th Annual Conference of the particle thrapy co-operative group
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Relative Effectiveness of Heavy Ion Irradiations from Accelerated Iron-56 Particles for Induction of Genotoxicity in the Hematopoietic System in Mice: Hematological Abnormality in the Peripheral Blood and Residual Damage in the Bone Marrow Erythrocytes (Part II).2017

    • Author(s)
      B.Wang, K.Tanaka, T.Katsube, Y.Ninomiya, H.Hirakawa, C.Liu, K.Maruyama, G.Vares, T.Nakajima, A.Nagamatsu, A.Fujimori, M.Nenoi
    • Organizer
      The 63rd Annual International Meeting, Radiation Research Society, Radiation Research Society
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] FISH analysis of chromosomal aberrations in mouse splenocytes following total body irradiation with heavy ions (iron-56 ions) and X-rays.2017

    • Author(s)
      T.Katsube, B.Wang, K.Tanaka, Y.Ninomiya, H.Hirakawa, C.Liu, K.Maruyama, G.Vares, T.Nakajima, A.Nagamatsu, A.Fujimori, M.Nenoi
    • Organizer
      The 63rd Annual International Meeting, Radiation Research Society, Radiation Research Society
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] X線照射後の生体応答に対する低酸素環境の役割に関する研究2017

    • Author(s)
      劉翠華, 平川博一, 藤森亮, 平山亮一
    • Organizer
      日本放射線影響学会第60回大会
    • Related Report
      2017 Annual Research Report
  • [Presentation] Differences between photon and particle radiations in terms of their biological effects: Evaluation and protection.2017

    • Author(s)
      T.Nakajima,
    • Organizer
      第55回日本生物物理学会年会 シンポジウム 「Frontiers in radiation biophysics utilizing quantum beam technologies」
    • Related Report
      2017 Annual Research Report
    • Invited
  • [Presentation] 宇宙滞在における放射線防護のためのバイオマーカーと防護剤の探索2017

    • Author(s)
      中島徹夫
    • Organizer
      日本放射線影響学会第60回大会 シンポジウム「宇宙における放射線防護を考える -影響の多面性と評価-」
    • Related Report
      2017 Annual Research Report
    • Invited
  • [Presentation] ヒト細胞の高LET放射線に対する応答におけるArtemisとXRCC4の機能2017

    • Author(s)
      勝部孝則, 劉強, Xie Yi, 王冰
    • Organizer
      第40回日本分子生物学会年会・第90回日本生化学会大会
    • Related Report
      2017 Annual Research Report
  • [Presentation] 鉄イオン線とX線によるマウス脾細胞染色体異常誘導のFISH法による比較2017

    • Author(s)
      勝部孝則, 王冰, 田中薫, 二宮康晴, 平川博一, 劉翠華, 丸山耕一, Guillaume Vares, 中島徹夫, 鈴木健之, 永松愛子, 藤森亮, 根井充
    • Organizer
      日本放射線影響学会第60回大会
    • Related Report
      2017 Annual Research Report
  • [Presentation] Induction of Genotoxicity by Accelerated Iron Particles in Mouse Hematopoietic System.2017

    • Author(s)
      B.Wang, K.Tanaka, T.Katsube, Y.Ninomiya, H.Hirakawa, C.Liu, K.Maruyama, T.Nakajima, A.Fujimori, M.Nenoi
    • Organizer
      日本放射線影響学会第60回大会
    • Related Report
      2017 Annual Research Report
  • [Presentation] 高脂肪餌で飼育した母親から得られた仔マウスの放射線感受性I.照射300日目までの結果2017

    • Author(s)
      田中薫, 王冰, 勝部孝則, 村上正弘, 藤田和子, 森岡孝満, 西村まゆみ, 柿沼志津子
    • Organizer
      日本放射線影響学会第60回大会
    • Related Report
      2017 Annual Research Report
  • [Presentation] Does total-body low dose irradiation induce Alzheimer’s disease-like pathogenesis in mice?2017

    • Author(s)
      B.Wang, K.Tanaka, B.Ji, M.Ono, Y.Fang, Y.Ninomiya, K.Maruyama, N.Nakajima, N.Begum, M.Higuchi, A.Fujimori, Y.Uehara, T.Nakajima, T.Suhara, T.Ono, M.Nenoi
    • Organizer
      National Institute for Radiological Protection, Chinese Center for Disease Control and Prevention
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Reduction of high-dose-radiation-induced delayed genotoxic effects by radioadaptive response and mild diet restriction in mice.2017

    • Author(s)
      B.Wang, K.Tanaka, T.Katsube, Y.Ninomiya, M.Nenoi
    • Organizer
      Workshop of Radiation Medicine and Protection. Institute of Radiation Medicine, Chinese Academy of Medical Science
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Most hydrogen peroxide-induced histone H2AX phosphorylation is mediated by ATR and is not dependent on DNA double-strand breaks2017

    • Author(s)
      T.Katsube, M.Mori, H.Tsuji, T.Shiomi, B.Wang, Q.Liu, M.Nenoi, M.Onoda
    • Organizer
      National Institute for Radiological Protection, Chinese Center for Disease Control and Prevention
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] A study on relative effectiveness of heavy ion irradiations from accelerated iron-56 particles for induction of chromosomal aberrations in mouse splenocytes2017

    • Author(s)
      T.Katsube, B.Wang, K.Tanaka, Y.Ninomiya, H.Hirakawa, C.Liu, K.Maruyama, G.Vares, T.Nakajima, A.Nagamatsu, A.Fujimori, M.Nenoi
    • Organizer
      Workshop of Radiation Medicine and Protection. Institute of Radiation Medicine, Chinese Academy of Medical Science
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] マウス造血組織の遺伝毒性誘導に対する重粒子線(鉄イオン線)照射の相対的効果2016

