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Development of fluorescence imaging probes based on new mechanism of fluorescence switching

Planned Research

Project AreaResonance Biology for Innovative Bioimaging
Project/Area Number 15H05951
Research Category

Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)

Allocation TypeSingle-year Grants
Review Section Biological Sciences
Research InstitutionThe University of Tokyo

Principal Investigator

Kamiya Mako  東京大学, 大学院医学系研究科(医学部), 准教授 (90596462)

Project Period (FY) 2015-06-29 – 2020-03-31
Project Status Completed (Fiscal Year 2019)
Budget Amount *help
¥90,480,000 (Direct Cost: ¥69,600,000、Indirect Cost: ¥20,880,000)
Fiscal Year 2019: ¥13,910,000 (Direct Cost: ¥10,700,000、Indirect Cost: ¥3,210,000)
Fiscal Year 2018: ¥13,910,000 (Direct Cost: ¥10,700,000、Indirect Cost: ¥3,210,000)
Fiscal Year 2017: ¥13,910,000 (Direct Cost: ¥10,700,000、Indirect Cost: ¥3,210,000)
Fiscal Year 2016: ¥13,910,000 (Direct Cost: ¥10,700,000、Indirect Cost: ¥3,210,000)
Fiscal Year 2015: ¥34,840,000 (Direct Cost: ¥26,800,000、Indirect Cost: ¥8,040,000)
Keywords蛍光プローブ / 超解像イメージング / 光機能性分子 / 光増感剤 / 蛍光イメージングプローブ / 酸化ストレス
Outline of Final Research Achievements

In this research, we developed a series of fluorescent imaging probes with high versatility based on our molecular design strategy. Specifically, we developed (1) spontaneously blinking fluorophores for multicolor super-resolution imaging in fixed/live cells, (2) a near-infrared fluorescent probe for cancer imaging in deeper tissues, (3) an activatable photosensitizer targeting enzymes overexpressed in cancer for selective ablation of cancer cells. By using these probes, we achieved fluorescence imaging that could not be achieved by conventional methods.

Academic Significance and Societal Importance of the Research Achievements

蛍光プローブを活用したイメージング手法は、「生きている状態」の生物試料の中で起きている様々な現象をリアルタイムに捉えることが可能であり、生物学研究の進展に極めて大きな役割を果たしてきた。本研究では、このようなライブイメージングをさらに発展・普及させるべく、多機能化・多色化した蛍光プローブ群を開発した。これらの蛍光プローブ群は、従来法を凌駕する性能でのライブイメージングを可能とするものであり、今後様々な生命現象の理解、疾患の検出・治療などに用いられることが期待される。

Report

(6 results)
  • 2019 Annual Research Report   Final Research Report ( PDF )
  • 2018 Annual Research Report
  • 2017 Annual Research Report
  • 2016 Annual Research Report
  • 2015 Annual Research Report
  • Research Products

    (150 results)

All 2020 2019 2018 2017 2016 2015 Other

All Int'l Joint Research (8 results) Journal Article (36 results) (of which Int'l Joint Research: 5 results,  Peer Reviewed: 36 results,  Open Access: 12 results,  Acknowledgement Compliant: 6 results) Presentation (90 results) (of which Int'l Joint Research: 15 results,  Invited: 25 results) Patent(Industrial Property Rights) (16 results) (of which Overseas: 8 results)

  • [Int'l Joint Research] Max Planck Institute(ドイツ)

    • Related Report
      2019 Annual Research Report
  • [Int'l Joint Research] Tel Aviv University(イスラエル)

    • Related Report
      2019 Annual Research Report
  • [Int'l Joint Research] Yale University(米国)

    • Related Report
      2017 Annual Research Report
  • [Int'l Joint Research] Academia Sinica(台湾)

    • Related Report
      2017 Annual Research Report
  • [Int'l Joint Research] University of Geneva(スイス)

    • Related Report
      2017 Annual Research Report
  • [Int'l Joint Research] Yale University(米国)

    • Related Report
      2016 Annual Research Report
  • [Int'l Joint Research] Academia Sinica(台湾)

    • Related Report
      2016 Annual Research Report
  • [Int'l Joint Research] University of Geneva(スイス)

    • Related Report
      2016 Annual Research Report
  • [Journal Article] A novel sialidase-activatable fluorescence probe with improved stability for the sensitive detection of sialidase2020

    • Author(s)
      Rivas Charlotte、Kamiya Mako、Urano Yasuteru
    • Journal Title

      Bioorganic & Medicinal Chemistry Letters

      Volume: 30 Issue: 2 Pages: 126860-126860

    • DOI

      10.1016/j.bmcl.2019.126860

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Spontaneously Blinking Fluorophores Based on Nucleophilic Addition/Dissociation of Intracellular Glutathione for Live-Cell Super-resolution Imaging2020

    • Author(s)
      Morozumi Akihiko、Kamiya Mako、Uno Shin-nosuke、Umezawa Keitaro、Kojima Ryosuke、Yoshihara Toshitada、Tobita Seiji、Urano Yasuteru
    • Journal Title

      Journal of the American Chemical Society

      Volume: - Pages: 9625-9633

    • DOI

      10.1021/jacs.0c00451

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Red Fluorescence Probe Targeted to Dipeptidylpeptidase-IV for Highly Sensitive Detection of Esophageal Cancer2019

    • Author(s)
      Ogasawara Akira、Kamiya Mako、Sakamoto Kei、Kuriki Yugo、Fujita Kyohhei、Komatsu Toru、Ueno Tasuku、Hanaoka Kenjiro、Onoyama Haruna、Abe Hiroyuki、Tsuji Yosuke、Fujishiro Mitsuhiro、Koike Kazuhiko、Fukayama Masashi、Seto Yasuyuki、Urano Yasuteru
    • Journal Title

      Bioconjugate Chemistry

      Volume: 30 Issue: 4 Pages: 1055-1060

    • DOI

      10.1021/acs.bioconjchem.9b00198

    • Related Report
      2019 Annual Research Report 2018 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Fluorescence Detection of Prostate Cancer by an Activatable Fluorescence Probe for PSMA Carboxypeptidase Activity2019

    • Author(s)
      Kawatani Minoru、Yamamoto Kyoko、Yamada Daisuke、Kamiya Mako、Miyakawa Jimpei、Miyama Yu、Kojima Ryosuke、Morikawa Teppei、Kume Haruki、Urano Yasuteru
    • Journal Title

      Journal of the American Chemical Society

      Volume: 141 Issue: 26 Pages: 10409-10416

    • DOI

      10.1021/jacs.9b04412

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Highly sensitive fluorescence imaging of cancer with avidin-protease probe conjugate2019

    • Author(s)
      Yamamoto Kyoko、Kamiya Mako、Urano Yasuteru
    • Journal Title

      Bioorganic & Medicinal Chemistry Letters

      Volume: 29 Issue: 20 Pages: 126663-126663

    • DOI

      10.1016/j.bmcl.2019.126663

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed
  • [Journal Article] A novel liver-specific fluorescent anti-cancer drug delivery system using indocyanine green2019

    • Author(s)
      Inagaki Yoshinori、Kokudo Takashi、Kamiya Mako、Uno Shin-nosuke、Sato Masumitsu、Kaneko Junichi、Kokudo Norihiro、Urano Yasuteru、Hasegawa Kiyoshi
    • Journal Title

      Scientific Reports

      Volume: 9 Issue: 1 Pages: 3044-3044

    • DOI

      10.1038/s41598-019-39269-0

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Red-Shifted Fluorogenic Substrate for Detection of lacZ-Positive Cells in Living Tissue with Single-Cell Resolution2018

