| Budget Amount *help |
¥76,000,000 (Direct Cost: ¥76,000,000)
Fiscal Year 2009: ¥10,500,000 (Direct Cost: ¥10,500,000)
Fiscal Year 2008: ¥10,500,000 (Direct Cost: ¥10,500,000)
Fiscal Year 2007: ¥14,600,000 (Direct Cost: ¥14,600,000)
Fiscal Year 2006: ¥15,100,000 (Direct Cost: ¥15,100,000)
Fiscal Year 2005: ¥17,000,000 (Direct Cost: ¥17,000,000)
Fiscal Year 2004: ¥8,300,000 (Direct Cost: ¥8,300,000)
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| Research Abstract |
A marine invertebrate, Oligobrachia mashikoi, has a novel extracellular giant hemoglobin which transports oxygen and sulfide simultaneously. In the present study, we determined the crystal structures of a 400-kDa Hb oxy from and deoxy form by X-ray crystallographic analyses and proposed the new mechanism on oxygen cooperativity which is quite different from those of the well-studied mammalian Hbs.
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