    • Author(s)
      田中薫, 王冰, 勝部孝則, 二宮康晴, 平川博一, 劉翠華, 丸山耕一, Guillaume Vares, 中島徹夫, 永松愛子, 藤森亮, 根井充
    • Organizer
      第59回日本放射線影響学会大会
    • Place of Presentation
      広島県、広島市
    • Year and Date
      2016-10-26
    • Related Report
      2016 Annual Research Report
  • [Presentation] 放射線誘発マウス胸腺腫とゲノム不安定性2016

    • Author(s)
      劉翠華、平川博一、王冰、勝部孝則、中島徹夫、二宮康晴、田中薫、根井充、藤森亮
    • Organizer
      第59回日本放射線影響学会大会
    • Place of Presentation
      広島県、広島市
    • Year and Date
      2016-10-26
    • Related Report
      2016 Annual Research Report
  • [Presentation] Relative Effectiveness of Heavy Ion Irradiations from Accelerated Iron-56 Particles for Induction of Genotoxicity in the Hematopoietic System in Mice.2016

    • Author(s)
      Bing Wang, Kaoru Tanaka, Takanori Katsube, Yasuharu Ninomiya, Hirokazu Hirakawa, Cuihua Liu, Kouichi Maruyama, Guillaume Vares, Tetsuo Nakajima, Aiko Nagamatsu, Akira Fujimori, Mitsuru Nenoi
    • Organizer
      The 62th annual meeting, Radiation Research Society
    • Place of Presentation
      Waikoloa, Hawaii, USA
    • Year and Date
      2016-10-16
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] A study on relative effectiveness of heavy ion irradiations from accelerated iron-56 particles for induction of chromosomal aberrations in mouse splenocytes.2016

    • Author(s)
      Takanori Katsube, Bing Wang, Kaoru Tanaka, Yasuharu Ninomiya, Hirokazu Hirakawa, Cuihua Liu, Kouichi Maruyama, Guillaume Vares, Tetsuo Nakajima, Aiko Nagamatsu, Akira Fujimori, Mitsuru Nenoi
    • Organizer
      The 62th annual meeting, Radiation Research Society
    • Place of Presentation
      Waikoloa, Hawaii, USA
    • Year and Date
      2016-10-16
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Revisiting the health effect of psychological stress: Time to focus on its influence on susceptibility to ionizing radiation.2016

    • Author(s)
      Bing Wang, Takanori Katsube, Nasrin Begum, Mitsuru Nenoi.
    • Organizer
      Workshop of Radiation Medicine and Protection. The Institute of Radiation Medicine, Chinese Academy of Medical Science
    • Place of Presentation
      Tianjin, China
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Effects of chronic restraint-induced stress on radiation-induced chromosomal aberrations in mouse splenocytes,2016

    • Author(s)
      Takanori Katsube, Bing Wang, Kaoru Tanaka, Yasuharu Ninomiya, Guillaume Vares, Taiki Kawagoshi, Naoko Shiomi, Yoshihisa Kubota, Qiang Liu, Akinori Morita, Tetsuo Nakajima, Mitsuru Nenoi
    • Organizer
      Workshop of Radiation Medicine and Protection. The Institute of Radiation Medicine, Chinese Academy of Medical Science
    • Place of Presentation
      Tianjin, China
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] 放射線誘発胸腺腫とゲノム不安定性2016

    • Author(s)
      平川博一、劉翠華、藤森亮、根井充
    • Organizer
      「宇宙に生きる」若手の会ワークショップ
    • Place of Presentation
      東京
    • Related Report
      2015 Annual Research Report
  • [Presentation] Effects from chronic restraint-induced stress and total body irradiation on the hematopoietic system in mice.2015

    • Author(s)
      Bing Wang, Kaoru Tanaka, Takanori Katsube, Yasuharu Ninomiya, Guillaume Vares, Qiang Liu, Akinori Morita, Tetsuo Nakajima, and Mitsuru Nenoi
    • Organizer
      The 61st Annual Meeting of the Radiation Research Society
    • Place of Presentation
      Weston, Florida, USA
    • Year and Date
      2015-09-19
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Effects from chronic restraint-induced stress on radiation-induced chromosomal aberrations in mouse splenocytes.2015

    • Author(s)
      Takanori Katsube, Bing Wang, Kaoru Tanaka, Yasuharu Ninomiya, Guillaume Varès, Qiang Liu, Akinori Morita, Tetsuo Nakajima, and Mitsuru Nenoi
    • Organizer
      The 61st Annual Meeting of the Radiation Research Society
    • Place of Presentation
      Weston, Florida, USA
    • Year and Date
      2015-09-19
    • Related Report
      2015 Annual Research Report
  • [Book] "Radiation-Induced Reactions in The Liver ─ Modulation of Radiation Effects by Lifestyle-Related Factors─" in "International Journal of Molecular Sciences"2018

    • Author(s)
      Tetsuo Nakajima, Yasuharu Ninomiya and Mitsuru Nenoi
    • Total Pages
      13
    • Publisher
      Multidisciplinary Digital Publishing Institute
    • Related Report
      2018 Annual Research Report
  • [Remarks] 宇宙に生きる 宇宙からひも解く新たな生命制御機構の統合的理解

    • URL

      http://living-in-space.jp/

    • Related Report
      2017 Annual Research Report

URL: 

Published: 2015-07-02   Modified: 2022-11-04  

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