    • Author(s)
      Ito Hiroki、Kawamata Yu、Kamiya Mako、Tsuda-Sakurai Kayoko、Tanaka Shinji、Ueno Tasuku、Komatsu Toru、Hanaoka Kenjiro、Okabe Shigeo、Miura Masayuki、Urano Yasuteru
    • Journal Title

      Angewandte Chemie International Edition

      Volume: 57 Issue: 48 Pages: 15702-15706

    • DOI

      10.1002/anie.201808670

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed
  • [Journal Article] A Reversible Fluorescent Probe for Real-Time Live-Cell Imaging and Quantification of Endogenous Hydropolysulfides2018

    • Author(s)
      Umezawa Keitaro、Kamiya Mako、Urano Yasuteru
    • Journal Title

      Angewandte Chemie International Edition

      Volume: 57 Issue: 30 Pages: 9346-9350

    • DOI

      10.1002/anie.201804309

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Rapid detection of superficial head and neck squamous cell carcinoma by topically spraying fluorescent probe targeting dipeptidyl peptidase-IV2018

    • Author(s)
      Mizushima Takeshi、Ohnishi Shunsuke、Shimizu Yuichi、Hatanaka Yutaka、Hatanaka Kanako C.、Kuriki Yugo、Kamiya Mako、Homma Akihiro、Yamamoto Keiko、Ono Shouko、Urano Yasuteru、Sakamoto Naoya
    • Journal Title

      Head & Neck

      Volume: 印刷中 Issue: 7 Pages: 1466-1475

    • DOI

      10.1002/hed.25126

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Rapid detection of metastatic lymph nodes of colorectal cancer with a gamma-glutamyl transpeptidase-activatable fluorescence probe2018

    • Author(s)
      Kubo Hidemasa、Hanaoka Kenjiro、Kuriki Yugo、Komatsu Toru、Ueno Tasuku、Kojima Ryosuke、Kamiya Mako、Murayama Yasutoshi、Otsuji Eigo、Urano Yasuteru
    • Journal Title

      Scientific Reports

      Volume: 8 Issue: 1 Pages: 17781-6942

    • DOI

      10.1038/s41598-018-36062-3

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Rapid detection of papillary thyroid carcinoma by fluorescence imaging using a γ-glutamyltranspeptidase-specific probe: a pilot study.2018

    • Author(s)
      Hino R, Inoshita N, Yoshimoto T, Ogawa M, Miura D, Watanabe R, Watanabe K, Kamiya M, Urano Y.
    • Journal Title

      Thyroid Research

      Volume: 11 Issue: 1 Pages: 16-16

    • DOI

      10.1186/s13044-018-0060-y

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Cryogenic Fluorescence Localization Microscopy of Spectrally Selected Individual FRET Pairs in a Water Matrix2018

    • Author(s)
      Tabe Hiroaki、Sukenobe Kei、Kondo Toru、Sakurai Atsunori、Maruo Minako、Shimauchi Akari、Hirano Mitsuharu、Uno Shin-nosuke、Kamiya Mako、Urano Yasuteru、Matsushita Michio、Fujiyoshi Satoru
    • Journal Title

      The Journal of Physical Chemistry B

      Volume: 122 Issue: 27 Pages: 6906-6911

    • DOI

      10.1021/acs.jpcb.8b03977

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Spectral-differential-based unmixing for multispectral photoacoustic imaging2018

    • Author(s)
      Hirasawa Takeshi、Iwatate Ryu J.、Kamiya Mako、Okawa Shinpei、Fujita Masanori、Urano Yasuteru、Ishihara Miya
    • Journal Title

      Applied Optics

      Volume: 57 Issue: 10 Pages: 2383-2383

    • DOI

      10.1364/ao.57.002383

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Establishment of Molecular Design Strategy To Obtain Activatable Fluorescent Probes for Carboxypeptidases2018

    • Author(s)
      Kuriki Yugo、Kamiya Mako、Kubo Hidemasa、Komatsu Toru、Ueno Tasuku、Tachibana Ryo、Hayashi Kento、Hanaoka Kenjiro、Yamashita Suguru、Ishizawa Takeaki、Kokudo Norihiro、Urano Yasuteru
    • Journal Title

      Journal of the American Chemical Society

      Volume: 140 Issue: 5 Pages: 1767-1773

    • DOI

      10.1021/jacs.7b11014

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Silicon Rhodamine-Based Near-Infrared Fluorescent Probe for γ-Glutamyltransferase2018

    • Author(s)
      Iwatate Ryu J.、Kamiya Mako、Umezawa Keitaro、Kashima Hiroki、Nakadate Mamiko、Kojima Ryosuke、Urano Yasuteru
    • Journal Title

      Bioconjugate Chemistry

      Volume: 29 Issue: 2 Pages: 241-244

    • DOI

      10.1021/acs.bioconjchem.7b00776

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed
  • [Journal Article] A green-light-emitting, spontaneously blinking fluorophore based on intramolecular spirocyclization for dual-colour super-resolution imaging2018

    • Author(s)
      Shin-nosuke Uno、Mako Kamiya、Akihiko Morozumia、Yasuteru Urano
    • Journal Title

      Chemical Communications

      Volume: 54 Issue: 1 Pages: 102-105

    • DOI

      10.1039/c7cc07783a

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Factors affecting the uncaging efficiency of 500?nm light-activatable BODIPY caging group2018

    • Author(s)
      Kawatani Minoru、Kamiya Mako、Takahashi Hironori、Urano Yasuteru
    • Journal Title

      Bioorganic & Medicinal Chemistry Letters.

      Volume: 28 Issue: 1 Pages: 1-5

    • DOI

      10.1016/j.bmcl.2017.11.030

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Development of an Activatable Fluorescent Probe for Prostate Cancer Imaging2017

    • Author(s)
      Yogo Takao、Umezawa Keitaro、Kamiya Mako、Hino Rumi、Urano Yasuteru
    • Journal Title

      Bioconjugate Chemistry

      Volume: 28 Issue: 8 Pages: 2069-2076

    • DOI

      10.1021/acs.bioconjchem.7b00233

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed
  • [Journal Article] An Activatable Photosensitizer Targeted to γ-Glutamyltranspeptidase2017

    • Author(s)
      Chiba Mayumi、Ichikawa Yuki、Kamiya Mako、Komatsu Toru、Ueno Tasuku、Hanaoka Kenjiro、Nagano Tetsuo、Lange Norbert、Urano Yasuteru
    • Journal Title

      Angewandte Chemie International Edition

      Volume: 56 Issue: 35 Pages: 10418-10422

    • DOI

      10.1002/anie.201704793

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Long time-lapse nanoscopy with spontaneously blinking membrane probes2017

    • Author(s)
      Takakura Hideo、Zhang Yongdeng、Erdmann Roman S、Thompson Alexander D、Lin Yu、McNellis Brian、Rivera-Molina Felix、Uno Shin-nosuke、Kamiya Mako、Urano Yasuteru、Rothman James E、Bewersdorf Joerg、Schepartz Alanna、Toomre Derek
    • Journal Title

      Nature Biotechnology.

