| Co-Investigator(Kenkyū-buntansha) |
佐藤 俊一 東北大学, 多元物質科学研究所, 教授 (30162431)
榎木 亮介 大学共同利用機関法人自然科学研究機構(新分野創成センター、アストロバイオロジーセンター、生命創成探究, 生命創成探究センター, 准教授 (00528341)
大友 康平 大学共同利用機関法人自然科学研究機構(新分野創成センター、アストロバイオロジーセンター、生命創成探究, 生命創成探究センター, 助教 (40547204)
川上 良介 愛媛大学, 大学院医学系研究科, 准教授 (40508818)
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| Budget Amount *help |
¥119,730,000 (Direct Cost: ¥92,100,000、Indirect Cost: ¥27,630,000)
Fiscal Year 2019: ¥18,460,000 (Direct Cost: ¥14,200,000、Indirect Cost: ¥4,260,000)
Fiscal Year 2018: ¥18,590,000 (Direct Cost: ¥14,300,000、Indirect Cost: ¥4,290,000)
Fiscal Year 2017: ¥18,590,000 (Direct Cost: ¥14,300,000、Indirect Cost: ¥4,290,000)
Fiscal Year 2016: ¥18,590,000 (Direct Cost: ¥14,300,000、Indirect Cost: ¥4,290,000)
Fiscal Year 2015: ¥45,500,000 (Direct Cost: ¥35,000,000、Indirect Cost: ¥10,500,000)
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| Outline of Final Research Achievements |
Bioimaging using two-photon excitation fluorescence and second-harmonic generation enables quantitative analysis of the dynamics of many types of molecules and cells within living tissues with high spatiotemporal resolution. In this research project, we promoted the advancement of in vivo two-photon microscopy, which was led by the research group ahead of the world, and opened the way to 3D live imaging. In particular, we introduced a spatial modulation technology for laser beam light to achieve super-resolution and ultra-deep depth. Also, we have realized a methodology for visualizing and analyzing high-speed events in living organisms as they are, and established a new imaging method to understand molecular mechanisms from higher-order information such as molecular orientation. Furthermore, we promoted super-resolution imaging using a new laser beam "vector beam."
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