| Budget Amount *help |
¥146,120,000 (Direct Cost: ¥112,400,000、Indirect Cost: ¥33,720,000)
Fiscal Year 2019: ¥27,820,000 (Direct Cost: ¥21,400,000、Indirect Cost: ¥6,420,000)
Fiscal Year 2018: ¥27,820,000 (Direct Cost: ¥21,400,000、Indirect Cost: ¥6,420,000)
Fiscal Year 2017: ¥27,820,000 (Direct Cost: ¥21,400,000、Indirect Cost: ¥6,420,000)
Fiscal Year 2016: ¥27,820,000 (Direct Cost: ¥21,400,000、Indirect Cost: ¥6,420,000)
Fiscal Year 2015: ¥34,840,000 (Direct Cost: ¥26,800,000、Indirect Cost: ¥8,040,000)
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| Outline of Final Research Achievements |
We have developed an innovative bioimaging technology and cancer model medaka for analysis of cancer metastasis mechanism and drug discovery. As an instrument development, we succeeded in developing a new two-photon excitation optical sheet microscope with a uniform wide field of view using a bessel beam illumination. In fact, we succeeded in high-resolution imaging of the whole body of medaka fry and long-term ecological observation. For image analysis, we succeeded in quantitative morphology measurement using texture image information and 3D imaging with improved control software. Furthermore, for deep observation of the living body, we succeeded in improving the mismatch of the refractive index difference at the interface by applying nanosheets. In addition, we were able to analyze the dynamics of cells and the cancer microenvironment of human cancer cells transplanted into immunodeficient medaka.
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