      Volume: 35 Issue: 8 Pages: 773-780

    • DOI

      10.1038/nbt.3876

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Multispectral photoacoustic imaging of tumours in mice injected with an enzyme-activatable photoacoustic probe2017

    • Author(s)
      Hirasawa T, Iwatate JR, Kamiya M, Okawa S, Urano Y, Ishihara M
    • Journal Title

      Journal of Optics

      Volume: 19 Issue: 1 Pages: 14002-14002

    • DOI

      10.1088/2040-8978/19/1/014002

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Rational design of reversible fluorescent probes for live-cell imaging and quantification of fast glutathione dynamics.2017

    • Author(s)
      Umezawa K, Yoshida M, Kamiya M, Yamasoba T, Urano Y
    • Journal Title

      Nature Chemistry

      Volume: 9 Issue: 3 Pages: 279-286

    • DOI

      10.1038/nchem.2648

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Fluorescent imaging of superficial head and neck squamous cell carcinoma using a γ-glutamyltranspeptidase-activated targeting agent: a pilot study.2016

    • Author(s)
      Mizushima T, Ohnishi S, Shimizu Y, Hatanaka Y, Hatanaka KC, Hosono H, Kubota Y, Natsuizaka M, Kamiya M, Ono S, Homma A, Kato M, Sakamoto N, Urano Y
    • Journal Title

      BMC Cancer

      Volume: 16 Issue: 1 Pages: 411-411

    • DOI

      10.1186/s12885-016-2421-z

    • NAID

      120005773989

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Detection of LacZ-Positive Cells in Living Tissue with Single-Cell Resolution.2016

    • Author(s)
      Doura T, Kamiya M, Obata F, Yamaguchi Y, Hiyama TY, Matsuda T, Fukamizu A, Noda M, Miura M, Urano Y
    • Journal Title

      Angew Chem Int Ed

      Volume: 55 Issue: 33 Pages: 9620-9624

    • DOI

      10.1002/anie.201603328

    • NAID

      40021583957

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Rapid diagnosis of lymph node metastasis in breast cancer using a new fluorescent method with γ-glutamyl hydroxymethyl rhodamine green.2016

    • Author(s)
      Shinden Y, et al
    • Journal Title

      Sci Rep.

      Volume: 6 Issue: 1 Pages: 27525-27525

    • DOI

      10.1038/srep27525

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Rapid and sensitive detection of early esophageal squamous cell carcinoma with fluorescence probe targeting dipeptidylpeptidase IV.2016

    • Author(s)
      Onoyama H, Kamiya M, Kuriki Y, Komatsu T, Abe H, Tsuji Y, Yagi K, Yamagata Y, Aikou S, Nishida M, Mori K, Yamashita H, Fujishiro M, Nomura S, Shimizu N, Fukayama M, Koike K, Urano Y, Seto Y
    • Journal Title

      Sci Rep.

      Volume: 6 Issue: 1 Pages: 26399-26399

    • DOI

      10.1038/srep26399

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Rapid Cancer Fluorescence Imaging Using A γ-Glutamyltranspeptidase-Specific Probe For Primary Lung Cancer.2016

    • Author(s)
      Hino H, Kamiya M, Kitano K, Mizuno K, Tanaka S, Nishiyama N, Kataoka K, Urano Y, Nakajima J
    • Journal Title

      Translational Oncology.

      Volume: 9 Issue: 3 Pages: 203-210

    • DOI

      10.1016/j.tranon.2016.03.007

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Novel Hexosaminidase-Targeting Fluorescence Probe for Visualizing Human Colorectal Cancer.2016

    • Author(s)
      Matsuzaki H, Kamiya M, Iwatate RJ, Asanuma D, Watanabe T, Urano Y.
    • Journal Title

      Bioconjug Chem

      Volume: 印刷中 Issue: 4 Pages: 973-981

    • DOI

      10.1021/acs.bioconjchem.6b00037

    • Related Report
      2016 Annual Research Report 2015 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Systemically Injectable Enzyme-Loaded Polyion Complex Vesicles as In Vivo Nanoreactors Functioning in Tumors.2016

    • Author(s)
      Anraku Y, Kishimura A, Kamiya M, Tanaka S, Nomoto T, Toh K, Matsumoto Y, Fukushima S, Sueyoshi D, Kano MR, Urano Y, Nishiyama N, Kataoka K.
    • Journal Title

      Angew Chem Int Ed Engl.

      Volume: 55 Issue: 2 Pages: 560-565

    • DOI

      10.1002/anie.201508339

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Asymmetric Rhodamine-Based Fluorescent Probe for Multicolour In Vivo Imaging.2016

    • Author(s)
      Iwatate RJ, Kamiya M, Urano Y.
    • Journal Title

      Chemistry A European Journal

      Volume: 22 Issue: 5 Pages: 1696-1703

    • DOI

      10.1002/chem.201503426

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] A guide to use photocontrollable fluorescent proteins and synthetic smart fluorophores for nanoscopy2015

    • Author(s)
      Uno SN, Tiwari DK, Kamiya M, Arai Y, Nagai T, Urano Y.
    • Journal Title

      Microscopy

      Volume: 64 Issue: 4 Pages: 263-277

    • DOI

      10.1093/jmicro/dfv037

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Rapid intraoperative visualization of breast lesions with γ-glutamyl hydroxymethyl rhodamine green2015

    • Author(s)
      H.Ueo, Y.Shinden et al.
    • Journal Title

      Scientific Reports

      Volume: 5:12080 Issue: 1 Pages: 1-6

    • DOI

      10.1038/srep12080

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] Analysis of Chemical Equilibrium of Silicon-Substituted Fluorescein and Its Application to Develop a Scaffold for Red Fluorescent Probes2015

    • Author(s)
      K. Hirabayashi, K. Hanaoka, T. Takayanagi, Y. Toki, T. Egawa, M. Kamiya, T. Komatsu, T. Ueno, T. Terai, K. Yoshida, M. Uchiyama, T. Nagano, and Y. Urano
    • Journal Title

      Analytical Chemistry

      Volume: 87(17) Issue: 17 Pages: 9061-9069

    • DOI

      10.1021/acs.analchem.5b02331

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Intraoperative visualization of pancreatic juice leaking from the pancreatic stump in a swine model.2015

    • Author(s)
      Mori K, Ishizawa T, Yamashita S, Kamiya M, Urano Y, Kokudo N.
    • Journal Title

      Gastroenterology

      Volume: 149 Issue: 6 Pages: 1334-1336

    • DOI

      10.1053/j.gastro.2015.07.068

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Development of a Sensitive Bioluminogenic Probe for Imaging Highly Reactive Oxygen Species in Living Rats.2015

    • Author(s)
      Kojima R, Takakura H, Kamiya M, Kobayashi E, Komatsu T, Ueno T, Terai T, Hanaoka K, Nagano T, Urano Y.
    • Journal Title

      Angew Chem Int Ed Engl.

      Volume: 54 Issue: 49 Pages: 14768-14771

    • DOI

      10.1002/anie.201507530

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Quantitating intracellular oxygen tension in vivo by phosphorescence lifetime measurement2015

    • Author(s)
      Hirakawa Y, Yoshihara T, Kamiya M, Mimura I, Fujikura D, Masuda T, Kikuchi R, Takahashi I, Urano Y, Tobita S, Nangaku M.
    • Journal Title

      Sci Rep

      Volume: 5 Issue: 1 Pages: 17838-17838

    • DOI

      10.1038/srep17838

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access
  • [Presentation] Development of activatable fluorescence probes for detecting basic carboxypeptidase activity2020

    • Author(s)
      岩城弘尚、神谷真子、浦野泰照
    • Organizer
      日本化学会 第100春季年会
    • Related Report
      2019 Annual Research Report
  • [Presentation] PSMAのグルタミン酸カルボキシペプチダーゼ活性を標的とした前立腺がん蛍光イメージングプローブの開発2019

    • Author(s)
      神谷 真子、浦野 泰照
    • Organizer
      第92回日本生化学会大会
    • Related Report
      2019 Annual Research Report
    • Invited
  • [Presentation] Rapid cancer imaging by rationally designed fluorescence probes2019

    • Author(s)
      Mako Kamiya, Yasuteru Urano
    • Organizer
      第28回 日本バイオイメージング学会学術集会/第6回 国際バイオイメージングシンポジウム
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Rapid cancer imaging by rationally designed fluorescence probes2019

    • Author(s)
      Mako Kamiya, Yasuteru Urano
    • Organizer
      レゾナンスバイオ国際シンポジウム 2019
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Rapid cancer imaging by rationally designed fluorescence probes2019

