| Project Area | "LIVING IN SPACE" - Integral Understanding of life-regulation mechanism from "SPACE" |
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| Project/Area Number |
15H05946
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| Research Category |
Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)
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| Allocation Type | Single-year Grants |
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| Review Section |
Complex systems
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| Research Institution | Osaka Ohtani University (2016-2019)
Osaka University (2015) |
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Principal Investigator |
Nasu Masao 大阪大谷大学, 薬学研究科, 教授 (90218040)
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| Co-Investigator(Kenkyū-buntansha) |
杉田 隆 明治薬科大学, 薬学部, 教授 (10312076)
一條 知昭 大阪樟蔭女子大学, 健康栄養学部, 准教授 (20513899)
谷 佳津治 大阪大谷大学, 薬学部, 教授 (50217113)
堀 克敏 名古屋大学, 工学研究科, 教授 (50302956)
槇村 浩一 帝京大学, 公私立大学の部局等, 教授 (00266347)
山崎 丘 帝京大学, 公私立大学の部局等, 講師 (70301174)
中谷 肇 名古屋大学, 工学研究科, 講師 (80456615)
内井 喜美子 大阪大谷大学, 薬学部, 助教 (90469619)
藤山 英保 鳥取大学, 農学部, 特任教授 (90108796)
山口 進康 地方独立行政法人 大阪健康安全基盤研究所, 衛生化学部, 主任研究員 (20252702)
嶋津 徹 国立研究開発法人宇宙航空研究開発機構, 有人宇宙技術部門, 主幹研究開発員 (20639158)
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| Project Period (FY) |
2015-06-29 – 2020-03-31
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| Project Status |
Completed (Fiscal Year 2019)
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| Budget Amount *help |
¥95,030,000 (Direct Cost: ¥73,100,000、Indirect Cost: ¥21,930,000)
Fiscal Year 2019: ¥16,640,000 (Direct Cost: ¥12,800,000、Indirect Cost: ¥3,840,000)
Fiscal Year 2018: ¥16,640,000 (Direct Cost: ¥12,800,000、Indirect Cost: ¥3,840,000)
Fiscal Year 2017: ¥16,640,000 (Direct Cost: ¥12,800,000、Indirect Cost: ¥3,840,000)
Fiscal Year 2016: ¥16,640,000 (Direct Cost: ¥12,800,000、Indirect Cost: ¥3,840,000)
Fiscal Year 2015: ¥28,470,000 (Direct Cost: ¥21,900,000、Indirect Cost: ¥6,570,000)
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| Keywords | 閉鎖環境 / 微生物動態 / 微小重力 / 遺伝子伝播 / バイオフィルム |
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| Outline of Final Research Achievements |
In a confined environment, environmental oligotrophic bacteria remain active on the wall surface, while human-derived bacteria showed high physiological activity in the air. Due to stress found in a confined environment, microbial substitutions among Malassezia species, the predominant skin microbiome, were observed. This suggests that Malassezia could be a stress marker.
We demonstrated that the initial process of the biofilm formation under the microgravity is different from that under the normal gravity; the cell aggregate is formed before initial attachment on the material surface. It was also suggested that the frequency of gene transfer by conjugation was increased under simulated microgravity.
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| Academic Significance and Societal Importance of the Research Achievements |
得られた成果は、宇宙居住空間ならびに地上の高度管理空間における新たな微生物管理基準値の設定に活用でき、ヒトの安全を衛生微生物学的に保障し、また環境中の微生物制御への直接的な貢献が期待される。
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