    • Author(s)
      Mako Kamiya, Yasuteru Urano
    • Organizer
      EMBL symposium: Seeing is Believing
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Chemical probes for rapid cancer fluorescence imaging2019

    • Author(s)
      Mako Kamiya, Yasuteru Urano
    • Organizer
      第4回UTokyo-NTU Joint Conference
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Rational design of fluorescence probes based on quantum chemical prediction of intramolecular spirocyclization2019

    • Author(s)
      Sascha G. Keller,, Ryo Tachibana, Mako Kamiya, Yasuteru Urano
    • Organizer
      Resonance Bio International Symposium
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Cancer Specific Fluorescence Imaging by Development of Fluorescent Probes for Intact Glycosidase Activities2019

    • Author(s)
      藤田恭平、神谷真子、吉岡孝房、中島淳、上尾裕明、浦野泰照○藤田恭平、神谷真子、吉岡孝房、中島淳、上尾裕明、浦野泰照
    • Organizer
      第14回日本分子イメージング学会
    • Related Report
      2019 Annual Research Report
  • [Presentation] 糖分解酵素活性検出蛍光プローブ群の開発と悪性及び良性腫瘍特異的蛍光イメージングへの応用2019

    • Author(s)
      藤田恭平、神谷真子、吉岡孝房、小笠原輝、上尾裕明、浦野泰照
    • Organizer
      第13回バイオ関連化学シンポジウム
    • Related Report
      2019 Annual Research Report
  • [Presentation] PSMA活性検出プローブによる前立腺がん蛍光イメージング2019

    • Author(s)
      山本恭子、河谷稔、山田大介、森川鉄平、神谷真子、久米春喜、浦野泰照
    • Organizer
      日本薬学会第139年会
    • Related Report
      2018 Annual Research Report
  • [Presentation] Development of spontaneously blinking fluorophores based on nucleophilic addition of intracellular glutathione for super-resolution imaging2019

    • Author(s)
      A. Morozumi, M. Kamiya, S. Uno, K. Umezawa, T. Yoshihara, S. Tobita, Y. Urano
    • Organizer
      日本化学会 第99春季年会
    • Related Report
      2018 Annual Research Report
  • [Presentation] 自発的な光明滅機能を有する超解像イメージングプローブの開発2018

    • Author(s)
      神谷真子・浦野泰照
    • Organizer
      日本顕微鏡学会第74回学術講演会
    • Related Report
      2018 Annual Research Report
    • Invited
  • [Presentation] 蛍光プローブの論理的設計によるがん蛍光イメージング2018

    • Author(s)
      神谷真子・浦野泰照
    • Organizer
      第13回 分子イメージング学会
    • Related Report
      2018 Annual Research Report
    • Invited
  • [Presentation] オリジナル蛍光プロープの開発によるがん蛍光イメージング2018

    • Author(s)
      神谷真子・浦野泰照
    • Organizer
      第130委員会 第313回研究会
    • Related Report
      2018 Annual Research Report
    • Invited
  • [Presentation] オリジナル蛍光プロープの開発によるがん蛍光イメージング2018

    • Author(s)
      神谷真子
    • Organizer
      CBI2018
    • Related Report
      2018 Annual Research Report
    • Invited
  • [Presentation] Rational design of reversible fluorescent probes for live-cell imaging and quantification of fast glutathione dynamics2018

    • Author(s)
      Mako Kamiya
    • Organizer
      ProbeFesta2018
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Rapid cancer imaging by rationally designed fluorescence probes2018

    • Author(s)
      Mako Kamiya
    • Organizer
      ABiS-GBI-OIST-ResonanceBio Joint Symposium ‘Frontiers in Bioimaging’
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] 自発的な光明滅機能を有する超解像イメージングプローブの開発2018

    • Author(s)
      神谷真子
    • Organizer
      第41回日本分子生物学会
    • Related Report
      2018 Annual Research Report
    • Invited
  • [Presentation] Glycosynthaseによる糖鎖分解酵素活性検出蛍光プローブライブラリーの構築とがん蛍光イメージングへの応用2018

    • Author(s)
      藤田恭平、神谷真子、内山拓、五十嵐圭日子、浦野泰照
    • Organizer
      第13回 日本分子イメージング学会学術集会
    • Related Report
      2018 Annual Research Report
  • [Presentation] 細胞内滞留性ペプチダーゼ蛍光プローブの開発2018

    • Author(s)
      小原塁・神谷真子・浦野泰照
    • Organizer
      第13回 日本ケミカルバイオロジー学会
    • Related Report
      2018 Annual Research Report
  • [Presentation] A novel prodrug strategy for selective tumor ablation based on cancer-specific enzyme activities2018

    • Author(s)
      Kento Hayashi, Mako Kamiya, Hidemasa Kubo, Yasuteru Urano
    • Organizer
      Frontiers2018
    • Related Report
      2018 Annual Research Report
  • [Presentation] 蛍光プローブライブラリーの創製による新規がんイメージングの実現2018

    • Author(s)
      栗木優五、神谷真子、小松徹、斎藤豊、浦野泰照
    • Organizer
      第12回バイオ関連化学シンポジウム
    • Related Report
      2018 Annual Research Report
  • [Presentation] Hydroxymethyl Rhodamine類の分子内反応を応用した非経験的蛍光プローブ設計法の開発2018

    • Author(s)
      橘椋, 神谷真子, 鈴木聡, 諸熊奎治, 浦野泰照
    • Organizer
      第13回 日本ケミカルバイオロジー学会
    • Related Report
      2018 Annual Research Report
  • [Presentation] In vivoがん治療効果イメージングを志向した可逆的glutathione蛍光プローブの開発2018

    • Author(s)
      西堀純平、神谷真子、梅澤啓太郎、浦野泰照
    • Organizer
      日本薬学会第138年会
    • Related Report
      2017 Annual Research Report
  • [Presentation] Hydroxymethy rhodamine類の光特性を応用した細胞内pH測定法の開発2018

    • Author(s)
      有馬陵汰、神谷真子、両角明彦、浦野泰照
    • Organizer
      第138回 日本薬学会年会
    • Related Report
      2017 Annual Research Report
  • [Presentation] 新規蛍光寿命イメージングプローブによる細胞内酸性小胞のpH測定2018

    • Author(s)
      國府田絹子、神谷真子、浦野泰照
    • Organizer
      日本薬学会 第138年会
    • Related Report
      2017 Annual Research Report
  • [Presentation] Glycosynthaseによる糖鎖分解酵素活性検出蛍光プローブライブラリーの構築とがん蛍光イメージングへの応用2018

    • Author(s)
      藤田恭平、神谷真子、内山拓、五十嵐圭日子、浦野泰照
    • Organizer
      日本薬学会第138年会
    • Related Report
      2017 Annual Research Report
  • [Presentation] 疾患イメージングを指向した新規Activatable型カルボキシペプチダーゼ活性検出プローブの開発2018

    • Author(s)
      栗木優五、神谷真子、小松徹、上野匡、山下俊、國土典宏、浦野泰照
    • Organizer
      日本薬学会第138年会
    • Related Report
      2017 Annual Research Report
  • [Presentation] 組織中lacZ発現細胞のライブ検出を可能とする蛍光プローブの開発2018

    • Author(s)
      神谷真子、堂浦智裕、浦野泰照
    • Organizer
      有機合成化学協会関西支部主催2月セミナー
    • Related Report
      2017 Annual Research Report
    • Invited
  • [Presentation] Detection of LacZ-Positive Cells in Living Tissue with Single-Cell Resolution2018

    • Author(s)
      Mako KAMIYA, Yasuteru URANO
    • Organizer
      Pittcon 2018
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] 分子内スピロ環化平衡に基づく革新的バイオイメージングツールの創製2018

    • Author(s)
      神谷真子、浦野泰照
    • Organizer
      日本化学会 第98春季年会 (2018)
    • Related Report
      2017 Annual Research Report
    • Invited
  • [Presentation] 多機能蛍光プローブ群による組織内 1 細胞機能解析2018

    • Author(s)
      神谷真子
    • Organizer
      日本化学会 第98春季年会 (2018)
    • Related Report
      2017 Annual Research Report
  • [Presentation] ライブ蛍光寿命イメージングによる酸性pH測定を可能とする新規蛍光プローブの開発2017

    • Author(s)
      ○國府田絹子、神谷真子、浦野泰照
    • Organizer
      日本薬学会 第137年会
    • Place of Presentation
      仙台国際センター(宮城県仙台市)
    • Year and Date
      2017-03-27
    • Related Report
      2016 Annual Research Report
  • [Presentation] 細胞内グルタチオンの求核付加・解離平衡に基づく超解像蛍光イメージングプローブの開発2017

    • Author(s)
      ◯両角明彦、神谷真子、宇野真之介、梅澤啓太郎、吉原利忠、飛田成史、浦野泰照
    • Organizer
      日本薬学会第137年会
    • Place of Presentation
      東北大学 川内キャンパス(宮城県仙台市)
    • Year and Date
      2017-03-27
    • Related Report
      2016 Annual Research Report
  • [Presentation] Hydroxymethyl Rhodamine類の分子内反応解析に基づく蛍光プローブ設計法の開発2017

    • Author(s)
      ○橘椋、神谷真子、鈴木聡、諸熊奎治、浦野泰照
    • Organizer
      日本薬学会 第137年会
    • Place of Presentation
      東北大学川内北キャンパス (宮城県仙台市)
    • Year and Date
      2017-03-27
    • Related Report
      2016 Annual Research Report
  • [Presentation] 組織中lacZ発現細胞のライブ検出を可能とする蛍光プローブの開発2017

    • Author(s)
      ○神谷 真子、浦野泰照
    • Organizer
      日本薬学会 第137年会
    • Place of Presentation
      仙台国際センター(宮城県仙台市)
    • Year and Date
      2017-03-26
    • Related Report
      2016 Annual Research Report
    • Invited
  • [Presentation] SNAPtag activatable超解像イメージングプローブの開発2017

    • Author(s)
      ○宮崎善行、神谷真子、浦野泰照
    • Organizer
      日本薬学会 第137年会
    • Place of Presentation
      仙台国際センター(宮城県仙台市)
    • Year and Date
      2017-03-26
    • Related Report
      2016 Annual Research Report
  • [Presentation] アビジン-蛍光プローブ複合体による高感度がんイメージング2017

    • Author(s)
      ○山本恭子・神谷真子・浦野泰照
    • Organizer
      日本薬学会第137年会
    • Place of Presentation
      東北大学 川内北キャンパス(宮城県仙台市)
    • Year and Date
      2017-03-25
    • Related Report
      2016 Annual Research Report
  • [Presentation] 赤色蛍光プローブライブラリーの創製による新規がんイメージングの実現2017

    • Author(s)
      ○小笠原輝、神谷真子、浦野泰照
    • Organizer
      第137回日本薬学会
    • Place of Presentation
      仙台国際センター(宮城県仙台市)
    • Year and Date
      2017-03-25
    • Related Report
      2016 Annual Research Report
  • [Presentation] 新規Activatable型Carboxypeptidase活性検出蛍光プローブの開発と応用2017

    • Author(s)
      ○栗木優五、神谷真子、小松徹、上野匡、山下俊、國土典宏、浦野泰照
    • Organizer
      日本薬学会第137年会
    • Place of Presentation
      東北大学川内キャンパス(宮城県仙台市)
    • Year and Date
      2017-03-25
    • Related Report
      2016 Annual Research Report
  • [Presentation] Development of Multicolour Activatable Protease Probes for Fluorescence and Photoacoustic Cancer Imaging2017

    • Author(s)
      ○岩立竜・神谷真子・平沢壮・石原美弥・浦野泰照
    • Organizer
      日本化学会 第97春季年会
    • Place of Presentation
      慶應義塾大学 日吉キャンパス(神奈川県横浜市港北区)
    • Year and Date
      2017-03-17
    • Related Report
      2016 Annual Research Report
  • [Presentation] Development of a highly sensitive fluorescence probe for the detection of sialidase in cancer tissue2017

    • Author(s)
      ○ Charlotte Rivas, Mako Kamiya, Yasuteru Urano
    • Organizer
      日本化学会 第97春季年会
    • Place of Presentation
      慶應義塾大学 日吉キャンパス(神奈川県横浜市)
    • Year and Date
      2017-03-17
    • Related Report
      2016 Annual Research Report
  • [Presentation] 組織中lacZ発現細胞のライブ検出を可能とする蛍光プローブの開発2017

    • Author(s)
      ○神谷 真子、浦野泰照
    • Organizer
      日本化学会第97春季年会
    • Place of Presentation
      慶応義塾大学 日吉キャンパス (神奈川県横浜市)
    • Year and Date
      2017-03-16
    • Related Report
      2016 Annual Research Report
    • Invited
  • [Presentation] Rational Control of Fluorescence by Intramolecular Spirocyclization of Hydroxymethyl Rhodamine Derivatives2017

    • Author(s)
      ○橘椋、神谷真子、鈴木聡、諸熊奎治、浦野泰照
    • Organizer
      日本化学会第97春季年会
    • Place of Presentation
      慶応義塾大学 日吉キャンパス(神奈川県横浜市)
    • Year and Date
      2017-03-16
    • Related Report
      2016 Annual Research Report
  • [Presentation] Detection of LacZ-Positive Cells in Living Tissue with Single-Cell Resolution2017

    • Author(s)
      ○Mako Kamiya, Yasuteru Urano
    • Organizer
      1st ABiS Symposium
    • Place of Presentation
      自然科学研究機構 岡崎コンファレンスセンター(愛知県岡崎市)
    • Year and Date
      2017-02-19
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Development of spontaneously blinking fluorophores based on nucleophilic addition of intracellular glutathione for super-resolution imaging2017

    • Author(s)
      ◯A. Morozumi, M. Kamiya, S. Uno, K. Umezawa, T. Yoshihara, S. Tobita, Y. Urano
    • Organizer
      1st ABiS Symposium
    • Place of Presentation
      自然科学研究機構 岡崎コンファレンスセンター
    • Year and Date
      2017-02-19
    • Related Report
      2016 Annual Research Report
  • [Presentation] BODIPY-based visible-light activatable caging groups with improved single-photon uncaging efficiency2017

    • Author(s)
      ○Minoru Kawatani, Mako Kamiya, Yasuteru Urano
    • Organizer
      SPIE BiOS 2017
    • Place of Presentation
      Moscone Center West(San Francisco, US)
    • Year and Date
      2017-01-29
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Development of spontaneously blinking fluorophores based on nucleophilic addition of intracellular glutathione for super-resolution imaging2017

    • Author(s)
      A. Morozumi, M. Kamiya, S. Uno, K. Umezawa, T. Yoshihara, S. Tobita, Y. Urano
    • Organizer
      第55回日本生物物理学会年会
    • Related Report
      2017 Annual Research Report
  • [Presentation] Development of spontaneously blinking fluorophores based on nucleophilic addition of intracellular glutathione for super-resolution imaging2017

    • Author(s)
      A. Morozumi, M. Kamiya, S. Uno, K. Umezawa, T. Yoshihara, S. Tobita, Y. Urano
    • Organizer
      Taiwan-Japan Joint Meeting on Bioimaging for Young Researchers
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] SNAP-tag activatableな超解像イメージプローブの開発2017

    • Author(s)
      宮崎善行・神谷真子・浦野泰照
    • Organizer
      生体機能関連化学若手の会第29回サマースクール
    • Related Report
      2017 Annual Research Report
  • [Presentation] 溶媒としての水分子を考慮した量子化学計算に基づく新規蛍光プローブの開発2017

    • Author(s)
      橘椋、神谷真子、鈴木聡、諸熊奎治、浦野泰照
    • Organizer
      第30回バイオメディカル分析科学シンポジウム
    • Related Report
      2017 Annual Research Report
  • [Presentation] 脳腫瘍を標識する噴霧式新規蛍光プローブの開発2017

    • Author(s)
      北川陽介・田中將太・小笠原輝・栗木優五・山本恭子・神谷真子・武笠晃丈・浦野泰照・斉藤延人
    • Organizer
      第35回日本脳腫瘍学会
    • Related Report
      2017 Annual Research Report
  • [Presentation] 生細胞内の活性イオウ種の可逆的可視化を目指した蛍光プローブの開発2017

    • Author(s)
      梅澤啓太郎、神谷真子、浦野泰照
    • Organizer
      第12回 日本分子イメージング学会学術集会
    • Related Report
      2017 Annual Research Report
  • [Presentation] 活性イオウ種の可逆的可視化を指向した蛍光プローブの開発と生細胞イメージングへの展開2017

    • Author(s)
      梅澤啓太郎、吉田昌史、神谷真子、浦野泰照
    • Organizer
      第11回バイオ関連化学シンポジウム
    • Related Report
      2017 Annual Research Report
  • [Presentation] 赤色蛍光プローブライブラリーの創製による新規がんイメージングの実現2017

    • Author(s)
      小笠原輝・神谷真子・坂本啓・愛甲丞・瀬戸泰之・浦野泰照
    • Organizer
      第12回日本分子イメージング学会学術集会
    • Related Report
      2017 Annual Research Report
  • [Presentation] 赤色蛍光プローブライブラリーの創製による新規がんイメージングの実現2017

    • Author(s)
      小笠原輝・神谷真子・坂本啓・愛甲丞・瀬戸泰之・浦野泰照
    • Organizer
      日本ケミカルバイオロジー学会第12回年会
    • Related Report
      2017 Annual Research Report
  • [Presentation] A spontaneously blinking fluorophore based on intramolecularspirocyclization for live-cell super-resolution imaging2017

    • Author(s)
      Shin-nosuke Uno, Mako Kamiya, Toshitada Yoshihara, Ko Sugawara, Kohki Okabe, Takashi Funatsu, Yasushi Okada, Seiji Tobita, Yasuteru Urano
    • Organizer
      International Symposium on Imaging Frontier 2017 (ISIF 2017)
    • Related Report
      2017 Annual Research Report
  • [Presentation] 新規 Activatable 型 カルボキシペプチダーゼ活性検出蛍光プローブの開発と応用2017

    • Author(s)
      栗木優五、神谷真子、小松徹、上野匡、山下俊、國土典宏、浦野泰照
    • Organizer
      第11回バイオ関連化学シンポジウム
    • Related Report
      2017 Annual Research Report
  • [Presentation] 化学プローブを精密にデザインして癌を光らせる!2017

    • Author(s)
      神谷真子
    • Organizer
      第5回慶應有機化学若手シンポジウム
    • Related Report
      2017 Annual Research Report
    • Invited
  • [Presentation] Detection of lacZ-positive cells in living tissue with single-cell resolution2017

    • Author(s)
      Mako KAMIYA, Yasuteru URANO
    • Organizer
      EMBL Symposium: Seeing is Believing - Imaging the Processes of Life
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Detection of LacZ-Positive Cells in Living Tissue with Single-Cell Resolution2017

    • Author(s)
      Mako KAMIYA, Yasuteru URANO
    • Organizer
      Taiwan-Japan Joint Meeting on Bioimaging for Young Researchers
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Spontaneously blinking fluorophores for super-resolution imaging2017

    • Author(s)
      Mako KAMIYA, Akihico MOROZUMI, Shin-nosuke UNO, Yasuteru URANO
    • Organizer
      the 3rd East-Asia Microscopy Conference
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Rapid cancer imaging by rationally designed fluorescence probes2016

    • Author(s)
      ○Mako Kamiya, Yasuteru Urano
    • Organizer
      第54回日本生物物理学会年会
    • Place of Presentation
      つくば国際会議場(茨城県つくば市)
    • Year and Date
      2016-11-26
    • Related Report
      2016 Annual Research Report
    • Invited
  • [Presentation] Development of spontaneously blinking fluorophores based on nucleophilic addition of intracellular glutathione for super-resolution imaging2016

    • Author(s)
      ◯A. Morozumi, M. Kamiya, S. Uno, K. Umezawa, T. Yoshihara, S. Tobita, Y. Urano
    • Organizer
      第54回日本生物物理学会年会
    • Place of Presentation
      つくば国際会議場(茨城県つくば市)
    • Year and Date
      2016-11-25
    • Related Report
      2016 Annual Research Report
  • [Presentation] A Novel cancer imaging technology by constructing a fluorescent probe library2016

    • Author(s)
      ○Yugo Kuriki, Mako Kamiya, Haruna Onoyama, Toru Komatsu, Yasuyuki Seto, Yasuteru Urano
    • Organizer
      International Chemical Biology Society 2016
    • Place of Presentation
      Memorial Union (Wisconsin, USA)
    • Year and Date
      2016-10-26
    • Related Report
      2016 Annual Research Report
  • [Presentation] 生細胞内の活性イオウ種の可逆的可視化に資する蛍光プローブの開発2016

    • Author(s)
      ○梅澤啓太郎、吉田昌史、神谷真子、浦野泰照
    • Organizer
      第89回日本生化学会
    • Place of Presentation
      仙台国際センター(宮城県仙台市)
    • Year and Date
      2016-09-27
    • Related Report
      2016 Annual Research Report
    • Invited
  • [Presentation] 蛍光プローブライブラリーの創製による新規がんイメージングの実現2016

    • Author(s)
      ○栗木優五、神谷真子、小野山温那、小松徹、瀬戸泰之、浦野泰照
    • Organizer
      第89回日本生化学会大会6
    • Place of Presentation
      仙台国際センター(宮城県仙台市)
    • Year and Date
      2016-09-26
    • Related Report
      2016 Annual Research Report
  • [Presentation] 細胞内グルタチオンの求核付加・解離平衡に基づく超解像蛍光イメージングプローブの開発2016

    • Author(s)
      ◯両角明彦、神谷真子、宇野真之介、梅澤啓太郎、吉原利忠、飛田成史、浦野泰照
    • Organizer
      第25回日本バイオイメージング学会学術集会
    • Place of Presentation
      名古屋市立大学薬学部 宮田専治記念ホール (愛知県名古屋市)
    • Year and Date
      2016-09-25
    • Related Report
      2016 Annual Research Report
  • [Presentation] Rapid cancer imaging by rationally designed fluorescence probes2016

    • Author(s)
      ○Mako Kamiya, Yasuteru Urano
    • Organizer
      JSAP-OSA Joint Symposia
    • Place of Presentation
      朱鷺メッセ(新潟県新潟市)
    • Year and Date
      2016-09-15
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] 癌細胞の精密可視化を目指した細胞内滞留性ペプチダーゼ蛍光プローブの開発2016

    • Author(s)
      ○小原塁、神谷真子、浦野泰照
    • Organizer
      日本分析化学会 第65年会
    • Place of Presentation
      北海道大学工学部(北海道札幌市)
    • Year and Date
      2016-09-14
    • Related Report
      2016 Annual Research Report
  • [Presentation] 生細胞内のハイドロパースルフィドの可逆的可視化を可能とする蛍光プローブの開発2016

    • Author(s)
      ○梅澤啓太郎、神谷真子、浦野泰照
    • Organizer
      第69回酸化ストレス学会
    • Place of Presentation
      仙台国際センター (宮城県仙台市)
    • Year and Date
      2016-08-30
    • Related Report
      2016 Annual Research Report
  • [Presentation] BODIPYを基本骨格としたアンケージ量子収率の高い可視光分解性保護基の開発2016

    • Author(s)
      ○河谷稔、神谷真子、浦野泰照
    • Organizer
      日本ケミカルバイオロジー学会 第11回年会
    • Place of Presentation
      京都テルサ テルサホール(京都府京都市)
    • Year and Date
      2016-06-17
    • Related Report
      2016 Annual Research Report
  • [Presentation] 細胞内グルタチオンの求核付加・解離平衡に基づく超解像蛍光イメージングプローブの開発2016

    • Author(s)
      ◯両角明彦、神谷真子、宇野真之介、梅澤啓太郎、吉原利忠、飛田成史、浦野泰照
    • Organizer
      日本ケミカルバイオロジー学会第11回年会
    • Place of Presentation
      京都テルサ テルサホール
    • Year and Date
      2016-06-15
    • Related Report
      2016 Annual Research Report
  • [Presentation] アビジン-蛍光プローブ複合体を用いた高感度がんイメージング2016

    • Author(s)
      ○山本恭子・神谷真子・浦野泰照
    • Organizer
      第11回日本分子イメージング学会学術集会
    • Place of Presentation
      神戸国際会議場(兵庫県神戸市)
    • Year and Date
      2016-05-28
    • Related Report
      2016 Annual Research Report
  • [Presentation] An activatable photosensitizer targeted to γ-glutamyltranspeptidase for tumor selective photodynamic therapy2016

    • Author(s)
      ○Mako KAMIYA, Mayumi CHIBA, Yuki ICHIKAWA, Norbert LANGE, Yasuteru URANO
    • Organizer
      第7回アジア太平洋トピックカンファレンス
    • Place of Presentation
      京王プラザホテル(東京都新宿区)
    • Year and Date
      2016-04-20
    • Related Report
      2016 Annual Research Report
  • [Presentation] 化学蛍光プローブの精密設計による革新的バイオイメージングツールの創製2016

    • Author(s)
      神谷真子
    • Organizer
      日本薬学会 第136年会(薬学会奨励賞受賞講演)
    • Place of Presentation
      パシフィコ横浜(神奈川県横浜市)
    • Year and Date
      2016-03-29
    • Related Report
      2015 Annual Research Report
  • [Presentation] 生細胞における酸性小胞のpH測定が可能な蛍光寿命イメージングプローブの開発2016

    • Author(s)
      國府田絹子、神谷真子、浦野泰照
    • Organizer
      日本薬学会 第136年会
    • Place of Presentation
      パシフィコ横浜(神奈川県横浜市)
    • Year and Date
      2016-03-28
    • Related Report
      2015 Annual Research Report
  • [Presentation] β-galactosidaseにより光増感能が回復する新規光増感剤の開発2016

    • Author(s)
      千葉真由美・神谷真子・浦野泰照
    • Organizer
      日本薬学会 第136回年会
    • Place of Presentation
      パシフィコ横浜(神奈川県横浜市)
    • Year and Date
      2016-03-28
    • Related Report
      2015 Annual Research Report
  • [Presentation] 癌細胞の精密可視化を目指した細胞内滞留性ペプチダーゼ蛍光プローブの 開発2016

    • Author(s)
      小原塁、神谷真子、浦野泰照
    • Organizer
      日本薬学会 第136年回
    • Place of Presentation
      パシフィコ横浜 (神奈川県横浜市)
    • Year and Date
      2016-03-28
    • Related Report
      2015 Annual Research Report
  • [Presentation] 化学プローブを精密にデザインして癌を光らせる!2016

    • Author(s)
      神谷真子、浦野泰照
    • Organizer
      日本薬学会 第136年会(一般シンポジウム)
    • Place of Presentation
      パシフィコ横浜(神奈川県横浜市)
    • Year and Date
      2016-03-27
    • Related Report
      2015 Annual Research Report
  • [Presentation] BODIPY-based photoremovable protective groups with improved photoreaction efficiency2016

    • Author(s)
      KAWATANI, Minoru; KAMIYA, Mako; URANO, Yasuteru
    • Organizer
      日本化学会第96春季年会
    • Place of Presentation
      同志社大学 京田辺キャンパス(京都府京田辺市)
    • Year and Date
      2016-03-26
    • Related Report
      2015 Annual Research Report
  • [Presentation] 細胞内グルタチオンとの求核付加・解離平衡反応を利用した超解像蛍光イメージングプローブの開発2016

    • Author(s)
      両角明彦、神谷真子、宇野真之介、梅澤啓太郎、吉原利忠、飛田成史、浦野泰照
    • Organizer
      日本化学会 第96春季年会
    • Place of Presentation
      同志社大学 京田辺キャンパス(京都府京田辺市)
    • Year and Date
      2016-03-26
    • Related Report
      2015 Annual Research Report
  • [Presentation] Development of Avidin-Fluorescent Probe Conjugate for Highly Sensitive and Specific Cancer Imaging2016

    • Author(s)
      YAMAMOTO, Kyoko; KAMIYA, Mako; URANO, Yasuteru
    • Organizer
      日本化学会第96春季年会
    • Place of Presentation
      同志社大学 京田辺キャンパス(京都府京田辺市)
    • Year and Date
      2016-03-26
    • Related Report
      2015 Annual Research Report
  • [Presentation] 新しいスイッチング機構に基づく高精度蛍光イメージングプローブの開発2016

    • Author(s)
      神谷真子、浦野泰照
    • Organizer
      レゾナンスバイオ公開シンポジウム「Swinging on the Chromophore」
    • Place of Presentation
      KKR熱海 (静岡県熱海市)
    • Year and Date
      2016-03-16
    • Related Report
      2015 Annual Research Report
  • [Presentation] Activatable蛍光プローブの開発による癌蛍光イメージング2016

    • Author(s)
      神谷真子、浦野泰照
    • Organizer
      「がん研究分野の特性等を踏まえた支援活動」 公開シンポジウム
    • Place of Presentation
      一橋講堂(学術総合センター2F)(東京都千代田区)
    • Year and Date
      2016-02-09
    • Related Report
      2015 Annual Research Report
  • [Presentation] Fluorescence-guided detection of tumors by aminopeptidase-activatable fluorescent probes2015

    • Author(s)
      Mako Kamiya, Yasuteru Urano
    • Organizer
      BMB2015(第38回日本分子生物学会年会、第88回日本生化学会大会 合同大会)
    • Place of Presentation
      神戸ポートピアホテル(兵庫県神戸市)
    • Year and Date
      2015-12-03
    • Related Report
      2015 Annual Research Report
  • [Presentation] Fluorescence-guided detection of tumors by glycosidase-activatable fluorescent probes2015

    • Author(s)
      Mako Kamiya, Daisuke Asanuma, Yasuteru Urano
    • Organizer
      第74回日本癌学会学術総会
    • Place of Presentation
      名古屋国際会議場(愛知県名古屋市)
    • Year and Date
      2015-10-08
    • Related Report
      2015 Annual Research Report
    • Invited
  • [Presentation] Rapid human esophageal cancer detection by applying aminopeptidase-activatable fluorescence probes2015

    • Author(s)
      小野山温那、神谷真子、八木浩一、愛甲丞、西田正人、山下裕玄、野村幸世、瀬戸泰之、浦野泰照
    • Organizer
      第74回日本癌学会学術総会
    • Place of Presentation
      名古屋国際会議場(愛知県名古屋市)
    • Year and Date
      2015-10-08
    • Related Report
      2015 Annual Research Report
  • [Presentation] 可逆的応答を示すグルタチオン感受性蛍光プローブの開発と生細胞イメージングへの展開2015

    • Author(s)
      梅澤啓太郎、吉田昌史、神谷真子、浦野泰照
    • Organizer
      第9回バイオ関連化学シンポジウム
    • Place of Presentation
      熊本大学工学部(熊本県熊本市)
    • Year and Date
      2015-09-10
    • Related Report
      2015 Annual Research Report
  • [Presentation] 異なるプロテアーゼ活性を持つがんのin vivo同時多色イメージングを可能とする蛍光プローブ群の開発2015

    • Author(s)
      岩立竜・神谷真子・浦野泰照
    • Organizer
      第9回バイオ関連化学シンポジウム
    • Place of Presentation
      熊本大学(熊本県熊本市)
    • Year and Date
      2015-09-10
    • Related Report
      2015 Annual Research Report
  • [Patent(Industrial Property Rights)] 癌検出蛍光プローブ2020

    • Inventor(s)
      浦野泰照、神谷真子、藤田恭平
    • Industrial Property Rights Holder
      国立大学法人東 京大学
    • Industrial Property Rights Type
      特許
    • Filing Date
      2020
    • Related Report
      2019 Annual Research Report
    • Overseas
  • [Patent(Industrial Property Rights)] カルボキシペプチダーゼ活性検出用蛍光プローブ2019

    • Inventor(s)
      浦野泰照、神谷真子、栗木優五
    • Industrial Property Rights Holder
      国立大学法人東 京大学
    • Industrial Property Rights Type
      特許
    • Filing Date
      2019
    • Related Report
      2019 Annual Research Report
    • Overseas
  • [Patent(Industrial Property Rights)] カルボキシペプチダーゼ活性検出用蛍光プローブ2019

    • Inventor(s)
      浦野泰照,神谷真子,河谷稔,岩城弘尚,山本恭子、他2名
    • Industrial Property Rights Holder
      国立大学法人東京大学
    • Industrial Property Rights Type
      特許
    • Filing Date
      2019
    • Related Report
      2018 Annual Research Report
    • Overseas
  • [Patent(Industrial Property Rights)] がん特異的酵素活性を利用したプロドラッグ型抗がん剤2019

    • Inventor(s)
      浦野 泰照,神谷 真子,林 健人
    • Industrial Property Rights Holder
      国立大学法人東京大学
    • Industrial Property Rights Type
      特許
    • Filing Date
      2019
    • Related Report
      2018 Annual Research Report
    • Overseas
  • [Patent(Industrial Property Rights)] シアリダーゼ活性検出蛍光プローブ2019

    • Inventor(s)
      浦野 泰照,神谷 真子,シャーロット リバス
    • Industrial Property Rights Holder
      国立大学法人東京大学
    • Industrial Property Rights Type
      特許
    • Industrial Property Number
      2019-039095
    • Filing Date
      2019
    • Related Report
      2018 Annual Research Report
  • [Patent(Industrial Property Rights)] 癌検出蛍光プローブ2019

    • Inventor(s)
      浦野 泰照,神谷 真子,藤田 恭平
    • Industrial Property Rights Holder
      国立大学法人東京大学
    • Industrial Property Rights Type
      特許
    • Industrial Property Number
      2019-036670
    • Filing Date
      2019
    • Related Report
      2018 Annual Research Report
  • [Patent(Industrial Property Rights)] 新規蛍光プローブ2018

    • Inventor(s)
      浦野 泰照,神谷 真子,小笠原 輝
    • Industrial Property Rights Holder
      国立大学法人東京大学
    • Industrial Property Rights Type
      特許
    • Industrial Property Number
      2018-210101
    • Filing Date
      2018
    • Related Report
      2018 Annual Research Report
  • [Patent(Industrial Property Rights)] カルボキシペプチダーゼ活性検出用蛍光プローブ2018

    • Inventor(s)
      浦野 泰照,神谷 真子,栗木 優五
    • Industrial Property Rights Holder
      国立大学法人東京大学
    • Industrial Property Rights Type
      特許
    • Industrial Property Number
      2018-225735
    • Filing Date
      2018
    • Related Report
      2018 Annual Research Report
  • [Patent(Industrial Property Rights)] 酵素特異的な細胞内滞留性赤色蛍光プローブ2017

    • Inventor(s)
      浦野泰照、神谷真子、伊藤央樹、川又優
    • Industrial Property Rights Holder
      国立大学法人東京大学
    • Industrial Property Rights Type
      特許
    • Filing Date
      2017
    • Related Report
      2017 Annual Research Report
    • Overseas
  • [Patent(Industrial Property Rights)] ペプチダーゼ活性検出用赤色蛍光プローブ2017

    • Inventor(s)
      浦野泰照、神谷真子、橘椋
    • Industrial Property Rights Holder
      国立大学法人東京大学
    • Industrial Property Rights Type
      特許
    • Filing Date
      2017
    • Related Report
      2017 Annual Research Report
    • Overseas
  • [Patent(Industrial Property Rights)] ペプチダーゼ活性検出用近赤外蛍光プローブ2017

    • Inventor(s)
      浦野泰照、神谷真子、岩立竜
    • Industrial Property Rights Holder
      国立大学法人東京大学
    • Industrial Property Rights Type
      特許
    • Filing Date
      2017
    • Related Report
      2017 Annual Research Report
    • Overseas
  • [Patent(Industrial Property Rights)] カルボキシペプチダーゼ活性検出用蛍光プローブ2017

    • Inventor(s)
      浦野泰照、神谷真子、河谷稔,岩城 弘尚
    • Industrial Property Rights Holder
      国立大学法人東京大学
    • Industrial Property Rights Type
      特許
    • Industrial Property Number
      2018-037791
    • Filing Date
      2017
    • Related Report
      2017 Annual Research Report
  • [Patent(Industrial Property Rights)] がん特異的酵素活性を利用したプロドラッグ型抗がん剤2017

    • Inventor(s)
      浦野泰照、神谷真子、林健人
    • Industrial Property Rights Holder
      国立大学法人東京大学
    • Industrial Property Rights Type
      特許
    • Filing Date
      2017
    • Related Report
      2017 Annual Research Report
    • Overseas
  • [Patent(Industrial Property Rights)] カルボキシペプチダーゼ活性検出用蛍光プローブ2017

    • Inventor(s)
      浦野泰照、神谷真子、栗木優五
    • Industrial Property Rights Holder
      国立大学法人 東京大学
    • Industrial Property Rights Type
      特許
    • Industrial Property Number
      2017-040165
    • Filing Date
      2017-03-03
    • Related Report
      2016 Annual Research Report
  • [Patent(Industrial Property Rights)] ペプチダーゼ活性検出用近赤外蛍光プローブ2017

    • Inventor(s)
      浦野泰照、神谷真子、岩立竜
    • Industrial Property Rights Holder
      国立大学法人 東京大学
    • Industrial Property Rights Type
      特許
    • Industrial Property Number
      2017-037459
    • Filing Date
      2017-02-28
    • Related Report
      2016 Annual Research Report
  • [Patent(Industrial Property Rights)] 酵素特異的な細胞内滞留性赤色蛍光プローブ2016

    • Inventor(s)
      浦野泰照、神谷真子、伊藤央樹、川又優
    • Industrial Property Rights Holder
      国立大学法人 東京大学
    • Industrial Property Rights Type
      特許
    • Industrial Property Number
      2016-130024
    • Filing Date
      2016-06-30
    • Related Report
      2016 Annual Research Report

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Published: 2015-07-02   Modified: 2022-11-04  

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